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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:aldosterone
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Accession:CHEBI:27584 term browser browse the term
Definition:A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.
Synonyms:exact_synonym: 11beta,21-dihydroxy-3,20-dioxopregn-4-en-18-al
 related_synonym: (11beta)-11,21-dihydroxy-3,20-dioxopregn-4-en-18-al;   11beta,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al;   Formula=C21H28O5;   InChI=1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1;   InChIKey=PQSUYGKTWSAVDQ-ZVIOFETBSA-N;   SMILES=[H][C@@]1(CC[C@@]2([H])[C@]3([H])CCC4=CC(=O)CC[C@]4(C)[C@@]3([H])[C@@H](O)C[C@]12C=O)C(=O)CO
 alt_id: CHEBI:22306;   CHEBI:2563;   CHEBI:40919
 xref: Beilstein:3224996;   CAS:52-39-1;   DrugBank:DB04630;   Drug_Central:111;   HMDB:HMDB0000037;   KEGG:C01780;   LINCS:LSM-42770;   LIPID_MAPS_instance:LMST02030026
 xref_mesh: MESH:D000450
 xref: PDBeChem:AS4;   PMID:10438974;   Reaxys:3224996;   Wikipedia:Aldosterone


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aldosterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases secretion
multiple interactions
increases expression		 ISO ABCB1 protein results in increased secretion of Aldosterone
Elacridar inhibits the reaction [ABCB1 protein results in increased secretion of Aldosterone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Aldosterone]
Aldosterone results in increased expression of ABCB1 mRNA		 CTD PMID:12387747 PMID:22464980 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Ace angiotensin I converting enzyme increases activity
multiple interactions
increases expression		 EXP Aldosterone results in increased activity of ACE protein
AG 1879 inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]; Dactinomycin inhibits the reaction [Aldosterone results in increased activity of ACE protein]; Dactinomycin inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]; Genistein inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]; RTKI cpd inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased activity of ACE protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]		 CTD PMID:15932931 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression
multiple interactions		 ISO
EXP		 Aldosterone results in increased expression of ACTA2 mRNA; Aldosterone results in increased expression of ACTA2 protein
eplerenone inhibits the reaction [Aldosterone results in increased expression of ACTA2 mRNA]; eplerenone inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein]; Rotenone inhibits the reaction [Aldosterone results in increased expression of ACTA2 mRNA]; Rotenone inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein]; U 0126 inhibits the reaction [Aldosterone results in increased expression of ACTA2 mRNA]; U 0126 inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein]
Spironolactone inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein]; tempol inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein]		 CTD PMID:17596522 PMID:25204689 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Agt angiotensinogen increases abundance
multiple interactions
increases secretion
increases expression		 ISO
EXP		 AGT protein modified form results in increased abundance of Aldosterone; AGT protein results in increased abundance of Aldosterone
[AGT co-treated with REN] results in increased abundance of Aldosterone; [Valsartan co-treated with benidipine] inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; benidipine inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; candesartan inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]; Clozapine inhibits the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]; Clozapine promotes the reaction [Raclopride promotes the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]]; Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]; efonidipine inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; Enalapril inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]; KCNJ5 protein inhibits the reaction [AGT protein results in increased secretion of Aldosterone]; Losartan inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; Mibefradil inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; naringin inhibits the reaction [AGT protein results in increased secretion of Aldosterone]; Raclopride inhibits the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]; Raclopride promotes the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]; Valsartan inhibits the reaction [AGT protein results in increased abundance of Aldosterone]
AGT protein affects the reaction [DAB2 protein results in increased secretion of Aldosterone]; AGT protein alternative form promotes the reaction [Aldosterone results in increased expression of IL18 mRNA]
Aldosterone results in increased expression of AGT protein alternative form
AGT protein affects the reaction [SLC9A3 gene mutant form results in increased abundance of Aldosterone]		 CTD PMID:6257467 PMID:7588239 PMID:8952583 PMID:11549694 PMID:16788141 More... NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions
increases expression		 ISO
EXP		 [Losartan results in decreased activity of AGTR1 protein] which results in decreased abundance of Aldosterone
Aldosterone results in increased expression of AGTR1A mRNA		 CTD PMID:9087624 PMID:9124547 PMID:15302841 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 increases expression EXP Aldosterone results in increased expression of AGTR2 mRNA CTD PMID:15809360 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 multiple interactions ISO [AKR1D1 protein co-treated with NADP] results in increased reduction of Aldosterone CTD PMID:25500266 NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372 		JBrowse link
G Alb albumin multiple interactions ISO ALB protein inhibits the reaction [Acetaminophen results in increased abundance of Aldosterone] CTD PMID:1825077 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions
increases expression		 ISO acephate inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; alachlor inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; Atrazine metabolite inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; bifenthrin inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; cypermethrin inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; DDT inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; Dimethoate inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; fenvalerate inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; fipronil inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; Methoxychlor inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; o,p'-DDT inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; Permethrin inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; terbutylazine inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; Zineb inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA] CTD PMID:29149346 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Aqp2 aquaporin 2 multiple interactions EXP [Aldosterone co-treated with Lithium] affects the expression of AQP2 protein CTD PMID:16159898 NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP Aldosterone inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein] CTD PMID:15755911 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccn2 cellular communication network factor 2 increases expression
multiple interactions		 EXP
ISO		 Aldosterone results in increased expression of CCN2 protein
Spironolactone inhibits the reaction [Aldosterone results in increased expression of CCN2 protein]
Aldosterone results in increased expression of CCN2 mRNA		 CTD PMID:17278980 PMID:30809271 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Cd80 Cd80 molecule multiple interactions EXP [Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of CD80 mRNA; Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of CD80 mRNA] CTD PMID:27773435 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030 		JBrowse link
G Cdh1 cadherin 1 decreases expression
multiple interactions		 ISO Aldosterone results in decreased expression of CDH1 mRNA; Aldosterone results in decreased expression of CDH1 protein
eplerenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 mRNA]; eplerenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 protein]; Rotenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 mRNA]; Rotenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 protein]; U 0126 inhibits the reaction [Aldosterone results in decreased expression of CDH1 mRNA]; U 0126 inhibits the reaction [Aldosterone results in decreased expression of CDH1 protein]		 CTD PMID:17596522 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP [Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of COL1A1 mRNA; Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of COL1A1 mRNA] CTD PMID:27773435 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col1a2 collagen type I alpha 2 chain increases expression ISO Aldosterone results in increased expression of COL1A2 mRNA CTD PMID:30809271 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867 		JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression
multiple interactions		 ISO
EXP		 Aldosterone results in increased expression of COL3A1 mRNA
[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of COL3A1 mRNA; Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of COL3A1 mRNA]		 CTD PMID:27773435 PMID:30809271 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Col4a1 collagen type IV alpha 1 chain multiple interactions EXP [Eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]; Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]; Enalapril inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]; Eplerenone inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]] CTD PMID:18682491 NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412 		JBrowse link
G Crebbp CREB binding protein multiple interactions EXP Aldosterone promotes the reaction [NR3C2 protein binds to CREBBP protein]; Aldosterone results in increased expression of and results in increased localization of CREBBP protein CTD PMID:19966502 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases chemical synthesis
affects chemical synthesis
multiple interactions		 ISO
EXP		 CYP11B2 protein polymorphism results in increased chemical synthesis of Aldosterone; CYP11B2 protein results in increased chemical synthesis of Aldosterone
CYP11B2 protein affects the chemical synthesis of Aldosterone
[CYP11B2 protein results in increased hydroxylation of Corticosterone] which results in increased chemical synthesis of Aldosterone		 CTD PMID:12525251 PMID:12783697 PMID:15731365 PMID:16043663 PMID:16054388 More... NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
G Dab2 DAB adaptor protein 2 multiple interactions EXP AGT protein affects the reaction [DAB2 protein results in increased secretion of Aldosterone] CTD PMID:17303656 NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476 		JBrowse link
G Dhrs3 dehydrogenase/reductase 3 multiple interactions ISO Aldosterone promotes the reaction [[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of DHRS3 protein] CTD PMID:23275455 NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417 		JBrowse link
G Edn1 endothelin 1 increases expression
multiple interactions		 EXP Aldosterone results in increased expression of EDN1 protein
[EDN1 protein binds to and results in increased activity of EDNRA protein] promotes the reaction [Aldosterone results in increased expression of IL18 mRNA]		 CTD PMID:18660453 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ednra endothelin receptor type A multiple interactions EXP [cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; [EDN1 protein binds to and results in increased activity of EDNRA protein] promotes the reaction [Aldosterone results in increased expression of IL18 mRNA] CTD PMID:18660453 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Egfr epidermal growth factor receptor increases expression EXP Aldosterone results in increased expression of EGFR mRNA CTD PMID:11507004 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G F2r coagulation factor II (thrombin) receptor multiple interactions EXP [Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of F2R mRNA CTD PMID:27773435 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870 		JBrowse link
