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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:uric acid
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Accession:CHEBI:27226 term browser browse the term
Definition:An oxopurine that is the final oxidation product of purine metabolism.
Synonyms:related_synonym: Formula=C5H4N4O3;   uric acids
 xref: HMDB:HMDB0000289;   Wikipedia:Uric_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:30848;   is_conjugate_acid_of CHEBI:46818

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1-methyluric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Xdh xanthine dehydrogenase multiple interactions ISO [XDH protein alternative form results in increased metabolism of 1-methylxanthine] which results in increased chemical synthesis of 1-methyluric acid CTD PMID:19215233 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494 		JBrowse link
7,9-dihydro-1H-purine-2,6,8(3H)-trione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A1cf APOBEC1 complementation factor affects abundance ISO A1CF gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr 1:250,426,027...250,514,245
Ensembl chr 1:250,426,158...250,514,866 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 affects export
multiple interactions		 ISO ABCC4 protein affects the export of Uric Acid
Uric Acid inhibits the reaction [ABCC4 protein affects the transport of Methotrexate]		 CTD PMID:15454390 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592 		JBrowse link
G Ace angiotensin I converting enzyme multiple interactions
increases expression		 ISO APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of ACE mRNA] CTD PMID:30710622 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822 		JBrowse link
G Agt angiotensinogen multiple interactions
increases expression		 ISO resveratrol inhibits the reaction [Uric Acid results in increased expression of AGT mRNA]; resveratrol inhibits the reaction [Uric Acid results in increased expression of AGT protein]
Uric Acid results in increased expression of AGT mRNA; Uric Acid results in increased expression of AGT protein modified form
APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGT mRNA]; APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGT protein modified form]		 CTD PMID:25493383 PMID:30710622 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions
increases expression		 ISO APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGTR1A mRNA] CTD PMID:30710622 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 increases expression
multiple interactions		 ISO Uric Acid results in increased expression of AGTR2 mRNA
APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGTR2 mRNA]		 CTD PMID:30710622 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases expression
multiple interactions		 ISO Uric Acid results in increased expression of AKR1B3 mRNA
acetovanillone inhibits the reaction [Uric Acid results in increased expression of AKR1B3 mRNA]		 CTD PMID:30651350 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956 		JBrowse link
G Alad aminolevulinate dehydratase multiple interactions ISO Uric Acid affects the reaction [ALAD polymorphism affects the susceptibility to Lead] CTD PMID:16263504 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346 		JBrowse link
G Aldh16a1 aldehyde dehydrogenase 16 family, member A1 affects abundance ISO ALDH16A1 gene SNP affects the abundance of Uric Acid CTD PMID:21983786 NCBI chr 1:101,138,237...101,151,320
Ensembl chr 1:101,138,248...101,151,320 		JBrowse link
G Alpk1 alpha-kinase 1 increases expression
multiple interactions
increases response to substance		 ISO Uric Acid results in increased expression of ALPK1 mRNA
ALPK1 protein promotes the reaction [Uric Acid results in increased secretion of TGFB1 protein]
ALPK1 protein results in increased susceptibility to Uric Acid		 CTD PMID:27542954 NCBI chr 2:231,997,360...232,117,471
Ensembl chr 2:231,996,088...232,117,134 		JBrowse link
G Apln apelin multiple interactions ISO APLN protein modified form inhibits the reaction [Uric Acid results in decreased activity of CAT protein]; APLN protein modified form inhibits the reaction [Uric Acid results in decreased expression of APLNR mRNA]; APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of ACE mRNA]; APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGT mRNA]; APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGT protein modified form]; APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGTR1A mRNA]; APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGTR2 mRNA] CTD PMID:30710622 NCBI chr  X:134,856,719...134,866,210
Ensembl chr  X:134,856,726...134,866,210 		JBrowse link
G Aplnr apelin receptor multiple interactions
decreases expression		 ISO APLN protein modified form inhibits the reaction [Uric Acid results in decreased expression of APLNR mRNA] CTD PMID:30710622 NCBI chr 3:72,540,538...72,544,183
Ensembl chr 3:72,540,538...72,544,182 		JBrowse link
G Aqp1 aquaporin 1 multiple interactions ISO AQP1 mRNA affects the reaction [Uric Acid results in increased secretion of IL1B protein] CTD PMID:21051542 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360 		JBrowse link
