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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:camptothecin
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Accession:CHEBI:27656 term browser browse the term
Definition:A pyranoindolizinoquinoline that is pyrano[3',4':6,7]indolizino[1,2-b]quinoline which is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the S enantiomer).
Synonyms:exact_synonym: (4S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
 related_synonym: (S)-(+)-camptothecin;   20(S)-camptothecine;   21,22-Secocamptothecin-21-oic acid lactone;   CPT;   Camptothecine;   D-camptothecin;   Formula=C20H16N2O4;   InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1;   InChIKey=VSJKWCGYPAHWDS-FQEVSTJZSA-N;   SMILES=CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccccc4cc3Cn1c2=O
 alt_id: CHEBI:22997;   CHEBI:3343
 xref: Beilstein:6075662;   CAS:7689-03-4;   DrugBank:DB04690;   KEGG:C01897;   KNApSAcK:C00002145;   LINCS:LSM-4611
 xref_mesh: MESH:D002166
 xref: PDBeChem:EHD;   PMID:11024478;   PMID:11549373;   PMID:23344961;   PMID:23474217;   PMID:23676007;   PMID:8965250;   Reaxys:6075662;   Wikipedia:Camptothecin


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camptothecin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A decreases expression
multiple interactions		 ISO Camptothecin results in decreased expression of ABCB1 mRNA; Camptothecin results in decreased expression of ABCB1 protein
Camptothecin inhibits the reaction [Rifampin results in increased expression of ABCB1 mRNA]		 CTD PMID:10692111 PMID:29356861 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcc1 ATP-binding cassette, sub-family C member 1 decreases response to substance
multiple interactions		 ISO ABCC1 protein results in decreased susceptibility to Camptothecin analog
Camptothecin inhibits the reaction [ABCC1 results in decreased susceptibility to Daunorubicin]		 CTD PMID:11778547 PMID:12115804 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601 		JBrowse link
G Acvr1b activin A receptor, type 1B increases methylation ISO Camptothecin results in increased methylation of ACVR1B gene CTD PMID:30720231 NCBI chr15:101,071,953...101,111,565
Ensembl chr15:101,071,948...101,111,565 		JBrowse link
G Adam19 ADAM metallopeptidase domain 19 decreases response to substance ISO ADAM19 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr11:45,945,329...46,038,174
Ensembl chr11:45,946,819...46,038,170 		JBrowse link
G Agap1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 increases methylation ISO Camptothecin results in increased methylation of AGAP1 gene CTD PMID:30720231 NCBI chr 1:89,382,533...89,823,004
Ensembl chr 1:89,382,528...89,825,339 		JBrowse link
G Agrn agrin increases expression ISO Camptothecin results in increased expression of AGRN mRNA CTD PMID:17374387 NCBI chr 4:156,249,747...156,281,997
Ensembl chr 4:156,249,747...156,281,945 		JBrowse link
G Agrp agouti related neuropeptide decreases response to substance ISO AGRP mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 8:106,293,327...106,306,477
Ensembl chr 8:106,293,330...106,364,025 		JBrowse link
G Aifm3 apoptosis-inducing factor, mitochondrion-associated 3 decreases response to substance ISO AIFM3 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr16:17,307,418...17,325,349
Ensembl chr16:17,307,475...17,325,349 		JBrowse link
G Akap13 A kinase anchor protein 13 decreases response to substance ISO AKAP13 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 7:75,105,271...75,404,357
Ensembl chr 7:75,105,282...75,404,357 		JBrowse link
G Akap8 A kinase anchor protein 8 increases expression ISO Camptothecin results in increased expression of AKAP8 mRNA CTD PMID:33770205 NCBI chr17:32,522,646...32,540,212
Ensembl chr17:32,522,646...32,540,212 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 affects phosphorylation
multiple interactions
increases phosphorylation		 ISO Camptothecin affects the phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Camptothecin results in increased phosphorylation of AKT1 protein]; Camptothecin results in decreased expression of and results in decreased phosphorylation of AKT1 protein; Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in decreased phosphorylation of AKT1 protein]; Nicotine affects the reaction [Camptothecin affects the phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Camptothecin results in increased phosphorylation of AKT1 protein]		 CTD PMID:24095863 PMID:30851366 PMID:36394428 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Alb albumin affects binding
multiple interactions		 ISO Camptothecin analog binds to ALB protein; Camptothecin binds to ALB protein
CTSB protein results in increased cleavage of [Camptothecin analog binds to ALB protein]		 CTD PMID:10803926 PMID:17378599 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Alms1 ALMS1, centrosome and basal body associated decreases methylation ISO Camptothecin results in decreased methylation of ALMS1 gene CTD PMID:30720231 NCBI chr 6:85,564,482...85,698,973
Ensembl chr 6:85,564,513...85,679,735 		JBrowse link
G Anxa4 annexin A4 increases expression ISO Camptothecin results in increased expression of ANXA4 mRNA CTD PMID:17374387 NCBI chr 6:86,713,822...86,770,616
Ensembl chr 6:86,713,822...86,770,566 		JBrowse link
G Apc APC, WNT signaling pathway regulator increases methylation ISO Camptothecin results in increased methylation of APC gene CTD PMID:30720231 NCBI chr18:34,353,350...34,455,243
Ensembl chr18:34,353,977...34,455,605 		JBrowse link
G Ar androgen receptor multiple interactions ISO Camptothecin binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821 		JBrowse link
G Artn artemin decreases response to substance ISO ARTN mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 4:117,783,105...117,787,993
Ensembl chr 4:117,783,359...117,786,960 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression		 ISO Glutathione inhibits the reaction [Camptothecin results in increased expression of ATF4 protein]; MYC protein affects the reaction [Camptothecin results in increased expression of ATF4 protein] CTD PMID:30266318 NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742 		JBrowse link
G Atg5 autophagy related 5 multiple interactions ISO ATG5 mutant form inhibits the reaction [Camptothecin results in increased degradation of SQSTM1 protein] CTD PMID:22927544 NCBI chr10:44,144,325...44,240,295
Ensembl chr10:44,144,354...44,240,287 		JBrowse link
G Atg7 autophagy related 7 multiple interactions
increases expression		 ISO Egtazic Acid inhibits the reaction [Camptothecin results in increased expression of ATG7 protein]; EIF2S1 protein affects the reaction [Camptothecin results in increased expression of ATG7 protein]; staurosporine aglycone inhibits the reaction [Camptothecin results in increased expression of ATG7 protein] CTD PMID:30266318 NCBI chr 6:114,620,075...114,837,565
Ensembl chr 6:114,620,058...114,837,575 		JBrowse link
G Atm ataxia telangiectasia mutated decreases expression
increases expression
multiple interactions
increases activity		 ISO Camptothecin results in decreased expression of ATM mRNA
Camptothecin results in increased expression of ATM protein modified form
Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of ATM protein modified form]; ESR1 promotes the reaction [Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of ATM protein modified form]]
camptothecin increases kinase activity in rat cerebellar granule neurons		 CTD
RGD		 PMID:24792648 PMID:30720231 PMID:19151707 RGD:10053571 NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040 		JBrowse link
G Atr ataxia telangiectasia and Rad3 related decreases response to substance
multiple interactions
increases phosphorylation		 ISO ATR mRNA results in decreased susceptibility to Camptothecin; ATR protein results in decreased susceptibility to Camptothecin
3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [Camptothecin results in increased phosphorylation of ATR protein]		 CTD PMID:25269479 PMID:30555576 NCBI chr 9:95,739,655...95,834,813
Ensembl chr 9:95,739,650...95,833,834 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 decreases expression
multiple interactions		 ISO Camptothecin results in decreased expression of BAK1 mRNA
Folic Acid inhibits the reaction [Camptothecin results in decreased expression of BAK1 mRNA]		 CTD PMID:30581319 NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983 		JBrowse link
G Bax BCL2-associated X protein multiple interactions
increases activity
increases expression
decreases expression		 ISO [Camptothecin co-treated with 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole] results in decreased expression of BAX protein; Camptothecin affects the cleavage of and results in decreased expression of BAX protein; Folic Acid inhibits the reaction [Camptothecin results in decreased expression of BAX mRNA]
Camptothecin results in increased activity of BAX protein
Camptothecin results in increased expression of BAX protein
pifithrin inhibits the reaction [Camptothecin results in increased expression of BAX protein]
Camptothecin results in decreased expression of BAX mRNA; Camptothecin results in decreased expression of BAX protein		 CTD PMID:11279278 PMID:15665116 PMID:17555331 PMID:19481069 PMID:30581319 More... NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bbc3 BCL2 binding component 3 affects response to substance EXP BBC3 protein affects the susceptibility to Camptothecin CTD PMID:20477944 NCBI chr 7:16,042,307...16,052,130
Ensembl chr 7:16,042,318...16,052,130 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases response to substance
decreases expression
increases expression		 ISO
EXP		 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole promotes the reaction [Camptothecin results in decreased expression of BCL2 protein]; Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in decreased expression of BCL2 protein]; Folic Acid inhibits the reaction [Camptothecin results in decreased expression of BCL2 mRNA]
BCL2 results in decreased susceptibility to Camptothecin
