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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:camptothecin
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Accession:CHEBI:27656 term browser browse the term
Definition:A pyranoindolizinoquinoline that is pyrano[3',4':6,7]indolizino[1,2-b]quinoline which is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the S enantiomer).
Synonyms:exact_synonym: (4S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
 related_synonym: (S)-(+)-camptothecin;   20(S)-camptothecine;   21,22-Secocamptothecin-21-oic acid lactone;   CPT;   Camptothecine;   D-camptothecin;   Formula=C20H16N2O4;   InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1;   InChIKey=VSJKWCGYPAHWDS-FQEVSTJZSA-N;   SMILES=CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccccc4cc3Cn1c2=O
 alt_id: CHEBI:22997;   CHEBI:3343
 xref: Beilstein:6075662;   CAS:7689-03-4;   DrugBank:DB04690;   KEGG:C01897;   KNApSAcK:C00002145;   LINCS:LSM-4611
 xref_mesh: MESH:D002166
 xref: PDBeChem:EHD;   PMID:11024478;   PMID:11549373;   PMID:23344961;   PMID:23474217;   PMID:23676007;   PMID:8965250;   Reaxys:6075662;   Wikipedia:Camptothecin


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camptothecin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
multiple interactions
ISO Camptothecin results in decreased expression of ABCB1 mRNA; Camptothecin results in decreased expression of ABCB1 protein
Camptothecin inhibits the reaction [Rifampin results in increased expression of ABCB1 mRNA]
CTD PMID:10692111, PMID:29356861 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases response to substance
multiple interactions
ISO ABCC1 protein results in decreased susceptibility to Camptothecin analog
Camptothecin inhibits the reaction [ABCC1 results in decreased susceptibility to Daunorubicin]
CTD PMID:11778547, PMID:12115804 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Acvr1b activin A receptor type 1B increases methylation ISO Camptothecin results in increased methylation of ACVR1B gene CTD PMID:30720231 NCBI chr 7:142,817,174...142,858,365
Ensembl chr 7:142,817,157...142,860,572
JBrowse link
G Adam19 ADAM metallopeptidase domain 19 decreases response to substance ISO ADAM19 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr10:31,146,107...31,240,582
Ensembl chr10:31,146,107...31,240,582
JBrowse link
G Agap1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 increases methylation ISO Camptothecin results in increased methylation of AGAP1 gene CTD PMID:30720231 NCBI chr 9:96,718,901...97,034,400
Ensembl chr 9:96,621,586...97,030,163
JBrowse link
G Agrn agrin increases expression ISO Camptothecin results in increased expression of AGRN mRNA CTD PMID:17374387 NCBI chr 5:173,589,910...173,622,813
Ensembl chr 5:173,589,819...173,622,645
JBrowse link
G Agrp agouti related neuropeptide decreases response to substance ISO AGRP mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr19:37,525,941...37,584,875
Ensembl chr19:37,526,419...37,528,011
JBrowse link
G Aifm3 apoptosis inducing factor, mitochondria associated 3 decreases response to substance ISO AIFM3 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr11:87,364,452...87,380,705
Ensembl chr11:87,366,621...87,380,704
JBrowse link
G Akap13 A-kinase anchoring protein 13 decreases response to substance ISO AKAP13 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 1:137,089,558...137,315,272
Ensembl chr 1:137,014,272...137,315,272
JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects phosphorylation
increases phosphorylation
multiple interactions
ISO Camptothecin affects the phosphorylation of AKT1 protein
Camptothecin results in increased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Camptothecin results in increased phosphorylation of AKT1 protein]; Nicotine affects the reaction [Camptothecin affects the phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Camptothecin results in increased phosphorylation of AKT1 protein]
CTD PMID:24095863, PMID:30851366 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin affects binding
multiple interactions
ISO Camptothecin analog binds to ALB protein; Camptothecin binds to ALB protein
CTSB protein results in increased cleavage of [Camptothecin analog binds to ALB protein]
CTD PMID:10803926, PMID:17378599 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Alms1 ALMS1, centrosome and basal body associated protein decreases methylation ISO Camptothecin results in decreased methylation of ALMS1 gene CTD PMID:30720231 NCBI chr 4:117,371,544...117,472,310
Ensembl chr 4:117,371,659...117,472,198
JBrowse link
G Anxa4 annexin A4 increases expression ISO Camptothecin results in increased expression of ANXA4 mRNA CTD PMID:17374387 NCBI chr 4:118,538,775...118,595,591
Ensembl chr 4:118,538,777...118,595,580
JBrowse link
G Apc APC regulator of WNT signaling pathway increases methylation ISO Camptothecin results in increased methylation of APC gene CTD PMID:30720231 NCBI chr18:27,011,710...27,106,323
Ensembl chr18:27,047,382...27,105,531
JBrowse link
G Ar androgen receptor multiple interactions ISO Camptothecin binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Artn artemin decreases response to substance ISO ARTN mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 5:136,759,717...136,765,036
Ensembl chr 5:136,759,717...136,762,986
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression
ISO Glutathione inhibits the reaction [Camptothecin results in increased expression of ATF4 protein]; MYC protein affects the reaction [Camptothecin results in increased expression of ATF4 protein] CTD PMID:30266318 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atg5 autophagy related 5 multiple interactions ISO ATG5 mutant form inhibits the reaction [Camptothecin results in increased degradation of SQSTM1 protein] CTD PMID:22927544 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Atg7 autophagy related 7 multiple interactions
increases expression
ISO Egtazic Acid inhibits the reaction [Camptothecin results in increased expression of ATG7 protein]; EIF2S1 protein affects the reaction [Camptothecin results in increased expression of ATG7 protein]; staurosporine aglycone inhibits the reaction [Camptothecin results in increased expression of ATG7 protein] CTD PMID:30266318 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Atm ATM serine/threonine kinase decreases expression
increases expression
multiple interactions
ISO Camptothecin results in decreased expression of ATM mRNA
Camptothecin results in increased expression of ATM protein modified form
Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of ATM protein modified form]; ESR1 promotes the reaction [Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of ATM protein modified form]]
CTD PMID:24792648, PMID:30720231 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Atr ATR serine/threonine kinase decreases response to substance
increases phosphorylation
multiple interactions
ISO ATR mRNA results in decreased susceptibility to Camptothecin; ATR protein results in decreased susceptibility to Camptothecin
Camptothecin results in increased phosphorylation of ATR protein
3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [Camptothecin results in increased phosphorylation of ATR protein]
CTD PMID:25269479, PMID:30555576 NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions
decreases expression
ISO Folic Acid inhibits the reaction [Camptothecin results in decreased expression of BAK1 mRNA] CTD PMID:30581319 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
decreases expression
increases expression
increases activity
ISO
EXP
[Camptothecin co-treated with 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole] results in decreased expression of BAX protein; Camptothecin affects the cleavage of and results in decreased expression of BAX protein; Folic Acid inhibits the reaction [Camptothecin results in decreased expression of BAX mRNA]
Camptothecin results in decreased expression of BAX mRNA; Camptothecin results in decreased expression of BAX protein
pifithrin inhibits the reaction [Camptothecin results in increased expression of BAX protein]
Camptothecin results in increased activity of BAX protein
CTD PMID:11279278, PMID:15665116, PMID:17555331, PMID:19481069, PMID:30581319, PMID:30885713 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 affects response to substance ISO BBC3 protein affects the susceptibility to Camptothecin CTD PMID:20477944 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
decreases expression
decreases response to substance
