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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:5-methylcytosine
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Accession:CHEBI:27551 term browser browse the term
Definition:A pyrimidine that is a derivative of cytosine, having a methyl group at the 5-position.
Synonyms:exact_synonym: 4-amino-5-methylpyrimidin-2(1H)-one
 related_synonym: 4-Amino-5-methyl-2-pyrimidinol;   4-amino-5-methyl-2(1H)-pyrimidinone;   Formula=C5H7N3O;   InChI=1S/C5H7N3O/c1-3-2-7-5(9)8-4(3)6/h2H,1H3,(H3,6,7,8,9);   InChIKey=LRSASMSXMSNRBT-UHFFFAOYSA-N;   SMILES=Cc1c[nH]c(=O)nc1N
 alt_id: CHEBI:20608;   CHEBI:2094;   CHEBI:85013
 xref: Beilstein:120387;   CAS:554-01-8;   KEGG:C02376
 xref_mesh: MESH:D044503
 xref: MetaCyc:CPD0-2018;   PMID:17325422;   PMID:22770225;   PMID:25304211;   PMID:25421665;   PMID:25510268;   PMID:25510270;   PMID:25522353;   PMID:25620416;   PMID:25675106;   Reaxys:508871;   Wikipedia:5-Methylcytosine



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5-methylcytosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tet1 tet methylcytosine dioxygenase 1 multiple interactions ISO TET1 protein affects the reaction [2,3,5,6-tetrachlorohydroquinone results in increased oxidation of 5-Methylcytosine]; TET1 protein affects the reaction [Chloranil results in increased oxidation of 5-Methylcytosine] CTD PMID:24214992 NCBI chr20:25,761,042...25,840,926
Ensembl chr20:25,768,120...25,833,052
JBrowse link
G Tet2 tet methylcytosine dioxygenase 2 multiple interactions ISO TET2 protein affects the reaction [2,3,5,6-tetrachlorohydroquinone results in increased oxidation of 5-Methylcytosine]; TET2 protein affects the reaction [Chloranil results in increased oxidation of 5-Methylcytosine] CTD PMID:24214992 NCBI chr 2:221,988,645...222,072,813
Ensembl chr 2:221,988,645...222,072,534
JBrowse link
G Wrap53 WD repeat containing, antisense to TP53 multiple interactions ISO [Pesticides results in increased methylation of WRAP53 gene] which results in increased abundance of 5-Methylcytosine CTD PMID:31243981 NCBI chr10:54,282,092...54,299,908
Ensembl chr10:54,282,105...54,298,929
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      application 19498
        refrigerant 17688
          ammonia 17277
            organic amino compound 17277
              aromatic amine 13710
                aminopyrimidine 1599
                  methylcytosine 3
                    5-methylcytosine 3
                      5-methylcytosin-1-yl group 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    main group molecular entity 19698
                      s-block molecular entity 19479
                        hydrogen molecular entity 19471
                          hydrides 18834
                            inorganic hydride 17691
                              pnictogen hydride 17671
                                nitrogen hydride 17543
                                  azane 17278
                                    ammonia 17277
                                      organic amino compound 17277
                                        aromatic amine 13710
                                          aminopyrimidine 1599
                                            cytosine 1139
                                              methylcytosine 3
                                                5-methylcytosine 3
                                                  5-methylcytosin-1-yl group 0
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