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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:trimethoxyflavone
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Accession:CHEBI:27124 term browser browse the term
Definition:A methoxyflavone that is flavone substituted by three methoxy groups.
Synonyms:related_synonym: trimethoxyflavones

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5,6,7-trimethoxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of FOS protein] CTD PMID:24161485 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein] CTD PMID:24161485 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein] CTD PMID:24161485 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of JUN protein] CTD PMID:24161485 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:24161485 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; [5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]] which results in decreased abundance of Nitric Oxide CTD PMID:24161485 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]; [5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]] which results in decreased abundance of Dinoprostone CTD PMID:24161485 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of RELA protein] CTD PMID:24161485 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of STAT1 protein]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT1 protein] CTD PMID:24161485 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of STAT3 protein]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT3 protein] CTD PMID:24161485 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein] CTD PMID:24161485 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
eupatilin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CCL2 mRNA] CTD PMID:21565208 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases activity
multiple interactions		 ISO eupatilin results in increased activity of CYP3A4 protein
[[eupatilin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [eupatilin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam		 CTD PMID:31756459 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL1B mRNA] CTD PMID:21565208 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA] CTD PMID:21565208 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:21565208 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of NOS2 mRNA]; eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of NOS2 protein] CTD PMID:21565208 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 mRNA]; eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 protein] CTD PMID:21565208 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 affects the localization of RELA protein] CTD PMID:21565208 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF mRNA] CTD PMID:21565208 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
eupatorin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases response to substance
increases metabolic processing
decreases activity
increases expression		 ISO CYP1A1 protein results in increased susceptibility to eupatorin
CYP1A1 protein results in increased metabolism of eupatorin analog
eupatorin analog results in decreased activity of CYP1A1 protein
eupatorin results in increased expression of CYP1A1 mRNA		 CTD PMID:18454852 PMID:19601638 PMID:21482471 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing
increases expression
decreases activity		 ISO CYP1B1 protein results in increased metabolism of eupatorin analog
eupatorin results in increased expression of CYP1B1 mRNA
eupatorin results in decreased activity of CYP1B1 protein		 CTD PMID:19601638 PMID:21482471 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO eupatorin results in decreased activity of CYP2C19 protein CTD PMID:21093571 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO eupatorin results in decreased activity of CYP2D6 protein CTD PMID:21276781 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity ISO eupatorin results in decreased activity of CYP3A4 protein CTD PMID:21276781 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
nevadensin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
increases activity		 EXP 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [nevadensin results in increased activity of ACHE protein] CTD PMID:31034797 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    chemical entity 19883
      atom 19881
        nonmetal atom 19760
          oxygen atom 19425
            oxygen molecular entity 19425
              organooxygen compound 18886
                ether 16119
                  methoxyflavone 416
                    trimethoxyflavone 18
                      2-(4-hydroxyphenyl)-5,6,7-trimethoxy-4H-1-benzopyran-4-one 0
                      3',4',5'-O-trimethyltricetin 0
                      3',4',5-trihydroxy-3,6,7-trimethoxyflavone 0
                      3',5,7-trihydroxy-3,4',5'-trimethoxyflavone 0
                      3',5-dihydroxy-3,4',7-trimethoxyflavone 0
                      3,3',5'-trimethylmyricetin 0
                      5,6,3'-trihydroxy-7,8,4'-trimethoxyflavone 0
                      5,6,7-trimethoxyflavone 11
                      6-hydroxy-4',5,7-trimethoxyflavone 0
                      7,3',5'-trimethylmyricetin 0
                      7-methoxytricin 0
                      acerosin 0
                      arcapillin 0
                      centaureidin 0
                      chlorflavonin 0
                      chrysosplenol C 0
                      cirsilineol 0
                      diplotrin C 0
                      eupatilin 9
                      eupatin 0
                      eupatorin 5
                      galangin 3,5,7-trimethyl ether 0
                      hernancorizin 0
                      nevadensin 1
                      oxyayanin A 0
                      oxyayanin B 0
                      pachypodol 0
                      quercetin 7,3',4'-trimethyl ether 0
                      santin 0
                      tambulin 0
                      thymonin 0
                      xanthomicrol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    p-block element atom 19771
                      carbon group element atom 19679
                        carbon atom 19668
                          organic molecular entity 19668
                            organic molecule 19596
                              organic cyclic compound 19407
                                organic heterocyclic compound 18517
                                  oxacycle 17299
                                    benzopyran 10156
                                      1-benzopyran 9872
                                        flavonoid 6379
                                          flavones 4174
                                            methoxyflavone 416
                                              trimethoxyflavone 18
                                                2-(4-hydroxyphenyl)-5,6,7-trimethoxy-4H-1-benzopyran-4-one 0
                                                3',4',5'-O-trimethyltricetin 0
                                                3',4',5-trihydroxy-3,6,7-trimethoxyflavone 0
                                                3',5,7-trihydroxy-3,4',5'-trimethoxyflavone 0
                                                3',5-dihydroxy-3,4',7-trimethoxyflavone 0
                                                3,3',5'-trimethylmyricetin 0
                                                5,6,3'-trihydroxy-7,8,4'-trimethoxyflavone 0
                                                5,6,7-trimethoxyflavone 11
                                                6-hydroxy-4',5,7-trimethoxyflavone 0
                                                7,3',5'-trimethylmyricetin 0
                                                7-methoxytricin 0
                                                acerosin 0
                                                arcapillin 0
                                                centaureidin 0
                                                chlorflavonin 0
                                                chrysosplenol C 0
                                                cirsilineol 0
                                                diplotrin C 0
                                                eupatilin 9
                                                eupatin 0
                                                eupatorin 5
                                                galangin 3,5,7-trimethyl ether 0
                                                hernancorizin 0
                                                nevadensin 1
                                                oxyayanin A 0
                                                oxyayanin B 0
                                                pachypodol 0
                                                quercetin 7,3',4'-trimethyl ether 0
                                                santin 0
                                                tambulin 0
                                                thymonin 0
                                                xanthomicrol 0
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