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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:simazine
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Accession:CHEBI:27496 term browser browse the term
Definition:A diamino-1,3,5-triazine that is N,N'-diethyl-1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6.
Synonyms:exact_synonym: 6-chloro-N,N'-diethyl-1,3,5-triazine-2,4-diamine
 related_synonym: 2-chloro-4,6-bis(ethylamino)-1,3,5-triazine;   2-chloro-4,6-bis(ethylamino)-s-triazine;   6-chloro-N(2),N(4)-diethyl-1,3,5-triazine-2,4-diamine;   6-chloro-N,N'-diethyl-[1,3,5]triazin-2,4-diamine;   Formula=C7H12ClN5;   Gesatop;   InChI=1S/C7H12ClN5/c1-3-9-6-11-5(8)12-7(13-6)10-4-2/h3-4H2,1-2H3,(H2,9,10,11,12,13);   InChIKey=ODCWYMIRDDJXKW-UHFFFAOYSA-N;   Princep;   SMILES=CCNc1nc(Cl)nc(NCC)n1;   Simanex
 alt_id: CHEBI:26679;   CHEBI:9146
 xref: Beilstein:10895;   CAS:122-34-9;   KEGG:C11172;   LINCS:LSM-19997
 xref_mesh: MESH:D012839
 xref: MetaCyc:CPD-9355;   PMID:12791541;   PMID:14640584;   PMID:15149137;   PMID:19101008;   PPDB:592;   Pesticides:simazine;   Reaxys:10895;   UM-BBD_compID:c0254;   Wikipedia:Simazine



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simazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; Simazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein; U 0126 inhibits the reaction [Simazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein] CTD PMID:27431321 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Simazine results in decreased expression of BCL2 mRNA CTD PMID:25461544 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression ISO Simazine results in decreased expression of BCL2A1 mRNA CTD PMID:25461544 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO Simazine results in decreased expression of BCL2L1 mRNA CTD PMID:25461544 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bcl2l2 Bcl2-like 2 decreases expression ISO Simazine results in decreased expression of BCL2L2 mRNA CTD PMID:25461544 NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Simazine results in decreased expression of CCNB1 mRNA CTD PMID:25461544 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO Simazine results in decreased expression of CCND2 mRNA CTD PMID:25461544 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
JBrowse link
G Comt catechol-O-methyltransferase increases expression
decreases expression
EXP
ISO
Simazine results in increased expression of COMT mRNA
Simazine results in decreased expression of COMT mRNA; Simazine results in decreased expression of COMT protein
CTD PMID:29115391 PMID:29137186 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Creb5 cAMP responsive element binding protein 5 decreases expression ISO Simazine results in decreased expression of CREB5 mRNA CTD PMID:22984576 NCBI chr 4:82,393,091...82,794,320
Ensembl chr 4:82,393,730...82,790,325
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
increases expression
increases activity
ISO formestane inhibits the reaction [Simazine results in increased activity of CYP19A1 protein]
Simazine results in increased expression of CYP19A1 mRNA
CTD PMID:10746939 PMID:11675267 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing ISO CYP1A1 protein results in increased metabolism of Simazine CTD PMID:16248553 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
increases expression
decreases response to substance
EXP
ISO
Simazine results in increased activity of CYP1A2 protein
Simazine results in increased expression of CYP1A2 protein
CYP1A2 protein results in decreased susceptibility to Simazine
CTD PMID:9711812 PMID:26771455 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity EXP Simazine results in decreased activity of CYP2C11 protein CTD PMID:9711812 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression
increases activity
EXP Simazine results in increased expression of CYP4A11 protein; Simazine results in increased expression of CYP4A22 protein
Simazine results in increased activity of CYP4A22 protein
CTD PMID:9711812 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
JBrowse link
G Dbh dopamine beta-hydroxylase multiple interactions
decreases expression
EXP Colforsin inhibits the reaction [Simazine results in decreased expression of DBH protein]; Dexamethasone inhibits the reaction [Simazine results in decreased expression of DBH protein] CTD PMID:14550852 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
JBrowse link
G Ddc dopa decarboxylase decreases expression
affects expression
EXP
ISO
Simazine results in decreased expression of DDC mRNA; Simazine results in decreased expression of DDC protein
