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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methyltestosterone
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Accession:CHEBI:27436 term browser browse the term
Definition:A 17beta-hydroxy steroid that is testosterone bearing a methyl group at the 17alpha position.
Synonyms:exact_synonym: (17beta)-17-hydroxy-17-methylandrost-4-en-3-one
 related_synonym: 17(alpha)-methyl-Delta(4)-androsten-17(beta)-ol-3-one;   17-beta-hydroxy-17-methylandrost-4-en-3-one;   17-methyltestosterone;   17alpha-methyl-3-oxo-4-androsten-17beta-ol;   17alpha-methyl-Delta(4)-androsten-17beta-ol-3-one;   17alpha-methyltestosterone;   17beta-hydroxy-17-methylandrost-4-en-3-one;   4-androstene-17alpha-methyl-17beta-ol-3-one;   Android;   Formula=C20H30O2;   InChI=1S/C20H30O2/c1-18-9-6-14(21)12-13(18)4-5-15-16(18)7-10-19(2)17(15)8-11-20(19,3)22/h12,15-17,22H,4-11H2,1-3H3/t15-,16+,17+,18+,19+,20+/m1/s1;   InChIKey=GCKMFJBGXUYNAG-HLXURNFRSA-N;   NSC-9701;   SMILES=[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@@]1(C)[C@@]2([H])CC[C@]1(C)O;   Testred;   Virilon;   methyltestosteronum;   metiltestosterona
 alt_id: CHEBI:25344;   CHEBI:6892
 xref: CAS:58-18-4;   DrugBank:DB06710;   Drug_Central:3356;   KEGG:C07198;   KEGG:D00408
 xref_mesh: MESH:D008777
 xref: PMID:19199316;   Patent:US2374369;   Patent:US2374370;   Patent:US2384355;   Patent:US2386331;   Patent:US2435013;   Reaxys:2057425


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methyltestosterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of ABCB11 mRNA CTD PMID:27344345 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of ABCB4 mRNA CTD PMID:27344345 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of ABCC3 mRNA CTD PMID:27344345 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of ABCG5 mRNA CTD PMID:27344345 NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of ALAS1 mRNA CTD PMID:27344345 NCBI chr 8:114,927,704...114,941,038
Ensembl chr 8:114,927,722...114,940,177
JBrowse link
G Ar androgen receptor multiple interactions
increases activity
affects binding
ISO
EXP
Methyltestosterone binds to and results in increased activity of AR protein
Methyltestosterone results in increased activity of AR protein
Methyltestosterone binds to AR protein
CTD PMID:12730620, PMID:14565775, PMID:19833195, PMID:20371976, PMID:20438827, PMID:26867867 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP [Gossypol co-treated with Methyltestosterone co-treated with Ethinyl Estradiol] results in increased expression of BAX mRNA CTD PMID:15451339 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G C3 complement C3 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of C3 mRNA CTD PMID:27344345 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G Casp3 caspase 3 multiple interactions EXP [Gossypol co-treated with Methyltestosterone co-treated with Ethinyl Estradiol] results in increased expression of CASP3 mRNA CTD PMID:15451339 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions EXP [Gossypol co-treated with Methyltestosterone co-treated with Ethinyl Estradiol] results in increased expression of CASP9 mRNA CTD PMID:15451339 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of COL3A1 mRNA CTD PMID:27344345 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions ISO Methyltestosterone inhibits the reaction [CYP19A1 protein affects the metabolism of Androstenedione] CTD PMID:12628686 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP
ISO
Methyltestosterone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:18493746 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of CYP27A1 mRNA CTD PMID:27344345 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of CYP2C8 mRNA CTD PMID:27344345 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of CYP2E1 mRNA CTD PMID:27344345 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of DDIT3 mRNA CTD PMID:27344345 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of ERN1 mRNA CTD PMID:27344345 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Esr1 estrogen receptor 1 increases activity
multiple interactions
EXP
ISO
Methyltestosterone results in increased activity of ESR1 protein
Methyltestosterone binds to and results in increased activity of ESR1 protein; Methyltestosterone promotes the reaction [ESR1 protein modified form binds to NCOA1 protein modified form]; Methyltestosterone promotes the reaction [ESR1 protein modified form binds to NRIP1 protein modified form]
CTD PMID:12504345, PMID:23383871, PMID:25012808, PMID:29162470 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G F9 coagulation factor IX multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of F9 mRNA CTD PMID:27344345 NCBI chr  X:143,097,507...143,141,791
Ensembl chr  X:143,097,525...143,141,794
JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP [Gossypol co-treated with Methyltestosterone co-treated with Ethinyl Estradiol] results in increased expression of FAS mRNA CTD PMID:15451339 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fdps farnesyl diphosphate synthase multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of FDPS mRNA CTD PMID:27344345 NCBI chr 2:188,403,595...188,413,219
Ensembl chr 2:188,392,858...188,413,219
JBrowse link