ISO 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole promotes the reaction [Camptothecin results in decreased expression of BCL2 protein]; Folic Acid inhibits the reaction [Camptothecin results in decreased expression of BCL2 mRNA]
Camptothecin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of BCL2 protein]
Camptothecin results in increased expression of BCL2 mRNA
Camptothecin results in decreased expression of BCL2 mRNA; Camptothecin results in decreased expression of BCL2 protein
BCL2 results in decreased susceptibility to Camptothecin
CTD PMID:9664115, PMID:10692111, PMID:10896673, PMID:19481069, PMID:24726431, PMID:25449198, PMID:30581319 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases response to substance
decreases expression
multiple interactions
increases expression
EXP
ISO
BCL2L1 gene mutant form results in decreased susceptibility to Camptothecin
Camptothecin results in decreased expression of BCL2L1 mRNA
Folic Acid inhibits the reaction [Camptothecin results in decreased expression of BCL2L1 mRNA]
BCL2L1 mRNA results in decreased susceptibility to Camptothecin
Dexamethasone inhibits the reaction [Camptothecin results in decreased expression of BCL2L1 protein alternative form]; Mifepristone affects the reaction [Dexamethasone inhibits the reaction [Camptothecin results in decreased expression of BCL2L1 protein alternative form]]; Naphthoquinones analog promotes the reaction [Camptothecin results in increased expression of BCL2L1 protein]
CTD PMID:10970895, PMID:19339209, PMID:19497415, PMID:25269479, PMID:30581319 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression
ISO Egtazic Acid inhibits the reaction [Camptothecin results in increased expression of BECN1 protein]; EIF2S1 protein affects the reaction [Camptothecin results in increased expression of BECN1 protein]; staurosporine aglycone inhibits the reaction [Camptothecin results in increased expression of BECN1 protein] CTD PMID:30266318 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [Camptothecin co-treated with 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole] results in increased cleavage of and results in decreased expression of BID protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of BID protein; Camptothecin results in increased cleavage of and results in decreased expression of BID protein CTD PMID:19481069, PMID:19633536 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression
increases expression
ISO [Butyrates co-treated with Camptothecin] results in decreased expression of BIRC5 protein; [Folic Acid co-treated with Camptothecin] results in decreased expression of BIRC5 mRNA
Camptothecin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of BIRC5 protein]
Camptothecin results in decreased expression of BIRC5 mRNA
Camptothecin results in increased expression of BIRC5 mRNA
CTD PMID:16061681, PMID:24726431, PMID:25449198, PMID:30581319 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression
decreases response to substance
ISO Camptothecin results in decreased expression of BRCA1 mRNA
BRCA1 mRNA results in decreased susceptibility to Camptothecin
CTD PMID:10344722, PMID:25269479 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Brca2 BRCA2, DNA repair associated decreases expression ISO Camptothecin results in decreased expression of BRCA2 mRNA CTD PMID:10344722 NCBI chr12:503,660...544,754
Ensembl chr12:504,007...544,748
JBrowse link
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin increases expression ISO Camptothecin results in increased expression of BSCL2 mRNA CTD PMID:22003191 NCBI chr 1:225,035,956...225,046,137
Ensembl chr 1:225,037,737...225,046,040
JBrowse link
G Cab39 calcium binding protein 39 decreases expression ISO Camptothecin results in decreased expression of CAB39 mRNA CTD PMID:17374387 NCBI chr 9:92,834,327...92,895,778
Ensembl chr 9:92,834,357...92,895,778
JBrowse link
G Casp2 caspase 2 increases splicing
increases expression
ISO Camptothecin results in increased splicing of CASP2 mRNA
Camptothecin results in increased expression of CASP2 mRNA alternative form
CTD PMID:14757846 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
ISO
EXP
15-deoxyprostaglandin J2 promotes the reaction [Camptothecin results in increased activity of CASP3 protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole promotes the reaction [Camptothecin results in increased activity of CASP3 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Camptothecin results in increased activity of CASP3 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [Camptothecin results in increased activity of CASP3 protein]; [Camptothecin co-treated with FAS protein] results in increased activity of CASP3 protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of CASP3 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Camptothecin results in increased cleavage of CASP3 protein]; Camptothecin promotes the reaction [15-deoxyprostaglandin J2 results in increased activity of CASP3 protein]; Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased cleavage of CASP3 protein]; palbociclib inhibits the reaction [Camptothecin results in increased activity of CASP3 protein]; SMN1 mRNA affects the reaction [Camptothecin results in increased activity of CASP3 protein]; THBS1 protein inhibits the reaction [Camptothecin results in increased activity of CASP3 protein]
Cadmium Chloride inhibits the reaction [Camptothecin results in increased cleavage of CASP3 protein]; Cadmium inhibits the reaction [Camptothecin results in increased cleavage of CASP3 protein]; Dexamethasone inhibits the reaction [Camptothecin results in increased activity of CASP3 protein]; Naphthoquinones analog inhibits the reaction [Camptothecin results in increased activity of CASP3 protein]; Tetrachlorodibenzodioxin promotes the reaction [Camptothecin results in increased cleavage of CASP3 protein]
CTD PMID:10896673, PMID:15862279, PMID:15958570, PMID:16263807, PMID:16273314, PMID:16756956, PMID:16962673, PMID:18506790, PMID:19339209, PMID:19481069, PMID:19497415, PMID:19633536, PMID:21683069, PMID:22302033, PMID:24726431, PMID:24792648, PMID:25412314, PMID:25592883, PMID:25843524, PMID:29384525, PMID:30720231 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions
decreases expression
increases activity
ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Camptothecin results in increased activity of CASP7 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [Camptothecin results in increased activity of CASP7 protein]; palbociclib inhibits the reaction [Camptothecin results in increased activity of CASP7 protein]
Camptothecin results in decreased expression of CASP7 mRNA
CTD PMID:22302033, PMID:24726431, PMID:30581319 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions
decreases expression
increases expression
increases activity
affects cleavage
ISO
EXP
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Camptothecin results in increased activity of CASP8 protein]; [Camptothecin co-treated with FAS protein] results in increased activity of CASP8 protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of CASP8 protein; Lithium inhibits the reaction [Camptothecin results in increased activity of CASP8 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of CASP8 protein]
Camptothecin results in decreased expression of CASP8 mRNA
Naphthoquinones analog inhibits the reaction [Camptothecin results in increased activity of CASP8 protein]
Camptothecin affects the cleavage of CASP8 protein
CTD PMID:10896673, PMID:15475000, PMID:15958570, PMID:19497415, PMID:19633536, PMID:30581319, PMID:30885713 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
decreases expression
increases expression
increases cleavage
increases activity
ISO
EXP
[Camptothecin co-treated with FAS protein] results in increased activity of CASP9 protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of CASP9 protein; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of CASP9 protein]
Camptothecin results in decreased expression of CASP9 mRNA
Camptothecin results in increased cleavage of CASP9 protein
Camptothecin results in increased activity of CASP9 protein
benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Camptothecin results in increased cleavage of CASP9 protein]; Cadmium Chloride inhibits the reaction [Camptothecin results in increased activity of CASP9 protein]; Cadmium inhibits the reaction [Camptothecin results in increased activity of CASP9 protein]; Naphthoquinones analog inhibits the reaction [Camptothecin results in increased activity of CASP9 protein]
