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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:uric acid
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Accession:CHEBI:27226 term browser browse the term
Definition:An oxopurine that is the final oxidation product of purine metabolism.
Synonyms:related_synonym: Formula=C5H4N4O3;   uric acids
 xref: HMDB:HMDB0000289;   Wikipedia:Uric_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:30848;   is_conjugate_acid_of CHEBI:46818


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1,3,7,9-tetramethyluric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 multiple interactions EXP 1,3,7,9-tetramethyluric acid inhibits the reaction [[Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in increased expression of CTNNB1 protein] CTD PMID:35872049 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions EXP 1,3,7,9-tetramethyluric acid inhibits the reaction [[Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in increased expression of CYP7A1 protein] CTD PMID:35872049 NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions EXP 1,3,7,9-tetramethyluric acid inhibits the reaction [[Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in increased expression of CYP8B1 protein] CTD PMID:35872049 NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:130,442,503...130,457,689 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP 1,3,7,9-tetramethyluric acid inhibits the reaction [[Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in increased expression of IL1B protein] CTD PMID:35872049 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions EXP 1,3,7,9-tetramethyluric acid inhibits the reaction [[Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in decreased expression of NR1H4 protein] CTD PMID:35872049 NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP 1,3,7,9-tetramethyluric acid inhibits the reaction [[Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in decreased phosphorylation of PRKAA1 protein] CTD PMID:35872049 NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions EXP 1,3,7,9-tetramethyluric acid inhibits the reaction [[Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in decreased phosphorylation of PRKAA2 protein] CTD PMID:35872049 NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:125,042,179...125,108,324 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions EXP 1,3,7,9-tetramethyluric acid inhibits the reaction [[Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in increased expression of SCD mRNA] CTD PMID:35872049 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785 		JBrowse link
G Sirt3 sirtuin 3 multiple interactions EXP 1,3,7,9-tetramethyluric acid inhibits the reaction [[Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in decreased expression of SIRT3 protein] CTD PMID:35872049 NCBI chr 1:205,371,703...205,394,145
Ensembl chr 1:205,371,710...205,394,076 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP 1,3,7,9-tetramethyluric acid inhibits the reaction [[Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in increased expression of TGFB1 protein] CTD PMID:35872049 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP 1,3,7,9-tetramethyluric acid inhibits the reaction [[Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in increased expression of TNF protein] CTD PMID:35872049 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
1-methyluric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Xdh xanthine dehydrogenase multiple interactions ISO [XDH protein alternative form results in increased metabolism of 1-methylxanthine] which results in increased chemical synthesis of 1-methyluric acid CTD PMID:19215233 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350 		JBrowse link
7,9-dihydro-1H-purine-2,6,8(3H)-trione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A1cf APOBEC1 complementation factor affects abundance ISO A1CF gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr 1:229,736,037...229,823,499
Ensembl chr 1:239,149,493...239,236,817 		JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Uric Acid] results in increased expression of ABCB11 mRNA CTD PMID:33749747 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Uric Acid] results in increased expression of ABCC2 mRNA CTD PMID:33749747 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Uric Acid] results in increased expression of ABCC3 mRNA; Uric Acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC3 mRNA] CTD PMID:33749747 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 affects export
multiple interactions 		ISO ABCC4 protein affects the export of Uric Acid
Uric Acid inhibits the reaction [ABCC4 protein affects the transport of Methotrexate] 		CTD PMID:15454390 NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375 		JBrowse link
G Ace angiotensin I converting enzyme multiple interactions
increases expression 		ISO APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of ACE mRNA] CTD PMID:30710622 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Uric Acid] results in decreased expression of ACOX1 mRNA CTD PMID:33749747 NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,905,083...101,930,136 		JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression
multiple interactions 		EXP Uric Acid results in increased expression of ACTA2 mRNA; Uric Acid results in increased expression of ACTA2 protein
IL17A protein affects the reaction [Uric Acid results in increased expression of ACTA2 mRNA]; IL17A protein affects the reaction [Uric Acid results in increased expression of ACTA2 protein] 		CTD PMID:37815028 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Agt angiotensinogen multiple interactions
increases expression 		ISO resveratrol inhibits the reaction [Uric Acid results in increased expression of AGT mRNA]; resveratrol inhibits the reaction [Uric Acid results in increased expression of AGT protein]
Uric Acid results in increased expression of AGT mRNA; Uric Acid results in increased expression of AGT protein
APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGT mRNA]; APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGT protein modified form]
Uric Acid results in increased expression of AGT mRNA; Uric Acid results in increased expression of AGT protein modified form 		CTD PMID:25493383 PMID:30710622 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions
increases expression 		ISO APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGTR1A mRNA] CTD PMID:30710622 NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 increases expression
multiple interactions 		ISO Uric Acid results in increased expression of AGTR2 mRNA
APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGTR2 mRNA] 		CTD PMID:30710622 NCBI chr  X:116,914,320...116,918,504
Ensembl chr  X:116,913,656...116,918,745 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 multiple interactions
increases expression 		ISO acetovanillone inhibits the reaction [Uric Acid results in increased expression of AKR1B1 mRNA] CTD PMID:30651350 NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:63,899,222...63,913,315 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation 		ISO honokiol inhibits the reaction [Uric Acid results in increased phosphorylation of AKT1 protein]; nuciferine analog inhibits the reaction [Uric Acid results in increased phosphorylation of AKT1 protein] CTD PMID:35687986 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Alad aminolevulinate dehydratase multiple interactions ISO Uric Acid affects the reaction [ALAD polymorphism affects the susceptibility to Lead] CTD PMID:16263504 NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:80,977,562...80,988,041 		JBrowse link
G Aldh16a1 aldehyde dehydrogenase 16 family, member A1 affects abundance ISO ALDH16A1 gene SNP affects the abundance of Uric Acid CTD PMID:21983786 NCBI chr 1:104,763,200...104,776,270
Ensembl chr 1:104,763,055...104,776,270 		JBrowse link
G Alpk1 alpha-kinase 1 increases expression
multiple interactions
increases response to substance 		ISO Uric Acid results in increased expression of ALPK1 mRNA
