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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phosphoramidate ester
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Accession:CHEBI:27577 term browser browse the term
Definition:A phosphoric ester (phosphate) that has an NR2 instead of an OH group.
Synonyms:related_synonym: Phosphoamide;   phosphoramidate esters
 alt_id: CHEBI:26050;   CHEBI:37718;   CHEBI:8144
 xref: KEGG:C01976



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fenamiphos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity
multiple interactions
ISO
EXP
fenamiphos results in decreased activity of ACHE protein
fenamiphos binds to and results in increased phosphorylation of and results in decreased activity of ACHE protein
CTD PMID:17382909 PMID:17402711 PMID:33720374 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Ar androgen receptor multiple interactions ISO fenamiphos inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein] CTD PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO fenamiphos binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO fenamiphos binds to and results in increased activity of ESR2 protein CTD PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
affects activity
ISO fenamiphos binds to and results in increased activity of NR1I2 protein
fenamiphos affects the activity of NR1I2 protein
CTD PMID:21115097 PMID:23611293 PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO fenamiphos binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Tp53 tumor protein p53 affects activity ISO fenamiphos metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
propetamphos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity
multiple interactions
ISO
EXP
propetamphos results in decreased activity of CAT protein
[propetamphos co-treated with cypermethrin] results in decreased activity of CAT protein
[cypermethrin co-treated with propetamphos] results in decreased activity of CAT protein
CTD PMID:18214882 PMID:25926273 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cycs cytochrome c, somatic multiple interactions
increases activity
EXP [propetamphos co-treated with cypermethrin] results in increased activity of CYCS protein
propetamphos results in increased activity of CYCS protein
CTD PMID:25926273 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases activity
EXP [cypermethrin co-treated with propetamphos] results in increased activity of CYP2E1 protein
propetamphos results in increased activity of CYP2E1 protein
CTD PMID:25926273 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions
decreases activity
EXP [cypermethrin co-treated with propetamphos] results in decreased activity of G6PD protein
propetamphos results in decreased activity of G6PD protein
CTD PMID:25926273 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Tp53 tumor protein p53 affects activity ISO propetamphos metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
remdesivir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase increases hydrolysis ISO ACHE protein results in increased hydrolysis of remdesivir CTD PMID:34774545 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Atm ATM serine/threonine kinase increases phosphorylation ISO remdesivir results in increased phosphorylation of ATM protein CTD PMID:35417658 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO remdesivir results in increased expression of BAX protein CTD PMID:35417658 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bche butyrylcholinesterase increases hydrolysis ISO BCHE protein results in increased hydrolysis of remdesivir CTD PMID:34774545 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO remdesivir results in decreased expression of BCL2 protein CTD PMID:35417658 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l11 Bcl2-like 11 increases expression ISO remdesivir results in increased expression of BCL2L11 protein CTD PMID:35417658 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Casp3 caspase 3 decreases expression ISO remdesivir results in decreased expression of CASP3 protein CTD PMID:35417658 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 decreases expression ISO remdesivir results in decreased expression of CASP7 protein CTD PMID:35417658 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Remdesivir decreases expression of CCL2 mRNA and protein in SARS-CoV-2 induced hepatocellular carcinoma cells RGD PMID:32360580 RGD:30309211 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cdx2 caudal type homeo box 2 increases expression ISO remdesivir results in increased expression of CDX2 mRNA CTD PMID:35605700 NCBI chr12:7,726,798...7,733,142
Ensembl chr12:7,726,798...7,733,142
JBrowse link
G Ces1d carboxylesterase 1D increases hydrolysis
multiple interactions
ISO CES1 protein results in increased hydrolysis of remdesivir
Simvastatin inhibits the reaction [CES1 protein results in increased hydrolysis of remdesivir]
CTD PMID:34774545 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
JBrowse link
G Ctsa cathepsin A increases hydrolysis ISO CTSA protein results in increased hydrolysis of remdesivir CTD PMID:34774545 NCBI chr 3:153,569,106...153,574,983
Ensembl chr 3:153,568,381...153,576,215
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression ISO Remdesivir decreases expression of CXCL10 mRNA and protein in SARS-CoV-2 induced hepatocellular carcinoma cells RGD PMID:32360580 RGD:30309211 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Esrrb estrogen-related receptor beta decreases expression ISO remdesivir results in decreased expression of ESRRB mRNA CTD PMID:35605700 NCBI chr 6:106,007,662...106,163,136