Camptothecin results in decreased expression of BCL2 mRNA; Camptothecin results in decreased expression of BCL2 protein
Camptothecin results in increased expression of BCL2 mRNA
Camptothecin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of BCL2 protein]		 CTD PMID:9664115 PMID:10692111 PMID:10896673 PMID:19481069 PMID:24726431 More... NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l1 BCL2-like 1 decreases response to substance
decreases expression
increases expression
multiple interactions		 ISO BCL2L1 gene mutant form results in decreased susceptibility to Camptothecin
Camptothecin results in decreased expression of BCL2L1 protein alternative form
Camptothecin results in increased expression of BCL2L1 protein
Dexamethasone inhibits the reaction [Camptothecin results in decreased expression of BCL2L1 protein alternative form]; Mifepristone affects the reaction [Dexamethasone inhibits the reaction [Camptothecin results in decreased expression of BCL2L1 protein alternative form]]; Naphthoquinones analog promotes the reaction [Camptothecin results in increased expression of BCL2L1 protein]
BCL2L1 mRNA results in decreased susceptibility to Camptothecin
Folic Acid inhibits the reaction [Camptothecin results in decreased expression of BCL2L1 mRNA]		 CTD PMID:10970895 PMID:19339209 PMID:19497415 PMID:25269479 PMID:30581319 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Becn1 beclin 1, autophagy related increases expression
multiple interactions		 ISO Camptothecin results in increased expression of BECN1 protein
[Diethylhexyl Phthalate co-treated with Camptothecin] results in decreased expression of BECN1 protein; Egtazic Acid inhibits the reaction [Camptothecin results in increased expression of BECN1 protein]; EIF2S1 protein affects the reaction [Camptothecin results in increased expression of BECN1 protein]; staurosporine aglycone inhibits the reaction [Camptothecin results in increased expression of BECN1 protein]		 CTD PMID:30266318 PMID:36394428 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [Camptothecin co-treated with 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole] results in increased cleavage of and results in decreased expression of BID protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of BID protein; Camptothecin results in increased cleavage of and results in decreased expression of BID protein CTD PMID:19481069 PMID:19633536 NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
increases expression
decreases expression		 ISO
EXP		 [Butyrates co-treated with Camptothecin] results in decreased expression of BIRC5 protein; [Folic Acid co-treated with Camptothecin] results in decreased expression of BIRC5 mRNA
Camptothecin results in increased expression of BIRC5 mRNA
Camptothecin results in decreased expression of BIRC5 mRNA
Camptothecin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of BIRC5 protein]		 CTD PMID:16061681 PMID:24726431 PMID:25449198 PMID:30581319 NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569 		JBrowse link
G Bnip1 BCL2/adenovirus E1B interacting protein 1 increases expression ISO Camptothecin results in increased expression of BNIP1 mRNA CTD PMID:33770205 NCBI chr17:26,999,876...27,011,539
Ensembl chr17:27,000,040...27,011,539 		JBrowse link
G Brca1 breast cancer 1, early onset decreases expression
decreases response to substance		 ISO Camptothecin results in decreased expression of BRCA1 mRNA
BRCA1 mRNA results in decreased susceptibility to Camptothecin		 CTD PMID:10344722 PMID:25269479 NCBI chr11:101,379,587...101,442,808
Ensembl chr11:101,379,590...101,442,781 		JBrowse link
G Brca2 breast cancer 2, early onset decreases expression ISO Camptothecin results in decreased expression of BRCA2 mRNA CTD PMID:10344722 NCBI chr 5:150,445,759...150,493,612
Ensembl chr 5:150,446,095...150,493,794 		JBrowse link
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin increases expression EXP Camptothecin results in increased expression of BSCL2 mRNA CTD PMID:22003191 NCBI chr19:8,814,831...8,826,047
Ensembl chr19:8,814,831...8,826,047 		JBrowse link
G Cab39 calcium binding protein 39 decreases expression ISO Camptothecin results in decreased expression of CAB39 mRNA CTD PMID:17374387 NCBI chr 1:85,707,796...85,779,298
Ensembl chr 1:85,721,162...85,779,297 		JBrowse link
G Casp2 caspase 2 increases splicing
increases expression		 ISO Camptothecin results in increased splicing of CASP2 mRNA
Camptothecin results in increased expression of CASP2 mRNA alternative form		 CTD PMID:14757846 NCBI chr 6:42,241,942...42,259,442
Ensembl chr 6:42,241,919...42,259,442 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage		 ISO
EXP		 15-deoxyprostaglandin J2 promotes the reaction [Camptothecin results in increased activity of CASP3 protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole promotes the reaction [Camptothecin results in increased activity of CASP3 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Camptothecin results in increased activity of CASP3 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [Camptothecin results in increased activity of CASP3 protein]; [Camptothecin co-treated with FAS protein] results in increased activity of CASP3 protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of CASP3 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Camptothecin results in increased cleavage of CASP3 protein]; Camptothecin promotes the reaction [15-deoxyprostaglandin J2 results in increased activity of CASP3 protein]; Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased cleavage of CASP3 protein]; palbociclib inhibits the reaction [Camptothecin results in increased activity of CASP3 protein]; SMN1 mRNA affects the reaction [Camptothecin results in increased activity of CASP3 protein]; THBS1 protein inhibits the reaction [Camptothecin results in increased activity of CASP3 protein]
Cadmium Chloride inhibits the reaction [Camptothecin results in increased cleavage of CASP3 protein]; Cadmium inhibits the reaction [Camptothecin results in increased cleavage of CASP3 protein]; Dexamethasone inhibits the reaction [Camptothecin results in increased activity of CASP3 protein]; Naphthoquinones analog inhibits the reaction [Camptothecin results in increased activity of CASP3 protein]; Tetrachlorodibenzodioxin promotes the reaction [Camptothecin results in increased cleavage of CASP3 protein]		 CTD PMID:10896673 PMID:15862279 PMID:15958570 PMID:16263807 PMID:16273314 More... NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
decreases expression		 ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Camptothecin results in increased activity of CASP7 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [Camptothecin results in increased activity of CASP7 protein]; palbociclib inhibits the reaction [Camptothecin results in increased activity of CASP7 protein]
Camptothecin results in decreased expression of CASP7 mRNA		 CTD PMID:22302033 PMID:24726431 PMID:30581319 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776 		JBrowse link
G Casp8 caspase 8 multiple interactions
affects cleavage
increases activity
increases expression
decreases expression		 ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Camptothecin results in increased activity of CASP8 protein]; [Camptothecin co-treated with FAS protein] results in increased activity of CASP8 protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of CASP8 protein; Lithium inhibits the reaction [Camptothecin results in increased activity of CASP8 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of CASP8 protein]
Camptothecin affects the cleavage of CASP8 protein
Naphthoquinones analog inhibits the reaction [Camptothecin results in increased activity of CASP8 protein]
Camptothecin results in decreased expression of CASP8 mRNA		 CTD PMID:10896673 PMID:15475000 PMID:15958570 PMID:19497415 PMID:19633536 More... NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
increases cleavage
increases expression
decreases expression		 ISO [Camptothecin co-treated with FAS protein] results in increased activity of CASP9 protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of CASP9 protein; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of CASP9 protein]
benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Camptothecin results in increased cleavage of CASP9 protein]; Cadmium Chloride inhibits the reaction [Camptothecin results in increased activity of CASP9 protein]; Cadmium inhibits the reaction [Camptothecin results in increased activity of CASP9 protein]; Naphthoquinones analog inhibits the reaction [Camptothecin results in increased activity of CASP9 protein]
Camptothecin results in decreased expression of CASP9 mRNA		 CTD PMID:10896673 PMID:15958570 PMID:16263807 PMID:19497415 PMID:19633536 More... NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cav1 caveolin 1, caveolae protein decreases methylation ISO Camptothecin results in decreased methylation of CAV1 gene CTD PMID:30720231 NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Camptothecin results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Camptothecin results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr11:83,553,410...83,555,509
Ensembl chr11:83,553,410...83,555,509 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Camptothecin results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344 		JBrowse link
G Ccna2 cyclin A2 multiple interactions
decreases expression		 ISO [Folic Acid co-treated with Camptothecin] results in decreased expression of CCNA2 mRNA
Camptothecin results in decreased expression of CCNA2 mRNA		 CTD PMID:30581319 NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions
increases expression
decreases expression		 ISO [Butyrates co-treated with Camptothecin] results in decreased expression of CCNB1 protein; CDKN1A protein affects the reaction [Camptothecin results in increased expression of CCNB1 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of CCNB1 protein]; MAPK8 protein affects the reaction [Camptothecin results in increased expression of CCNB1 protein]
