CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: methyltestosterone
Accession: CHEBI:27436
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Definition: A 17beta-hydroxy steroid that is testosterone bearing a methyl group at the 17alpha position.
Synonyms: exact_synonym: (17beta)-17-hydroxy-17-methylandrost-4-en-3-one
related_synonym: 17(alpha)-methyl-Delta(4)-androsten-17(beta)-ol-3-one; 17-beta-hydroxy-17-methylandrost-4-en-3-one; 17-methyltestosterone; 17alpha-methyl-3-oxo-4-androsten-17beta-ol; 17alpha-methyl-Delta(4)-androsten-17beta-ol-3-one; 17alpha-methyltestosterone; 17beta-hydroxy-17-methylandrost-4-en-3-one; 4-androstene-17alpha-methyl-17beta-ol-3-one; Android; Formula=C20H30O2; InChI=1S/C20H30O2/c1-18-9-6-14(21)12-13(18)4-5-15-16(18)7-10-19(2)17(15)8-11-20(19,3)22/h12,15-17,22H,4-11H2,1-3H3/t15-,16+,17+,18+,19+,20+/m1/s1; InChIKey=GCKMFJBGXUYNAG-HLXURNFRSA-N; NSC-9701; SMILES=[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@@]1(C)[C@@]2([H])CC[C@]1(C)O; Testred; Virilon; methyltestosteronum; metiltestosterona
alt_id: CHEBI:25344; CHEBI:6892
xref: CAS:58-18-4; DrugBank:DB06710; Drug_Central:3356; KEGG:C07198; KEGG:D00408
xref_mesh: MESH:D008777
xref: PMID:19199316; Patent:US2374369; Patent:US2374370; Patent:US2384355; Patent:US2386331; Patent:US2435013; Reaxys:2057425
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Abcb11
ATP binding cassette subfamily B member 11
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of ABCB11 mRNA
CTD
PMID:27344345
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Abcb4
ATP binding cassette subfamily B member 4
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of ABCB4 mRNA
CTD
PMID:27344345
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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Abcc3
ATP binding cassette subfamily C member 3
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of ABCC3 mRNA
CTD
PMID:27344345
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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Abcg5
ATP binding cassette subfamily G member 5
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of ABCG5 mRNA
CTD
PMID:27344345
NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
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Alas1
5'-aminolevulinate synthase 1
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of ALAS1 mRNA
CTD
PMID:27344345
NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917
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Ar
androgen receptor
multiple interactions affects binding increases activity
ISO EXP
Methyltestosterone binds to and results in increased activity of AR protein Methyltestosterone binds to AR protein Methyltestosterone results in increased activity of AR protein
CTD
PMID:12730620 PMID:14565775 PMID:19833195 PMID:20371976 PMID:20438827 PMID:26867867 PMID:33049310 More...
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
EXP
[Gossypol co-treated with Methyltestosterone co-treated with Ethinyl Estradiol] results in increased expression of BAX mRNA
CTD
PMID:15451339
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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C3
complement C3
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of C3 mRNA
CTD
PMID:27344345
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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Casp3
caspase 3
multiple interactions
EXP
[Gossypol co-treated with Methyltestosterone co-treated with Ethinyl Estradiol] results in increased expression of CASP3 mRNA
CTD
PMID:15451339
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9
caspase 9
multiple interactions
EXP
[Gossypol co-treated with Methyltestosterone co-treated with Ethinyl Estradiol] results in increased expression of CASP9 mRNA
CTD
PMID:15451339
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Col3a1
collagen type III alpha 1 chain
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of COL3A1 mRNA
CTD
PMID:27344345
NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
multiple interactions
ISO
Methyltestosterone inhibits the reaction [CYP19A1 protein affects the metabolism of Androstenedione]
CTD
PMID:12628686
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions
EXP ISO
Methyltestosterone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
CTD
PMID:18493746
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of CYP27A1 mRNA
CTD
PMID:27344345
NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
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Cyp2c79
cytochrome P450, family 2, subfamily c, polypeptide 79
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of CYP2C8 mRNA
CTD
PMID:27344345
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of CYP2E1 mRNA
CTD
PMID:27344345
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Ddit3
DNA-damage inducible transcript 3
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of DDIT3 mRNA
CTD
PMID:27344345
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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Ern1
endoplasmic reticulum to nucleus signaling 1
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of ERN1 mRNA
CTD
PMID:27344345
NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
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Esr1
estrogen receptor 1
increases activity multiple interactions increases expression
EXP ISO
Methyltestosterone results in increased activity of ESR1 protein Methyltestosterone binds to and results in increased activity of ESR1 protein; Methyltestosterone promotes the reaction [ESR1 protein modified form binds to NCOA1 protein modified form]; Methyltestosterone promotes the reaction [ESR1 protein modified form binds to NRIP1 protein modified form] Methyltestosterone results in increased expression of ESR1 protein
CTD
PMID:12504345 PMID:23383871 PMID:25012808 PMID:29162470 PMID:33049310 PMID:38133387 More...