G Faslg Fas ligand increases expression EXP Aldosterone results in increased expression of FASLG protein CTD PMID:19001025 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Gas6 growth arrest specific 6 increases expression
multiple interactions		 EXP Aldosterone results in increased expression of GAS6 protein
NR3C2 protein promotes the reaction [Aldosterone results in increased expression of GAS6 protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of GAS6 protein]		 CTD PMID:19564549 NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904 		JBrowse link
G Gata4 GATA binding protein 4 increases expression EXP Aldosterone results in increased expression of GATA4 protein CTD PMID:19966502 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions		 EXP Aldosterone results in increased expression of GCLC protein
Spironolactone inhibits the reaction [Aldosterone results in increased expression of GCLC protein]; tempol inhibits the reaction [Aldosterone results in increased expression of GCLC protein]		 CTD PMID:24512358 PMID:25204689 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP Aldosterone results in increased expression of GSTP1 protein CTD PMID:25204689 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Aldosterone results in increased expression of HMOX1 protein CTD PMID:25204689 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 increases expression EXP Aldosterone results in increased expression of HNRNPA2B1 mRNA; Aldosterone results in increased expression of HNRNPA2B1 protein CTD PMID:23139218 NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249 		JBrowse link
G Hpse heparanase increases expression
multiple interactions		 EXP Aldosterone results in increased expression of HPSE mRNA; Aldosterone results in increased expression of HPSE protein
Spironolactone inhibits the reaction [Aldosterone results in increased expression of HPSE mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of HPSE protein]		 CTD PMID:19429930 NCBI chr14:8,896,593...8,937,011
Ensembl chr14:8,896,593...8,937,010 		JBrowse link
G Il18 interleukin 18 increases expression
multiple interactions		 EXP Aldosterone results in increased expression of IL18 mRNA; Aldosterone results in increased expression of IL18 protein
[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; [EDN1 protein binds to and results in increased activity of EDNRA protein] promotes the reaction [Aldosterone results in increased expression of IL18 mRNA]; AGT protein alternative form promotes the reaction [Aldosterone results in increased expression of IL18 mRNA]; Bezafibrate inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; Cycloheximide inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; Eplerenone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; exoenzyme C3, Clostridium botulinum inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; fasudil inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]]; olmesartan inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; Pioglitazone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; prolinedithiocarbamate inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; Simvastatin inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; SN50 peptide inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]		 CTD PMID:18660453 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il6 interleukin 6 increases expression ISO Aldosterone results in increased expression of IL6 protein CTD PMID:17043157 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jak2 Janus kinase 2 increases phosphorylation
multiple interactions		 EXP Aldosterone results in increased phosphorylation of JAK2 protein
Dactinomycin inhibits the reaction [Aldosterone results in increased phosphorylation of JAK2 protein]; Spironolactone inhibits the reaction [Aldosterone results in increased phosphorylation of JAK2 protein]		 CTD PMID:15932931 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 multiple interactions
decreases secretion		 ISO KCNJ5 protein inhibits the reaction [AGT protein results in increased secretion of Aldosterone]
KCNJ5 protein results in decreased secretion of Aldosterone		 CTD PMID:22798349 NCBI chr 8:30,724,923...30,753,083
Ensembl chr 8:30,724,925...30,753,518 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Acetylcysteine inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Aldosterone results in increased phosphorylation of and results in increased activity of MAPK1 protein; eplerenone inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Rotenone inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:17596522 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 affects chemical synthesis ISO MAPK14 protein affects the chemical synthesis of Aldosterone CTD PMID:14592955 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Acetylcysteine inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Aldosterone results in increased phosphorylation of and results in increased activity of MAPK3 protein; eplerenone inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Rotenone inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:17596522 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mt1 metallothionein 1 multiple interactions
increases expression		 EXP [Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased expression of MT1A protein; Amlodipine inhibits the reaction [Aldosterone results in increased expression of MT1A mRNA]; Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased expression of MT1A protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of MT1A mRNA] CTD PMID:17616752 PMID:19333130 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049 		JBrowse link
G Mtf1 metal-regulatory transcription factor 1 increases expression
