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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:xylene
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Accession:CHEBI:27338 term browser browse the term
Synonyms:related_synonym: Dimethylbenzol;   Formula=C8H10;   Xylol;   Xylole;   dimethylbenzene;   methyl toluene;   methyltoluene;   xileno;   xilenos;   xylenes
 xref: CAS:1330-20-7;   KEGG:C19551;   Wikipedia:Xylene


show annotations for term's descendants           Sort by:
2,4-xylenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity ISO 2,4-dimethylphenol results in increased activity of TRPA1 protein CTD PMID:29658714 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 increases activity ISO 2,4-dimethylphenol results in increased activity of TRPV3 protein CTD PMID:29658714 NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296 		JBrowse link
2,5-xylenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity ISO 2,5-xylenol results in increased activity of TRPA1 protein CTD PMID:29658714 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 increases activity ISO 2,5-xylenol results in increased activity of TRPV3 protein CTD PMID:29658714 NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296 		JBrowse link
3,4-xylenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity ISO 3,4-dimethylphenol results in increased activity of TRPA1 protein CTD PMID:29658714 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 increases activity ISO 3,4-dimethylphenol results in increased activity of TRPV3 protein CTD PMID:29658714 NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296 		JBrowse link
3,5-xylenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases oxidation
multiple interactions		 ISO CYP1A2 protein results in increased oxidation of 3,5-xylenol analog
[CYP1A2 protein results in increased oxidation of 3,5-xylenol analog] which results in increased abundance of 4-(methylsulfinyl)phenol analog		 CTD PMID:27665777 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases oxidation		 ISO [CYP2B6 protein results in increased oxidation of 3,5-xylenol analog] which results in increased abundance of 4-(methylsulfinyl)phenol analog CTD PMID:27665777 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions
increases oxidation		 ISO [CYP2C19 protein results in increased oxidation of 3,5-xylenol analog] which results in increased abundance of 4-(methylsulfinyl)phenol analog CTD PMID:27665777 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
increases oxidation		 ISO [CYP2D6 protein results in increased oxidation of 3,5-xylenol analog] which results in increased abundance of 4-(methylsulfinyl)phenol analog CTD PMID:27665777 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO 3,5-xylenol analog results in increased activity of NR1I2 protein CTD PMID:27665777 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity ISO 3,5-xylenol results in increased activity of TRPA1 protein CTD PMID:29658714 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 increases activity ISO 3,5-xylenol results in increased activity of TRPV3 protein CTD PMID:29658714 NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296 		JBrowse link
4-chloro-3,5-dimethylphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO chloroxylenol inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein] CTD PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO chloroxylenol binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO chloroxylenol binds to and results in increased activity of ESR2 protein CTD PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO chloroxylenol binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO chloroxylenol binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Scn4a sodium voltage-gated channel alpha subunit 4 affects activity
multiple interactions		 ISO chloroxylenol affects the activity of SCN4A protein polymorphism
chloroxylenol binds to and results in decreased activity of SCN4A protein		 CTD PMID:11282107 PMID:14662728 NCBI chr10:91,246,936...91,296,670
Ensembl chr10:91,246,936...91,296,545 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO chloroxylenol binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
m-xylene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member increases expression ISO 3-xylene results in increased expression of ALDH2 mRNA CTD PMID:33269480 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Aldh3b1 aldehyde dehydrogenase 3 family, member B1 increases expression ISO 3-xylene results in increased expression of ALDH3B1 mRNA CTD PMID:33269480 NCBI chr 1:201,145,309...201,162,675
Ensembl chr 1:201,145,309...201,163,921 		JBrowse link
G Cat catalase decreases activity
decreases expression		 EXP 3-xylene results in decreased activity of CAT protein
3-xylene results in decreased expression of CAT mRNA		 CTD PMID:12765247 PMID:12815608 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cbr1 carbonyl reductase 1 increases expression EXP 3-xylene results in increased expression of CBR1 mRNA CTD PMID:12815608 NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
increases secretion		 ISO
EXP		 3-xylene results in increased expression of CCL2 protein
