|
G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
decreases expression |
EXP |
Ficusin results in decreased expression of ABCB11 mRNA; Ficusin results in decreased expression of ABCB11 protein |
CTD |
PMID:30597224 |
|
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
decreases expression |
EXP |
Ficusin results in decreased expression of ABCC2 mRNA; Ficusin results in decreased expression of ABCC2 protein |
CTD |
PMID:30597224 |
|
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
increases expression |
EXP |
Ficusin results in increased expression of ABCC3 mRNA; Ficusin results in increased expression of ABCC3 protein |
CTD |
PMID:30597224 |
|
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
increases expression |
ISO |
Ficusin results in increased expression of ABCC4 mRNA; Ficusin results in increased expression of ABCC4 protein |
CTD |
PMID:22173200 |
|
NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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G |
Abl1 |
ABL proto-oncogene 1, non-receptor tyrosine kinase |
affects binding |
ISO |
Ficusin binds to ABL1 protein |
CTD |
PMID:35597499 |
|
NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
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G |
Atf4 |
activating transcription factor 4 |
multiple interactions increases expression |
ISO |
4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of ATF4 mRNA] |
CTD |
PMID:31364909 |
|
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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|
G |
Atf6 |
activating transcription factor 6 |
increases expression multiple interactions |
ISO |
Ficusin results in increased expression of ATF6 mRNA; Ficusin results in increased expression of ATF6 protein 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of ATF6 mRNA]; 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of ATF6 protein] |
CTD |
PMID:31364909 |
|
NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
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|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression |
ISO |
4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of BAX protein] |
CTD |
PMID:31364909 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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|
G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
ISO |
Ficusin results in increased activity of CASP3 protein 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased activity of CASP3 protein] |
CTD |
PMID:31364909 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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|
G |
Casp8 |
caspase 8 |
multiple interactions increases activity |
ISO |
4-phenylbutyric acid inhibits the reaction [Ficusin results in increased activity of CASP8 protein] |
CTD |
PMID:31364909 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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|
G |
Cat |
catalase |
multiple interactions |
EXP |
Ficusin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased activity of CAT protein] |
CTD |
PMID:27350165 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
decreases expression |
ISO |
Ficusin results in decreased expression of CYP2E1 protein |
CTD |
PMID:22173200 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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|
G |
Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
decreases expression |
EXP |
Ficusin results in decreased expression of CYP7A1 mRNA; Ficusin results in decreased expression of CYP7A1 protein |
CTD |
PMID:30597224 |
|
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression multiple interactions |
ISO |
Ficusin results in increased expression of DDIT3 mRNA; Ficusin results in increased expression of DDIT3 protein 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of DDIT3 mRNA] |
CTD |
PMID:31364909 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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|
G |
Eif2a |
eukaryotic translation initiation factor 2A |
increases expression multiple interactions |
ISO |
Ficusin results in increased expression of EIF2A mRNA 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of EIF2A mRNA] |
CTD |
PMID:31364909 |
|
NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068
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|
G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions increases phosphorylation |
ISO |
4-phenylbutyric acid inhibits the reaction [Ficusin results in increased phosphorylation of EIF2AK3 protein] |
CTD |
PMID:31364909 |
|
NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions increases expression |
EXP |
Ficusin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased activity of GPT protein] Ficusin results in increased expression of GPT protein |
CTD |
PMID:27350165 PMID:30597224 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression multiple interactions |
ISO |
Ficusin results in increased expression of HSPA5 mRNA; Ficusin results in increased expression of HSPA5 protein 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of HSPA5 protein] |
