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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:psoralen
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Accession:CHEBI:27616 term browser browse the term
Definition:The simplest member of the class of psoralens that is 7H-furo[3,2-g]chromene having a keto group at position 7. It has been found in plants like Psoralea corylifolia and Ficus salicifolia.
Synonyms:exact_synonym: 7H-furo[3,2-g]chromen-7-one
 related_synonym: 3-(6-hydroxy-5-benzofuranyl)-2-propenoic acid delta-lactone;   6,7-furanocoumarin;   6-hydroxy-5-benzofuranacrylic acid delta-lactone;   7H-furo[3,2-g][1]benzopyran-7-one;   Ficusin;   Formula=C11H6O3;   InChI=1S/C11H6O3/c12-11-2-1-7-5-8-3-4-13-9(8)6-10(7)14-11/h1-6H;   InChIKey=ZCCUUQDIBDJBTK-UHFFFAOYSA-N;   Manaderm;   SMILES=O=c1ccc2cc3ccoc3cc2o1;   furo[2',3':7,6]coumarin;   furo[4',5':6,7]coumarin;   furocoumarin;   psoralene
 alt_id: CHEBI:26368;   CHEBI:378534;   CHEBI:8615
 xref: Beilstein:152784;   CAS:66-97-7;   KEGG:C09305;   KEGG:D08450;   KNApSAcK:C00000297
 xref_mesh: MESH:D005363
 xref: PMID:20196083;   PMID:21468912;   Reaxys:152784;   Wikipedia:Psoralen


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psoralen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression EXP Ficusin results in decreased expression of ABCB11 mRNA; Ficusin results in decreased expression of ABCB11 protein CTD PMID:30597224 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression EXP Ficusin results in decreased expression of ABCC2 mRNA; Ficusin results in decreased expression of ABCC2 protein CTD PMID:30597224 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Ficusin results in increased expression of ABCC3 mRNA; Ficusin results in increased expression of ABCC3 protein CTD PMID:30597224 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases expression ISO Ficusin results in increased expression of ABCC4 mRNA; Ficusin results in increased expression of ABCC4 protein CTD PMID:22173200 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Cat catalase multiple interactions EXP Ficusin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased activity of CAT protein] CTD PMID:27350165 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression ISO Ficusin results in decreased expression of CYP2E1 protein CTD PMID:22173200 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression EXP Ficusin results in decreased expression of CYP7A1 mRNA; Ficusin results in decreased expression of CYP7A1 protein CTD PMID:30597224 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases expression
EXP Ficusin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased activity of GPT protein]
Ficusin results in increased expression of GPT protein
CTD PMID:27350165, PMID:30597224 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases expression EXP Ficusin results in increased expression of NR1H4 mRNA; Ficusin results in increased expression of NR1H4 protein CTD PMID:30597224 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP Ficusin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of PPARG mRNA] CTD PMID:27350165 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Slc22a1 solute carrier family 22 member 1 increases expression
decreases expression
ISO Ficusin results in increased expression of SLC22A1 protein
Ficusin results in decreased expression of SLC22A1 mRNA
CTD PMID:22173200 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a12 solute carrier family 22 member 12 decreases expression ISO Ficusin results in decreased expression of SLC22A12 protein CTD PMID:22173200 NCBI chr 1:221,910,787...221,919,277
Ensembl chr 1:221,910,767...221,919,301
JBrowse link
G Slc22a2 solute carrier family 22 member 2 increases expression ISO Ficusin results in increased expression of SLC22A2 mRNA; Ficusin results in increased expression of SLC22A2 protein CTD PMID:22173200 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a4 solute carrier family 22 member 4 decreases expression ISO Ficusin results in decreased expression of SLC22A4 mRNA CTD PMID:22173200 NCBI chr10:39,334,972...39,373,508 JBrowse link
G Slc22a5 solute carrier family 22 member 5 increases expression ISO Ficusin results in increased expression of SLC22A5 protein CTD PMID:22173200 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853
JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases expression
increases expression
ISO Ficusin results in decreased expression of SLC22A8 mRNA
Ficusin results in increased expression of SLC22A8 protein
CTD PMID:22173200 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP Ficusin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of SLC2A4 mRNA] CTD PMID:27350165 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Slc2a9 solute carrier family 2 member 9 increases expression ISO Ficusin results in increased expression of SLC2A9 mRNA CTD PMID:22173200 NCBI chr14:77,067,537...77,192,702
Ensembl chr14:77,067,503...77,192,702