CTD PMID:10896673, PMID:15958570, PMID:16263807, PMID:19497415, PMID:19633536, PMID:24823293, PMID:30581319, PMID:30885713 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cav1 caveolin 1 decreases methylation ISO Camptothecin results in decreased methylation of CAV1 gene CTD PMID:30720231 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Camptothecin results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Camptothecin results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Camptothecin results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccna2 cyclin A2 multiple interactions
decreases expression
ISO [Folic Acid co-treated with Camptothecin] results in decreased expression of CCNA2 mRNA
Camptothecin results in decreased expression of CCNA2 mRNA
CTD PMID:30581319 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 multiple interactions
decreases expression
increases expression
ISO [Butyrates co-treated with Camptothecin] results in decreased expression of CCNB1 protein; CDKN1A protein affects the reaction [Camptothecin results in increased expression of CCNB1 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of CCNB1 protein]; MAPK8 protein affects the reaction [Camptothecin results in increased expression of CCNB1 protein]
Camptothecin results in decreased expression of CCNB1 protein
CTD PMID:16061681, PMID:23376119, PMID:30851366, PMID:30885713, PMID:31255635 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 affects localization ISO Camptothecin affects the localization of CCND1 protein CTD PMID:14647467 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 increases expression ISO Camptothecin results in increased expression of CCNE1 protein CTD PMID:30851366 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cdc20 cell division cycle 20 multiple interactions ISO Camptothecin promotes the reaction [MAD2L1 protein binds to CDC20 protein] CTD PMID:30885713 NCBI chr 5:137,260,728...137,264,931
Ensembl chr 5:137,260,739...137,265,015
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO Camptothecin results in increased expression of and results in increased activity of CDK1 protein; CDKN1A protein affects the reaction [Camptothecin results in increased activity of CDK1 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of and results in increased activity of CDK1 protein]; MAPK8 protein affects the reaction [Camptothecin results in increased expression of CDK1 protein] CTD PMID:30885713 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO Camptothecin results in increased phosphorylation of and results in decreased activity of CDK2 protein CTD PMID:15141020 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO Aspirin inhibits the reaction [Camptothecin results in increased expression of CDKN1A protein]; Camptothecin results in increased expression of and results in increased phosphorylation of CDKN1A protein; CDKN1A protein affects the reaction [Camptothecin results in increased activity of CDK1 protein]; CDKN1A protein affects the reaction [Camptothecin results in increased expression of CCNB1 protein]; CDKN1A protein affects the reaction [Camptothecin results in increased expression of MAD2L1 protein]
Camptothecin results in increased expression of CDKN1A mRNA; Camptothecin results in increased expression of CDKN1A protein
CTD PMID:9673414, PMID:17555331, PMID:19212664, PMID:24211769, PMID:30022047, PMID:30851366, PMID:30885713 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 increases expression ISO Camptothecin results in increased expression of CEACAM1 mRNA CTD PMID:17374387 NCBI chr 1:82,327,955...82,344,345
Ensembl chr 1:82,327,955...82,344,345
JBrowse link
G Cebpz CCAAT/enhancer binding protein zeta decreases expression ISO Camptothecin results in decreased expression of CEBPZ mRNA CTD PMID:17374387 NCBI chr 6:1,516,804...1,534,488
Ensembl chr 6:1,516,804...1,534,488
JBrowse link
G Cep85l centrosomal protein 85-like increases methylation ISO Camptothecin results in increased methylation of CEP85L gene CTD PMID:30720231 NCBI chr20:34,574,043...34,743,142
Ensembl chr20:34,575,950...34,684,418
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions ISO Camptothecin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of CFLAR protein] CTD PMID:25449198 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions
increases phosphorylation
decreases response to substance
increases expression
ISO 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein]; 7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased expression of CHEK1 mRNA]; 7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein]; Caffeine inhibits the reaction [Camptothecin results in increased expression of CHEK1 mRNA]; Caffeine inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein]
CHEK1 mRNA results in decreased susceptibility to Camptothecin
Camptothecin results in increased expression of CHEK1 protein modified form
3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [Camptothecin results in increased expression of CHEK1 protein modified form]; Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of CHEK1 protein modified form]
CTD PMID:21646468, PMID:22403396, PMID:25269479, PMID:30555576, PMID:30720231 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chek2 checkpoint kinase 2 increases expression
multiple interactions
increases phosphorylation
ISO Camptothecin results in increased expression of CHEK2 protein modified form
Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of CHEK2 protein modified form]
Camptothecin results in increased phosphorylation of CHEK2 protein
CTD PMID:21646468, PMID:25269479, PMID:25977998, PMID:30720231 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Clptm1l CLPTM1-like increases response to substance ISO CLPTM1L mutant form results in increased susceptibility to Camptothecin CTD PMID:22675468 NCBI chr 1:32,281,207...32,297,196
Ensembl chr 1:32,281,207...32,297,190
JBrowse link
G Crebbp CREB binding protein multiple interactions EXP Camptothecin inhibits the reaction [RELA protein binds to CREBBP protein]; Camptothecin promotes the reaction [TP53 protein binds to CREBBP protein]; pifithrin inhibits the reaction [Camptothecin inhibits the reaction [RELA protein binds to CREBBP protein]]; pifithrin inhibits the reaction [Camptothecin promotes the reaction [TP53 protein binds to CREBBP protein]] CTD PMID:13679428 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039
JBrowse link
G Crx cone-rod homeobox decreases response to substance ISO CRX mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 1:77,744,593...77,758,913
Ensembl chr 1:77,745,288...77,750,960
JBrowse link
G Ctsb cathepsin B multiple interactions ISO CTSB protein results in increased cleavage of [Camptothecin analog binds to ALB protein] CTD PMID:17378599 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Cycs cytochrome c, somatic multiple interactions
affects localization
ISO 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole promotes the reaction [Camptothecin affects the localization of CYCS protein] CTD PMID:19481069 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 decreases response to substance ISO CYP26B1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 4:116,261,796...116,278,615
Ensembl chr 4:116,261,796...116,278,615
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases expression
multiple interactions
ISO Camptothecin results in decreased expression of CYP2B6 mRNA
Camptothecin inhibits the reaction [Rifampin results in increased expression of CYP2B6 mRNA]
CTD PMID:29356861 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases expression
multiple interactions
ISO Camptothecin results in decreased expression of CYP2C8 mRNA
Camptothecin inhibits the reaction [Rifampin results in increased expression of CYP2C8 mRNA]
CTD PMID:29356861 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
decreases expression
increases expression
ISO Folic Acid inhibits the reaction [Camptothecin results in decreased expression of DDIT3 mRNA]; MYC protein affects the reaction [Camptothecin results in increased expression of DDIT3 protein] CTD PMID:30266318, PMID:30581319 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dgkz diacylglycerol kinase zeta decreases response to substance ISO DGKZ mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 3:80,844,002...80,886,487
Ensembl chr 3:80,844,005...80,875,817
JBrowse link
G Dpyd dihydropyrimidine dehydrogenase multiple interactions
decreases activity
decreases expression
ISO Camptothecin inhibits the reaction [Fluorouracil results in increased expression of DPYD mRNA]
Camptothecin results in decreased activity of DPYD protein
Camptothecin results in decreased expression of DPYD mRNA
CTD PMID:16568373 NCBI chr 2:221,823,692...222,694,627
Ensembl chr 2:221,823,687...222,694,627
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions
increases expression
