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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:selenomethionine
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Accession:CHEBI:27585 term browser browse the term
Definition:A selenoamino acid that is the selenium analogue of methionine.
Synonyms:related_synonym: 2-amino-4-methylseleno-butanoic acid;   Formula=C5H11NO2Se;   InChI=1S/C5H11NO2Se/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8);   InChIKey=RJFAYQIBOAGBLC-UHFFFAOYSA-N;   SMILES=C[Se]CCC(N)C(O)=O;   Selenium methionine;   Seleno-DL-methionine
 alt_id: CHEBI:26638;   CHEBI:9098
 xref: CAS:1464-42-2;   HMDB:HMDB0003966
 xref_mesh: MESH:D012645
 xref: MetaCyc:SELENOMETHIONINE;   PMID:14969538;   PMID:20740325;   PMID:21259435;   PMID:21286848;   PMID:21366307;   PMID:21524942;   PMID:21603917;   PMID:21766323;   PMID:21870603;   PMID:21877325;   Reaxys:1758204;   Wikipedia:Selenomethionine


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selenomethionine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acd ACD, shelterin complex subunit and telomerase recruitment factor affects expression ISO Selenomethionine affects the expression of ACD mRNA CTD PMID:17222674 NCBI chr19:37,665,289...37,668,043
Ensembl chr19:37,665,296...37,667,987
JBrowse link
G Aco2 aconitase 2 affects expression ISO Selenomethionine affects the expression of ACO2 mRNA CTD PMID:17222674 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635
JBrowse link
G App amyloid beta precursor protein multiple interactions EXP Selenomethionine inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of GPX1 protein] CTD PMID:17280487 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Ar androgen receptor multiple interactions
decreases activity
ISO AR protein promotes the reaction [Selenomethionine results in decreased expression of KLK3 protein]; AR protein promotes the reaction [Selenomethionine results in increased expression of TP53 mRNA]
Selenomethionine results in decreased activity of AR protein
CTD PMID:16239064, PMID:17205524 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Atf2 activating transcription factor 2 affects expression ISO Selenomethionine affects the expression of ATF2 mRNA CTD PMID:17222674 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Atp6v0a1 ATPase H+ transporting V0 subunit a1 affects expression ISO Selenomethionine affects the expression of ATP6V0A1 mRNA CTD PMID:17222674 NCBI chr10:88,914,264...88,967,736
Ensembl chr10:88,914,276...88,967,748
JBrowse link
G Casp3 caspase 3 increases activity ISO Selenomethionine results in increased activity of CASP3 protein CTD PMID:21215776 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions ISO [SOD2 protein polymorphism affects the susceptibility to Selenomethionine analog] which affects the expression of CAT mRNA CTD PMID:28495429 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cbx6 chromobox 6 affects expression ISO Selenomethionine affects the expression of CBX6 mRNA CTD PMID:17222674 NCBI chr 7:121,047,996...121,058,109
Ensembl chr 7:121,050,302...121,058,029
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Selenomethionine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased activity of CDKN1A protein] CTD PMID:21515331 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cfl2 cofilin 2 affects expression ISO Selenomethionine affects the expression of CFL2 protein CTD PMID:18444160 NCBI chr 6:75,759,140...75,763,185
Ensembl chr 6:75,759,140...75,763,185
JBrowse link
G Clstn3 calsyntenin 3 affects expression ISO Selenomethionine affects the expression of CLSTN3 mRNA CTD PMID:17222674 NCBI chr 4:157,044,736...157,078,013
Ensembl chr 4:157,043,925...157,078,130
JBrowse link
G Cnnm3 cyclin and CBS domain divalent metal cation transport mediator 3 affects expression ISO Selenomethionine affects the expression of CNNM3 mRNA CTD PMID:17222674 NCBI chr 9:43,093,120...43,108,486
Ensembl chr 9:43,093,138...43,108,486
JBrowse link
G Col6a1 collagen type VI alpha 1 chain affects expression ISO Selenomethionine affects the expression of COL6A1 mRNA CTD PMID:17222674 NCBI chr20:12,657,913...12,676,370
Ensembl chr20:12,658,065...12,675,561
JBrowse link
G Crmp1 collapsin response mediator protein 1 affects expression ISO Selenomethionine affects the expression of CRMP1 mRNA CTD PMID:17222674 NCBI chr14:78,266,931...78,312,777