ALPK1 protein promotes the reaction [Uric Acid results in increased secretion of TGFB1 protein]
ALPK1 protein results in increased susceptibility to Uric Acid 		CTD PMID:27542954 NCBI chr 2:218,801,425...218,924,013
Ensembl chr 2:218,780,189...218,921,646 		JBrowse link
G Apln apelin multiple interactions ISO APLN protein modified form inhibits the reaction [Uric Acid results in decreased activity of CAT protein]; APLN protein modified form inhibits the reaction [Uric Acid results in decreased expression of APLNR mRNA]; APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of ACE mRNA]; APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGT mRNA]; APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGT protein modified form]; APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGTR1A mRNA]; APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGTR2 mRNA] CTD PMID:30710622 NCBI chr  X:132,058,739...132,091,518
Ensembl chr  X:132,081,759...132,091,246 		JBrowse link
G Aplnr apelin receptor multiple interactions
decreases expression 		ISO APLN protein modified form inhibits the reaction [Uric Acid results in decreased expression of APLNR mRNA] CTD PMID:30710622 NCBI chr 3:90,624,055...90,627,700
Ensembl chr 3:90,624,012...90,627,908 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Uric Acid; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Uric Acid] CTD PMID:39172838 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971 		JBrowse link
G Aqp1 aquaporin 1 multiple interactions ISO AQP1 mRNA affects the reaction [Uric Acid results in increased secretion of IL1B protein] CTD PMID:21051542 NCBI chr 4:85,812,784...85,824,964
Ensembl chr 4:85,812,784...85,830,504 		JBrowse link
G Aqp9 aquaporin 9 multiple interactions ISO AQP9 mRNA affects the reaction [Uric Acid results in increased secretion of IL1B protein] CTD PMID:21051542 NCBI chr 8:80,678,027...80,718,273
Ensembl chr 8:80,678,030...80,717,240 		JBrowse link
G Arg1 arginase 1 increases expression
multiple interactions 		EXP Uric Acid results in increased expression of ARG1 protein
Colchicine promotes the reaction [Uric Acid results in increased expression of ARG1 protein]; simiaowan promotes the reaction [Uric Acid results in increased expression of ARG1 protein] 		CTD PMID:33894285 NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:22,295,322...22,307,713 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO Uric Acid inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 mRNA] CTD PMID:21703327 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739 		JBrowse link
G Atr ATR serine/threonine kinase multiple interactions
increases phosphorylation 		ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of ATR protein] CTD PMID:23619996 NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:105,306,305...105,403,718 		JBrowse link
G Atxn2 ataxin 2 affects abundance ISO ATXN2 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr12:40,413,657...40,509,895
Ensembl chr12:40,414,904...40,510,473 		JBrowse link
G B3gnt4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 affects abundance ISO B3GNT4 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr12:38,729,653...38,734,911
Ensembl chr12:38,728,889...38,734,744 		JBrowse link
G Baz1b bromodomain adjacent to zinc finger domain, 1B affects abundance ISO BAZ1B gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr12:27,068,541...27,126,511
Ensembl chr12:27,068,541...27,126,511 		JBrowse link
G Brca1 BRCA1, DNA repair associated multiple interactions
decreases expression 		ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of BRCA1 mRNA] CTD PMID:23619996 NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,917,693...86,977,763 		JBrowse link
G Casp1 caspase 1 multiple interactions
increases cleavage
increases expression
increases phosphorylation 		ISO
EXP 		[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Uric Acid] results in increased cleavage of CASP1 protein; [Lipopolysaccharides co-treated with Uric Acid] promotes the reaction [PYCARD protein binds to CASP1 protein binds to IL1B protein binds to NLRP3 protein]; [Lipopolysaccharides co-treated with Uric Acid] results in increased activity of CASP1 protein; [Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of and results in increased activity of CASP1 protein; [Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of CASP1 protein; [Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of CASP1 protein; [Uric Acid affects the susceptibility to [Air Pollutants results in increased abundance of Particulate Matter]] which results in increased activity of CASP1 protein; CASP1 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of H2AX protein]; diallyl trisulfide inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] promotes the reaction [PYCARD protein binds to CASP1 protein binds to IL1B protein binds to NLRP3 protein]]; diallyl trisulfide inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of CASP1 protein]; leojaponin inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of and results in increased activity of CASP1 protein]; leojaponin inhibits the reaction [Uric Acid results in increased cleavage of and results in increased activity of CASP1 protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Uric Acid] results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [Uric Acid results in increased cleavage of CASP1 protein]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of CASP1 protein]; PYCARD protein affects the reaction [Uric Acid results in increased cleavage of CASP1 protein]; Silicon Dioxide analog inhibits the reaction [Uric Acid results in increased cleavage of CASP1 protein]; Uric Acid results in increased cleavage of and results in increased activity of CASP1 protein
[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of CASP1 protein; Apigenin inhibits the reaction [Uric Acid results in increased expression of and results in increased cleavage of and results in increased secretion of CASP1 protein modified form]; CASP1 protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; NLRP3 protein affects the reaction [Uric Acid results in increased cleavage of CASP1 protein]; nuciferine inhibits the reaction [Uric Acid results in increased expression of CASP1 protein]
Uric Acid results in increased expression of CASP1 protein; Uric Acid results in increased expression of CASP1 protein modified form
Uric Acid results in increased phosphorylation of CASP1 protein
Colchicine inhibits the reaction [Uric Acid results in increased expression of and results in increased cleavage of CASP1 protein]; evodiamine inhibits the reaction [Uric Acid results in increased expression of and results in increased cleavage of CASP1 protein]; Uric Acid results in increased expression of and results in increased cleavage of CASP1 protein 		CTD PMID:18403674 PMID:18604214 PMID:23430110 PMID:23619996 PMID:25499818 More... NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275 		JBrowse link
G Cat catalase increases expression
decreases activity
multiple interactions 		ISO Uric Acid results in increased expression of CAT protein
Uric Acid results in decreased activity of CAT protein
APLN protein modified form inhibits the reaction [Uric Acid results in decreased activity of CAT protein] 		CTD PMID:23619996 PMID:30710622 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases secretion
increases expression 		ISO
EXP 		[Fructose co-treated with Uric Acid] results in increased secretion of CCL2 protein; Allopurinol inhibits the reaction [[Fructose co-treated with Uric Acid] results in increased secretion of CCL2 protein]
Uric Acid results in increased secretion of CCL2 protein
Uric Acid results in increased expression of CCL2 protein
Probenecid inhibits the reaction [Uric Acid results in increased expression of CCL2 protein] 		CTD PMID:16113518 PMID:19158351 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccnb1 cyclin B1 decreases expression
multiple interactions 		ISO Uric Acid results in decreased expression of CCNB1 mRNA
NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of CCNB1 mRNA] 		CTD PMID:23619996 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression 		ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of CCND1 mRNA] CTD PMID:23619996 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression 		EXP IL17A protein affects the reaction [Uric Acid results in increased expression of COL1A1 mRNA]; IL17A protein affects the reaction [Uric Acid results in increased expression of COL1A1 protein]
Uric Acid results in increased expression of COL1A1 mRNA; Uric Acid results in increased expression of COL1A1 protein 		CTD PMID:37815028 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uric Acid; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uric Acid]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uric Acid] CTD PMID:24709313 NCBI chr 7:130,977,561...131,006,627
Ensembl chr 7:130,977,561...131,006,627 		JBrowse link
G Cp ceruloplasmin affects activity ISO Uric Acid affects the activity of CP protein CTD PMID:10949969 NCBI chr 2:104,368,336...104,427,119
Ensembl chr 2:104,368,456...104,427,087 		JBrowse link
G Ctsb cathepsin B multiple interactions ISO [Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of CTSB protein CTD PMID:18604214 NCBI chr15:41,565,607...41,586,479
Ensembl chr15:41,565,611...41,586,478 		JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions ISO CYBA protein affects the reaction [Uric Acid results in increased secretion of IL1B protein] CTD PMID:18403674 NCBI chr19:67,396,143...67,404,214
Ensembl chr19:67,396,143...67,404,214 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Uric Acid] results in decreased expression of CYP7A1 mRNA CTD PMID:33749747 NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions
decreases expression 		ISO [1-Naphthylisothiocyanate co-treated with Uric Acid] results in decreased expression of CYP8B1 mRNA
Uric Acid results in decreased expression of CYP8B1 mRNA 		CTD PMID:33749747 NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:130,442,503...130,457,689 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Uric Acid inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of DDIT3 mRNA] CTD PMID:21703327 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Edn1 endothelin 1 multiple interactions
increases expression 		ISO resveratrol inhibits the reaction [Uric Acid results in increased expression of EDN1 mRNA]; resveratrol inhibits the reaction [Uric Acid results in increased expression of EDN1 protein]
Uric Acid results in increased expression of EDN1 mRNA; Uric Acid results in increased expression of EDN1 protein 		CTD PMID:25493383 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687 		JBrowse link
G Fn1 fibronectin 1 increases expression
multiple interactions 		ISO Uric Acid results in increased expression of FN1 mRNA
salinomycin inhibits the reaction [Uric Acid results in increased expression of FN1 mRNA] 		CTD PMID:39222901 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137 		JBrowse link
G Gnai2 G protein subunit alpha i2 multiple interactions EXP Uric Acid inhibits the reaction [Glucose results in decreased expression of GNAI2 protein]; Uric Acid inhibits the reaction [Peroxynitrous Acid results in decreased expression of GNAI2 protein]; Uric Acid inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI2 protein] CTD PMID:16962941 PMID:18055527 PMID:18441196 NCBI chr 8:117,167,045...117,187,652
Ensembl chr 8:117,167,045...117,187,622 		JBrowse link
G Gnai3 G protein subunit alpha i3 multiple interactions EXP Uric Acid inhibits the reaction [Glucose results in decreased expression of GNAI3 protein]; Uric Acid inhibits the reaction [Peroxynitrous Acid results in decreased expression of GNAI3 protein]; Uric Acid inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI3 protein] CTD PMID:16962941 PMID:18055527 PMID:18441196 NCBI chr 2:198,430,920...198,468,874 JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Uric Acid] results in increased expression of GPX2 mRNA CTD PMID:33749747 NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:101,226,745...101,230,862 		JBrowse link
G Gsdmd gasdermin D multiple interactions ISO [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Uric Acid] results in increased cleavage of GSDMD protein; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Uric Acid] results in increased cleavage of GSDMD protein] CTD PMID:36577999 NCBI chr 7:109,423,209...109,427,771
Ensembl chr 7:109,422,910...109,430,722 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Uric Acid] results in increased expression of GSTA2 mRNA CTD PMID:33749747 NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:88,064,616...88,077,092 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Uric Acid] results in increased expression of GSTM3 mRNA CTD PMID:33749747 NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:198,219,647...198,222,731 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 affects abundance ISO GSTT1 protein polymorphism affects the abundance of Uric Acid CTD PMID:23747713 NCBI chr20:12,856,068...12,873,020
Ensembl chr20:12,856,083...12,873,019 		JBrowse link
G H2ax H2A.X variant histone increases phosphorylation
multiple interactions 		ISO Uric Acid results in increased phosphorylation of H2AX protein
CASP1 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of H2AX protein]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of H2AX protein] 		CTD PMID:23619996 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha multiple interactions
decreases expression 		ISO [1-Naphthylisothiocyanate co-treated with Uric Acid] results in decreased expression of HADHA mRNA
Uric Acid results in decreased expression of HADHA mRNA 		CTD PMID:33749747 NCBI chr 6:31,907,801...31,947,434
Ensembl chr 6:31,907,291...31,947,698 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression
multiple interactions 		EXP Uric Acid results in increased expression of HAVCR1 protein
IL17A protein affects the reaction [Uric Acid results in increased expression of HAVCR1 protein] 		CTD PMID:37815028 NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO [Lipopolysaccharides co-treated with Uric Acid] results in increased expression of HIF1A mRNA; diallyl trisulfide inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased expression of HIF1A mRNA] CTD PMID:36796188 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Hlf HLF transcription factor, PAR bZIP family member affects abundance ISO HLF gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr10:75,651,320...75,708,979
Ensembl chr10:75,654,534...75,708,619 		JBrowse link
G Hnf4g hepatocyte nuclear factor 4, gamma affects abundance ISO HNF4G gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr 2:99,792,942...99,943,811
Ensembl chr 2:99,792,942...99,943,811 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor affects abundance ISO IGF1R gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP [Colchicine co-treated with Uric Acid] results in increased expression of IL10 protein; [simiaowan co-treated with Uric Acid] results in increased expression of IL10 protein CTD PMID:33894285 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il17a interleukin 17A multiple interactions
increases expression 		EXP IL17A protein affects the reaction [Uric Acid results in increased expression of ACTA2 mRNA]; IL17A protein affects the reaction [Uric Acid results in increased expression of ACTA2 protein]; IL17A protein affects the reaction [Uric Acid results in increased expression of and results in increased phosphorylation of RELA protein]; IL17A protein affects the reaction [Uric Acid results in increased expression of COL1A1 mRNA]; IL17A protein affects the reaction [Uric Acid results in increased expression of COL1A1 protein]; IL17A protein affects the reaction [Uric Acid results in increased expression of HAVCR1 protein]; IL17A protein affects the reaction [Uric Acid results in increased expression of IL1B mRNA]; IL17A protein affects the reaction [Uric Acid results in increased expression of IL1B protein]; IL17A protein affects the reaction [Uric Acid results in increased expression of IL6 mRNA]; IL17A protein affects the reaction [Uric Acid results in increased expression of IL6 protein]; IL17A protein affects the reaction [Uric Acid results in increased expression of TNF mRNA]; IL17A protein affects the reaction [Uric Acid results in increased expression of TNF protein]
