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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:thymol
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Accession:CHEBI:27607 term browser browse the term
Definition:A phenol that is a natural monoterpene derivative of cymene.
Synonyms:exact_synonym: 5-methyl-2-(propan-2-yl)phenol
 related_synonym: 1-hydroxy-5-methyl-2-isopropylbenzene;   2-isopropyl-5-methylphenol;   3-p-cymenol;   5-METHYL-2-(1-METHYLETHYL)PHENOL;   5-methyl-2-isopropylphenol;   6-isopropyl-3-methylphenol;   6-isopropyl-m-cresol;   Formula=C10H14O;   InChI=1S/C10H14O/c1-7(2)9-5-4-8(3)6-10(9)11/h4-7,11H,1-3H3;   InChIKey=MGSRCZKZVOBKFT-UHFFFAOYSA-N;   SMILES=CC(C)c1ccc(C)cc1O
 alt_id: CHEBI:27006;   CHEBI:43365;   CHEBI:9581
 xref: BPDB:1889;   CAS:89-83-8;   DrugBank:DB02513;   Drug_Central:4258;   KEGG:C09908;   KEGG:D01039;   KNApSAcK:C00000155;   LIPID_MAPS_instance:LMPR0102090029
 xref_mesh: MESH:D013943
 xref: PDBeChem:IPB;   VSDB:1889


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thymol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of ACP5 mRNA]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of ACP5 protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA] CTD PMID:30048646 NCBI chr 8:23,142,733...23,149,067
Ensembl chr 8:23,142,734...23,148,396
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity
ISO [4-cymene co-treated with gamma-terpinene co-treated with Thymol co-treated with carvacrol] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; [4-cymene co-treated with gamma-terpinene co-treated with Thymol co-treated with carvacrol] results in increased activity of AHR protein; [4-cymene co-treated with gamma-terpinene co-treated with Thymol] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; [4-cymene co-treated with gamma-terpinene co-treated with Thymol] results in increased activity of AHR protein; Thymol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
Thymol results in increased activity of AHR protein
CTD PMID:29191726 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization ISO Thymol affects the localization of AIFM1 protein CTD PMID:21640085 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Thymol results in increased expression of BAX protein CTD PMID:21640085 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Thymol results in decreased expression of BCL2 protein CTD PMID:21640085 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP Thymol inhibits the reaction [Isoproterenol results in decreased expression of BCL2L1 mRNA] CTD PMID:26996544 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA] CTD PMID:30048646 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Casp3 caspase 3 increases activity ISO Thymol results in increased activity of CASP3 protein CTD PMID:21640085 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
ISO
EXP
Thymol results in increased activity of CASP8 protein
Thymol inhibits the reaction [Isoproterenol results in increased expression of CASP8 mRNA]
CTD PMID:21640085, PMID:26996544 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO
EXP
Thymol results in increased activity of CASP9 protein
Thymol inhibits the reaction [Isoproterenol results in increased expression of CASP9 mRNA]
CTD PMID:21640085, PMID:26996544 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions EXP
ISO
Thymol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]
Thymol inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]
CTD PMID:26680107, PMID:26721194 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ctsk cathepsin K multiple interactions ISO Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of CTSK mRNA]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of CTSK protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK protein] CTD PMID:30048646 NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO Thymol results in increased expression of CYP1A1 mRNA
Thymol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CTD PMID:29191726 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Dcstamp dendrocyte expressed seven transmembrane protein multiple interactions ISO Thymol inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA] CTD PMID:30048646 NCBI chr 7:78,642,016...78,651,763
Ensembl chr 7:78,649,875...78,650,906
JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP Thymol inhibits the reaction [Isoproterenol results in increased expression of FAS mRNA] CTD PMID:26996544 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of FOS mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]; Thymol promotes the reaction [Lipopolysaccharides results in decreased expression of FOS protein] CTD PMID:30048646 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gab2 GRB2-associated binding protein 2 multiple interactions ISO Thymol inhibits the reaction [TNFSF11 protein results in increased expression of GAB2 mRNA] CTD PMID:30048646 NCBI chr 1:162,082,876...162,283,379
Ensembl chr 1:162,083,030...162,279,727
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions EXP Thymol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2] CTD PMID:11399263 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions EXP Thymol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2] CTD PMID:11399263 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions EXP Thymol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2] CTD PMID:11399263 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO Thymol inhibits the reaction [Dietary Fats results in decreased activity of GSR protein] CTD PMID:26680107 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A increases activity ISO Thymol results in increased activity of HTR3A protein CTD PMID:26456648 NCBI chr 8:53,211,436...53,223,878