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 decreases expression EXP Ficusin results in decreased expression of SULT2A1 mRNA; Ficusin results in decreased expression of SULT2A1 protein CTD PMID:30597224 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
JBrowse link
5-methoxypsoralen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity
increases expression
multiple interactions
ISO 5-methoxypsoralen results in decreased activity of ABCB1 protein
5-methoxypsoralen results in increased expression of ABCB1 mRNA
[5-Methoxypsoralen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin; Verapamil inhibits the reaction [5-Methoxypsoralen results in decreased activity of ABCB1 protein]; Verapamil inhibits the reaction [[5-Methoxypsoralen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin]
CTD PMID:29079042 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO 5-methoxypsoralen results in increased expression of ABCC1 mRNA CTD PMID:29079042 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
decreases activity
decreases expression
ISO [5-methoxypsoralen results in decreased activity of ABCC2 protein] which results in decreased export of and results in increased abundance of Daunorubicin; Indomethacin inhibits the reaction [5-methoxypsoralen results in decreased activity of ABCC2 protein]; Indomethacin inhibits the reaction [[5-methoxypsoralen results in decreased activity of ABCC2 protein] which results in decreased export of and results in increased abundance of Daunorubicin]
5-methoxypsoralen results in decreased expression of ABCC2 mRNA
CTD PMID:29079042 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 decreases activity
multiple interactions
increases expression
ISO 5-methoxypsoralen results in decreased activity of ABCG2 protein
[5-methoxypsoralen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone; Novobiocin inhibits the reaction [5-methoxypsoralen results in decreased activity of ABCG2 protein]; Novobiocin inhibits the reaction [[5-methoxypsoralen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone]
5-methoxypsoralen results in increased expression of ABCG2 mRNA
CTD PMID:29079042 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO 5-Methoxypsoralen results in decreased phosphorylation of AKT1 protein
pifithrin inhibits the reaction [5-Methoxypsoralen results in decreased phosphorylation of AKT1 protein]
CTD PMID:30576070 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO 5-Methoxypsoralen results in increased expression of BAX protein CTD PMID:30576070 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions
increases expression
ISO pifithrin inhibits the reaction [5-Methoxypsoralen results in increased expression of BBC3 protein] CTD PMID:30576070 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [5-Methoxypsoralen results in increased expression of BMP2 mRNA]; SB 203580 inhibits the reaction [5-Methoxypsoralen results in increased expression of BMP2 mRNA]
5-methoxypsoralen results in increased expression of BMP2 mRNA
CTD PMID:17980360 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
ISO 5-Methoxypsoralen results in increased cleavage of CASP3 protein
pifithrin inhibits the reaction [5-Methoxypsoralen results in increased cleavage of CASP3 protein]
CTD PMID:30576070 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions
ISO 5-Methoxypsoralen results in increased cleavage of CASP9 protein
pifithrin inhibits the reaction [5-Methoxypsoralen results in increased cleavage of CASP9 protein]
CTD PMID:30576070 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO 5-Methoxypsoralen results in decreased expression of CCNE1 protein CTD PMID:30576070 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO 5-Methoxypsoralen results in decreased expression of CDK2 protein CTD PMID:30576070 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO 5-Methoxypsoralen results in increased expression of CDKN1A protein
pifithrin inhibits the reaction [5-Methoxypsoralen results in increased expression of CDKN1A protein]
CTD PMID:30576070 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO 5-methoxypsoralen results in increased phosphorylation of MAPK1 protein CTD PMID:17980360 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO 5-methoxypsoralen results in increased phosphorylation of MAPK3 protein CTD PMID:17980360 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions
increases expression
ISO pifithrin inhibits the reaction [5-Methoxypsoralen results in increased expression of PTEN protein] CTD PMID:30576070 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Smad1 SMAD family member 1 increases phosphorylation ISO 5-methoxypsoralen results in increased phosphorylation of SMAD1 protein CTD PMID:17980360 NCBI chr19:32,182,942...32,248,694
Ensembl chr19:32,188,267...32,248,684
JBrowse link
G Smad5 SMAD family member 5 increases phosphorylation ISO 5-methoxypsoralen results in increased phosphorylation of SMAD5 protein CTD PMID:17980360 NCBI chr17:8,307,448...8,336,996
Ensembl chr17:8,311,796...8,331,032
JBrowse link
G Smad9 SMAD family member 9 increases phosphorylation ISO 5-methoxypsoralen results in increased phosphorylation of SMAD9 protein CTD PMID:17980360 NCBI chr 2:143,951,725...144,002,025
