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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:umbelliferone
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Accession:CHEBI:27510 term browser browse the term
Definition:A hydroxycoumarin that is coumarin substituted by a hydroxy group ay position 7.
Synonyms:related_synonym: 7-Hydroxy-2H-chromen-2-one;   7-Hydroxycoumarin;   7-hydroxy-2H-1-benzopyran-2-one;   Formula=C9H6O3;   InChI=1S/C9H6O3/c10-7-3-1-6-2-4-9(11)12-8(6)5-7/h1-5,10H;   InChIKey=ORHBXUUXSCNDEV-UHFFFAOYSA-N;   SMILES=C12=CC(=CC=C2C=CC(O1)=O)O;   beta-umbelliferone;   hydrangin;   skimmetin
 alt_id: CHEBI:27187;   CHEBI:27188;   CHEBI:9858
 xref: Beilstein:127683;   CAS:93-35-6;   Gmelin:1220112;   KEGG:C09315;   KNApSAcK:C00002503;   LINCS:LSM-3960
 xref_mesh: MESH:C031477


show annotations for term's descendants           Sort by:
umbelliferone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2A19 cytochrome P450 family 2 subfamily A member 19 multiple interactions EXP 2-aminoacetophenone inhibits the reaction [[CYP2A19 protein results in increased hydroxylation of coumarin] which results in increased chemical synthesis of 7-hydroxycoumarin]; [CYP2A19 protein results in increased hydroxylation of coumarin] which results in increased chemical synthesis of 7-hydroxycoumarin; Skatole inhibits the reaction [[CYP2A19 protein results in increased hydroxylation of coumarin] which results in increased chemical synthesis of 7-hydroxycoumarin] CTD PMID:30599194 NCBI chr 6:49,056,579...49,064,111
Ensembl chr 6:49,056,578...49,064,107 		JBrowse link
4-methylumbelliferone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD44 CD44 molecule decreases expression EXP Hymecromone results in decreased expression of CD44 mRNA CTD PMID:23139787 NCBI chr 2:25,788,699...25,884,209
Ensembl chr 2:25,788,703...25,884,153 		JBrowse link
G FBN1 fibrillin 1 decreases expression EXP Hymecromone results in decreased expression of FBN1 mRNA CTD PMID:23139787 NCBI chr 1:123,102,011...123,359,649
Ensembl chr 1:123,102,009...123,359,649 		JBrowse link
G FN1 fibronectin 1 decreases expression EXP Hymecromone results in decreased expression of FN1 mRNA; Hymecromone results in decreased expression of FN1 protein CTD PMID:23139787 NCBI chr15:117,658,158...117,737,145
Ensembl chr15:117,658,099...117,731,014 		JBrowse link
G TNC tenascin C decreases expression EXP Hymecromone results in decreased expression of TNC mRNA CTD PMID:23139787 NCBI chr 1:255,533,235...255,630,381
Ensembl chr 1:255,533,238...255,630,376 		JBrowse link
G VCAN versican decreases expression EXP Hymecromone results in decreased expression of VCAN mRNA; Hymecromone results in decreased expression of VCAN protein CTD PMID:23139787 NCBI chr 2:91,682,177...91,811,674
Ensembl chr 2:91,384,391...91,811,208 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5052
    role 5044
      application 863
        probe 12
          fluorescent probe 7
            umbelliferone 6
              3-acetyl-7-beta-D-glucopyranosyloxycoumarin 0
              4-methylumbelliferone + 5
              4-methylumbelliferyl acetate 0
              7-ethoxycoumarin 0
              7-hydroxycoumarin O(7)-glucosiduronic acid 0
              8-geranylumbelliferone 0
              auraptene 0
              osthenol 0
              scopoletin + 0
              umbelliferone sulfate + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 5052
    subatomic particle 5043
      composite particle 5043
        hadron 5071
          baryon 5043
            nucleon 5043
              atomic nucleus 5043
                atom 5043
                  main group element atom 5013
                    p-block element atom 5010
                      carbon group element atom 4927
                        carbon atom 4954
                          organic molecular entity 4926
                            organic molecule 4874
                              organic cyclic compound 4812
                                organic heterocyclic compound 4626
                                  oxacycle 4522
                                    benzopyran 139
                                      1-benzopyran 78
                                        chromenes 25
                                          chromenone 25
                                            coumarins 16
                                              hydroxycoumarin 16
                                                umbelliferone 6
                                                  3-acetyl-7-beta-D-glucopyranosyloxycoumarin 0
                                                  4-methylumbelliferone + 5
                                                  4-methylumbelliferyl acetate 0
                                                  7-ethoxycoumarin 0
                                                  7-hydroxycoumarin O(7)-glucosiduronic acid 0
                                                  8-geranylumbelliferone 0
                                                  auraptene 0
                                                  osthenol 0
                                                  scopoletin + 0
                                                  umbelliferone sulfate + 0
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