G Aqp9 aquaporin 9 multiple interactions ISO AQP9 mRNA affects the reaction [Uric Acid results in increased secretion of IL1B protein] CTD PMID:21051542 NCBI chr 8:77,559,621...77,599,781
Ensembl chr 8:77,559,624...77,599,781 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO Uric Acid inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 mRNA] CTD PMID:21703327 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772 		JBrowse link
G Atr ATR serine/threonine kinase multiple interactions
increases phosphorylation		 ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of ATR protein] CTD PMID:23619996 NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947 		JBrowse link
G Atxn2 ataxin 2 affects abundance ISO ATXN2 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr12:40,264,601...40,335,637
Ensembl chr12:40,266,662...40,332,612 		JBrowse link
G B3gnt4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 affects abundance ISO B3GNT4 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr12:38,503,361...38,506,793
Ensembl chr12:38,503,361...38,504,774 		JBrowse link
G Baz1b bromodomain adjacent to zinc finger domain, 1B affects abundance ISO BAZ1B gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr12:24,478,882...24,536,851
Ensembl chr12:24,478,898...24,537,313 		JBrowse link
G Brca1 BRCA1, DNA repair associated multiple interactions
decreases expression		 ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of BRCA1 mRNA] CTD PMID:23619996 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681 		JBrowse link
G Casp1 caspase 1 multiple interactions
increases phosphorylation
increases expression
increases cleavage		 ISO [Lipopolysaccharides co-treated with Uric Acid] results in increased activity of CASP1 protein; [Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of CASP1 protein; CASP1 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of H2AX protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [Uric Acid results in increased cleavage of CASP1 protein]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of CASP1 protein]; PYCARD protein affects the reaction [Uric Acid results in increased cleavage of CASP1 protein]; Silicon Dioxide analog inhibits the reaction [Uric Acid results in increased cleavage of CASP1 protein]
Uric Acid results in increased phosphorylation of CASP1 protein
Uric Acid results in increased expression of CASP1 protein modified form
[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of CASP1 protein; Apigenin inhibits the reaction [Uric Acid results in increased expression of and results in increased cleavage of and results in increased secretion of CASP1 protein modified form]; CASP1 protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; NLRP3 protein affects the reaction [Uric Acid results in increased cleavage of CASP1 protein]		 CTD PMID:18403674 PMID:18604214 PMID:23430110 PMID:23619996 PMID:29960001 PMID:30842373 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631 		JBrowse link
G Cat catalase increases expression
multiple interactions
decreases activity		 ISO Uric Acid results in increased expression of CAT protein
APLN protein modified form inhibits the reaction [Uric Acid results in decreased activity of CAT protein]		 CTD PMID:23619996 PMID:30710622 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
increases secretion		 ISO
EXP		 [Fructose co-treated with Uric Acid] results in increased secretion of CCL2 protein; Allopurinol inhibits the reaction [[Fructose co-treated with Uric Acid] results in increased secretion of CCL2 protein]
Probenecid inhibits the reaction [Uric Acid results in increased expression of CCL2 protein]
Uric Acid results in increased secretion of CCL2 protein		 CTD PMID:16113518 PMID:19158351 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccnb1 cyclin B1 decreases expression
multiple interactions		 ISO Uric Acid results in decreased expression of CCNB1 mRNA
NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of CCNB1 mRNA]		 CTD PMID:23619996 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression		 ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of CCND1 mRNA] CTD PMID:23619996 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uric Acid; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uric Acid]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uric Acid] CTD PMID:24709313 NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997 		JBrowse link
G Cp ceruloplasmin affects activity ISO Uric Acid affects the activity of CP protein CTD PMID:10949969 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853 		JBrowse link
G Ctsb cathepsin B multiple interactions ISO [Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of CTSB protein CTD PMID:18604214 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612 		JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions ISO CYBA protein affects the reaction [Uric Acid results in increased secretion of IL1B protein] CTD PMID:18403674 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Uric Acid inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of DDIT3 mRNA] CTD PMID:21703327 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Edn1 endothelin 1 multiple interactions