ISO 7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased expression of E2F1 mRNA]; Caffeine inhibits the reaction [Camptothecin results in increased expression of E2F1 mRNA]; E2F1 protein promotes the reaction [Camptothecin results in increased expression of RRM2 protein] CTD PMID:22403396 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G Ei24 EI24, autophagy associated transmembrane protein increases expression ISO Camptothecin results in increased expression of EI24 mRNA CTD PMID:17374387 NCBI chr 8:39,254,883...39,271,238
Ensembl chr 8:39,254,889...39,266,959
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation
ISO Glutathione inhibits the reaction [Camptothecin results in increased phosphorylation of EIF2AK3 protein]; MYC protein affects the reaction [Camptothecin results in increased phosphorylation of EIF2AK3 protein] CTD PMID:30266318 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation
multiple interactions
ISO
EXP
Camptothecin results in increased phosphorylation of EIF2S1 protein
[Camptothecin co-treated with GW 506033X] results in increased phosphorylation of EIF2S1 protein
EIF2S1 protein affects the reaction [Camptothecin results in increased expression of ATG7 protein]; EIF2S1 protein affects the reaction [Camptothecin results in increased expression of BECN1 protein]; Glutathione inhibits the reaction [Camptothecin results in increased phosphorylation of EIF2S1 protein]; MYC protein affects the reaction [Camptothecin results in increased phosphorylation of EIF2S1 protein]
CTD PMID:19046382, PMID:30266318 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Ep300 E1A binding protein p300 decreases expression ISO Camptothecin results in decreased expression of EP300 mRNA; Camptothecin results in decreased expression of EP300 protein CTD PMID:10344722 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G Epm2aip1 EPM2A interacting protein 1 increases expression ISO Camptothecin results in increased expression of EPM2AIP1 mRNA CTD PMID:17374387 NCBI chr 8:119,524,039...119,531,387
Ensembl chr 8:119,524,039...119,531,387
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit multiple interactions
decreases expression
ISO ERCC1 protein promotes the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]]
Camptothecin results in decreased expression of ERCC1 mRNA
CTD PMID:21227924, PMID:24792648 NCBI chr 1:80,256,973...80,268,198
Ensembl chr 1:80,256,973...80,268,198
JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit multiple interactions
decreases response to substance
ISO ERCC4 protein promotes the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]]
ERCC4 protein results in decreased susceptibility to Camptothecin
CTD PMID:21227924 NCBI chr10:2,010,140...2,037,953
Ensembl chr10:2,010,648...2,037,891
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Camptothecin binds to and results in decreased activity of ESR1 protein; ESR1 promotes the reaction [Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of ATM protein modified form]]; ESR1 promotes the reaction [Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form]] CTD PMID:25752796, PMID:30720231 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Camptothecin binds to and results in decreased activity of ESR2 protein CTD PMID:25752796 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Camptothecin results in increased expression of and affects the localization of FAS protein]; [Camptothecin co-treated with FAS protein] results in decreased expression of XIAP protein; [Camptothecin co-treated with FAS protein] results in increased activity of CASP3 protein; [Camptothecin co-treated with FAS protein] results in increased activity of CASP8 protein; [Camptothecin co-treated with FAS protein] results in increased activity of CASP9 protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of BID protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of CASP3 protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of CASP8 protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of CASP9 protein; Camptothecin results in increased expression of and affects the localization of FAS protein; Lithium inhibits the reaction [Camptothecin results in increased expression of and affects the localization of FAS protein] CTD PMID:15475000, PMID:15958570, PMID:19633536 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fdxr ferredoxin reductase increases expression ISO Camptothecin results in increased expression of FDXR mRNA CTD PMID:17374387 NCBI chr10:103,817,724...103,826,413
Ensembl chr10:103,817,704...103,826,448
JBrowse link
G Fxn frataxin increases expression ISO Camptothecin results in increased expression of FXN protein CTD PMID:23418481 NCBI chr 1:242,123,975...242,152,834
Ensembl chr 1:242,123,975...242,152,834
JBrowse link
G Fzd1 frizzled class receptor 1 decreases methylation ISO Camptothecin results in decreased methylation of FZD1 gene CTD PMID:30720231 NCBI chr 4:26,470,864...26,475,262
Ensembl chr 4:26,470,864...26,475,262
JBrowse link
G Fzd8 frizzled class receptor 8 decreases methylation ISO Camptothecin results in decreased methylation of FZD8 gene CTD PMID:30720231 NCBI chr17:62,259,910...62,267,239
Ensembl chr17:62,262,129...62,265,113
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha decreases expression
multiple interactions
ISO Camptothecin results in decreased expression of GADD45A mRNA
Folic Acid inhibits the reaction [Camptothecin results in decreased expression of GADD45A mRNA]
CTD PMID:24792648, PMID:30581319 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression ISO Camptothecin results in increased expression of GADD45G mRNA CTD PMID:24792648 NCBI chr17:13,391,474...13,393,219
Ensembl chr17:13,391,467...13,393,243
JBrowse link
G Git2 GIT ArfGAP 2 decreases response to substance ISO GIT2 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr12:47,590,110...47,630,991
Ensembl chr12:47,590,154...47,631,119
JBrowse link
G Gpx4 glutathione peroxidase 4 decreases response to substance ISO GPX4 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression
decreases response to substance
ISO Camptothecin results in increased expression of GSTP1 protein
GSTP1 protein polymorphism results in decreased susceptibility to Camptothecin; GSTP1 protein results in decreased susceptibility to Camptothecin
CTD PMID:14732228, PMID:15500952 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases expression
increases phosphorylation
ISO
EXP
3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form]; [Aminacrine results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]; [MIR138-1 results in decreased expression of H2AX] which results in increased susceptibility to Camptothecin; [Propyl Gallate results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]]; Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form]; ERCC1 protein promotes the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]]; ERCC4 protein promotes the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]]; ESR1 promotes the reaction [Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form]]; H2AX gene mutant form inhibits the reaction [MIR138-1 results in increased susceptibility to Camptothecin]; palbociclib inhibits the reaction [Camptothecin results in increased expression of H2AX protein]; PPP2R2A protein inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form]; PPP2R5C protein promotes the reaction [Camptothecin results in increased expression of H2AX protein modified form]; PPP2R5E protein inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form]; TDP1 protein inhibits the reaction [Camptothecin results in increased expression of H2AX protein]; TDP1 protein inhibits the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]]; veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]
Camptothecin results in increased phosphorylation of H2AX protein
Camptothecin results in increased expression of H2AX protein; Camptothecin results in increased expression of H2AX protein modified form
CTD PMID:17875725, PMID:21227924, PMID:21646468, PMID:21693595, PMID:22302033, PMID:25269479, PMID:25772433, PMID:26928355, PMID:30720231, PMID:32482060 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression ISO Camptothecin results in decreased expression of HAMP mRNA CTD PMID:25633564 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Hemk1 HemK methyltransferase family member 1 decreases response to substance ISO HEMK1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 8:116,081,858...116,092,872
Ensembl chr 8:116,082,005...116,092,763
JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C multiple interactions ISO [HNRNPC protein binds to HNRNPC protein alternative form] which results in decreased susceptibility to Camptothecin CTD PMID:16960656 NCBI chr15:28,486,605...28,517,353
Ensembl chr15:28,486,617...28,517,353
JBrowse link
G Hoxa1 homeobox A1 decreases response to substance
multiple interactions
ISO HOXA1 mRNA results in decreased susceptibility to Camptothecin
Camptothecin inhibits the reaction [Vitamin A results in increased expression of HOXA1]
CTD PMID:25269479, PMID:26820057 NCBI chr 4:82,124,358...82,127,182
Ensembl chr 4:82,125,406...82,127,066
JBrowse link
G Ibsp integrin-binding sialoprotein decreases response to substance ISO IBSP mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr14:6,801,200...6,813,987
Ensembl chr14:6,801,204...6,813,945
JBrowse link
G Il1b interleukin 1 beta decreases response to substance ISO IL1B protein results in decreased susceptibility to Camptothecin CTD PMID:16356833 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Camptothecin results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
increases phosphorylation
ISO
EXP
Camptothecin results in increased expression of JUN protein
Glutathione inhibits the reaction [Camptothecin results in increased phosphorylation of JUN protein]; MAPK8 protein affects the reaction [Camptothecin results in increased phosphorylation of JUN protein]
CTD PMID:9751194, PMID:15585644, PMID:30266318, PMID:30885713 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 decreases response to substance ISO KCNK2 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr13:107,690,111...107,886,476
Ensembl chr13:107,690,087...107,886,476
JBrowse link
G Lgals1 galectin 1 decreases expression ISO Camptothecin results in decreased expression of LGALS1 mRNA; Camptothecin results in decreased expression of LGALS1 protein CTD PMID:19483324 NCBI chr 7:120,153,184...120,156,290
Ensembl chr 7:120,153,184...120,156,289
JBrowse link
G Lrch4 leucine rich repeats and calponin homology domain containing 4 decreases response to substance ISO LRCH4 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr12:22,127,387...22,138,436
Ensembl chr12:22,127,393...22,138,382
JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 multiple interactions
increases expression
ISO Camptothecin promotes the reaction [MAD2L1 protein binds to CDC20 protein]; CDKN1A protein affects the reaction [Camptothecin results in increased expression of MAD2L1 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of and results in increased activity of CDK1 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of CASP8 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of CASP9 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of CCNB1 protein]; MAPK8 protein affects the reaction [Camptothecin results in increased expression of MAD2L1 protein]
Camptothecin results in increased expression of MAD2L1 mRNA; Camptothecin results in increased expression of MAD2L1 protein
CTD PMID:30885713 NCBI chr 4:97,530,993...97,543,179
Ensembl chr 4:97,531,083...97,537,086
JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 increases expression ISO Camptothecin results in increased expression of MAP2K3 mRNA CTD PMID:17374387 NCBI chr10:45,089,455...45,110,802
Ensembl chr10:47,182,433...47,203,753
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 decreases expression ISO Camptothecin results in decreased expression of MAP3K5 mRNA CTD PMID:17374387 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 decreases response to substance ISO MAP3K7 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Camptothecin co-treated with Nicotine] results in increased phosphorylation of MAPK1 protein CTD PMID:24095863 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Camptothecin co-treated with Nicotine] results in increased phosphorylation of MAPK3 protein CTD PMID:24095863 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
ISO Camptothecin results in increased phosphorylation of MAPK8 protein
MAPK8 protein affects the reaction [Camptothecin results in increased activity of SP1 protein]; MAPK8 protein affects the reaction [Camptothecin results in increased expression of CCNB1 protein]; MAPK8 protein affects the reaction [Camptothecin results in increased expression of CDK1 protein]; MAPK8 protein affects the reaction [Camptothecin results in increased expression of MAD2L1 protein]; MAPK8 protein affects the reaction [Camptothecin results in increased phosphorylation of JUN protein]
CTD PMID:30885713, PMID:31255635 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO Camptothecin results in increased phosphorylation of MAPK9 protein CTD PMID:15585644 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO Camptothecin results in decreased expression of MAPT mRNA; Camptothecin results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mdc1 mediator of DNA damage checkpoint 1 multiple interactions ISO [Aminacrine results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]; [Propyl Gallate results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]; Aminacrine inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]; Camptothecin results in increased activity of and affects the localization of MDC1 protein; Propyl Gallate inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein] CTD PMID:26928355 NCBI chr20:3,405,017...3,419,831
Ensembl chr20:3,404,711...3,419,831
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO Camptothecin results in increased expression of MDM2 protein CTD PMID:17555331 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases expression ISO Camptothecin results in decreased expression of MGMT mRNA CTD PMID:18492797 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Mir138-1 microRNA 138-1 multiple interactions
increases response to substance
ISO [MIR138-1 results in decreased expression of H2AX] which results in increased susceptibility to Camptothecin; H2AX gene mutant form inhibits the reaction [MIR138-1 results in increased susceptibility to Camptothecin] CTD PMID:21693595 NCBI chr 8:131,731,726...131,731,824
Ensembl chr 8:131,731,726...131,731,824
JBrowse link
G Mir145 microRNA 145 increases expression
decreases expression
ISO Camptothecin results in increased expression of MIR145 mRNA
Camptothecin results in decreased expression of MIR145 mRNA
CTD PMID:24726431 NCBI chr18:56,969,907...56,969,994
Ensembl chr18:56,969,907...56,969,994
JBrowse link
G Mir34a microRNA 34a increases expression ISO Camptothecin results in increased expression of MIR34A mRNA CTD PMID:24726431 NCBI chr 5:167,092,491...167,092,592
Ensembl chr 5:167,092,491...167,092,592
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases response to substance
decreases methylation
ISO MMP9 mRNA results in decreased susceptibility to Camptothecin
Camptothecin results in decreased methylation of MMP9 gene
CTD PMID:25269479, PMID:30720231 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease decreases expression ISO Camptothecin results in decreased expression of MRE11 mRNA CTD PMID:24792648 NCBI chr 8:13,304,355...13,350,329
Ensembl chr 8:13,305,152...13,352,489
JBrowse link
G Mtmr2 myotubularin related protein 2 decreases response to substance ISO MTMR2 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 8:12,283,471...12,334,014
Ensembl chr 8:12,284,528...12,333,316
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression ISO Camptothecin results in decreased expression of MTOR protein CTD PMID:31255635 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
multiple interactions
affects localization
ISO Camptothecin results in increased expression of MYC mRNA
Camptothecin results in increased expression of and results in increased activity of MYC protein; MYC protein affects the reaction [Camptothecin results in increased expression of ATF4 protein]; MYC protein affects the reaction [Camptothecin results in increased expression of DDIT3 protein]; MYC protein affects the reaction [Camptothecin results in increased phosphorylation of EIF2AK3 protein]; MYC protein affects the reaction [Camptothecin results in increased phosphorylation of EIF2S1 protein]; TERT protein affects the reaction [Camptothecin results in increased expression of MYC protein]
Camptothecin affects the localization of MYC protein
CTD PMID:30266318, PMID:30851366 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Ncam1 neural cell adhesion molecule 1 decreases response to substance ISO NCAM1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 8:53,836,797...54,134,881
Ensembl chr 8:53,839,098...53,901,358
JBrowse link
G Nck2 NCK adaptor protein 2 decreases expression ISO Camptothecin results in decreased expression of NCK2 mRNA CTD PMID:17374387 NCBI chr 9:50,246,767...50,373,307
