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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:trihydroxyflavone
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Accession:CHEBI:27116 term browser browse the term
Definition:Any hydroxyflavone carrying three hydroxy groups at unspecified positions.
Synonyms:related_synonym: trihydroxyflavones


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3',4',5-trihydroxy-3,7-dimethoxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnb1 cyclin B1 affects phosphorylation
increases expression
ISO 5,7,3'-trihydroxy-3,4'-dimethoxyflavone affects the phosphorylation of CCNB1 protein
5,7,3'-trihydroxy-3,4'-dimethoxyflavone results in increased expression of CCNB1 protein
CTD PMID:21229608 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cdc25c cell division cycle 25C affects phosphorylation ISO 5,7,3'-trihydroxy-3,4'-dimethoxyflavone affects the phosphorylation of CDC25C protein CTD PMID:21229608 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdk1 cyclin-dependent kinase 1 affects phosphorylation ISO 5,7,3'-trihydroxy-3,4'-dimethoxyflavone affects the phosphorylation of CDK1 protein CTD PMID:21229608 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO 5,7,3'-trihydroxy-3,4'-dimethoxyflavone results in increased expression of CDKN1A protein CTD PMID:21229608 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Foxm1 forkhead box M1 affects phosphorylation ISO 5,7,3'-trihydroxy-3,4'-dimethoxyflavone affects the phosphorylation of FOXM1 protein CTD PMID:21229608 NCBI chr 4:161,685,236...161,697,633
Ensembl chr 4:161,685,258...161,696,305
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 increases activity ISO 5,7,3'-trihydroxy-3,4'-dimethoxyflavone results in increased activity of SMPD1 protein CTD PMID:21229608 NCBI chr 1:170,383,682...170,387,525
Ensembl chr 1:170,383,682...170,387,524
JBrowse link
3',5'-di-O-methyltricetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO tricin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] CTD PMID:16552572 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
4',5,7-trihydroxy-3'-methoxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity ISO chrysoeriol results in decreased activity of ABCC1 protein CTD PMID:15670588 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO chrysoeriol inhibits the reaction [Benzo(a)pyrene binds to AHR protein] CTD PMID:20553787 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions ISO chrysoeriol inhibits the reaction [Hydrogen Peroxide results in decreased expression of BGLAP protein] CTD PMID:20981859 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] CTD PMID:20553787 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA] CTD PMID:20553787 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA] CTD PMID:20553787 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Il6 interleukin 6 multiple interactions ISO chrysoeriol inhibits the reaction [Hydrogen Peroxide results in increased expression of IL6 protein] CTD PMID:20981859 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mtnr1a melatonin receptor 1A affects binding ISO chrysoeriol binds to MTNR1A protein CTD PMID:20399199 NCBI chr16:50,339,358...50,358,809
Ensembl chr16:50,339,358...50,358,809
JBrowse link
G Mtnr1b melatonin receptor 1B affects binding ISO chrysoeriol binds to MTNR1B protein CTD PMID:20399199 NCBI chr 8:14,359,270...14,373,894
Ensembl chr 8:14,359,270...14,373,894
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 multiple interactions ISO chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3] CTD PMID:20399199 NCBI chr17:32,131,847...32,158,559
Ensembl chr17:32,132,347...32,158,538
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO chrysoeriol inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFSF11 protein] CTD PMID:20981859 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
5,6,7-trimethoxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of FOS protein] CTD PMID:24161485 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein] CTD PMID:24161485 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein] CTD PMID:24161485 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of JUN protein] CTD PMID:24161485 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:24161485 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; [5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]] which results in decreased abundance of Nitric Oxide CTD PMID:24161485 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]; [5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]] which results in decreased abundance of Dinoprostone CTD PMID:24161485 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of RELA protein] CTD PMID:24161485 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of STAT1 protein]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT1 protein] CTD PMID:24161485 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of STAT3 protein]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT3 protein] CTD PMID:24161485 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein] CTD PMID:24161485 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
5,7-dihydroxy-4'-methoxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing
increases expression
decreases activity
ISO CYP1A1 protein results in increased metabolism of acacetin
acacetin results in increased expression of CYP1A1 mRNA
acacetin results in decreased activity of CYP1A1 protein
CTD PMID:10781868, PMID:21053930, PMID:21482471, PMID:31621310 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO acacetin results in decreased activity of CYP1A2 protein CTD PMID:21053930 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing
increases expression
decreases activity
multiple interactions
ISO CYP1B1 protein results in increased metabolism of acacetin
acacetin results in increased expression of CYP1B1 mRNA
acacetin results in decreased activity of CYP1B1 protein
acacetin binds to and results in decreased activity of CYP1B1 protein
CTD PMID:10781868, PMID:21053930, PMID:21482471, PMID:31621310 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
increases expression
multiple interactions
ISO acacetin results in increased activity of NR1I2 protein
acacetin results in increased expression of NR1I2 mRNA
acacetin results in increased activity of and results in increased expression of NR1I2 protein; sulforafan inhibits the reaction [acacetin results in increased activity of NR1I2 protein]
CTD PMID:25455453, PMID:29933105 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO acacetin results in increased expression of UGT1A1 mRNA CTD PMID:31621310 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
afzelin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mitf melanocyte inducing transcription factor increases expression ISO afzelin results in increased expression of MITF mRNA; afzelin results in increased expression of MITF protein CTD PMID:27287415 NCBI chr 4:130,172,484...130,425,496
Ensembl chr 4:130,172,727...130,425,532
JBrowse link
G Tyr tyrosinase multiple interactions
increases expression
ISO afzelin results in increased expression of and results in increased activity of TYR protein
afzelin results in increased expression of TYR mRNA
CTD PMID:27287415 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
G Tyrp1 tyrosinase-related protein 1 increases expression ISO afzelin results in increased expression of TYRP1 mRNA; afzelin results in increased expression of TYRP1 protein CTD PMID:27287415 NCBI chr 5:98,387,291...98,406,083
Ensembl chr 5:98,387,291...98,406,083
JBrowse link
apigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin multiple interactions EXP Apigenin inhibits the reaction [Cadmium Chloride results in increased expression of A2M protein] CTD PMID:15618353 NCBI chr 4:154,309,426...154,359,138
Ensembl chr 4:154,309,426...154,359,137
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity
multiple interactions
ISO Apigenin results in decreased activity of ABCC1 protein
[Glutathione co-treated with Apigenin] affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; Apigenin inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]; Apigenin promotes the reaction [ABCC1 protein results in increased uptake of Glutathione]; Glutathione promotes the reaction [Apigenin inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]]
CTD PMID:11306701, PMID:12485947, PMID:15670588 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Ache acetylcholinesterase multiple interactions EXP Apigenin inhibits the reaction [Rotenone results in increased activity of ACHE protein] CTD PMID:28389404 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Afg3l2 AFG3 like matrix AAA peptidase subunit 2 increases expression ISO Apigenin results in increased expression of AFG3L2 mRNA CTD PMID:22359648 NCBI chr18:63,141,418...63,185,510
Ensembl chr18:63,141,418...63,185,510