Camptothecin results in decreased expression of CCNB1 protein		 CTD PMID:16061681 PMID:23376119 PMID:30851366 PMID:30885713 PMID:31255635 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078 		JBrowse link
G Ccnd1 cyclin D1 affects localization EXP Camptothecin affects the localization of CCND1 protein CTD PMID:14647467 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Ccne1 cyclin E1 increases expression ISO Camptothecin results in increased expression of CCNE1 protein CTD PMID:30851366 NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959 		JBrowse link
G Cdc20 cell division cycle 20 multiple interactions ISO Camptothecin promotes the reaction [MAD2L1 protein binds to CDC20 protein] CTD PMID:30885713 NCBI chr 4:118,290,098...118,294,540
Ensembl chr 4:118,290,098...118,294,549 		JBrowse link
G Cdk1 cyclin dependent kinase 1 multiple interactions ISO Camptothecin results in increased expression of and results in increased activity of CDK1 protein; CDKN1A protein affects the reaction [Camptothecin results in increased activity of CDK1 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of and results in increased activity of CDK1 protein]; MAPK8 protein affects the reaction [Camptothecin results in increased expression of CDK1 protein] CTD PMID:30885713 NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions
increases activity		 ISO Camptothecin results in increased phosphorylation of and results in decreased activity of CDK2 protein
camptothecin increases kinase activity in rat cerebellar granule neurons		 CTD
RGD		 PMID:15141020 PMID:19151707 RGD:10053571 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900 		JBrowse link
G Cdk5 cyclin dependent kinase 5 increases activity ISO camptothecin increases kinase activity in rat cerebellar granule neurons RGD PMID:19151707 RGD:10053571 NCBI chr 5:24,612,595...24,628,737
Ensembl chr 5:24,623,239...24,628,528 		JBrowse link
G Cdk5r1 cyclin dependent kinase 5, regulatory subunit 1 increases expression ISO Camptothecin results in increased expression of CDK5R1 mRNA CTD PMID:33770205 NCBI chr11:80,367,849...80,372,010
Ensembl chr11:80,367,849...80,372,010 		JBrowse link
G Cdk6 cyclin dependent kinase 6 increases activity ISO camptothecin increases kinase activity in rat cerebellar granule neurons RGD PMID:19151707 RGD:10053571 NCBI chr 5:3,391,004...3,581,008
Ensembl chr 5:3,391,485...3,581,008 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression
multiple interactions		 ISO Camptothecin results in increased expression of CDKN1A mRNA; Camptothecin results in increased expression of CDKN1A protein
Aspirin inhibits the reaction [Camptothecin results in increased expression of CDKN1A protein]; Camptothecin results in increased expression of and results in increased phosphorylation of CDKN1A protein; CDKN1A protein affects the reaction [Camptothecin results in increased activity of CDK1 protein]; CDKN1A protein affects the reaction [Camptothecin results in increased expression of CCNB1 protein]; CDKN1A protein affects the reaction [Camptothecin results in increased expression of MAD2L1 protein]		 CTD PMID:9673414 PMID:17555331 PMID:19212664 PMID:24211769 PMID:30022047 More... NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 increases expression ISO Camptothecin results in increased expression of CEACAM1 mRNA CTD PMID:17374387 NCBI chr 7:25,161,127...25,177,072
Ensembl chr 7:25,161,132...25,177,028 		JBrowse link
G Cebpz CCAAT/enhancer binding protein zeta decreases expression ISO Camptothecin results in decreased expression of CEBPZ mRNA CTD PMID:17374387 NCBI chr17:79,226,432...79,244,499
Ensembl chr17:79,226,435...79,244,495 		JBrowse link
G Cep85l centrosomal protein 85-like increases methylation ISO Camptothecin results in increased methylation of CEP85L gene CTD PMID:30720231 NCBI chr10:53,149,537...53,256,765
Ensembl chr10:53,149,539...53,256,043 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions EXP Camptothecin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of CFLAR protein] CTD PMID:25449198 NCBI chr 1:58,750,353...58,798,043
Ensembl chr 1:58,750,667...58,798,043 		JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions
increases phosphorylation
increases expression
decreases response to substance		 EXP
ISO		 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein]; 7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased expression of CHEK1 mRNA]; 7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein]; Caffeine inhibits the reaction [Camptothecin results in increased expression of CHEK1 mRNA]; Caffeine inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein]
3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [Camptothecin results in increased expression of CHEK1 protein modified form]; Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of CHEK1 protein modified form]
CHEK1 mRNA results in decreased susceptibility to Camptothecin		 CTD PMID:21646468 PMID:22403396 PMID:25269479 PMID:30555576 PMID:30720231 NCBI chr 9:36,619,935...36,637,897
Ensembl chr 9:36,619,778...36,638,361 		JBrowse link
G Chek2 checkpoint kinase 2 increases expression
increases phosphorylation
multiple interactions		 ISO Camptothecin results in increased expression of CHEK2 protein modified form
Camptothecin results in increased phosphorylation of CHEK2 protein
Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of CHEK2 protein modified form]		 CTD PMID:21646468 PMID:25269479 PMID:25977998 PMID:30720231 NCBI chr 5:110,987,668...111,022,006
Ensembl chr 5:110,987,845...111,022,011 		JBrowse link
G Clptm1l CLPTM1-like increases response to substance ISO CLPTM1L mutant form results in increased susceptibility to Camptothecin CTD PMID:22675468 NCBI chr13:73,752,121...73,768,758
Ensembl chr13:73,752,125...73,768,724 		JBrowse link
G Coil coilin increases expression ISO Camptothecin results in increased expression of COIL mRNA CTD PMID:33770205 NCBI chr11:88,864,761...88,882,439
Ensembl chr11:88,861,078...88,882,439 		JBrowse link
G Crebbp CREB binding protein multiple interactions ISO Camptothecin inhibits the reaction [RELA protein binds to CREBBP protein]; Camptothecin promotes the reaction [TP53 protein binds to CREBBP protein]; pifithrin inhibits the reaction [Camptothecin inhibits the reaction [RELA protein binds to CREBBP protein]]; pifithrin inhibits the reaction [Camptothecin promotes the reaction [TP53 protein binds to CREBBP protein]] CTD PMID:13679428 NCBI chr16:3,899,198...4,031,864
Ensembl chr16:3,899,192...4,031,861 		JBrowse link
G Crx cone-rod homeobox decreases response to substance ISO CRX mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 7:15,599,872...15,613,880
Ensembl chr 7:15,599,872...15,613,893 		JBrowse link
G Ctsb cathepsin B multiple interactions ISO CTSB protein results in increased cleavage of [Camptothecin analog binds to ALB protein] CTD PMID:17378599 NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 decreases expression
increases secretion
multiple interactions
decreases response to substance		 ISO Camptothecin results in decreased expression of CXCL8 protein
Camptothecin results in increased secretion of CXCL8 protein
Ciprofloxacin inhibits the reaction [Camptothecin results in increased secretion of CXCL8 protein]; moxifloxacin inhibits the reaction [Camptothecin results in increased secretion of CXCL8 protein]
CXCL8 protein results in decreased susceptibility to Camptothecin		 CTD PMID:16356833 PMID:18191106 PMID:20116850 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions
affects localization		 ISO 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole promotes the reaction [Camptothecin affects the localization of CYCS protein] CTD PMID:19481069 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 decreases response to substance ISO CYP26B1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 6:84,548,396...84,570,890
Ensembl chr 6:84,548,396...84,570,890 		JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 decreases expression
multiple interactions		 ISO Camptothecin results in decreased expression of CYP2B6 mRNA
Camptothecin inhibits the reaction [Rifampin results in increased expression of CYP2B6 mRNA]		 CTD PMID:29356861 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049 		JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 multiple interactions
decreases expression		 ISO Camptothecin inhibits the reaction [Rifampin results in increased expression of CYP2C8 mRNA]
Camptothecin results in decreased expression of CYP2C8 mRNA		 CTD PMID:29356861 NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
decreases expression		 ISO Camptothecin results in increased expression of DDIT3 protein
Folic Acid inhibits the reaction [Camptothecin results in decreased expression of DDIT3 mRNA]; MYC protein affects the reaction [Camptothecin results in increased expression of DDIT3 protein]		 CTD PMID:30266318 PMID:30581319 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Dgkz diacylglycerol kinase zeta decreases response to substance ISO DGKZ mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 2:91,763,167...91,806,788
Ensembl chr 2:91,763,169...91,806,209 		JBrowse link
G Dpyd dihydropyrimidine dehydrogenase multiple interactions
decreases expression
decreases activity		 ISO Camptothecin inhibits the reaction [Fluorouracil results in increased expression of DPYD mRNA]
Camptothecin results in decreased expression of DPYD mRNA
Camptothecin results in decreased activity of DPYD protein		 CTD PMID:16568373 NCBI chr 3:118,355,758...119,226,573
Ensembl chr 3:118,355,778...119,226,573 		JBrowse link
G Dtwd1 DTW domain containing 1 increases expression ISO Camptothecin results in increased expression of DTWD1 mRNA CTD PMID:33770205 NCBI chr 2:125,993,981...126,007,197
Ensembl chr 2:125,994,061...126,007,199 		JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions
increases expression		 EXP 7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased expression of E2F1 mRNA]; Caffeine inhibits the reaction [Camptothecin results in increased expression of E2F1 mRNA]; E2F1 protein promotes the reaction [Camptothecin results in increased expression of RRM2 protein] CTD PMID:22403396 NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812 		JBrowse link