Ensembl chr 8:53,211,438...53,223,804
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:30048646 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Mitf melanocyte inducing transcription factor multiple interactions ISO Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MITF mRNA] CTD PMID:30048646 NCBI chr 4:130,172,484...130,425,496
Ensembl chr 4:130,172,727...130,425,532
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 protein] CTD PMID:30048646 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MYC mRNA] CTD PMID:30048646 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of NFATC1 mRNA]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of NFATC1 protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein] CTD PMID:30048646 NCBI chr18:77,203,517...77,322,690
Ensembl chr18:77,203,525...77,322,690
JBrowse link
G Ogdh oxoglutarate dehydrogenase multiple interactions EXP Thymol inhibits the reaction [Isoproterenol results in decreased activity of OGDH protein] CTD PMID:26721194 NCBI chr14:86,414,924...86,481,903
Ensembl chr14:86,414,949...86,613,327
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO Thymol inhibits the reaction [TNFSF11 protein results in increased expression of SRC mRNA] CTD PMID:30048646 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Thymol inhibits the reaction [Dietary Fats results in increased expression of SREBF1 protein] CTD PMID:26680107 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Thymol inhibits the reaction [Dietary Fats results in increased expression of TGFB1 protein] CTD PMID:26680107 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:30048646 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A multiple interactions ISO Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF11A mRNA]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF11A protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA] CTD PMID:30048646 NCBI chr13:25,778,306...25,835,802
Ensembl chr13:25,778,317...25,835,957
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO Thymol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of GAB2 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MITF mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MYC mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of SRC mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA] CTD PMID:30048646 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 increases activity ISO Thymol results in increased activity of TRPV3 protein CTD PMID:16617338 NCBI chr10:59,829,755...59,863,780
Ensembl chr10:59,831,241...59,860,987
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Thymol CTD PMID:14557274 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of Thymol CTD PMID:14557274 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Thymol CTD PMID:14557274 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Thymol inhibits the reaction [Dietary Fats results in increased expression of VEGFA protein] CTD PMID:26680107 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
thymol sulfate(1-) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of ACP5 mRNA]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of ACP5 protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA] CTD PMID:30048646 NCBI chr 8:23,142,733...23,149,067
Ensembl chr 8:23,142,734...23,148,396
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity
ISO [4-cymene co-treated with gamma-terpinene co-treated with Thymol co-treated with carvacrol] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; [4-cymene co-treated with gamma-terpinene co-treated with Thymol co-treated with carvacrol] results in increased activity of AHR protein; [4-cymene co-treated with gamma-terpinene co-treated with Thymol] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; [4-cymene co-treated with gamma-terpinene co-treated with Thymol] results in increased activity of AHR protein; Thymol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
Thymol results in increased activity of AHR protein
CTD PMID:29191726 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization ISO Thymol affects the localization of AIFM1 protein CTD PMID:21640085 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Thymol results in increased expression of BAX protein CTD PMID:21640085 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Thymol results in decreased expression of BCL2 protein CTD PMID:21640085 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP Thymol inhibits the reaction [Isoproterenol results in decreased expression of BCL2L1 mRNA] CTD PMID:26996544 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA] CTD PMID:30048646 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Casp3 caspase 3 increases activity ISO Thymol results in increased activity of CASP3 protein CTD PMID:21640085 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
ISO
EXP
Thymol results in increased activity of CASP8 protein
Thymol inhibits the reaction [Isoproterenol results in increased expression of CASP8 mRNA]
CTD PMID:21640085, PMID:26996544 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
EXP
ISO
Thymol inhibits the reaction [Isoproterenol results in increased expression of CASP9 mRNA]
Thymol results in increased activity of CASP9 protein
CTD PMID:21640085, PMID:26996544 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions ISO
EXP
Thymol inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]
Thymol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]