Simazine affects the expression of DDC mRNA; Simazine affects the expression of DDC protein
CTD PMID:29115391 PMID:29137186 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
JBrowse link
G Dtwd2 DTW domain containing 2 increases expression ISO Simazine results in increased expression of DTWD2 mRNA CTD PMID:22984576 NCBI chr18:42,811,783...42,902,040
Ensembl chr18:42,816,681...42,901,832
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
affects binding
ISO Simazine inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]
Simazine binds to ESR1 protein
CTD PMID:8858116 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 affects expression ISO Simazine affects the expression of GPER1 mRNA CTD PMID:26955487 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO Simazine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA] CTD PMID:18177342 NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Ifng interferon gamma decreases expression ISO Simazine results in decreased expression of IFNG protein CTD PMID:10883730 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression ISO Simazine results in decreased expression of KIT mRNA CTD PMID:25461544 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
JBrowse link
G Lmx1a LIM homeobox transcription factor 1 alpha increases expression
multiple interactions
decreases expression
ISO Simazine results in increased expression of LMX1A mRNA; Simazine results in increased expression of LMX1A protein
LMX1A protein promotes the reaction [Simazine results in increased expression of NR4A2 mRNA]; LMX1A protein promotes the reaction [Simazine results in increased expression of NR4A2 protein]; LMX1A protein promotes the reaction [Simazine results in increased expression of PITX3 mRNA]; LMX1A protein promotes the reaction [Simazine results in increased expression of PITX3 protein]; LMX1A protein promotes the reaction [Simazine results in increased expression of TH protein]; LMX1A protein promotes the reaction [Simazine results in increased expression of WNT1 mRNA]; LMX1A protein promotes the reaction [Simazine results in increased expression of WNT1 protein]
Simazine results in decreased expression of LMX1A mRNA; Simazine results in decreased expression of LMX1A protein
CTD PMID:32822773 PMID:34936186 NCBI chr13:79,834,614...79,978,253
Ensembl chr13:79,835,019...79,978,253
JBrowse link
G Lmx1b LIM homeobox transcription factor 1 beta increases expression ISO Simazine results in increased expression of LMX1B mRNA; Simazine results in increased expression of LMX1B protein CTD PMID:27513680 PMID:32822773 NCBI chr 3:16,862,195...16,940,899
Ensembl chr 3:16,862,195...16,940,899
JBrowse link
G Maoa monoamine oxidase A decreases expression
affects expression
ISO
EXP
Simazine results in decreased expression of MAOA mRNA
Simazine affects the expression of MAOA mRNA
CTD PMID:29115391 PMID:29137186 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593
JBrowse link
G Maob monoamine oxidase B decreases expression ISO Simazine results in decreased expression of MAOB protein CTD PMID:29137186 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Simazine results in decreased expression of and results in decreased phosphorylation of MAPK1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simazine results in decreased expression of and results in decreased phosphorylation of MAPK1 protein]; Simazine results in decreased expression of and results in decreased phosphorylation of MAPK1 protein; U 0126 inhibits the reaction [Simazine results in decreased expression of and results in decreased phosphorylation of MAPK1 protein]
CTD PMID:27431321 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Simazine results in decreased expression of and results in decreased phosphorylation of MAPK3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simazine results in decreased expression of and results in decreased phosphorylation of MAPK3 protein]; Simazine results in decreased expression of and results in decreased phosphorylation of MAPK3 protein; U 0126 inhibits the reaction [Simazine results in decreased expression of and results in decreased phosphorylation of MAPK3 protein]
CTD PMID:27431321 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mcm7 minichromosome maintenance complex component 7 decreases expression ISO Simazine results in decreased expression of MCM7 mRNA CTD PMID:25461544 NCBI chr12:17,042,207...17,049,470
Ensembl chr12:17,042,212...17,050,063