G E2f8 E2F transcription factor 8 increases expression ISO Camptothecin results in increased expression of E2F8 mRNA CTD PMID:33770205 NCBI chr 7:48,516,177...48,531,821
Ensembl chr 7:48,516,177...48,531,344 		JBrowse link
G Ei24 etoposide induced 2.4 mRNA increases expression ISO Camptothecin results in increased expression of EI24 mRNA CTD PMID:17374387 NCBI chr 9:36,690,449...36,708,630
Ensembl chr 9:36,690,455...36,708,689 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation
multiple interactions		 ISO Camptothecin results in increased phosphorylation of EIF2AK3 protein
Glutathione inhibits the reaction [Camptothecin results in increased phosphorylation of EIF2AK3 protein]; MYC protein affects the reaction [Camptothecin results in increased phosphorylation of EIF2AK3 protein]		 CTD PMID:30266318 NCBI chr 6:70,821,468...70,882,225
Ensembl chr 6:70,821,499...70,882,229 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha increases phosphorylation
multiple interactions		 ISO Camptothecin results in increased phosphorylation of EIF2S1 protein
EIF2S1 protein affects the reaction [Camptothecin results in increased expression of ATG7 protein]; EIF2S1 protein affects the reaction [Camptothecin results in increased expression of BECN1 protein]; Glutathione inhibits the reaction [Camptothecin results in increased phosphorylation of EIF2S1 protein]; MYC protein affects the reaction [Camptothecin results in increased phosphorylation of EIF2S1 protein]
[Camptothecin co-treated with GW 506033X] results in increased phosphorylation of EIF2S1 protein		 CTD PMID:19046382 PMID:30266318 NCBI chr12:78,908,846...78,933,784
Ensembl chr12:78,908,593...78,933,784 		JBrowse link
G Ep300 E1A binding protein p300 decreases expression ISO Camptothecin results in decreased expression of EP300 mRNA; Camptothecin results in decreased expression of EP300 protein CTD PMID:10344722 NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278 		JBrowse link
G Epm2aip1 EPM2A interacting protein 1 increases expression ISO Camptothecin results in increased expression of EPM2AIP1 mRNA CTD PMID:17374387 NCBI chr 9:111,100,913...111,108,161
Ensembl chr 9:111,100,997...111,108,161 		JBrowse link
G Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 multiple interactions
decreases expression		 ISO ERCC1 protein promotes the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]]
Camptothecin results in decreased expression of ERCC1 mRNA		 CTD PMID:21227924 PMID:24792648 NCBI chr 7:19,079,016...19,090,449
Ensembl chr 7:19,078,703...19,090,449 		JBrowse link
G Ercc4 excision repair cross-complementing rodent repair deficiency, complementation group 4 multiple interactions
decreases response to substance		 ISO ERCC4 protein promotes the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]]
ERCC4 protein results in decreased susceptibility to Camptothecin		 CTD PMID:21227924 NCBI chr16:12,927,600...12,969,873
Ensembl chr16:12,927,548...12,968,481 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO Camptothecin binds to and results in decreased activity of ESR1 protein; ESR1 promotes the reaction [Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of ATM protein modified form]]; ESR1 promotes the reaction [Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form]] CTD PMID:25752796 PMID:30720231 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Esr2 estrogen receptor 2 (beta) multiple interactions ISO Camptothecin binds to and results in decreased activity of ESR2 protein CTD PMID:25752796 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Camptothecin results in increased expression of and affects the localization of FAS protein]; [Camptothecin co-treated with FAS protein] results in decreased expression of XIAP protein; [Camptothecin co-treated with FAS protein] results in increased activity of CASP3 protein; [Camptothecin co-treated with FAS protein] results in increased activity of CASP8 protein; [Camptothecin co-treated with FAS protein] results in increased activity of CASP9 protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of BID protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of CASP3 protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of CASP8 protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of CASP9 protein; Camptothecin results in increased expression of and affects the localization of FAS protein; Lithium inhibits the reaction [Camptothecin results in increased expression of and affects the localization of FAS protein] CTD PMID:15475000 PMID:15958570 PMID:19633536 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fdxr ferredoxin reductase increases expression ISO Camptothecin results in increased expression of FDXR mRNA CTD PMID:17374387 NCBI chr11:115,158,850...115,167,925
Ensembl chr11:115,158,850...115,167,876 		JBrowse link
G Fxn frataxin increases expression ISO Camptothecin results in increased expression of FXN protein CTD PMID:23418481 NCBI chr19:24,236,909...24,257,954
Ensembl chr19:24,238,817...24,257,969 		JBrowse link
G Fzd1 frizzled class receptor 1 decreases methylation ISO Camptothecin results in decreased methylation of FZD1 gene CTD PMID:30720231 NCBI chr 5:4,803,839...4,808,216
Ensembl chr 5:4,803,839...4,808,035 		JBrowse link
G Fzd8 frizzled class receptor 8 decreases methylation ISO Camptothecin results in decreased methylation of FZD8 gene CTD PMID:30720231 NCBI chr18:9,212,856...9,216,201
Ensembl chr18:9,212,163...9,218,136 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha decreases expression
multiple interactions		 ISO Camptothecin results in decreased expression of GADD45A mRNA
Folic Acid inhibits the reaction [Camptothecin results in decreased expression of GADD45A mRNA]		 CTD PMID:24792648 PMID:30581319 NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441 		JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible 45 gamma increases expression ISO Camptothecin results in increased expression of GADD45G mRNA CTD PMID:24792648 NCBI chr13:52,000,711...52,002,511
Ensembl chr13:52,000,714...52,002,504 		JBrowse link
G Git2 GIT ArfGAP 2 decreases response to substance ISO GIT2 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 5:114,865,469...114,912,647
Ensembl chr 5:114,865,468...114,913,578 		JBrowse link
G Gm20348 predicted gene, 20348 increases expression ISO Camptothecin results in increased expression of TP53I3 mRNA CTD PMID:17374387 NCBI chr12:4,860,475...4,867,155
Ensembl chr12:4,860,494...4,867,142 		JBrowse link
G Gpx4 glutathione peroxidase 4 decreases response to substance ISO GPX4 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 increases expression
decreases response to substance		 ISO Camptothecin results in increased expression of GSTP1 protein
GSTP1 protein polymorphism results in decreased susceptibility to Camptothecin; GSTP1 protein results in decreased susceptibility to Camptothecin		 CTD PMID:14732228 PMID:15500952 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases expression
increases phosphorylation		 ISO
EXP		 3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form]; [Aminacrine results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]; [MIR138-1 results in decreased expression of H2AX] which results in increased susceptibility to Camptothecin; [Propyl Gallate results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]]; Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form]; ERCC1 protein promotes the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]]; ERCC4 protein promotes the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]]; ESR1 promotes the reaction [Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form]]; H2AX gene mutant form inhibits the reaction [MIR138-1 results in increased susceptibility to Camptothecin]; palbociclib inhibits the reaction [Camptothecin results in increased expression of H2AX protein]; PPP2R2A protein inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form]; PPP2R5C protein promotes the reaction [Camptothecin results in increased expression of H2AX protein modified form]; PPP2R5E protein inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form]; TDP1 protein inhibits the reaction [Camptothecin results in increased expression of H2AX protein]; TDP1 protein inhibits the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]]; veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]
Camptothecin results in increased expression of H2AX protein; Camptothecin results in increased expression of H2AX protein modified form
Camptothecin results in increased phosphorylation of H2AX protein		 CTD PMID:17875725 PMID:21227924 PMID:21646468 PMID:21693595 PMID:22302033 More... NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374 		JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression ISO Camptothecin results in decreased expression of HAMP mRNA CTD PMID:25633564 NCBI chr 7:30,641,793...30,643,454
Ensembl chr 7:30,641,793...30,643,457 		JBrowse link
G Hemk1 HemK methyltransferase family member 1 decreases response to substance ISO HEMK1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 9:107,204,281...107,217,640
Ensembl chr 9:107,204,283...107,215,549 		JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C multiple interactions ISO [HNRNPC protein binds to HNRNPC protein alternative form] which results in decreased susceptibility to Camptothecin CTD PMID:16960656 NCBI chr14:52,310,834...52,341,462
Ensembl chr14:52,310,834...52,341,485 		JBrowse link
G Hoxa1 homeobox A1 decreases response to substance
multiple interactions		 ISO
EXP		 HOXA1 mRNA results in decreased susceptibility to Camptothecin
Camptothecin inhibits the reaction [Vitamin A results in increased expression of HOXA1]		 CTD PMID:25269479 PMID:26820057 NCBI chr 6:52,132,573...52,135,299
Ensembl chr 6:52,132,570...52,135,297 		JBrowse link
G Ibsp integrin binding sialoprotein decreases response to substance ISO IBSP mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 5:104,447,153...104,459,338
Ensembl chr 5:104,447,037...104,459,335 		JBrowse link