increases expression		 ISO resveratrol inhibits the reaction [Uric Acid results in increased expression of EDN1 mRNA]; resveratrol inhibits the reaction [Uric Acid results in increased expression of EDN1 protein]
Uric Acid results in increased expression of EDN1 mRNA; Uric Acid results in increased expression of EDN1 protein		 CTD PMID:25493383 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324 		JBrowse link
G Gnai2 G protein subunit alpha i2 multiple interactions EXP Uric Acid inhibits the reaction [Glucose results in decreased expression of GNAI2 protein]; Uric Acid inhibits the reaction [Peroxynitrous Acid results in decreased expression of GNAI2 protein]; Uric Acid inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI2 protein] CTD PMID:16962941 PMID:18055527 PMID:18441196 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307 		JBrowse link
G Gnai3 G protein subunit alpha i3 multiple interactions EXP Uric Acid inhibits the reaction [Glucose results in decreased expression of GNAI3 protein]; Uric Acid inhibits the reaction [Peroxynitrous Acid results in decreased expression of GNAI3 protein]; Uric Acid inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI3 protein] CTD PMID:16962941 PMID:18055527 PMID:18441196 NCBI chr 2:210,896,779...210,934,733
Ensembl chr 2:210,896,656...210,934,749 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 affects abundance ISO GSTT1 protein polymorphism affects the abundance of Uric Acid CTD PMID:23747713 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526 		JBrowse link
G H2ax H2A.X variant histone increases phosphorylation
multiple interactions		 ISO Uric Acid results in increased phosphorylation of H2AX protein
CASP1 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of H2AX protein]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of H2AX protein]		 CTD PMID:23619996 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981 		JBrowse link
G Hlf HLF transcription factor, PAR bZIP family member affects abundance ISO HLF gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr10:77,836,352...77,918,656
Ensembl chr10:77,840,568...77,918,191 		JBrowse link
G Hnf4g hepatocyte nuclear factor 4, gamma affects abundance ISO HNF4G gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr 2:100,225,880...100,372,710
Ensembl chr 2:100,225,888...100,372,252 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor affects abundance ISO IGF1R gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
increases secretion		 EXP
ISO		 Drugs, Chinese Herbal inhibits the reaction [Uric Acid results in increased expression of IL1B mRNA]; Drugs, Chinese Herbal inhibits the reaction [Uric Acid results in increased expression of IL1B protein]
Uric Acid results in increased expression of IL1B mRNA; Uric Acid results in increased expression of IL1B protein
Uric Acid results in increased secretion of IL1B protein
[Lipopolysaccharides co-treated with Uric Acid] results in increased expression of and results in increased activity of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of and results in increased cleavage of IL1B protein; [Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of IL1B protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Chloroquine inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; CYBA protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of and results in increased secretion of IL1B protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of and results in increased cleavage of IL1B protein]; NLRP3 protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased expression of IL1B protein]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of IL1B protein]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of and results in increased cleavage of IL1B protein]; PYCARD protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; TXN protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; UOX protein inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of IL1B protein]
[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Uric Acid] results in increased expression of IL1B protein; Acetylcysteine inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Ammonium Chloride inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Apigenin inhibits the reaction [Uric Acid results in increased expression of and results in increased cleavage of and results in increased secretion of IL1B protein]; AQP1 mRNA affects the reaction [Uric Acid results in increased secretion of IL1B protein]; AQP9 mRNA affects the reaction [Uric Acid results in increased secretion of IL1B protein]; CASP1 protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; Chloroquine inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of and results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; diphenyleneiodonium inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; flavone analog inhibits the reaction [Uric Acid results in increased cleavage of and results in increased secretion of IL1B protein]; latrunculin A inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Mercuric Chloride inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine inhibits the reaction [Uric Acid results in increased cleavage of and results in increased secretion of IL1B protein]; NLRP3 protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; Phloretin inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; PYCARD protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone analog inhibits the reaction [Uric Acid results in increased cleavage of and results in increased secretion of IL1B protein]; Uric Acid results in increased expression of and results in increased cleavage of and results in increased secretion of IL1B protein		 CTD PMID:18403674 PMID:18604214 PMID:19655406 PMID:21051542 PMID:23430110 PMID:24158569 PMID:26296894 PMID:27542954 PMID:29960001 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Inhbb inhibin subunit beta B affects abundance ISO INHBB gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr13:35,436,532...35,442,222