JBrowse link
G Afp alpha-fetoprotein affects binding EXP Apigenin binds to AFP protein CTD PMID:23013281, PMID:25349334 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Apigenin binds to and results in increased activity of AHR protein; Apigenin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [AHR protein binds to AIP protein]]; Apigenin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]; Apigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; Apigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein]
Apigenin binds to and results in decreased activity of AHR protein; Apigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AHR protein]
CTD PMID:14644660, PMID:17869316, PMID:20450880, PMID:29584932 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Aip aryl-hydrocarbon receptor-interacting protein multiple interactions ISO Apigenin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [AHR protein binds to AIP protein]] CTD PMID:20450880 NCBI chr 1:219,361,859...219,373,924
Ensembl chr 1:219,361,860...219,374,014
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases expression
ISO [Apigenin co-treated with Fluorouracil] results in decreased expression of AKT1 protein
Apigenin results in decreased expression of AKT1 protein
CTD PMID:15947208, PMID:19885610 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO
EXP
[polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased expression of APAF1 protein
Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of APAF1 mRNA]
CTD PMID:24070738, PMID:30107153 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Arhgap29 Rho GTPase activating protein 29 increases expression ISO Apigenin results in increased expression of ARHGAP29 mRNA CTD PMID:22359648 NCBI chr 2:225,552,075...225,613,349
Ensembl chr 2:225,552,148...225,613,359
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO Apigenin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]
Apigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein]
CTD PMID:20450880 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO Apigenin inhibits the reaction [Brefeldin A results in increased cleavage of ATF6 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased cleavage of ATF6 protein] CTD PMID:20493918 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Atg7 autophagy related 7 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Apigenin results in increased expression of ATG7 protein]; Glutathione inhibits the reaction [Apigenin results in increased expression of ATG7 protein] CTD PMID:29247770 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G B3galt5 Beta-1,3-galactosyltransferase 5 increases expression ISO Apigenin results in increased expression of B3GALT5 protein CTD PMID:22906706 NCBI chr11:36,638,067...36,683,915
Ensembl chr11:36,634,662...36,683,672
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
multiple interactions
EXP
ISO
Apigenin results in decreased expression of BAX protein
(2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of BAX protein]]; [Apigenin co-treated with Oxygen deficiency] results in increased expression of BAX protein; Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of BAX mRNA]; Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of BAX protein]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of BAX protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of BAX protein]; HIF1A protein inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of BAX protein]]
[polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased expression of BAX mRNA; [polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased expression of BAX protein
CTD PMID:24070738, PMID:24144774, PMID:25557508, PMID:30107153, PMID:30152906, PMID:31930969 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
decreases response to substance
ISO
EXP
Apigenin results in decreased expression of BCL2 protein
(2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 protein]]; Apigenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of BCL2 mRNA]; Apigenin inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; Apigenin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 protein]; HIF1A protein inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 protein]]
[Polylactic Acid-Polyglycolic Acid Copolymer co-treated with Apigenin] results in decreased expression of BCL2 mRNA; [Polylactic Acid-Polyglycolic Acid Copolymer co-treated with Apigenin] results in decreased expression of BCL2 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in decreased expression of BCL2 protein
BCL2 protein results in decreased susceptibility to Apigenin
CTD PMID:15486995, PMID:24070738, PMID:25557508, PMID:29247770, PMID:30107153, PMID:30152906, PMID:31930969 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions
EXP Apigenin results in decreased expression of BCL2L1 protein
Apigenin inhibits the reaction [Isoproterenol results in decreased expression of BCL2L1 protein]
CTD PMID:24144774, PMID:30152906 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP Apigenin inhibits the reaction [Rotenone results in decreased expression of BDNF mRNA] CTD PMID:28389404 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression
ISO Apigenin promotes the reaction [Fluorouracil results in increased expression of BECN1 protein]; Fluorouracil promotes the reaction [Apigenin results in increased expression of BECN1 protein] CTD PMID:28025107 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Bid BH3 interacting domain death agonist increases expression EXP Apigenin results in increased expression of BID protein CTD PMID:24144774 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO [TNFSF10 protein results in increased susceptibility to Apigenin] which results in decreased expression of BIRC2 protein CTD PMID:29247770 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases cleavage
multiple interactions
ISO Apigenin results in increased cleavage of BIRC3 protein
[TNFSF10 protein results in increased susceptibility to Apigenin] which results in decreased expression of BIRC3 protein
CTD PMID:15486995, PMID:29247770 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases expression ISO Apigenin results in increased expression of BNIP3L mRNA CTD PMID:22359648 NCBI chr15:43,643,897...43,667,123
Ensembl chr15:43,643,897...43,667,029
JBrowse link
G Casp1 caspase 1 multiple interactions ISO Apigenin inhibits the reaction [Uric Acid results in increased expression of and results in increased cleavage of and results in increased secretion of CASP1 protein modified form] CTD PMID:29960001 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp12 caspase 12 multiple interactions ISO Apigenin inhibits the reaction [Brefeldin A results in increased activity of CASP12 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased activity of CASP12 protein] CTD PMID:20493918 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage
ISO
EXP
[polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased expression of CASP3 mRNA; [polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased expression of CASP3 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of CASP3 protein; Apigenin promotes the reaction [Fluorouracil results in increased activity of CASP3 protein]
Apigenin results in increased activity of CASP3 protein
Apigenin results in increased cleavage of CASP3 protein
(2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP3 protein modified form]; [Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP3 protein modified form; Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of CASP3 protein]; Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of CASP3 mRNA]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]; Apigenin promotes the reaction [hydroxygenkwanin results in increased activity of CASP3 protein]; HIF1A protein inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP3 protein modified form]; hydroxygenkwanin promotes the reaction [Apigenin results in increased activity of CASP3 protein]
Apigenin inhibits the reaction [Brefeldin A results in increased activity of CASP3 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; Apigenin promotes the reaction [Fluorouracil results in increased activity of CASP3 protein]; Fluorouracil promotes the reaction [Apigenin results in increased activity of CASP3 protein]
CTD PMID:15486995, PMID:17132221, PMID:19397994, PMID:19647729, PMID:19885610, PMID:20493918, PMID:24070738, PMID:24144774, PMID:24148603, PMID:25557508, PMID:28025107, PMID:29247770, PMID:30107153, PMID:30152906, PMID:31930969 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases cleavage
increases activity
ISO Apigenin results in increased cleavage of CASP7 protein
Apigenin results in increased activity of CASP7 protein
CTD PMID:15486995, PMID:19647729 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 increases cleavage
multiple interactions
increases activity
ISO
EXP
