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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:trimethylarsine oxide
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Accession:CHEBI:27131 term browser browse the term
Definition:An arsine oxide that has formula C3H9AsO.
Synonyms:exact_synonym: trimethylarsane oxide
 related_synonym: (CH3)3As=O;   Formula=C3H9AsO;   InChI=1S/C3H9AsO/c1-4(2,3)5/h1-3H3;   InChIKey=JWOWJQPAYGEFFK-UHFFFAOYSA-N;   SMILES=C[As](C)(C)=O
 xref: Beilstein:1734788;   CAS:4964-14-1;   Gmelin:164299
 xref_mesh: MESH:C052920
 xref: UM-BBD_compID:c0754


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trimethylarsine oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases expression ISO trimethylarsine oxide results in increased expression of ABCB1A mRNA; trimethylarsine oxide results in increased expression of ABCB1A protein CTD PMID:16436460 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) increases expression ISO trimethylarsine oxide results in increased expression of ABCC1 mRNA; trimethylarsine oxide results in increased expression of ABCC1 protein CTD PMID:16436460 NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 increases expression ISO trimethylarsine oxide results in increased expression of ABCC2 mRNA; trimethylarsine oxide results in increased expression of ABCC2 protein CTD PMID:16436460 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594 		JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 increases expression ISO trimethylarsine oxide results in increased expression of ABCC3 mRNA; trimethylarsine oxide results in increased expression of ABCC3 protein CTD PMID:16436460 NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253 		JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions ISO
EXP		 trimethylarsine oxide affects the localization of and results in increased activity of AHR protein
AHR mutant form inhibits the reaction [trimethylarsine oxide results in increased expression of CYP1A1 protein]; trimethylarsine oxide results in decreased expression of and affects the localization of AHR protein		 CTD PMID:24161444 PMID:26144063 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152 		JBrowse link
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 increases expression ISO trimethylarsine oxide results in increased expression of ALDH1A1 mRNA CTD PMID:17481689 NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442 		JBrowse link
G AS3MT arsenite methyltransferase increases chemical synthesis
multiple interactions		 ISO AS3MT protein results in increased chemical synthesis of trimethylarsine oxide
Glutathione affects the reaction [AS3MT protein results in increased chemical synthesis of trimethylarsine oxide]		 CTD PMID:15606138 NCBI chr10:102,869,470...102,901,899
Ensembl chr10:102,869,470...102,901,899 		JBrowse link
G CASP3 caspase 3 increases expression ISO trimethylarsine oxide results in increased expression of CASP3 mRNA CTD PMID:17481689 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CCND1 cyclin D1 increases expression ISO trimethylarsine oxide results in increased expression of CCND1 mRNA CTD PMID:17481689 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CCNE1 cyclin E1 increases expression ISO trimethylarsine oxide results in increased expression of CCNE1 mRNA CTD PMID:17481689 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312 		JBrowse link
G CDH1 cadherin 1 increases expression ISO trimethylarsine oxide results in increased expression of CDH1 mRNA CTD PMID:17481689 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537 		JBrowse link
G CDH2 cadherin 2 increases expression ISO trimethylarsine oxide results in increased expression of CDH2 mRNA CTD PMID:17481689 NCBI chr18:27,932,879...28,177,130
Ensembl chr18:27,932,879...28,177,946 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 affects expression
increases expression
multiple interactions		 ISO
EXP		 trimethylarsine oxide affects the expression of CYP1A1 mRNA
trimethylarsine oxide results in increased expression of CYP1A1 mRNA; trimethylarsine oxide results in increased expression of CYP1A1 protein
trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; trimethylarsine oxide results in increased expression of and results in increased activity of CYP1A1 protein
AHR mutant form inhibits the reaction [trimethylarsine oxide results in increased expression of CYP1A1 protein]; trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; trimethylarsine oxide results in increased expression of and results in increased activity of CYP1A1 protein		 CTD PMID:17481689 PMID:24161444 PMID:26042454 PMID:26144063 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases expression ISO trimethylarsine oxide results in increased expression of CYP1A2 mRNA
trimethylarsine oxide results in increased expression of CYP1A2 mRNA; trimethylarsine oxide results in increased expression of CYP1A2 protein		 CTD PMID:17481689 PMID:26144063 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 multiple interactions
increases expression		 ISO trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1B1 protein]; trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 protein]; trimethylarsine oxide results in increased expression of and results in increased activity of CYP1B1 protein
trimethylarsine oxide results in increased expression of CYP1B1 mRNA		 CTD PMID:26042454 PMID:26144063 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902 		JBrowse link
G CYP2C18 cytochrome P450 family 2 subfamily C member 18 increases expression ISO trimethylarsine oxide results in increased expression of CYP2C11 mRNA CTD PMID:17481689 NCBI chr10:94,683,729...94,736,190
