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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alpha-linolenic acid
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Accession:CHEBI:27432 term browser browse the term
Definition:A linolenic acid with cis-double bonds at positions 9, 12 and 15. Shown to have an antithrombotic effect.
Synonyms:exact_synonym: (9Z,12Z,15Z)-octadeca-9,12,15-trienoic acid
 related_synonym: (9,12,15)-linolenic acid;   (9Z,12Z,15Z)-Octadecatrienoic acid;   (Z,Z,Z)-9,12,15-octadecatrienoic acid;   9,12,15-Octadecatrienoic acid;   ALA;   Formula=C18H30O2;   InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-;   InChIKey=DTOSIQBPPRVQHS-PDBXOOCHSA-N;   SMILES=CC\\C=C/C\\C=C/C\\C=C/CCCCCCCC(O)=O;   all-cis-9,12,15-octadecatrienoic acid;   cis,cis,cis-9,12,15-octadecatrienoic acid;   cis-Delta(9,12,15)-octadecatrienoic acid;   linolenic acid
 alt_id: CHEBI:10298;   CHEBI:22462;   CHEBI:43891
 xref: Beilstein:1727693;   CAS:463-40-1;   DrugBank:DB00132;   Drug_Central:4618;   Gmelin:57558;   HMDB:HMDB0001388;   KEGG:C06427;   KNApSAcK:C00007247;   LIPID_MAPS_instance:LMFA01030152
 xref_mesh: MESH:D017962
 xref: MetaCyc:LINOLENIC_ACID;   PDBeChem:LNL;   PMID:10232625;   PMID:11304127;   PMID:19269799;   PMID:24320056;   PMID:24639012;   PMID:24855655;   Reaxys:1727693;   Wikipedia:Alpha-Linolenic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:32387;   is_conjugate_acid_of CHEBI:528881


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alpha-linolenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 multiple interactions EXP alpha-Linolenic Acid promotes the reaction [GW 4064 results in increased expression of ABCB11 mRNA] CTD PMID:15307955 NCBI chr 2:168,915,468...169,031,396
Ensembl chr 2:168,915,498...169,031,324
JBrowse link
G ACACA acetyl-CoA carboxylase alpha decreases expression ISO alpha-Linolenic Acid results in decreased expression of ACACA mRNA CTD PMID:14563831 NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836
JBrowse link
G ACLY ATP citrate lyase decreases expression ISO alpha-Linolenic Acid results in decreased expression of ACLY mRNA CTD PMID:14563831 NCBI chr17:41,866,916...41,930,542
Ensembl chr17:41,866,917...41,930,542
JBrowse link
G BCHE butyrylcholinesterase increases expression
increases secretion
EXP alpha-Linolenic Acid results in increased expression of BCHE mRNA
alpha-Linolenic Acid results in increased secretion of BCHE protein
CTD PMID:27106529 NCBI chr 3:165,772,904...165,837,423
Ensembl chr 3:165,772,904...165,837,462
JBrowse link
G CAT catalase multiple interactions ISO alpha-Linolenic Acid inhibits the reaction [methylmercuric chloride results in decreased activity of CAT protein] CTD PMID:22269903 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions ISO alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 protein]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 protein]] CTD PMID:29423081 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CEBPB CCAAT enhancer binding protein beta decreases expression ISO alpha-Linolenic Acid results in decreased expression of CEBPB mRNA CTD PMID:14563831 NCBI chr20:50,190,583...50,192,690
Ensembl chr20:50,190,830...50,192,668
JBrowse link
G CPT1A carnitine palmitoyltransferase 1A increases expression EXP alpha-Linolenic Acid results in increased expression of CPT1A mRNA CTD PMID:15307955 NCBI chr11:68,754,620...68,844,410
Ensembl chr11:68,754,620...68,844,410
JBrowse link
G CYBB cytochrome b-245 beta chain multiple interactions ISO alpha-Linolenic Acid inhibits the reaction [[Cholesterol co-treated with Particulate Matter] results in increased expression of CYBB protein] CTD PMID:30672636 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,059...37,813,461
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases activity EXP alpha-Linolenic Acid results in decreased activity of CYP1A2 protein CTD PMID:16978661 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP24A1 cytochrome P450 family 24 subfamily A member 1 multiple interactions EXP alpha-Linolenic Acid inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA] CTD PMID:19667161 NCBI chr20:54,145,731...54,174,032