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO Simazine results in decreased expression of MMP9 mRNA CTD PMID:22984576 PMID:27431321 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mos MOS proto-oncogene, serine/threonine kinase increases expression ISO Simazine results in increased expression of MOS mRNA CTD PMID:22984576 NCBI chr 5:16,859,957...16,861,264
Ensembl chr 5:16,859,957...16,861,264
JBrowse link
G Neurog2 neurogenin 2 increases expression ISO Simazine results in increased expression of NEUROG2 mRNA CTD PMID:27513680 NCBI chr 2:216,092,709...216,095,276
Ensembl chr 2:216,093,363...216,094,154
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Simazine inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein] CTD PMID:17015962 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
ISO Simazine results in decreased expression of NOS2 mRNA; Simazine results in decreased expression of NOS2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simazine results in decreased expression of NOS2 protein]; U 0126 inhibits the reaction [Simazine results in decreased expression of NOS2 protein]
CTD PMID:22984576 PMID:27431321 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression
multiple interactions
ISO Simazine results in decreased expression of NOS3 mRNA; Simazine results in decreased expression of NOS3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simazine results in decreased expression of NOS3 protein]; U 0126 inhibits the reaction [Simazine results in decreased expression of NOS3 protein]
CTD PMID:22984576 PMID:27431321 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 affects expression
decreases expression
increases expression
multiple interactions
ISO
EXP
Simazine affects the expression of NR4A2 mRNA
Simazine results in decreased expression of NR4A2 mRNA; Simazine results in decreased expression of NR4A2 protein
Simazine results in increased expression of NR4A2 mRNA; Simazine results in increased expression of NR4A2 protein
LMX1A protein promotes the reaction [Simazine results in increased expression of NR4A2 mRNA]; LMX1A protein promotes the reaction [Simazine results in increased expression of NR4A2 protein]
CTD PMID:27513680 PMID:29115391 PMID:32822773 PMID:34936186 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 increases expression ISO Simazine results in increased expression of NR5A1 mRNA CTD PMID:17520059 NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328
JBrowse link
G Odc1 ornithine decarboxylase 1 decreases expression EXP Simazine results in decreased expression of ODC1 mRNA CTD PMID:15519604 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Pde4a phosphodiesterase 4A decreases activity ISO Simazine results in decreased activity of PDE4A protein CTD PMID:21251949 NCBI chr 8:19,690,816...19,753,538
Ensembl chr 8:19,703,290...19,751,961
JBrowse link
G Pde5a phosphodiesterase 5A affects activity ISO Simazine affects the activity of PDE5 protein CTD PMID:21251949 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
JBrowse link
G Pgr progesterone receptor multiple interactions EXP Simazine inhibits the reaction [Progesterone binds to PGR protein] CTD PMID:8812239 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Pitx3 paired-like homeodomain 3 increases expression
multiple interactions
decreases expression
ISO Simazine results in increased expression of PITX3 mRNA; Simazine results in increased expression of PITX3 protein
LMX1A protein promotes the reaction [Simazine results in increased expression of PITX3 mRNA]; LMX1A protein promotes the reaction [Simazine results in increased expression of PITX3 protein]
Simazine results in decreased expression of PITX3 mRNA; Simazine results in decreased expression of PITX3 protein
CTD PMID:32822773 PMID:34936186 NCBI chr 1:245,001,106...245,013,881
Ensembl chr 1:245,001,164...245,013,892
JBrowse link
G Plcz1 phospholipase C, zeta 1 increases expression ISO Simazine results in increased expression of PLCZ1 mRNA CTD PMID:22984576 NCBI chr 4:172,873,110...172,929,191
Ensembl chr 4:172,873,112...172,928,358
JBrowse link
G Pomc proopiomelanocortin increases secretion EXP Simazine results in increased secretion of POMC protein modified form CTD PMID:19690231 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Prl prolactin increases expression EXP Simazine results in increased expression of PRL protein CTD PMID:11071396 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Rasal2 RAS protein activator like 2 increases expression ISO Simazine results in increased expression of RASAL2 mRNA CTD PMID:22984576 NCBI chr13:69,279,882...69,569,161
Ensembl chr13:69,258,622...69,569,940
JBrowse link
G Rln1 relaxin 1 multiple interactions ISO Simazine inhibits the reaction [RLN1 protein binds to RXFP1 protein] CTD PMID:27431321 NCBI chr 1:227,079,960...227,082,960