3-xylene results in increased secretion of MCP1 protein		 CTD PMID:15902427 PMID:17993253 PMID:33269480 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cdo1 cysteine dioxygenase type 1 decreases expression EXP 3-xylene results in decreased expression of CDO1 mRNA CTD PMID:12815608 NCBI chr18:39,432,473...39,447,253
Ensembl chr18:39,432,474...39,447,296 		JBrowse link
G Chrna10 cholinergic receptor nicotinic alpha 10 subunit multiple interactions ISO 3-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]] CTD PMID:18602458 NCBI chr 1:156,487,279...156,494,277
Ensembl chr 1:156,487,279...156,491,476 		JBrowse link
G Chrna9 cholinergic receptor nicotinic alpha 9 subunit multiple interactions ISO 3-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]] CTD PMID:18602458 NCBI chr14:42,235,218...42,241,939
Ensembl chr14:42,235,226...42,242,192 		JBrowse link
G Clu clusterin increases expression EXP 3-xylene results in increased expression of CLU mRNA CTD PMID:12815608 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Cyb5a cytochrome b5 type A decreases expression EXP 3-xylene results in decreased expression of CYB5A mRNA CTD PMID:12815608 NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
affects activity		 EXP 3-xylene results in increased expression of CYP1A1 protein
3-xylene affects the activity of CYP1A1 protein		 CTD PMID:8135039 PMID:8296328 PMID:15204773 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
increases metabolic processing		 ISO
EXP		 furafylline inhibits the reaction [CYP1A2 protein results in increased metabolism of 3-xylene]
3-xylene results in decreased activity of CYP1A2 protein		 CTD PMID:8558417 PMID:8598570 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 affects activity EXP 3-xylene affects the activity of CYP2A1 protein CTD PMID:15204773 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 affects activity
decreases activity
increases expression
multiple interactions		 EXP 3-xylene affects the activity of CYP2B1 protein
3-xylene results in decreased activity of CYP2B1 protein
3-xylene results in increased expression of CYP2B1 protein
[3-xylene results in decreased activity of CYP2B1 protein] which affects the metabolism of Benzo(a)pyrene		 CTD PMID:1949897 PMID:8135039 PMID:8296328 PMID:8598570 PMID:12791539 More... NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression
increases metabolic processing		 EXP 3-xylene results in increased expression of CYP2B2 protein
CYP2B2 protein results in increased metabolism of 3-xylene		 CTD PMID:3705085 PMID:8135039 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP 3-xylene results in decreased expression of CYP2C mRNA CTD PMID:12815608 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing
increases expression
affects activity
multiple interactions
decreases activity
increases activity
increases oxidation
increases hydrolysis		 ISO
EXP		 CYP2E1 protein results in increased metabolism of 3-xylene
3-xylene results in increased expression of CYP2E1 mRNA
3-xylene results in increased expression of CYP2E1 protein
3-xylene affects the activity of CYP2E1 protein
3-xylene promotes the reaction [CYP2E1 protein results in increased metabolism of Methylene Chloride]
3-xylene results in decreased activity of CYP2E1 protein
Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of 3-xylene]
3-xylene results in increased activity of CYP2E1 protein
CYP2E1 protein results in increased oxidation of 3-xylene
CYP2E1 protein results in increased hydrolysis of 3-xylene		 CTD PMID:8517779 PMID:8558417 PMID:8598570 PMID:8889796 PMID:10353308 More... NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 decreases activity
affects activity		 EXP 3-xylene results in decreased activity of CYP4B1 protein
3-xylene affects the activity of CYP4B1 protein		 CTD PMID:8598570 PMID:12791539 PMID:15204773 NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression ISO 3-xylene results in increased expression of EPHX1 mRNA CTD PMID:33269480 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression EXP 3-xylene results in decreased expression of HMGCR mRNA CTD PMID:12815608 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hspb6 heat shock protein family B (small) member 6 decreases expression EXP 3-xylene results in decreased expression of HSPB6 mRNA CTD PMID:12815608 NCBI chr 1:85,806,898...85,809,072
Ensembl chr 1:85,806,146...85,809,071 		JBrowse link
G Il15 interleukin 15 decreases expression EXP 3-xylene results in decreased expression of IL15 mRNA CTD PMID:12815608 NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820 		JBrowse link
G Il18 interleukin 18 decreases expression EXP 3-xylene results in decreased expression of IL18 mRNA CTD PMID:12815608 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1a interleukin 1 alpha increases expression EXP 3-xylene results in increased expression of IL1A protein CTD PMID:12717741 PMID:15902427 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Kng1 kininogen 1 increases expression EXP 3-xylene results in increased expression of KNG1 mRNA CTD PMID:12815608 NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP 3-xylene results in increased expression of MYC mRNA CTD PMID:12815608 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP 3-xylene results in increased expression of NOS2 protein CTD PMID:12717741 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression EXP 3-xylene results in decreased expression of PPARG mRNA CTD PMID:12815608 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases expression EXP 3-xylene results in decreased expression of SULT1A1 mRNA CTD PMID:12815608 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 decreases expression EXP 3-xylene results in decreased expression of TGFB3 mRNA CTD PMID:12815608 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564 		JBrowse link
