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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:3,4-dihydroxymandelic acid
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Accession:CHEBI:27637 term browser browse the term
Definition:A catechol that is the 3,4-dihydroxy derivative of mandelic acid; a metabolite of L-dopa.
Synonyms:related_synonym: (3,4-dihydroxyphenyl)(hydroxy)acetic acid;   2-(3,4-dihydroxyphenyl)-2-hydroxyacetic acid;   3,4-Dihydroxymandelate;   3,4-Dihydroxyphenylglycolic acid;   DOMA;   Dihydroxymandelic acid;   Formula=C8H8O5;   InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13);   InChIKey=RGHMISIYKIHAJW-UHFFFAOYSA-N;   SMILES=OC(C(O)=O)c1ccc(O)c(O)c1
 alt_id: CHEBI:1383;   CHEBI:19884
 xref: Beilstein:2104039;   CAS:775-01-9;   HMDB:HMDB0001866;   KEGG:C05580
 xref_mesh: MESH:C000989
 xref: PMID:12358456;   PMID:12649306;   PMID:17190852;   PMID:1736884;   PMID:1750693;   PMID:3104378;   PMID:5595114;   PMID:5778148;   PMID:5821523;   PMID:8193481;   Reaxys:2104039;   Wikipedia:3\,4-Dihydroxymandelic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:53326


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3,4-dihydroxymandelic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase increases methylation ISO COMT protein results in increased methylation of 3,4-dihydroxymandelic acid CTD PMID:11160877 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions EXP 3,4-dihydroxymandelic acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate] CTD PMID:10224140 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      chemical role 19422
        antioxidant 16120
          3,4-dihydroxymandelic acid 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  carbon oxoacid 18597
                                    carboxylic acid 18594
                                      hydroxy carboxylic acid 3857
                                        hydroxy monocarboxylic acid 3857
                                          2-hydroxy monocarboxylic acid 3127
                                            mandelic acid 6
                                              3,4-dihydroxymandelic acid 2
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