Ensembl chr14:78,266,931...78,308,933
JBrowse link
G Cyhr1 cysteine and histidine rich 1 affects expression ISO Selenomethionine affects the expression of CYHR1 mRNA CTD PMID:17222674 NCBI chr 7:117,720,909...117,722,734
Ensembl chr 7:117,706,727...117,722,723
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP Selenomethionine inhibits the reaction [T-2 Toxin results in increased expression of DDIT3 mRNA]; Selenomethionine inhibits the reaction [T-2 Toxin results in increased expression of DDIT3 protein] CTD PMID:29454614 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dst dystonin affects expression ISO Selenomethionine affects the expression of DST mRNA CTD PMID:17222674 NCBI chr 9:37,902,336...38,296,961
Ensembl chr 9:37,902,303...38,196,273
JBrowse link
G Dusp3 dual specificity phosphatase 3 affects expression ISO Selenomethionine affects the expression of DUSP3 mRNA CTD PMID:17222674 NCBI chr10:89,904,578...89,918,296
Ensembl chr10:89,904,560...89,918,427
JBrowse link
G Ece2 endothelin-converting enzyme 2 affects expression ISO Selenomethionine affects the expression of ECE2 mRNA CTD PMID:17222674 NCBI chr11:83,948,896...83,985,429
Ensembl chr11:83,948,230...83,964,055
JBrowse link
G Ecsit ECSIT signaling integrator affects expression ISO Selenomethionine affects the expression of ECSIT mRNA CTD PMID:17222674 NCBI chr 8:23,085,598...23,099,064
Ensembl chr 8:23,085,590...23,099,042
JBrowse link
G Egfr epidermal growth factor receptor increases expression ISO Selenomethionine results in increased expression of EGFR mRNA CTD PMID:17205524 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Ehd1 EH-domain containing 1 affects expression ISO Selenomethionine affects the expression of EHD1 mRNA CTD PMID:17222674 NCBI chr 1:221,644,867...221,667,242
Ensembl chr 1:221,644,867...221,667,239
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions EXP Selenomethionine inhibits the reaction [T-2 Toxin results in increased phosphorylation of EIF2S1 protein] CTD PMID:29454614 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Fam102a family with sequence similarity 102, member A affects expression ISO Selenomethionine affects the expression of FAM102A mRNA CTD PMID:17222674 NCBI chr 3:11,554,084...11,586,315
Ensembl chr 3:11,554,457...11,586,303
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Selenomethionine inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of FOS protein]; Selenomethionine inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of FOS protein] CTD PMID:14572605 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fus FUS RNA binding protein affects localization
multiple interactions
ISO Selenomethionine affects the localization of FUS protein
Selenomethionine promotes the reaction [TUBA4A protein binds to FUS protein]
CTD PMID:31585128 NCBI chr 1:199,412,805...199,426,705
Ensembl chr 1:199,412,834...199,426,702
JBrowse link
G Gck glucokinase increases expression ISO Selenomethionine results in increased expression of GCK mRNA CTD PMID:28810182 NCBI chr14:86,149,146...86,191,589
Ensembl chr14:86,148,928...86,190,659
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Selenomethionine results in increased expression of GCLC mRNA CTD PMID:22807314 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gpx1 glutathione peroxidase 1 affects expression
increases expression
multiple interactions
increases activity
ISO
EXP
Selenomethionine affects the expression of GPX1 mRNA
Selenomethionine results in increased expression of GPX1 mRNA
[SOD2 protein polymorphism affects the susceptibility to Selenomethionine analog] which affects the expression of GPX1 mRNA
Selenomethionine results in increased activity of GPX1 protein
Selenomethionine inhibits the reaction [Diethylhexyl Phthalate results in decreased activity of GPX1 protein]; Selenomethionine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased activity of GPX1 protein]
Selenomethionine inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of GPX1 protein]
Selenomethionine results in increased expression of GPX1 mRNA; Selenomethionine results in increased expression of GPX1 protein
