CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: vitamin B6
Accession: CHEBI:27306
browse the term
Synonyms: related_synonym: vitamin B-6; vitamina B6; vitamine B6
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Col2a1
collagen type II alpha 1 chain
multiple interactions
EXP
[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pyridoxic Acid
CTD
PMID:24709313
NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997
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Avp
arginine vasopressin
multiple interactions
EXP
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased secretion of AVP protein]
CTD
PMID:11102496
NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
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Fn1
fibronectin 1
decreases expression
ISO
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid results in decreased expression of FN1 mRNA
CTD
PMID:18210741
NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
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Il6
interleukin 6
multiple interactions
ISO
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Silicon Dioxide analog results in increased expression of IL6 protein]
CTD
PMID:24793913
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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Nox1
NADPH oxidase 1
multiple interactions
ISO
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [NOX1 protein promotes the reaction [glycylphenylalanine 2-naphthylamide results in increased export of Calcium]]
CTD
PMID:24912985
NCBI chr X:104,909,328...104,932,508
Ensembl chr X:104,909,326...104,932,508
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Oxt
oxytocin/neurophysin I prepropeptide
multiple interactions
EXP
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of OXT protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased secretion of OXT protein]
CTD
PMID:11102496
NCBI chr 3:123,106,694...123,107,534
Ensembl chr 3:123,106,694...123,107,534
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P2rx7
purinergic receptor P2X 7
multiple interactions
ISO
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein]
CTD
PMID:21638035
NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
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Parp1
poly (ADP-ribose) polymerase 1
multiple interactions
ISO
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [zinc chloride results in increased expression of PARP1 protein]
CTD
PMID:22253048
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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Alpl
alkaline phosphatase, biomineralization associated
increases abundance
ISO
ALPL gene mutant form results in increased abundance of Pyridoxal Phosphate
CTD
PMID:7550313
NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
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Bcl2
BCL2, apoptosis regulator
decreases expression
EXP
Pyridoxal Phosphate results in decreased expression of BCL2 protein
CTD
PMID:16690808
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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Fn1
fibronectin 1
multiple interactions
EXP
Pyridoxal Phosphate inhibits the reaction [Acetaldehyde results in increased expression of FN1 mRNA]
CTD
PMID:8151099
NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
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Fut8
fucosyltransferase 8
multiple interactions decreases activity
ISO
Fucose analog inhibits the reaction [Pyridoxal Phosphate results in decreased activity of FUT8 protein]
CTD
PMID:12770769
NCBI chr 6:100,305,957...100,537,208
Ensembl chr 6:100,337,226...100,537,224
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Gad1
glutamate decarboxylase 1
affects binding decreases activity increases activity
ISO EXP
Pyridoxal Phosphate binds to GAD1 protein modified form Pyridoxal Phosphate results in decreased activity of GAD1 protein Pyridoxal Phosphate results in increased activity of GAD1 protein
CTD
PMID:171340 PMID:7463050 PMID:15686475
NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
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Gad2
glutamate decarboxylase 2
affects binding
ISO
Pyridoxal Phosphate binds to GAD2 protein; Pyridoxal Phosphate binds to GAD2 protein modified form
CTD
PMID:15686475 PMID:15690345 PMID:15836621
NCBI chr17:89,171,576...89,234,770
Ensembl chr17:89,171,250...89,238,040
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Gh1
growth hormone 1
decreases secretion
EXP
Pyridoxal Phosphate results in decreased secretion of GH1 protein
CTD
PMID:16690808
NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
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Nrip1
nuclear receptor interacting protein 1
multiple interactions
ISO
Pyridoxal Phosphate binds to and results in increased activity of NRIP1 protein
CTD
PMID:17277785
NCBI chr11:14,658,225...14,742,478
Ensembl chr11:14,658,225...14,741,563
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Pdxk
pyridoxal kinase
decreases activity
EXP
Pyridoxal Phosphate results in decreased activity of PDXK protein
CTD
PMID:7463050
NCBI chr20:10,930,651...10,952,194
Ensembl chr20:10,930,518...10,952,391
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Pomc
proopiomelanocortin
decreases secretion
ISO
Pyridoxal Phosphate results in decreased secretion of POMC protein
CTD
PMID:16690808
NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
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Ppara
peroxisome proliferator activated receptor alpha
multiple interactions
EXP
Pyridoxal Phosphate inhibits the reaction [Ethanol results in decreased activity of PPARA protein]
CTD
PMID:11022051
NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
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Prl
prolactin
decreases secretion
EXP
Pyridoxal Phosphate results in decreased secretion of PRL protein
CTD
PMID:16690808
NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
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Gsr
glutathione-disulfide reductase
decreases activity
EXP
Pyridoxamine results in decreased activity of GSR protein
CTD
PMID:24831520
NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
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Ptgs2
prostaglandin-endoperoxide synthase 2
decreases activity
ISO
Pyridoxamine results in decreased activity of PTGS2 protein
CTD
PMID:20041722
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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Sod2
superoxide dismutase 2
increases activity
EXP
Pyridoxamine results in increased activity of SOD2 protein
CTD
PMID:24831520
NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
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Sphk1
sphingosine kinase 1
multiple interactions
EXP
Pyridoxamine inhibits the reaction [Glucose results in increased expression of and results in increased activity of SPHK1 protein]
CTD
PMID:21998146
NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393
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Tgfb1
transforming growth factor, beta 1
multiple interactions
EXP
Pyridoxamine inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]
CTD
PMID:15309289
NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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Tnf
tumor necrosis factor
multiple interactions
EXP
Pyridoxamine inhibits the reaction [Streptozocin results in increased expression of TNF protein]
CTD
PMID:15309289
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
Pyridoxine results in increased expression of BAX mRNA
CTD
PMID:28716455
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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Casp8
caspase 8
increases expression
ISO
Pyridoxine results in increased expression of CASP8 mRNA
CTD
PMID:28716455
NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
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Ppargc1a
PPARG coactivator 1 alpha
increases expression
ISO EXP
Pyridoxine results in increased expression of PPARGC1A mRNA
CTD
PMID:23056435
NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
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Shmt1
serine hydroxymethyltransferase 1
multiple interactions
ISO
Pyridoxine affects the expression of and affects the activity of SHMT1 protein
CTD
PMID:17482557
NCBI chr10:47,030,813...47,059,216
Ensembl chr10:47,031,050...47,059,216
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