Ensembl chr20:54,153,446...54,173,986
JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 increases expression
multiple interactions
EXP alpha-Linolenic Acid results in increased expression of CYP2A6 mRNA; alpha-Linolenic Acid results in increased expression of CYP2A6 protein
NFE2L2 protein promotes the reaction [alpha-Linolenic Acid results in increased expression of CYP2A6 mRNA]; NFE2L2 protein promotes the reaction [alpha-Linolenic Acid results in increased expression of CYP2A6 protein]
CTD PMID:28555106 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 decreases activity
multiple interactions
EXP alpha-Linolenic Acid results in decreased activity of CYP2C19 protein
CYP2C19 protein results in increased metabolism of [alpha-Linolenic Acid co-treated with NADP]
CTD PMID:16978661 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 decreases activity
multiple interactions
EXP alpha-Linolenic Acid results in decreased activity of CYP2C9 protein
CYP2C9 protein results in increased metabolism of [alpha-Linolenic Acid co-treated with NADP]
CTD PMID:16978661 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases activity EXP alpha-Linolenic Acid results in decreased activity of CYP2E1 protein CTD PMID:16978661 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 decreases activity EXP alpha-Linolenic Acid results in decreased activity of CYP3A4 protein CTD PMID:16978661 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G DIO1 iodothyronine deiodinase 1 decreases activity EXP alpha-Linolenic Acid results in decreased activity of DIO1 protein CTD PMID:30561685 NCBI chr 1:53,894,187...53,911,086
Ensembl chr 1:53,891,239...53,911,086
JBrowse link
G DIO2 iodothyronine deiodinase 2 decreases activity EXP alpha-Linolenic Acid results in decreased activity of DIO2 protein CTD PMID:30561685 NCBI chr14:80,197,526...80,231,057
Ensembl chr14:80,197,527...80,387,757
Ensembl chr14:80,197,527...80,387,757
JBrowse link
G DIO3 iodothyronine deiodinase 3 decreases activity EXP alpha-Linolenic Acid results in decreased activity of DIO3 protein CTD PMID:30561685 NCBI chr14:101,561,351...101,563,452
Ensembl chr14:101,561,351...101,563,452
JBrowse link
G FADS1 fatty acid desaturase 1 multiple interactions EXP [[alpha-Linolenic Acid co-treated with Estradiol] results in increased expression of FADS1 mRNA] which affects the abundance of Fatty Acids, Unsaturated; [[alpha-Linolenic Acid co-treated with Testosterone] results in decreased expression of FADS1 mRNA] which affects the abundance of Fatty Acids, Unsaturated; [alpha-Linolenic Acid co-treated with Estradiol] results in increased expression of FADS1 mRNA; [alpha-Linolenic Acid co-treated with Testosterone] results in decreased expression of FADS1 mRNA; fulvestrant inhibits the reaction [[alpha-Linolenic Acid co-treated with Estradiol] results in increased expression of FADS1 mRNA] CTD PMID:19576517 NCBI chr11:61,799,627...61,817,003
Ensembl chr11:61,799,627...61,829,318
JBrowse link
G FASN fatty acid synthase decreases expression ISO alpha-Linolenic Acid results in decreased expression of FASN mRNA CTD PMID:14563831 NCBI chr17:82,078,338...82,098,303
Ensembl chr17:82,078,338...82,098,294
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases activity
increases expression
EXP alpha-Linolenic Acid results in increased activity of GCLC protein
alpha-Linolenic Acid results in increased expression of GCLC mRNA
CTD PMID:17092368 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO alpha-Linolenic Acid inhibits the reaction [methylmercuric chloride results in increased activity of GPT protein] CTD PMID:22269903 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
JBrowse link
G GSTA1 glutathione S-transferase alpha 1 multiple interactions
increases expression