CTD |
PMID:31364909 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Ins1 |
insulin 1 |
multiple interactions |
EXP |
Ficusin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of INS1 protein] |
CTD |
PMID:27350165 |
|
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
increases phosphorylation multiple interactions |
ISO |
Ficusin results in increased phosphorylation of MAPK8 protein 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:31364909 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mtor |
mechanistic target of rapamycin kinase |
decreases expression multiple interactions |
ISO |
Ficusin results in decreased expression of MTOR protein 5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-2,4-imidazolidinedione inhibits the reaction [Ficusin results in decreased expression of MTOR protein]; [Imatinib Mesylate co-treated with Ficusin] results in decreased expression of MTOR protein |
CTD |
PMID:35597499 |
|
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
decreases expression multiple interactions |
ISO |
Ficusin results in decreased expression of NFE2L2 protein 5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-2,4-imidazolidinedione inhibits the reaction [Ficusin results in decreased expression of NFE2L2 protein]; [Imatinib Mesylate co-treated with Ficusin] results in decreased expression of NFE2L2 protein |
CTD |
PMID:35597499 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nr1h4 |
nuclear receptor subfamily 1, group H, member 4 |
increases expression |
EXP |
Ficusin results in increased expression of NR1H4 mRNA; Ficusin results in increased expression of NR1H4 protein |
CTD |
PMID:30597224 |
|
NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
EXP |
Ficusin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of PPARG mRNA] |
CTD |
PMID:27350165 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Slc22a1 |
solute carrier family 22 member 1 |
increases expression decreases expression |
ISO |
Ficusin results in increased expression of SLC22A1 protein Ficusin results in decreased expression of SLC22A1 mRNA |
CTD |
PMID:22173200 |
|
NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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G |
Slc22a12 |
solute carrier family 22 member 12 |
decreases expression |
ISO |
Ficusin results in decreased expression of SLC22A12 protein |
CTD |
PMID:22173200 |
|
NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555
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G |
Slc22a2 |
solute carrier family 22 member 2 |
increases expression |
ISO |
Ficusin results in increased expression of SLC22A2 mRNA; Ficusin results in increased expression of SLC22A2 protein |
CTD |
PMID:22173200 |
|
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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G |
Slc22a4 |
solute carrier family 22 member 4 |
decreases expression |
ISO |
Ficusin results in decreased expression of SLC22A4 mRNA |
CTD |
PMID:22173200 |
|
NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720
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|
G |
Slc22a5 |
solute carrier family 22 member 5 |
increases expression |
ISO |
Ficusin results in increased expression of SLC22A5 protein |
CTD |
PMID:22173200 |
|
NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
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|
G |
Slc22a8 |
solute carrier family 22 member 8 |
decreases expression increases expression |
ISO |
Ficusin results in decreased expression of SLC22A8 mRNA Ficusin results in increased expression of SLC22A8 protein |
CTD |
PMID:22173200 |
|
NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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|
G |
Slc2a4 |
solute carrier family 2 member 4 |
multiple interactions |
EXP |
Ficusin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of SLC2A4 mRNA] |
CTD |
PMID:27350165 |
|
NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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|
G |
Slc2a9 |
solute carrier family 2 member 9 |
increases expression |
ISO |
Ficusin results in increased expression of SLC2A9 mRNA |
CTD |
PMID:22173200 |
|
NCBI chr14:72,328,334...72,461,981
Ensembl chr14:72,328,320...72,461,981
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|
G |
Sult2a1 |
sulfotransferase family 2A member 1 |
decreases expression |
EXP |
Ficusin results in decreased expression of SULT2A1 mRNA; Ficusin results in decreased expression of SULT2A1 protein |
CTD |
PMID:30597224 |
|
NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134
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|
G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
decreases activity increases expression multiple interactions |
ISO |
5-methoxypsoralen results in decreased activity of ABCB1 protein 5-methoxypsoralen results in increased expression of ABCB1 mRNA [5-Methoxypsoralen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin; Verapamil inhibits the reaction [5-Methoxypsoralen results in decreased activity of ABCB1 protein]; Verapamil inhibits the reaction [[5-Methoxypsoralen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin] |