Uric Acid results in increased expression of IL17A protein 		CTD PMID:37815028 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331 		JBrowse link
G Il18 interleukin 18 multiple interactions
increases expression 		EXP Colchicine inhibits the reaction [Uric Acid results in increased expression of IL18 protein]; evodiamine inhibits the reaction [Uric Acid results in increased expression of IL18 protein] CTD PMID:37555854 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
increases secretion 		EXP
ISO 		Colchicine inhibits the reaction [Uric Acid results in increased expression of IL1B protein]; Drugs, Chinese Herbal inhibits the reaction [Uric Acid results in increased expression of IL1B mRNA]; Drugs, Chinese Herbal inhibits the reaction [Uric Acid results in increased expression of IL1B protein]; evodiamine inhibits the reaction [Uric Acid results in increased expression of IL1B protein]; IL17A protein affects the reaction [Uric Acid results in increased expression of IL1B mRNA]; IL17A protein affects the reaction [Uric Acid results in increased expression of IL1B protein]; simiaowan inhibits the reaction [Uric Acid results in increased expression of IL1B protein]
Uric Acid results in increased expression of IL1B mRNA; Uric Acid results in increased expression of IL1B protein
2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride inhibits the reaction [Uric Acid promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; [Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Uric Acid] results in increased expression of IL1B protein; [Uric Acid co-treated with TGFB1 protein] promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Ammonium Chloride inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Apigenin inhibits the reaction [Uric Acid results in increased expression of and results in increased cleavage of and results in increased secretion of IL1B protein]; AQP1 mRNA affects the reaction [Uric Acid results in increased secretion of IL1B protein]; AQP9 mRNA affects the reaction [Uric Acid results in increased secretion of IL1B protein]; CASP1 protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; Chloroquine inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of and results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; diphenyleneiodonium inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; flavone analog inhibits the reaction [Uric Acid results in increased cleavage of and results in increased secretion of IL1B protein]; latrunculin A inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Mercuric Chloride inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine inhibits the reaction [Uric Acid results in increased cleavage of and results in increased secretion of IL1B protein]; NLRP3 protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; nuciferine inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Phloretin inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; PYCARD protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; TGFBR2 protein affects the reaction [Uric Acid promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone analog inhibits the reaction [Uric Acid results in increased cleavage of and results in increased secretion of IL1B protein]; Uric Acid promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Uric Acid results in increased expression of and results in increased cleavage of and results in increased secretion of IL1B protein
[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Uric Acid] results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Uric Acid] promotes the reaction [PYCARD protein binds to CASP1 protein binds to IL1B protein binds to NLRP3 protein]; [Lipopolysaccharides co-treated with Uric Acid] results in increased expression of and results in increased activity of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Uric Acid] results in increased expression of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Uric Acid] results in increased expression of IL1B mRNA; [Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of and results in increased cleavage of IL1B protein; [Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of IL1B protein; acetovanillone inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of IL1B protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Chloroquine inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Chlorquinaldol inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of IL1B protein]; CYBA protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of and results in increased secretion of IL1B protein]; diallyl disulfide inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of IL1B protein]; diallyl trisulfide inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] promotes the reaction [PYCARD protein binds to CASP1 protein binds to IL1B protein binds to NLRP3 protein]]; diallyl trisulfide inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased expression of and results in increased secretion of IL1B protein]; diallyl trisulfide inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased expression of IL1B mRNA]; leojaponin inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of IL1B protein]; leojaponin inhibits the reaction [[Nigericin co-treated with Uric Acid] results in increased secretion of IL1B protein]; leojaponin inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Uric Acid] results in increased secretion of IL1B protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of and results in increased cleavage of IL1B protein]; NLRP3 protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased expression of IL1B protein]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of IL1B protein]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of and results in increased cleavage of IL1B protein]; PYCARD protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; salinomycin inhibits the reaction [Uric Acid results in increased expression of IL1B mRNA]; salinomycin inhibits the reaction [Uric Acid results in increased expression of IL1B protein]; TXN protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; UOX protein inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of IL1B protein]; Uric Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B mRNA] 		CTD PMID:18403674 PMID:18604214 PMID:19655406 PMID:21051542 PMID:23430110 More... NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions ISO 2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride inhibits the reaction [Uric Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1RN protein]]; TGFBR2 protein affects the reaction [Uric Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1RN protein]]; Uric Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1RN protein] CTD PMID:36850003 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression 		ISO
EXP 		salinomycin inhibits the reaction [Uric Acid results in increased expression of IL6 mRNA]; Uric Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 mRNA]; Uric Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 protein]
[Uric Acid co-treated with TGFB1 protein] promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Uric Acid results in increased expression of IL6 mRNA; Uric Acid results in increased expression of IL6 protein
IL17A protein affects the reaction [Uric Acid results in increased expression of IL6 mRNA]; IL17A protein affects the reaction [Uric Acid results in increased expression of IL6 protein] 		CTD PMID:33749747 PMID:36850003 PMID:37815028 PMID:39222901 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Inhbb inhibin subunit beta B affects abundance ISO INHBB gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr13:33,083,671...33,089,373
Ensembl chr13:33,083,671...33,089,609 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 multiple interactions ISO Uric Acid inhibits the reaction [Ethanol results in increased expression of and affects the localization of ITPR1 protein] CTD PMID:17241155 NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:142,743,334...143,066,504 		JBrowse link