Ensembl chr 9:50,247,692...50,373,284
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Camptothecin inhibits the reaction [Rifampin promotes the reaction [NCOA1 protein binds to NR1I2 protein]] CTD PMID:29356861 NCBI chr 6:28,677,563...28,931,844
Ensembl chr 6:28,677,540...28,931,843
JBrowse link
G Ncor2 nuclear receptor co-repressor 2 multiple interactions ISO Camptothecin inhibits the reaction [NCOR2 protein binds to NR1I2 protein] CTD PMID:29356861 NCBI chr12:36,871,917...37,033,701
Ensembl chr12:36,871,999...37,033,701
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases activity
ISO NFE2L2 protein affects the reaction [Camptothecin results in increased expression of TERT mRNA]
Camptothecin results in increased activity of NFE2L2 protein
CTD PMID:30851366 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Camptothecin inhibits the reaction [NCOR2 protein binds to NR1I2 protein]; Camptothecin inhibits the reaction [Rifampin promotes the reaction [NCOA1 protein binds to NR1I2 protein]]; Camptothecin inhibits the reaction [Rifampin results in increased activity of NR1I2 protein] CTD PMID:29356861 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Olr1086 olfactory receptor 1086 decreases response to substance ISO OR7C2 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 7:13,698,647...13,699,609
Ensembl chr 7:13,698,647...13,699,609
JBrowse link
G Olr1514 olfactory receptor 1514 decreases response to substance ISO OR1A2 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr10:61,044,411...61,045,355
Ensembl chr10:61,044,411...61,045,355
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
affects response to substance
decreases response to substance
increases cleavage
ISO
EXP
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [Camptothecin results in increased cleavage of PARP1 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]; Camptothecin results in increased ADP-ribosylation of and results in increased degradation of PARP1 protein; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Camptothecin results in increased ADP-ribosylation of and results in increased degradation of PARP1 protein]; Nicotine inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]; PARP1 protein promotes the reaction [Camptothecin results in increased abundance of Poly Adenosine Diphosphate Ribose]; RBL2 protein inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]; THBS1 protein inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]
PARP1 protein affects the susceptibility to Camptothecin
PARP1 results in decreased susceptibility to Camptothecin
Tetrachlorodibenzodioxin promotes the reaction [Camptothecin results in increased cleavage of PARP1 protein]
[Camptothecin co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased cleavage of PARP1 protein; [veliparib results in decreased activity of PARP1 protein] which results in increased susceptibility to Camptothecin
CTD PMID:11741290, PMID:15585644, PMID:16962673, PMID:18506790, PMID:19559722, PMID:22158865, PMID:23376119, PMID:24095863, PMID:24726431, PMID:24792648, PMID:24823293, PMID:25412314, PMID:25449198, PMID:25843524, PMID:27694308, PMID:29384525, PMID:31255635 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Camptothecin binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Plk3 polo-like kinase 3 increases expression ISO Camptothecin results in increased expression of PLK3 mRNA CTD PMID:17374387 NCBI chr 5:135,997,725...136,002,900
Ensembl chr 5:135,997,725...136,002,900
JBrowse link
G Ppp1r16b protein phosphatase 1, regulatory subunit 16B decreases response to substance ISO PPP1R16B mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 3:155,160,474...155,267,002
Ensembl chr 3:155,160,481...155,262,941
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B decreases response to substance ISO PPP1R1B protein alternative form results in decreased susceptibility to Camptothecin; PPP1R1B protein results in decreased susceptibility to Camptothecin CTD PMID:16061638 NCBI chr10:86,303,727...86,312,770
Ensembl chr10:86,303,727...86,312,762
JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha multiple interactions ISO Camptothecin affects the localization of [PPP2R5E protein binds to PPP2CA protein] CTD PMID:25772433 NCBI chr10:37,534,449...37,554,861
Ensembl chr10:37,535,871...37,554,664
JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha affects localization
decreases response to substance
ISO Camptothecin affects the localization of PPP2R1A protein
PPP2R1A mRNA results in decreased susceptibility to Camptothecin
CTD PMID:25269479, PMID:25772433 NCBI chr 1:60,717,386...60,736,629
Ensembl chr 1:60,717,386...60,736,609
JBrowse link
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha multiple interactions
decreases response to substance
ISO PPP2R2A protein inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form]
PPP2R2A protein results in decreased susceptibility to Camptothecin
CTD PMID:25772433 NCBI chr15:43,673,958...43,733,182
Ensembl chr15:43,673,960...43,733,182
JBrowse link
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma multiple interactions
increases response to substance
ISO PPP2R5C protein promotes the reaction [Camptothecin results in increased expression of H2AX protein modified form]
PPP2R5C protein results in increased susceptibility to Camptothecin
CTD PMID:25772433 NCBI chr 6:134,804,128...134,941,912
Ensembl chr 6:134,804,141...134,939,358
JBrowse link
G Ppp2r5e protein phosphatase 2 regulatory subunit B', epsilon multiple interactions
decreases response to substance
ISO Camptothecin affects the localization of [PPP2R5E protein binds to PPP2CA protein]; PPP2R5E protein inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form]
PPP2R5E protein results in decreased susceptibility to Camptothecin
CTD PMID:25772433 NCBI chr 6:98,417,974...98,567,016
Ensembl chr 6:98,417,974...98,566,966
JBrowse link
G Prc1 protein regulator of cytokinesis 1 decreases expression ISO Camptothecin results in decreased expression of PRC1 mRNA CTD PMID:17374387 NCBI chr 1:142,087,181...142,108,746
Ensembl chr 1:142,087,208...142,108,746
JBrowse link
G Ptar1 protein prenyltransferase alpha subunit repeat containing 1 decreases response to substance ISO PTAR1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 1:241,501,679...241,557,651
Ensembl chr 1:241,501,679...241,557,651
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO Camptothecin results in decreased expression of and results in decreased phosphorylation of PTEN protein CTD PMID:30885713 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptpro protein tyrosine phosphatase, receptor type, O decreases response to substance ISO PTPRO mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 4:171,250,766...171,461,571
Ensembl chr 4:171,250,818...171,461,677
JBrowse link
G Rad50 RAD50 double strand break repair protein decreases expression ISO Camptothecin results in decreased expression of RAD50 mRNA CTD PMID:24792648 NCBI chr10:39,002,130...39,054,042
Ensembl chr10:39,001,498...39,054,142
JBrowse link
G Rad51 RAD51 recombinase decreases expression ISO Camptothecin results in decreased expression of RAD51 mRNA; Camptothecin results in decreased expression of RAD51 protein CTD PMID:10344722, PMID:24792648 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917
JBrowse link
G Rad51c RAD51 paralog C increases response to substance ISO RAD51C gene mutant form results in increased susceptibility to Camptothecin CTD PMID:20400963 NCBI chr10:74,697,713...74,724,004
Ensembl chr10:74,697,716...74,724,472
JBrowse link
G Rara retinoic acid receptor, alpha increases methylation ISO Camptothecin results in increased methylation of RARA gene CTD PMID:30720231 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rb1 RB transcriptional corepressor 1 increases phosphorylation
affects response to substance
ISO Camptothecin results in increased phosphorylation of RB1 protein
RB1 protein affects the susceptibility to Camptothecin
CTD PMID:14647467, PMID:14704340, PMID:15064736, PMID:15585644 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rbl1 RB transcriptional corepressor like 1 decreases expression ISO Camptothecin results in decreased expression of RBL1 protein CTD PMID:15585644 NCBI chr 3:153,263,692...153,321,351
Ensembl chr 3:153,263,692...153,321,352
JBrowse link
G Rbl2 RB transcriptional corepressor like 2 multiple interactions
decreases response to substance
ISO RBL2 protein inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]
RBL2 protein results in decreased susceptibility to Camptothecin
CTD PMID:15585644 NCBI chr19:17,300,088...17,346,865
Ensembl chr19:17,300,089...17,346,808