CTD |
PMID:29079042 |
|
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
increases expression |
ISO |
5-methoxypsoralen results in increased expression of ABCC1 mRNA |
CTD |
PMID:29079042 |
|
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
|
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions decreases activity decreases expression |
ISO |
[5-methoxypsoralen results in decreased activity of ABCC2 protein] which results in decreased export of and results in increased abundance of Daunorubicin; Indomethacin inhibits the reaction [5-methoxypsoralen results in decreased activity of ABCC2 protein]; Indomethacin inhibits the reaction [[5-methoxypsoralen results in decreased activity of ABCC2 protein] which results in decreased export of and results in increased abundance of Daunorubicin] 5-methoxypsoralen results in decreased expression of ABCC2 mRNA |
CTD |
PMID:29079042 |
|
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
|
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
decreases activity multiple interactions increases expression |
ISO |
5-methoxypsoralen results in decreased activity of ABCG2 protein [5-methoxypsoralen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone; Novobiocin inhibits the reaction [5-methoxypsoralen results in decreased activity of ABCG2 protein]; Novobiocin inhibits the reaction [[5-methoxypsoralen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone] 5-methoxypsoralen results in increased expression of ABCG2 mRNA |
CTD |
PMID:29079042 |
|
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
|
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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation multiple interactions |
ISO EXP |
5-Methoxypsoralen results in decreased phosphorylation of AKT1 protein 5-Methoxypsoralen inhibits the reaction [Isoproterenol results in decreased phosphorylation of AKT1 protein] pifithrin inhibits the reaction [5-Methoxypsoralen results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:30576070 PMID:35815753 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
App |
amyloid beta precursor protein |
multiple interactions |
ISO |
5-Methoxypsoralen inhibits the reaction [Streptozocin results in increased expression of APP protein modified form] |
CTD |
PMID:34428446 |
|
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
5-Methoxypsoralen results in increased expression of BAX protein |
CTD |
PMID:30576070 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bbc3 |
Bcl-2 binding component 3 |
multiple interactions increases expression |
ISO |
pifithrin inhibits the reaction [5-Methoxypsoralen results in increased expression of BBC3 protein] |
CTD |
PMID:30576070 |
|
NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
|
|
G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions |
ISO |
5-Methoxypsoralen inhibits the reaction [Streptozocin results in decreased expression of BDNF protein] |
CTD |
PMID:34428446 |
|
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
|
|
G |
Becn1 |
beclin 1 |
multiple interactions |
ISO |
5-Methoxypsoralen inhibits the reaction [Streptozocin results in decreased expression of BECN1 protein modified form] |
CTD |
PMID:34428446 |
|
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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|
G |
Bmp2 |
bone morphogenetic protein 2 |
multiple interactions increases expression |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [5-Methoxypsoralen results in increased expression of BMP2 mRNA]; SB 203580 inhibits the reaction [5-Methoxypsoralen results in increased expression of BMP2 mRNA] 5-methoxypsoralen results in increased expression of BMP2 mRNA |
CTD |
PMID:17980360 |
|
NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
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|
G |
Casp3 |
caspase 3 |
increases cleavage multiple interactions |
ISO |
5-Methoxypsoralen results in increased cleavage of CASP3 protein pifithrin inhibits the reaction [5-Methoxypsoralen results in increased cleavage of CASP3 protein] |
CTD |
PMID:30576070 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp9 |
caspase 9 |
increases cleavage multiple interactions |
ISO |
5-Methoxypsoralen results in increased cleavage of CASP9 protein pifithrin inhibits the reaction [5-Methoxypsoralen results in increased cleavage of CASP9 protein] |
CTD |
PMID:30576070 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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|
G |
Cat |
catalase |
multiple interactions |
EXP |
5-Methoxypsoralen inhibits the reaction [Isoproterenol results in decreased activity of CAT protein] |
CTD |
PMID:35815753 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
|
|
G |
Ccnd1 |
cyclin D1 |
multiple interactions |
ISO |
5-Methoxypsoralen inhibits the reaction [Streptozocin results in decreased expression of CCND1 mRNA] |
CTD |
PMID:34428446 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
|
|
G |
Ccne1 |
cyclin E1 |
decreases expression |
ISO |
5-Methoxypsoralen results in decreased expression of CCNE1 protein |