CTD PMID:26680107, PMID:26721194 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ctsk cathepsin K multiple interactions ISO Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of CTSK mRNA]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of CTSK protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK protein] CTD PMID:30048646 NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO Thymol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Thymol results in increased expression of CYP1A1 mRNA
CTD PMID:29191726 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Dcstamp dendrocyte expressed seven transmembrane protein multiple interactions ISO Thymol inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA] CTD PMID:30048646 NCBI chr 7:78,642,016...78,651,763
Ensembl chr 7:78,649,875...78,650,906
JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP Thymol inhibits the reaction [Isoproterenol results in increased expression of FAS mRNA] CTD PMID:26996544 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of FOS mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]; Thymol promotes the reaction [Lipopolysaccharides results in decreased expression of FOS protein] CTD PMID:30048646 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gab2 GRB2-associated binding protein 2 multiple interactions ISO Thymol inhibits the reaction [TNFSF11 protein results in increased expression of GAB2 mRNA] CTD PMID:30048646 NCBI chr 1:162,082,876...162,283,379
Ensembl chr 1:162,083,030...162,279,727
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions EXP Thymol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2] CTD PMID:11399263 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions EXP Thymol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2] CTD PMID:11399263 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions EXP Thymol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2] CTD PMID:11399263 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO Thymol inhibits the reaction [Dietary Fats results in decreased activity of GSR protein] CTD PMID:26680107 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A increases activity ISO Thymol results in increased activity of HTR3A protein CTD PMID:26456648 NCBI chr 8:53,211,436...53,223,878
Ensembl chr 8:53,211,438...53,223,804
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:30048646 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Mitf melanocyte inducing transcription factor multiple interactions ISO Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MITF mRNA] CTD PMID:30048646 NCBI chr 4:130,172,484...130,425,496
Ensembl chr 4:130,172,727...130,425,532
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 protein] CTD PMID:30048646 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MYC mRNA] CTD PMID:30048646 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of NFATC1 mRNA]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of NFATC1 protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein] CTD PMID:30048646 NCBI chr18:77,203,517...77,322,690
Ensembl chr18:77,203,525...77,322,690
JBrowse link
G Ogdh oxoglutarate dehydrogenase multiple interactions EXP Thymol inhibits the reaction [Isoproterenol results in decreased activity of OGDH protein] CTD PMID:26721194 NCBI chr14:86,414,924...86,481,903
Ensembl chr14:86,414,949...86,613,327
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO Thymol inhibits the reaction [TNFSF11 protein results in increased expression of SRC mRNA] CTD PMID:30048646 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Thymol inhibits the reaction [Dietary Fats results in increased expression of SREBF1 protein] CTD PMID:26680107 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Thymol inhibits the reaction [Dietary Fats results in increased expression of TGFB1 protein] CTD PMID:26680107 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:30048646 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A multiple interactions ISO Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF11A mRNA]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF11A protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA] CTD PMID:30048646 NCBI chr13:25,778,306...25,835,802
Ensembl chr13:25,778,317...25,835,957
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO Thymol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of GAB2 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MITF mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MYC mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of SRC mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA] CTD PMID:30048646 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 increases activity ISO Thymol results in increased activity of TRPV3 protein CTD PMID:16617338 NCBI chr10:59,829,755...59,863,780
Ensembl chr10:59,831,241...59,860,987
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Thymol CTD PMID:14557274 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of Thymol CTD PMID:14557274 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Thymol CTD PMID:14557274 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Thymol inhibits the reaction [Dietary Fats results in increased expression of VEGFA protein] CTD PMID:26680107 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          volatile oil component 5977
            thymol 39
              thymol sulfate 0
              thymol sulfate(1-) 39
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                carbocyclic compound 18181
                                  benzenoid aromatic compound 17178
                                    benzenes 16920
                                      toluenes 6223
                                        p-cymene 57
                                          thymol 39
                                            thymol sulfate 0
                                            thymol sulfate(1-) 39
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.