Apigenin results in increased cleavage of CASP8 protein
[TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of CASP8 protein
Apigenin results in increased activity of CASP8 protein
Apigenin inhibits the reaction [Isoproterenol results in increased expression of CASP8 protein]; Apigenin promotes the reaction [hydroxygenkwanin results in increased activity of CASP8 protein]; hydroxygenkwanin promotes the reaction [Apigenin results in increased activity of CASP8 protein]
CTD PMID:15486995, PMID:24144774, PMID:29247770, PMID:30152906 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases cleavage
increases activity
multiple interactions
ISO
EXP
Apigenin results in increased cleavage of CASP9 protein
Apigenin results in increased activity of CASP9 protein
Apigenin promotes the reaction [Fluorouracil results in increased activity of CASP9 protein]; Fluorouracil promotes the reaction [Apigenin results in increased activity of CASP9 protein]
(2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP9 protein modified form]; [Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP9 protein modified form; Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased cleavage of CASP9 protein]; Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of CASP9 mRNA]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of CASP9 protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP9 protein]; HIF1A protein inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP9 protein modified form]
[Polylactic Acid-Polyglycolic Acid Copolymer co-treated with Apigenin] results in increased expression of CASP9 mRNA; [Polylactic Acid-Polyglycolic Acid Copolymer co-treated with Apigenin] results in increased expression of CASP9 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of CASP9 protein
CTD PMID:15486995, PMID:19397994, PMID:24070738, PMID:25557508, PMID:28025107, PMID:29247770, PMID:30107153, PMID:30152906, PMID:31930969 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase decreases expression
multiple interactions
increases activity
increases expression
decreases response to substance
ISO
EXP
Apigenin results in decreased expression of CAT mRNA
Apigenin inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Apigenin inhibits the reaction [Rotenone results in decreased activity of CAT protein]
Apigenin results in increased activity of CAT protein
Apigenin results in increased expression of CAT mRNA
CAT protein results in decreased susceptibility to Apigenin
CTD PMID:21756884, PMID:22359648, PMID:28389404, PMID:30152906 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Apigenin inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein] CTD PMID:24134915 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccn5 cellular communication network factor 5 increases expression
multiple interactions
ISO Apigenin results in increased expression of CCN5 mRNA
ESR1 protein inhibits the reaction [Apigenin results in increased expression of CCN5 mRNA]
CTD PMID:23384675 NCBI chr 3:160,207,969...160,219,316
Ensembl chr 3:160,207,913...160,219,331
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Apigenin results in decreased expression of CCNB1 mRNA; Apigenin results in decreased expression of CCNB1 protein CTD PMID:19397994, PMID:26961604 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cd40 CD40 molecule multiple interactions ISO Apigenin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD40 protein] CTD PMID:16601352 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO Apigenin results in decreased expression of CDC25C protein CTD PMID:26961604 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions
decreases expression
ISO Apigenin results in increased phosphorylation of and results in decreased activity of CDK1 protein
Apigenin results in decreased expression of CDK1 protein
CTD PMID:11322924, PMID:26872304 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdkal1 CDK5 regulatory subunit associated protein 1-like 1 increases expression ISO Apigenin results in increased expression of CDKAL1 mRNA CTD PMID:22359648 NCBI chr17:36,451,031...37,157,882
Ensembl chr17:36,451,058...37,295,069
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO Apigenin promotes the reaction [CDKN1A protein binds to PCNA protein]; TP53 protein affects the reaction [Apigenin results in increased expression of CDKN1A protein]
Apigenin results in increased expression of CDKN1A mRNA; Apigenin results in increased expression of CDKN1A protein
CTD PMID:11790449, PMID:16023288, PMID:19397994, PMID:26872304 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C increases expression ISO Apigenin results in increased expression of CDKN2C mRNA CTD PMID:18331776 NCBI chr 5:129,347,731...129,352,886
Ensembl chr 5:129,347,732...129,352,886
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta decreases expression ISO Apigenin results in decreased expression of CEBPB mRNA CTD PMID:18359623 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cftr CF transmembrane conductance regulator increases activity
affects localization
ISO Apigenin results in increased activity of CFTR protein; Apigenin results in increased activity of CFTR protein mutant form
Apigenin affects the localization of CFTR protein mutant form
CTD PMID:15191910, PMID:15277574 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP Apigenin inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of CHUK protein] CTD PMID:25935278 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of CKM protein] CTD PMID:25557508 NCBI chr 1:80,321,507...80,331,841
Ensembl chr 1:80,321,585...80,331,841
JBrowse link
G Clca1 chloride channel accessory 1 decreases expression ISO Apigenin results in decreased expression of CLCA1 mRNA CTD PMID:22359648 NCBI chr 2:250,897,980...250,923,711
Ensembl chr 2:250,897,969...250,923,744
JBrowse link
G Cox17 cytochrome c oxidase copper chaperone COX17 multiple interactions EXP Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of COX17 mRNA]; Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of COX17 protein] CTD PMID:30107153 NCBI chr11:64,962,663...64,968,437
Ensembl chr11:64,962,666...64,968,437
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression
multiple interactions
ISO Apigenin results in increased expression of CXCL12 mRNA
ESR1 protein inhibits the reaction [Apigenin results in increased expression of CXCL12 mRNA]
CTD PMID:23384675, PMID:28396216 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cycs cytochrome c, somatic affects localization
multiple interactions
ISO
EXP
Apigenin affects the localization of CYCS protein
(2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CYCS protein]; [Apigenin co-treated with Oxygen deficiency] results in increased expression of CYCS protein; Apigenin inhibits the reaction [Isoproterenol results in increased expression of CYCS protein]; HIF1A protein inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CYCS protein]
[polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] affects the localization of CYCS protein
CTD PMID:15486995, PMID:24070738, PMID:30152906, PMID:31930969 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 decreases expression ISO Apigenin results in decreased expression of CYP11B1 mRNA CTD PMID:22172629 NCBI chr 7:116,248,759...116,255,205
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions ISO Apigenin inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA] CTD PMID:23370353 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity
decreases expression
ISO Apigenin results in decreased activity of CYP19A1 protein
Apigenin results in decreased expression of CYP19A1 mRNA
CTD PMID:10403137, PMID:15319488, PMID:16023337, PMID:16965912 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases expression
ISO Apigenin binds to and results in decreased activity of CYP1A1 protein; Apigenin inhibits the reaction [CYP1A1 results in increased activity of Benzo(a)pyrene]; Apigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Apigenin results in decreased activity of CYP1A1 protein
Apigenin results in increased expression of CYP1A1 mRNA
Apigenin affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Apigenin promotes the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]
CTD PMID:11454723, PMID:11752233, PMID:16271822, PMID:17012224, PMID:17090139, PMID:20930378, PMID:21053930, PMID:21482471, PMID:26657896, PMID:31621310 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Apigenin results in decreased activity of CYP1A2 protein CTD PMID:20806393, PMID:21053930, PMID:29753067 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity
increases expression
multiple interactions
increases chemical synthesis
ISO Apigenin results in decreased activity of CYP1B1 protein
Apigenin results in increased expression of CYP1B1 mRNA
Apigenin affects the reaction [beta-Naphthoflavone results in increased expression of CYP1B1 mRNA]
CYP1B1 protein results in increased chemical synthesis of Apigenin
