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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:uric acid
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Accession:CHEBI:27226 term browser browse the term
Definition:An oxopurine that is the final oxidation product of purine metabolism.
Synonyms:related_synonym: Formula=C5H4N4O3;   uric acids
 xref: HMDB:HMDB0000289;   Wikipedia:Uric_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:30848;   is_conjugate_acid_of CHEBI:46818

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1-methyluric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Xdh xanthine dehydrogenase multiple interactions ISO [XDH protein alternative form results in increased metabolism of 1-methylxanthine] which results in increased chemical synthesis of 1-methyluric acid CTD PMID:19215233 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
7,9-dihydro-1H-purine-2,6,8(3H)-trione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A1cf APOBEC1 complementation factor affects abundance ISO A1CF gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr 1:229,736,037...229,823,499
Ensembl chr 1:229,736,106...229,824,354 		JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Uric Acid] results in increased expression of ABCB11 mRNA CTD PMID:33749747 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Uric Acid] results in increased expression of ABCC2 mRNA CTD PMID:33749747 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Uric Acid] results in increased expression of ABCC3 mRNA; Uric Acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC3 mRNA] CTD PMID:33749747 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 affects export
multiple interactions		 ISO ABCC4 protein affects the export of Uric Acid
Uric Acid inhibits the reaction [ABCC4 protein affects the transport of Methotrexate]		 CTD PMID:15454390 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Ace angiotensin I converting enzyme multiple interactions
increases expression		 ISO APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of ACE mRNA] CTD PMID:30710622 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Uric Acid] results in decreased expression of ACOX1 mRNA CTD PMID:33749747 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Agt angiotensinogen multiple interactions
increases expression		 ISO resveratrol inhibits the reaction [Uric Acid results in increased expression of AGT mRNA]; resveratrol inhibits the reaction [Uric Acid results in increased expression of AGT protein]
Uric Acid results in increased expression of AGT mRNA; Uric Acid results in increased expression of AGT protein modified form
APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGT mRNA]; APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGT protein modified form]		 CTD PMID:25493383 PMID:30710622 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions
increases expression		 ISO APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGTR1A mRNA] CTD PMID:30710622 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 increases expression
multiple interactions		 ISO Uric Acid results in increased expression of AGTR2 mRNA
APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGTR2 mRNA]		 CTD PMID:30710622 NCBI chr  X:112,119,673...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases expression
multiple interactions		 ISO Uric Acid results in increased expression of AKR1B3 mRNA
acetovanillone inhibits the reaction [Uric Acid results in increased expression of AKR1B3 mRNA]		 CTD PMID:30651350 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Alad aminolevulinate dehydratase multiple interactions ISO Uric Acid affects the reaction [ALAD polymorphism affects the susceptibility to Lead] CTD PMID:16263504 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
G Aldh16a1 aldehyde dehydrogenase 16 family, member A1 affects abundance ISO ALDH16A1 gene SNP affects the abundance of Uric Acid CTD PMID:21983786 NCBI chr 1:95,626,727...95,639,808
Ensembl chr 1:95,613,558...95,640,131 		JBrowse link
G Alpk1 alpha-kinase 1 increases expression
multiple interactions
increases response to substance		 ISO Uric Acid results in increased expression of ALPK1 mRNA
ALPK1 protein promotes the reaction [Uric Acid results in increased secretion of TGFB1 protein]
ALPK1 protein results in increased susceptibility to Uric Acid		 CTD PMID:27542954 NCBI chr 2:216,126,939...216,247,180
Ensembl chr 2:216,128,825...216,247,157 		JBrowse link
G Apln apelin multiple interactions ISO APLN protein modified form inhibits the reaction [Uric Acid results in decreased activity of CAT protein]; APLN protein modified form inhibits the reaction [Uric Acid results in decreased expression of APLNR mRNA]; APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of ACE mRNA]; APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGT mRNA]; APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGT protein modified form]; APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGTR1A mRNA]; APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGTR2 mRNA] CTD PMID:30710622 NCBI chr  X:127,180,801...127,213,567
Ensembl chr  X:127,203,823...127,213,391 		JBrowse link
G Aplnr apelin receptor multiple interactions
decreases expression		 ISO APLN protein modified form inhibits the reaction [Uric Acid results in decreased expression of APLNR mRNA] CTD PMID:30710622 NCBI chr 3:70,217,407...70,221,052
Ensembl chr 3:70,217,385...70,221,050 		JBrowse link
G Aqp1 aquaporin 1 multiple interactions ISO AQP1 mRNA affects the reaction [Uric Acid results in increased secretion of IL1B protein] CTD PMID:21051542 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690 		JBrowse link