Ensembl chr13:35,436,532...35,442,222 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 multiple interactions ISO Uric Acid inhibits the reaction [Ethanol results in increased expression of and affects the localization of ITPR1 protein] CTD PMID:17241155 NCBI chr 4:140,247,297...140,580,749
Ensembl chr 4:140,247,313...140,580,748 		JBrowse link
G Khk ketohexokinase increases expression EXP
ISO		 Uric Acid results in increased expression of KHK protein CTD PMID:30651350 NCBI chr 6:26,810,577...26,821,013
Ensembl chr 6:26,810,579...26,820,959 		JBrowse link
G Maf MAF bZIP transcription factor affects abundance ISO MAF gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr19:48,179,826...48,200,995
Ensembl chr19:48,194,804...48,196,748 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Uric Acid inhibits the reaction [Ammonium Chloride results in increased phosphorylation of MAPK1 protein] CTD PMID:11923223 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Uric Acid inhibits the reaction [Ammonium Chloride results in increased phosphorylation of MAPK3 protein] CTD PMID:11923223 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 affects abundance
affects localization		 ISO NFAT5 gene SNP affects the abundance of Uric Acid
Uric Acid affects the localization of NFAT5 protein		 CTD PMID:23263486 PMID:30651350 NCBI chr19:38,446,059...38,533,735
Ensembl chr19:38,446,059...38,533,735 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions
decreases response to substance		 ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of BRCA1 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of CCNB1 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of CCND1 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of OGG1 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of POLB mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of PRIM1 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of RAD51 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of RFC3 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of RFC4 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of TTK mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of TYMS mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of XRCC1 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of ATR protein]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of H2AX protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of and results in increased cleavage of IL1B protein]; NLRP3 protein affects the reaction [Uric Acid results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]
[Uric Acid co-treated with Lipopolysaccharides] results in increased activity of NLRP3 protein; NLRP3 protein affects the reaction [Uric Acid results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]
NLRP3 gene mutant form results in decreased susceptibility to Uric Acid		 CTD PMID:18403674 PMID:18604214 PMID:23619996 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254 		JBrowse link
G Nos3 nitric oxide synthase 3 increases abundance ISO NOS3 gene mutant form results in increased abundance of Uric Acid CTD PMID:12947532 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase decreases expression
multiple interactions		 ISO Uric Acid results in decreased expression of OGG1 mRNA
NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of OGG1 mRNA]		 CTD PMID:23619996 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326 		JBrowse link
G Pawr pro-apoptotic WT1 regulator multiple interactions EXP Uric Acid inhibits the reaction [Nerve Growth Factors deficiency results in increased expression of PAWR mRNA]; Uric Acid inhibits the reaction [Nerve Growth Factors deficiency results in increased expression of PAWR protein] CTD PMID:10428045 NCBI chr 7:51,273,764...51,353,700
Ensembl chr 7:51,273,771...51,353,068 		JBrowse link
G Pml PML nuclear body scaffold multiple interactions ISO PML protein promotes the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased expression of IL1B protein]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of IL1B protein]; Uric Acid promotes the reaction [Lipopolysaccharides results in increased expression of PML protein] CTD PMID:23430110 NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226 		JBrowse link
G Polb DNA polymerase beta multiple interactions
decreases expression		 ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of POLB mRNA] CTD PMID:23619996 NCBI chr16:74,237,001...74,260,272
Ensembl chr16:74,237,001...74,260,271 		JBrowse link