[CYP1B1 protein results in increased metabolism of genkwanin] which results in increased chemical synthesis of Apigenin; Apigenin binds to and results in decreased activity of CYP1B1 protein
CTD PMID:16271822, PMID:19666078, PMID:20930378, PMID:21053930, PMID:21482471, PMID:31621310 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity
ISO Apigenin inhibits the reaction [Alcohols results in increased expression of CYP2E1 protein]
Apigenin results in decreased activity of CYP2E1 protein
CTD PMID:28803762, PMID:29753067 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Apigenin inhibits the reaction [Brefeldin A results in increased expression of DDIT3 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein] CTD PMID:20493918 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 multiple interactions ISO Apigenin inhibits the reaction [Alcohols results in increased expression of DGAT1 protein] CTD PMID:28803762 NCBI chr 7:117,566,363...117,576,735
Ensembl chr 7:117,566,368...117,576,737
JBrowse link
G Dhrs11 dehydrogenase/reductase 11 decreases activity ISO Apigenin results in decreased activity of DHRS11 protein CTD PMID:30926317 NCBI chr10:72,144,042...72,153,496
Ensembl chr10:72,144,042...72,153,375
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP Apigenin inhibits the reaction [Rotenone results in decreased expression of DRD2 protein] CTD PMID:28389404 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Duox1 dual oxidase 1 decreases expression ISO Apigenin results in decreased expression of DUOX1 mRNA CTD PMID:22359648 NCBI chr 3:114,251,794...114,286,827
Ensembl chr 3:114,253,637...114,286,802
JBrowse link
G Eif5b eukaryotic translation initiation factor 5B increases expression ISO Apigenin results in increased expression of EIF5B mRNA CTD PMID:22359648 NCBI chr 9:44,658,724...44,713,518
Ensembl chr 9:44,681,494...44,713,199
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO Apigenin inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:20153296 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions ISO [Apigenin co-treated with Fluorouracil] results in decreased expression of ERBB2 protein CTD PMID:19885610 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO Apigenin inhibits the reaction [Brefeldin A results in increased phosphorylation of ERN1 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased phosphorylation of ERN1 protein] CTD PMID:20493918 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Erp29 endoplasmic reticulum protein 29 increases expression ISO Apigenin results in increased expression of ERP29 mRNA CTD PMID:22359648 NCBI chr12:40,619,377...40,625,884
Ensembl chr12:40,619,377...40,625,883
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases phosphorylation
increases activity
decreases expression
affects binding
ISO
EXP
Apigenin binds to and results in increased activity of ESR1 protein; Apigenin inhibits the reaction [Estradiol binds to ESR1 protein]; ESR1 protein inhibits the reaction [Apigenin results in increased expression of CCN5 mRNA]; ESR1 protein inhibits the reaction [Apigenin results in increased expression of CXCL12 mRNA]
Apigenin results in increased phosphorylation of ESR1 protein
Apigenin results in increased activity of ESR1 protein
Apigenin results in decreased expression of ESR1 protein
Apigenin binds to ESR1 protein
CTD PMID:14579009, PMID:16118406, PMID:16541309, PMID:16860978, PMID:17323972, PMID:23384675, PMID:28396216, PMID:29162470 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding
increases activity
ISO Apigenin binds to and results in increased activity of ESR2 protein; Apigenin inhibits the reaction [Estradiol binds to ESR2 protein]
Apigenin binds to ESR2 protein
Apigenin results in increased activity of ESR2 protein
CTD PMID:9751507, PMID:12224631, PMID:16118406, PMID:16860978, PMID:17132221 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G F2 coagulation factor II multiple interactions ISO Apigenin inhibits the reaction [F2 protein results in increased localization of Calcium] CTD PMID:19814731 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G Fas Fas cell surface death receptor decreases expression
multiple interactions
ISO
EXP
Apigenin results in decreased expression of FAS mRNA
Apigenin inhibits the reaction [Isoproterenol results in increased expression of FAS protein]
CTD PMID:18359623, PMID:30152906 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO Apigenin inhibits the reaction [Alcohols results in increased expression of FASN protein] CTD PMID:28803762 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fbp1 fructose-bisphosphatase 1 decreases expression ISO Apigenin results in decreased expression of FBP1 mRNA CTD PMID:18331776 NCBI chr17:396,175...417,480
Ensembl chr17:396,180...417,480
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO Apigenin inhibits the reaction [Sodium Chloride results in increased expression of FGF2 mRNA] CTD PMID:26800359 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fn1 fibronectin 1 increases expression ISO Apigenin results in increased expression of FN1 protein CTD PMID:26408079 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Apigenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of FOS protein]; Apigenin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; Apigenin inhibits the reaction [TNF protein results in increased expression of FOS mRNA] CTD PMID:15322261, PMID:22634262 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Frmd4a FERM domain containing 4A increases expression ISO Apigenin results in increased expression of FRMD4A mRNA CTD PMID:22359648 NCBI chr17:77,642,302...77,918,210 JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO
EXP
Apigenin results in increased expression of GCLC mRNA
[Apigenin results in increased expression of GCLC mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide
Apigenin results in increased expression of GCLC mRNA; Apigenin results in increased expression of GCLC protein
CTD PMID:11864778, PMID:22864849 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression
multiple interactions
EXP Apigenin results in increased expression of GCLM mRNA; Apigenin results in increased expression of GCLM protein
[Apigenin results in increased expression of GCLM mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide
CTD PMID:22864849 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions EXP Apigenin inhibits the reaction [Rotenone results in decreased expression of GDNF mRNA] CTD PMID:28389404 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
JBrowse link
G Gli1 GLI family zinc finger 1 decreases expression ISO Apigenin results in decreased expression of GLI1 mRNA; Apigenin results in decreased expression of GLI1 protein CTD PMID:20395211 NCBI chr 7:70,620,794...70,633,171
Ensembl chr 7:70,620,766...70,630,338
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO Apigenin results in increased expression of GPX1 mRNA CTD PMID:22359648 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP
ISO
Apigenin inhibits the reaction [Rotenone results in decreased activity of GSR protein]
Apigenin inhibits the reaction [Alcohols results in decreased expression of GSR protein]
CTD PMID:28389404, PMID:28803762 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hbegf heparin-binding EGF-like growth factor multiple interactions ISO Apigenin inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA] CTD PMID:26800359 NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression
multiple interactions
decreases activity
ISO
EXP
Apigenin results in decreased expression of HIF1A protein
Apigenin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; HIF1A protein inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP3 protein modified form]; HIF1A protein inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP9 protein modified form]; HIF1A protein inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CYCS protein]; HIF1A protein inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of BAX protein]]; HIF1A protein inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of KCNA5 protein]]; HIF1A protein inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 protein]]
Apigenin results in decreased activity of HIF1A protein
Apigenin inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]; Apigenin inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]
CTD PMID:15947208, PMID:19958256, PMID:20153296, PMID:31930969 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
decreases expression
ISO
EXP
Apigenin inhibits the reaction [Hemin results in increased activity of HMOX1 protein]; Apigenin inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; Apigenin inhibits the reaction [Hemin results in increased expression of HMOX1 protein]
[Apigenin results in increased expression of HMOX1 mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide
Apigenin results in increased expression of HMOX1 mRNA; Apigenin results in increased expression of HMOX1 protein
Apigenin results in decreased expression of HMOX1 protein
CTD PMID:16109301, PMID:22864849 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 multiple interactions ISO Apigenin inhibits the reaction [Colforsin results in increased expression of HSD3B2 mRNA] CTD PMID:23370353 NCBI chr 2:200,712,895...200,722,429
Ensembl chr 2:202,341,422...202,350,929
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 multiple interactions ISO Apigenin inhibits the reaction [Brefeldin A results in increased expression of HSP90B1 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased expression of HSP90B1 protein] CTD PMID:20493918 NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A decreases expression ISO Apigenin results in decreased expression of HSPA1A mRNA CTD PMID:22359648 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B affects expression ISO Apigenin affects the expression of HSPA1B mRNA CTD PMID:22359648 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like decreases expression ISO Apigenin results in decreased expression of HSPA1L mRNA CTD PMID:22359648 NCBI chr20:4,879,998...4,965,191
Ensembl chr20:4,959,294...4,964,963
JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 decreases expression ISO Apigenin results in decreased expression of HSPA2 mRNA CTD PMID:22359648 NCBI chr 6:99,433,575...99,436,288
Ensembl chr 6:99,433,550...99,436,289
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
decreases expression
ISO Apigenin inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]
Apigenin results in decreased expression of HSPA5 mRNA
CTD PMID:20493918, PMID:22359648 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 decreases expression ISO Apigenin results in decreased expression of HSPA8 mRNA; Apigenin results in decreased expression of HSPA8 protein CTD PMID:22359648 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Apigenin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:15113938, PMID:15322261, PMID:16987811 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha decreases expression ISO Apigenin results in decreased expression of IDH3A mRNA CTD PMID:22359648 NCBI chr 8:59,164,601...59,183,899
Ensembl chr 8:59,164,572...59,183,908
JBrowse link
G Ifng interferon gamma multiple interactions EXP Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of NFKB1 protein]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of RELA protein]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in decreased secretion of INS1 protein]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased degradation of NFKBIA protein]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein] CTD PMID:18090225 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO
EXP
Apigenin inhibits the reaction [TNF protein results in increased expression of IKBKB protein]; Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of IKBKB protein]; Apigenin results in decreased expression of and results in decreased activity of IKBKB protein; Apigenin results in decreased phosphorylation of and results in decreased activity of IKBKB protein
Apigenin inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of IKBKB protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]
CTD PMID:24148603, PMID:25557508, PMID:25935278 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA]
Apigenin inhibits the reaction [nickel chloride results in increased expression of IL10 protein]
CTD PMID:16934226, PMID:30016632 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
Apigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]
Apigenin inhibits the reaction [Adenosine Triphosphate results in increased cleavage of and results in increased secretion of IL1B protein]; Apigenin inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; Apigenin inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]; Apigenin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]; Apigenin inhibits the reaction [Poly dA-dT results in increased cleavage of and results in increased secretion of IL1B protein]; Apigenin inhibits the reaction [Uric Acid results in increased expression of and results in increased cleavage of and results in increased secretion of IL1B protein]; Apigenin promotes the reaction [Antigens, Bacterial results in increased cleavage of and results in increased secretion of IL1B protein]
Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of NFKB1 protein]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of RELA protein]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in decreased secretion of INS1 protein]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased degradation of NFKBIA protein]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Apigenin inhibits the reaction [Freund's Adjuvant results in increased expression of IL1B protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
CTD PMID:15985724, PMID:18090225, PMID:24134915, PMID:25557508, PMID:25935278, PMID:29960001, PMID:30016632 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il4 interleukin 4 decreases expression ISO Apigenin results in decreased expression of IL4 protein CTD PMID:16343431 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO
Apigenin inhibits the reaction [Freund's Adjuvant results in increased expression of IL6 protein]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Apigenin inhibits the reaction [Rotenone results in increased expression of IL6 mRNA]
Apigenin inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]; Apigenin inhibits the reaction [nickel chloride results in increased expression of IL6 protein]
CTD PMID:24134915, PMID:25557508, PMID:25935278, PMID:28389404, PMID:30016632, PMID:30152906 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Apigenin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; Apigenin inhibits the reaction [TNF protein results in increased expression of JUN mRNA] CTD PMID:15322261 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 multiple interactions EXP (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of KCNA5 protein]]; Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of KCNA5 protein]; HIF1A protein inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of KCNA5 protein]] CTD PMID:31930969 NCBI chr 4:159,077,195...159,079,003
Ensembl chr 4:159,077,195...159,079,003
JBrowse link
G Kdm3a lysine demethylase 3A increases expression ISO Apigenin results in increased expression of KDM3A mRNA CTD PMID:22359648 NCBI chr 4:99,503,160...99,547,315
Ensembl chr 4:99,503,176...99,546,905
JBrowse link
G Lamb2 laminin subunit beta 2 increases expression ISO Apigenin results in increased expression of LAMB2 protein CTD PMID:26408079 NCBI chr 8:117,268,335...117,280,517
Ensembl chr 8:117,268,337...117,280,517
JBrowse link
G Lep leptin increases expression ISO Apigenin results in increased expression of LEP mRNA; Apigenin results in increased expression of LEP protein CTD PMID:18359623 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lmbr1l limb development membrane protein 1-like increases expression ISO Apigenin results in increased expression of LMBR1L mRNA CTD PMID:22359648 NCBI chr 7:140,585,512...140,600,797
Ensembl chr 7:140,585,832...140,600,818
JBrowse link
G Lrrc26 leucine rich repeat containing 26 increases expression ISO Apigenin results in increased expression of LRRC26 mRNA CTD PMID:22359648 NCBI chr 3:2,506,426...2,507,752
Ensembl chr 3:2,506,426...2,507,752
JBrowse link
G Ltbp1 latent transforming growth factor beta binding protein 1 decreases expression ISO Apigenin results in decreased expression of LTBP1 mRNA CTD PMID:22359648 NCBI chr 6:21,203,502...21,600,441
Ensembl chr 6:21,203,502...21,600,451
JBrowse link
G Ltf lactotransferrin increases expression EXP Apigenin results in increased expression of LTF protein CTD PMID:24487097 NCBI chr 8:119,290,416...119,313,261
Ensembl chr 8:119,290,416...119,313,261
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Apigenin results in increased expression of MAP1LC3B protein modified form]; Glutathione inhibits the reaction [Apigenin results in increased expression of MAP1LC3B protein modified form] CTD PMID:29247770 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
increases activity
ISO
EXP
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[Apigenin results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [Apigenin results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; Apigenin inhibits the reaction [TNF protein results in increased activity of MAPK1 protein]; Apigenin results in increased phosphorylation of and results in increased activity of MAPK1 protein
Apigenin results in decreased phosphorylation of MAPK1 protein
Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
Apigenin results in increased activity of MAPK1 protein
CTD PMID:15322261, PMID:19647729, PMID:22864849, PMID:25557508, PMID:27468969 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO
EXP
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[Apigenin results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [Apigenin results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; Apigenin results in increased phosphorylation of and results in increased activity of MAPK3 protein
Apigenin results in decreased phosphorylation of MAPK3 protein
Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
CTD PMID:19647729, PMID:25557508, PMID:27468969 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein] CTD PMID:25557508 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein] CTD PMID:25557508 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression
multiple interactions
ISO Apigenin results in decreased expression of MCL1 mRNA
Apigenin promotes the reaction [Fluorouracil results in decreased expression of MCL1 mRNA]; Fluorouracil promotes the reaction [Apigenin results in decreased expression of MCL1 mRNA]
CTD PMID:28025107 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases phosphorylation ISO Apigenin results in decreased phosphorylation of MET protein CTD PMID:27468969 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Mib1 MIB E3 ubiquitin protein ligase 1 increases expression ISO Apigenin results in increased expression of MIB1 mRNA CTD PMID:22359648 NCBI chr18:1,970,914...2,094,920
Ensembl chr18:1,970,914...2,094,920
JBrowse link
G Mmp1 matrix metallopeptidase 1 decreases expression ISO Apigenin results in decreased expression of MMP1 mRNA; Apigenin results in decreased expression of MMP1 protein CTD PMID:21112745 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Apigenin results in decreased expression of and results in decreased activity of MMP2 protein CTD PMID:26408079 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Apigenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]; Apigenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA] CTD PMID:22634262 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mt-atp6 mitochondrially encoded ATP synthase membrane subunit 6 multiple interactions EXP Apigenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of ATP6 mRNA]; Apigenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of ATP6 protein] CTD PMID:30107153 NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599
JBrowse link
G Mt-atp8 mitochondrially encoded ATP synthase membrane subunit 8 multiple interactions EXP Apigenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of ATP8 mRNA]; Apigenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of ATP8 protein] CTD PMID:30107153 NCBI chr MT:7,758...7,961
Ensembl chr MT:7,758...7,961
JBrowse link
G Nanog Nanog homeobox decreases expression ISO Apigenin results in decreased expression of NANOG protein CTD PMID:27468969 NCBI chr 4:155,531,906...155,539,268
Ensembl chr 4:155,531,906...155,539,268
JBrowse link
G Ndufa4 NDUFA4, mitochondrial complex associated multiple interactions EXP Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of NDUFA4 mRNA] CTD PMID:30107153 NCBI chr 4:38,233,680...38,240,848
Ensembl chr 4:38,233,680...38,240,848
JBrowse link
G Neo1 neogenin 1 increases expression ISO Apigenin results in increased expression of NEO1 mRNA CTD PMID:22359648 NCBI chr 8:63,649,871...63,756,394
Ensembl chr 8:63,653,266...63,750,531
JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 multiple interactions ISO Apigenin inhibits the reaction [Sodium Chloride results in increased expression of NFAT5 mRNA] CTD PMID:26800359 NCBI chr19:38,446,059...38,533,735
Ensembl chr19:38,446,059...38,533,735
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP Apigenin affects the localization of and results in increased activity of NFE2L2 protein CTD PMID:22864849 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
affects localization
EXP
ISO
Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of NFKB1 protein]; Apigenin inhibits the reaction [Rotenone results in increased expression of NFKB1 mRNA]
Apigenin affects the localization of NFKB1 protein
Apigenin inhibits the reaction [TNF protein affects the localization of NFKB1 protein]
CTD PMID:18090225, PMID:24148603, PMID:28389404 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions EXP Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of NFKB2 protein] CTD PMID:25557508 NCBI chr 1:266,050,634...266,059,277
Ensembl chr 1:266,053,002...266,059,256
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
affects degradation
ISO
EXP
Apigenin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of [NFKBIB protein binds to NFKBIA protein]]; Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
Apigenin affects the degradation of NFKBIA protein
Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased degradation of NFKBIA protein]; Apigenin inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of NFKBIA protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in decreased expression of NFKBIA protein]
Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]
CTD PMID:15322261, PMID:16934226, PMID:18090225, PMID:24148603, PMID:25557508, PMID:25935278 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nfkbib NFKB inhibitor beta multiple interactions ISO Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of [NFKBIB protein binds to NFKBIA protein]] CTD PMID:15322261 NCBI chr 1:86,941,073...86,948,845
Ensembl chr 1:86,941,074...86,948,845
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; PPARG protein affects the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]
Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of NOS2 protein]; Apigenin inhibits the reaction [Rotenone results in increased expression of NOS2 mRNA]
CTD PMID:11343698, PMID:12512693, PMID:16934226, PMID:18090225, PMID:28389404, PMID:30152906 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Apigenin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Apigenin results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G P2rx7 purinergic receptor P2X 7 multiple interactions EXP Apigenin inhibits the reaction [Freund's Adjuvant results in increased expression of P2RX7 protein] CTD PMID:25935278 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
JBrowse link
G Pank2 pantothenate kinase 2 decreases expression ISO Apigenin results in decreased expression of PANK2 mRNA CTD PMID:22359648 NCBI chr 3:123,807,911...123,841,797
Ensembl chr 3:123,807,952...123,841,797
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO Apigenin inhibits the reaction [Brefeldin A results in increased cleavage of PARP1 protein]; Apigenin inhibits the reaction [Cyclosporine results in increased cleavage of PARP1 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased cleavage of PARP1 protein]
Apigenin results in increased cleavage of PARP1 protein
[Apigenin co-treated with 3-(4-methylphenylsulfonyl)-2-propenenitrile] results in increased cleavage of PARP1 protein; [polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased cleavage of PARP1 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of PARP1 protein
CTD PMID:20493918, PMID:22155090, PMID:24070738, PMID:24148603, PMID:29247770 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Apigenin promotes the reaction [CDKN1A protein binds to PCNA protein] CTD PMID:26872304 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pgr progesterone receptor affects binding
multiple interactions
ISO Apigenin binds to PGR protein
Apigenin inhibits the reaction [Progesterone binds to PGR protein]
CTD PMID:14579009 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions ISO Apigenin inhibits the reaction [PKM protein results in increased metabolism of Phosphoenolpyruvate] CTD PMID:25388478 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Pkmyt1 protein kinase, membrane associated tyrosine/threonine 1 decreases expression ISO Apigenin results in decreased expression of PKMYT1 mRNA CTD PMID:22359648 NCBI chr10:13,061,077...13,072,277
Ensembl chr10:13,061,170...13,073,283
JBrowse link
G Polr2h RNA polymerase II, I and III subunit H increases expression ISO Apigenin results in increased expression of POLR2H mRNA CTD PMID:22359648 NCBI chr11:83,877,760...83,882,208
Ensembl chr11:83,878,006...83,882,117
JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO Apigenin results in decreased expression of POU5F1 protein CTD PMID:22906706 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO Apigenin inhibits the reaction [Alcohols results in decreased expression of PPARA protein] CTD PMID:28803762 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
decreases expression
ISO Apigenin binds to and results in increased activity of PPARG protein; PPARG protein affects the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; PPARG protein affects the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]
Apigenin results in decreased expression of PPARG mRNA