EXP NFE2L2 protein promotes the reaction [alpha-Linolenic Acid results in increased expression of GSTA1 mRNA] CTD PMID:28555106 NCBI chr 6:52,791,371...52,803,827
Ensembl chr 6:52,791,371...52,803,860
JBrowse link
G HMOX1 heme oxygenase 1 increases expression
multiple interactions
EXP
ISO
alpha-Linolenic Acid results in increased expression of HMOX1 mRNA
alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [Cholesterol results in increased expression of HMOX1 mRNA]]
CTD PMID:17092368 PMID:30672636 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G IFNG interferon gamma multiple interactions ISO alpha-Linolenic Acid inhibits the reaction [[Cholesterol co-treated with Particulate Matter] results in increased expression of IFNG protein]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG protein]] CTD PMID:29423081 PMID:30672636 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP
ISO
[Eicosapentaenoic Acid co-treated with Docosahexaenoic Acids co-treated with alpha-Linolenic Acid] results in increased expression of IL1B protein
alpha-Linolenic Acid inhibits the reaction [[Cholesterol co-treated with Particulate Matter] results in increased expression of IL1B protein]
CTD PMID:16305726 PMID:30672636 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL4 interleukin 4 multiple interactions EXP [Eicosapentaenoic Acid co-treated with Docosahexaenoic Acids co-treated with alpha-Linolenic Acid] results in decreased expression of IL4 protein CTD PMID:16305726 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G IL6 interleukin 6 multiple interactions ISO alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 protein]; alpha-Linolenic Acid inhibits the reaction [Cholesterol promotes the reaction [Particulate Matter results in increased expression of IL6 protein]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 protein]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 mRNA]] CTD PMID:29423081 PMID:30672636 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G KNG1 kininogen 1 multiple interactions EXP alpha-Linolenic Acid inhibits the reaction [GW 4064 results in increased expression of KNG1 mRNA] CTD PMID:15307955 NCBI chr 3:186,717,359...186,744,410
Ensembl chr 3:186,717,348...186,744,410
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions EXP
ISO
NFE2L2 protein promotes the reaction [alpha-Linolenic Acid results in increased expression of CYP2A6 mRNA]; NFE2L2 protein promotes the reaction [alpha-Linolenic Acid results in increased expression of CYP2A6 protein]; NFE2L2 protein promotes the reaction [alpha-Linolenic Acid results in increased expression of GSTA1 mRNA]
alpha-Linolenic Acid inhibits the reaction [Cholesterol promotes the reaction [Particulate Matter results in increased expression of NFE2L2 mRNA]]; alpha-Linolenic Acid inhibits the reaction [Cholesterol results in increased expression of NFE2L2 mRNA]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [Cholesterol results in increased expression of NFE2L2 mRNA]]
CTD PMID:28555106 PMID:30672636 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 protein]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 mRNA]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 protein]] CTD PMID:29423081 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [Cholesterol results in increased expression of NQO1 mRNA]] CTD PMID:30672636 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G NR1H2 nuclear receptor subfamily 1 group H member 2 multiple interactions ISO alpha-Linolenic Acid binds to and results in increased activity of NR1H2 protein CTD PMID:16731579 NCBI chr19:50,376,457...50,383,388
Ensembl chr19:50,329,653...50,383,388
JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 multiple interactions
affects binding
EXP alpha-Linolenic Acid inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]
alpha-Linolenic Acid binds to NR1H4 protein
CTD PMID:15307955 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414
JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 multiple interactions ISO [Glucose deficiency co-treated with alpha-Linolenic Acid] results in increased expression of PCK1 mRNA CTD PMID:8536680 NCBI chr20:57,561,110...57,568,121
Ensembl chr20:57,561,080...57,568,121
JBrowse link
G PLIN2 perilipin 2 increases expression ISO alpha-Linolenic Acid results in increased expression of PLIN2 mRNA; alpha-Linolenic Acid results in increased expression of PLIN2 protein CTD PMID:16489205 NCBI chr 9:19,108,391...19,127,518
Ensembl chr 9:19,108,375...19,149,290
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions
affects abundance
increases expression
ISO
EXP
alpha-Linolenic Acid binds to and results in increased activity of PPARA protein
PPARA protein affects the abundance of alpha-Linolenic Acid
alpha-Linolenic Acid results in increased expression of PPARA mRNA
alpha-Linolenic Acid binds to and results in increased activity of PPARA protein; Calcitriol promotes the reaction [alpha-Linolenic Acid results in increased expression of PPARA mRNA]
alpha-Linolenic Acid binds to and results in increased activity of PPARA protein; Diethylhexyl Phthalate inhibits the reaction [PPARA protein affects the abundance of alpha-Linolenic Acid]
CTD PMID:10403814 PMID:16731579 PMID:18154422 PMID:19667161 PMID:23619606 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PPARD peroxisome proliferator activated receptor delta increases expression
multiple interactions
EXP
ISO
alpha-Linolenic Acid results in increased expression of PPARD mRNA; Calcitriol results in increased expression of [alpha-Linolenic Acid results in increased expression of PPARD mRNA]
alpha-Linolenic Acid binds to and results in increased activity of PPARB protein
CTD PMID:16731579 PMID:19667161 NCBI chr 6:35,342,558...35,428,180
Ensembl chr 6:35,342,558...35,428,191
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma increases expression
increases activity
multiple interactions
ISO
EXP
alpha-Linolenic Acid results in increased expression of PPARG mRNA
alpha-Linolenic Acid results in increased activity of PPARG protein
alpha-Linolenic Acid binds to and results in increased activity of PPARG protein
CTD PMID:16731579 PMID:18154422 PMID:20696231 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression
decreases expression
EXP
ISO
alpha-Linolenic Acid results in increased expression of PTGS2 mRNA
alpha-Linolenic Acid results in increased expression of PTGS2 protein
alpha-Linolenic Acid results in decreased expression of PTGS2 mRNA
CTD PMID:14563831 PMID:17092368 PMID:22476691 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G RXRA retinoid X receptor alpha multiple interactions
affects binding
EXP
ISO
alpha-Linolenic Acid binds to and results in increased activity of RXRA protein
alpha-Linolenic Acid binds to RXRA protein
CTD PMID:16258897 PMID:16731579 NCBI chr 9:134,326,455...134,440,585
Ensembl chr 9:134,317,098...134,440,585
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 decreases expression ISO alpha-Linolenic Acid results in decreased expression of SREBF1 mRNA CTD PMID:14563831 NCBI chr17:17,811,334...17,837,017
Ensembl chr17:17,810,399...17,837,011
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]; alpha-Linolenic Acid inhibits the reaction [Cholesterol promotes the reaction [Particulate Matter results in increased expression of TNF protein]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]] CTD PMID:29423081 PMID:30672636 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 multiple interactions ISO [alpha-Linolenic Acid co-treated with Phorbol 12,13-Dibutyrate] results in increased activity of TRPV1 protein CTD PMID:17038422 NCBI chr17:3,565,446...3,609,411
Ensembl chr17:3,565,444...3,609,411
JBrowse link
G UCP2 uncoupling protein 2 increases expression ISO alpha-Linolenic Acid results in increased expression of UCP2 mRNA CTD PMID:11341955 NCBI chr11:73,974,671...73,983,202
Ensembl chr11:73,974,672...73,983,246
Ensembl chr11:73,974,672...73,983,246
