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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-aminosalicylic acid
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Accession:CHEBI:27565 term browser browse the term
Definition:An aminobenzoic acid that is salicylic acid substituted by an amino group at position 4.
Synonyms:exact_synonym: 4-amino-2-hydroxybenzoic acid
 related_synonym: 2-HYDROXY-4-AMINOBENZOIC ACID;   4-Aminosalicylate;   Aminosalicylic acid;   Formula=C7H7NO3;   InChI=1S/C7H7NO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,8H2,(H,10,11);   InChIKey=WUBBRNOQWQTFEX-UHFFFAOYSA-N;   PAS;   Para-amino salicylic acid;   Paser;   SMILES=Nc1ccc(C(O)=O)c(O)c1;   p-aminosalicylic acid
 alt_id: CHEBI:1789;   CHEBI:20320;   CHEBI:41152
 xref: Beilstein:473071;   CAS:65-49-6;   DrugBank:DB00233;   Drug_Central:2050;   Gmelin:306153;   HMDB:HMDB0014378;   KEGG:C02518;   KEGG:D00162;   LINCS:LSM-5862
 xref_mesh: MESH:D010131
 xref: PDBeChem:BHA;   PMID:11621575;   PMID:1650428;   PMID:23118010;   PMID:24663015;   PMID:25050392;   PMID:25421465;   PMID:25605031;   PMID:25963985;   PMID:26004847;   PMID:26033719;   PMID:26277036;   PMID:26596566;   PMID:26848874;   PMID:27021327;   PMID:27491492;   PMID:27617928;   PMID:27671064;   PMID:28011126;   PMID:28223391;   PMID:28394286;   PMID:28408267;   PMID:28567674;   PMID:28651968;   PMID:28717039;   PMID:28812999;   Patent:DE50835;   Patent:US2844625;   Patent:US427564;   Reaxys:473071;   Wikipedia:Aminosalicylic_Acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:137598


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4-aminosalicylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp6 bone morphogenetic protein 6 increases expression ISO Aminosalicylic Acid results in increased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr17:26,318,121...26,469,034
Ensembl chr17:26,318,569...26,470,365
JBrowse link
G Ereg epiregulin increases expression ISO Aminosalicylic Acid results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
JBrowse link
G Il24 interleukin 24 increases expression ISO Aminosalicylic Acid results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO Aminosalicylic Acid results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Nat1 N-acetyltransferase 1 increases acetylation ISO NAT1 protein results in increased acetylation of Aminosalicylic Acid CTD PMID:15627487 PMID:16003948 NCBI chr16:22,218,217...22,238,516 JBrowse link
G Nat2 N-acetyltransferase 2 multiple interactions ISO [Peroxynitrous Acid results in decreased activity of NAT2 protein] which results in decreased acetylation of Aminosalicylic Acid CTD PMID:19248797 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Aminosalicylic Acid results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Aminosalicylic Acid results in increased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Aminosalicylic Acid results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        antimicrobial agent 17408
          antifungal agent 15099
            salicylic acid 769
              4-aminosalicylic acid 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        aromatic carboxylic acid 11710
                                          benzoic acids 11683
                                            benzoic acid 4156
                                              hydroxybenzoic acid 3560
                                                monohydroxybenzoic acid 1289
                                                  salicylic acid 769
                                                    4-aminosalicylic acid 9
paths to the root