CTD PMID:11343698, PMID:18359623 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO Apigenin inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein] CTD PMID:16873680 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
JBrowse link
G Prom1 prominin 1 decreases expression ISO Apigenin results in decreased expression of PROM1 protein CTD PMID:27468969 NCBI chr14:71,532,321...71,637,400
Ensembl chr14:71,533,063...71,637,417
JBrowse link
G Prpsap1 phosphoribosyl pyrophosphate synthetase-associated protein 1 increases expression ISO Apigenin results in increased expression of PRPSAP1 mRNA CTD PMID:22359648 NCBI chr10:105,430,516...105,492,154
Ensembl chr10:105,430,520...105,452,228
JBrowse link
G Psca prostate stem cell antigen decreases expression ISO Apigenin results in decreased expression of PSCA mRNA CTD PMID:18331776 NCBI chr 7:116,090,189...116,091,955
Ensembl chr 7:116,090,189...116,091,955
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; PPARG protein affects the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]
Apigenin inhibits the reaction [Isoproterenol results in increased expression of PTGS2 protein]
Apigenin affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
CTD PMID:11343698, PMID:16552572, PMID:30152906 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta multiple interactions ISO Apigenin inhibits the reaction [Uric Acid results in increased phosphorylation of PTK2B protein] CTD PMID:29960001 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO Apigenin inhibits the reaction [Uric Acid promotes the reaction [PYCARD protein binds to PYCARD protein]] CTD PMID:29960001 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210
JBrowse link
G Ranbp10 RAN binding protein 10 increases expression ISO Apigenin results in increased expression of RANBP10 mRNA CTD PMID:22359648 NCBI chr19:37,734,662...37,795,360
Ensembl chr19:37,734,599...37,796,089
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression
multiple interactions
affects localization
ISO
EXP
Apigenin results in increased expression of RELA protein
Apigenin inhibits the reaction [Alcohols results in increased expression of RELA protein]
Apigenin affects the localization of RELA protein
Apigenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of RELA protein]; Apigenin inhibits the reaction [TNF protein affects the localization of RELA protein]
Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of RELA protein]; Apigenin inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of RELA protein]
CTD PMID:15090468, PMID:15113938, PMID:18090225, PMID:22634262, PMID:24148603, PMID:25935278, PMID:28803762 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases expression ISO Apigenin results in decreased expression of RPS6KB1 protein CTD PMID:15947208 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 multiple interactions EXP Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of S1PR1 protein] CTD PMID:25557508 NCBI chr 2:218,654,406...218,658,761
Ensembl chr 2:218,654,554...218,658,761
JBrowse link
G S1pr2 sphingosine-1-phosphate receptor 2 multiple interactions EXP Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of S1PR2 protein] CTD PMID:25557508 NCBI chr 8:21,984,914...21,995,806
Ensembl chr 8:21,984,914...21,995,806
JBrowse link
G S1pr3 sphingosine-1-phosphate receptor 3 multiple interactions EXP Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of S1PR3 protein] CTD PMID:25557508 NCBI chr17:13,799,383...13,812,877
Ensembl chr17:13,799,383...13,812,704
JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A multiple interactions EXP Apigenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of SDHA mRNA] CTD PMID:30107153 NCBI chr 1:31,545,631...31,570,601
Ensembl chr 1:31,545,631...31,570,601
JBrowse link
G Sele selectin E multiple interactions ISO Apigenin inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:15113938, PMID:16987811 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Sf3b2 splicing factor 3b, subunit 2 increases expression ISO Apigenin results in increased expression of SF3B2 mRNA CTD PMID:22359648 NCBI chr 1:220,645,685...220,665,611
Ensembl chr 1:220,645,672...220,665,603
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO Apigenin binds to SHBG protein CTD PMID:25349334 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
G Slain2 SLAIN motif family, member 2 increases expression ISO Apigenin results in increased expression of SLAIN2 mRNA CTD PMID:22359648 NCBI chr14:37,802,347...37,880,571
Ensembl chr14:37,802,365...37,871,051
JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions EXP [Apigenin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate CTD PMID:17108059 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
JBrowse link
G Slc2a3 solute carrier family 2 member 3 multiple interactions ISO [Apigenin co-treated with Oxygen deficiency] results in decreased expression of SLC2A3 mRNA CTD PMID:20153296 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO Apigenin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein] CTD PMID:18591783 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Slc5a1 solute carrier family 5 member 1 multiple interactions ISO Apigenin analog inhibits the reaction [SLC5A1 protein results in increased uptake of methylglucoside] CTD PMID:17495124 NCBI chr14:82,910,448...82,975,303
Ensembl chr14:82,909,981...82,975,263
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO Apigenin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein] CTD PMID:22394605 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Slf2 SMC5-SMC6 complex localization factor 2 decreases expression ISO Apigenin results in decreased expression of SLF2 mRNA CTD PMID:22359648 NCBI chr 1:264,670,836...264,733,465
Ensembl chr 1:264,670,841...264,733,306
JBrowse link
G Snca synuclein alpha multiple interactions EXP Apigenin inhibits the reaction [Rotenone results in increased expression of SNCA protein] CTD PMID:28389404 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression ISO Apigenin results in increased expression of SOCS3 mRNA CTD PMID:23782265 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression ISO Apigenin results in decreased expression of SOD1 mRNA; Apigenin results in decreased expression of SOD1 protein CTD PMID:22359648 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression ISO Apigenin results in decreased expression of SOX2 protein CTD PMID:27468969 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
JBrowse link
G Sphk1 sphingosine kinase 1 multiple interactions EXP Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of SPHK1 protein] CTD PMID:25557508 NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393
JBrowse link
G Sptbn1 spectrin, beta, non-erythrocytic 1 increases expression ISO Apigenin results in increased expression of SPTBN1 mRNA CTD PMID:22359648 NCBI chr14:114,517,839...114,700,199
Ensembl chr14:114,518,816...114,692,764
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Apigenin inhibits the reaction [Alcohols results in increased expression of SREBF1 protein] CTD PMID:28803762 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation
multiple interactions
ISO Apigenin results in decreased phosphorylation of STAT3 protein
Apigenin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of STAT3 protein]
CTD PMID:20153296, PMID:27468969 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation ISO SULT1A1 protein SNP results in increased sulfation of Apigenin CTD PMID:17293380 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 multiple interactions ISO Apigenin inhibits the reaction [Progesterone results in increased expression of SULT1E1 mRNA] CTD PMID:22414680 NCBI chr14:22,070,861...22,089,264
Ensembl chr14:22,072,024...22,089,248
JBrowse link
G Syk spleen associated tyrosine kinase multiple interactions ISO Apigenin inhibits the reaction [Uric Acid results in increased phosphorylation of SYK protein] CTD PMID:29960001 NCBI chr17:12,614,311...12,669,568
Ensembl chr17:12,614,311...12,669,573
JBrowse link
G Tecr trans-2,3-enoyl-CoA reductase increases expression ISO Apigenin results in increased expression of TECR mRNA CTD PMID:22359648 NCBI chr19:24,705,478...24,732,024
Ensembl chr19:24,705,481...24,732,024
JBrowse link
G Tfpt TCF3 fusion partner decreases expression ISO Apigenin results in decreased expression of TFPT mRNA CTD PMID:22359648 NCBI chr 1:64,162,525...64,172,307
Ensembl chr 1:64,162,672...64,172,470
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Apigenin inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:28389404 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO
EXP
