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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Ile(5)-angiotensin II
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Accession:CHEBI:2719 term browser browse the term
Definition:An angiotensin II that acts on the central nervous system (PDB entry: 1N9V).
Synonyms:exact_synonym: L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanine
 related_synonym: 5-L-isoleucineangiotensin II;   5-isoleucine-angiotensin II;   Angiotensin;   Angiotonin;   Asp-Arg-Val-Tyr-Ile-His-Pro-Phe;   Formula=C50H71N13O12;   Hypertensin;   InChI=1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41-/m0/s1;   InChIKey=CZGUSIXMZVURDU-JZXHSEFVSA-N;   N-(1-(N-(N-(N-(N-(N(2)-L-alpha-aspartyl-L-arginyl)-L-valyl)-L-tyrosyl)-L-isoleucyl)-L-histidyl)-L-prolyl)-L-phenylalanine;   SMILES=CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O;   angiotensin II;   angiotensin II (mouse);   human angiotensin II
 alt_id: CHEBI:131170
 xref: CAS:11128-99-7;   CAS:4474-91-3;   HMDB:HMDB0001035;   KEGG:C02135;   LINCS:LSM-42772
 xref_mesh: MESH:D000804
 xref: PMID:16672146;   Reaxys:4289487
 cyclic_relationship: is_tautomer_of CHEBI:58506


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Ile(5)-angiotensin II term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 affects abundance ISO [ACE2 protein affects the abundance of Angiotensin I] which affects the abundance of Angiotensin II; ACE2 protein affects the abundance of Angiotensin II CTD PMID:27649628 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Agt angiotensinogen multiple interactions ISO [[Lisinopril co-treated with chymostatin] affects the metabolism of AGT protein] which results in decreased abundance of Angiotensin II; [Lisinopril affects the metabolism of AGT protein] which results in decreased abundance of Angiotensin II CTD PMID:27649628 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 increases expression EXP Angiotensin II results in increased expression of AGTR2 mRNA; Angiotensin II results in increased expression of AGTR2 protein CTD PMID:12969123 NCBI chr  X:116,914,320...116,918,504
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO naoxintong inhibits the reaction [Angiotensin II results in increased expression of BAX mRNA] CTD PMID:38230784 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions		 ISO Angiotensin II results in increased expression of CCL2 mRNA
naoxintong inhibits the reaction [Angiotensin II results in increased expression of CCL2 mRNA]		 CTD PMID:38230784 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression
multiple interactions		 ISO Angiotensin II results in increased expression of COL1A1 mRNA
NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of COL1A1 mRNA]		 CTD PMID:33746155 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression ISO Angiotensin II results in increased expression of COL3A1 mRNA CTD PMID:33746155 NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression
multiple interactions		 EXP Angiotensin II results in decreased expression of CPT1A mRNA
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of CPT1A mRNA]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of CPT1A mRNA]]		 CTD PMID:37269933 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Ednrb endothelin receptor type B increases expression EXP Angiotensin II results in increased expression of EDNRB protein CTD PMID:15007106 NCBI chr15:87,055,490...87,086,765
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions
decreases expression		 EXP celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of ESRRA protein]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of ESRRA protein]] CTD PMID:37269933 NCBI chr 1:213,533,309...213,543,432
Ensembl chr 1:204,104,101...204,114,268 		JBrowse link
G Fis1 fission, mitochondrial 1 increases expression
multiple interactions		 ISO Angiotensin II results in increased expression of FIS1 protein
naoxintong inhibits the reaction [Angiotensin II results in increased expression of FIS1 protein]		 CTD PMID:38230784 NCBI chr12:25,345,239...25,360,135
Ensembl chr12:19,708,558...19,723,377 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 ISO naoxintong inhibits the reaction [Angiotensin II results in increased expression of IL1B mRNA] CTD PMID:38230784 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO Angiotensin II results in increased expression of IL6 protein
naoxintong inhibits the reaction [Angiotensin II results in increased expression of IL6 protein]		 CTD PMID:38230784 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
decreases expression		 ISO naoxintong inhibits the reaction [Angiotensin II results in decreased expression of MCL1 protein] CTD PMID:38230784 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Myh6 myosin heavy chain 6 decreases expression
multiple interactions		 EXP Angiotensin II results in decreased expression of MYH6 mRNA
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of MYH6 mRNA alternative form]		 CTD PMID:37269933 NCBI chr15:32,388,102...32,413,663