G Tnf tumor necrosis factor increases expression EXP 3-xylene results in increased expression of TNF protein CTD PMID:15902427 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Top2b DNA topoisomerase II beta decreases expression EXP 3-xylene results in decreased expression of TOP2B mRNA CTD PMID:12815608 NCBI chr15:9,051,340...9,111,721
Ensembl chr15:9,051,341...9,112,085 		JBrowse link
musk xylene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
increases activity		 EXP musk xylene results in increased expression of CYP1A1 protein
musk xylene results in increased activity of CYP1A1 protein		 CTD PMID:10630706 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
increases activity		 EXP
ISO		 musk xylene results in increased expression of CYP1A2 protein
musk xylene metabolite results in increased expression of CYP1A2 mRNA; musk xylene results in increased expression of CYP1A2 mRNA
musk xylene results in increased activity of CYP1A2 protein		 CTD PMID:9397191 PMID:10630706 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 affects activity
increases expression		 EXP musk xylene affects the activity of CYP2B1 protein
musk xylene results in increased expression of CYP2B1 mRNA; musk xylene results in increased expression of CYP2B1 protein		 CTD PMID:10630706 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 affects activity
increases expression		 EXP musk xylene affects the activity of CYP2B2 protein
musk xylene results in increased expression of CYP2B2 protein		 CTD PMID:10630706 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases activity
increases expression		 EXP musk xylene results in increased activity of CYP3A2 protein
musk xylene results in increased expression of CYP3A2 protein		 CTD PMID:10630706 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases activity
increases expression		 EXP musk xylene results in increased activity of CYP3A23-3A1 protein
musk xylene results in increased expression of CYP3A23-3A1 protein		 CTD PMID:10630706 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
o-xylene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2a1 BCL2-related protein A1 increases expression ISO 2-xylene results in increased expression of BCL2A1 mRNA CTD PMID:20359517 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998 		JBrowse link
G Bcl6 BCL6, transcription repressor increases expression ISO 2-xylene results in increased expression of BCL6 mRNA CTD PMID:20359517 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases expression ISO 2-xylene results in increased expression of BIRC3 mRNA CTD PMID:20359517 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Btg1 BTG anti-proliferation factor 1 increases expression ISO 2-xylene results in increased expression of BTG1 mRNA CTD PMID:20359517 NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649 		JBrowse link
G Chrna10 cholinergic receptor nicotinic alpha 10 subunit multiple interactions ISO 2-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]] CTD PMID:18602458 NCBI chr 1:156,487,279...156,494,277
Ensembl chr 1:156,487,279...156,491,476 		JBrowse link
G Chrna9 cholinergic receptor nicotinic alpha 9 subunit multiple interactions ISO 2-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]] CTD PMID:18602458 NCBI chr14:42,235,218...42,241,939
Ensembl chr14:42,235,226...42,242,192 		JBrowse link
G Cth cystathionine gamma-lyase increases expression ISO 2-xylene results in increased expression of CTH mRNA CTD PMID:20359517 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO 2-xylene results in increased expression of CXCR4 mRNA CTD PMID:20359517 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity EXP 2-xylene results in decreased activity of CYP1A1 protein CTD PMID:7990171 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases expression ISO 2-xylene results in decreased expression of CYP1B1 mRNA CTD PMID:20359517 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity EXP 2-xylene results in decreased activity of CYP2B1 protein CTD PMID:7990171 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing
increases expression
multiple interactions
increases oxidation		 ISO
EXP		 CYP2E1 protein results in increased metabolism of 2-xylene
2-xylene results in increased expression of CYP2E1 protein
Acetone promotes the reaction [2-xylene results in increased expression of CYP2E1 protein]
Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of 2-xylene]
CYP2E1 protein results in increased oxidation of 2-xylene		 CTD PMID:8517779 PMID:8558417 PMID:8996725 PMID:17156750 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Dennd5a DENN domain containing 5A increases expression ISO 2-xylene results in increased expression of DENND5A mRNA CTD PMID:20359517 NCBI chr 1:163,928,183...163,994,207
Ensembl chr 1:163,928,183...163,994,316 		JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression ISO 2-xylene results in increased expression of DNAJB9 mRNA CTD PMID:20359517 NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063 		JBrowse link