G Pon1 paraoxonase 1 affects abundance ISO PON1 protein polymorphism affects the abundance of Uric Acid CTD PMID:23747713 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372 		JBrowse link
G Prdx1 peroxiredoxin 1 increases expression ISO Uric Acid results in increased expression of PRDX1 protein CTD PMID:23619996 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990 		JBrowse link
G Prim1 DNA primase subunit 1 multiple interactions
decreases expression		 ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of PRIM1 mRNA] CTD PMID:23619996 NCBI chr 7:2,435,524...2,451,169
Ensembl chr 7:2,435,553...2,451,165 		JBrowse link
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 affects abundance ISO PRKAG2 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr 4:6,559,153...6,799,888
Ensembl chr 4:6,559,545...6,799,632 		JBrowse link
G Prkg2 protein kinase cGMP-dependent 2 decreases expression ISO Uric Acid results in decreased expression of PRKG2 mRNA CTD PMID:27542954 NCBI chr14:12,217,121...12,313,616
Ensembl chr14:12,218,553...12,315,229 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta multiple interactions
increases phosphorylation		 ISO Apigenin inhibits the reaction [Uric Acid results in increased phosphorylation of PTK2B protein] CTD PMID:29960001 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of CASP1 protein]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of and results in increased cleavage of IL1B protein]; PYCARD protein affects the reaction [Uric Acid results in increased cleavage of CASP1 protein]; PYCARD protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]
Apigenin inhibits the reaction [Uric Acid promotes the reaction [PYCARD protein binds to PYCARD protein]]; kaempferol inhibits the reaction [Uric Acid promotes the reaction [PYCARD protein binds to PYCARD protein]]; PYCARD protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; Uric Acid promotes the reaction [PYCARD protein binds to PYCARD protein]		 CTD PMID:18403674 PMID:18604214 PMID:29960001 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210 		JBrowse link
G Rad51 RAD51 recombinase multiple interactions
decreases expression		 ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of RAD51 mRNA] CTD PMID:23619996 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Drugs, Chinese Herbal inhibits the reaction [Uric Acid results in increased localization of and results in increased activity of RELA protein]; Uric Acid results in increased localization of and results in increased activity of RELA protein CTD PMID:19655406 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Rfc3 replication factor C subunit 3 multiple interactions
decreases expression		 ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of RFC3 mRNA] CTD PMID:23619996 NCBI chr12:1,460,581...1,471,344
Ensembl chr12:1,460,538...1,471,357 		JBrowse link
G Rfc4 replication factor C subunit 4 multiple interactions
decreases expression		 ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of RFC4 mRNA] CTD PMID:23619996 NCBI chr11:81,358,592...81,373,044
Ensembl chr11:81,358,592...81,373,043 		JBrowse link
G Sfmbt1 Scm-like with four mbt domains 1 affects abundance ISO SFMBT1 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr16:6,775,648...6,896,155
Ensembl chr16:6,779,281...6,895,299 		JBrowse link
G Slc12a2 solute carrier family 12 member 2 multiple interactions EXP Uric Acid inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; Uric Acid inhibits the reaction [Manganese results in increased phosphorylation of and results in increased activity of SLC12A2 protein] CTD PMID:25817889 NCBI chr18:52,917,124...52,985,281
Ensembl chr18:52,917,124...52,985,261 		JBrowse link
G Slc17a3 solute carrier family 17 member 3 affects transport ISO SLC17A3 gene SNP affects the transport of Uric Acid CTD PMID:21282933 NCBI chr17:43,518,760...43,545,160
Ensembl chr17:43,518,655...43,543,185 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 increases import
increases uptake
affects transport
multiple interactions
increases export		 ISO
EXP		 SLC22A12 protein results in increased import of Uric Acid
SLC22A12 protein results in increased uptake of Uric Acid
SLC22A12 protein affects the transport of Uric Acid
Benzbromarone inhibits the reaction [SLC22A12 protein affects the transport of Uric Acid]; Chlorides affects the reaction [SLC22A12 protein affects the transport of Uric Acid]; Lactic Acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid]; pyrazinoic acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid]
SLC22A12 protein results in increased export of Uric Acid
Benzbromarone inhibits the reaction [SLC22A12 protein affects the transport of Uric Acid]; gluconic acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid]; Lactic Acid affects the reaction [SLC22A12 protein affects the transport of Uric Acid]; Probenecid inhibits the reaction [SLC22A12 protein affects the transport of Uric Acid]; pyrazinoic acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid]