G Aqp9 aquaporin 9 multiple interactions ISO AQP9 mRNA affects the reaction [Uric Acid results in increased secretion of IL1B protein] CTD PMID:21051542 NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO Uric Acid inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 mRNA] CTD PMID:21703327 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atr ATR serine/threonine kinase multiple interactions
increases phosphorylation		 ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of ATR protein] CTD PMID:23619996 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136 		JBrowse link
G Atxn2 ataxin 2 affects abundance ISO ATXN2 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr12:34,754,132...34,851,175
Ensembl chr12:34,754,137...34,851,479 		JBrowse link
G B3gnt4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 affects abundance ISO B3GNT4 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr12:33,070,221...33,073,904
Ensembl chr12:33,060,416...33,073,854 		JBrowse link
G Baz1b bromodomain adjacent to zinc finger domain, 1B affects abundance ISO BAZ1B gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr12:21,431,985...21,489,956
Ensembl chr12:21,431,985...21,490,426 		JBrowse link
G Brca1 BRCA1, DNA repair associated multiple interactions
decreases expression		 ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of BRCA1 mRNA] CTD PMID:23619996 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Casp1 caspase 1 multiple interactions
increases phosphorylation
increases expression
increases cleavage		 ISO [Lipopolysaccharides co-treated with Uric Acid] results in increased activity of CASP1 protein; [Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of CASP1 protein; CASP1 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of H2AX protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [Uric Acid results in increased cleavage of CASP1 protein]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of CASP1 protein]; PYCARD protein affects the reaction [Uric Acid results in increased cleavage of CASP1 protein]; Silicon Dioxide analog inhibits the reaction [Uric Acid results in increased cleavage of CASP1 protein]
Uric Acid results in increased phosphorylation of CASP1 protein
Uric Acid results in increased expression of CASP1 protein modified form
[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of CASP1 protein; Apigenin inhibits the reaction [Uric Acid results in increased expression of and results in increased cleavage of and results in increased secretion of CASP1 protein modified form]; CASP1 protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; NLRP3 protein affects the reaction [Uric Acid results in increased cleavage of CASP1 protein]		 CTD PMID:18403674 PMID:18604214 PMID:23430110 PMID:23619996 PMID:29960001 More... NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Cat catalase increases expression
multiple interactions
decreases activity		 ISO Uric Acid results in increased expression of CAT protein
APLN protein modified form inhibits the reaction [Uric Acid results in decreased activity of CAT protein]		 CTD PMID:23619996 PMID:30710622 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
increases secretion		 ISO
EXP		 [Fructose co-treated with Uric Acid] results in increased secretion of CCL2 protein; Allopurinol inhibits the reaction [[Fructose co-treated with Uric Acid] results in increased secretion of CCL2 protein]
Probenecid inhibits the reaction [Uric Acid results in increased expression of CCL2 protein]
Uric Acid results in increased secretion of CCL2 protein		 CTD PMID:16113518 PMID:19158351 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccnb1 cyclin B1 decreases expression
multiple interactions		 ISO Uric Acid results in decreased expression of CCNB1 mRNA
NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of CCNB1 mRNA]		 CTD PMID:23619996 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression		 ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of CCND1 mRNA] CTD PMID:23619996 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uric Acid; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uric Acid]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uric Acid] CTD PMID:24709313 NCBI chr 7:129,098,489...129,127,620
Ensembl chr 7:129,098,786...129,127,546 		JBrowse link
G Cp ceruloplasmin affects activity ISO Uric Acid affects the activity of CP protein CTD PMID:10949969 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075 		JBrowse link
G Ctsb cathepsin B multiple interactions ISO [Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of CTSB protein CTD PMID:18604214 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions ISO CYBA protein affects the reaction [Uric Acid results in increased secretion of IL1B protein] CTD PMID:18403674 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Uric Acid] results in decreased expression of CYP7A1 mRNA CTD PMID:33749747 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions
decreases expression		 ISO [1-Naphthylisothiocyanate co-treated with Uric Acid] results in decreased expression of CYP8B1 mRNA
Uric Acid results in decreased expression of CYP8B1 mRNA		 CTD PMID:33749747 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Uric Acid inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of DDIT3 mRNA] CTD PMID:21703327 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Edn1 endothelin 1 multiple interactions
increases expression		 ISO resveratrol inhibits the reaction [Uric Acid results in increased expression of EDN1 mRNA]; resveratrol inhibits the reaction [Uric Acid results in increased expression of EDN1 protein]