G Egr3 early growth response 3 increases expression ISO 2-xylene results in increased expression of EGR3 mRNA CTD PMID:20359517 NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627 		JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 increases expression ISO 2-xylene results in increased expression of ELOVL6 mRNA CTD PMID:20359517 NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186 		JBrowse link
G Evi2a ecotropic viral integration site 2A increases expression ISO 2-xylene results in increased expression of EVI2A mRNA CTD PMID:20359517 NCBI chr10:64,485,760...64,489,660
Ensembl chr10:64,485,200...64,489,843 		JBrowse link
G Filip1l filamin A interacting protein 1-like increases expression ISO 2-xylene results in increased expression of FILIP1L mRNA CTD PMID:20359517 NCBI chr11:42,937,353...43,177,085
Ensembl chr11:42,940,467...43,177,415 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO 2-xylene results in increased expression of GADD45A mRNA CTD PMID:20359517 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Hivep2 HIVEP zinc finger 2 increases expression ISO 2-xylene results in increased expression of HIVEP2 mRNA CTD PMID:20359517 NCBI chr 1:8,358,205...8,555,993
Ensembl chr 1:8,359,289...8,555,993 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [2-xylene results in increased expression of HMOX1 mRNA] CTD PMID:20359517 PMID:21144877 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnrnpll heterogeneous nuclear ribonucleoprotein L-like increases expression ISO 2-xylene results in increased expression of HNRNPLL mRNA CTD PMID:20359517 NCBI chr 6:14,969,953...15,000,574
Ensembl chr 6:14,970,057...14,999,745 		JBrowse link
G Ifit2 interferon-induced protein with tetratricopeptide repeats 2 increases expression ISO 2-xylene results in increased expression of IFIT2 mRNA CTD PMID:20359517 NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635 		JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 increases expression ISO 2-xylene results in increased expression of IFIT3 mRNA CTD PMID:20359517 NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307 		JBrowse link
G Ifngr2 interferon gamma receptor 2 increases expression ISO 2-xylene results in increased expression of IFNGR2 mRNA CTD PMID:20359517 NCBI chr11:30,779,733...30,798,005
Ensembl chr11:30,779,733...30,798,005 		JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 increases expression ISO 2-xylene results in increased expression of MAP3K8 mRNA CTD PMID:20359517 NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216 		JBrowse link
G Mxd1 max dimerization protein 1 increases expression ISO 2-xylene results in increased expression of MXD1 mRNA CTD PMID:20359517 NCBI chr 4:119,097,353...119,118,080
Ensembl chr 4:119,097,353...119,117,751 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 increases expression ISO 2-xylene results in increased expression of NCF2 mRNA CTD PMID:20359517 NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277 		JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 increases expression ISO 2-xylene results in increased expression of NEDD9 mRNA CTD PMID:20359517 NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019 		JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 increases expression ISO 2-xylene results in increased expression of NFAT5 mRNA CTD PMID:20359517 NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675 		JBrowse link
G Nfib nuclear factor I/B increases expression ISO 2-xylene results in increased expression of NFIB mRNA CTD PMID:20359517 NCBI chr 5:96,759,208...96,974,001
Ensembl chr 5:96,764,653...96,975,479 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO 2-xylene results in increased expression of NFKBIA mRNA CTD PMID:20359517 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Peli1 pellino E3 ubiquitin protein ligase 1 increases expression ISO 2-xylene results in increased expression of PELI1 mRNA CTD PMID:20359517 NCBI chr14:95,254,274...95,309,168
Ensembl chr14:95,254,589...95,308,285 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression
multiple interactions		 ISO 2-xylene results in increased expression of PMAIP1 mRNA
Acetylcysteine inhibits the reaction [2-xylene results in increased expression of PMAIP1 mRNA]		 CTD PMID:20359517 PMID:21144877 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Prnp prion protein increases expression ISO 2-xylene results in increased expression of PRNP mRNA CTD PMID:20359517 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937 		JBrowse link
G Ptger2 prostaglandin E receptor 2 increases expression ISO 2-xylene results in increased expression of PTGER2 mRNA CTD PMID:20359517 NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714 		JBrowse link
G Rab8b RAB8B, member RAS oncogene family increases expression ISO 2-xylene results in increased expression of RAB8B mRNA CTD PMID:20359517 NCBI chr 8:67,458,921...67,536,466
Ensembl chr 8:67,458,923...67,536,384 		JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit increases expression ISO 2-xylene results in increased expression of RELB mRNA CTD PMID:20359517 NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507 		JBrowse link
G Rnf149 ring finger protein 149 increases expression ISO 2-xylene results in increased expression of RNF149 mRNA CTD PMID:20359517 NCBI chr 9:41,826,825...41,854,381