CTD PMID:16632112, PMID:17222674, PMID:17280487, PMID:20659492, PMID:28495429, PMID:29454614, PMID:31585128 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Grk6 G protein-coupled receptor kinase 6 affects expression ISO Selenomethionine affects the expression of GRK6 mRNA CTD PMID:17222674 NCBI chr17:9,705,917...9,721,921
Ensembl chr17:9,703,453...9,721,574
JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO Selenomethionine results in increased expression of GSR protein CTD PMID:21215776 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases methylation
increases expression
ISO Selenomethionine results in decreased methylation of GSTP1 promoter
Selenomethionine results in increased expression of GSTP1 mRNA; Selenomethionine results in increased expression of GSTP1 protein
CTD PMID:18676679 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hpn hepsin affects expression ISO Selenomethionine affects the expression of HPN mRNA CTD PMID:17222674 NCBI chr 1:89,534,112...89,549,575
Ensembl chr 1:89,534,106...89,543,967
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions ISO Selenomethionine inhibits the reaction [Mercuric Chloride results in increased expression of HSPA1A mRNA] CTD PMID:16324719 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Selenomethionine inhibits the reaction [T-2 Toxin results in increased expression of HSPA5 mRNA]; Selenomethionine inhibits the reaction [T-2 Toxin results in increased expression of HSPA5 protein] CTD PMID:29454614 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 affects expression ISO Selenomethionine affects the expression of HSPE1 protein CTD PMID:18444160 NCBI chr 9:61,691,246...61,724,948
Ensembl chr 9:61,692,154...61,694,599
JBrowse link
G Ifng interferon gamma multiple interactions
decreases secretion
ISO Selenomethionine inhibits the reaction [sodium arsenite results in decreased secretion of IFNG protein]
Selenomethionine results in decreased secretion of IFNG protein
CTD PMID:24218229 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta affects expression ISO Selenomethionine affects the expression of IKBKB mRNA CTD PMID:17222674 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il4 interleukin 4 multiple interactions
decreases secretion
ISO Selenomethionine inhibits the reaction [sodium arsenite results in decreased secretion of IL4 protein]
Selenomethionine results in decreased secretion of IL4 protein
CTD PMID:24218229 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Itm2c integral membrane protein 2C affects expression ISO Selenomethionine affects the expression of ITM2C mRNA CTD PMID:17222674 NCBI chr 9:92,916,469...92,930,306
Ensembl chr 9:92,916,469...92,930,279
JBrowse link
G Klhdc3 kelch domain containing 3 affects expression ISO Selenomethionine affects the expression of KLHDC3 mRNA CTD PMID:17222674 NCBI chr 9:16,612,429...16,618,761
Ensembl chr 9:16,612,433...16,618,761
JBrowse link
G L3mbtl4 L3MBTL histone methyl-lysine binding protein 4 affects expression ISO Selenomethionine affects the expression of L3MBTL4 mRNA CTD PMID:17222674 NCBI chr 9:116,521,937...116,689,388 JBrowse link
G Lasp1 LIM and SH3 protein 1 affects expression ISO Selenomethionine affects the expression of LASP1 mRNA CTD PMID:17222674 NCBI chr10:85,744,662...85,785,130
Ensembl chr10:85,744,568...85,785,133
JBrowse link
G Ltbr lymphotoxin beta receptor affects expression ISO Selenomethionine affects the expression of LTBR mRNA CTD PMID:17222674 NCBI chr 4:157,822,838...157,829,291
Ensembl chr 4:157,822,840...157,829,241
JBrowse link
G Map3k11 mitogen-activated protein kinase kinase kinase 11 affects expression ISO Selenomethionine affects the expression of MAP3K11 mRNA CTD PMID:17222674 NCBI chr 1:221,043,119...221,056,420
Ensembl chr 1:221,043,119...221,056,417
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO Selenomethionine results in decreased phosphorylation of MAPK1 protein CTD PMID:21215776 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO Selenomethionine results in decreased phosphorylation of MAPK3 protein CTD PMID:21215776 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Selenomethionine inhibits the reaction [Spermine results in increased activity of MAPK8 protein] CTD PMID:20121705 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mrpl54 mitochondrial ribosomal protein L54 affects expression ISO Selenomethionine affects the expression of MRPL54 mRNA CTD PMID:17222674 NCBI chr 7:11,321,057...11,323,577
