CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: triose
Accession: CHEBI:27137
browse the term
Definition: A monosaccharide containing three carbon atoms, which is important in respiration. Only two trioses occur naturally: the aldotriose glyceraldehyde and the ketotriose dihydroxyacetone.
Synonyms: related_synonym: trioses
G
Akr1b1
aldo-keto reductase family 1 member B
increases reduction
ISO
AKR1B1 protein results in increased reduction of Glyceraldehyde
CTD
PMID:19014918
NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
G
Akr1b10
aldo-keto reductase family 1 member B10
multiple interactions increases reduction increases metabolic processing
ISO
[AKR1B10 protein co-treated with NADP] affects the reduction of Glyceraldehyde; ciprofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; Fenofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; fenofibric acid inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; pirinixic acid inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; sorbinil inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; zopolrestat inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde] AKR1B10 protein results in increased metabolism of Glyceraldehyde
CTD
PMID:17329238 PMID:18325492 PMID:19014918 PMID:19028477
NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
G
Akr1b8
aldo-keto reductase family 1, member B8
increases metabolic processing
ISO
AKR1B15 protein results in increased metabolism of Glyceraldehyde
CTD
PMID:21276782
NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
G
Aldh2
aldehyde dehydrogenase 2 family member
multiple interactions
EXP
[Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyceraldehyde; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyceraldehyde
CTD
PMID:21376711
NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
G
Dhrs3
dehydrogenase/reductase 3
increases metabolic processing
ISO
DHRS3 protein results in increased metabolism of Glyceraldehyde
CTD
PMID:25451588
NCBI chr 5:162,809,090...162,843,385
Ensembl chr 5:162,808,646...162,843,383
G
Plcb1
phospholipase C beta 1
multiple interactions
EXP
PLCB1 protein promotes the reaction [Glyceraldehyde results in increased abundance of Inositol Phosphates]
CTD
PMID:11377826
NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545
G
Atm
ATM serine/threonine kinase
decreases expression
ISO
Dihydroxyacetone results in decreased expression of ATM mRNA
CTD
PMID:32506039
NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
G
Casp3
caspase 3
increases cleavage
ISO
Dihydroxyacetone results in increased cleavage of CASP3 protein
CTD
PMID:29193605
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
G
Ccl21
C-C motif chemokine ligand 21
decreases expression
ISO
Dihydroxyacetone results in decreased expression of CCL21 mRNA
CTD
PMID:32506039
NCBI chr 5:58,197,678...58,198,782
Ensembl chr 5:58,197,680...58,198,782
G
Ccl3
C-C motif chemokine ligand 3
decreases expression
ISO
Dihydroxyacetone results in decreased expression of CCL3 mRNA
CTD
PMID:32506039
NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
G
Ccl4
C-C motif chemokine ligand 4
decreases expression
ISO
Dihydroxyacetone results in decreased expression of CCL4 mRNA
CTD
PMID:32506039
NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
G
Ccnc
cyclin C
increases expression
ISO
Dihydroxyacetone results in increased expression of CCNC mRNA
CTD
PMID:32506039
NCBI chr 5:35,865,598...35,883,732
Ensembl chr 5:35,865,605...35,883,706
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
decreases expression
ISO
Dihydroxyacetone results in decreased expression of CDKN1A mRNA
CTD
PMID:32506039
NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
G
Cel
carboxyl ester lipase
increases expression
ISO
Dihydroxyacetone results in increased expression of CEL protein
CTD
PMID:32506039
NCBI chr 3:7,134,021...7,141,522
Ensembl chr 3:7,134,021...7,141,522
G
Chek2
checkpoint kinase 2
decreases expression
ISO
Dihydroxyacetone results in decreased expression of CHEK2 mRNA
CTD
PMID:32506039
NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
G
Cryab
crystallin, alpha B
increases expression
ISO
Dihydroxyacetone results in increased expression of CRYAB mRNA; Dihydroxyacetone results in increased expression of CRYAB protein
CTD
PMID:32506039
NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
G
Csf2
colony stimulating factor 2
increases expression
ISO
Dihydroxyacetone results in increased expression of CSF2 mRNA
CTD
PMID:32506039
NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases expression
ISO
Dihydroxyacetone results in decreased expression of CYP1A1 mRNA
CTD
PMID:32506039
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
decreases expression
ISO
Dihydroxyacetone results in decreased expression of CYP2E1 mRNA
CTD
PMID:32506039
NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
G
Cyp7a1
cytochrome P450 family 7 subfamily A member 1
decreases expression
ISO
Dihydroxyacetone results in decreased expression of CYP7A1 mRNA
CTD
PMID:32506039
NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
G
Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
Dihydroxyacetone results in increased expression of DDIT3 mRNA
CTD
PMID:32506039
NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
G
Dnajb4
DnaJ heat shock protein family (Hsp40) member B4
