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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases secretion increases expression multiple interactions |
ISO |
ABCB1 protein results in increased secretion of Aldosterone Aldosterone results in increased expression of ABCB1 mRNA Elacridar inhibits the reaction [ABCB1 protein results in increased secretion of Aldosterone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Aldosterone] |
CTD |
PMID:12387747 PMID:22464980 |
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NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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G |
Ace |
angiotensin I converting enzyme |
increases activity multiple interactions increases expression |
EXP |
Aldosterone results in increased activity of ACE protein AG 1879 inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]; Dactinomycin inhibits the reaction [Aldosterone results in increased activity of ACE protein]; Dactinomycin inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]; Genistein inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]; RTKI cpd inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased activity of ACE protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of ACE mRNA] |
CTD |
PMID:15932931 |
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NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
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G |
Acta2 |
actin alpha 2, smooth muscle |
increases expression multiple interactions |
ISO EXP |
Aldosterone results in increased expression of ACTA2 mRNA; Aldosterone results in increased expression of ACTA2 protein Spironolactone inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein]; tempol inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein] eplerenone inhibits the reaction [Aldosterone results in increased expression of ACTA2 mRNA]; eplerenone inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein]; Rotenone inhibits the reaction [Aldosterone results in increased expression of ACTA2 mRNA]; Rotenone inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein]; U 0126 inhibits the reaction [Aldosterone results in increased expression of ACTA2 mRNA]; U 0126 inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein] |
CTD |
PMID:17596522 PMID:25204689 |
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NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
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G |
Agt |
angiotensinogen |
increases abundance multiple interactions increases secretion increases expression |
ISO EXP |
AGT protein modified form results in increased abundance of Aldosterone; AGT protein results in increased abundance of Aldosterone AGT protein affects the reaction [SLC9A3 gene mutant form results in increased abundance of Aldosterone] AGT protein results in increased secretion of Aldosterone Aldosterone results in increased expression of AGT protein alternative form AGT protein affects the reaction [DAB2 protein results in increased secretion of Aldosterone]; AGT protein alternative form promotes the reaction [Aldosterone results in increased expression of IL18 mRNA] [AGT co-treated with REN] results in increased abundance of Aldosterone; [Valsartan co-treated with benidipine] inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; benidipine inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; candesartan inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]; Clozapine inhibits the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]; Clozapine promotes the reaction [Raclopride promotes the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]]; Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]; efonidipine inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; Enalapril inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]; KCNJ5 protein inhibits the reaction [AGT protein results in increased secretion of Aldosterone]; Losartan inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; Mibefradil inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; naringin inhibits the reaction [AGT protein results in increased secretion of Aldosterone]; Raclopride inhibits the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]; Raclopride promotes the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]; Valsartan inhibits the reaction [AGT protein results in increased abundance of Aldosterone] |
CTD |
PMID:6257467 PMID:7588239 PMID:8952583 PMID:11549694 PMID:16788141 PMID:17303656 PMID:18331727 PMID:18660453 PMID:18679781 PMID:19371736 PMID:20175999 PMID:22452651 PMID:22798349 PMID:25617244 PMID:26564064 |
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NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
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G |
Agtr1a |
angiotensin II receptor, type 1a |
multiple interactions increases expression |
ISO EXP |
[Losartan results in decreased activity of AGTR1 protein] which results in decreased abundance of Aldosterone Aldosterone results in increased expression of AGTR1A mRNA |
CTD |
PMID:9087624 PMID:9124547 PMID:15302841 |
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NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
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G |
Agtr2 |
angiotensin II receptor, type 2 |
increases expression |
EXP |
Aldosterone results in increased expression of AGTR2 mRNA |
CTD |
PMID:15809360 |
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NCBI chr X:119,389,480...119,393,845
Ensembl chr X:119,390,013...119,393,842
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G |
Akr1d1 |
aldo-keto reductase family 1, member D1 |
multiple interactions |
ISO |
[AKR1D1 protein co-treated with NADP] results in increased reduction of Aldosterone |
CTD |
PMID:25500266 |
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NCBI chr 4:65,110,706...65,143,930
Ensembl chr 4:65,110,746...65,143,941
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G |
Alb |
albumin |
multiple interactions |
ISO |
