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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phosphoramidate ester
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Accession:CHEBI:27577 term browser browse the term
Definition:A phosphoric ester (phosphate) that has an NR2 instead of an OH group.
Synonyms:related_synonym: Phosphoamide;   phosphoramidate esters
 alt_id: CHEBI:26050;   CHEBI:37718;   CHEBI:8144
 xref: KEGG:C01976


show annotations for term's descendants           Sort by:
 
fenamiphos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity
multiple interactions
ISO fenamiphos results in decreased activity of ACHE protein
fenamiphos binds to and results in increased phosphorylation of and results in decreased activity of ACHE protein
CTD PMID:17382909, PMID:17402711 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
affects activity
ISO fenamiphos binds to and results in increased activity of NR1I2 protein
fenamiphos affects the activity of NR1I2 protein
CTD PMID:21115097, PMID:23611293 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
propetamphos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity
multiple interactions
ISO
EXP
propetamphos results in decreased activity of CAT protein
[cypermethrin co-treated with propetamphos] results in decreased activity of CAT protein
[propetamphos co-treated with cypermethrin] results in decreased activity of CAT protein
CTD PMID:18214882, PMID:25926273 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cycs cytochrome c, somatic multiple interactions
increases activity
EXP [propetamphos co-treated with cypermethrin] results in increased activity of CYCS protein
propetamphos results in increased activity of CYCS protein
CTD PMID:25926273 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases activity
EXP [cypermethrin co-treated with propetamphos] results in increased activity of CYP2E1 protein
propetamphos results in increased activity of CYP2E1 protein
CTD PMID:25926273 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions
decreases activity
EXP [cypermethrin co-treated with propetamphos] results in decreased activity of G6PD protein
propetamphos results in decreased activity of G6PD protein
CTD PMID:25926273 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
remdesivir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Remdesivir decreases expression of CCL2 mRNA and protein in SARS-CoV-2 induced hepatocellular carcinoma cells RGD PMID:32360580 RGD:30309211 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression ISO Remdesivir decreases expression of CXCL10 mRNA and protein in SARS-CoV-2 induced hepatocellular carcinoma cells RGD PMID:32360580 RGD:30309211 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO Remdesivir decreases expression of IL1B mRNA and protein in SARS-CoV-2 induced hepatocellular carcinoma cells RGD PMID:32360580 RGD:30309211 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 decreases expression ISO Remdesivir decreases expression of IL-6 mRNA and protein in SARS-CoV-2 induced hepatocellular carcinoma cells RGD PMID:32360580 RGD:30309211 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO Remdesivir decreases expression of TNF mRNA and protein in SARS-CoV-2 induced hepatocellular carcinoma cells RGD PMID:32360580 RGD:30309211 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        solvent 16456
          phosphoric acid 7794
            phosphoramide 1006
              phosphoramidate ester 11
                2'-deoxy-5'-O-[(R)-hydroxy(phosphonoamino)phosphoryl]uridine 0
                O-ethyl O-(5-methyl-4-nitrophenyl) N-(1-methylpropyl)phosphoramidothioate 0
                agrocin 84 0
                ethoxy(isopropylamino)phosphinate 0
                fenamiphos 2
                propetamphos 4
                remdesivir 5
                sofosbuvir + 0
                tenofovir alafenamide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      chalcogen 19360
                        oxygen atom 19321
                          oxygen molecular entity 19321
                            hydroxides 19066
                              oxoacid 18192
                                pnictogen oxoacid 10144
                                  phosphorus oxoacid 9032
                                    phosphoric acids 7794
                                      phosphoric acid 7794
                                        phosphoric acid derivative 7473
                                          phosphoric ester 7472
                                            phosphoramidate ester 11
                                              2'-deoxy-5'-O-[(R)-hydroxy(phosphonoamino)phosphoryl]uridine 0
                                              O-ethyl O-(5-methyl-4-nitrophenyl) N-(1-methylpropyl)phosphoramidothioate 0
                                              agrocin 84 0
                                              ethoxy(isopropylamino)phosphinate 0
                                              fenamiphos 2
                                              propetamphos 4
                                              remdesivir 5
                                              sofosbuvir + 0
                                              tenofovir alafenamide 0
paths to the root

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