Ensembl chr 7:11,321,057...11,323,577
JBrowse link
G Narf nuclear prelamin A recognition factor affects expression ISO Selenomethionine affects the expression of NARF mRNA CTD PMID:17222674 NCBI chr10:110,445,765...110,463,735
Ensembl chr10:110,445,797...110,463,727
JBrowse link
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 affects expression ISO Selenomethionine affects the expression of NDUFV1 mRNA CTD PMID:17222674 NCBI chr 1:219,254,293...219,259,328
Ensembl chr 1:219,254,279...219,259,448
JBrowse link
G Nme6 NME/NM23 nucleoside diphosphate kinase 6 affects expression ISO Selenomethionine affects the expression of NME6 protein CTD PMID:18444160 NCBI chr 8:117,920,912...117,928,148
Ensembl chr 8:117,920,944...117,928,195
JBrowse link
G Nos1 nitric oxide synthase 1 increases expression ISO Selenomethionine results in increased expression of NOS1 protein CTD PMID:21215776 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Selenomethionine inhibits the reaction [Spermine results in increased activity of NOS2 protein] CTD PMID:20121705 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Selenomethionine results in increased expression of NQO1 mRNA; Selenomethionine results in increased expression of NQO1 protein CTD PMID:22807314 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Parvb parvin, beta affects expression ISO Selenomethionine affects the expression of PARVB mRNA CTD PMID:17222674 NCBI chr 7:125,189,827...125,275,977
Ensembl chr 7:125,189,827...125,277,689
JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) affects expression ISO Selenomethionine affects the expression of PCK2 mRNA CTD PMID:17222674 NCBI chr15:34,216,735...34,224,357
Ensembl chr15:34,216,833...34,224,193
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO Selenomethionine results in decreased expression of PCNA protein CTD PMID:17431106 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pcnx3 pecanex 3 affects expression ISO Selenomethionine affects the expression of PCNX3 mRNA CTD PMID:17222674 NCBI chr 1:221,019,091...221,041,959
Ensembl chr 1:221,019,500...221,041,401
JBrowse link
G Pigu phosphatidylinositol glycan anchor biosynthesis, class U affects expression ISO Selenomethionine affects the expression of PIGU mRNA CTD PMID:17222674 NCBI chr 3:150,803,096...150,885,597
Ensembl chr 3:150,803,097...150,885,616
JBrowse link
G Plg plasminogen affects expression ISO Selenomethionine affects the expression of PLG mRNA CTD PMID:17222674 NCBI chr 1:48,521,828...48,563,895
Ensembl chr 1:48,521,772...48,563,776
JBrowse link
G Pmvk phosphomevalonate kinase affects expression ISO Selenomethionine affects the expression of PMVK mRNA CTD PMID:17222674 NCBI chr 2:188,784,329...188,793,890
Ensembl chr 2:188,784,222...188,793,895
JBrowse link
G Poll DNA polymerase lambda affects expression ISO Selenomethionine affects the expression of POLL mRNA CTD PMID:17222674 NCBI chr 1:265,290,337...265,298,847
Ensembl chr 1:265,290,339...265,298,797
JBrowse link
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B affects expression ISO Selenomethionine affects the expression of PPM1B mRNA CTD PMID:17222674 NCBI chr 6:8,219,385...8,280,127
Ensembl chr 6:8,218,696...8,280,124
JBrowse link
G Prkcz protein kinase C, zeta affects expression ISO Selenomethionine affects the expression of PRKCZ mRNA CTD PMID:17222674 NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421
JBrowse link
G Rap2a RAP2A, member of RAS oncogene family affects expression ISO Selenomethionine affects the expression of RAP2A mRNA CTD PMID:17222674 NCBI chr15:105,851,543...105,852,033
Ensembl chr15:105,851,542...105,878,666
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation
ISO Selenomethionine inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of RELA protein]; Selenomethionine inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of RELA protein]
Selenomethionine results in increased phosphorylation of RELA protein
CTD PMID:14572605, PMID:21215776 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rpusd1 RNA pseudouridine synthase domain containing 1 affects expression ISO Selenomethionine affects the expression of RPUSD1 mRNA CTD PMID:17222674 NCBI chr10:15,099,104...15,102,968
Ensembl chr10:15,099,009...15,102,960