G Jak2 Janus kinase 2 increases phosphorylation
multiple interactions 		EXP Uric Acid results in increased phosphorylation of JAK2 protein
Colchicine promotes the reaction [Uric Acid results in increased phosphorylation of JAK2 protein]; simiaowan promotes the reaction [Uric Acid results in increased phosphorylation of JAK2 protein] 		CTD PMID:33894285 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions
increases expression 		ISO salinomycin inhibits the reaction [Uric Acid results in increased expression of KEAP1 mRNA] CTD PMID:39222901 NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042 		JBrowse link
G Khk ketohexokinase increases expression EXP
ISO 		Uric Acid results in increased expression of KHK protein CTD PMID:30651350 NCBI chr 6:31,165,246...31,175,779
Ensembl chr 6:31,165,248...31,175,481 		JBrowse link
G Lepr leptin receptor multiple interactions
increases abundance 		ISO swietenine inhibits the reaction [LEPR gene mutant form results in increased abundance of Uric Acid] CTD PMID:36066211 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215 		JBrowse link
G Maf MAF bZIP transcription factor affects abundance ISO MAF gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr19:60,259,200...60,622,145
Ensembl chr19:60,269,541...60,621,378 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Uric Acid inhibits the reaction [Ammonium Chloride results in increased phosphorylation of MAPK1 protein] CTD PMID:11923223 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Uric Acid inhibits the reaction [Ammonium Chloride results in increased phosphorylation of MAPK3 protein] CTD PMID:11923223 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO Uric Acid results in increased expression of MMP9 mRNA CTD PMID:36850003 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Uric Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased activity of MPO protein] CTD PMID:33749747 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor increases expression
multiple interactions 		ISO Uric Acid results in increased expression of MYD88 protein
nuciferine inhibits the reaction [Uric Acid results in increased expression of MYD88 protein] 		CTD PMID:25499818 NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230 		JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 affects abundance
affects localization 		ISO NFAT5 gene SNP affects the abundance of Uric Acid
Uric Acid affects the localization of NFAT5 protein 		CTD PMID:23263486 PMID:30651350 NCBI chr19:52,108,982...52,196,418
Ensembl chr19:52,109,483...52,196,418 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO salinomycin inhibits the reaction [Uric Acid results in decreased expression of and results in decreased phosphorylation of NFE2L2 protein]; Uric Acid results in decreased expression of and results in decreased phosphorylation of NFE2L2 protein CTD PMID:39222901 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases expression 		EXP Colchicine inhibits the reaction [Uric Acid results in decreased expression of NFKBIA protein]; simiaowan inhibits the reaction [Uric Acid results in decreased expression of NFKBIA protein] CTD PMID:33894285 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions
increases expression
decreases response to substance 		ISO
EXP 		[Lipopolysaccharides co-treated with Uric Acid] affects the localization of NLRP3 protein; [Lipopolysaccharides co-treated with Uric Acid] promotes the reaction [PYCARD protein binds to CASP1 protein binds to IL1B protein binds to NLRP3 protein]; diallyl trisulfide inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] affects the localization of NLRP3 protein]; diallyl trisulfide inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] promotes the reaction [PYCARD protein binds to CASP1 protein binds to IL1B protein binds to NLRP3 protein]]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of BRCA1 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of CCNB1 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of CCND1 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of OGG1 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of POLB mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of PRIM1 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of RAD51 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of RFC3 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of RFC4 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of TTK mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of TYMS mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of XRCC1 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of ATR protein]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of H2AX protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of and results in increased cleavage of IL1B protein]; NLRP3 protein affects the reaction [Uric Acid results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]
Uric Acid results in increased expression of NLRP3 protein
Colchicine inhibits the reaction [Uric Acid results in increased expression of NLRP3 protein]; evodiamine inhibits the reaction [Uric Acid results in increased expression of NLRP3 protein]
[Uric Acid co-treated with Lipopolysaccharides] results in increased activity of NLRP3 protein; NLRP3 protein affects the reaction [Uric Acid results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; nuciferine inhibits the reaction [Uric Acid results in increased expression of NLRP3 protein]
NLRP3 gene mutant form results in decreased susceptibility to Uric Acid 		CTD PMID:18403674 PMID:18604214 PMID:23619996 PMID:25499818 PMID:36796188 More... NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression 		ISO
EXP 		Uric Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of NOS2 mRNA]
Uric Acid results in increased expression of NOS2 protein
Colchicine inhibits the reaction [Uric Acid results in increased expression of NOS2 protein]; simiaowan inhibits the reaction [Uric Acid results in increased expression of NOS2 protein] 		CTD PMID:33749747 PMID:33894285 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nos3 nitric oxide synthase 3 increases abundance ISO NOS3 gene mutant form results in increased abundance of Uric Acid CTD PMID:12947532 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664 		JBrowse link
G Nox3 NADPH oxidase 3 multiple interactions ISO [Lipopolysaccharides co-treated with Uric Acid] results in increased expression of NOX3 mRNA; [Lipopolysaccharides co-treated with Uric Acid] results in increased expression of NOX3 protein; diallyl trisulfide inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased expression of NOX3 mRNA]; diallyl trisulfide inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased expression of NOX3 protein] CTD PMID:36796188 NCBI chr 1:46,643,277...46,708,109
Ensembl chr 1:46,642,564...46,708,109 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO [Lipopolysaccharides co-treated with Uric Acid] results in increased expression of NOX4 mRNA; [Lipopolysaccharides co-treated with Uric Acid] results in increased expression of NOX4 protein; diallyl trisulfide inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased expression of NOX4 mRNA]; diallyl trisulfide inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased expression of NOX4 protein] CTD PMID:36796188 NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Uric Acid] results in increased expression of NQO1 mRNA CTD PMID:33749747 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Uric Acid] results in increased expression of NR0B2 mRNA CTD PMID:33749747 NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:151,063,160...151,066,475 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase decreases expression
multiple interactions 		ISO Uric Acid results in decreased expression of OGG1 mRNA
NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of OGG1 mRNA] 		CTD PMID:23619996 NCBI chr 4:148,030,237...148,037,599