Ensembl chr 9:41,830,233...41,854,279 		JBrowse link
G Sesn2 sestrin 2 increases expression ISO 2-xylene results in increased expression of SESN2 mRNA CTD PMID:20359517 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260 		JBrowse link
G Slc38a2 solute carrier family 38, member 2 increases expression ISO 2-xylene results in increased expression of SLC38A2 mRNA CTD PMID:20359517 NCBI chr 7:127,851,267...127,863,482
Ensembl chr 7:127,851,267...127,863,436 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO 2-xylene results in increased expression of SLC7A11 mRNA CTD PMID:20359517 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Stx11 syntaxin 11 increases expression ISO 2-xylene results in increased expression of STX11 mRNA CTD PMID:20359517 NCBI chr 1:7,293,427...7,320,060
Ensembl chr 1:7,289,976...7,320,164 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO 2-xylene results in increased expression of TNFAIP3 mRNA CTD PMID:20359517 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
G Usp18 ubiquitin specific peptidase 18 increases expression ISO 2-xylene results in increased expression of USP18 mRNA CTD PMID:20359517 NCBI chr 4:154,471,634...154,499,154
Ensembl chr 4:154,471,592...154,499,144 		JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO 2-xylene results in increased expression of XBP1 mRNA CTD PMID:20359517 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
G Zc3hav1 zinc finger CCCH-type containing, antiviral 1 increases expression ISO 2-xylene results in increased expression of ZC3HAV1 mRNA CTD PMID:20359517 NCBI chr 4:67,012,129...67,062,428
Ensembl chr 4:67,012,185...67,062,428 		JBrowse link
G Zcchc2 zinc finger CCHC-type containing 2 increases expression ISO 2-xylene results in increased expression of ZCCHC2 mRNA CTD PMID:20359517 NCBI chr13:22,118,677...22,193,626
Ensembl chr13:22,119,568...22,166,373 		JBrowse link
p-xylene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna10 cholinergic receptor nicotinic alpha 10 subunit multiple interactions ISO 4-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]] CTD PMID:18602458 NCBI chr 1:156,487,279...156,494,277
Ensembl chr 1:156,487,279...156,491,476 		JBrowse link
G Chrna9 cholinergic receptor nicotinic alpha 9 subunit multiple interactions ISO 4-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]] CTD PMID:18602458 NCBI chr14:42,235,218...42,241,939
Ensembl chr14:42,235,226...42,242,192 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP 4-xylene results in increased expression of CYP1A1 protein CTD PMID:8135039 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP 4-xylene results in increased expression of CYP2B1 protein CTD PMID:8135039 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP 4-xylene results in increased expression of CYP2B2 protein CTD PMID:8135039 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing
multiple interactions
increases oxidation		 ISO CYP2E1 protein results in increased metabolism of 4-xylene
Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of 4-xylene]
CYP2E1 protein results in increased oxidation of 4-xylene		 CTD PMID:8558417 PMID:17156750 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    chemical entity 19840
      molecular entity 19809
        polyatomic entity 19767
          molecule 19702
            organic molecule 19658
              volatile organic compound 15722
                xylene 88
                  2,4-Dihydroxy-3,6-dimethylbenzaldehyde 0
                  Aculeatusquinone A 0
                  Aculeatusquinone B 0
                  Aculeatusquinone C 0
                  Beta-Orcinol 0
                  Penisclerotiorin A 0
                  m-xylene + 45
                  o-xylene + 50
                  p-xylene + 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    main group molecular entity 19759
                      s-block molecular entity 19628
                        hydrogen molecular entity 19614
                          hydrides 19087
                            organic hydride 18656
                              organic fundamental parent 18656
                                hydrocarbon 18396
                                  cyclic hydrocarbon 17214
                                    monocyclic hydrocarbon 6141
                                      annulene 5792
                                        aromatic annulene 5792
                                          benzene 5796
                                            alkylbenzene 3506
                                              methylbenzene 3370
                                                xylene 88
                                                  2,4-Dihydroxy-3,6-dimethylbenzaldehyde 0
                                                  Aculeatusquinone A 0
                                                  Aculeatusquinone B 0
                                                  Aculeatusquinone C 0
                                                  Beta-Orcinol 0
                                                  Penisclerotiorin A 0
                                                  m-xylene + 45
                                                  o-xylene + 50
                                                  p-xylene + 8
paths to the root