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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-aminosalicylic acid
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Accession:CHEBI:27565 term browser browse the term
Definition:An aminobenzoic acid that is salicylic acid substituted by an amino group at position 4.
Synonyms:exact_synonym: 4-amino-2-hydroxybenzoic acid
 related_synonym: 2-HYDROXY-4-AMINOBENZOIC ACID;   4-Aminosalicylate;   Aminosalicylic acid;   Formula=C7H7NO3;   InChI=1S/C7H7NO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,8H2,(H,10,11);   InChIKey=WUBBRNOQWQTFEX-UHFFFAOYSA-N;   PAS;   Para-amino salicylic acid;   Paser;   SMILES=Nc1ccc(C(O)=O)c(O)c1;   p-aminosalicylic acid
 alt_id: CHEBI:1789;   CHEBI:20320;   CHEBI:41152
 xref: Beilstein:473071;   CAS:65-49-6;   DrugBank:DB00233;   Drug_Central:2050;   Gmelin:306153;   HMDB:HMDB0014378;   KEGG:C02518;   KEGG:D00162;   LINCS:LSM-5862
 xref_mesh: MESH:D010131
 xref: PDBeChem:BHA;   PMID:11621575;   PMID:1650428;   PMID:23118010;   PMID:24663015;   PMID:25050392;   PMID:25421465;   PMID:25605031;   PMID:25963985;   PMID:26004847;   PMID:26033719;   PMID:26277036;   PMID:26596566;   PMID:26848874;   PMID:27021327;   PMID:27491492;   PMID:27617928;   PMID:27671064;   PMID:28011126;   PMID:28223391;   PMID:28394286;   PMID:28408267;   PMID:28567674;   PMID:28651968;   PMID:28717039;   PMID:28812999;   Patent:DE50835;   Patent:US2844625;   Patent:US427564;   Reaxys:473071;   Wikipedia:Aminosalicylic_Acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:137598


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4-aminosalicylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP6 bone morphogenetic protein 6 increases expression EXP Aminosalicylic Acid results in increased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr 6:7,726,099...7,881,728
Ensembl chr 6:7,726,099...7,881,728 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression EXP Aminosalicylic Acid results in increased expression of CXCL8 mRNA CTD PMID:32816093 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G EREG epiregulin increases expression EXP Aminosalicylic Acid results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr 4:74,365,145...74,388,749
Ensembl chr 4:74,365,145...74,388,749 		JBrowse link
G IL24 interleukin 24 increases expression EXP Aminosalicylic Acid results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr 1:206,897,443...206,904,139
Ensembl chr 1:206,897,443...206,904,139 		JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase increases expression EXP Aminosalicylic Acid results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 7:116,672,196...116,798,377
Ensembl chr 7:116,672,196...116,798,377 		JBrowse link
G NAT1 N-acetyltransferase 1 increases acetylation EXP NAT1 protein results in increased acetylation of Aminosalicylic Acid CTD PMID:15627487 PMID:16003948 NCBI chr 8:18,170,467...18,223,689
Ensembl chr 8:18,170,477...18,223,689 		JBrowse link
G NAT2 N-acetyltransferase 2 multiple interactions ISO [Peroxynitrous Acid results in decreased activity of NAT2 protein] which results in decreased acetylation of Aminosalicylic Acid CTD PMID:19248797 NCBI chr 8:18,386,301...18,401,218
Ensembl chr 8:18,391,282...18,401,218 		JBrowse link
G PID1 phosphotyrosine interaction domain containing 1 increases expression EXP Aminosalicylic Acid results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 2:229,023,973...229,271,287
Ensembl chr 2:228,850,526...229,271,287 		JBrowse link
G SLC7A11 solute carrier family 7 member 11 increases expression EXP Aminosalicylic Acid results in increased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349 		JBrowse link
G SLPI secretory leukocyte peptidase inhibitor increases expression EXP Aminosalicylic Acid results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr20:45,252,239...45,254,564
Ensembl chr20:45,252,239...45,254,564 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      biological role 25929
        antimicrobial agent 21890
          antifungal agent 19697
            salicylic acid 1622
              4-aminosalicylic acid 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      carbon group element atom 25434
                        carbon atom 25403
                          organic molecular entity 25392
                            heteroorganic entity 24766
                              organochalcogen compound 24378
                                organooxygen compound 24054
                                  carbon oxoacid 22749
                                    carboxylic acid 22729
                                      aromatic carboxylic acid 13362
                                        benzoic acids 13353
                                          benzoic acid 5808
                                            hydroxybenzoic acid 5212
                                              monohydroxybenzoic acid 2913
                                                salicylic acid 1622
                                                  4-aminosalicylic acid 10
paths to the root