ALB protein inhibits the reaction [Acetaminophen results in increased abundance of Aldosterone] |
CTD |
PMID:1825077 |
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NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
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G |
Alpl |
alkaline phosphatase, biomineralization associated |
multiple interactions increases expression |
ISO |
acephate inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; alachlor inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; Atrazine metabolite inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; bifenthrin inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; cypermethrin inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; DDT inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; Dimethoate inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; fenvalerate inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; fipronil inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; Methoxychlor inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; o,p'-DDT inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; Permethrin inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; terbutylazine inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; Zineb inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA] |
CTD |
PMID:29149346 |
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NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
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G |
Aqp2 |
aquaporin 2 |
multiple interactions |
EXP |
[Aldosterone co-treated with Lithium] affects the expression of AQP2 protein |
CTD |
PMID:16159898 |
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NCBI chr 7:141,237,802...141,242,837
Ensembl chr 7:141,237,768...141,245,165
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G |
Casp3 |
caspase 3 |
multiple interactions |
EXP |
Aldosterone inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein] |
CTD |
PMID:15755911 |
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NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Ccn2 |
cellular communication network factor 2 |
increases expression multiple interactions |
EXP ISO |
Aldosterone results in increased expression of CCN2 protein Aldosterone results in increased expression of CTGF mRNA Spironolactone inhibits the reaction [Aldosterone results in increased expression of CCN2 protein] |
CTD |
PMID:17278980 PMID:30809271 |
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NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
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G |
Cd80 |
Cd80 molecule |
multiple interactions |
EXP |
[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of CD80 mRNA; Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of CD80 mRNA] |
CTD |
PMID:27773435 |
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NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353
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G |
Cdh1 |
cadherin 1 |
decreases expression multiple interactions |
ISO |
Aldosterone results in decreased expression of CDH1 mRNA; Aldosterone results in decreased expression of CDH1 protein eplerenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 mRNA]; eplerenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 protein]; Rotenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 mRNA]; Rotenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 protein]; U 0126 inhibits the reaction [Aldosterone results in decreased expression of CDH1 mRNA]; U 0126 inhibits the reaction [Aldosterone results in decreased expression of CDH1 protein] |
CTD |
PMID:17596522 |
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NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions |
EXP |
[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of COL1A1 mRNA; Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of COL1A1 mRNA] |
CTD |
PMID:27773435 |
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NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
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G |
Col1a2 |
collagen type I alpha 2 chain |
increases expression |
ISO |
Aldosterone results in increased expression of COL1A2 mRNA |
CTD |
PMID:30809271 |
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NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
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G |
Col3a1 |
collagen type III alpha 1 chain |
increases expression multiple interactions |
ISO EXP |
Aldosterone results in increased expression of COL3A1 mRNA [Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of COL3A1 mRNA; Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of COL3A1 mRNA] |
CTD |
PMID:27773435 PMID:30809271 |
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NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
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G |
Col4a1 |
collagen type IV alpha 1 chain |
multiple interactions |
EXP |
[Eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]; Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]; Enalapril inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]; Eplerenone inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]] |
CTD |
PMID:18682491 |
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NCBI chr16:83,522,162...83,632,153
Ensembl chr16:83,522,162...83,632,153
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G |
Crebbp |
CREB binding protein |
multiple interactions |
EXP |
Aldosterone promotes the reaction [NR3C2 protein binds to CREBBP protein]; Aldosterone results in increased expression of and results in increased localization of CREBBP protein |
CTD |
PMID:19966502 |
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NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039
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G |
Cyp11b3 |
cytochrome P450, family 11, subfamily b, polypeptide 3 |
increases chemical synthesis affects chemical synthesis multiple interactions |
ISO EXP |