CTD |
PMID:30576070 |
|
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
|
|
G |
Cdk2 |
cyclin dependent kinase 2 |
decreases expression |
ISO |
5-Methoxypsoralen results in decreased expression of CDK2 protein |
CTD |
PMID:30576070 |
|
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression multiple interactions |
ISO |
5-Methoxypsoralen results in increased expression of CDKN1A protein pifithrin inhibits the reaction [5-Methoxypsoralen results in increased expression of CDKN1A protein] |
CTD |
PMID:30576070 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
|
|
G |
Ctnnb1 |
catenin beta 1 |
multiple interactions |
ISO |
5-Methoxypsoralen inhibits the reaction [Streptozocin results in increased phosphorylation of CTNNB1 protein] |
CTD |
PMID:34428446 |
|
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
|
|
G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions |
ISO |
5-Methoxypsoralen inhibits the reaction [Streptozocin results in decreased phosphorylation of GSK3B protein] |
CTD |
PMID:34428446 |
|
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP |
5-Methoxypsoralen inhibits the reaction [Isoproterenol results in increased expression of IL1B protein] |
CTD |
PMID:35815753 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Il23a |
interleukin 23 subunit alpha |
multiple interactions |
ISO |
5-Methoxypsoralen inhibits the reaction [Streptozocin results in increased expression of IL23A protein] |
CTD |
PMID:34428446 |
|
NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
|
|
G |
Il27 |
interleukin 27 |
multiple interactions |
ISO |
5-Methoxypsoralen inhibits the reaction [Streptozocin results in increased expression of IL27 protein] |
CTD |
PMID:34428446 |
|
NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
5-Methoxypsoralen inhibits the reaction [Isoproterenol results in increased expression of IL6 protein] |
CTD |
PMID:35815753 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation |
ISO |
5-methoxypsoralen results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:17980360 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation |
ISO |
5-methoxypsoralen results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:17980360 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mapt |
microtubule-associated protein tau |
multiple interactions |
ISO |
5-Methoxypsoralen inhibits the reaction [Streptozocin results in increased expression of MAPT protein modified form] |
CTD |
PMID:34428446 |
|
NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
|
|
G |
Mtor |
mechanistic target of rapamycin kinase |
multiple interactions |
ISO |
5-Methoxypsoralen inhibits the reaction [Streptozocin results in increased expression of MTOR protein modified form] |
CTD |
PMID:34428446 |
|
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
|
|
G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions |
EXP |
5-Methoxypsoralen inhibits the reaction [Isoproterenol results in decreased phosphorylation of NOS3 protein] |
CTD |
PMID:35815753 |
|
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
|
|
G |
Ppp2ca |
protein phosphatase 2 catalytic subunit alpha |
multiple interactions |
ISO |
5-Methoxypsoralen inhibits the reaction [Streptozocin results in decreased expression of PPP2CA protein modified form] |
CTD |
PMID:34428446 |
|
NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862
|
|
G |
Prkg1 |
protein kinase cGMP-dependent 1 |
multiple interactions |
ISO |
5-Methoxypsoralen inhibits the reaction [Streptozocin results in decreased expression of PRKG1 protein] |
CTD |
PMID:34428446 |
|
NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080
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G |
Pten |
phosphatase and tensin homolog |
multiple interactions increases expression |
ISO |
pifithrin inhibits the reaction [5-Methoxypsoralen results in increased expression of PTEN protein] |
CTD |
PMID:30576070 |
|
NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
5-Methoxypsoralen inhibits the reaction [Streptozocin results in increased expression of RELA protein modified form] |
CTD |
PMID:34428446 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Smad1 |
SMAD family member 1 |
increases phosphorylation |
ISO |
5-methoxypsoralen results in increased phosphorylation of SMAD1 protein |
CTD |
PMID:17980360 |
|
NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651
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G |
Smad5 |
SMAD family member 5 |
increases phosphorylation |
ISO |
5-methoxypsoralen results in increased phosphorylation of SMAD5 protein |
CTD |
PMID:17980360 |
|
NCBI chr17:7,862,332...7,891,678
Ensembl chr17:7,864,720...7,891,634
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G |
Smad9 |
SMAD family member 9 |
increases phosphorylation |
ISO |
5-methoxypsoralen results in increased phosphorylation of SMAD9 protein |
CTD |
PMID:17980360 |
|
NCBI chr 2:138,956,326...139,006,315
Ensembl chr 2:138,986,471...139,006,307
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
5-Methoxypsoralen inhibits the reaction [Isoproterenol results in increased expression of TNF protein] |
CTD |