multiple interactions		 EXP Aldosterone results in increased expression of MTF1 mRNA; Aldosterone results in increased expression of MTF1 protein
Amlodipine inhibits the reaction [Aldosterone results in increased expression of MTF1 mRNA]; Amlodipine inhibits the reaction [Aldosterone results in increased expression of MTF1 protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of MTF1 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of MTF1 protein]		 CTD PMID:19333130 NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136 		JBrowse link
G Nedd4l NEDD4 like E3 ubiquitin protein ligase multiple interactions ISO Aldosterone inhibits the reaction [NEDD4L gene mutant form results in decreased cleavage of SCNN1A protein] CTD PMID:23348737 NCBI chr18:58,393,759...58,726,709
Ensembl chr18:58,393,509...58,723,137 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases activity
multiple interactions		 EXP Aldosterone results in increased activity of NFE2L2 protein
Spironolactone inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]; tempol inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]		 CTD PMID:25204689 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nol3 nucleolar protein 3 decreases phosphorylation EXP Aldosterone results in decreased phosphorylation of NOL3 protein CTD PMID:19001025 NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250 		JBrowse link
G Nppa natriuretic peptide A multiple interactions
increases expression
decreases secretion		 EXP
ISO		 Aldosterone promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of NPPA mRNA]
NPPA protein results in decreased secretion of Aldosterone		 CTD PMID:2434734 PMID:2931268 PMID:19966502 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B decreases abundance
affects abundance		 ISO NPPB protein results in decreased abundance of Aldosterone
NPPB affects the abundance of Aldosterone		 CTD PMID:16333235 PMID:20339970 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
affects binding
decreases expression
increases activity		 ISO
EXP		 Aldosterone binds to and results in increased activity of NR3C1 protein
Aldosterone binds to NR3C1 protein mutant form
Aldosterone results in decreased expression of NR3C1 mRNA
Aldosterone results in increased activity of NR3C1 protein
Aldosterone promotes the reaction [[NR3C1 protein binds to TAT promoter] which results in increased expression of TAT mRNA]
NR3C1 protein binds to Aldosterone		 CTD PMID:1597467 PMID:8969928 PMID:11861974 PMID:15362971 PMID:15774500 More... NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions
affects localization
decreases expression
increases activity
affects binding
increases expression
increases phosphorylation		 ISO
EXP		 4,4'-hexafluorisopropylidene diphenol inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; acephate inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; acephate inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; alachlor inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; alachlor inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; Aldosterone binds to and results in increased activity of NR3C2 protein; Aldosterone inhibits the reaction [TSG101 protein binds to NR3C2 protein]; Aldosterone results in decreased expression of and affects the ubiquitination of NR3C2 protein; Atrazine metabolite inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; Atrazine metabolite inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; bifenthrin inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; bifenthrin inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; bisphenol A inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; bisphenol B inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; cypermethrin inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; cypermethrin inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; DDT inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; DDT inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; Dihydrotestosterone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; Dimethoate inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; Dimethoate inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; fenvalerate inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; fipronil inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; Methoxychlor inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; Methoxychlor inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; Metribolone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; o,p'-DDT inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; o,p'-DDT inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; Permethrin inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; Permethrin inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; Pesticides inhibits the reaction [Aldosterone results in increased expression of NR3C2 mRNA]; Soil Pollutants inhibits the reaction [Aldosterone results in increased expression of NR3C2 mRNA]; Spironolactone inhibits the reaction [Aldosterone affects the ubiquitination of NR3C2 protein]; Spironolactone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; terbutylazine inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; terbutylazine inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; Testosterone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]; Zineb inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; Zineb inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]
Aldosterone promotes the reaction [NR3C2 protein binds to CREBBP protein]; Aldosterone results in increased expression of and results in increased localization of NR3C2 protein; NR3C2 protein promotes the reaction [Aldosterone results in increased expression of GAS6 protein]; torsemide inhibits the reaction [Aldosterone binds to NR3C2 protein]
Aldosterone results in decreased expression of NR3C2 mRNA
Aldosterone results in increased expression of NR3C2 mRNA; Aldosterone results in increased expression of NR3C2 protein