Uric Acid results in increased expression of EDN1 mRNA; Uric Acid results in increased expression of EDN1 protein		 CTD PMID:25493383 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Gnai2 G protein subunit alpha i2 multiple interactions EXP Uric Acid inhibits the reaction [Glucose results in decreased expression of GNAI2 protein]; Uric Acid inhibits the reaction [Peroxynitrous Acid results in decreased expression of GNAI2 protein]; Uric Acid inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI2 protein] CTD PMID:16962941 PMID:18055527 PMID:18441196 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979 		JBrowse link
G Gnai3 G protein subunit alpha i3 multiple interactions EXP Uric Acid inhibits the reaction [Glucose results in decreased expression of GNAI3 protein]; Uric Acid inhibits the reaction [Peroxynitrous Acid results in decreased expression of GNAI3 protein]; Uric Acid inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI3 protein] CTD PMID:16962941 PMID:18055527 PMID:18441196 NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742 		JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Uric Acid] results in increased expression of GPX2 mRNA CTD PMID:33749747 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Uric Acid] results in increased expression of GSTA2 mRNA CTD PMID:33749747 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Gsta6 glutathione S-transferase alpha 6 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Uric Acid] results in increased expression of GSTA2 mRNA CTD PMID:33749747 NCBI chr 9:23,743,262...23,806,260
Ensembl chr 9:23,744,288...23,801,131 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Uric Acid] results in increased expression of GSTM3 mRNA CTD PMID:33749747 NCBI chr 2:195,531,627...195,534,562
Ensembl chr 2:195,531,495...195,534,553 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 affects abundance ISO GSTT1 protein polymorphism affects the abundance of Uric Acid CTD PMID:23747713 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G H2ax H2A.X variant histone increases phosphorylation
multiple interactions		 ISO Uric Acid results in increased phosphorylation of H2AX protein
CASP1 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of H2AX protein]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of H2AX protein]		 CTD PMID:23619996 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha multiple interactions
decreases expression		 ISO [1-Naphthylisothiocyanate co-treated with Uric Acid] results in decreased expression of HADHA mRNA
Uric Acid results in decreased expression of HADHA mRNA		 CTD PMID:33749747 NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869 		JBrowse link
G Hlf HLF transcription factor, PAR bZIP family member affects abundance ISO HLF gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr10:75,154,244...75,211,884
Ensembl chr10:75,154,507...75,211,935 		JBrowse link
G Hnf4g hepatocyte nuclear factor 4, gamma affects abundance ISO HNF4G gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr 2:97,885,773...98,036,954
Ensembl chr 2:97,887,432...98,036,592 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor affects abundance ISO IGF1R gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
increases secretion		 EXP
ISO		 Drugs, Chinese Herbal inhibits the reaction [Uric Acid results in increased expression of IL1B mRNA]; Drugs, Chinese Herbal inhibits the reaction [Uric Acid results in increased expression of IL1B protein]
Uric Acid results in increased expression of IL1B mRNA; Uric Acid results in increased expression of IL1B protein
Uric Acid results in increased secretion of IL1B protein
[Lipopolysaccharides co-treated with Uric Acid] results in increased expression of and results in increased activity of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of and results in increased cleavage of IL1B protein; [Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of IL1B protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Chloroquine inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; CYBA protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of and results in increased secretion of IL1B protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of and results in increased cleavage of IL1B protein]; NLRP3 protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased expression of IL1B protein]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of IL1B protein]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of and results in increased cleavage of IL1B protein]; PYCARD protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; TXN protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; UOX protein inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of IL1B protein]; Uric Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B mRNA]
[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Uric Acid] results in increased expression of IL1B protein; Acetylcysteine inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Ammonium Chloride inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Apigenin inhibits the reaction [Uric Acid results in increased expression of and results in increased cleavage of and results in increased secretion of IL1B protein]; AQP1 mRNA affects the reaction [Uric Acid results in increased secretion of IL1B protein]; AQP9 mRNA affects the reaction [Uric Acid results in increased secretion of IL1B protein]; CASP1 protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; Chloroquine inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of and results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; diphenyleneiodonium inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; flavone analog inhibits the reaction [Uric Acid results in increased cleavage of