PMID:35815753 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnni3 |
troponin I3, cardiac type |
multiple interactions |
EXP |
5-Methoxypsoralen inhibits the reaction [Isoproterenol results in increased expression of TNNI3 protein] |
CTD |
PMID:35815753 |
|
NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
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G |
Tnnt2 |
troponin T2, cardiac type |
multiple interactions |
EXP |
5-Methoxypsoralen inhibits the reaction [Isoproterenol results in increased expression of TNNT2 protein] |
CTD |
PMID:35815753 |
|
NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388
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G |
Tp53 |
tumor protein p53 |
multiple interactions affects activity |
ISO |
5-Methoxypsoralen results in increased expression of and results in increased phosphorylation of TP53 protein 5-Methoxypsoralen metabolite affects the activity of TP53 protein |
CTD |
PMID:30576070 PMID:35435491 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
multiple interactions |
EXP ISO |
5-methoxypsoralen promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin] |
CTD |
PMID:17599282 |
|
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Wnt3a |
Wnt family member 3A |
multiple interactions |
ISO |
5-Methoxypsoralen inhibits the reaction [Streptozocin results in decreased expression of WNT3A protein] |
CTD |
PMID:34428446 |
|
NCBI chr10:44,034,174...44,078,366
Ensembl chr10:44,034,194...44,078,324
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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
decreases expression |
EXP |
Methoxsalen results in decreased expression of ABCB11 mRNA; Methoxsalen results in decreased expression of ABCB11 protein |
CTD |
PMID:28552422 |
|
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
decreases activity multiple interactions increases expression |
ISO |
Methoxsalen results in decreased activity of ABCB1 protein [Methoxsalen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin; Verapamil inhibits the reaction [[Methoxsalen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin]; Verapamil inhibits the reaction [Methoxsalen results in decreased activity of ABCB1 protein] Methoxsalen results in increased expression of ABCB1 mRNA |
CTD |
PMID:29079042 |
|
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcb4 |
ATP binding cassette subfamily B member 4 |
decreases expression |
ISO EXP |
Methoxsalen results in decreased expression of ABCB4 mRNA Methoxsalen results in decreased expression of ABCB4 mRNA; Methoxsalen results in decreased expression of ABCB4 protein |
CTD |
PMID:28552422 |
|
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
increases expression |
ISO |
Methoxsalen results in increased expression of ABCC1 mRNA |
CTD |
PMID:29079042 |
|
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
decreases expression decreases activity multiple interactions |
ISO |
Methoxsalen results in decreased expression of ABCC2 mRNA Methoxsalen results in decreased activity of ABCC2 protein [Methoxsalen results in decreased activity of ABCC2 protein] which results in decreased export of and results in increased abundance of Daunorubicin; Indomethacin inhibits the reaction [[Methoxsalen results in decreased activity of ABCC2 protein] which results in decreased export of and results in increased abundance of Daunorubicin]; Indomethacin inhibits the reaction [Methoxsalen results in decreased activity of ABCC2 protein] |
CTD |
PMID:29079042 |
|
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
increases expression |
EXP ISO |
Methoxsalen results in increased expression of ABCC3 mRNA Methoxsalen results in increased expression of ABCC3 protein |
CTD |
PMID:28552422 PMID:30419252 |
|
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
affects expression increases expression |
ISO |
Methoxsalen affects the expression of ABCC4 protein Methoxsalen results in increased expression of ABCC4 mRNA |
CTD |
PMID:22173200 |
|
NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
multiple interactions increases expression decreases activity |
ISO |
[Methoxsalen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone; Novobiocin inhibits the reaction [[Methoxsalen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone]; Novobiocin inhibits the reaction [Methoxsalen results in decreased activity of ABCG2 protein] Methoxsalen results in increased expression of ABCG2 mRNA |
CTD |
PMID:29079042 |
|
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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G |
Ahr |
aryl hydrocarbon receptor |
increases activity multiple interactions |
EXP ISO |
Methoxsalen results in increased activity of AHR protein Methoxsalen inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]] |
CTD |
PMID:7702611 PMID:15670584 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Atm |
ATM serine/threonine kinase |
multiple interactions |
ISO |
Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of ATM protein modified form] |
CTD |
PMID:23907605 |
|
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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G |