Ensembl chr 1:227,079,966...227,082,882
JBrowse link
G Rxfp1 relaxin family peptide receptor 1 decreases expression
multiple interactions
ISO Simazine results in decreased expression of RXFP1 mRNA; Simazine results in decreased expression of RXFP1 protein
Simazine inhibits the reaction [RLN1 protein binds to RXFP1 protein]
CTD PMID:22984576 PMID:27431321 NCBI chr 2:164,772,270...164,893,484
Ensembl chr 2:164,774,799...164,893,412
JBrowse link
G Scgb2a1 secretoglobin, family 2A, member 1 decreases expression EXP Simazine results in decreased expression of SCGB2A2 mRNA CTD PMID:15519604 NCBI chr 1:206,497,848...206,501,211
Ensembl chr 1:206,497,849...206,501,211
Ensembl chr 1:206,497,849...206,501,211
JBrowse link
G Slc18a2 solute carrier family 18 member A2 decreases expression
affects expression
EXP
ISO
Simazine results in decreased expression of SLC18A2 mRNA; Simazine results in decreased expression of SLC18A2 protein
Simazine affects the expression of SLC18A2 mRNA; Simazine affects the expression of SLC18A2 protein
CTD PMID:29115391 PMID:29137186 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325
JBrowse link
G Slc6a3 solute carrier family 6 member 3 decreases expression
affects expression
EXP
ISO
Simazine results in decreased expression of SLC6A3 mRNA; Simazine results in decreased expression of SLC6A3 protein
Simazine affects the expression of SLC6A3 mRNA; Simazine affects the expression of SLC6A3 protein
CTD PMID:29115391 PMID:29137186 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Spag6 sperm associated antigen 6 decreases expression ISO Simazine results in decreased expression of SPAG6 mRNA CTD PMID:22984576 NCBI chr17:81,352,372...81,401,504
Ensembl chr17:81,349,084...81,401,501
JBrowse link
G Th tyrosine hydroxylase decreases expression
increases expression
affects expression
multiple interactions
EXP
ISO
Simazine results in decreased expression of TH protein
Simazine results in increased expression of TH mRNA; Simazine results in increased expression of TH protein
Simazine affects the expression of TH mRNA; Simazine affects the expression of TH protein
LMX1A protein promotes the reaction [Simazine results in increased expression of TH protein]
Simazine results in decreased expression of TH mRNA; Simazine results in decreased expression of TH protein
CTD PMID:14550852 PMID:27513680 PMID:29137186 PMID:32822773 PMID:34936186 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
ISO Simazine results in decreased expression of TNF protein
Simazine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD PMID:10883730 PMID:15256756 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tssk1b testis-specific serine kinase 1B decreases expression ISO Simazine results in decreased expression of TSSK1 mRNA CTD PMID:22984576 NCBI chr11:83,090,930...83,092,353
Ensembl chr11:83,086,578...83,093,011
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Simazine results in decreased expression of VEGFA mRNA CTD PMID:22984576 PMID:27431321 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Wnt1 Wnt family member 1 increases expression
multiple interactions
decreases expression
ISO Simazine results in increased expression of WNT1 mRNA; Simazine results in increased expression of WNT1 protein
LMX1A protein promotes the reaction [Simazine results in increased expression of WNT1 mRNA]; LMX1A protein promotes the reaction [Simazine results in increased expression of WNT1 protein]
Simazine results in decreased expression of WNT1 mRNA; Simazine results in decreased expression of WNT1 protein
CTD PMID:27513680 PMID:32822773 PMID:34936186 NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      biological role 19892
        xenobiotic 18778
          simazine 57
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    main group molecular entity 19866
                      s-block molecular entity 19698
                        hydrogen molecular entity 19684
                          hydrides 19159
                            inorganic hydride 18151
                              pnictogen hydride 18140
                                nitrogen hydride 18046
                                  azane 17849
                                    ammonia 17848
                                      organic amino compound 17848
                                        polyamine 9031
                                          diamine 8966
                                            diamino-1,3,5-triazine 5109
                                              simazine 57
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