and results in increased secretion of IL1B protein]; latrunculin A inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Mercuric Chloride inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine inhibits the reaction [Uric Acid results in increased cleavage of and results in increased secretion of IL1B protein]; NLRP3 protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; Phloretin inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; PYCARD protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone analog inhibits the reaction [Uric Acid results in increased cleavage of and results in increased secretion of IL1B protein]; Uric Acid results in increased expression of and results in increased cleavage of and results in increased secretion of IL1B protein		 CTD PMID:18403674 PMID:18604214 PMID:19655406 PMID:21051542 PMID:23430110 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Uric Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 mRNA]; Uric Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 protein] CTD PMID:33749747 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Inhbb inhibin subunit beta B affects abundance ISO INHBB gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr13:30,530,860...30,536,566
Ensembl chr13:30,530,860...30,537,832 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 multiple interactions ISO Uric Acid inhibits the reaction [Ethanol results in increased expression of and affects the localization of ITPR1 protein] CTD PMID:17241155 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Khk ketohexokinase increases expression EXP
ISO		 Uric Acid results in increased expression of KHK protein CTD PMID:30651350 NCBI chr 6:25,445,298...25,455,834
Ensembl chr 6:25,445,300...25,455,717 		JBrowse link
G Maf MAF bZIP transcription factor affects abundance ISO MAF gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Uric Acid inhibits the reaction [Ammonium Chloride results in increased phosphorylation of MAPK1 protein] CTD PMID:11923223 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Uric Acid inhibits the reaction [Ammonium Chloride results in increased phosphorylation of MAPK3 protein] CTD PMID:11923223 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Uric Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased activity of MPO protein] CTD PMID:33749747 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 affects abundance
affects localization		 ISO NFAT5 gene SNP affects the abundance of Uric Acid
Uric Acid affects the localization of NFAT5 protein		 CTD PMID:23263486 PMID:30651350 NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions
decreases response to substance		 ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of BRCA1 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of CCNB1 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of CCND1 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of OGG1 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of POLB mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of PRIM1 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of RAD51 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of RFC3 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of RFC4 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of TTK mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of TYMS mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of XRCC1 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of ATR protein]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of H2AX protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of and results in increased cleavage of IL1B protein]; NLRP3 protein affects the reaction [Uric Acid results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]
[Uric Acid co-treated with Lipopolysaccharides] results in increased activity of NLRP3 protein; NLRP3 protein affects the reaction [Uric Acid results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]
NLRP3 gene mutant form results in decreased susceptibility to Uric Acid		 CTD PMID:18403674 PMID:18604214 PMID:23619996 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Uric Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of NOS2 mRNA] CTD PMID:33749747 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 increases abundance ISO NOS3 gene mutant form results in increased abundance of Uric Acid CTD PMID:12947532 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Uric Acid] results in increased expression of NQO1 mRNA CTD PMID:33749747 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Uric Acid] results in increased expression of NR0B2 mRNA CTD PMID:33749747 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase decreases expression
multiple interactions		 ISO Uric Acid results in decreased expression of OGG1 mRNA
NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of OGG1 mRNA]		 CTD PMID:23619996 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Uric Acid inhibits the reaction [sodium arsenite inhibits the reaction [PARP1 protein binds to Zinc]]; Uric Acid inhibits the reaction [sodium arsenite results in decreased activity of and results in increased nitrosation of PARP1 protein] CTD PMID:31152818 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pawr pro-apoptotic WT1 regulator multiple interactions EXP Uric Acid inhibits the reaction [Nerve Growth Factors deficiency results in increased expression of PAWR mRNA]; Uric Acid inhibits the reaction [Nerve Growth Factors deficiency results in increased expression of PAWR protein] CTD PMID:10428045 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028 		JBrowse link
