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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methyltestosterone
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Accession:CHEBI:27436 term browser browse the term
Definition:A 17beta-hydroxy steroid that is testosterone bearing a methyl group at the 17alpha position.
Synonyms:exact_synonym: (17beta)-17-hydroxy-17-methylandrost-4-en-3-one
 related_synonym: 17(alpha)-methyl-Delta(4)-androsten-17(beta)-ol-3-one;   17-beta-hydroxy-17-methylandrost-4-en-3-one;   17-methyltestosterone;   17alpha-methyl-3-oxo-4-androsten-17beta-ol;   17alpha-methyl-Delta(4)-androsten-17beta-ol-3-one;   17alpha-methyltestosterone;   17beta-hydroxy-17-methylandrost-4-en-3-one;   4-androstene-17alpha-methyl-17beta-ol-3-one;   Android;   Formula=C20H30O2;   InChI=1S/C20H30O2/c1-18-9-6-14(21)12-13(18)4-5-15-16(18)7-10-19(2)17(15)8-11-20(19,3)22/h12,15-17,22H,4-11H2,1-3H3/t15-,16+,17+,18+,19+,20+/m1/s1;   InChIKey=GCKMFJBGXUYNAG-HLXURNFRSA-N;   NSC-9701;   SMILES=[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@@]1(C)[C@@]2([H])CC[C@]1(C)O;   Testred;   Virilon;   methyltestosteronum;   metiltestosterona
 alt_id: CHEBI:25344;   CHEBI:6892
 xref: CAS:58-18-4;   DrugBank:DB06710;   Drug_Central:3356;   KEGG:C07198;   KEGG:D00408
 xref_mesh: MESH:D008777
 xref: PMID:19199316;   Patent:US2374369;   Patent:US2374370;   Patent:US2384355;   Patent:US2386331;   Patent:US2435013;   Reaxys:2057425


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methyltestosterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of ABCB11 mRNA CTD PMID:27344345 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of ABCB4 mRNA CTD PMID:27344345 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of ABCC3 mRNA CTD PMID:27344345 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of ABCG5 mRNA CTD PMID:27344345 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of ALAS1 mRNA CTD PMID:27344345 NCBI chr 8:106,876,514...106,889,852
Ensembl chr 8:106,876,514...106,889,917
JBrowse link
G Ar androgen receptor multiple interactions
increases activity
affects binding
ISO
EXP
Methyltestosterone binds to and results in increased activity of AR protein
Methyltestosterone results in increased activity of AR protein
Methyltestosterone binds to AR protein
CTD PMID:12730620 PMID:14565775 PMID:19833195 PMID:20371976 PMID:20438827 More... NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP [Gossypol co-treated with Methyltestosterone co-treated with Ethinyl Estradiol] results in increased expression of BAX mRNA CTD PMID:15451339 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G C3 complement C3 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of C3 mRNA CTD PMID:27344345 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G Casp3 caspase 3 multiple interactions EXP [Gossypol co-treated with Methyltestosterone co-treated with Ethinyl Estradiol] results in increased expression of CASP3 mRNA CTD PMID:15451339 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions EXP [Gossypol co-treated with Methyltestosterone co-treated with Ethinyl Estradiol] results in increased expression of CASP9 mRNA CTD PMID:15451339 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of COL3A1 mRNA CTD PMID:27344345 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions ISO Methyltestosterone inhibits the reaction [CYP19A1 protein affects the metabolism of Androstenedione] CTD PMID:12628686 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP
ISO
Methyltestosterone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:18493746 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of CYP27A1 mRNA CTD PMID:27344345 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of CYP2C8 mRNA CTD PMID:27344345
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of CYP2E1 mRNA CTD PMID:27344345 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of DDIT3 mRNA CTD PMID:27344345 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of ERN1 mRNA CTD PMID:27344345 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Esr1 estrogen receptor 1 increases activity
multiple interactions
EXP
ISO
Methyltestosterone results in increased activity of ESR1 protein
Methyltestosterone binds to and results in increased activity of ESR1 protein; Methyltestosterone promotes the reaction [ESR1 protein modified form binds to NCOA1 protein modified form]; Methyltestosterone promotes the reaction [ESR1 protein modified form binds to NRIP1 protein modified form]
CTD PMID:12504345 PMID:23383871 PMID:25012808 PMID:29162470 PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Methyltestosterone binds to and results in increased activity of ESR2 protein CTD PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G F9 coagulation factor IX multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of F9 mRNA CTD PMID:27344345 NCBI chr  X:138,352,334...138,396,835
Ensembl chr  X:138,352,298...138,396,835
JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP [Gossypol co-treated with Methyltestosterone co-treated with Ethinyl Estradiol] results in increased expression of FAS mRNA CTD PMID:15451339 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fdps farnesyl diphosphate synthase multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of FDPS mRNA CTD PMID:27344345 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
JBrowse link