Atr |
ATR serine/threonine kinase |
multiple interactions |
ISO |
Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of ATR protein modified form] |
CTD |
PMID:23907605 |
|
NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
Methoxsalen results in increased expression of BAX protein |
CTD |
PMID:22796345 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression |
ISO |
Methoxsalen inhibits the reaction [Aflatoxin B1 results in decreased expression of BCL2 protein] Methoxsalen results in decreased expression of BCL2 protein |
CTD |
PMID:22743290 PMID:22796345 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bhlhe40 |
basic helix-loop-helix family, member e40 |
multiple interactions decreases expression decreases response to substance |
ISO |
BHLHE40 protein inhibits the reaction [Methoxsalen results in decreased expression of BIRC5 protein]; BHLHE40 protein inhibits the reaction [Methoxsalen results in increased activity of and results in decreased expression of CASP3 protein] Methoxsalen results in decreased expression of BHLHE40 mRNA; Methoxsalen results in decreased expression of BHLHE40 protein BHLHE40 protein results in decreased susceptibility to Methoxsalen |
CTD |
PMID:22796345 |
|
NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
multiple interactions decreases expression |
ISO |
BHLHE40 protein inhibits the reaction [Methoxsalen results in decreased expression of BIRC5 protein] |
CTD |
PMID:22796345 |
|
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Brca1 |
BRCA1, DNA repair associated |
multiple interactions |
ISO |
Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of BRCA1 protein modified form] |
CTD |
PMID:23907605 |
|
NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
BHLHE40 protein inhibits the reaction [Methoxsalen results in increased activity of and results in decreased expression of CASP3 protein]; Methoxsalen inhibits the reaction [Aflatoxin B1 results in increased cleavage of CASP3 protein]; Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of CASP3 protein modified form]; Methoxsalen results in decreased expression of and results in increased activity of CASP3 protein |
CTD |
PMID:22743290 PMID:22796345 PMID:23907605 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
decreases expression |
ISO |
Methoxsalen results in decreased expression of CASP8 protein |
CTD |
PMID:22796345 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
decreases expression |
ISO |
Methoxsalen results in decreased expression of CASP9 protein |
CTD |
PMID:22796345 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
multiple interactions |
ISO |
Methoxsalen inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CDKN1B protein] |
CTD |
PMID:15157999 |
|
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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G |
Ces2h |
carboxylesterase 2H |
multiple interactions increases expression |
ISO |
Dichlororibofuranosylbenzimidazole inhibits the reaction [Methoxsalen results in increased expression of CES2 mRNA]; NR1I2 protein promotes the reaction [Methoxsalen results in increased expression of CES2 mRNA] Methoxsalen results in increased expression of CES2 mRNA; Methoxsalen results in increased expression of CES2 protein |
CTD |
PMID:17003103 |
|
NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
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G |
Chek2 |
checkpoint kinase 2 |
multiple interactions |
ISO |
Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of CHEK2 protein modified form] |
CTD |
PMID:23907605 |
|
NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions decreases activity increases expression |
ISO EXP |
Methoxsalen inhibits the reaction [Carbaryl results in increased expression of CYP1A1 mRNA] Methoxsalen results in decreased activity of CYP1A1 protein Methoxsalen inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]; Methoxsalen inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; Methoxsalen inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] Methoxsalen results in increased expression of CYP1A1 mRNA Methoxsalen results in increased expression of and results in decreased activity of CYP1A1 protein |
CTD |
PMID:7702611 PMID:9169082 PMID:15670584 PMID:18420780 PMID:33814510 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity |
EXP ISO |
Methoxsalen results in decreased activity of CYP1A2 protein |
CTD |
PMID:8819299 PMID:12814958 PMID:15879494 PMID:18420780 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
decreases activity |
ISO |
Methoxsalen results in decreased activity of CYP1B1 protein |
CTD |
PMID:18420780 PMID:33814510 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp27a1 |
cytochrome P450, family 27, subfamily a, polypeptide 1 |
decreases expression |
EXP |
Methoxsalen results in decreased expression of CYP27A1 mRNA |
CTD |
PMID:28552422 |
|
NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
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G |
Cyp2a1 |
cytochrome P450, family 2, subfamily a, polypeptide 1 |
decreases activity multiple interactions |
EXP ISO |