G Pml PML nuclear body scaffold multiple interactions ISO PML protein promotes the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased expression of IL1B protein]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of IL1B protein]; Uric Acid promotes the reaction [Lipopolysaccharides results in increased expression of PML protein] CTD PMID:23430110 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Polb DNA polymerase beta multiple interactions
decreases expression		 ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of POLB mRNA] CTD PMID:23619996 NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812 		JBrowse link
G Pon1 paraoxonase 1 affects abundance ISO PON1 protein polymorphism affects the abundance of Uric Acid CTD PMID:23747713 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Uric Acid] results in decreased expression of PPARA protein CTD PMID:33749747 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Prdx1 peroxiredoxin 1 increases expression ISO Uric Acid results in increased expression of PRDX1 protein CTD PMID:23619996 NCBI chr 5:130,147,276...130,162,850
Ensembl chr 5:130,147,204...130,162,856 		JBrowse link
G Prim1 DNA primase subunit 1 multiple interactions
decreases expression		 ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of PRIM1 mRNA] CTD PMID:23619996 NCBI chr 7:446,342...462,526
Ensembl chr 7:431,805...462,526 		JBrowse link
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 affects abundance ISO PRKAG2 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr 4:10,010,574...10,252,152
Ensembl chr 4:10,010,890...10,252,142 		JBrowse link
G Prkg2 protein kinase cGMP-dependent 2 decreases expression ISO Uric Acid results in decreased expression of PRKG2 mRNA CTD PMID:27542954 NCBI chr14:10,559,882...10,668,479
Ensembl chr14:10,559,882...10,666,888 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta multiple interactions
increases phosphorylation		 ISO Apigenin inhibits the reaction [Uric Acid results in increased phosphorylation of PTK2B protein] CTD PMID:29960001 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of CASP1 protein]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of and results in increased cleavage of IL1B protein]; PYCARD protein affects the reaction [Uric Acid results in increased cleavage of CASP1 protein]; PYCARD protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]
Apigenin inhibits the reaction [Uric Acid promotes the reaction [PYCARD protein binds to PYCARD protein]]; kaempferol inhibits the reaction [Uric Acid promotes the reaction [PYCARD protein binds to PYCARD protein]]; PYCARD protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; Uric Acid promotes the reaction [PYCARD protein binds to PYCARD protein]		 CTD PMID:18403674 PMID:18604214 PMID:29960001 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Rad51 RAD51 recombinase multiple interactions
decreases expression		 ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of RAD51 mRNA] CTD PMID:23619996 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO		 Drugs, Chinese Herbal inhibits the reaction [Uric Acid results in increased localization of and results in increased activity of RELA protein]; Uric Acid results in increased localization of and results in increased activity of RELA protein
Uric Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased phosphorylation of RELA protein]		 CTD PMID:19655406 PMID:33749747 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rfc3 replication factor C subunit 3 multiple interactions
decreases expression		 ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of RFC3 mRNA] CTD PMID:23619996 NCBI chr12:1,000,987...1,011,778
Ensembl chr12:1,000,994...1,011,778 		JBrowse link
G Rfc4 replication factor C subunit 4 multiple interactions
decreases expression		 ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of RFC4 mRNA] CTD PMID:23619996 NCBI chr11:77,749,642...77,764,123
Ensembl chr11:77,749,638...77,764,122 		JBrowse link
G Sfmbt1 Scm-like with four mbt domains 1 affects abundance ISO SFMBT1 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr16:5,889,046...6,009,860
Ensembl chr16:5,890,782...6,006,605 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions ISO Uric Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA] CTD PMID:33749747 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slc12a2 solute carrier family 12 member 2 multiple interactions EXP Uric Acid inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; Uric Acid inhibits the reaction [Manganese results in increased phosphorylation of and results in increased activity of SLC12A2 protein] CTD PMID:25817889 NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440 		JBrowse link
G Slc17a3 solute carrier family 17 member 3 affects transport ISO SLC17A3 gene SNP affects the transport of Uric Acid CTD PMID:21282933 NCBI chr17:41,270,804...41,300,132
Ensembl chr17:41,270,812...41,295,256 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 increases import
increases uptake
affects transport
multiple interactions
increases export		 ISO
EXP		 SLC22A12 protein results in increased import of Uric Acid
SLC22A12 protein results in increased uptake of Uric Acid
SLC22A12 protein affects the transport of Uric Acid
Benzbromarone inhibits the reaction [SLC22A12 protein affects the transport of Uric Acid]; Chlorides affects the reaction [SLC22A12 protein affects the transport of Uric Acid]; Lactic Acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid]; pyrazinoic acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid]
SLC22A12 protein results in increased export of Uric Acid