increases expression
ISO
Dihydroxyacetone results in increased expression of DNAJB4 mRNA
CTD
PMID:32506039
NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
G
E2f1
E2F transcription factor 1
increases expression
ISO
Dihydroxyacetone results in increased expression of E2F1 mRNA
CTD
PMID:32506039
NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
G
Egr1
early growth response 1
affects expression
ISO
Dihydroxyacetone affects the expression of EGR1 mRNA
CTD
PMID:32506039
NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
G
Eif2s1
eukaryotic translation initiation factor 2 subunit alpha
increases phosphorylation
ISO
Dihydroxyacetone results in increased phosphorylation of EIF2S1 protein
CTD
PMID:32506039
NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
G
Ephx2
epoxide hydrolase 2
decreases expression
ISO
Dihydroxyacetone results in decreased expression of EPHX2 mRNA
CTD
PMID:32506039
NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
G
Ercc3
ERCC excision repair 3, TFIIH core complex helicase subunit
increases expression
ISO
Dihydroxyacetone results in increased expression of ERCC3 mRNA
CTD
PMID:32506039
NCBI chr18:25,037,668...25,068,380
Ensembl chr18:25,037,625...25,068,389
G
Faslg
Fas ligand
affects expression
ISO
Dihydroxyacetone affects the expression of FASLG mRNA
CTD
PMID:32506039
NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
G
Fmo1
flavin containing dimethylaniline monoxygenase 1
decreases expression
ISO
Dihydroxyacetone results in decreased expression of FMO1 mRNA
CTD
PMID:32506039
NCBI chr13:80,712,885...80,745,095
Ensembl chr13:80,712,882...80,745,347
G
Gdf15
growth differentiation factor 15
decreases expression
ISO
Dihydroxyacetone results in decreased expression of GDF15 mRNA
CTD
PMID:32506039
NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
G
Glo1
glyoxalase 1
affects response to substance
ISO
GLO1 protein affects the susceptibility to Dihydroxyacetone
CTD
PMID:32506039
NCBI chr20:9,273,589...9,291,608
Ensembl chr20:9,273,594...9,291,610
G
H2ax
H2A.X variant histone
increases expression
ISO
Dihydroxyacetone results in increased expression of H2AX protein
CTD
PMID:32506039
NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
G
Hmox1
heme oxygenase 1
increases expression
ISO
Dihydroxyacetone results in increased expression of HMOX1 mRNA; Dihydroxyacetone results in increased expression of HMOX1 protein
CTD
PMID:32506039
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
G
Hspa1a
heat shock protein family A (Hsp70) member 1A
increases expression
ISO
Dihydroxyacetone results in increased expression of HSPA1A mRNA
CTD
PMID:32506039
NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
G
Hspa2
heat shock protein family A (Hsp70) member 2
increases expression
ISO
Dihydroxyacetone results in increased expression of HSPA2 mRNA
CTD
PMID:32506039
NCBI chr 6:99,433,575...99,436,288
Ensembl chr 6:99,433,550...99,436,289
G
Hspb1
heat shock protein family B (small) member 1
increases phosphorylation
ISO
Dihydroxyacetone results in increased phosphorylation of HSPB1 protein
CTD
PMID:32506039
NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
G
Hspd1
heat shock protein family D (Hsp60) member 1
increases expression
ISO
Dihydroxyacetone results in increased expression of HSPD1 mRNA
CTD
PMID:32506039
NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
G
Hspe1
heat shock protein family E (Hsp10) member 1
increases expression
ISO
Dihydroxyacetone results in increased expression of HSPE1 mRNA
CTD
PMID:32506039
NCBI chr 9:61,691,246...61,724,948
Ensembl chr 9:61,692,154...61,694,599
G
Il6
interleukin 6
increases expression
ISO
Dihydroxyacetone results in increased expression of IL6 mRNA
CTD
PMID:32506039
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
G
LOC686035
similar to heat shock 70kDa protein 6 (HSP70B)
increases expression
ISO
Dihydroxyacetone results in increased expression of HSPA6 protein
CTD
PMID:32506039
NCBI chr13:89,408,703...89,411,500
G
Mapk1
mitogen activated protein kinase 1
increases phosphorylation
ISO
Dihydroxyacetone results in increased phosphorylation of MAPK1 protein
CTD
PMID:32506039
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
G
Mapk3
mitogen activated protein kinase 3
increases phosphorylation
ISO
Dihydroxyacetone results in increased phosphorylation of MAPK3 protein
CTD
PMID:32506039
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
G
Mmp10
matrix metallopeptidase 10
decreases secretion
ISO
Dihydroxyacetone results in decreased secretion of MMP10 protein
CTD
PMID:30959092
NCBI chr 8:5,734,348...5,742,243
Ensembl chr 8:5,734,348...5,742,243
G
Mmp13
matrix metallopeptidase 13
decreases secretion
ISO
Dihydroxyacetone results in decreased secretion of MMP13 protein
CTD
PMID:30959092
NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
G
Mt2A
metallothionein 2A
decreases expression
ISO
Dihydroxyacetone results in decreased expression of MT2A mRNA
CTD
PMID:32506039
NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
G
Muc5ac
mucin 5AC, oligomeric mucus/gel-forming
decreases secretion
ISO
Dihydroxyacetone results in decreased secretion of MUC5AC protein
CTD
PMID:30959092
NCBI chr 1:214,725,482...214,756,653
G
Nfe2l2
nuclear factor, erythroid 2-like 2
increases expression
ISO
Dihydroxyacetone results in increased expression of NFE2L2 protein