JBrowse link
G Scarb1 scavenger receptor class B, member 1 affects expression ISO Selenomethionine affects the expression of SCARB1 mRNA CTD PMID:17222674 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
JBrowse link
G Selenoh selenoprotein H increases expression ISO Selenomethionine results in increased expression of SELENOH mRNA CTD PMID:28810182 NCBI chr 3:72,070,342...72,071,909
Ensembl chr 3:72,070,390...72,071,895
JBrowse link
G Sema5a semaphorin 5A affects expression ISO Selenomethionine affects the expression of SEMA5A mRNA CTD PMID:17222674 NCBI chr 2:85,377,318...85,808,970
Ensembl chr 2:85,377,318...85,808,970
JBrowse link
G Shc1 SHC adaptor protein 1 affects expression ISO Selenomethionine affects the expression of SHC1 mRNA CTD PMID:17222674 NCBI chr 2:188,745,503...188,757,066
Ensembl chr 2:188,745,503...188,757,066
JBrowse link
G Slc25a1 solute carrier family 25 member 1 affects expression ISO Selenomethionine affects the expression of SLC25A1 mRNA CTD PMID:17222674 NCBI chr11:87,204,248...87,207,265
Ensembl chr11:87,204,175...87,207,264
JBrowse link
G Slc3a1 solute carrier family 3 member 1 increases uptake ISO SLC3A1 protein results in increased uptake of Selenomethionine CTD PMID:18845132 NCBI chr 6:8,284,937...8,318,649
Ensembl chr 6:8,284,878...8,318,674
JBrowse link
G Slc6a19 solute carrier family 6 member 19 increases uptake ISO SLC6A19 protein results in increased uptake of Selenomethionine CTD PMID:18845132 NCBI chr 1:32,199,869...32,218,628
Ensembl chr 1:32,199,810...32,220,045
JBrowse link
G Sod1 superoxide dismutase 1 affects localization
decreases expression
multiple interactions
ISO Selenomethionine affects the localization of SOD1 protein
Selenomethionine results in decreased expression of SOD1 protein
[SOD2 protein polymorphism affects the susceptibility to Selenomethionine analog] which affects the expression of SOD1 mRNA
CTD PMID:21215776, PMID:28495429, PMID:31585128 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 increases expression
affects response to substance
multiple interactions
ISO Selenomethionine results in increased expression of SOD2 protein
SOD2 protein polymorphism affects the susceptibility to Selenomethionine analog
[SOD2 protein polymorphism affects the susceptibility to Selenomethionine analog] which affects the expression of CAT mRNA; [SOD2 protein polymorphism affects the susceptibility to Selenomethionine analog] which affects the expression of GPX1 mRNA; [SOD2 protein polymorphism affects the susceptibility to Selenomethionine analog] which affects the expression of SOD1 mRNA; [SOD2 protein polymorphism affects the susceptibility to Selenomethionine analog] which affects the expression of SOD2 mRNA
CTD PMID:21215776, PMID:28495429 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression
decreases methylation
ISO Selenomethionine results in increased expression of SREBF1 mRNA
Selenomethionine results in decreased methylation of SREBF1 exon
CTD PMID:28810182 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Srrt serrate, RNA effector molecule affects expression ISO Selenomethionine affects the expression of SRRT mRNA CTD PMID:17222674 NCBI chr12:22,457,898...22,471,090 JBrowse link
G Ssbp1 single stranded DNA binding protein 1 affects expression ISO Selenomethionine affects the expression of SSBP1 protein CTD PMID:18444160 NCBI chr 4:68,634,844...68,645,112
Ensembl chr 4:68,634,929...68,645,172
JBrowse link
G Stx17 syntaxin 17 affects expression ISO Selenomethionine affects the expression of STX17 mRNA CTD PMID:17222674 NCBI chr 5:63,866,346...63,926,276
Ensembl chr 5:63,870,432...63,922,730
JBrowse link
G Taok2 TAO kinase 2 affects expression ISO Selenomethionine affects the expression of TAOK2 mRNA CTD PMID:17222674 NCBI chr 1:198,301,789...198,354,601
Ensembl chr 1:198,301,938...198,320,075
JBrowse link
G Tbx1 T-box transcription factor 1 affects expression ISO Selenomethionine affects the expression of TBX1 mRNA CTD PMID:17222674 NCBI chr11:86,552,022...86,561,647
Ensembl chr11:86,552,022...86,560,969
JBrowse link
G Tead3 TEA domain transcription factor 3 affects expression ISO Selenomethionine affects the expression of TEAD3 mRNA CTD PMID:17222674 NCBI chr20:7,911,562...7,930,949
Ensembl chr20:7,908,226...7,930,929
JBrowse link