Ensembl chr 6:106,008,095...106,160,791
JBrowse link
G Foxo3 forkhead box O3 increases expression ISO remdesivir results in increased expression of FOXO3 protein CTD PMID:35417658 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Gata3 GATA binding protein 3 increases expression ISO remdesivir results in increased expression of GATA3 mRNA CTD PMID:35605700 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
JBrowse link
G Gata4 GATA binding protein 4 decreases expression ISO remdesivir results in decreased expression of GATA4 mRNA CTD PMID:35605700 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636
JBrowse link
G H2ax H2A.X variant histone increases expression ISO remdesivir results in increased expression of H2AX protein CTD PMID:35417658 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO Remdesivir decreases expression of IL1B mRNA and protein in SARS-CoV-2 induced hepatocellular carcinoma cells RGD PMID:32360580 RGD:30309211 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 decreases expression ISO Remdesivir decreases expression of IL-6 mRNA and protein in SARS-CoV-2 induced hepatocellular carcinoma cells RGD PMID:32360580 RGD:30309211 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO remdesivir results in decreased expression of MKI67 protein CTD PMID:35417658 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Nanog Nanog homeobox decreases expression ISO remdesivir results in decreased expression of NANOG mRNA CTD PMID:35605700 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression ISO remdesivir results in increased expression of PARP1 protein CTD PMID:35417658 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pdgfra platelet derived growth factor receptor alpha decreases expression ISO remdesivir results in decreased expression of PDGFRA mRNA CTD PMID:35605700 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335
JBrowse link
G Sox17 SRY-box transcription factor 17 decreases expression ISO remdesivir results in decreased expression of SOX17 mRNA CTD PMID:35605700 NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228
JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression ISO remdesivir results in decreased expression of SOX2 mRNA CTD PMID:35605700 NCBI chr 2:117,536,929...117,539,338
Ensembl chr 2:117,536,929...117,539,338
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO Remdesivir decreases expression of TNF mRNA and protein in SARS-CoV-2 induced hepatocellular carcinoma cells RGD PMID:32360580 RGD:30309211 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
sofosbuvir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Klrc1 killer cell lectin like receptor C1 decreases expression ISO sofosbuvir co-treated with ledipasvir decreased expression of NCR1 protein in natural killer cells RGD PMID:31218578 RGD:40400920 NCBI chr 4:163,142,142...163,152,425
Ensembl chr 4:163,147,189...163,152,425
JBrowse link
G Ncr1 natural cytotoxicity triggering receptor 1 affects expression ISO sofosbuvir co-treated with ledipasvir affects expression of NCR1 protein in natural killer cells RGD PMID:31218578 RGD:40400920 NCBI chr 1:69,614,744...69,622,570 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19751
    role 19724
      application 19557
        solvent 16713
          phosphoric acid 9753
            phosphoramide 1045
              phosphoramidate ester 39
                2'-deoxy-5'-O-[(R)-hydroxy(phosphonoamino)phosphoryl]uridine 0
                O-ethyl O-(5-methyl-4-nitrophenyl) N-(1-methylpropyl)phosphoramidothioate 0
                agrocin 84 0
                ethoxy(isopropylamino)phosphinate 0
                fenamiphos 7
                propetamphos 5
                remdesivir 27
                sofosbuvir + 2
                tenofovir alafenamide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19751
    subatomic particle 19749
      composite particle 19749
        hadron 19749
          baryon 19749
            nucleon 19749
              atomic nucleus 19749
                atom 19749
                  main group element atom 19698
                    p-block element atom 19698
                      chalcogen 19492
                        oxygen atom 19469
                          oxygen molecular entity 19469
                            hydroxides 19267
                              oxoacid 18632
                                pnictogen oxoacid 11787
                                  phosphorus oxoacid 10769
                                    phosphoric acids 9753
                                      phosphoric acid 9753
                                        phosphoric acid derivative 9497
                                          phosphoric ester 9496
                                            phosphoramidate ester 39
                                              2'-deoxy-5'-O-[(R)-hydroxy(phosphonoamino)phosphoryl]uridine 0
                                              O-ethyl O-(5-methyl-4-nitrophenyl) N-(1-methylpropyl)phosphoramidothioate 0
                                              agrocin 84 0
                                              ethoxy(isopropylamino)phosphinate 0
                                              fenamiphos 7
                                              propetamphos 5
                                              remdesivir 27
                                              sofosbuvir + 2
                                              tenofovir alafenamide 0
paths to the root