CYP11B2 protein polymorphism results in increased chemical synthesis of Aldosterone; CYP11B2 protein results in increased chemical synthesis of Aldosterone CYP11B2 protein affects the chemical synthesis of Aldosterone [CYP11B2 protein results in increased hydroxylation of Corticosterone] which results in increased chemical synthesis of Aldosterone |
CTD |
PMID:12525251 PMID:12783697 PMID:16043663 PMID:16054388 PMID:19900470 PMID:21384875 |
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NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
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G |
Dhrs3 |
dehydrogenase/reductase 3 |
multiple interactions |
ISO |
Aldosterone promotes the reaction [[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of DHRS3 protein] |
CTD |
PMID:23275455 |
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NCBI chr 5:162,809,090...162,843,385
Ensembl chr 5:162,808,646...162,843,383
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G |
Edn1 |
endothelin 1 |
increases expression multiple interactions |
EXP |
Aldosterone results in increased expression of EDN1 protein [EDN1 protein binds to and results in increased activity of EDNRA protein] promotes the reaction [Aldosterone results in increased expression of IL18 mRNA] |
CTD |
PMID:18660453 |
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NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
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G |
Ednra |
endothelin receptor type A |
multiple interactions |
EXP |
[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; [EDN1 protein binds to and results in increased activity of EDNRA protein] promotes the reaction [Aldosterone results in increased expression of IL18 mRNA] |
CTD |
PMID:18660453 |
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NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703
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G |
Egfr |
epidermal growth factor receptor |
increases expression |
EXP |
Aldosterone results in increased expression of EGFR mRNA |
CTD |
PMID:11507004 |
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NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
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G |
F2r |
coagulation factor II (thrombin) receptor |
multiple interactions |
EXP |
[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of F2R mRNA |
CTD |
PMID:27773435 |
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NCBI chr 2:26,118,760...26,135,340
Ensembl chr 2:26,118,760...26,135,340
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G |
Faslg |
Fas ligand |
increases expression |
EXP |
Aldosterone results in increased expression of FASLG protein |
CTD |
PMID:19001025 |
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NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
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G |
Gas6 |
growth arrest specific 6 |
increases expression multiple interactions |
EXP |
Aldosterone results in increased expression of GAS6 protein NR3C2 protein promotes the reaction [Aldosterone results in increased expression of GAS6 protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of GAS6 protein] |
CTD |
PMID:19564549 |
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NCBI chr16:81,213,364...81,243,824
Ensembl chr16:81,213,364...81,243,757
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G |
Gata4 |
GATA binding protein 4 |
increases expression |
EXP |
Aldosterone results in increased expression of GATA4 protein |
CTD |
PMID:19966502 |
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NCBI chr15:46,386,703...46,458,679
Ensembl chr15:46,386,712...46,432,965
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression multiple interactions |
EXP |
Aldosterone results in increased expression of GCLC protein Spironolactone inhibits the reaction [Aldosterone results in increased expression of GCLC protein]; tempol inhibits the reaction [Aldosterone results in increased expression of GCLC protein] |
CTD |
PMID:24512358 PMID:25204689 |
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NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
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G |
Gstp1 |
glutathione S-transferase pi 1 |
increases expression |
EXP |
Aldosterone results in increased expression of GSTP1 protein |
CTD |
PMID:25204689 |
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NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
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G |
Hmox1 |
heme oxygenase 1 |
increases expression |
EXP |
Aldosterone results in increased expression of HMOX1 protein |
CTD |
PMID:25204689 |
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NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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G |
Hnrnpa2b1 |
heterogeneous nuclear ribonucleoprotein A2/B1 |
increases expression |
EXP |
Aldosterone results in increased expression of HNRNPA2B1 mRNA; Aldosterone results in increased expression of HNRNPA2B1 protein |
CTD |
PMID:23139218 |
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NCBI chr 4:81,237,496...81,241,281
Ensembl chr 4:81,237,496...81,241,282
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G |
Hpse |
heparanase |
increases expression multiple interactions |
EXP |
Aldosterone results in increased expression of HPSE mRNA; Aldosterone results in increased expression of HPSE protein Spironolactone inhibits the reaction [Aldosterone results in increased expression of HPSE mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of HPSE protein] |
CTD |
PMID:19429930 |
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NCBI chr14:10,534,358...10,576,686
Ensembl chr14:10,534,423...10,575,224
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G |
Il18 |
interleukin 18 |
increases expression multiple interactions |
EXP |
