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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tryptophan derivative
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Accession:CHEBI:27164 term browser browse the term
Definition:An amino acid derivative resulting from reaction of tryptophan at the amino group or the carboxy group, or from the replacement of any hydrogen of tryptophan by a heteroatom. The definition normally excludes peptides containing tryptophan residues.
Synonyms:related_synonym: tryptophan derivatives

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1-methyltryptophan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ido2 indoleamine 2,3-dioxygenase 2 decreases activity ISO 1-methyltryptophan results in decreased activity of IDO2 protein CTD PMID:32289347 NCBI chr16:72,232,852...72,291,227
Ensembl chr16:72,268,943...72,289,156 		JBrowse link
5-hydroxytryptophan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddc dopa decarboxylase multiple interactions EXP [DDC protein results in decreased carboxylation of 5-Hydroxytryptophan] which results in increased chemical synthesis of Serotonin CTD PMID:32243540 NCBI chr14:91,905,919...91,996,816
Ensembl chr14:91,905,919...91,996,774 		JBrowse link
G Tph1 tryptophan hydroxylase 1 multiple interactions EXP [TPH1 protein results in increased hydroxylation of Tryptophan] which results in increased chemical synthesis of 5-Hydroxytryptophan CTD PMID:32243540 NCBI chr 1:102,669,868...102,699,442
Ensembl chr 1:102,669,868...102,699,442 		JBrowse link
ilomastat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il13 interleukin 13 multiple interactions EXP ilomastat inhibits the reaction [Mustard Gas results in increased expression of IL13 protein] CTD PMID:18852015 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466 		JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions EXP ilomastat affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP1 protein]; ilomastat inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP1 mRNA] CTD PMID:18837084 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP ilomastat affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TIMP1 mRNA]; ilomastat affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TIMP1 protein] CTD PMID:18837084 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    chemical entity 19841
      atom 19839
        nonmetal atom 19720
          nitrogen atom 18613
            nitrogen molecular entity 18613
              organonitrogen compound 18386
                amino acid derivative 10957
                  tryptophan derivative 6
                    1-methyltryptophan 1
                    2-imino-3-(indol-3-yl)propanoic acid + 0
                    5-bromotryptophan 0
                    5-fluorotryptophan 0
                    5-methyltryptophan + 0
                    6-chlorotryptophan + 0
                    7-chlorotryptophan + 0
                    D-tryptophan derivative + 0
                    Dimethylallyltryptophan 0
                    L-tryptophan derivative + 3
                    L-tryptophanamide + 0
                    N-acetyltryptophan 0
                    N-acetyltryptophyl-N(1)-\{3-[1-(N-acetyltryptophylvalyl)pyrrolidin-2-yl]-1-benzyl-2,3-dihydroxypropyl\}valinamide 0
                    N-malonyltryptophan 0
                    hydroxytryptophan + 2
                    peptidyl-tryptophan 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic group 18537
                              organic divalent group 18528
                                organodiyl group 18528
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18113
                                        amino acid 14108
                                          polar amino acid 10656
                                            tryptophan 9
                                              tryptophan derivative 6
                                                1-methyltryptophan 1
                                                2-imino-3-(indol-3-yl)propanoic acid + 0
                                                5-bromotryptophan 0
                                                5-fluorotryptophan 0
                                                5-methyltryptophan + 0
                                                6-chlorotryptophan + 0
                                                7-chlorotryptophan + 0
                                                D-tryptophan derivative + 0
                                                Dimethylallyltryptophan 0
                                                L-tryptophan derivative + 3
                                                L-tryptophanamide + 0
                                                N-acetyltryptophan 0
                                                N-acetyltryptophyl-N(1)-\{3-[1-(N-acetyltryptophylvalyl)pyrrolidin-2-yl]-1-benzyl-2,3-dihydroxypropyl\}valinamide 0
                                                N-malonyltryptophan 0
                                                hydroxytryptophan + 2
                                                peptidyl-tryptophan 0
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