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ONTOLOGY REPORT - ANNOTATIONS
Term:aldosterone
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Accession:CHEBI:27584 term browser browse the term
Definition:A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.
Synonyms:exact_synonym: 11beta,21-dihydroxy-3,20-dioxopregn-4-en-18-al
 related_synonym: (11beta)-11,21-dihydroxy-3,20-dioxopregn-4-en-18-al;   11beta,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al;   Formula=C21H28O5;   InChI=1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1;   InChIKey=PQSUYGKTWSAVDQ-ZVIOFETBSA-N;   SMILES=[H][C@@]1(CC[C@@]2([H])[C@]3([H])CCC4=CC(=O)CC[C@]4(C)[C@@]3([H])[C@@H](O)C[C@]12C=O)C(=O)CO
 alt_id: CHEBI:22306;   CHEBI:2563;   CHEBI:40919
 xref: Beilstein:3224996 "ChemIDplus";   CAS:52-39-1 "ChemIDplus";   CAS:52-39-1 "KEGG COMPOUND";   CAS:52-39-1 "NIST Chemistry WebBook";   DrugBank:DB04630;   Drug_Central:111 "DrugCentral";   HMDB:HMDB0000037;   KEGG:C01780;   LINCS:LSM-42770;   LIPID_MAPS_instance:LMST02030026 "LIPID MAPS"
 xref_mesh: MESH:D000450
 xref: PDBeChem:AS4;   PMID:10438974 "Europe PMC";   Reaxys:3224996 "Reaxys";   Wikipedia:Aldosterone

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aldosterone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:6480464
G Acta2 actin alpha 2, smooth muscle JBrowse link 1 252,537,614 252,550,394 RGD:6480464
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:6480464
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:6480464
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:6480464
G Akr1d1 aldo-keto reductase family 1, member D1 JBrowse link 4 65,110,706 65,143,930 RGD:6480464
G Alb albumin JBrowse link 14 19,176,275 19,191,793 RGD:6480464
G Alpl alkaline phosphatase, biomineralization associated JBrowse link 5 156,086,496 156,141,513 RGD:6480464
G Aqp2 aquaporin 2 JBrowse link 7 141,237,802 141,242,837 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Ccn2 cellular communication network factor 2 JBrowse link 1 21,851,657 21,854,773 RGD:6480464
G Cdh1 cadherin 1 JBrowse link 19 38,768,467 38,838,395 RGD:6480464
G Col1a2 collagen type I alpha 2 chain JBrowse link 4 31,534,225 31,569,152 RGD:6480464
G Col3a1 collagen type III alpha 1 chain JBrowse link 9 52,023,295 52,059,221 RGD:6480464
G Col4a1 collagen type IV alpha 1 chain JBrowse link 16 83,522,162 83,632,153 RGD:6480464
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:6480464
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 JBrowse link 7 116,155,928 116,161,781 RGD:6480464
G Dab2 DAB adaptor protein 2 JBrowse link 2 55,747,353 55,768,848 RGD:6480464
G Dhrs3 dehydrogenase/reductase 3 JBrowse link 5 162,809,090 162,843,385 RGD:6480464
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:6480464
G Ednra endothelin receptor type A JBrowse link 19 33,928,356 33,991,703 RGD:6480464
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6480464
G Faslg Fas ligand JBrowse link 13 79,696,811 79,717,581 RGD:6480464
G Gas6 growth arrest specific 6 JBrowse link 16 81,213,364 81,243,824 RGD:6480464
G Gata4 GATA binding protein 4 JBrowse link 15 46,386,703 46,458,679 RGD:6480464
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 8 85,059,051 85,097,471 RGD:6480464
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 JBrowse link 4 81,237,496 81,241,281 RGD:6480464
G Hpse heparanase JBrowse link 14 10,534,358 10,576,686 RGD:6480464
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:6480464
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 JBrowse link 8 33,435,493 33,463,410 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mt1 metallothionein 1 JBrowse link 19 11,301,991 11,303,007 RGD:6480464
G Mtf1 metal-regulatory transcription factor 1 JBrowse link 5 142,797,340 142,843,896 RGD:6480464
G Nedd4l NEDD4 like E3 ubiquitin protein ligase JBrowse link 18 60,392,376 60,719,720 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Nol3 nucleolar protein 3 JBrowse link 19 37,232,567 37,236,668 RGD:6480464
G Nppa natriuretic peptide A JBrowse link 5 164,808,407 164,809,716 RGD:6480464
G Nppb natriuretic peptide B JBrowse link 5 164,796,176 164,797,538 RGD:6480464
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 JBrowse link 18 31,728,373 32,704,022 RGD:6480464
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 JBrowse link 19 34,408,275 34,761,003 RGD:6480464
G Olr1 oxidized low density lipoprotein receptor 1 JBrowse link 4 163,239,853 163,261,937 RGD:6480464
G Pomc proopiomelanocortin JBrowse link 6 28,382,937 28,388,771 RGD:6480464
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:6480464
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Ren renin JBrowse link 13 50,502,724 50,513,953 RGD:6480464
G Scnn1a sodium channel epithelial 1 alpha subunit JBrowse link 4 157,834,339 157,860,472 RGD:6480464
G Scnn1b sodium channel epithelial 1 beta subunit JBrowse link 1 191,829,547 191,883,991 RGD:6480464
G Scnn1g sodium channel epithelial 1 gamma subunit JBrowse link 1 191,704,397 191,738,271 RGD:6480464
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:6480464
G Sgk1 serum/glucocorticoid regulated kinase 1 JBrowse link 1 24,185,451 24,302,309 RGD:6480464
G Slc12a2 solute carrier family 12 member 2 JBrowse link 18 52,917,124 52,985,281 RGD:6480464
G Slc30a1 solute carrier family 30 member 1 JBrowse link 13 110,677,810 110,681,683 RGD:6480464
G Slc39a1 solute carrier family 39 member 1 JBrowse link 2 189,609,766 189,615,367 RGD:6480464
G Slc9a1 solute carrier family 9 member A1 JBrowse link 5 151,573,122 151,626,360 RGD:6480464
G Slc9a3 solute carrier family 9 member A3 JBrowse link 1 31,731,652 31,777,144 RGD:6480464
G Snai1 snail family transcriptional repressor 1 JBrowse link 3 164,274,710 164,279,199 RGD:6480464
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:6480464
G Tat tyrosine aminotransferase JBrowse link 19 41,675,639 41,686,195 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Tsg101 tumor susceptibility 101 JBrowse link 1 102,941,151 102,971,017 RGD:6480464
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 JBrowse link 14 22,597,103 22,619,968 RGD:6480464
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19654
    chemical entity 19652
      group 19568
        organic group 18331
          3-oxo-Delta(4)-steroid group 7902
            3-oxo-Delta(4) steroid 7902
              aldosterone 69
                5beta-dihydroaldosterone 0
                aldosterone hemiacetal 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    p-block element atom 19531
                      carbon group element atom 19413
                        carbon atom 19405
                          organic molecular entity 19405
                            organic group 18331
                              organic divalent group 18321
                                organodiyl group 18321
                                  carbonyl group 18209
                                    carbonyl compound 18209
                                      carboxylic acid 17908
                                        carboacyl group 16930
                                          univalent carboacyl group 16930
                                            formyl group 7675
                                              aldehyde 7675
                                                steroid aldehyde 84
                                                  aldosterone 69
                                                    5beta-dihydroaldosterone 0
                                                    aldosterone hemiacetal 0
paths to the root

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