Aldosterone inhibits the reaction [TSG101 protein binds to NR3C2 protein]; FR 180204 inhibits the reaction [Aldosterone results in increased phosphorylation of NR3C2 protein]
Aldosterone results in decreased expression of NR3C2 protein		 CTD PMID:7954537 PMID:8798622 PMID:8969928 PMID:15362971 PMID:15780662 More... NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885 		JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 multiple interactions
increases expression		 ISO Spironolactone inhibits the reaction [Aldosterone results in increased expression of OLR1 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of OLR1 protein]
Aldosterone results in increased expression of OLR1 mRNA; Aldosterone results in increased expression of OLR1 protein		 CTD PMID:20508287 NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523 		JBrowse link
G Plat plasminogen activator, tissue type multiple interactions EXP [Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of PLAT mRNA CTD PMID:27773435 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Plg plasminogen multiple interactions EXP [Aldosterone co-treated with Sodium Chloride, Dietary] results in increased activity of PLG protein modified form CTD PMID:27773435 NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786 		JBrowse link
G Pomc proopiomelanocortin multiple interactions
decreases abundance
increases abundance
increases secretion		 ISO
EXP		 Dexamethasone inhibits the reaction [POMC protein results in increased abundance of Aldosterone]
POMC protein results in decreased abundance of Aldosterone
POMC results in increased secretion of Aldosterone		 CTD PMID:1659878 PMID:2551692 PMID:3015796 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects abundance ISO PPARG protein affects the abundance of Aldosterone CTD PMID:16007095 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression EXP Aldosterone results in increased expression of PPARGC1A mRNA CTD PMID:19808358 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases activity
multiple interactions		 EXP Aldosterone results in increased activity of RELA protein
Bezafibrate inhibits the reaction [Aldosterone results in increased activity of RELA protein]; pioglitazone inhibits the reaction [Aldosterone results in increased activity of RELA protein]; prolinedithiocarbamate inhibits the reaction [Aldosterone results in increased activity of RELA protein]; SN50 peptide inhibits the reaction [Aldosterone results in increased activity of RELA protein]		 CTD PMID:18660453 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ren renin multiple interactions ISO [AGT co-treated with REN] results in increased abundance of Aldosterone; candesartan inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]; Enalapril inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone] CTD PMID:18679781 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha increases expression
affects expression
multiple interactions		 ISO Aldosterone results in increased expression of SCNN1A mRNA; Aldosterone results in increased expression of SCNN1A protein
Aldosterone affects the expression of SCNN1A mRNA
Aldosterone inhibits the reaction [NEDD4L gene mutant form results in decreased cleavage of SCNN1A protein]		 CTD PMID:16555725 PMID:18665318 PMID:23348737 NCBI chr 4:158,122,962...158,146,184
Ensembl chr 4:158,122,962...158,146,181 		JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta increases expression ISO Aldosterone results in increased expression of SCNN1B mRNA; Aldosterone results in increased expression of SCNN1B protein CTD PMID:18665318 NCBI chr 1:176,430,063...176,484,451
Ensembl chr 1:176,430,103...176,484,451 		JBrowse link
G Scnn1g sodium channel epithelial 1 subunit gamma increases expression ISO Aldosterone results in increased expression of SCNN1G mRNA; Aldosterone results in increased expression of SCNN1G protein CTD PMID:18665318 NCBI chr 1:176,304,942...176,338,816
Ensembl chr 1:176,304,942...176,338,816 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions
increases expression		 EXP
ISO		 [Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA; [Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein; [Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of SERPINE1 mRNA; [Eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; [Eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]; Eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; Eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]
Aldosterone results in increased expression of SERPINE1 mRNA		 CTD PMID:18682491 PMID:27773435 PMID:30809271 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 multiple interactions
increases expression
decreases expression		 EXP
ISO		 Spironolactone inhibits the reaction [Aldosterone results in increased expression of SGK1 mRNA]
TSG101 mutant form inhibits the reaction [Aldosterone results in decreased expression of SGK1 protein]		 CTD PMID:15130897 PMID:19429930 PMID:22798426 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283 		JBrowse link
G Slc12a2 solute carrier family 12 member 2 multiple interactions EXP Spironolactone inhibits the reaction [Aldosterone results in increased activity of SLC12A2 protein] CTD PMID:12668585 NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440 		JBrowse link
G Slc30a1 solute carrier family 30 member 1 multiple interactions
increases expression		 EXP Spironolactone inhibits the reaction [Aldosterone results in increased expression of SLC30A1 mRNA] CTD PMID:19333130 NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910 		JBrowse link
G Slc39a1 solute carrier family 39 member 1 multiple interactions
increases expression		 EXP Spironolactone inhibits the reaction [Aldosterone results in increased expression of SLC39A1 mRNA] CTD PMID:19333130 NCBI chr 2:175,703,413...175,709,063
Ensembl chr 2:175,703,441...175,709,058 		JBrowse link
G Slc9a1 solute carrier family 9 member A1 increases expression
multiple interactions		 EXP Aldosterone results in increased expression of SLC9A1 mRNA
eplerenone inhibits the reaction [Aldosterone results in increased expression of SLC9A1 mRNA]		 CTD PMID:16373419 NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624 		JBrowse link