G Fetub fetuin B multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of FETUB mRNA CTD PMID:27344345 NCBI chr11:78,082,158...78,093,022
Ensembl chr11:78,082,156...78,095,135
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of GADD45A mRNA CTD PMID:27344345 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of IL1RL1 mRNA CTD PMID:27344345 NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of IL1RN mRNA CTD PMID:27344345 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of JUN mRNA CTD PMID:27344345 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Klf6 Kruppel-like factor 6 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of KLF6 mRNA CTD PMID:27344345 NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570
JBrowse link
G Kng2 kininogen 2 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of KNG1 mRNA CTD PMID:27344345 NCBI chr11:77,913,876...77,936,247 JBrowse link
G Lrp5 LDL receptor related protein 5 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of LRP5 mRNA CTD PMID:27344345 NCBI chr 1:200,814,247...200,917,581
Ensembl chr 1:200,814,250...200,917,581
JBrowse link
G Lss lanosterol synthase multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of LSS mRNA CTD PMID:27344345 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
JBrowse link
G Maff MAF bZIP transcription factor F multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of MAFF mRNA CTD PMID:27344345 NCBI chr 7:110,912,499...110,923,851
Ensembl chr 7:110,912,499...110,923,851
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of MET mRNA CTD PMID:27344345 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Methyltestosterone promotes the reaction [ESR1 protein modified form binds to NCOA1 protein modified form] CTD PMID:23383871 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Methyltestosterone binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects binding EXP Methyltestosterone binds to NR3C1 protein CTD PMID:14698206 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nrip1 nuclear receptor interacting protein 1 multiple interactions ISO Methyltestosterone promotes the reaction [ESR1 protein modified form binds to NRIP1 protein modified form] CTD PMID:23383871 NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761
JBrowse link
G Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of PAPSS2 mRNA CTD PMID:27344345 NCBI chr 1:230,454,314...230,539,332
Ensembl chr 1:230,454,426...230,539,331
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP [Contraceptives, Oral, Combined co-treated with Methyltestosterone] results in decreased expression of PCNA protein CTD PMID:10964026 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pgr progesterone receptor multiple interactions EXP [Contraceptives, Oral, Combined co-treated with Methyltestosterone] results in increased expression of PGR protein CTD PMID:10964026 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of PRKCA mRNA CTD PMID:27344345 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of PTGS2 mRNA CTD PMID:27344345 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of RXRA mRNA CTD PMID:27344345 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of SCARB1 mRNA CTD PMID:27344345 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
JBrowse link
G Sdc1 syndecan 1 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of SDC1 mRNA CTD PMID:27344345 NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264
JBrowse link
G Serpind1 serpin family D member 1 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of SERPIND1 mRNA CTD PMID:27344345 NCBI chr11:83,664,517...83,675,593
Ensembl chr11:83,664,518...83,675,519
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Methyltestosterone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of SLC22A7 mRNA CTD PMID:27344345 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
JBrowse link
G Slc51b solute carrier family 51 subunit beta multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of SLC51B mRNA CTD PMID:27344345 NCBI chr 8:65,931,891...65,934,893
Ensembl chr 8:65,931,890...65,940,145
JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 decreases activity ISO Methyltestosterone results in decreased activity of SRD5A2 protein CTD PMID:17218080 NCBI chr 6:21,426,225...21,465,727
Ensembl chr 6:21,426,215...21,462,112
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of TNFSF10 mRNA CTD PMID:27344345 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO [Methyltestosterone co-treated with Cholic Acids] affects the expression of VCAM1 mRNA CTD PMID:27344345 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link

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  CHEBI ontology 19821
    role 19769
      application 19481
        pharmaceutical 19329
          drug 19329
            antineoplastic agent 17317
              methyltestosterone 53
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  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      ketone 16923
                                        oxo steroid 9720
                                          3-oxo steroid 9279
                                            3-oxo-Delta(4) steroid 8420
                                              testosterone 3620
                                                methyltestosterone 53
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