G Tia1 TIA1 cytotoxic granule-associated RNA binding protein multiple interactions ISO Selenomethionine promotes the reaction [TUBA4A protein binds to TIA1 protein] CTD PMID:31585128 NCBI chr 4:118,207,845...118,238,246
Ensembl chr 4:118,207,862...118,235,218
JBrowse link
G Tp53 tumor protein p53 multiple interactions
decreases expression
increases expression
decreases activity
ISO AR protein promotes the reaction [Selenomethionine results in increased expression of TP53 mRNA]; Selenomethionine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased activity of TP53 protein]
Selenomethionine results in decreased expression of TRP53 protein
Diethylhexyl Phthalate inhibits the reaction [Selenomethionine results in decreased expression of TRP53 protein]; Selenomethionine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of TRP53 protein]
Selenomethionine results in decreased activity of TP53 protein
CTD PMID:17100737, PMID:17205524, PMID:20659492, PMID:21515331 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trex1 three prime repair exonuclease 1 affects expression ISO Selenomethionine affects the expression of TREX1 mRNA CTD PMID:17222674 NCBI chr 8:117,796,127...117,797,427
Ensembl chr 8:117,796,128...117,797,427
JBrowse link
G Tsc22d4 TSC22 domain family, member 4 affects expression ISO Selenomethionine affects the expression of TSC22D4 mRNA CTD PMID:17222674 NCBI chr12:22,008,956...22,021,814
Ensembl chr12:22,009,011...22,021,851
JBrowse link
G Tuba4a tubulin, alpha 4A increases glutathionylation
multiple interactions
ISO Selenomethionine results in increased glutathionylation of TUBA4A protein
Selenomethionine promotes the reaction [TUBA4A protein binds to FUS protein]; Selenomethionine promotes the reaction [TUBA4A protein binds to TIA1 protein]
CTD PMID:31585128 NCBI chr 9:82,415,599...82,419,918
Ensembl chr 9:82,415,605...82,419,288
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Selenomethionine results in increased expression of TXNRD1 mRNA; Selenomethionine results in increased expression of TXNRD1 protein CTD PMID:22807314, PMID:31585128 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Txnrd2 thioredoxin reductase 2 affects expression
increases expression
ISO Selenomethionine affects the expression of TXNRD2 mRNA
Selenomethionine results in increased expression of TXNRD2 protein
CTD PMID:17222674, PMID:31585128 NCBI chr11:86,667,994...86,716,063
Ensembl chr11:86,667,997...86,716,254
JBrowse link
G Ube2s ubiquitin-conjugating enzyme E2S affects expression ISO Selenomethionine affects the expression of UBE2S mRNA CTD PMID:17222674 NCBI chr 1:72,580,424...72,584,484
Ensembl chr 1:72,580,424...72,584,482
JBrowse link
G Vps4a vacuolar protein sorting 4 homolog A affects expression ISO Selenomethionine affects the expression of VPS4A mRNA CTD PMID:17222674 NCBI chr19:39,230,050...39,243,298
Ensembl chr19:39,229,754...39,243,496
JBrowse link
G Wwp2 WW domain containing E3 ubiquitin protein ligase 2 affects expression ISO Selenomethionine affects the expression of WWP2 mRNA CTD PMID:17222674 NCBI chr19:39,543,246...39,614,624
Ensembl chr19:39,543,242...39,614,625
JBrowse link
G Xpa XPA, DNA damage recognition and repair factor multiple interactions ISO Selenomethionine inhibits the reaction [Zinc binds to XPA protein] CTD PMID:15265038 NCBI chr 5:61,749,767...61,793,641
Ensembl chr 5:61,749,767...61,792,928
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    chemical entity 19787
      atom 19784
        nonmetal atom 19659
          selenium atom 3123
            selenium molecular entity 3123
              selenomethionines 96
                selenomethionine 96
                  D-selenomethionine + 0
                  L-selenomethionine + 0
                  Se-methylselenomethionine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            heteroorganic entity 19148
                              organochalcogen compound 18856
                                organoselenium compound 593
                                  selenoamino acid 159
                                    selenomethionine 96
                                      D-selenomethionine + 0
                                      L-selenomethionine + 0
                                      Se-methylselenomethionine + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.