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions ISO alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 protein]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 protein]] CTD PMID:29423081 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045
JBrowse link
G VDR vitamin D receptor increases expression
multiple interactions
EXP alpha-Linolenic Acid results in increased expression of VDR mRNA
[Calcitriol co-treated with alpha-Linolenic Acid] results in increased expression of VDR mRNA
CTD PMID:19667161 NCBI chr12:47,841,537...47,905,022
Ensembl chr12:47,841,537...47,943,048
JBrowse link
1,2,3-trilinolenoylglycerol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 decreases expression ISO trilinolenin results in decreased expression of ABCA1 mRNA CTD PMID:18356535 NCBI chr 9:104,781,006...104,928,232
Ensembl chr 9:104,781,006...104,928,155
JBrowse link
G ABCG5 ATP binding cassette subfamily G member 5 decreases expression ISO trilinolenin results in decreased expression of ABCG5 mRNA CTD PMID:18356535 NCBI chr 2:43,806,154...43,838,840
Ensembl chr 2:43,812,472...43,838,865
JBrowse link
G ABCG8 ATP binding cassette subfamily G member 8 decreases expression ISO trilinolenin results in decreased expression of ABCG8 mRNA CTD PMID:18356535 NCBI chr 2:43,831,942...43,882,988
Ensembl chr 2:43,831,942...43,882,988
JBrowse link
G CYP27A1 cytochrome P450 family 27 subfamily A member 1 decreases expression ISO trilinolenin results in decreased expression of CYP27A1 mRNA CTD PMID:18356535 NCBI chr 2:218,781,733...218,815,293
Ensembl chr 2:218,781,749...218,815,293
JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO trilinolenin results in increased expression of HMGCR mRNA CTD PMID:18356535 NCBI chr 5:75,336,334...75,362,116
Ensembl chr 5:75,336,329...75,362,101
Ensembl chr 5:75,336,329...75,362,101
JBrowse link
G MTTP microsomal triglyceride transfer protein increases expression ISO trilinolenin results in increased expression of MTTP mRNA CTD PMID:18356535 NCBI chr 4:99,564,130...99,623,997
Ensembl chr 4:99,563,761...99,623,999
Ensembl chr 4:99,563,761...99,623,999
JBrowse link
G NPC1L1 NPC1 like intracellular cholesterol transporter 1 decreases expression ISO trilinolenin results in decreased expression of NPC1L1 mRNA CTD PMID:18356535 NCBI chr 7:44,512,440...44,541,651
Ensembl chr 7:44,512,535...44,541,330
Ensembl chr 7:44,512,535...44,541,330
JBrowse link
cholesteryl linolenate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LIPC lipase C, hepatic type multiple interactions ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl linolenate CTD PMID:24777581 NCBI chr15:58,410,457...58,569,844
Ensembl chr15:58,410,569...58,569,844
JBrowse link
G LIPG lipase G, endothelial type multiple interactions
increases abundance
ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl linolenate
LIPG gene mutant form results in increased abundance of cholesteryl linolenate
CTD PMID:24777581 NCBI chr18:49,560,699...49,599,185
Ensembl chr18:49,560,699...49,599,185
JBrowse link
soybean oil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 affects expression ISO Soybean Oil affects the expression of ABCB11 mRNA CTD PMID:15770074 NCBI chr 2:168,915,468...169,031,396
Ensembl chr 2:168,915,498...169,031,324
JBrowse link
G ABCB4 ATP binding cassette subfamily B member 4 affects expression ISO Soybean Oil affects the expression of ABCB4 mRNA CTD PMID:15770074 NCBI chr 7:87,398,988...87,476,722
Ensembl chr 7:87,401,697...87,480,435
Ensembl chr 7:87,401,697...87,480,435
JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 affects expression ISO Soybean Oil affects the expression of ABCC1 mRNA CTD PMID:15770074 NCBI chr16:15,949,616...16,143,062
Ensembl chr16:15,949,577...16,143,074
Ensembl chr16:15,949,577...16,143,074
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 affects expression ISO Soybean Oil affects the expression of ABCC2 mRNA CTD PMID:15770074 NCBI chr10:99,782,602...99,853,741
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G ABCC5 ATP binding cassette subfamily C member 5 affects expression ISO Soybean Oil affects the expression of ABCC5 mRNA CTD PMID:15770074 NCBI chr 3:183,919,934...184,018,010