Ensembl chr 4:148,030,349...148,037,604 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Uric Acid inhibits the reaction [sodium arsenite inhibits the reaction [PARP1 protein binds to Zinc]]; Uric Acid inhibits the reaction [sodium arsenite results in decreased activity of and results in increased nitrosation of PARP1 protein] CTD PMID:31152818 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Pawr pro-apoptotic WT1 regulator multiple interactions EXP Uric Acid inhibits the reaction [Nerve Growth Factors deficiency results in increased expression of PAWR mRNA]; Uric Acid inhibits the reaction [Nerve Growth Factors deficiency results in increased expression of PAWR protein] CTD PMID:10428045 NCBI chr 7:45,531,480...45,611,492
Ensembl chr 7:45,531,637...45,611,492 		JBrowse link
G Pml PML nuclear body scaffold multiple interactions ISO PML protein promotes the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased expression of IL1B protein]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of IL1B protein]; Uric Acid promotes the reaction [Lipopolysaccharides results in increased expression of PML protein] CTD PMID:23430110 NCBI chr 8:67,523,164...67,557,801
Ensembl chr 8:67,523,164...67,576,083 		JBrowse link
G Polb DNA polymerase beta multiple interactions
decreases expression 		ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of POLB mRNA] CTD PMID:23619996 NCBI chr16:76,081,903...76,105,174
Ensembl chr16:76,081,864...76,108,180 		JBrowse link
G Pon1 paraoxonase 1 affects abundance ISO PON1 protein polymorphism affects the abundance of Uric Acid CTD PMID:23747713 NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Uric Acid] results in decreased expression of PPARA protein CTD PMID:33749747 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714 		JBrowse link
G Prdx1 peroxiredoxin 1 increases expression ISO Uric Acid results in increased expression of PRDX1 protein CTD PMID:23619996 NCBI chr 5:135,383,906...135,399,504
Ensembl chr 5:135,383,906...135,399,504 		JBrowse link
G Prim1 DNA primase subunit 1 multiple interactions
decreases expression 		ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of PRIM1 mRNA] CTD PMID:23619996 NCBI chr 7:1,031,436...1,047,134 JBrowse link
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 affects abundance ISO PRKAG2 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr 4:10,744,695...10,985,939
Ensembl chr 4:10,744,588...10,985,939 		JBrowse link
G Prkg2 protein kinase cGMP-dependent 2 decreases expression ISO Uric Acid results in decreased expression of PRKG2 mRNA CTD PMID:27542954 NCBI chr14:10,864,020...10,972,617
Ensembl chr14:10,864,186...10,972,614 		JBrowse link
G Psen1 presenilin 1 multiple interactions ISO [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Uric Acid; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Uric Acid] CTD PMID:39172838 NCBI chr 6:109,054,160...109,106,191
Ensembl chr 6:109,060,352...109,106,189 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta multiple interactions
increases phosphorylation 		ISO Apigenin inhibits the reaction [Uric Acid results in increased phosphorylation of PTK2B protein] CTD PMID:29960001 NCBI chr15:44,536,275...44,656,754
Ensembl chr15:44,531,249...44,656,806 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions
increases expression 		ISO
EXP 		[Lipopolysaccharides co-treated with Uric Acid] promotes the reaction [PYCARD protein binds to CASP1 protein binds to IL1B protein binds to NLRP3 protein]; [Lipopolysaccharides co-treated with Uric Acid] promotes the reaction [PYCARD protein binds to PYCARD protein]; diallyl trisulfide inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] promotes the reaction [PYCARD protein binds to CASP1 protein binds to IL1B protein binds to NLRP3 protein]]; diallyl trisulfide inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] promotes the reaction [PYCARD protein binds to PYCARD protein]]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of CASP1 protein]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of and results in increased cleavage of IL1B protein]; PYCARD protein affects the reaction [Uric Acid results in increased cleavage of CASP1 protein]; PYCARD protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]
Uric Acid results in increased expression of PYCARD protein
Colchicine inhibits the reaction [Uric Acid results in increased expression of PYCARD protein]; evodiamine inhibits the reaction [Uric Acid results in increased expression of PYCARD protein]
Apigenin inhibits the reaction [Uric Acid promotes the reaction [PYCARD protein binds to PYCARD protein]]; kaempferol inhibits the reaction [Uric Acid promotes the reaction [PYCARD protein binds to PYCARD protein]]; nuciferine inhibits the reaction [Uric Acid results in increased expression of PYCARD protein]; PYCARD protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; Uric Acid promotes the reaction [PYCARD protein binds to PYCARD protein] 		CTD PMID:18403674 PMID:18604214 PMID:25499818 PMID:29960001 PMID:36796188 More... NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:192,032,124...192,033,419 		JBrowse link
G Rad51 RAD51 recombinase multiple interactions
decreases expression 		ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of RAD51 mRNA] CTD PMID:23619996 NCBI chr 3:126,554,210...126,578,888
Ensembl chr 3:126,554,190...126,579,469 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation 		EXP
ISO 		Colchicine inhibits the reaction [Uric Acid results in increased phosphorylation of RELA protein]; Drugs, Chinese Herbal inhibits the reaction [Uric Acid results in increased localization of and results in increased activity of RELA protein]; IL17A protein affects the reaction [Uric Acid results in increased expression of and results in increased phosphorylation of RELA protein]; simiaowan inhibits the reaction [Uric Acid results in increased phosphorylation of RELA protein]; Uric Acid results in increased expression of and results in increased phosphorylation of RELA protein; Uric Acid results in increased localization of and results in increased activity of RELA protein
nuciferine inhibits the reaction [Uric Acid results in increased phosphorylation of RELA protein]
Uric Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased phosphorylation of RELA protein] 		CTD PMID:19655406 PMID:25499818 PMID:33749747 PMID:33894285 PMID:37815028 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Rfc3 replication factor C subunit 3 multiple interactions
decreases expression 		ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of RFC3 mRNA] CTD PMID:23619996 NCBI chr12:5,836,546...5,847,331
Ensembl chr12:5,836,553...5,847,340 		JBrowse link
G Rfc4 replication factor C subunit 4 multiple interactions
decreases expression 		ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of RFC4 mRNA] CTD PMID:23619996 NCBI chr11:91,254,273...91,268,727
Ensembl chr11:91,254,243...91,268,730 		JBrowse link
G Sfmbt1 Scm-like with four mbt domains 1 affects abundance ISO SFMBT1 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr16:5,889,046...6,009,860
Ensembl chr16:5,897,187...6,011,934 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions ISO Uric Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA] CTD PMID:33749747 NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944 		JBrowse link
G Slc12a2 solute carrier family 12 member 2 multiple interactions EXP Uric Acid inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; Uric Acid inhibits the reaction [Manganese results in increased phosphorylation of and results in increased activity of SLC12A2 protein] CTD PMID:25817889 NCBI chr18:53,546,263...53,614,478
Ensembl chr18:53,546,333...53,614,470 		JBrowse link
G Slc17a3 solute carrier family 17 member 3 affects transport ISO SLC17A3 gene SNP affects the transport of Uric Acid CTD PMID:21282933 NCBI chr17:41,698,679...41,729,057
Ensembl chr17:41,698,680...41,723,329 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 increases import
increases expression
increases uptake
affects transport
multiple interactions
increases export 		ISO
EXP 		SLC22A12 protein results in increased import of Uric Acid