G Il1b interleukin 1 beta decreases response to substance ISO IL1B protein results in decreased susceptibility to Camptothecin CTD PMID:16356833 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6ra interleukin 6 receptor, alpha decreases expression ISO Camptothecin results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 3:89,776,631...89,820,503
Ensembl chr 3:89,771,366...89,820,503 		JBrowse link
G Jarid2 jumonji and AT-rich interaction domain containing 2 decreases expression ISO Camptothecin results in decreased expression of JARID2 mRNA CTD PMID:33770205 NCBI chr13:44,881,817...45,075,119
Ensembl chr13:44,882,950...45,075,119 		JBrowse link
G Jun jun proto-oncogene increases expression
increases phosphorylation
multiple interactions		 ISO Camptothecin results in increased expression of JUN protein
Camptothecin results in increased phosphorylation of JUN protein
Glutathione inhibits the reaction [Camptothecin results in increased phosphorylation of JUN protein]; MAPK8 protein affects the reaction [Camptothecin results in increased phosphorylation of JUN protein]		 CTD PMID:9751194 PMID:15585644 PMID:30266318 PMID:30885713 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Kcnk2 potassium channel, subfamily K, member 2 decreases response to substance ISO KCNK2 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 1:188,940,127...189,134,951
Ensembl chr 1:188,940,127...189,134,470 		JBrowse link
G Klhl42 kelch-like 42 increases expression ISO Camptothecin results in increased expression of KLHL42 mRNA CTD PMID:33770205 NCBI chr 6:146,990,783...147,014,276
Ensembl chr 6:146,992,877...147,014,276 		JBrowse link
G Lgals1 lectin, galactose binding, soluble 1 decreases expression ISO Camptothecin results in decreased expression of LGALS1 mRNA; Camptothecin results in decreased expression of LGALS1 protein CTD PMID:19483324 NCBI chr15:78,810,925...78,814,665
Ensembl chr15:78,810,925...78,814,665 		JBrowse link
G Lrch4 leucine-rich repeats and calponin homology (CH) domain containing 4 decreases response to substance ISO LRCH4 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 5:137,627,385...137,639,361
Ensembl chr 5:137,627,383...137,639,361 		JBrowse link
G Mad2l1 MAD2 mitotic arrest deficient-like 1 multiple interactions
increases expression		 ISO Camptothecin promotes the reaction [MAD2L1 protein binds to CDC20 protein]; CDKN1A protein affects the reaction [Camptothecin results in increased expression of MAD2L1 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of and results in increased activity of CDK1 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of CASP8 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of CASP9 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of CCNB1 protein]; MAPK8 protein affects the reaction [Camptothecin results in increased expression of MAD2L1 protein]
Camptothecin results in increased expression of MAD2L1 mRNA; Camptothecin results in increased expression of MAD2L1 protein		 CTD PMID:30885713 NCBI chr 6:66,512,205...66,518,091
Ensembl chr 6:66,512,374...66,524,204 		JBrowse link
G Map2k3 mitogen-activated protein kinase kinase 3 increases expression ISO Camptothecin results in increased expression of MAP2K3 mRNA CTD PMID:17374387 NCBI chr11:60,822,880...60,843,637
Ensembl chr11:60,822,859...60,843,637 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 decreases expression ISO Camptothecin results in decreased expression of MAP3K5 mRNA CTD PMID:17374387 NCBI chr10:19,809,847...20,018,496
Ensembl chr10:19,810,218...20,018,499 		JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 decreases response to substance ISO MAP3K7 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 4:31,963,659...32,023,470
Ensembl chr 4:31,964,097...32,023,467 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO [Camptothecin co-treated with Nicotine] results in increased phosphorylation of MAPK1 protein CTD PMID:24095863 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO [Camptothecin co-treated with Nicotine] results in increased phosphorylation of MAPK3 protein CTD PMID:24095863 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions		 ISO Camptothecin results in increased phosphorylation of MAPK8 protein
MAPK8 protein affects the reaction [Camptothecin results in increased activity of SP1 protein]; MAPK8 protein affects the reaction [Camptothecin results in increased expression of CCNB1 protein]; MAPK8 protein affects the reaction [Camptothecin results in increased expression of CDK1 protein]; MAPK8 protein affects the reaction [Camptothecin results in increased expression of MAD2L1 protein]; MAPK8 protein affects the reaction [Camptothecin results in increased phosphorylation of JUN protein]		 CTD PMID:30885713 PMID:31255635 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO Camptothecin results in increased phosphorylation of MAPK9 protein CTD PMID:15585644 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248 		JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO Camptothecin results in decreased expression of MAPT mRNA; Camptothecin results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916 		JBrowse link
G Mdc1 mediator of DNA damage checkpoint 1 multiple interactions ISO [Aminacrine results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]; [Propyl Gallate results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]; Aminacrine inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]; Camptothecin results in increased activity of and affects the localization of MDC1 protein; Propyl Gallate inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein] CTD PMID:26928355 NCBI chr17:36,152,390...36,170,562
Ensembl chr17:36,152,407...36,170,562 		JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 increases expression ISO Camptothecin results in increased expression of MDM2 protein CTD PMID:17555331 NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases expression ISO Camptothecin results in decreased expression of MGMT mRNA CTD PMID:18492797 NCBI chr 7:136,496,315...136,732,001
Ensembl chr 7:136,496,343...136,731,995 		JBrowse link
G Mir138-1 microRNA 138-1 multiple interactions
increases response to substance		 ISO [MIR138-1 results in decreased expression of H2AX] which results in increased susceptibility to Camptothecin; H2AX gene mutant form inhibits the reaction [MIR138-1 results in increased susceptibility to Camptothecin] CTD PMID:21693595 NCBI chr 9:122,511,941...122,512,039
Ensembl chr 9:122,511,941...122,512,039 		JBrowse link
G Mir145a microRNA 145a increases expression
decreases expression		 ISO Camptothecin results in increased expression of MIR145 mRNA
Camptothecin results in decreased expression of MIR145 mRNA		 CTD PMID:24726431 NCBI chr18:61,780,896...61,780,965
Ensembl chr18:61,780,896...61,780,965 		JBrowse link
G Mir15a microRNA 15a increases expression
decreases expression		 ISO Camptothecin results in increased expression of MIR15A mRNA
Camptothecin results in decreased expression of MIR15A mRNA		 CTD PMID:24726431 NCBI chr14:61,869,476...61,869,559
Ensembl chr14:61,869,476...61,869,559 		JBrowse link
G Mir34a microRNA 34a increases expression ISO Camptothecin results in increased expression of MIR34A mRNA CTD PMID:24726431 NCBI chr 4:150,152,911...150,153,012
Ensembl chr 4:150,152,911...150,153,012 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases response to substance
decreases methylation		 ISO MMP9 mRNA results in decreased susceptibility to Camptothecin
Camptothecin results in decreased methylation of MMP9 gene		 CTD PMID:25269479 PMID:30720231 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Mre11a MRE11A homolog A, double strand break repair nuclease decreases expression ISO Camptothecin results in decreased expression of MRE11 mRNA CTD PMID:24792648 NCBI chr 9:14,695,971...14,748,421
Ensembl chr 9:14,695,950...14,748,419 		JBrowse link
G Mtmr2 myotubularin related protein 2 decreases response to substance ISO MTMR2 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 9:13,660,397...13,720,192
Ensembl chr 9:13,659,706...13,717,777 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression ISO Camptothecin results in decreased expression of MTOR protein CTD PMID:31255635 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Myc myelocytomatosis oncogene increases expression
affects localization
multiple interactions		 ISO Camptothecin results in increased expression of MYC mRNA
Camptothecin affects the localization of MYC protein
Camptothecin results in increased expression of and results in increased activity of MYC protein; MYC protein affects the reaction [Camptothecin results in increased expression of ATF4 protein]; MYC protein affects the reaction [Camptothecin results in increased expression of DDIT3 protein]; MYC protein affects the reaction [Camptothecin results in increased phosphorylation of EIF2AK3 protein]; MYC protein affects the reaction [Camptothecin results in increased phosphorylation of EIF2S1 protein]; TERT protein affects the reaction [Camptothecin results in increased expression of MYC protein]		 CTD PMID:30266318 PMID:30851366 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Myo1e myosin IE decreases expression ISO Camptothecin results in decreased expression of MYO1E mRNA CTD PMID:33770205 NCBI chr 9:70,114,632...70,307,349
Ensembl chr 9:70,114,632...70,307,048 		JBrowse link
G Ncam1 neural cell adhesion molecule 1 decreases response to substance ISO NCAM1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 9:49,413,434...49,710,909
Ensembl chr 9:49,413,436...49,710,225 		JBrowse link
G Nck2 non-catalytic region of tyrosine kinase adaptor protein 2 decreases expression ISO Camptothecin results in decreased expression of NCK2 mRNA CTD PMID:17374387 NCBI chr 1:43,484,643...43,609,678
Ensembl chr 1:43,483,739...43,609,675 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Camptothecin inhibits the reaction [Rifampin promotes the reaction [NCOA1 protein binds to NR1I2 protein]] CTD PMID:29356861 NCBI chr12:4,297,362...4,569,452
Ensembl chr12:4,297,362...4,527,182 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 multiple interactions ISO Camptothecin inhibits the reaction [NCOR2 protein binds to NR1I2 protein] CTD PMID:29356861 NCBI chr 5:125,094,217...125,256,302