Ensembl chr 3:183,919,934...184,017,939
JBrowse link
G ABCC6 ATP binding cassette subfamily C member 6 affects expression ISO Soybean Oil affects the expression of ABCC6 mRNA CTD PMID:15770074 NCBI chr16:16,149,565...16,223,617
Ensembl chr16:16,148,928...16,223,522
Ensembl chr16:16,148,928...16,223,522
JBrowse link
G ACAT1 acetyl-CoA acetyltransferase 1 decreases activity ISO Soybean Oil results in decreased activity of ACAT1 protein CTD PMID:12559476 NCBI chr11:108,116,705...108,148,822
Ensembl chr11:108,116,695...108,147,603
JBrowse link
G BCL2 BCL2 apoptosis regulator increases expression ISO Soybean Oil results in increased expression of BCL2 protein CTD PMID:15309441 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CAT catalase increases activity ISO Soybean Oil results in increased activity of CAT protein CTD PMID:12781854 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCND1 cyclin D1 increases expression ISO Soybean Oil results in increased expression of CCND1 mRNA CTD PMID:21088903 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CYP4A22 cytochrome P450 family 4 subfamily A member 22 affects expression ISO Soybean Oil affects the expression of CYP4A1 mRNA CTD PMID:16079505 NCBI chr 1:47,137,441...47,149,738
Ensembl chr 1:47,137,435...47,149,735
JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 increases activity ISO Soybean Oil results in increased activity of CYP7A1 protein CTD PMID:12559476 NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163
JBrowse link
G GSTP1 glutathione S-transferase pi 1 multiple interactions ISO Soybean Oil promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GSTP1 mRNA]; Soybean Oil promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GSTP1 protein] CTD PMID:11600134 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase increases activity ISO Soybean Oil results in increased activity of HMGCR protein CTD PMID:12559476 NCBI chr 5:75,336,334...75,362,116
Ensembl chr 5:75,336,329...75,362,101
Ensembl chr 5:75,336,329...75,362,101
JBrowse link
G IL12B interleukin 12B decreases expression ISO Soybean Oil results in decreased expression of IL12B mRNA CTD PMID:10065739 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
JBrowse link
G SLC22A1 solute carrier family 22 member 1 affects expression ISO Soybean Oil affects the expression of SLC22A1 mRNA CTD PMID:15770074 NCBI chr 6:160,121,808...160,160,590
Ensembl chr 6:160,121,815...160,158,718
JBrowse link
G SLC22A7 solute carrier family 22 member 7 affects expression ISO Soybean Oil affects the expression of SLC22A7 mRNA CTD PMID:15770074 NCBI chr 6:43,295,710...43,305,538
Ensembl chr 6:43,295,694...43,305,538
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24485
    role 24397
      application 23810
        pharmaceutical 23377
          drug 23377
            nutraceutical 13146
              alpha-linolenic acid 71
                (9Z,11R,12Z,15Z)-11-hydroperoxyoctadecatrienoic acid 0
                (9Z,11S,12Z,15Z)-11-hydroperoxyoctadecatrienoic acid 0
                (9Z,12Z,15Z)-octadecatrienamide 0
                (R)-2-hydroperoxy-alpha-linolenic acid 0
                (R)-2-hydroxy-alpha-linolenic acid 0
                1,2,3-trilinolenoylglycerol 7
                1,2-di-(alpha-linolenoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol 0
                1,2-di-[(9Z,12Z,15Z)-octadecatrienoyl]-sn-glycero-3-phosphocholine 0
                1,3-dilinolenoylglycerol 0
                1-(9Z,12Z,15Z)-octadecatrienoyl-2-(7Z,10Z,13Z)-hexadecatrienoyl-3-(beta-D-galactosyl)-sn-glycerol 0
                1-(9Z,12Z,15Z-octadecatrienoyl)-2-hexadecanoyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol 0
                1-[(9Z)-octadecenoyl]-2-[(9Z,12Z,15Z)-octadecatrienoyl]-sn-glycero-3-phosphocholine 0
                1-[(9Z,12Z,15Z)-octadecatrienoyl]-2-[(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine 0
