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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:isatin
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Accession:CHEBI:27539 term browser browse the term
Definition:An indoledione that is the 2,3-diketo derivative of indole.
Synonyms:exact_synonym: 1H-indole-2,3-dione
 related_synonym: Formula=C8H5NO2;   InChI=1S/C8H5NO2/c10-7-5-3-1-2-4-6(5)9-8(7)11/h1-4H,(H,9,10,11);   InChIKey=JXDYKVIHCLTXOP-UHFFFAOYSA-N;   SMILES=O=C1Nc2ccccc2C1=O;   indole-2,3-dione
 alt_id: CHEBI:24879;   CHEBI:43625;   CHEBI:5978
 xref: Beilstein:383659;   CAS:91-56-5;   DrugBank:DB02095;   Gmelin:165206;   KEGG:C11129;   KNApSAcK:C00026981
 xref_mesh: MESH:D007510
 xref: MetaCyc:ISATIN;   PDBeChem:ISN;   PMID:15876476;   PMID:16236622;   PMID:1650428;   PMID:17330218;   PMID:17447419;   PMID:19834914;   PMID:23744416;   PMID:26846278;   PMID:9510091;   Reaxys:383659;   Wikipedia:Isatin



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isatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B1 increases reduction ISO AKR1B1 protein results in increased reduction of Isatin CTD PMID:10510318 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 multiple interactions EXP [AKR1B8 protein co-treated with NADP] affects the reduction of Isatin CTD PMID:18845131 NCBI chr 4:62,997,241...63,009,815
Ensembl chr 4:62,997,161...63,010,097
JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 affects reduction
increases reduction
ISO Isatin affects the reduction of AKR7A5 protein
AKR7A2 protein results in increased reduction of Isatin
CTD PMID:10510318 PMID:12604212 NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased cleavage of CASP3 protein; [Copper binds to Isatin binds to trimethylenediamine] which results in increased cleavage of CASP3 protein CTD PMID:17327230 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased cleavage of CASP9 protein; [Copper binds to Isatin binds to trimethylenediamine] which results in increased cleavage of CASP9 protein CTD PMID:17327230 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cbr3 carbonyl reductase 3 increases metabolic processing ISO CBR3 protein results in increased metabolism of Isatin CTD PMID:19061875 NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased expression of CDKN1A protein; [Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of CDKN1A protein; Tretinoin inhibits the reaction [[Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of CDKN1A protein] CTD PMID:17327230 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which affects the localization of CYCS protein; [Copper binds to Isatin binds to trimethylenediamine] which affects the localization of CYCS protein CTD PMID:17327230 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases expression ISO Isatin results in increased expression of CYP2D6 mRNA CTD PMID:15056799 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression ISO Isatin results in increased expression of CYP2E1 mRNA CTD PMID:15056799 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Dhrs11 dehydrogenase/reductase 11 increases reduction ISO DHRS11 protein results in increased reduction of Isatin CTD PMID:30926317 NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295
JBrowse link
G Dhrs7 dehydrogenase/reductase 7 increases reduction ISO DHRS7 protein results in increased reduction of Isatin CTD PMID:24246760 NCBI chr 6:91,332,259...91,347,856
Ensembl chr 6:91,251,323...91,347,892
JBrowse link
G Il10 interleukin 10 multiple interactions EXP Isatin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10] CTD PMID:24316276 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G LOC102556347 carbonyl reductase [NADPH] 1-like multiple interactions ISO [S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of Isatin] CTD PMID:23295225 NCBI chr11:32,892,640...32,895,277
Ensembl chr11:32,857,991...32,895,275
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Isatin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MPO] CTD PMID:24316276 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Isatin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2] CTD PMID:24316276 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO SOD1 protein results in decreased susceptibility to [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine]; SOD1 protein results in decreased susceptibility to [Copper binds to Isatin binds to trimethylenediamine] CTD PMID:17327230 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Isatin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF] CTD PMID:24316276 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased expression of TP53 protein; [Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of TP53 protein; Tretinoin inhibits the reaction [[Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of TP53 protein] CTD PMID:17327230 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        biochemical role 19671
          metabolite 19631
            eukaryotic metabolite 19358
              plant metabolite 17795
                isatin 19
                  1-methyl-5-(2-phenoxymethylpyrrolidine-1-sulfonyl)-1H-indole-2,3-dione 0
                  5-(6-aminohexanamido)isatin 0
                  5-aminoisatin 0
                  6-(3'-methylbuten-2-yl)isatin 0
                  N-acetylisatin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic molecule 19856
                              organic cyclic compound 19612
                                organic heterocyclic compound 18824
                                  organic heteropolycyclic compound 18298
                                    organic heterobicyclic compound 17170
                                      benzopyrrole 9625
                                        indoles 9296
                                          indolones 5914
                                            indoledione 19
                                              isatin 19
                                                1-methyl-5-(2-phenoxymethylpyrrolidine-1-sulfonyl)-1H-indole-2,3-dione 0
                                                5-(6-aminohexanamido)isatin 0
                                                5-aminoisatin 0
                                                6-(3'-methylbuten-2-yl)isatin 0
                                                N-acetylisatin 0
paths to the root