Ensembl chr15:28,417,616...28,441,720 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of COL1A1 mRNA]; NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of NOX4 protein] CTD PMID:33746155 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nox4 NADPH oxidase 4 increases expression
multiple interactions		 ISO Angiotensin II results in increased expression of NOX4 protein
NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of NOX4 protein]
Angiotensin II results in increased expression of NOX4 mRNA
naoxintong inhibits the reaction [Angiotensin II results in increased expression of NOX4 mRNA]		 CTD PMID:33746155 PMID:38230784 NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Nppa natriuretic peptide A multiple interactions
increases expression		 EXP celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of NPPA mRNA] CTD PMID:37269933 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B multiple interactions
increases expression		 EXP celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of NPPB mRNA] CTD PMID:37269933 NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 affects response to substance ISO NR1I2 protein affects the susceptibility to Angiotensin II CTD PMID:33746155 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 decreases expression
multiple interactions		 EXP Angiotensin II results in decreased expression of PDHA1 mRNA
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PDHA1 mRNA]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PDHA1 mRNA]]		 CTD PMID:37269933 NCBI chr  X:38,509,158...38,522,986
Ensembl chr  X:34,700,409...34,714,311 		JBrowse link
G Pfkm phosphofructokinase, muscle multiple interactions
increases expression		 EXP celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of PFKM mRNA]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of PFKM mRNA]] CTD PMID:37269933 NCBI chr 7:131,100,684...131,138,250
Ensembl chr 7:129,221,653...129,259,192 		JBrowse link
G Postn periostin increases expression ISO Angiotensin II results in increased expression of POSTN mRNA; Angiotensin II results in increased expression of POSTN protein CTD PMID:33746155 NCBI chr 2:140,677,774...140,709,304
Ensembl chr 2:138,527,696...138,559,099 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of CPT1A mRNA]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of ESRRA protein]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PDHA1 mRNA]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of TFAM protein]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of PFKM mRNA]] CTD PMID:37269933 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression
multiple interactions		 EXP Angiotensin II results in decreased expression of PPARGC1A protein
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PPARGC1A protein]		 CTD PMID:37269933 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ppargc1b PPARG coactivator 1 beta multiple interactions
decreases expression		 EXP celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PPARGC1B protein] CTD PMID:37269933 NCBI chr18:57,029,264...57,131,466
Ensembl chr18:54,758,902...54,861,194 		JBrowse link
G Tfam transcription factor A, mitochondrial decreases expression
multiple interactions		 EXP Angiotensin II results in decreased expression of TFAM protein
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of TFAM protein]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of TFAM protein]]		 CTD PMID:37269933 NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,356,197...17,368,292 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO naoxintong inhibits the reaction [Angiotensin II results in increased expression of TNF mRNA] CTD PMID:38230784 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      biological role 19856
        molecular messenger 18671
          hormone 18505
            peptide hormone 151
              angiotensin 46
                angiotensin II 46
                  Ile(5)-angiotensin II 28
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      carbon group element atom 19763
                        carbon atom 19760
                          organic molecular entity 19760
                            heteroorganic entity 19521
                              organochalcogen compound 19282
                                organooxygen compound 19197
                                  carbon oxoacid 18676
                                    carboxylic acid 18673
                                      carboacyl group 17700
                                        univalent carboacyl group 17700
                                          carbamoyl group 17545
                                            carboxamide 17545
                                              peptide 11445
                                                peptide hormone 151
                                                  angiotensin 46
                                                    angiotensin II 46
                                                      Ile(5)-angiotensin II 28
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