                1-alpha-linolenoyl-2-[(11Z)-icosenoyl]-sn-glycerol 0
                1-alpha-linolenoyl-2-[(11Z,14Z)-icosadienoyl]-sn-glycerol 0
                1-alpha-linolenoyl-2-[(5Z,8Z,11Z)-icosatrienoyl]-sn-glycerol 0
                1-alpha-linolenoyl-2-[(8Z,11Z,14Z)-icosatrienoyl]-sn-glycerol 0
                1-alpha-linolenoyl-2-hexadecanoylphosphatidylglycerol 0
                1-alpha-linolenoyl-2-icosanoyl-sn-glycerol 0
                1-alpha-linolenoyl-2-oleoylglycerol + 0
                1-alpha-linolenoylglycerol + 0
                1-heptadecanoyl-2-[(9Z,12Z,15Z)-octadecatrienoyl]-sn-glycero-3-phosphocholine 0
                1-linolenoyl-2-oleoyl-sn-glycero-3-phosphate 0
                1-linolenoyl-sn-glycero-3-phosphate 0
                1-linolenyl-2-linoleyl-PAP 0
                1-oleoyl-2-(alpha-linolenoyl)-sn-glycerol 0
                1-oleoyl-2-linolenoyl-PAP 0
                1-palmitoyl-2-[(9Z,12Z,15Z)-octadecatrienoyl]-sn-glycero-3-phosphocholine 0
                1-stearoyl-2-(alpha-linolenoyl)-sn-glycero-3-phosphocholine 0
                1-tetradecanoyl-2-[(9Z,12Z,15Z)-octadecatrienoyl]-sn-glycero-3-phosphocholine 0
                2,3-dilinolenoyl-sn-glycerol 0
                2-alpha-linolenoylglycerol 0
                N-(9Z,12Z,15Z)-octadeca-9,12,15-trienoyl-(2S)-hydroxyglycine 0
                N-(9Z,12Z,15Z)-octadecatrienoylglycine 0
                alpha-linolenoyl bioconjugate + 0
                alpha-linolenoyl group 0
                alpha-linolenoyl-CoA 0
                alpha-linolenoyl-containing glycerolipid + 0
                alpha-linolenoyl-sn-glycero-3-phosphocholine + 0
                cholesteryl linolenate 2
                ethyl linolenate 0
                linolenic acid anilide 0
                methyl linolenate 0
                soybean oil 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 24485
    subatomic particle 24442
      composite particle 24442
        hadron 24442
          baryon 24442
            nucleon 24442
              atomic nucleus 24442
                atom 24442
                  main group element atom 24300
                    p-block element atom 24300
                      carbon group element atom 24084
                        carbon atom 24047
                          organic molecular entity 24047
                            organic group 22411
                              organic divalent group 22388
                                organodiyl group 22388
                                  carbonyl group 22373
                                    carbonyl compound 22373
                                      carboxylic acid 21372
                                        monocarboxylic acid 20334
                                          fatty acid 18324
                                            unsaturated fatty acid 967
                                              polyunsaturated fatty acid 699
                                                trienoic fatty acid 124
                                                  fatty acid 18:3 110
                                                    octadecatrienoic acid 110
                                                      linolenic acid 107
                                                        alpha-linolenic acid 71
                                                          (9Z,11R,12Z,15Z)-11-hydroperoxyoctadecatrienoic acid 0
                                                          (9Z,11S,12Z,15Z)-11-hydroperoxyoctadecatrienoic acid 0
                                                          (9Z,12Z,15Z)-octadecatrienamide 0
                                                          (R)-2-hydroperoxy-alpha-linolenic acid 0
                                                          (R)-2-hydroxy-alpha-linolenic acid 0
                                                          1,2,3-trilinolenoylglycerol 7
                                                          1,2-di-(alpha-linolenoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol 0