Methoxsalen results in decreased activity of CYP2A1 protein [Methoxsalen results in decreased activity of CYP2A13 protein] which results in decreased susceptibility to Skatole; Methoxsalen inhibits the reaction [CYP2A13 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]; Methoxsalen inhibits the reaction [CYP2A13 protein results in increased metabolism of and results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]; Methoxsalen inhibits the reaction [CYP2A13 protein results in increased susceptibility to Aflatoxin B1] |
CTD |
PMID:12814958 PMID:17671098 PMID:18669584 PMID:20795680 PMID:22743290 |
|
NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
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G |
Cyp2a3 |
cytochrome P450, family 2, subfamily a, polypeptide 3 |
decreases activity |
EXP ISO |
Methoxsalen results in decreased activity of CYP2A3 protein Methoxsalen results in decreased activity of CYP2A4 protein |
CTD |
PMID:15879494 PMID:18420780 |
|
NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
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G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
decreases activity |
EXP |
Methoxsalen results in decreased activity of CYP2B1 protein |
CTD |
PMID:15879494 |
|
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
decreases activity |
ISO |
Methoxsalen results in decreased activity of CYP2B10 protein |
CTD |
PMID:18420780 |
|
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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G |
Cyp2c11 |
cytochrome P450, subfamily 2, polypeptide 11 |
decreases activity |
EXP ISO |
Methoxsalen results in decreased activity of CYP2C11 protein Methoxsalen results in decreased activity of CYP2C9 protein |
CTD |
PMID:12814958 PMID:15879494 PMID:18420780 |
|
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
decreases activity |
EXP ISO |
Methoxsalen results in decreased activity of CYP2C6V1 protein Methoxsalen results in decreased activity of CYP2C29 protein |
CTD |
PMID:12814958 PMID:15879494 PMID:18420780 |
|
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
decreases activity |
ISO |
Methoxsalen results in decreased activity of CYP2D6 protein |
CTD |
PMID:18420780 |
|
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
decreases activity |
EXP ISO |
Methoxsalen results in decreased activity of CYP2E1 protein |
CTD |
PMID:15879494 PMID:18420780 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
decreases activity increases expression multiple interactions |
EXP ISO |
Methoxsalen results in decreased activity of CYP3A2 protein Methoxsalen results in increased expression of CYP3A4 mRNA; Methoxsalen results in increased expression of CYP3A4 protein Methoxsalen results in decreased activity of CYP3A4 protein Dichlororibofuranosylbenzimidazole inhibits the reaction [Methoxsalen results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [Methoxsalen results in increased expression of CYP3A4 mRNA] |
CTD |
PMID:15879494 PMID:17003103 PMID:18420780 |
|
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
decreases activity |
EXP |
Methoxsalen results in decreased activity of CYP3A23-3A1 protein |
CTD |
PMID:15879494 |
|
NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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G |
Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
decreases expression multiple interactions increases expression |
EXP ISO |
Methoxsalen results in decreased expression of CYP7A1 mRNA Methoxsalen results in decreased expression of CYP7A1 protein Methoxsalen affects the reaction [VDR protein affects the expression of CYP7A1 protein] Methoxsalen results in increased expression of CYP7A1 protein |
CTD |
PMID:28552422 PMID:30419252 |
|
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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G |
Cyp8b1 |
cytochrome P450 family 8 subfamily B member 1 |
decreases expression |
EXP |
Methoxsalen results in decreased expression of CYP8B1 mRNA |
CTD |
PMID:28552422 |
|
NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
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G |
Gpt |
glutamic--pyruvic transaminase |
increases expression |
EXP |
Methoxsalen results in increased expression of GPT protein |
CTD |
PMID:28552422 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
H2ax |
H2A.X variant histone |
multiple interactions |
ISO |
Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of H2AX protein modified form] |
CTD |
PMID:23907605 |
|
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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G |
Hal |
histidine ammonia lyase |
decreases activity |
ISO |
Methoxsalen results in decreased activity of HAL protein |
CTD |
PMID:20880231 |
|
NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701
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G |
Nr0b2 |
nuclear receptor subfamily 0, group B, member 2 |
decreases expression multiple interactions increases expression |
EXP ISO |
Methoxsalen results in decreased expression of NR0B2 mRNA VDR protein affects the reaction [Methoxsalen results in increased expression of NR0B2 protein] |