Aldosterone results in increased expression of IL18 mRNA; Aldosterone results in increased expression of IL18 protein [cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; [EDN1 protein binds to and results in increased activity of EDNRA protein] promotes the reaction [Aldosterone results in increased expression of IL18 mRNA]; AGT protein alternative form promotes the reaction [Aldosterone results in increased expression of IL18 mRNA]; Bezafibrate inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; Cycloheximide inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; Eplerenone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; exoenzyme C3, Clostridium botulinum inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; fasudil inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]]; olmesartan inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; Pioglitazone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; prolinedithiocarbamate inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; Simvastatin inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; SN50 peptide inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] |
CTD |
PMID:18660453 |
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NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
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G |
Il6 |
interleukin 6 |
increases expression |
ISO |
Aldosterone results in increased expression of IL6 protein |
CTD |
PMID:17043157 |
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NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Jak2 |
Janus kinase 2 |
increases phosphorylation multiple interactions |
EXP |
Aldosterone results in increased phosphorylation of JAK2 protein Dactinomycin inhibits the reaction [Aldosterone results in increased phosphorylation of JAK2 protein]; Spironolactone inhibits the reaction [Aldosterone results in increased phosphorylation of JAK2 protein] |
CTD |
PMID:15932931 |
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NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
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G |
Kcnj5 |
potassium inwardly-rectifying channel, subfamily J, member 5 |
multiple interactions decreases secretion |
ISO |
KCNJ5 protein inhibits the reaction [AGT protein results in increased secretion of Aldosterone] KCNJ5 protein results in decreased secretion of Aldosterone |
CTD |
PMID:22798349 |
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NCBI chr 8:33,435,493...33,463,410
Ensembl chr 8:33,433,905...33,463,467
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Aldosterone results in increased phosphorylation of and results in increased activity of MAPK1 protein; eplerenone inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Rotenone inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK1 protein] |
CTD |
PMID:17596522 |
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NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk14 |
mitogen activated protein kinase 14 |
affects chemical synthesis |
ISO |
MAPK14 protein affects the chemical synthesis of Aldosterone |
CTD |
PMID:14592955 |
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NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Aldosterone results in increased phosphorylation of and results in increased activity of MAPK3 protein; eplerenone inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Rotenone inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK3 protein] |
CTD |
PMID:17596522 |
|
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Mt1 |
metallothionein 1 |
multiple interactions increases expression |
EXP |
[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased expression of MT1A protein; Amlodipine inhibits the reaction [Aldosterone results in increased expression of MT1A mRNA]; Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased expression of MT1A protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of MT1A mRNA] |
CTD |
PMID:17616752 PMID:19333130 |
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NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
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G |
Mtf1 |
metal-regulatory transcription factor 1 |
increases expression multiple interactions |
EXP |
Aldosterone results in increased expression of MTF1 mRNA; Aldosterone results in increased expression of MTF1 protein Amlodipine inhibits the reaction [Aldosterone results in increased expression of MTF1 mRNA]; Amlodipine inhibits the reaction [Aldosterone results in increased expression of MTF1 protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of MTF1 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of MTF1 protein] |
CTD |
PMID:19333130 |
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NCBI chr 5:142,797,340...142,843,896
Ensembl chr 5:142,797,366...142,842,122
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G |
Nedd4l |
NEDD4 like E3 ubiquitin protein ligase |
multiple interactions |
ISO |
Aldosterone inhibits the reaction [NEDD4L gene mutant form results in decreased cleavage of SCNN1A protein] |
CTD |
PMID:23348737 |
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NCBI chr18:60,392,376...60,719,720
Ensembl chr18:60,392,376...60,719,720
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G |
Nfe2l2 |
nuclear factor, erythroid 2-like 2 |
increases activity multiple interactions |
EXP |
Aldosterone results in increased activity of NFE2L2 protein Spironolactone inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]; tempol inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein] |
CTD |
PMID:25204689 |
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NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
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G |
Nol3 |
nucleolar protein 3 |
decreases phosphorylation |
EXP |
Aldosterone results in decreased phosphorylation of NOL3 protein |
CTD |
PMID:19001025 |
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NCBI chr19:37,232,567...37,236,668
Ensembl chr19:37,235,001...37,236,649
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G |
Nppa |
natriuretic peptide A |
multiple interactions decreases secretion increases expression |
EXP ISO |
Aldosterone promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of NPPA mRNA] NPPA protein results in decreased secretion of Aldosterone |