6-hydroxybenzbromarone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; [Chlorine co-treated with perfluoro-n-heptanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]; [Chlorine co-treated with perfluoro-n-nonanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]; [Chlorine co-treated with perfluorodecanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]; [Chlorine co-treated with perfluorooctanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]; [Losartan results in decreased activity of SLC22A12 protein] which results in decreased abundance of Uric Acid; benzarone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Benzbromarone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Chlorine inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]; E 3040 inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Enalapril inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Indomethacin inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Phenylbutazone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Probenecid inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Salicylates inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Sulfinpyrazone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Uric Acid inhibits the reaction [SLC22A12 protein results in increased uptake of Oxypurinol]		 CTD PMID:14694169 PMID:14747372 PMID:15284287 PMID:16135657 PMID:18670416 PMID:20639259 PMID:21074513 PMID:21272127 PMID:21449597 NCBI chr 1:221,910,787...221,919,277
Ensembl chr 1:221,910,767...221,919,301 		JBrowse link
G Slc22a20 solute carrier family 22 member 20 multiple interactions ISO Uric Acid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate] CTD PMID:16478971 NCBI chr 1:221,327,608...221,344,367
Ensembl chr 1:221,328,711...221,343,889 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions
affects secretion
increases uptake		 ISO
EXP		 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]; Benzbromarone inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]; gluconic acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]; Glutarates promotes the reaction [SLC22A6 protein results in increased uptake of Uric Acid]; Ketoglutaric Acids inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]; p-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased uptake of Uric Acid]; Probenecid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]; pyrazinoic acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]; Salicylates inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]
SLC22A6 protein affects the secretion of Uric Acid
[Oxonic Acid co-treated with Uric Acid] results in decreased expression of SLC22A6 protein		 CTD PMID:12472777 PMID:19605544 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 affects transport
multiple interactions		 ISO
EXP		 SLC22A8 protein affects the transport of Uric Acid
[Oxonic Acid co-treated with Uric Acid] results in decreased expression of SLC22A8 protein		 CTD PMID:11306713 PMID:19605544 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482 		JBrowse link
G Slc2a9 solute carrier family 2 member 9 multiple interactions
affects abundance
affects transport
increases transport
decreases secretion		 ISO Benzbromarone inhibits the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid]; Fructose promotes the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid]; Glucose promotes the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid]
SLC2A9 gene polymorphism affects the abundance of Uric Acid; SLC2A9 intron SNP affects the abundance of Uric Acid
SLC2A9 protein affects the transport of Uric Acid
Benzbromarone inhibits the reaction [SLC2A9 protein results in increased uptake of Uric Acid]; Losartan inhibits the reaction [SLC2A9 protein results in increased uptake of Uric Acid]; Phloretin inhibits the reaction [SLC2A9 protein results in increased uptake of Uric Acid]
SLC2A9 protein alternative form affects the transport of Uric Acid
SLC2A9 protein results in decreased secretion of Uric Acid		 CTD PMID:18327256 PMID:18327257 PMID:18842065 PMID:19587147 PMID:22132990 NCBI chr14:77,067,537...77,192,702
Ensembl chr14:77,067,503...77,192,702 		JBrowse link
G Sod1 superoxide dismutase 1 affects activity ISO Uric Acid affects the activity of SOD1 protein CTD PMID:10949969 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Uric Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of SOD2 protein] CTD PMID:21767162 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Sord sorbitol dehydrogenase increases expression ISO Uric Acid results in increased expression of SORD protein CTD PMID:30651350 NCBI chr 3:114,176,127...114,207,368
Ensembl chr 3:114,176,309...114,207,366 		JBrowse link
G Stc1 stanniocalcin 1 affects abundance ISO STC1 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr15:50,891,137...50,901,791
Ensembl chr15:50,891,127...50,903,162 		JBrowse link
G Syk spleen associated tyrosine kinase multiple interactions
increases phosphorylation		 ISO Apigenin inhibits the reaction [Uric Acid results in increased phosphorylation of SYK protein]; N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine inhibits the reaction [Uric Acid results in increased phosphorylation of SYK protein] CTD PMID:29960001 NCBI chr17:12,614,311...12,669,568
Ensembl chr17:12,614,311...12,669,573 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases secretion
multiple interactions
increases expression		 ISO Uric Acid results in increased secretion of TGFB1 protein