Ensembl chr 5:125,094,217...125,256,283 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases activity
multiple interactions		 ISO Camptothecin results in increased activity of NFE2L2 protein
NFE2L2 protein affects the reaction [Camptothecin results in increased expression of TERT mRNA]		 CTD PMID:30851366 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Camptothecin inhibits the reaction [NCOR2 protein binds to NR1I2 protein]; Camptothecin inhibits the reaction [Rifampin promotes the reaction [NCOA1 protein binds to NR1I2 protein]]; Camptothecin inhibits the reaction [Rifampin results in increased activity of NR1I2 protein] CTD PMID:29356861 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Or7c70 olfactory receptor family 7 subfamily C member 70 decreases response to substance ISO OR7C2 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr10:78,682,785...78,683,747
Ensembl chr10:78,680,886...78,688,000 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions
increases cleavage
affects response to substance
decreases response to substance		 ISO
EXP		 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [Camptothecin results in increased cleavage of PARP1 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]; Camptothecin results in increased ADP-ribosylation of and results in increased degradation of PARP1 protein; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Camptothecin results in increased ADP-ribosylation of and results in increased degradation of PARP1 protein]; Nicotine inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]; PARP1 protein promotes the reaction [Camptothecin results in increased abundance of Poly Adenosine Diphosphate Ribose]; RBL2 protein inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]; THBS1 protein inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]; XRCC1 protein affects the reaction [PARP1 protein affects the susceptibility to Camptothecin]
[Camptothecin co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased cleavage of PARP1 protein; [veliparib results in decreased activity of PARP1 protein] which results in increased susceptibility to Camptothecin
Tetrachlorodibenzodioxin promotes the reaction [Camptothecin results in increased cleavage of PARP1 protein]
PARP1 results in decreased susceptibility to Camptothecin		 CTD PMID:11741290 PMID:15585644 PMID:16962673 PMID:18506790 PMID:19559722 More... NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO Camptothecin binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612 		JBrowse link
G Plk3 polo like kinase 3 increases expression ISO Camptothecin results in increased expression of PLK3 mRNA CTD PMID:17374387 NCBI chr 4:116,985,852...116,991,244
Ensembl chr 4:116,985,852...116,991,160 		JBrowse link
G Ppp1r16b protein phosphatase 1, regulatory subunit 16B decreases response to substance ISO PPP1R16B mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 2:158,508,653...158,608,254
Ensembl chr 2:158,507,318...158,608,254 		JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory inhibitor subunit 1B decreases response to substance ISO PPP1R1B protein alternative form results in decreased susceptibility to Camptothecin; PPP1R1B protein results in decreased susceptibility to Camptothecin CTD PMID:16061638 NCBI chr11:98,239,232...98,248,622
Ensembl chr11:98,239,230...98,248,622 		JBrowse link
G Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform multiple interactions ISO Camptothecin affects the localization of [PPP2R5E protein binds to PPP2CA protein] CTD PMID:25772433 NCBI chr11:51,989,651...52,013,576
Ensembl chr11:51,989,508...52,018,605 		JBrowse link
G Ppp2r1a protein phosphatase 2, regulatory subunit A, alpha affects localization
decreases response to substance		 ISO Camptothecin affects the localization of PPP2R1A protein
PPP2R1A mRNA results in decreased susceptibility to Camptothecin		 CTD PMID:25269479 PMID:25772433 NCBI chr17:21,165,716...21,186,167
Ensembl chr17:21,165,573...21,186,178 		JBrowse link
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha multiple interactions
decreases response to substance		 ISO PPP2R2A protein inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form]
PPP2R2A protein results in decreased susceptibility to Camptothecin		 CTD PMID:25772433 NCBI chr14:67,251,505...67,309,920
Ensembl chr14:67,251,505...67,309,893 		JBrowse link
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma multiple interactions
increases response to substance		 ISO PPP2R5C protein promotes the reaction [Camptothecin results in increased expression of H2AX protein modified form]
PPP2R5C protein results in increased susceptibility to Camptothecin		 CTD PMID:25772433 NCBI chr12:110,413,532...110,549,509
Ensembl chr12:110,413,554...110,549,496 		JBrowse link
G Ppp2r5e protein phosphatase 2, regulatory subunit B', epsilon multiple interactions
decreases response to substance		 ISO Camptothecin affects the localization of [PPP2R5E protein binds to PPP2CA protein]; PPP2R5E protein inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form]
PPP2R5E protein results in decreased susceptibility to Camptothecin		 CTD PMID:25772433 NCBI chr12:75,496,237...75,643,064
Ensembl chr12:75,497,655...75,643,019 		JBrowse link
G Prc1 protein regulator of cytokinesis 1 decreases expression ISO Camptothecin results in decreased expression of PRC1 mRNA CTD PMID:17374387 NCBI chr 7:79,944,224...79,966,007
Ensembl chr 7:79,944,198...79,966,007 		JBrowse link
G Psd3 pleckstrin and Sec7 domain containing 3 decreases expression ISO Camptothecin results in decreased expression of PSD3 mRNA CTD PMID:33770205 NCBI chr 8:68,141,728...68,664,740
Ensembl chr 8:68,141,734...68,664,679 		JBrowse link
G Ptar1 protein prenyltransferase alpha subunit repeat containing 1 decreases response to substance ISO PTAR1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr19:23,664,728...23,710,249
Ensembl chr19:23,664,793...23,709,032 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO Camptothecin results in decreased expression of and results in decreased phosphorylation of PTEN protein CTD PMID:30885713 NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560 		JBrowse link
G Ptpro protein tyrosine phosphatase receptor type O decreases response to substance ISO PTPRO mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 6:137,229,189...137,440,251
Ensembl chr 6:137,229,317...137,440,231 		JBrowse link
G Rad50 RAD50 double strand break repair protein decreases expression ISO Camptothecin results in decreased expression of RAD50 mRNA CTD PMID:24792648 NCBI chr11:53,540,346...53,598,146
Ensembl chr11:53,540,346...53,598,146 		JBrowse link
G Rad51 RAD51 recombinase decreases expression ISO Camptothecin results in decreased expression of RAD51 mRNA; Camptothecin results in decreased expression of RAD51 protein CTD PMID:10344722 PMID:24792648 NCBI chr 2:118,943,295...118,966,554
Ensembl chr 2:118,943,274...118,977,926 		JBrowse link
G Rad51c RAD51 paralog C increases response to substance ISO RAD51C gene mutant form results in increased susceptibility to Camptothecin CTD PMID:20400963 NCBI chr11:87,267,471...87,295,780
Ensembl chr11:87,267,471...87,295,780 		JBrowse link
G Rara retinoic acid receptor, alpha increases methylation ISO Camptothecin results in increased methylation of RARA gene CTD PMID:30720231 NCBI chr11:98,818,626...98,865,768
Ensembl chr11:98,818,644...98,865,768 		JBrowse link
G Rb1 RB transcriptional corepressor 1 increases phosphorylation
affects response to substance		 ISO
EXP		 Camptothecin results in increased phosphorylation of RB1 protein
RB1 protein affects the susceptibility to Camptothecin		 CTD PMID:14647467 PMID:14704340 PMID:15064736 PMID:15585644 NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262 		JBrowse link
G Rbl1 RB transcriptional corepressor like 1 decreases expression ISO Camptothecin results in decreased expression of RBL1 protein CTD PMID:15585644 NCBI chr 2:156,987,813...157,046,454
Ensembl chr 2:156,987,813...157,046,454 		JBrowse link
G Rbl2 RB transcriptional corepressor like 2 multiple interactions
decreases response to substance		 ISO RBL2 protein inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]
RBL2 protein results in decreased susceptibility to Camptothecin		 CTD PMID:15585644 NCBI chr 8:91,796,685...91,850,472
Ensembl chr 8:91,796,685...91,850,472 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) increases response to substance
multiple interactions		 ISO
EXP		 RELA results in increased susceptibility to Camptothecin
Camptothecin inhibits the reaction [RELA protein binds to CREBBP protein]; pifithrin inhibits the reaction [Camptothecin inhibits the reaction [RELA protein binds to CREBBP protein]]
Camptothecin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] affects the localization of and results in increased phosphorylation of RELA protein]
Camptothecin results in increased expression of and results in decreased phosphorylation of RELA protein; Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in decreased phosphorylation of RELA protein]; Diethylhexyl Phthalate promotes the reaction [Camptothecin results in increased expression of RELA protein]		 CTD PMID:13679428 PMID:21737676 PMID:25449198 PMID:36394428 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Ret ret proto-oncogene decreases expression ISO Camptothecin results in decreased expression of RET protein CTD PMID:17555550 NCBI chr 6:118,128,709...118,174,705
Ensembl chr 6:118,128,706...118,174,679 		JBrowse link
G Rnf31 ring finger protein 31 decreases response to substance ISO RNF31 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr14:55,829,199...55,841,131
Ensembl chr14:55,829,165...55,841,150 		JBrowse link
G Rps6 ribosomal protein S6 increases expression EXP Camptothecin results in increased expression of RPS6 protein modified form CTD PMID:29384525 NCBI chr 4:86,772,336...86,775,604
Ensembl chr 4:86,772,897...86,775,649 		JBrowse link
G Rrm2 ribonucleotide reductase M2 multiple interactions