CTD |
PMID:2434734 PMID:2931268 PMID:19966502 |
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NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
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G |
Nppb |
natriuretic peptide B |
decreases abundance affects abundance |
ISO |
NPPB protein results in decreased abundance of Aldosterone NPPB affects the abundance of Aldosterone |
CTD |
PMID:16333235 PMID:20339970 |
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NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
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G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
multiple interactions affects binding increases activity decreases expression |
ISO EXP |
Aldosterone binds to and results in increased activity of NR3C1 protein NR3C1 protein binds to Aldosterone Aldosterone promotes the reaction [[NR3C1 protein binds to TAT promoter] which results in increased expression of TAT mRNA] Aldosterone results in increased activity of NR3C1 protein Aldosterone results in decreased expression of NR3C1 mRNA Aldosterone binds to NR3C1 protein mutant form |
CTD |
PMID:1597467 PMID:8969928 PMID:11861974 PMID:15362971 PMID:15774500 PMID:22465009 |
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NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
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G |
Nr3c2 |
nuclear receptor subfamily 3, group C, member 2 |
multiple interactions increases activity increases phosphorylation decreases expression affects localization increases expression affects binding |
ISO EXP |
4,4'-hexafluorisopropylidene diphenol inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; acephate inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; acephate inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; alachlor inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; alachlor inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; Aldosterone binds to and results in increased activity of NR3C2 protein; Aldosterone inhibits the reaction [TSG101 protein binds to NR3C2 protein]; Aldosterone results in decreased expression of and affects the ubiquitination of NR3C2 protein; Atrazine metabolite inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; Atrazine metabolite inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; bifenthrin inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; bifenthrin inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; bisphenol A inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; bisphenol B inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; cypermethrin inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; cypermethrin inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; DDT inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; DDT inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; Dihydrotestosterone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; Dimethoate inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; Dimethoate inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; fenvalerate inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; fipronil inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; Methoxychlor inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; Methoxychlor inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; Metribolone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; o,p'-DDT inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; o,p'-DDT inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; Permethrin inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; Permethrin inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; Pesticides inhibits the reaction [Aldosterone results in increased expression of NR3C2 mRNA]; Soil Pollutants inhibits the reaction [Aldosterone results in increased expression of NR3C2 mRNA]; Spironolactone inhibits the reaction [Aldosterone affects the ubiquitination of NR3C2 protein]; Spironolactone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; terbutylazine inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; terbutylazine inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; Testosterone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; Zineb inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; Zineb inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein] Aldosterone results in increased phosphorylation of NR3C2 protein Aldosterone results in decreased expression of NR3C2 protein Aldosterone inhibits the reaction [TSG101 protein binds to NR3C2 protein]; FR 180204 inhibits the reaction [Aldosterone results in increased phosphorylation of NR3C2 protein] Aldosterone results in increased expression of NR3C2 mRNA; Aldosterone results in increased expression of NR3C2 protein Aldosterone binds to NR3C2 protein Aldosterone results in decreased expression of NR3C2 mRNA Aldosterone promotes the reaction [NR3C2 protein binds to CREBBP protein]; Aldosterone results in increased expression of and results in increased localization of NR3C2 protein; NR3C2 protein promotes the reaction [Aldosterone results in increased expression of GAS6 protein]; torsemide inhibits the reaction [Aldosterone binds to NR3C2 protein] |
CTD |
PMID:7954537 PMID:8798622 PMID:8969928 PMID:15362971 PMID:15780662 PMID:15974890 PMID:17105867 PMID:17596522 PMID:19564549 PMID:19966502 PMID:20207834 PMID:20508287 PMID:22798426 PMID:29149346 PMID:29248852 PMID:30951782 |
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NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
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G |
Olr1 |
oxidized low density lipoprotein receptor 1 |
multiple interactions increases expression |
ISO |
Spironolactone inhibits the reaction [Aldosterone results in increased expression of OLR1 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of OLR1 protein] Aldosterone results in increased expression of OLR1 mRNA; Aldosterone results in increased expression of OLR1 protein |
CTD |
PMID:20508287 |