ALPK1 protein promotes the reaction [Uric Acid results in increased secretion of TGFB1 protein]
Uric Acid results in increased expression of TGFB1 mRNA		 CTD PMID:27542954 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tmem171 transmembrane protein 171 affects abundance ISO TMEM171 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr 2:28,791,831...28,802,135
Ensembl chr 2:28,791,875...28,801,223 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 EXP Drugs, Chinese Herbal inhibits the reaction [Uric Acid results in increased expression of TNF mRNA]; Drugs, Chinese Herbal inhibits the reaction [Uric Acid results in increased expression of TNF protein]
Uric Acid results in increased expression of TNF mRNA; Uric Acid results in increased expression of TNF protein		 CTD PMID:19655406 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 increases phosphorylation ISO Uric Acid results in increased phosphorylation of TRP53 protein CTD PMID:23619996 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Trim46 tripartite motif-containing 46 affects abundance ISO TRIM46 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr 2:188,548,608...188,561,617
Ensembl chr 2:188,548,644...188,561,360 		JBrowse link
G Ttk Ttk protein kinase multiple interactions
decreases expression		 ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of TTK mRNA] CTD PMID:23619996 NCBI chr 8:91,368,065...91,405,995
Ensembl chr 8:91,368,111...91,405,993 		JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO TXN protein affects the reaction [Uric Acid results in increased secretion of IL1B protein] CTD PMID:18403674 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752 		JBrowse link
G Tyms thymidylate synthetase multiple interactions
decreases expression		 ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of TYMS mRNA] CTD PMID:23619996 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564 		JBrowse link
G Ube2q2 ubiquitin conjugating enzyme E2 Q2 affects abundance ISO UBE2Q2 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr 8:59,709,972...59,754,102
Ensembl chr 8:59,711,549...59,766,889 		JBrowse link
G Vegfa vascular endothelial growth factor A affects abundance ISO VEGFA gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions
increases chemical synthesis
increases abundance		 ISO
EXP		 Fructose promotes the reaction [XDH protein results in increased chemical synthesis of Uric Acid]
[bisphenol A results in increased activity of XDH protein] which results in increased chemical synthesis of Uric Acid; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [XDH protein results in increased chemical synthesis of Uric Acid]]; Tetradecanoylphorbol Acetate promotes the reaction [XDH protein results in increased chemical synthesis of Uric Acid]
[2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased activity of XDH protein] which results in decreased abundance of Uric Acid
XDH protein results in increased abundance of Uric Acid		 CTD PMID:17439425 PMID:19158351 PMID:21920950 PMID:22036979 PMID:31574244 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 multiple interactions
decreases expression		 ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of XRCC1 mRNA] CTD PMID:23619996 NCBI chr 1:81,412,635...81,441,680
Ensembl chr 1:81,413,353...81,441,678 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        biochemical role 19304
          metabolite 19285
            eukaryotic metabolite 18934
              animal metabolite 18741
                mammalian metabolite 18740
                  human metabolite 18251
                    uric acid 88
                      1H-purine-2,6,8-triol 0
                      2,6-dihydroxy-7,9-dihydro-8H-purin-8-one 0
                      5,7-dihydro-1H-purine-2,6,8(9H)-trione + 0
                      6-hydroxy-1H-purine-2,8(7H,9H)-dione 0
                      7,9-dihydro-1H-purine-2,6,8(3H)-trione + 88
                      7H-purine-2,6,8-triol 0
                      9H-purine-2,6,8-triol 0
                      urate salt 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic molecule 19514
                              organic cyclic compound 19311
                                organic heterocyclic compound 18425
                                  organic heteropolycyclic compound 17838
                                    organic heterobicyclic compound 16763
                                      imidazopyrimidine 5444
                                        purines 5442
                                          oxopurine 4027
                                            uric acid 88
                                              1H-purine-2,6,8-triol 0
                                              2,6-dihydroxy-7,9-dihydro-8H-purin-8-one 0
                                              5,7-dihydro-1H-purine-2,6,8(9H)-trione + 0
                                              6-hydroxy-1H-purine-2,8(7H,9H)-dione 0
                                              7,9-dihydro-1H-purine-2,6,8(3H)-trione + 88
                                              7H-purine-2,6,8-triol 0
                                              9H-purine-2,6,8-triol 0
                                              urate salt 0
paths to the root