increases expression		 EXP 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Camptothecin results in increased expression of RRM2 protein]; 7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased expression of RRM2 mRNA]; 7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased expression of RRM2 protein]; Caffeine inhibits the reaction [Camptothecin results in increased expression of RRM2 mRNA]; Caffeine inhibits the reaction [Camptothecin results in increased expression of RRM2 protein]; E2F1 protein promotes the reaction [Camptothecin results in increased expression of RRM2 protein]
Camptothecin results in increased expression of RRM2 mRNA; Camptothecin results in increased expression of RRM2 protein		 CTD PMID:22403396 NCBI chr12:24,758,253...24,764,145
Ensembl chr12:24,758,240...24,764,145 		JBrowse link
G Rwdd3 RWD domain containing 3 increases expression ISO Camptothecin results in increased expression of RWDD3 mRNA CTD PMID:33770205 NCBI chr 3:120,949,046...120,965,427
Ensembl chr 3:120,949,047...120,965,344 		JBrowse link
G Sdc1 syndecan 1 increases expression ISO Camptothecin results in increased expression of SDC1 mRNA CTD PMID:17374387 NCBI chr12:8,821,396...8,843,716
Ensembl chr12:8,821,323...8,843,715 		JBrowse link
G Sel1l sel-1 suppressor of lin-12-like (C. elegans) decreases response to substance ISO SEL1L mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr12:91,772,817...91,815,931
Ensembl chr12:91,772,817...91,815,931 		JBrowse link
G Sgtb small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta decreases expression ISO Camptothecin results in decreased expression of SGTB mRNA CTD PMID:33770205 NCBI chr13:104,246,233...104,278,369
Ensembl chr13:104,246,249...104,278,243 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression		 ISO [SIRT1 mutant form co-treated with Camptothecin] results in increased acetylation of TP53 protein; Camptothecin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of SIRT1 protein]
Camptothecin results in decreased expression of SIRT1 protein		 CTD PMID:24726431 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Slc2a12 solute carrier family 2 (facilitated glucose transporter), member 12 increases methylation ISO Camptothecin results in increased methylation of SLC2A12 gene CTD PMID:30720231 NCBI chr10:22,488,821...22,579,779
Ensembl chr10:22,520,910...22,580,184 		JBrowse link
G Smn1 survival motor neuron 1 multiple interactions
increases response to substance		 ISO SMN1 mRNA affects the reaction [Camptothecin results in increased activity of CASP3 protein]
SMN1 protein results in increased susceptibility to Camptothecin		 CTD PMID:15862279 NCBI chr13:100,259,713...100,274,206
Ensembl chr13:100,261,360...100,274,198 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3, neutral increases expression ISO Camptothecin results in increased expression of SMPD3 mRNA CTD PMID:19698806 NCBI chr 8:106,979,180...107,064,597
Ensembl chr 8:106,979,180...107,064,620 		JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions
increases expression		 ISO Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of SOD1 protein] CTD PMID:30720231 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions
increases expression		 ISO Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of SOD2 protein] CTD PMID:30720231 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Sox11 SRY (sex determining region Y)-box 11 increases methylation ISO Camptothecin results in increased methylation of SOX11 gene CTD PMID:30720231 NCBI chr12:27,384,267...27,392,717
Ensembl chr12:27,384,263...27,392,573 		JBrowse link
G Sox12 SRY (sex determining region Y)-box 12 increases methylation ISO Camptothecin results in increased methylation of SOX12 gene CTD PMID:30720231 NCBI chr 2:152,235,531...152,239,966
Ensembl chr 2:152,235,531...152,239,983 		JBrowse link
G Sox17 SRY (sex determining region Y)-box 17 increases methylation ISO Camptothecin results in increased methylation of SOX17 gene CTD PMID:30720231 NCBI chr 1:4,561,154...4,567,624
Ensembl chr 1:4,561,154...4,567,577 		JBrowse link
G Sox3 SRY (sex determining region Y)-box 3 increases methylation ISO Camptothecin results in increased methylation of SOX3 gene CTD PMID:30720231 NCBI chr  X:59,934,972...59,937,045
Ensembl chr  X:59,934,972...59,937,036 		JBrowse link
G Sox4 SRY (sex determining region Y)-box 4 increases methylation ISO Camptothecin results in increased methylation of SOX4 gene CTD PMID:30720231 NCBI chr13:29,132,902...29,137,682
Ensembl chr13:29,132,902...29,137,696 		JBrowse link
G Sox8 SRY (sex determining region Y)-box 8 increases methylation ISO Camptothecin results in increased methylation of SOX8 gene CTD PMID:30720231 NCBI chr17:25,784,865...25,789,666
Ensembl chr17:25,784,634...25,789,726 		JBrowse link
G Sp1 trans-acting transcription factor 1 multiple interactions
increases activity
increases expression		 ISO Acetylcysteine inhibits the reaction [Camptothecin results in increased expression of SP1 mRNA]; Camptothecin results in increased activity of and affects the localization of SP1 protein; Camptothecin results in increased expression of and results in increased activity of SP1 protein; MAPK8 protein affects the reaction [Camptothecin results in increased activity of SP1 protein]; mithramycin A inhibits the reaction [Camptothecin results in increased activity of SP1 protein]; TERT protein affects the reaction [Camptothecin results in increased expression of SP1 protein] CTD PMID:11261509 PMID:30851366 PMID:30885713 NCBI chr15:102,314,751...102,344,839
Ensembl chr15:102,314,578...102,344,839 		JBrowse link
G Sp3 trans-acting transcription factor 3 increases activity
multiple interactions		 ISO Camptothecin results in increased activity of SP3 protein
mithramycin A inhibits the reaction [Camptothecin results in increased activity of SP3 protein]		 CTD PMID:11261509 NCBI chr 2:72,766,774...72,810,790
Ensembl chr 2:72,766,771...72,810,790 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases degradation		 ISO ATG5 mutant form inhibits the reaction [Camptothecin results in increased degradation of SQSTM1 protein]; Camptothecin inhibits the reaction [Cannabidiol results in increased expression of SQSTM1 mRNA] CTD PMID:22927544 PMID:34302491 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
G Srgap3 SLIT-ROBO Rho GTPase activating protein 3 decreases expression ISO Camptothecin results in decreased expression of SRGAP3 mRNA CTD PMID:33770205 NCBI chr 6:112,694,932...112,924,466
Ensembl chr 6:112,694,932...112,924,227 		JBrowse link
G Srxn1 sulfiredoxin 1 homolog (S. cerevisiae) increases expression EXP Camptothecin results in increased expression of SRXN1 mRNA CTD PMID:22003191 NCBI chr 2:151,946,738...151,953,296
Ensembl chr 2:151,947,436...151,953,296 		JBrowse link
G Stambpl1 STAM binding protein like 1 increases methylation ISO Camptothecin results in increased methylation of STAMBPL1 gene CTD PMID:30720231 NCBI chr19:34,169,629...34,217,733
Ensembl chr19:34,169,629...34,217,733 		JBrowse link
G Styxl1 serine/threonine/tyrosine interacting-like 1 decreases response to substance ISO STYXL1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 5:135,776,074...135,807,277
Ensembl chr 5:135,776,074...135,807,239 		JBrowse link
G Suv39h1 suppressor of variegation 3-9 1 increases expression ISO Camptothecin results in increased expression of SUV39H1 mRNA CTD PMID:33770205 NCBI chr  X:7,927,401...7,940,994
Ensembl chr  X:7,927,410...7,940,999 		JBrowse link
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 decreases response to substance ISO TAB2 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr10:7,781,412...7,832,039
Ensembl chr10:7,781,417...7,831,994 		JBrowse link
G Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) increases expression ISO Camptothecin results in increased expression of TAP1 mRNA CTD PMID:17374387 NCBI chr17:34,406,530...34,416,199
Ensembl chr17:34,406,527...34,416,199 		JBrowse link
G Tax1bp3 Tax1 (human T cell leukemia virus type I) binding protein 3 increases expression ISO Camptothecin results in increased expression of TAX1BP3 mRNA CTD PMID:17374387 NCBI chr11:73,067,909...73,072,872
Ensembl chr11:73,067,909...73,073,988 		JBrowse link
G Tbc1d16 TBC1 domain family, member 16 decreases expression ISO Camptothecin results in decreased expression of TBC1D16 mRNA CTD PMID:33770205 NCBI chr11:119,033,869...119,119,354
Ensembl chr11:119,033,871...119,119,325 		JBrowse link
G Tdp1 tyrosyl-DNA phosphodiesterase 1 multiple interactions ISO TDP1 protein inhibits the reaction [Camptothecin results in increased expression of H2AX protein]; TDP1 protein inhibits the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]] CTD PMID:21227924 NCBI chr12:99,850,767...99,921,482
Ensembl chr12:99,850,776...99,921,478 		JBrowse link
G Tert telomerase reverse transcriptase multiple interactions
increases expression		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Camptothecin results in increased phosphorylation of TERT protein]; Acetylcysteine inhibits the reaction [Camptothecin results in increased expression of TERT protein]; Camptothecin results in increased expression of and results in increased phosphorylation of TERT protein; Glutathione inhibits the reaction [Camptothecin results in increased expression of TERT protein]; NFE2L2 protein affects the reaction [Camptothecin results in increased expression of TERT mRNA]; TERT protein affects the reaction [Camptothecin results in increased expression of MYC protein]; TERT protein affects the reaction [Camptothecin results in increased expression of SP1 protein]; Wortmannin inhibits the reaction [Camptothecin results in increased phosphorylation of TERT protein] CTD PMID:30851366 NCBI chr13:73,775,030...73,797,962
Ensembl chr13:73,775,030...73,797,962 		JBrowse link
G Thbs1 thrombospondin 1 decreases expression
decreases secretion
multiple interactions		 ISO Camptothecin results in decreased expression of THBS1 mRNA
Camptothecin results in decreased secretion of THBS1 protein