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NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958
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G |
Plat |
plasminogen activator, tissue type |
multiple interactions |
EXP |
[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of PLAT mRNA |
CTD |
PMID:27773435 |
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NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
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G |
Plg |
plasminogen |
multiple interactions |
EXP |
[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased activity of PLG protein modified form |
CTD |
PMID:27773435 |
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NCBI chr 1:48,521,828...48,563,895
Ensembl chr 1:48,521,772...48,563,776
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G |
Pomc |
proopiomelanocortin |
multiple interactions increases secretion increases abundance decreases abundance |
ISO EXP |
Dexamethasone inhibits the reaction [POMC protein results in increased abundance of Aldosterone] POMC results in increased secretion of Aldosterone POMC protein results in decreased abundance of Aldosterone |
CTD |
PMID:1659878 PMID:2551692 PMID:3015796 |
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NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
affects abundance |
ISO |
PPARG protein affects the abundance of Aldosterone |
CTD |
PMID:16007095 |
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NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
increases expression |
EXP |
Aldosterone results in increased expression of PPARGC1A mRNA |
CTD |
PMID:19808358 |
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NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
increases activity multiple interactions |
EXP |
Aldosterone results in increased activity of RELA protein Bezafibrate inhibits the reaction [Aldosterone results in increased activity of RELA protein]; pioglitazone inhibits the reaction [Aldosterone results in increased activity of RELA protein]; prolinedithiocarbamate inhibits the reaction [Aldosterone results in increased activity of RELA protein]; SN50 peptide inhibits the reaction [Aldosterone results in increased activity of RELA protein] |
CTD |
PMID:18660453 |
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NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Ren |
renin |
multiple interactions |
ISO |
[AGT co-treated with REN] results in increased abundance of Aldosterone; candesartan inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]; Enalapril inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone] |
CTD |
PMID:18679781 |
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NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
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G |
Scnn1a |
sodium channel epithelial 1 subunit alpha |
increases expression multiple interactions affects expression |
ISO |
Aldosterone results in increased expression of SCNN1A mRNA; Aldosterone results in increased expression of SCNN1A protein Aldosterone inhibits the reaction [NEDD4L gene mutant form results in decreased cleavage of SCNN1A protein] Aldosterone affects the expression of SCNN1A mRNA |
CTD |
PMID:16555725 PMID:18665318 PMID:23348737 |
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NCBI chr 4:157,834,339...157,860,472
Ensembl chr 4:157,836,912...157,860,049
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G |
Scnn1b |
sodium channel epithelial 1 subunit beta |
increases expression |
ISO |
Aldosterone results in increased expression of SCNN1B mRNA; Aldosterone results in increased expression of SCNN1B protein |
CTD |
PMID:18665318 |
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NCBI chr 1:191,829,547...191,883,991
Ensembl chr 1:191,829,555...191,884,298
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G |
Scnn1g |
sodium channel epithelial 1 subunit gamma |
increases expression |
ISO |
Aldosterone results in increased expression of SCNN1G mRNA; Aldosterone results in increased expression of SCNN1G protein |
CTD |
PMID:18665318 |
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NCBI chr 1:191,704,397...191,738,271
Ensembl chr 1:191,704,311...191,738,268
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G |
Serpine1 |
serpin family E member 1 |
multiple interactions increases expression |
EXP ISO |
[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA; [Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein; [Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of SERPINE1 mRNA; [Eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; [Eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]; Eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; Eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein] Aldosterone results in increased expression of SERPINE1 mRNA |
CTD |
PMID:18682491 PMID:27773435 PMID:30809271 |
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NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
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G |
Sgk1 |
serum/glucocorticoid regulated kinase 1 |
multiple interactions decreases expression increases expression |
EXP ISO |
Spironolactone inhibits the reaction [Aldosterone results in increased expression of SGK1 mRNA] Aldosterone results in decreased expression of SGK1 protein TSG101 mutant form inhibits the reaction [Aldosterone results in decreased expression of SGK1 protein] |
CTD |
PMID:15130897 PMID:19429930 PMID:22798426 |
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NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
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G |
Slc12a2 |
solute carrier family 12 member 2 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Aldosterone results in increased activity of SLC12A2 protein] |
CTD |
PMID:12668585 |
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NCBI chr18:52,917,124...52,985,281
Ensembl chr18:52,917,124...52,985,261
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G |
Slc30a1 |
solute carrier family 30 member 1 |
multiple interactions increases expression |
EXP |