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases response to substance
multiple interactions
ISO
EXP
RELA results in increased susceptibility to Camptothecin
Camptothecin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] affects the localization of and results in increased phosphorylation of RELA protein]
Camptothecin inhibits the reaction [RELA protein binds to CREBBP protein]; pifithrin inhibits the reaction [Camptothecin inhibits the reaction [RELA protein binds to CREBBP protein]]
CTD PMID:13679428, PMID:21737676, PMID:25449198 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ret ret proto-oncogene decreases expression EXP Camptothecin results in decreased expression of RET protein CTD PMID:17555550 NCBI chr 4:150,202,170...150,249,196
Ensembl chr 4:150,202,058...150,244,372
JBrowse link
G Rnf31 ring finger protein 31 decreases response to substance ISO RNF31 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr15:34,270,037...34,282,385
Ensembl chr15:34,270,648...34,282,495
JBrowse link
G Rps6 ribosomal protein S6 increases expression ISO Camptothecin results in increased expression of RPS6 protein modified form CTD PMID:29384525 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 multiple interactions
increases expression
ISO 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Camptothecin results in increased expression of RRM2 protein]; 7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased expression of RRM2 mRNA]; 7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased expression of RRM2 protein]; Caffeine inhibits the reaction [Camptothecin results in increased expression of RRM2 mRNA]; Caffeine inhibits the reaction [Camptothecin results in increased expression of RRM2 protein]; E2F1 protein promotes the reaction [Camptothecin results in increased expression of RRM2 protein]
Camptothecin results in increased expression of RRM2 mRNA; Camptothecin results in increased expression of RRM2 protein
CTD PMID:22403396 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515
JBrowse link
G Sdc1 syndecan 1 increases expression ISO Camptothecin results in increased expression of SDC1 mRNA CTD PMID:17374387 NCBI chr 6:33,885,576...33,908,038
Ensembl chr 6:33,885,495...33,908,016
JBrowse link
G Sel1l SEL1L adaptor subunit of ERAD E3 ubiquitin ligase decreases response to substance ISO SEL1L mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 6:115,572,683...115,616,904
Ensembl chr 6:115,572,649...115,616,859
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression
ISO [SIRT1 mutant form co-treated with Camptothecin] results in increased acetylation of TP53 protein; Camptothecin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of SIRT1 protein]
Camptothecin results in decreased expression of SIRT1 protein
CTD PMID:24726431 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc2a12 solute carrier family 2 member 12 increases methylation ISO Camptothecin results in increased methylation of SLC2A12 gene CTD PMID:30720231 NCBI chr 1:24,003,625...24,056,373
Ensembl chr 1:24,003,625...24,056,373
JBrowse link
G Smn1 survival of motor neuron 1, telomeric multiple interactions
increases response to substance
ISO SMN1 mRNA affects the reaction [Camptothecin results in increased activity of CASP3 protein]
SMN1 protein results in increased susceptibility to Camptothecin
CTD PMID:15862279 NCBI chr 2:30,360,101...30,371,147
Ensembl chr 2:30,360,100...30,371,147
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 increases expression ISO Camptothecin results in increased expression of SMPD3 mRNA CTD PMID:19698806 NCBI chr19:38,237,963...38,321,572
Ensembl chr19:38,237,965...38,321,528
JBrowse link
G Sod1 superoxide dismutase 1 increases expression
multiple interactions
ISO Camptothecin results in increased expression of SOD1 protein
Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of SOD1 protein]
CTD PMID:30720231 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of SOD2 protein] CTD PMID:30720231 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sox11 SRY-box transcription factor 11 increases methylation ISO Camptothecin results in increased methylation of SOX11 gene CTD PMID:30720231 NCBI chr 6:46,629,967...46,631,988
Ensembl chr 6:46,629,974...46,631,983
JBrowse link
G Sox12 SRY-box transcription factor 12 increases methylation ISO Camptothecin results in increased methylation of SOX12 gene CTD PMID:30720231 NCBI chr 3:147,864,374...147,865,393
Ensembl chr 3:147,864,374...147,865,393
JBrowse link
G Sox17 SRY-box transcription factor 17 increases methylation ISO Camptothecin results in increased methylation of SOX17 gene CTD PMID:30720231 NCBI chr 5:14,890,318...14,895,907
Ensembl chr 5:14,890,408...14,895,907
JBrowse link
G Sox3 SRY-box transcription factor 3 increases methylation ISO Camptothecin results in increased methylation of SOX3 gene CTD PMID:30720231 NCBI chr  X:144,035,162...144,037,364
Ensembl chr  X:144,035,883...144,037,294
JBrowse link
G Sox4 SRY-box transcription factor 4 increases methylation ISO Camptothecin results in increased methylation of SOX4 gene CTD PMID:30720231 NCBI chr17:37,615,022...37,619,728 JBrowse link
G Sox8 SRY-box transcription factor 8 increases methylation ISO Camptothecin results in increased methylation of SOX8 gene CTD PMID:30720231 NCBI chr10:14,932,348...14,937,336
Ensembl chr10:14,932,348...14,937,336
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions
increases expression
increases activity
ISO Acetylcysteine inhibits the reaction [Camptothecin results in increased expression of SP1 mRNA]; Camptothecin results in increased activity of and affects the localization of SP1 protein; Camptothecin results in increased expression of and results in increased activity of SP1 protein; MAPK8 protein affects the reaction [Camptothecin results in increased activity of SP1 protein]; mithramycin A inhibits the reaction [Camptothecin results in increased activity of SP1 protein]; TERT protein affects the reaction [Camptothecin results in increased expression of SP1 protein] CTD PMID:11261509, PMID:30851366, PMID:30885713 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Sp3 Sp3 transcription factor increases activity
multiple interactions
ISO Camptothecin results in increased activity of SP3 protein
mithramycin A inhibits the reaction [Camptothecin results in increased activity of SP3 protein]
CTD PMID:11261509 NCBI chr 3:59,644,579...59,689,011
Ensembl chr 3:59,646,015...59,688,692
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases degradation
ISO ATG5 mutant form inhibits the reaction [Camptothecin results in increased degradation of SQSTM1 protein] CTD PMID:22927544 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Camptothecin results in increased expression of SRXN1 mRNA CTD PMID:22003191 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Stambpl1 STAM binding protein-like 1 increases methylation ISO Camptothecin results in increased methylation of STAMBPL1 gene CTD PMID:30720231 NCBI chr 1:252,490,125...252,536,113
Ensembl chr 1:252,497,452...252,536,104
JBrowse link
G Styxl1 serine/threonine/tyrosine interacting-like 1 decreases response to substance ISO STYXL1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr12:23,954,563...23,987,155
Ensembl chr12:23,954,574...23,987,271
JBrowse link
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 decreases response to substance ISO TAB2 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 1:1,999,574...2,017,574
Ensembl chr 1:1,999,596...2,073,896
JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member increases expression ISO Camptothecin results in increased expression of TAP1 mRNA CTD PMID:17374387 NCBI chr20:3,979,302...3,989,669
Ensembl chr20:3,979,035...3,989,669
JBrowse link
G Tax1bp3 Tax1 binding protein 3 increases expression ISO Camptothecin results in increased expression of TAX1BP3 mRNA CTD PMID:17374387 NCBI chr10:59,743,356...59,748,063
Ensembl chr10:59,743,544...59,748,062
JBrowse link
G Tdp1 tyrosyl-DNA phosphodiesterase 1 multiple interactions ISO TDP1 protein inhibits the reaction [Camptothecin results in increased expression of H2AX protein]; TDP1 protein inhibits the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]] CTD PMID:21227924 NCBI chr 6:123,895,860...123,963,688
Ensembl chr 6:123,897,956...123,963,675
JBrowse link
G Tert telomerase reverse transcriptase increases expression
multiple interactions