G Slc9a3 solute carrier family 9 member A3 multiple interactions
increases abundance		 ISO AGT protein affects the reaction [SLC9A3 gene mutant form results in increased abundance of Aldosterone] CTD PMID:26564064 NCBI chr 1:29,124,633...29,167,912
Ensembl chr 1:29,124,674...29,167,417 		JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA]; eplerenone inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA]; Rotenone inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA]; U 0126 inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA] CTD PMID:17596522 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases activity		 EXP [Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in decreased activity of SOD1 protein; [Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased activity of SOD1 protein; Amlodipine inhibits the reaction [Aldosterone results in increased activity of SOD1 protein]; Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in decreased activity of SOD1 protein]; Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased activity of SOD1 protein]; Spironolactone inhibits the reaction [Aldosterone results in increased activity of SOD1 protein] CTD PMID:17616752 PMID:19333130 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Tat tyrosine aminotransferase multiple interactions EXP Aldosterone promotes the reaction [[NR3C1 protein binds to TAT promoter] which results in increased expression of TAT mRNA] CTD PMID:22465009 NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases secretion
increases expression
multiple interactions		 EXP Aldosterone results in increased secretion of TGFB1 protein
Aldosterone results in increased expression of TGFB1 mRNA
[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein; [Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TGFB1 mRNA; [Eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; [Eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]; Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; Enalapril inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]; Eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TGFB1 mRNA]; Eplerenone inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of TGFB1 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased secretion of TGFB1 protein]; tempol inhibits the reaction [Aldosterone results in increased expression of TGFB1 mRNA]		 CTD PMID:15130897 PMID:18682491 PMID:25204689 PMID:27773435 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TNF mRNA; Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TNF mRNA] CTD PMID:27773435 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 increases expression ISO Aldosterone results in increased expression of TRPM4 protein CTD PMID:28214884 NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532 		JBrowse link
G Tsg101 tumor susceptibility 101 multiple interactions ISO Aldosterone inhibits the reaction [TSG101 protein binds to NR3C2 protein]; TSG101 mutant form inhibits the reaction [Aldosterone results in decreased expression of SGK1 protein] CTD PMID:22798426 NCBI chr 1:97,412,689...97,442,589
Ensembl chr 1:97,410,848...97,442,554 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions
increases glucuronidation		 ISO alclofenac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; cicloprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Diclofenac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Diflunisal inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Fenoprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Ibuprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Indomethacin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Ketoprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Ketorolac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Meclofenamic Acid inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Mefenamic Acid inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; Naproxen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; pirprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]; tiaprofenic acid inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone] CTD PMID:19740398 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19900
    chemical entity 19898
      group 19856
        organic group 18957
          3-oxo-Delta(4)-steroid group 9168
            3-oxo-Delta(4) steroid 9168
              aldosterone 76
                5alpha-dihydroaldosterone 0
                5beta-dihydroaldosterone 0
                aldosterone hemiacetal 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19900
    subatomic particle 19898
      composite particle 19898
        hadron 19898
          baryon 19898
            nucleon 19898
              atomic nucleus 19898
                atom 19898
                  main group element atom 19845
                    p-block element atom 19845
                      carbon group element atom 19792
                        carbon atom 19787
                          organic molecular entity 19787
                            organic group 18957
                              organic divalent group 18938
                                organodiyl group 18938
                                  carbonyl group 18890
                                    carbonyl compound 18890
                                      carboxylic acid 18611
                                        carboacyl group 17702
                                          univalent carboacyl group 17702
                                            formyl group 8954
                                              aldehyde 8954
                                                steroid aldehyde 91
                                                  aldosterone 76
                                                    5alpha-dihydroaldosterone 0
                                                    5beta-dihydroaldosterone 0
                                                    aldosterone hemiacetal 0
paths to the root