Spironolactone inhibits the reaction [Aldosterone results in increased expression of SLC30A1 mRNA] |
CTD |
PMID:19333130 |
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NCBI chr13:110,677,810...110,681,683
Ensembl chr13:110,677,810...110,681,683
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G |
Slc39a1 |
solute carrier family 39 member 1 |
multiple interactions increases expression |
EXP |
Spironolactone inhibits the reaction [Aldosterone results in increased expression of SLC39A1 mRNA] |
CTD |
PMID:19333130 |
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NCBI chr 2:189,609,766...189,615,367
Ensembl chr 2:189,609,800...189,615,366
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G |
Slc9a1 |
solute carrier family 9 member A1 |
increases expression multiple interactions |
EXP |
Aldosterone results in increased expression of SLC9A1 mRNA eplerenone inhibits the reaction [Aldosterone results in increased expression of SLC9A1 mRNA] |
CTD |
PMID:16373419 |
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NCBI chr 5:151,573,122...151,626,360
Ensembl chr 5:151,573,092...151,627,316
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G |
Slc9a3 |
solute carrier family 9 member A3 |
multiple interactions increases abundance |
ISO |
AGT protein affects the reaction [SLC9A3 gene mutant form results in increased abundance of Aldosterone] |
CTD |
PMID:26564064 |
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NCBI chr 1:31,731,652...31,777,144
Ensembl chr 1:31,734,327...31,777,070
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G |
Snai1 |
snail family transcriptional repressor 1 |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA]; eplerenone inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA]; Rotenone inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA]; U 0126 inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA] |
CTD |
PMID:17596522 |
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NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions increases activity |
EXP |
[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in decreased activity of SOD1 protein; [Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased activity of SOD1 protein; Amlodipine inhibits the reaction [Aldosterone results in increased activity of SOD1 protein]; Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in decreased activity of SOD1 protein]; Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased activity of SOD1 protein]; Spironolactone inhibits the reaction [Aldosterone results in increased activity of SOD1 protein] |
CTD |
PMID:17616752 PMID:19333130 |
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NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
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G |
Tat |
tyrosine aminotransferase |
multiple interactions |
EXP |
Aldosterone promotes the reaction [[NR3C1 protein binds to TAT promoter] which results in increased expression of TAT mRNA] |
CTD |
PMID:22465009 |
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NCBI chr19:41,675,639...41,686,195
Ensembl chr19:41,675,355...41,686,229
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G |
Tgfb1 |
transforming growth factor, beta 1 |
increases secretion multiple interactions increases expression |
EXP |
Aldosterone results in increased secretion of TGFB1 protein [Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein; [Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TGFB1 mRNA; [Eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; [Eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]; Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; Enalapril inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]; Eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TGFB1 mRNA]; Eplerenone inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of TGFB1 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased secretion of TGFB1 protein]; tempol inhibits the reaction [Aldosterone results in increased expression of TGFB1 mRNA] |
CTD |
PMID:15130897 PMID:18682491 PMID:25204689 PMID:27773435 |
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NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TNF mRNA; Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TNF mRNA] |
CTD |
PMID:27773435 |
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NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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G |
Tsg101 |
tumor susceptibility 101 |
multiple interactions |
ISO |
Aldosterone inhibits the reaction [TSG101 protein binds to NR3C2 protein]; TSG101 mutant form inhibits the reaction [Aldosterone results in decreased expression of SGK1 protein] |
CTD |
PMID:22798426 |
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NCBI chr 1:102,941,151...102,971,017
Ensembl chr 1:102,941,231...102,970,950
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G |
Ugt2b7 |
UDP glucuronosyltransferase family 2 member B7 |
multiple interactions increases glucuronidation |
ISO |
alclofenac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; cicloprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Diclofenac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Diflunisal inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Fenoprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Ibuprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Indomethacin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Ketoprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Ketorolac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Meclofenamic Acid inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Mefenamic Acid inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Naproxen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; pirprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; tiaprofenic acid inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone] |
CTD |
PMID:19740398 |
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NCBI chr14:22,597,103...22,619,968
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