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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5-methylcytosine
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Accession:CHEBI:27551 term browser browse the term
Definition:A pyrimidine that is a derivative of cytosine, having a methyl group at the 5-position.
Synonyms:exact_synonym: 4-amino-5-methylpyrimidin-2(1H)-one
 related_synonym: 4-Amino-5-methyl-2-pyrimidinol;   4-amino-5-methyl-2(1H)-pyrimidinone;   Formula=C5H7N3O;   InChI=1S/C5H7N3O/c1-3-2-7-5(9)8-4(3)6/h2H,1H3,(H3,6,7,8,9);   InChIKey=LRSASMSXMSNRBT-UHFFFAOYSA-N;   SMILES=Cc1c[nH]c(=O)nc1N
 alt_id: CHEBI:20608;   CHEBI:2094;   CHEBI:85013
 xref: Beilstein:120387;   CAS:554-01-8;   KEGG:C02376
 xref_mesh: MESH:D044503
 xref: MetaCyc:CPD0-2018;   PMID:17325422;   PMID:22770225;   PMID:25304211;   PMID:25421665;   PMID:25510268;   PMID:25510270;   PMID:25522353;   PMID:25620416;   PMID:25675106;   Reaxys:508871;   Wikipedia:5-Methylcytosine


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5-methylcytosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [hydroquinone affects the methylation of GCLC promoter] which results in decreased abundance of 5-Methylcytosine CTD PMID:23940045 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Sfn stratifin multiple interactions ISO [hydroquinone affects the methylation of SFN promoter] which results in decreased abundance of 5-Methylcytosine CTD PMID:23940045 NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314 		JBrowse link
G Tet1 tet methylcytosine dioxygenase 1 multiple interactions ISO TET1 protein affects the reaction [2,3,5,6-tetrachlorohydroquinone results in increased oxidation of 5-Methylcytosine]; TET1 protein affects the reaction [Chloranil results in increased oxidation of 5-Methylcytosine] CTD PMID:24214992 NCBI chr20:25,761,042...25,840,926
Ensembl chr20:25,768,120...25,833,052 		JBrowse link
G Tet2 tet methylcytosine dioxygenase 2 multiple interactions ISO TET2 protein affects the reaction [2,3,5,6-tetrachlorohydroquinone results in increased oxidation of 5-Methylcytosine]; TET2 protein affects the reaction [Chloranil results in increased oxidation of 5-Methylcytosine] CTD PMID:24214992 NCBI chr 2:221,988,645...222,072,813
Ensembl chr 2:221,988,645...222,072,534 		JBrowse link
G Wrap53 WD repeat containing, antisense to TP53 multiple interactions ISO [Pesticides results in increased methylation of WRAP53 gene] which results in increased abundance of 5-Methylcytosine CTD PMID:31243981 NCBI chr10:54,282,092...54,299,908
Ensembl chr10:54,282,105...54,298,929 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      application 19630
        NMR chemical shift reference compound 17936
          ammonia 17795
            organic amino compound 17795
              aromatic amine 15398
                aminopyrimidine 1927
                  methylcytosine 5
                    5-methylcytosine 5
                      5-methylcytosin-1-yl group 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    main group molecular entity 19759
                      s-block molecular entity 19628
                        hydrogen molecular entity 19614
                          hydrides 19087
                            inorganic hydride 18091
                              pnictogen hydride 18080
                                nitrogen hydride 17987
                                  azane 17796
                                    ammonia 17795
                                      organic amino compound 17795
                                        aromatic amine 15398
                                          aminopyrimidine 1927
                                            cytosine 1371
                                              methylcytosine 5
                                                5-methylcytosine 5
                                                  5-methylcytosin-1-yl group 0
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