                                                          1,2-di-[(9Z,12Z,15Z)-octadecatrienoyl]-sn-glycero-3-phosphocholine 0
                                                          1,3-dilinolenoylglycerol 0
                                                          1-(9Z,12Z,15Z)-octadecatrienoyl-2-(7Z,10Z,13Z)-hexadecatrienoyl-3-(beta-D-galactosyl)-sn-glycerol 0
                                                          1-(9Z,12Z,15Z-octadecatrienoyl)-2-hexadecanoyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol 0
                                                          1-[(9Z)-octadecenoyl]-2-[(9Z,12Z,15Z)-octadecatrienoyl]-sn-glycero-3-phosphocholine 0
                                                          1-[(9Z,12Z,15Z)-octadecatrienoyl]-2-[(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine 0
                                                          1-alpha-linolenoyl-2-[(11Z)-icosenoyl]-sn-glycerol 0
                                                          1-alpha-linolenoyl-2-[(11Z,14Z)-icosadienoyl]-sn-glycerol 0
                                                          1-alpha-linolenoyl-2-[(5Z,8Z,11Z)-icosatrienoyl]-sn-glycerol 0
                                                          1-alpha-linolenoyl-2-[(8Z,11Z,14Z)-icosatrienoyl]-sn-glycerol 0
                                                          1-alpha-linolenoyl-2-hexadecanoylphosphatidylglycerol 0
                                                          1-alpha-linolenoyl-2-icosanoyl-sn-glycerol 0
                                                          1-alpha-linolenoyl-2-oleoylglycerol + 0
                                                          1-alpha-linolenoylglycerol + 0
                                                          1-heptadecanoyl-2-[(9Z,12Z,15Z)-octadecatrienoyl]-sn-glycero-3-phosphocholine 0
                                                          1-linolenoyl-2-oleoyl-sn-glycero-3-phosphate 0
                                                          1-linolenoyl-sn-glycero-3-phosphate 0
                                                          1-linolenyl-2-linoleyl-PAP 0
                                                          1-oleoyl-2-(alpha-linolenoyl)-sn-glycerol 0
                                                          1-oleoyl-2-linolenoyl-PAP 0
                                                          1-palmitoyl-2-[(9Z,12Z,15Z)-octadecatrienoyl]-sn-glycero-3-phosphocholine 0
                                                          1-stearoyl-2-(alpha-linolenoyl)-sn-glycero-3-phosphocholine 0
                                                          1-tetradecanoyl-2-[(9Z,12Z,15Z)-octadecatrienoyl]-sn-glycero-3-phosphocholine 0
                                                          2,3-dilinolenoyl-sn-glycerol 0
                                                          2-alpha-linolenoylglycerol 0
                                                          N-(9Z,12Z,15Z)-octadeca-9,12,15-trienoyl-(2S)-hydroxyglycine 0
                                                          N-(9Z,12Z,15Z)-octadecatrienoylglycine 0
                                                          alpha-linolenoyl bioconjugate + 0
                                                          alpha-linolenoyl group 0
                                                          alpha-linolenoyl-CoA 0
                                                          alpha-linolenoyl-containing glycerolipid + 0
                                                          alpha-linolenoyl-sn-glycero-3-phosphocholine + 0
                                                          cholesteryl linolenate 2
                                                          ethyl linolenate 0
                                                          linolenic acid anilide 0
                                                          methyl linolenate 0
                                                          soybean oil 17
paths to the root