G Fetub fetuin B multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of FETUB mRNA CTD PMID:27344345 NCBI chr11:81,648,890...81,660,472
Ensembl chr11:81,648,885...81,660,395
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of GADD45A mRNA CTD PMID:27344345 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of IL1RL1 mRNA CTD PMID:27344345 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of IL1RN mRNA CTD PMID:27344345 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of JUN mRNA CTD PMID:27344345 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Klf6 Kruppel-like factor 6 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of KLF6 mRNA CTD PMID:27344345 NCBI chr17:67,887,939...67,945,052
Ensembl chr17:67,887,939...67,945,037
JBrowse link
G Kng2 kininogen 2 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of KNG1 mRNA CTD PMID:27344345 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Lrp5 LDL receptor related protein 5 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of LRP5 mRNA CTD PMID:27344345 NCBI chr 1:218,816,833...218,920,147
Ensembl chr 1:218,816,841...218,920,094
JBrowse link
G Lss lanosterol synthase multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of LSS mRNA CTD PMID:27344345 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497
JBrowse link
G Maff MAF bZIP transcription factor F multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of MAFF mRNA CTD PMID:27344345 NCBI chr 7:120,580,743...120,592,095
Ensembl chr 7:120,580,743...120,592,095
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of MET mRNA CTD PMID:27344345 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Methyltestosterone promotes the reaction [ESR1 protein modified form binds to NCOA1 protein modified form] CTD PMID:23383871 NCBI chr 6:28,677,563...28,931,844
Ensembl chr 6:28,677,540...28,931,843
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects binding EXP Methyltestosterone binds to NR3C1 protein CTD PMID:14698206 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nrip1 nuclear receptor interacting protein 1 multiple interactions ISO Methyltestosterone promotes the reaction [ESR1 protein modified form binds to NRIP1 protein modified form] CTD PMID:23383871 NCBI chr11:14,658,225...14,742,478
Ensembl chr11:14,658,225...14,741,563
JBrowse link
G Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of PAPSS2 mRNA CTD PMID:27344345 NCBI chr 1:251,145,264...251,230,716
Ensembl chr 1:251,145,253...251,230,715
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP [Contraceptives, Oral, Combined co-treated with Methyltestosterone] results in decreased expression of PCNA protein CTD PMID:10964026 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pgr progesterone receptor multiple interactions EXP [Contraceptives, Oral, Combined co-treated with Methyltestosterone] results in increased expression of PGR protein CTD PMID:10964026 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of PRKCA mRNA CTD PMID:27344345 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of PTGS2 mRNA CTD PMID:27344345 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of RXRA mRNA CTD PMID:27344345 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of SCARB1 mRNA CTD PMID:27344345 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
JBrowse link
G Sdc1 syndecan 1 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of SDC1 mRNA CTD PMID:27344345 NCBI chr 6:33,885,576...33,908,038
Ensembl chr 6:33,885,495...33,908,016
JBrowse link
G Serpind1 serpin family D member 1 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of SERPIND1 mRNA CTD PMID:27344345 NCBI chr11:87,913,814...87,924,880
Ensembl chr11:87,913,806...87,924,816
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Methyltestosterone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of SLC22A7 mRNA CTD PMID:27344345 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766
JBrowse link
G Slc51b solute carrier family 51 subunit beta multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of SLC51B mRNA CTD PMID:27344345 NCBI chr 8:70,930,196...70,938,559
Ensembl chr 8:70,930,347...70,932,986
JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 decreases activity ISO Methyltestosterone results in decreased activity of SRD5A2 protein CTD PMID:17218080 NCBI chr 6:25,279,635...25,315,501
Ensembl chr 6:25,279,626...25,315,511
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of TNFSF10 mRNA CTD PMID:27344345 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of VCAM1 mRNA CTD PMID:27344345 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link

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  CHEBI ontology 19785
    role 19732
      application 19391
        pharmaceutical 19272
          drug 19272
            antineoplastic agent 16982
              methyltestosterone 51
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      ketone 16140
                                        oxo steroid 9275
                                          3-oxo steroid 8805
                                            3-oxo-Delta(4) steroid 7934
                                              testosterone 2845
                                                methyltestosterone 51
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