Uric Acid results in increased expression of SLC22A12 protein
SLC22A12 protein results in increased uptake of Uric Acid
SLC22A12 protein affects the transport of Uric Acid
Benzbromarone inhibits the reaction [SLC22A12 protein affects the transport of Uric Acid]; Chlorides affects the reaction [SLC22A12 protein affects the transport of Uric Acid]; Lactic Acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid]; pyrazinoic acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid]
SLC22A12 protein results in increased export of Uric Acid
Benzbromarone inhibits the reaction [SLC22A12 protein affects the transport of Uric Acid]; gluconic acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid]; Lactic Acid affects the reaction [SLC22A12 protein affects the transport of Uric Acid]; Probenecid inhibits the reaction [SLC22A12 protein affects the transport of Uric Acid]; pyrazinoic acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid]
6-hydroxybenzbromarone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; [Chlorine co-treated with perfluoro-n-heptanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]; [Chlorine co-treated with perfluoro-n-nonanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]; [Chlorine co-treated with perfluorodecanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]; [Chlorine co-treated with perfluorooctanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]; [Losartan results in decreased activity of SLC22A12 protein] which results in decreased abundance of Uric Acid; benzarone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Benzbromarone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Chlorine inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]; E 3040 inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Enalapril inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; honokiol inhibits the reaction [Uric Acid results in increased expression of SLC22A12 protein]; Indomethacin inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; nuciferine analog inhibits the reaction [Uric Acid results in increased expression of SLC22A12 protein]; Phenylbutazone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Probenecid inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Salicylates inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Sulfinpyrazone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Uric Acid inhibits the reaction [SLC22A12 protein results in increased uptake of Oxypurinol] 		CTD PMID:14694169 PMID:14747372 PMID:15284287 PMID:16135657 PMID:18670416 More... NCBI chr 1:213,274,266...213,282,793
Ensembl chr 1:213,274,275...213,281,380 		JBrowse link
G Slc22a20 solute carrier family 22 member 20 multiple interactions ISO Uric Acid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate] CTD PMID:16478971 NCBI chr 1:212,686,691...212,703,163
Ensembl chr 1:212,686,691...212,703,163 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions
affects secretion
increases uptake 		ISO
EXP 		4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]; Benzbromarone inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]; gluconic acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]; Glutarates promotes the reaction [SLC22A6 protein results in increased uptake of Uric Acid]; Ketoglutaric Acids inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]; p-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased uptake of Uric Acid]; Probenecid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]; pyrazinoic acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]; Salicylates inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]
SLC22A6 protein affects the secretion of Uric Acid
[Oxonic Acid co-treated with Uric Acid] results in decreased expression of SLC22A6 protein 		CTD PMID:12472777 PMID:19605544 NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 affects transport
multiple interactions 		ISO
EXP 		SLC22A8 protein affects the transport of Uric Acid
[Oxonic Acid co-treated with Uric Acid] results in decreased expression of SLC22A8 protein 		CTD PMID:11306713 PMID:19605544 NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588 		JBrowse link
G Slc2a6 solute carrier family 2 member 6 increases expression
multiple interactions 		ISO Uric Acid results in increased expression of SLC2A6 protein
honokiol inhibits the reaction [Uric Acid results in increased expression of SLC2A6 protein]; nuciferine analog inhibits the reaction [Uric Acid results in increased expression of SLC2A6 protein] 		CTD PMID:35687986 NCBI chr 3:30,746,472...30,753,287
Ensembl chr 3:30,745,995...30,753,287 		JBrowse link
G Slc2a9 solute carrier family 2 member 9 multiple interactions
decreases secretion
affects transport
increases transport
affects abundance 		ISO Benzbromarone inhibits the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid]; Fructose promotes the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid]; Glucose promotes the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid]
SLC2A9 protein results in decreased secretion of Uric Acid
SLC2A9 protein alternative form affects the transport of Uric Acid
Benzbromarone inhibits the reaction [SLC2A9 protein results in increased uptake of Uric Acid]; Losartan inhibits the reaction [SLC2A9 protein results in increased uptake of Uric Acid]; Phloretin inhibits the reaction [SLC2A9 protein results in increased uptake of Uric Acid]
SLC2A9 protein affects the transport of Uric Acid
SLC2A9 gene polymorphism affects the abundance of Uric Acid; SLC2A9 intron SNP affects the abundance of Uric Acid 		CTD PMID:18327256 PMID:18327257 PMID:18842065 PMID:19587147 PMID:22132990 NCBI chr14:76,540,649...76,674,277
Ensembl chr14:76,540,571...76,674,277 		JBrowse link
G Slc51b SLC51 subunit beta multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Uric Acid] results in increased expression of SLC51B mRNA CTD PMID:33749747 NCBI chr 8:74,827,047...74,835,109
Ensembl chr 8:74,827,047...74,835,109 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Uric Acid] results in decreased expression of SLCO1B2 mRNA CTD PMID:33749747 NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083 		JBrowse link
G Smad2 SMAD family member 2 increases phosphorylation ISO Uric Acid results in increased phosphorylation of SMAD2 protein CTD PMID:36850003 NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388 		JBrowse link
G Smad7 SMAD family member 7 decreases expression ISO Uric Acid results in decreased expression of SMAD7 mRNA CTD PMID:36850003 NCBI chr18:71,263,508...71,291,849
Ensembl chr18:71,263,508...71,291,849 		JBrowse link
G Sod1 superoxide dismutase 1 affects activity ISO Uric Acid affects the activity of SOD1 protein CTD PMID:10949969 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Uric Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of SOD2 protein] CTD PMID:21767162 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Sord sorbitol dehydrogenase increases expression ISO Uric Acid results in increased expression of SORD protein CTD PMID:30651350 NCBI chr 3:129,638,282...129,669,727
Ensembl chr 3:129,638,302...129,686,100 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO [Lipopolysaccharides co-treated with Uric Acid] results in increased expression of SQSTM1 protein; diallyl trisulfide inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased expression of SQSTM1 protein] CTD PMID:36796188 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases phosphorylation 		EXP Colchicine promotes the reaction [Uric Acid results in increased phosphorylation of STAT3 protein]; simiaowan promotes the reaction [Uric Acid results in increased phosphorylation of STAT3 protein] CTD PMID:33894285 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Stc1 stanniocalcin 1 affects abundance ISO STC1 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr15:50,709,439...50,720,093
Ensembl chr15:50,709,415...50,720,082 		JBrowse link
G Syk spleen associated tyrosine kinase multiple interactions