Ensembl chr 2:144,191,846...144,212,138
Ensembl chr 2:144,191,846...144,212,138
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO 5-Methoxypsoralen results in increased expression of and results in increased phosphorylation of TP53 protein CTD PMID:30576070 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions EXP
ISO
5-methoxypsoralen promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin] CTD PMID:17599282 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
methoxsalen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression EXP Methoxsalen results in decreased expression of ABCB11 mRNA; Methoxsalen results in decreased expression of ABCB11 protein CTD PMID:28552422 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity
multiple interactions
increases expression
ISO Methoxsalen results in decreased activity of ABCB1 protein
[Methoxsalen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin; Verapamil inhibits the reaction [[Methoxsalen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin]; Verapamil inhibits the reaction [Methoxsalen results in decreased activity of ABCB1 protein]
Methoxsalen results in increased expression of ABCB1 mRNA
CTD PMID:29079042 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression ISO
EXP
Methoxsalen results in decreased expression of ABCB4 mRNA
Methoxsalen results in decreased expression of ABCB4 mRNA; Methoxsalen results in decreased expression of ABCB4 protein
CTD PMID:28552422 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO Methoxsalen results in increased expression of ABCC1 mRNA CTD PMID:29079042 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression
decreases activity
multiple interactions
ISO Methoxsalen results in decreased expression of ABCC2 mRNA
Methoxsalen results in decreased activity of ABCC2 protein
[Methoxsalen results in decreased activity of ABCC2 protein] which results in decreased export of and results in increased abundance of Daunorubicin; Indomethacin inhibits the reaction [[Methoxsalen results in decreased activity of ABCC2 protein] which results in decreased export of and results in increased abundance of Daunorubicin]; Indomethacin inhibits the reaction [Methoxsalen results in decreased activity of ABCC2 protein]
CTD PMID:29079042 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP
ISO
Methoxsalen results in increased expression of ABCC3 mRNA
Methoxsalen results in increased expression of ABCC3 protein
CTD PMID:28552422, PMID:30419252 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 affects expression
increases expression
ISO Methoxsalen affects the expression of ABCC4 protein
Methoxsalen results in increased expression of ABCC4 mRNA
CTD PMID:22173200 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases expression
decreases activity
ISO [Methoxsalen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone; Novobiocin inhibits the reaction [[Methoxsalen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone]; Novobiocin inhibits the reaction [Methoxsalen results in decreased activity of ABCG2 protein]
Methoxsalen results in increased expression of ABCG2 mRNA
CTD PMID:29079042 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Ahr aryl hydrocarbon receptor increases activity
multiple interactions
EXP
ISO
Methoxsalen results in increased activity of AHR protein
Methoxsalen inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]
CTD PMID:7702611, PMID:15670584 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of ATM protein modified form] CTD PMID:23907605 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Atr ATR serine/threonine kinase multiple interactions ISO Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of ATR protein modified form] CTD PMID:23907605 NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Methoxsalen results in increased expression of BAX protein CTD PMID:22796345 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO Methoxsalen inhibits the reaction [Aflatoxin B1 results in decreased expression of BCL2 protein]
Methoxsalen results in decreased expression of BCL2 protein
CTD PMID:22743290, PMID:22796345 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 multiple interactions
decreases expression
decreases response to substance
ISO BHLHE40 protein inhibits the reaction [Methoxsalen results in decreased expression of BIRC5 protein]; BHLHE40 protein inhibits the reaction [Methoxsalen results in increased activity of and results in decreased expression of CASP3 protein]
Methoxsalen results in decreased expression of BHLHE40 mRNA; Methoxsalen results in decreased expression of BHLHE40 protein
BHLHE40 protein results in decreased susceptibility to Methoxsalen
CTD PMID:22796345 NCBI chr 4:140,703,619...140,709,319
Ensembl chr 4:140,703,619...140,709,319
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression
ISO BHLHE40 protein inhibits the reaction [Methoxsalen results in decreased expression of BIRC5 protein] CTD PMID:22796345 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Brca1 BRCA1, DNA repair associated multiple interactions ISO Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of BRCA1 protein modified form] CTD PMID:23907605 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Casp3 caspase 3 multiple interactions ISO BHLHE40 protein inhibits the reaction [Methoxsalen results in increased activity of and results in decreased expression of CASP3 protein]; Methoxsalen inhibits the reaction [Aflatoxin B1 results in increased cleavage of CASP3 protein]; Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of CASP3 protein modified form]; Methoxsalen results in decreased expression of and results in increased activity of CASP3 protein CTD PMID:22743290, PMID:22796345, PMID:23907605 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 decreases expression ISO Methoxsalen results in decreased expression of CASP8 protein CTD PMID:22796345 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 decreases expression ISO Methoxsalen results in decreased expression of CASP9 protein CTD PMID:22796345 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO Methoxsalen inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CDKN1B protein] CTD PMID:15157999 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Ces2h carboxylesterase 2H multiple interactions
increases expression
ISO Dichlororibofuranosylbenzimidazole inhibits the reaction [Methoxsalen results in increased expression of CES2 mRNA]; NR1I2 protein promotes the reaction [Methoxsalen results in increased expression of CES2 mRNA]
Methoxsalen results in increased expression of CES2 mRNA; Methoxsalen results in increased expression of CES2 protein
CTD PMID:17003103 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of CHEK2 protein modified form] CTD PMID:23907605 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases expression
ISO
EXP
Methoxsalen inhibits the reaction [Carbaryl results in increased expression of CYP1A1 mRNA]
Methoxsalen results in decreased activity of CYP1A1 protein
Methoxsalen inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]; Methoxsalen inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; Methoxsalen inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Methoxsalen results in increased expression of CYP1A1 mRNA
Methoxsalen results in increased expression of and results in decreased activity of CYP1A1 protein
CTD PMID:7702611, PMID:9169082, PMID:15670584, PMID:18420780 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity EXP
ISO
Methoxsalen results in decreased activity of CYP1A2 protein CTD PMID:8819299, PMID:12814958, PMID:15879494, PMID:18420780 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Methoxsalen results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression EXP Methoxsalen results in decreased expression of CYP27A1 mRNA CTD PMID:28552422 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 decreases activity EXP Methoxsalen results in decreased activity of CYP2A1 protein CTD PMID:12814958 NCBI chr 1:83,711,223...83,725,222
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 decreases activity EXP Methoxsalen results in decreased activity of CYP2A3 protein CTD PMID:15879494 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity EXP
ISO
Methoxsalen results in decreased activity of CYP2B1 protein
Methoxsalen results in decreased activity of CYP2B10 protein
CTD PMID:15879494, PMID:18420780 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity EXP Methoxsalen results in decreased activity of CYP2C11 protein CTD PMID:12814958, PMID:15879494 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity EXP Methoxsalen results in decreased activity of CYP2C6V1 protein CTD PMID:12814958, PMID:15879494 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Methoxsalen results in decreased activity of CYP2C29 protein CTD PMID:18420780 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Methoxsalen results in decreased activity of CYP2D6 protein CTD PMID:18420780 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity EXP
ISO
Methoxsalen results in decreased activity of CYP2E1 protein CTD PMID:15879494, PMID:18420780 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity EXP Methoxsalen results in decreased activity of CYP3A2 protein CTD PMID:15879494 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 decreases activity EXP Methoxsalen results in decreased activity of CYP3A23-3A1 protein CTD PMID:15879494 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression
multiple interactions
increases expression
EXP
ISO
Methoxsalen results in decreased expression of CYP7A1 mRNA
Methoxsalen results in decreased expression of CYP7A1 protein
Methoxsalen affects the reaction [VDR protein affects the expression of CYP7A1 protein]
Methoxsalen results in increased expression of CYP7A1 protein