THBS1 protein inhibits the reaction [Camptothecin results in increased activity of CASP3 protein]; THBS1 protein inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]		 CTD PMID:16962673 NCBI chr 2:117,942,357...117,957,614
Ensembl chr 2:117,942,357...117,957,614 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Camptothecin binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr11:98,631,539...98,659,832
Ensembl chr11:98,631,464...98,659,832 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Camptothecin binds to and results in decreased activity of THRB protein CTD PMID:25752796 NCBI chr14:4,429,599...4,810,538
Ensembl chr14:4,431,611...4,809,435 		JBrowse link
G Tmem250 transmembrane protein 250 increases expression ISO Camptothecin results in increased expression of TMEM250 mRNA CTD PMID:33770205 NCBI chr 2:26,026,819...26,030,518
Ensembl chr 2:26,026,826...26,030,533 		JBrowse link
G Tnfsf9 tumor necrosis factor (ligand) superfamily, member 9 increases expression ISO Camptothecin results in increased expression of TNFSF9 mRNA CTD PMID:17374387 NCBI chr17:57,412,113...57,414,757
Ensembl chr17:57,412,325...57,414,757 		JBrowse link
G Top1 topoisomerase (DNA) I multiple interactions
decreases response to substance
decreases activity		 ISO [Ciprofloxacin co-treated with Camptothecin] results in decreased activity of TOP1 protein; [moxifloxacin co-treated with Camptothecin] results in decreased activity of TOP1 protein
TOP1 protein mutant form results in decreased susceptibility to Camptothecin
Camptothecin analog results in decreased activity of TOP1 protein; Camptothecin results in decreased activity of TOP1 protein		 CTD PMID:12097280 PMID:18191106 PMID:20600288 PMID:21056033 PMID:21227924 More... NCBI chr 2:160,487,901...160,564,684
Ensembl chr 2:160,487,808...160,564,684 		JBrowse link
G Traf6 TNF receptor-associated factor 6 decreases response to substance ISO TRAF6 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 2:101,508,765...101,532,013
Ensembl chr 2:101,508,774...101,532,014 		JBrowse link
G Trim28 tripartite motif-containing 28 increases expression ISO Camptothecin results in increased expression of TRIM28 protein modified form CTD PMID:25977998 NCBI chr 7:12,758,079...12,764,959
Ensembl chr 7:12,733,041...12,764,962 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions
increases glutathionylation
increases activity
increases phosphorylation
increases response to substance
increases expression
decreases acetylation
affects response to substance
decreases response to substance		 ISO
EXP		 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole promotes the reaction [Camptothecin results in increased expression of TP53 protein]; [SIRT1 mutant form co-treated with Camptothecin] results in increased acetylation of TP53 protein; Acetylcysteine inhibits the reaction [Camptothecin results in increased expression of TP53 protein modified form]; Camptothecin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased acetylation of TP53 protein]; Camptothecin results in increased stability of and results in increased expression of and results in increased phosphorylation of and results in increased activity of TP53 protein; nutlin 3 inhibits the reaction [Camptothecin results in increased expression of TP53 protein]; S-ethyl glutathione inhibits the reaction [Camptothecin results in increased expression of TP53 protein modified form]
Camptothecin results in increased glutathionylation of TP53 protein
Camptothecin results in increased activity of TP53 protein
Camptothecin results in increased phosphorylation of TP53 protein
Camptothecin promotes the reaction [TP53 protein binds to CREBBP protein]; pifithrin inhibits the reaction [Camptothecin promotes the reaction [TP53 protein binds to CREBBP protein]]; pifithrin inhibits the reaction [Camptothecin results in increased activity of TP53 protein]
TP53 protein results in increased susceptibility to Camptothecin
Camptothecin results in decreased acetylation of TP53 protein
TRP53 protein affects the susceptibility to Camptothecin
TP53 mutant form results in decreased susceptibility to Camptothecin; TP53 protein mutant form results in decreased susceptibility to Camptothecin; TP53 protein results in decreased susceptibility to Camptothecin		 CTD PMID:9673414 PMID:10692111 PMID:11279278 PMID:11741290 PMID:12082016 More... NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Trp63 transformation related protein 63 decreases expression ISO Camptothecin results in decreased expression of TP63 protein alternative form CTD PMID:23376119 NCBI chr16:25,502,513...25,710,842
Ensembl chr16:25,502,513...25,710,852 		JBrowse link
G Tsg101 tumor susceptibility gene 101 decreases response to substance ISO TSG101 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 7:46,538,693...46,569,716
Ensembl chr 7:46,538,697...46,569,717 		JBrowse link
G Tulp4 TUB like protein 4 decreases expression ISO Camptothecin results in decreased expression of TULP4 mRNA CTD PMID:33770205 NCBI chr17:6,156,528...6,290,912
Ensembl chr17:6,156,712...6,301,403 		JBrowse link
G Twf1 twinfilin actin binding protein 1 decreases response to substance ISO TWF1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr15:94,475,829...94,487,727
Ensembl chr15:94,475,832...94,487,770 		JBrowse link
G Tyms thymidylate synthase increases expression ISO Camptothecin results in increased expression of TYMS mRNA CTD PMID:16568373 NCBI chr 5:30,243,544...30,279,261
Ensembl chr 5:30,263,200...30,278,615 		JBrowse link
G Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B decreases methylation ISO Camptothecin results in decreased methylation of UGT1A6 gene CTD PMID:30720231 NCBI chr 1:88,030,979...88,146,720
Ensembl chr 1:88,030,974...88,146,725 		JBrowse link
G Upf1 UPF1 RNA helicase and ATPase decreases response to substance ISO UPF1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 8:70,784,143...70,806,418
Ensembl chr 8:70,784,175...70,805,928 		JBrowse link
G Usp5 ubiquitin specific peptidase 5 (isopeptidase T) decreases response to substance ISO USP5 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 6:124,791,982...124,806,404
Ensembl chr 6:124,791,982...124,806,447 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
decreases response to substance		 ISO Camptothecin results in decreased expression of VEGFA protein
VEGFA protein results in decreased susceptibility to Camptothecin		 CTD PMID:16356833 PMID:20116850 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions
decreases response to substance		 ISO
EXP		 [Butyrates co-treated with Camptothecin] results in decreased expression of XIAP protein; [Camptothecin co-treated with FAS protein] results in decreased expression of XIAP protein
XIAP protein results in decreased susceptibility to Camptothecin
Camptothecin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of XIAP protein]		 CTD PMID:16061681 PMID:16211302 PMID:19633536 PMID:25449198 NCBI chr  X:41,148,483...41,198,541
Ensembl chr  X:41,148,556...41,198,533 		JBrowse link
G Xrcc1 X-ray repair complementing defective repair in Chinese hamster cells 1 affects response to substance
multiple interactions		 ISO XRCC1 protein affects the susceptibility to Camptothecin
[XRCC1 protein affects the susceptibility to Camptothecin] which affects the abundance of NAD; olaparib affects the reaction [[XRCC1 protein affects the susceptibility to Camptothecin] which affects the abundance of NAD]; veliparib affects the reaction [[XRCC1 protein affects the susceptibility to Camptothecin] which affects the abundance of NAD]; XRCC1 protein affects the reaction [PARP1 protein affects the susceptibility to Camptothecin]		 CTD PMID:35778544 NCBI chr 7:24,246,124...24,272,863
Ensembl chr 7:24,245,714...24,272,865 		JBrowse link
G Xrcc3 X-ray repair complementing defective repair in Chinese hamster cells 3 decreases expression ISO Camptothecin results in decreased expression of XRCC3 mRNA CTD PMID:24792648 NCBI chr12:111,769,626...111,780,326
Ensembl chr12:111,769,626...111,780,307 		JBrowse link
G Xrcc4 X-ray repair complementing defective repair in Chinese hamster cells 4 decreases response to substance
increases methylation		 ISO XRCC4 results in decreased susceptibility to Camptothecin
Camptothecin results in increased methylation of XRCC4 gene		 CTD PMID:21785230 PMID:30720231 NCBI chr13:89,997,033...90,237,727
Ensembl chr13:89,922,146...90,237,727 		JBrowse link
G Yars2 tyrosyl-tRNA synthetase 2 (mitochondrial) increases expression ISO Camptothecin results in increased expression of YARS2 mRNA CTD PMID:33770205 NCBI chr16:16,120,829...16,127,504
Ensembl chr16:16,120,829...16,127,504 		JBrowse link
G Zap70 zeta-chain (TCR) associated protein kinase decreases response to substance ISO ZAP70 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 1:36,800,912...36,821,899
Ensembl chr 1:36,800,879...36,821,899 		JBrowse link
G Zc3hc1 zinc finger, C3HC type 1 decreases response to substance ISO ZC3HC1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 6:30,366,383...30,391,019
Ensembl chr 6:30,366,379...30,391,027 		JBrowse link
G Zfp282 zinc finger protein 282 increases expression ISO Camptothecin results in increased expression of ZNF282 mRNA CTD PMID:33770205 NCBI chr 6:47,853,433...47,885,419
Ensembl chr 6:47,854,138...47,885,419 		JBrowse link
G Zfp383 zinc finger protein 383 increases expression ISO Camptothecin results in increased expression of ZNF383 mRNA CTD PMID:33770205 NCBI chr 7:29,607,705...29,616,238
Ensembl chr 7:29,607,648...29,616,238 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      biological role 22162
        aetiopathogenetic role 21266
          genotoxin 19526
            camptothecin 224
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            heteroorganic entity 21482
                              organochalcogen compound 20966
                                organooxygen compound 20806
                                  ester 18216
                                    carboxylic ester 17229
                                      lactone 13001
                                        delta-lactone 3949
                                          camptothecin 224
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