CTD |
PMID:28552422 PMID:30419252 |
|
NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
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G |
Nr1h4 |
nuclear receptor subfamily 1, group H, member 4 |
decreases expression |
EXP |
Methoxsalen results in decreased expression of NR1H4 mRNA; Methoxsalen results in decreased expression of NR1H4 protein |
CTD |
PMID:28552422 |
|
NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions increases activity |
ISO EXP |
NR1I2 protein promotes the reaction [Methoxsalen results in increased expression of CES2 mRNA]; NR1I2 protein promotes the reaction [Methoxsalen results in increased expression of CYP3A4 mRNA] Methoxsalen results in increased activity of NR1I2 protein |
CTD |
PMID:17003103 PMID:25455453 |
|
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
Methoxsalen inhibits the reaction [Aflatoxin B1 results in increased expression of PARP1 protein modified form] |
CTD |
PMID:22743290 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
decreases expression |
EXP |
Methoxsalen results in decreased expression of PPARA mRNA; Methoxsalen results in decreased expression of PPARA protein |
CTD |
PMID:28552422 |
|
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Rb1 |
RB transcriptional corepressor 1 |
multiple interactions |
ISO |
Methoxsalen inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of RB1 protein] |
CTD |
PMID:15157999 |
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NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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G |
Slc10a1 |
solute carrier family 10 member 1 |
decreases expression |
EXP |
Methoxsalen results in decreased expression of SLC10A1 mRNA; Methoxsalen results in decreased expression of SLC10A1 protein |
CTD |
PMID:28552422 |
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NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
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G |
Slc22a1 |
solute carrier family 22 member 1 |
increases expression |
ISO |
Methoxsalen results in increased expression of SLC22A1 protein |
CTD |
PMID:22173200 |
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NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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G |
Slc22a2 |
solute carrier family 22 member 2 |
decreases expression increases expression |
ISO |
Methoxsalen results in decreased expression of SLC22A2 mRNA Methoxsalen results in increased expression of SLC22A2 protein |
CTD |
PMID:22173200 |
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NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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G |
Slc22a5 |
solute carrier family 22 member 5 |
increases expression |
ISO |
Methoxsalen results in increased expression of SLC22A5 protein |
CTD |
PMID:22173200 |
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NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
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G |
Slc22a6 |
solute carrier family 22 member 6 |
decreases expression |
ISO |
Methoxsalen results in decreased expression of SLC22A6 protein |
CTD |
PMID:22173200 |
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NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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G |
Slc22a8 |
solute carrier family 22 member 8 |
increases expression |
ISO |
Methoxsalen results in increased expression of SLC22A8 protein |
CTD |
PMID:22173200 |
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NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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G |
Slc2a9 |
solute carrier family 2 member 9 |
decreases expression increases expression |
ISO |
Methoxsalen results in decreased expression of SLC2A9 protein Methoxsalen results in increased expression of SLC2A9 mRNA |
CTD |
PMID:22173200 |
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NCBI chr14:72,328,334...72,461,981
Ensembl chr14:72,328,320...72,461,981
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G |
Tnf |
tumor necrosis factor |
decreases expression |
ISO |
Methoxsalen analog results in decreased expression of TNF protein |
CTD |
PMID:15052360 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
increases expression multiple interactions |
ISO |
Methoxsalen results in increased expression of TP53 protein Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of TP53 protein modified form] |
CTD |
PMID:22796345 PMID:23907605 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Vdr |
vitamin D receptor |
multiple interactions increases expression |
ISO |
Methoxsalen affects the reaction [VDR protein affects the expression of CYP7A1 protein]; VDR protein affects the reaction [Methoxsalen results in increased expression of NR0B2 protein] Methoxsalen results in increased expression of VDR protein |
CTD |
PMID:30419252 |
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NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
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