CTD PMID:28552422, PMID:30419252 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression EXP Methoxsalen results in decreased expression of CYP8B1 mRNA CTD PMID:28552422 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression EXP Methoxsalen results in increased expression of GPT protein CTD PMID:28552422 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of H2AX protein modified form] CTD PMID:23907605 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hal histidine ammonia lyase decreases activity ISO Methoxsalen results in decreased activity of HAL protein CTD PMID:20880231 NCBI chr 7:34,326,087...34,356,413
Ensembl chr 7:34,326,087...34,356,413
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression
multiple interactions
increases expression
EXP
ISO
Methoxsalen results in decreased expression of NR0B2 mRNA
VDR protein affects the reaction [Methoxsalen results in increased expression of NR0B2 protein]
CTD PMID:28552422, PMID:30419252 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression EXP Methoxsalen results in decreased expression of NR1H4 mRNA; Methoxsalen results in decreased expression of NR1H4 protein CTD PMID:28552422 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO
EXP
NR1I2 protein promotes the reaction [Methoxsalen results in increased expression of CES2 mRNA]; NR1I2 protein promotes the reaction [Methoxsalen results in increased expression of CYP3A4 mRNA]
Methoxsalen results in increased activity of NR1I2 protein
CTD PMID:17003103, PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Methoxsalen inhibits the reaction [Aflatoxin B1 results in increased expression of PARP1 protein modified form] CTD PMID:22743290 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression EXP Methoxsalen results in decreased expression of PPARA mRNA; Methoxsalen results in decreased expression of PPARA protein CTD PMID:28552422 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO Methoxsalen inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of RB1 protein] CTD PMID:15157999 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP Methoxsalen results in decreased expression of SLC10A1 mRNA; Methoxsalen results in decreased expression of SLC10A1 protein CTD PMID:28552422 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link
G Slc22a1 solute carrier family 22 member 1 increases expression ISO Methoxsalen results in increased expression of SLC22A1 protein CTD PMID:22173200 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases expression
increases expression
ISO Methoxsalen results in decreased expression of SLC22A2 mRNA
Methoxsalen results in increased expression of SLC22A2 protein
CTD PMID:22173200 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a5 solute carrier family 22 member 5 increases expression ISO Methoxsalen results in increased expression of SLC22A5 protein CTD PMID:22173200 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853
JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases expression ISO Methoxsalen results in decreased expression of SLC22A6 protein CTD PMID:22173200 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases expression ISO Methoxsalen results in increased expression of SLC22A8 protein CTD PMID:22173200 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Slc2a9 solute carrier family 2 member 9 decreases expression
increases expression
ISO Methoxsalen results in decreased expression of SLC2A9 protein
Methoxsalen results in increased expression of SLC2A9 mRNA
CTD PMID:22173200 NCBI chr14:77,067,537...77,192,702
Ensembl chr14:77,067,503...77,192,702
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO Methoxsalen analog results in decreased expression of TNF protein CTD PMID:15052360 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO Methoxsalen results in increased expression of TP53 protein
Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of TP53 protein modified form]
CTD PMID:22796345, PMID:23907605 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vdr vitamin D receptor multiple interactions
increases expression
ISO Methoxsalen affects the reaction [VDR protein affects the expression of CYP7A1 protein]; VDR protein affects the reaction [Methoxsalen results in increased expression of NR0B2 protein]
Methoxsalen results in increased expression of VDR protein
CTD PMID:30419252 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            eukaryotic metabolite 18906
              plant metabolite 17359
                psoralen 76
                  5-methoxy-8-(2'-hydroxy-3'-buthoxy-3'-methylbutyloxy)psoralen 0
                  5-methoxypsoralen 21
                  methoxsalen + 57
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  organic heteropolycyclic compound 17820
                                    organic heterotricyclic compound 14571
                                      furochromene 99
                                        furanocoumarin 99
                                          psoralens 90
                                            psoralen 76
                                              5-methoxy-8-(2'-hydroxy-3'-buthoxy-3'-methylbutyloxy)psoralen 0
                                              5-methoxypsoralen 21
                                              methoxsalen + 57
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.