increases phosphorylation 		ISO Apigenin inhibits the reaction [Uric Acid results in increased phosphorylation of SYK protein]; N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine inhibits the reaction [Uric Acid results in increased phosphorylation of SYK protein] CTD PMID:29960001 NCBI chr17:12,756,493...12,830,927
Ensembl chr17:12,756,493...12,813,278 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases secretion
multiple interactions
increases expression 		ISO Uric Acid results in increased secretion of TGFB1 protein
[Uric Acid co-treated with TGFB1 protein] promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; [Uric Acid co-treated with TGFB1 protein] promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; ALPK1 protein promotes the reaction [Uric Acid results in increased secretion of TGFB1 protein]
Uric Acid results in increased expression of TGFB1 mRNA 		CTD PMID:27542954 PMID:36850003 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 multiple interactions ISO TGFBR2 protein affects the reaction [Uric Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1RN protein]]; TGFBR2 protein affects the reaction [Uric Acid promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]] CTD PMID:36850003 NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:124,674,986...124,761,469 		JBrowse link
G Tlr4 toll-like receptor 4 increases expression
multiple interactions 		ISO Uric Acid results in increased expression of TLR4 protein
nuciferine inhibits the reaction [Uric Acid results in increased expression of TLR4 protein] 		CTD PMID:25499818 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tmem171 transmembrane protein 171 affects abundance ISO TMEM171 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr 2:31,769,486...31,779,358
Ensembl chr 2:31,769,486...31,780,134 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression 		EXP
ISO 		Colchicine inhibits the reaction [Uric Acid results in increased expression of TNF protein]; Drugs, Chinese Herbal inhibits the reaction [Uric Acid results in increased expression of TNF mRNA]; Drugs, Chinese Herbal inhibits the reaction [Uric Acid results in increased expression of TNF protein]; evodiamine inhibits the reaction [Uric Acid results in increased expression of TNF protein]; IL17A protein affects the reaction [Uric Acid results in increased expression of TNF mRNA]; IL17A protein affects the reaction [Uric Acid results in increased expression of TNF protein]
Uric Acid results in increased expression of TNF mRNA; Uric Acid results in increased expression of TNF protein
salinomycin inhibits the reaction [Uric Acid results in increased expression of TNF mRNA]; salinomycin inhibits the reaction [Uric Acid results in increased expression of TNF protein]; Uric Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF mRNA]; Uric Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF protein] 		CTD PMID:19655406 PMID:33749747 PMID:37555854 PMID:37815028 PMID:39222901 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tp53 tumor protein p53 increases phosphorylation ISO Uric Acid results in increased phosphorylation of TRP53 protein CTD PMID:23619996 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Trim46 tripartite motif-containing 46 affects abundance ISO TRIM46 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr 2:176,939,253...176,952,285
Ensembl chr 2:176,939,253...176,958,364 		JBrowse link
G Ttk Ttk protein kinase multiple interactions
decreases expression 		ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of TTK mRNA] CTD PMID:23619996 NCBI chr 8:93,632,678...93,672,664
Ensembl chr 8:93,634,319...93,672,664 		JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO TXN protein affects the reaction [Uric Acid results in increased secretion of IL1B protein] CTD PMID:18403674 NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307 		JBrowse link
G Txnip thioredoxin interacting protein multiple interactions
increases expression 		EXP Colchicine inhibits the reaction [Uric Acid results in increased expression of TXNIP protein]; evodiamine inhibits the reaction [Uric Acid results in increased expression of TXNIP protein] CTD PMID:37555854 NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:186,781,163...186,785,731 		JBrowse link
G Tyms thymidylate synthetase multiple interactions
decreases expression 		ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of TYMS mRNA] CTD PMID:23619996 NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:120,763,386...120,776,097 		JBrowse link
G Ube2q2 ubiquitin conjugating enzyme E2 Q2 affects abundance ISO UBE2Q2 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr 8:64,414,502...64,474,425
Ensembl chr 8:64,414,301...64,474,418 		JBrowse link
G Vegfa vascular endothelial growth factor A affects abundance ISO VEGFA gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions
increases abundance
increases chemical synthesis 		ISO
EXP 		Fructose promotes the reaction [XDH protein results in increased chemical synthesis of Uric Acid]
XDH protein results in increased abundance of Uric Acid
[2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased activity of XDH protein] which results in decreased abundance of Uric Acid; [bisphenol F results in increased activity of XDH protein] which results in increased abundance of Uric Acid
[1-Naphthylisothiocyanate co-treated with Uric Acid] results in increased expression of XDH mRNA; [bisphenol A results in increased activity of XDH protein] which results in increased chemical synthesis of Uric Acid; [Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of and results in increased activity of XDH protein; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [XDH protein results in increased chemical synthesis of Uric Acid]]; diallyl trisulfide inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of and results in increased activity of XDH protein]; Tetradecanoylphorbol Acetate promotes the reaction [XDH protein results in increased chemical synthesis of Uric Acid] 		CTD PMID:17439425 PMID:19158351 PMID:21920950 PMID:22036979 PMID:31574244 More... NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 multiple interactions
decreases expression 		ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of XRCC1 mRNA] CTD PMID:23619996 NCBI chr 1:89,268,721...89,296,619
Ensembl chr 1:89,268,644...89,296,613 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        biochemical role 20264
          metabolite 20245
            eukaryotic metabolite 19958
              animal metabolite 19803
                mammalian metabolite 19802
                  human metabolite 19220
                    uric acid 145
                      1H-purine-2,6,8-triol 0
                      2,6-dihydroxy-7,9-dihydro-8H-purin-8-one 0
                      5,7-dihydro-1H-purine-2,6,8(9H)-trione + 0
                      6-hydroxy-1H-purine-2,8(7H,9H)-dione 0
                      7,9-dihydro-1H-purine-2,6,8(3H)-trione + 145
                      7H-purine-2,6,8-triol 0
                      9H-purine-2,6,8-triol 0
                      urate salt 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20404
                                organic heterocyclic compound 19388
                                  organic heteropolycyclic compound 18651
                                    organic heterobicyclic compound 17545
                                      imidazopyrimidine 7810
                                        purines 7809
                                          oxopurine 6365
                                            uric acid 145
                                              1H-purine-2,6,8-triol 0
                                              2,6-dihydroxy-7,9-dihydro-8H-purin-8-one 0
                                              5,7-dihydro-1H-purine-2,6,8(9H)-trione + 0
                                              6-hydroxy-1H-purine-2,8(7H,9H)-dione 0
                                              7,9-dihydro-1H-purine-2,6,8(3H)-trione + 145
                                              7H-purine-2,6,8-triol 0
                                              9H-purine-2,6,8-triol 0
                                              urate salt 0
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