Benzbromarone inhibits the reaction [SLC22A12 protein affects the transport of Uric Acid]; gluconic acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid]; Lactic Acid affects the reaction [SLC22A12 protein affects the transport of Uric Acid]; Probenecid inhibits the reaction [SLC22A12 protein affects the transport of Uric Acid]; pyrazinoic acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid]
6-hydroxybenzbromarone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; [Chlorine co-treated with perfluoro-n-heptanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]; [Chlorine co-treated with perfluoro-n-nonanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]; [Chlorine co-treated with perfluorodecanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]; [Chlorine co-treated with perfluorooctanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]; [Losartan results in decreased activity of SLC22A12 protein] which results in decreased abundance of Uric Acid; benzarone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Benzbromarone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Chlorine inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]; E 3040 inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Enalapril inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Indomethacin inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Phenylbutazone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Probenecid inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Salicylates inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Sulfinpyrazone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Uric Acid inhibits the reaction [SLC22A12 protein results in increased uptake of Oxypurinol]		 CTD PMID:14694169 PMID:14747372 PMID:15284287 PMID:16135657 PMID:18670416 More... NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555 		JBrowse link
G Slc22a20 solute carrier family 22 member 20 multiple interactions ISO Uric Acid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate] CTD PMID:16478971 NCBI chr 1:203,257,374...203,273,848
Ensembl chr 1:203,257,374...203,273,822 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions
affects secretion
increases uptake		 ISO
EXP		 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]; Benzbromarone inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]; gluconic acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]; Glutarates promotes the reaction [SLC22A6 protein results in increased uptake of Uric Acid]; Ketoglutaric Acids inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]; p-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased uptake of Uric Acid]; Probenecid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]; pyrazinoic acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]; Salicylates inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]
SLC22A6 protein affects the secretion of Uric Acid
[Oxonic Acid co-treated with Uric Acid] results in decreased expression of SLC22A6 protein		 CTD PMID:12472777 PMID:19605544 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 affects transport
multiple interactions		 ISO
EXP		 SLC22A8 protein affects the transport of Uric Acid
[Oxonic Acid co-treated with Uric Acid] results in decreased expression of SLC22A8 protein		 CTD PMID:11306713 PMID:19605544 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Slc2a9 solute carrier family 2 member 9 multiple interactions
affects abundance
affects transport
increases transport
decreases secretion		 ISO Benzbromarone inhibits the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid]; Fructose promotes the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid]; Glucose promotes the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid]
SLC2A9 gene polymorphism affects the abundance of Uric Acid; SLC2A9 intron SNP affects the abundance of Uric Acid
SLC2A9 protein affects the transport of Uric Acid
Benzbromarone inhibits the reaction [SLC2A9 protein results in increased uptake of Uric Acid]; Losartan inhibits the reaction [SLC2A9 protein results in increased uptake of Uric Acid]; Phloretin inhibits the reaction [SLC2A9 protein results in increased uptake of Uric Acid]
SLC2A9 protein alternative form affects the transport of Uric Acid
SLC2A9 protein results in decreased secretion of Uric Acid		 CTD PMID:18327256 PMID:18327257 PMID:18842065 PMID:19587147 PMID:22132990 NCBI chr14:72,328,334...72,461,981
Ensembl chr14:72,328,320...72,461,981 		JBrowse link
G Slc51b solute carrier family 51 subunit beta multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Uric Acid] results in increased expression of SLC51B mRNA CTD PMID:33749747 NCBI chr 8:65,931,891...65,934,893
Ensembl chr 8:65,931,890...65,940,145 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Uric Acid] results in decreased expression of SLCO1B2 mRNA CTD PMID:33749747 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Sod1 superoxide dismutase 1 affects activity ISO Uric Acid affects the activity of SOD1 protein CTD PMID:10949969 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Uric Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of SOD2 protein] CTD PMID:21767162 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sord sorbitol dehydrogenase increases expression ISO Uric Acid results in increased expression of SORD protein CTD PMID:30651350 NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133 		JBrowse link
G Stc1 stanniocalcin 1 affects abundance ISO STC1 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr15:44,299,591...44,311,695
Ensembl chr15:44,299,621...44,310,264 		JBrowse link
G Syk spleen associated tyrosine kinase multiple interactions
increases phosphorylation		 ISO Apigenin inhibits the reaction [Uric Acid results in increased phosphorylation of SYK protein]; N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine inhibits the reaction [Uric Acid results in increased phosphorylation of SYK protein] CTD PMID:29960001 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases secretion