Ensembl chr10:94,683,729...94,736,190 		JBrowse link
G DNMT1 DNA methyltransferase 1 decreases expression ISO trimethylarsine oxide results in decreased expression of DNMT1 mRNA CTD PMID:17481689 NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,342...10,231,286 		JBrowse link
G FASLG Fas ligand increases expression ISO trimethylarsine oxide results in increased expression of FASLG mRNA CTD PMID:17481689 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876 		JBrowse link
G GJB1 gap junction protein beta 1 increases expression ISO trimethylarsine oxide results in increased expression of GJB1 mRNA CTD PMID:17481689 NCBI chr  X:71,215,239...71,225,516
Ensembl chr  X:71,212,811...71,225,516 		JBrowse link
G GSTA2 glutathione S-transferase alpha 2 decreases expression
increases expression		 ISO trimethylarsine oxide results in decreased expression of GSTA2 mRNA; trimethylarsine oxide results in decreased expression of GSTA2 protein
trimethylarsine oxide results in increased expression of GSTA2 mRNA		 CTD PMID:16436460 PMID:17481689 NCBI chr 6:52,750,087...52,763,475
Ensembl chr 6:52,750,087...52,763,475 		JBrowse link
G GSTA3 glutathione S-transferase alpha 3 increases expression ISO trimethylarsine oxide results in increased expression of GSTA1 mRNA CTD PMID:26144063 NCBI chr 6:52,896,646...52,909,698
Ensembl chr 6:52,896,639...52,909,698 		JBrowse link
G GSTM1 glutathione S-transferase mu 1 increases expression ISO trimethylarsine oxide results in increased expression of GSTM1 mRNA; trimethylarsine oxide results in increased expression of GSTM1 protein CTD PMID:16436460 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 increases expression ISO trimethylarsine oxide results in increased expression of GSTP1 mRNA CTD PMID:17481689 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656 		JBrowse link
G HMOX1 heme oxygenase 1 increases expression ISO trimethylarsine oxide results in increased expression of HMOX1 mRNA; trimethylarsine oxide results in increased expression of HMOX1 protein CTD PMID:26144063 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 increases expression ISO trimethylarsine oxide results in increased expression of ITIH3 mRNA CTD PMID:17481689 NCBI chr 3:52,794,796...52,808,797
Ensembl chr 3:52,794,768...52,808,799 		JBrowse link
G KRT18 keratin 18 decreases expression ISO trimethylarsine oxide results in decreased expression of KRT18 mRNA CTD PMID:17481689 NCBI chr12:52,948,855...52,952,906
Ensembl chr12:52,948,871...52,952,906 		JBrowse link
G MAPK14 mitogen-activated protein kinase 14 increases expression ISO trimethylarsine oxide results in increased expression of MAPK14 mRNA CTD PMID:17481689 NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,782...36,111,236 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 decreases expression ISO trimethylarsine oxide results in decreased expression of MAPK8 mRNA CTD PMID:17481689 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP NFE2L2 mutant form inhibits the reaction [trimethylarsine oxide results in increased expression of NQO1 protein]; trimethylarsine oxide results in increased expression of and affects the localization of NFE2L2 protein CTD PMID:24161444 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression		 EXP
ISO		 NFE2L2 mutant form inhibits the reaction [trimethylarsine oxide results in increased expression of NQO1 protein]; trimethylarsine oxide promotes the reaction [sulforaphane results in increased expression of and results in increased activity of NQO1 protein]; trimethylarsine oxide promotes the reaction [sulforaphane results in increased expression of NQO1 mRNA]; trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of NQO1 protein]; trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]; trimethylarsine oxide results in increased expression of and results in increased activity of NQO1 protein
trimethylarsine oxide results in increased expression of NQO1 mRNA; trimethylarsine oxide results in increased expression of NQO1 protein		 CTD PMID:24161444 PMID:26042454 PMID:26144063 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G OGG1 8-oxoguanine DNA glycosylase increases expression ISO trimethylarsine oxide results in increased expression of OGG1 mRNA CTD PMID:17481689 NCBI chr 3:9,749,952...9,783,108
Ensembl chr 3:9,749,944...9,788,219 		JBrowse link
G PCNA proliferating cell nuclear antigen increases expression ISO trimethylarsine oxide results in increased expression of PCNA mRNA CTD PMID:17481689 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626 		JBrowse link
G PRKCA protein kinase C alpha increases expression ISO trimethylarsine oxide results in increased expression of PRKCA mRNA CTD PMID:17481689 NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743 		JBrowse link
G PRKCG protein kinase C gamma increases expression ISO trimethylarsine oxide results in increased expression of PRKCG mRNA CTD PMID:17481689 NCBI chr19:53,881,094...53,907,652
Ensembl chr19:53,879,190...53,907,652 		JBrowse link
G TNF tumor necrosis factor decreases secretion ISO trimethylarsine oxide results in decreased secretion of TNF protein CTD PMID:9548797 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    chemical entity 26024
      atom 26009
        metalloid atom 16404
          arsenic atom 15087
            arsenic molecular entity 15097
              arsine oxides 106
                trimethylarsine oxide 34
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      p-block molecular entity 25829
                        pnictogen molecular entity 23341
                          arsenic molecular entity 15097
                            arsine oxides 106
                              trimethylarsine oxide 34
paths to the root