CTD
PMID:32506039
NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
G
Nfkb1
nuclear factor kappa B subunit 1
decreases expression
ISO
Dihydroxyacetone results in decreased expression of NFKB1 mRNA
CTD
PMID:32506039
NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
G
Nos2
nitric oxide synthase 2
decreases expression
ISO
Dihydroxyacetone results in decreased expression of NOS2 mRNA
CTD
PMID:32506039
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
G
Oat
ornithine aminotransferase
multiple interactions
EXP
Dihydroxyacetone inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]
CTD
PMID:2827574
NCBI chr 1:204,562,289...204,582,070
Ensembl chr 1:204,562,289...204,582,070
G
Parp1
poly (ADP-ribose) polymerase 1
increases cleavage
ISO
Dihydroxyacetone results in increased cleavage of PARP1 protein
CTD
PMID:29193605
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
G
Pcna
proliferating cell nuclear antigen
increases expression
ISO
Dihydroxyacetone results in increased expression of PCNA mRNA
CTD
PMID:32506039
NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
G
Tnf
tumor necrosis factor
increases expression
ISO
Dihydroxyacetone results in increased expression of TNF mRNA
CTD
PMID:32506039
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
G
Tnfrsf1a
TNF receptor superfamily member 1A
affects expression
ISO
Dihydroxyacetone affects the expression of TNFRSF1A mRNA
CTD
PMID:32506039
NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
G
Tnfsf10
TNF superfamily member 10
decreases expression
ISO
Dihydroxyacetone results in decreased expression of TNFSF10 mRNA
CTD
PMID:32506039
NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
G
Ung
uracil-DNA glycosylase
decreases expression
ISO
Dihydroxyacetone results in decreased expression of UNG mRNA
CTD
PMID:32506039
NCBI chr12:48,246,593...48,255,547
Ensembl chr12:48,246,569...48,254,822
G
Xrcc2
X-ray repair cross complementing 2
increases expression
ISO
Dihydroxyacetone results in increased expression of XRCC2 mRNA; Dihydroxyacetone results in increased expression of XRCC2 protein
CTD
PMID:32506039
NCBI chr 4:5,842,013...5,860,516
Ensembl chr 4:5,841,998...5,860,527
G
Idh2
isocitrate dehydrogenase (NADP(+)) 2
increases abundance multiple interactions
ISO
IDH2 protein mutant form results in increased abundance of Dihydroxyacetone Phosphate Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Dihydroxyacetone Phosphate]
CTD
PMID:27469509
NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
G
Tpi1
triosephosphate isomerase 1
affects metabolic processing
EXP
TPI1 protein affects the metabolism of Dihydroxyacetone Phosphate
CTD
PMID:14762718
NCBI chr 4:157,328,375...157,331,905
Ensembl chr 4:157,328,379...157,331,905 Ensembl chr 9:157,328,379...157,331,905
G
Akr1b1
aldo-keto reductase family 1 member B
increases reduction
ISO
AKR1B1 protein results in increased reduction of Glyceraldehyde
CTD
PMID:19014918
NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
G
Akr1b10
aldo-keto reductase family 1 member B10
multiple interactions increases metabolic processing increases reduction
ISO
[AKR1B10 protein co-treated with NADP] affects the reduction of Glyceraldehyde; ciprofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; Fenofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; fenofibric acid inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; pirinixic acid inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; sorbinil inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; zopolrestat inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde] AKR1B10 protein results in increased metabolism of Glyceraldehyde
CTD
PMID:17329238 PMID:18325492 PMID:19014918 PMID:19028477
NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
G
Akr1b8
aldo-keto reductase family 1, member B8
increases metabolic processing
ISO
AKR1B15 protein results in increased metabolism of Glyceraldehyde
CTD
PMID:21276782
NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
G
Aldh2
aldehyde dehydrogenase 2 family member
multiple interactions
EXP
[Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyceraldehyde; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyceraldehyde
CTD
PMID:21376711
NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
G
Dhrs3
dehydrogenase/reductase 3
increases metabolic processing
ISO
DHRS3 protein results in increased metabolism of Glyceraldehyde
CTD
PMID:25451588
NCBI chr 5:162,809,090...162,843,385
Ensembl chr 5:162,808,646...162,843,383
G
Plcb1
phospholipase C beta 1
multiple interactions
EXP
PLCB1 protein promotes the reaction [Glyceraldehyde results in increased abundance of Inositol Phosphates]
CTD
PMID:11377826
NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545
G
Gapdh
glyceraldehyde-3-phosphate dehydrogenase
multiple interactions
ISO
[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog; Adenosine Diphosphate inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]; Adenosine Triphosphate inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]; NAD analog inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]; NADP inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]
CTD
PMID:15788719
NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
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