multiple interactions
increases expression		 ISO Uric Acid results in increased secretion of TGFB1 protein
ALPK1 protein promotes the reaction [Uric Acid results in increased secretion of TGFB1 protein]
Uric Acid results in increased expression of TGFB1 mRNA		 CTD PMID:27542954 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tmem171 transmembrane protein 171 affects abundance ISO TMEM171 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr 2:30,035,278...30,045,996
Ensembl chr 2:30,035,278...30,045,049 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 EXP
ISO		 Drugs, Chinese Herbal inhibits the reaction [Uric Acid results in increased expression of TNF mRNA]; Drugs, Chinese Herbal inhibits the reaction [Uric Acid results in increased expression of TNF protein]
Uric Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF mRNA]; Uric Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF protein]
Uric Acid results in increased expression of TNF mRNA; Uric Acid results in increased expression of TNF protein		 CTD PMID:19655406 PMID:33749747 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases phosphorylation ISO Uric Acid results in increased phosphorylation of TRP53 protein CTD PMID:23619996 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trim46 tripartite motif-containing 46 affects abundance ISO TRIM46 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr 2:174,641,494...174,654,237
Ensembl chr 2:174,641,496...174,654,141 		JBrowse link
G Ttk Ttk protein kinase multiple interactions
decreases expression		 ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of TTK mRNA] CTD PMID:23619996 NCBI chr 8:84,754,329...84,792,653
Ensembl chr 8:84,754,315...84,792,651 		JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO TXN protein affects the reaction [Uric Acid results in increased secretion of IL1B protein] CTD PMID:18403674 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
G Tyms thymidylate synthetase multiple interactions
decreases expression		 ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of TYMS mRNA] CTD PMID:23619996 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536 		JBrowse link
G Ube2q2 ubiquitin conjugating enzyme E2 Q2 affects abundance ISO UBE2Q2 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr 8:55,518,402...55,578,342
Ensembl chr 8:55,519,147...55,577,212 		JBrowse link
G Vegfa vascular endothelial growth factor A affects abundance ISO VEGFA gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions
increases chemical synthesis
increases abundance		 ISO
EXP		 Fructose promotes the reaction [XDH protein results in increased chemical synthesis of Uric Acid]
[1-Naphthylisothiocyanate co-treated with Uric Acid] results in increased expression of XDH mRNA; [bisphenol A results in increased activity of XDH protein] which results in increased chemical synthesis of Uric Acid; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [XDH protein results in increased chemical synthesis of Uric Acid]]; Tetradecanoylphorbol Acetate promotes the reaction [XDH protein results in increased chemical synthesis of Uric Acid]
[2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased activity of XDH protein] which results in decreased abundance of Uric Acid
XDH protein results in increased abundance of Uric Acid		 CTD PMID:17439425 PMID:19158351 PMID:21920950 PMID:22036979 PMID:31574244 More... NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 multiple interactions
decreases expression		 ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of XRCC1 mRNA] CTD PMID:23619996 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        biochemical role 19381
          metabolite 19356
            eukaryotic metabolite 19044
              animal metabolite 18887
                mammalian metabolite 18886
                  human metabolite 18346
                    uric acid 109
                      1H-purine-2,6,8-triol 0
                      2,6-dihydroxy-7,9-dihydro-8H-purin-8-one 0
                      5,7-dihydro-1H-purine-2,6,8(9H)-trione + 0
                      6-hydroxy-1H-purine-2,8(7H,9H)-dione 0
                      7,9-dihydro-1H-purine-2,6,8(3H)-trione + 109
                      7H-purine-2,6,8-triol 0
                      9H-purine-2,6,8-triol 0
                      urate salt 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic molecule 19560
                              organic cyclic compound 19351
                                organic heterocyclic compound 18582
                                  organic heteropolycyclic compound 18059
                                    organic heterobicyclic compound 16869
                                      imidazopyrimidine 5611
                                        purines 5609
                                          oxopurine 4067
                                            uric acid 109
                                              1H-purine-2,6,8-triol 0
                                              2,6-dihydroxy-7,9-dihydro-8H-purin-8-one 0
                                              5,7-dihydro-1H-purine-2,6,8(9H)-trione + 0
                                              6-hydroxy-1H-purine-2,8(7H,9H)-dione 0
                                              7,9-dihydro-1H-purine-2,6,8(3H)-trione + 109
                                              7H-purine-2,6,8-triol 0
                                              9H-purine-2,6,8-triol 0
                                              urate salt 0
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