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Esr2
estrogen receptor 2
multiple interactions
ISO
Methyltestosterone binds to and results in increased activity of ESR2 protein
CTD
PMID:33049310
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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F9
coagulation factor IX
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of F9 mRNA
CTD
PMID:27344345
NCBI chr X:138,352,334...138,396,835
Ensembl chr X:138,352,298...138,396,835
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Fas
Fas cell surface death receptor
multiple interactions
EXP
[Gossypol co-treated with Methyltestosterone co-treated with Ethinyl Estradiol] results in increased expression of FAS mRNA
CTD
PMID:15451339
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Fdps
farnesyl diphosphate synthase
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of FDPS mRNA
CTD
PMID:27344345
NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
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Fetub
fetuin B
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of FETUB mRNA
CTD
PMID:27344345
NCBI chr11:78,082,158...78,093,022
Ensembl chr11:78,082,156...78,095,135
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Gadd45a
growth arrest and DNA-damage-inducible, alpha
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of GADD45A mRNA
CTD
PMID:27344345
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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Greb1
growth regulating estrogen receptor binding 1
increases expression
ISO
Methyltestosterone results in increased expression of GREB1 mRNA
CTD
PMID:35307500
NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633
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Il1rl1
interleukin 1 receptor-like 1
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of IL1RL1 mRNA
CTD
PMID:27344345
NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
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Il1rn
interleukin 1 receptor antagonist
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of IL1RN mRNA
CTD
PMID:27344345
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of JUN mRNA
CTD
PMID:27344345
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Klf6
KLF transcription factor 6
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of KLF6 mRNA
CTD
PMID:27344345
NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570
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Klk1c10
kallikrein 1-related peptidase C10
increases secretion
ISO
Methyltestosterone results in increased secretion of KLK3 protein
CTD
PMID:20363314
NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052
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Kng1
kininogen 1
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of KNG1 mRNA
CTD
PMID:27344345
NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555
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Lrp5
LDL receptor related protein 5
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of LRP5 mRNA
CTD
PMID:27344345
NCBI chr 1:200,814,247...200,917,581
Ensembl chr 1:200,814,250...200,917,581
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Lss
lanosterol synthase
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of LSS mRNA
CTD
PMID:27344345
NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
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Maff
MAF bZIP transcription factor F
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of MAFF mRNA
CTD
PMID:27344345
NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851
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Met
MET proto-oncogene, receptor tyrosine kinase
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of MET mRNA
CTD
PMID:27344345
NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
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Ncoa1
nuclear receptor coactivator 1
multiple interactions
ISO
Methyltestosterone promotes the reaction [ESR1 protein modified form binds to NCOA1 protein modified form]
CTD
PMID:23383871
NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
Methyltestosterone binds to and results in increased activity of NR1I2 protein
CTD
PMID:33049310
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
affects binding
EXP
Methyltestosterone binds to NR3C1 protein
CTD
PMID:14698206
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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Nrip1
nuclear receptor interacting protein 1
multiple interactions
ISO
Methyltestosterone promotes the reaction [ESR1 protein modified form binds to NRIP1 protein modified form]
CTD
PMID:23383871
NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761
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Papss2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of PAPSS2 mRNA
CTD
PMID:27344345
NCBI chr 1:230,454,314...230,539,332
Ensembl chr 1:230,454,426...230,539,331
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Pcna
proliferating cell nuclear antigen
multiple interactions
EXP
[Contraceptives, Oral, Combined co-treated with Methyltestosterone] results in decreased expression of PCNA protein
CTD
PMID:10964026
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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Pgr
progesterone receptor
multiple interactions
EXP
[Contraceptives, Oral, Combined co-treated with Methyltestosterone] results in increased expression of PGR protein
CTD
PMID:10964026
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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Prkca
protein kinase C, alpha
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of PRKCA mRNA
CTD
PMID:27344345
NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of PTGS2 mRNA
CTD
PMID:27344345
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Rxra
retinoid X receptor alpha
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of RXRA mRNA
CTD
PMID:27344345
NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
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Scarb1
scavenger receptor class B, member 1
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of SCARB1 mRNA
CTD
PMID:27344345
NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
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Sdc1
syndecan 1
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of SDC1 mRNA
CTD
PMID:27344345
NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264
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Serpind1
serpin family D member 1
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of SERPIND1 mRNA
CTD
PMID:27344345
NCBI chr11:83,664,517...83,675,593
Ensembl chr11:83,664,518...83,675,519
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Methyltestosterone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Slc22a7
solute carrier family 22 member 7
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of SLC22A7 mRNA
CTD
PMID:27344345
NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
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Slc51b
SLC51 subunit beta
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of SLC51B mRNA
CTD
PMID:27344345
NCBI chr 8:65,931,891...65,939,953
Ensembl chr 8:65,931,890...65,940,145
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Srd5a2
steroid 5 alpha-reductase 2
decreases activity
ISO
Methyltestosterone results in decreased activity of SRD5A2 protein
CTD
PMID:17218080
NCBI chr 6:21,426,225...21,465,727
Ensembl chr 6:21,426,215...21,462,112
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Tff1
trefoil factor 1
increases expression
ISO
Methyltestosterone results in increased expression of TFF1 mRNA
CTD
PMID:35307500
NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
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Tnfsf10
TNF superfamily member 10
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of TNFSF10 mRNA
CTD
PMID:27344345
NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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Vcam1
vascular cell adhesion molecule 1
multiple interactions
ISO
[Methyltestosterone co-treated with Cholic Acids] affects the expression of VCAM1 mRNA
CTD
PMID:27344345
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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