ISO Camptothecin results in increased expression of TERT mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Camptothecin results in increased phosphorylation of TERT protein]; Acetylcysteine inhibits the reaction [Camptothecin results in increased expression of TERT protein]; Camptothecin results in increased expression of and results in increased phosphorylation of TERT protein; Glutathione inhibits the reaction [Camptothecin results in increased expression of TERT protein]; NFE2L2 protein affects the reaction [Camptothecin results in increased expression of TERT mRNA]; TERT protein affects the reaction [Camptothecin results in increased expression of MYC protein]; TERT protein affects the reaction [Camptothecin results in increased expression of SP1 protein]; Wortmannin inhibits the reaction [Camptothecin results in increased phosphorylation of TERT protein]
CTD PMID:30851366 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
G Thbs1 thrombospondin 1 decreases expression
decreases secretion
multiple interactions
ISO Camptothecin results in decreased expression of THBS1 mRNA
Camptothecin results in decreased secretion of THBS1 protein
THBS1 protein inhibits the reaction [Camptothecin results in increased activity of CASP3 protein]; THBS1 protein inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]
CTD PMID:16962673 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Camptothecin binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Camptothecin binds to and results in decreased activity of THRB protein CTD PMID:25752796 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Tnfsf9 TNF superfamily member 9 increases expression ISO Camptothecin results in increased expression of TNFSF9 mRNA CTD PMID:17374387 NCBI chr 9:9,909,942...9,912,276
Ensembl chr 9:9,909,948...9,912,276
JBrowse link
G Top1 DNA topoisomerase I multiple interactions
decreases activity
decreases response to substance
ISO
EXP
[Ciprofloxacin co-treated with Camptothecin] results in decreased activity of TOP1 protein; [moxifloxacin co-treated with Camptothecin] results in decreased activity of TOP1 protein
Camptothecin results in decreased activity of TOP1 protein
Camptothecin analog results in decreased activity of TOP1 protein; Camptothecin results in decreased activity of TOP1 protein
TOP1 protein mutant form results in decreased susceptibility to Camptothecin
CTD PMID:12097280, PMID:18191106, PMID:20600288, PMID:21056033, PMID:21227924, PMID:23376119 NCBI chr 3:156,635,688...156,717,686
Ensembl chr 3:156,642,464...156,717,686
JBrowse link
G Tp53 tumor protein p53 multiple interactions
decreases response to substance
increases phosphorylation
affects response to substance
decreases acetylation
increases expression
increases response to substance
increases activity
increases glutathionylation
ISO
EXP
3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole promotes the reaction [Camptothecin results in increased expression of TP53 protein]; [SIRT1 mutant form co-treated with Camptothecin] results in increased acetylation of TP53 protein; Acetylcysteine inhibits the reaction [Camptothecin results in increased expression of TP53 protein modified form]; Camptothecin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased acetylation of TP53 protein]; Camptothecin results in increased stability of and results in increased expression of and results in increased phosphorylation of and results in increased activity of TP53 protein; nutlin 3 inhibits the reaction [Camptothecin results in increased expression of TP53 protein]; S-ethyl glutathione inhibits the reaction [Camptothecin results in increased expression of TP53 protein modified form]
TP53 mutant form results in decreased susceptibility to Camptothecin; TP53 protein mutant form results in decreased susceptibility to Camptothecin; TP53 protein results in decreased susceptibility to Camptothecin
Camptothecin results in increased phosphorylation of TP53 protein
TRP53 protein affects the susceptibility to Camptothecin
Camptothecin results in decreased acetylation of TP53 protein
TP53 protein results in increased susceptibility to Camptothecin
Camptothecin promotes the reaction [TP53 protein binds to CREBBP protein]; pifithrin inhibits the reaction [Camptothecin promotes the reaction [TP53 protein binds to CREBBP protein]]; pifithrin inhibits the reaction [Camptothecin results in increased activity of TP53 protein]
Camptothecin results in increased glutathionylation of TP53 protein
CTD PMID:9673414, PMID:10692111, PMID:11279278, PMID:11741290, PMID:12082016, PMID:13679428, PMID:17555331, PMID:19481069, PMID:20477944, PMID:20978201, PMID:23285096, PMID:24726431, PMID:25269479, PMID:26657896 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 increases expression ISO Camptothecin results in increased expression of TP53I3 mRNA CTD PMID:17374387 NCBI chr13:75,101,759...75,145,967
Ensembl chr13:75,105,615...75,143,441
JBrowse link
G Tp63 tumor protein p63 decreases expression ISO Camptothecin results in decreased expression of TP63 protein alternative form CTD PMID:23376119 NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501
JBrowse link
G Traf6 TNF receptor associated factor 6 decreases response to substance ISO TRAF6 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607
JBrowse link
G Trim28 tripartite motif-containing 28 increases expression ISO Camptothecin results in increased expression of TRIM28 protein modified form CTD PMID:25977998 NCBI chr 1:65,544,369...65,551,043
Ensembl chr 1:65,544,373...65,551,043
JBrowse link
G Tsg101 tumor susceptibility 101 decreases response to substance ISO TSG101 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 1:102,941,151...102,971,017
Ensembl chr 1:102,941,231...102,970,950
JBrowse link
G Twf1 twinfilin actin-binding protein 1 decreases response to substance ISO TWF1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 7:135,838,647...135,850,542
Ensembl chr 7:135,838,648...135,850,542
JBrowse link
G Tyms thymidylate synthetase increases expression ISO Camptothecin results in increased expression of TYMS mRNA CTD PMID:16568373 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 decreases methylation ISO Camptothecin results in decreased methylation of UGT1A6 gene CTD PMID:30720231 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Upf1 UPF1, RNA helicase and ATPase decreases response to substance ISO UPF1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr16:20,824,888...20,845,632
Ensembl chr16:20,824,864...20,845,243
JBrowse link
G Usp5 ubiquitin specific peptidase 5 decreases response to substance ISO USP5 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 4:157,332,735...157,347,803
Ensembl chr 4:157,332,740...157,347,803
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
decreases response to substance
ISO Camptothecin results in decreased expression of VEGFA protein
VEGFA protein results in decreased susceptibility to Camptothecin
CTD PMID:16356833, PMID:20116850 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions
decreases response to substance
ISO [Butyrates co-treated with Camptothecin] results in decreased expression of XIAP protein; [Camptothecin co-treated with FAS protein] results in decreased expression of XIAP protein
Camptothecin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of XIAP protein]
XIAP protein results in decreased susceptibility to Camptothecin
CTD PMID:16061681, PMID:16211302, PMID:19633536, PMID:25449198 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
G Xrcc3 X-ray repair cross complementing 3 decreases expression ISO Camptothecin results in decreased expression of XRCC3 mRNA CTD PMID:24792648 NCBI chr 6:136,366,917...136,380,751
Ensembl chr 6:136,371,555...136,379,348
JBrowse link
G Xrcc4 X-ray repair cross complementing 4 decreases response to substance
increases methylation
ISO XRCC4 results in decreased susceptibility to Camptothecin
Camptothecin results in increased methylation of XRCC4 gene
CTD PMID:21785230, PMID:30720231 NCBI chr 2:18,674,496...18,927,463
Ensembl chr 2:18,677,220...18,927,365
JBrowse link
G Zap70 zeta chain of T cell receptor associated protein kinase 70 decreases response to substance ISO ZAP70 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 9:43,331,149...43,353,097
Ensembl chr 9:43,331,155...43,353,113
JBrowse link
G Zc3hc1 zinc finger, C3HC-type containing 1 decreases response to substance ISO ZC3HC1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 4:57,684,678...57,706,613
Ensembl chr 4:57,684,678...57,706,613
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        aetiopathogenetic role 18951
          genotoxin 16984
            camptothecin 200
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      carboxylic ester 14367
                                        lactone 5988
                                          delta-lactone 3806
                                            camptothecin 200
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.