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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:5-methylcytosine
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Accession:CHEBI:27551 term browser browse the term
Definition:A pyrimidine that is a derivative of cytosine, having a methyl group at the 5-position.
Synonyms:exact_synonym: 4-amino-5-methylpyrimidin-2(1H)-one
 related_synonym: 4-Amino-5-methyl-2-pyrimidinol;   4-amino-5-methyl-2(1H)-pyrimidinone;   Formula=C5H7N3O;   InChI=1S/C5H7N3O/c1-3-2-7-5(9)8-4(3)6/h2H,1H3,(H3,6,7,8,9);   InChIKey=LRSASMSXMSNRBT-UHFFFAOYSA-N;   SMILES=Cc1c[nH]c(=O)nc1N
 alt_id: CHEBI:20608;   CHEBI:2094;   CHEBI:85013
 xref: Beilstein:120387;   CAS:554-01-8;   KEGG:C02376
 xref_mesh: MESH:D044503
 xref: MetaCyc:CPD0-2018;   PMID:17325422;   PMID:22770225;   PMID:25304211;   PMID:25421665;   PMID:25510268;   PMID:25510270;   PMID:25522353;   PMID:25620416;   PMID:25675106;   Reaxys:508871;   Wikipedia:5-Methylcytosine


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5-methylcytosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tet1 tet methylcytosine dioxygenase 1 multiple interactions ISO TET1 protein affects the reaction [2,3,5,6-tetrachlorohydroquinone results in increased oxidation of 5-Methylcytosine]; TET1 protein affects the reaction [Chloranil results in increased oxidation of 5-Methylcytosine] CTD PMID:24214992 NCBI chr20:27,359,122...27,438,039
Ensembl chr20:27,366,213...27,437,427
JBrowse link
G Tet2 tet methylcytosine dioxygenase 2 multiple interactions ISO TET2 protein affects the reaction [2,3,5,6-tetrachlorohydroquinone results in increased oxidation of 5-Methylcytosine]; TET2 protein affects the reaction [Chloranil results in increased oxidation of 5-Methylcytosine] CTD PMID:24214992 NCBI chr 2:238,719,389...238,802,975
Ensembl chr 2:238,720,835...238,803,024
JBrowse link
G Wrap53 WD repeat containing, antisense to TP53 multiple interactions ISO [Pesticides results in increased methylation of WRAP53 gene] which results in increased abundance of 5-Methylcytosine CTD PMID:31243981 NCBI chr10:56,169,024...56,185,800
Ensembl chr10:56,169,025...56,185,857
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    role 19804
      application 19477
        refrigerant 17487
          ammonia 17014
            organic amino compound 17013
              aromatic amine 13674
                aminopyrimidine 1282
                  methylcytosine 3
                    5-methylcytosine 3
                      5-methylcytosin-1-yl group 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    main group molecular entity 19744
                      s-block molecular entity 19491
                        hydrogen molecular entity 19483
                          hydrides 18748
                            inorganic hydride 17481
                              pnictogen hydride 17454
                                nitrogen hydride 17296
                                  azane 17015
                                    ammonia 17014
                                      organic amino compound 17013
                                        aromatic amine 13674
                                          aminopyrimidine 1282
                                            cytosine 1117
                                              methylcytosine 3
                                                5-methylcytosine 3
                                                  5-methylcytosin-1-yl group 0
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