Apigenin inhibits the reaction [nickel chloride results in increased expression of TNF protein]; Apigenin inhibits the reaction [TNF protein affects the localization of NFKB1 protein]; Apigenin inhibits the reaction [TNF protein affects the localization of RELA protein]; Apigenin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; Apigenin inhibits the reaction [TNF protein results in increased activity of MAPK1 protein]; Apigenin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Apigenin inhibits the reaction [TNF protein results in increased expression of FOS mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Apigenin inhibits the reaction [TNF protein results in increased expression of IKBKB protein]; Apigenin inhibits the reaction [TNF protein results in increased expression of JUN mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of SELE protein]; Apigenin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of [NFKBIB protein binds to NFKBIA protein]]; Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of IKBKB protein]; Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
Apigenin inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Apigenin inhibits the reaction [Rotenone results in increased expression of TNF mRNA]; Apigenin promotes the reaction [hydroxygenkwanin results in increased expression of TNF protein]; hydroxygenkwanin promotes the reaction [Apigenin results in increased expression of TNF protein]
Apigenin inhibits the reaction [Alcohols results in increased expression of TNF protein]; Apigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]
CTD PMID:15113938, PMID:15322261, PMID:15985724, PMID:16987811, PMID:24144774, PMID:24148603, PMID:25557508, PMID:25935278, PMID:28389404, PMID:28803762, PMID:30016632, PMID:30152906 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions
increases response to substance
ISO [TNFSF10 protein results in increased susceptibility to Apigenin] which results in decreased expression of BCL2 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in decreased expression of BIRC2 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in decreased expression of BIRC3 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of CASP3 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of CASP8 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of CASP9 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of PARP1 protein CTD PMID:29247770 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO TP53 protein affects the reaction [Apigenin results in increased expression of CDKN1A protein]
Apigenin results in increased expression of TP53 protein
CTD PMID:11790449, PMID:16023288 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 increases expression ISO Apigenin results in increased expression of TP53I3 mRNA; Apigenin results in increased expression of TP53I3 protein CTD PMID:19397994 NCBI chr13:75,101,759...75,145,967
Ensembl chr13:75,105,615...75,143,441
JBrowse link
G Tp63 tumor protein p63 increases expression ISO Apigenin results in increased expression of TP63 protein CTD PMID:19397994 NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501
JBrowse link
G Tp73 tumor protein p73 increases expression ISO Apigenin results in increased expression of TP73 protein CTD PMID:19397994 NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354
JBrowse link
G Tubb5 tubulin, beta 5 class I increases expression ISO Apigenin results in increased expression of TUBB5 mRNA CTD PMID:22359648 NCBI chr20:3,422,448...3,426,420
Ensembl chr20:3,422,461...3,426,371
JBrowse link
G Tyr tyrosinase increases expression ISO Apigenin results in increased expression of TYR mRNA CTD PMID:21071833 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression
increases glucuronidation
multiple interactions
ISO Apigenin results in increased expression of UGT1A1 mRNA
UGT1A1 protein results in increased glucuronidation of Apigenin
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Apigenin results in increased expression of UGT1A1 mRNA]; [sulforafan co-treated with Apigenin] results in increased expression of UGT1A1 mRNA
CTD PMID:14557274, PMID:15090468, PMID:29584932, PMID:31621310 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of Apigenin CTD PMID:14557274 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Apigenin CTD PMID:14557274 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of Apigenin CTD PMID:7574722 NCBI chr14:22,375,428...22,486,291
Ensembl chr14:22,375,955...22,534,720
JBrowse link
G Uqcrq ubiquinol-cytochrome c reductase, complex III subunit VII multiple interactions EXP Apigenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of UQCRQ mRNA] CTD PMID:30107153 NCBI chr10:38,779,132...38,782,489
Ensembl chr10:38,779,132...38,782,419
JBrowse link
G Usp48 ubiquitin specific peptidase 48 increases expression ISO Apigenin results in increased expression of USP48 mRNA CTD PMID:22359648 NCBI chr 5:155,935,102...156,002,722
Ensembl chr 5:155,934,490...156,002,721
JBrowse link
G Utrn utrophin increases expression ISO Apigenin results in increased expression of UTRN mRNA CTD PMID:22028826 NCBI chr 1:6,451,809...6,970,040
Ensembl chr 1:6,451,810...6,970,040
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Apigenin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:15113938, PMID:16987811 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions
ISO Apigenin results in decreased expression of VEGFA mRNA
Apigenin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; Apigenin inhibits the reaction [Oxygen deficiency results in increased secretion of VEGFA protein]
CTD PMID:15947208, PMID:20153296 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Zcrb1 zinc finger CCHC-type and RNA binding motif containing 1 increases expression ISO Apigenin results in increased expression of ZCRB1 mRNA CTD PMID:22359648 NCBI chr 7:134,588,902...134,602,239
Ensembl chr 7:134,588,903...134,602,239
JBrowse link
G Zfp110 zinc finger protein 110 increases expression ISO Apigenin results in increased expression of ZFP110 mRNA CTD PMID:22359648 NCBI chr 1:65,741,769...65,757,709
Ensembl chr 1:65,742,089...65,756,528
JBrowse link
baicalein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity ISO baicalein results in decreased activity of ABCC1 protein CTD PMID:15670588 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions
ISO baicalein results in decreased expression of ACTA2 protein
baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; MIR21 mRNA inhibits the reaction [baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; SPRY1 protein affects the reaction [baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]
CTD PMID:30201452 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Afp alpha-fetoprotein affects binding EXP baicalein binds to AFP protein CTD PMID:23013281, PMID:25349334 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
affects response to substance
increases activity
increases expression
ISO AHR protein affects the reaction [baicalein results in decreased phosphorylation of RB1 protein]; baicalein binds to and results in increased activity of AHR protein
AHR protein affects the susceptibility to baicalein
baicalein results in increased activity of AHR protein
baicalein results in increased expression of AHR protein
CTD PMID:14644660, PMID:17869316, PMID:22820424 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
increases phosphorylation
multiple interactions
ISO baicalein results in decreased phosphorylation of AKT1 protein
baicalein results in increased phosphorylation of AKT1 protein
Lithium Chloride inhibits the reaction [baicalein results in decreased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [baicalein results in increased phosphorylation of AKT1 protein]
CTD PMID:18025287, PMID:22820424 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type multiple interactions
decreases activity
ISO baicalein inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid]
baicalein results in decreased activity of ALOX12 protein
CTD PMID:17027136, PMID:23238474 NCBI chr10:56,851,734...56,864,049
Ensembl chr10:56,851,734...56,864,005
JBrowse link
G Alox15 arachidonate 15-lipoxygenase decreases activity ISO baicalein results in decreased activity of ALOX15 protein CTD PMID:23238474 NCBI chr10:56,953,692...56,962,145
Ensembl chr10:56,953,691...56,962,161
JBrowse link
G App amyloid beta precursor protein multiple interactions EXP baicalein inhibits the reaction [APP protein binds to APP protein] CTD PMID:17323972 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of BAX protein modified form]
baicalein results in increased expression of BAX protein
CTD PMID:20850421, PMID:21457722 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of BCL2 protein modified form] CTD PMID:20850421 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression
ISO SB 203580 inhibits the reaction [baicalein results in decreased expression of BIRC5 protein]; wortmannin promotes the reaction [baicalein results in decreased expression of BIRC5 protein] CTD PMID:18025287 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Casp3 caspase 3 multiple interactions ISO baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of CASP3 protein modified form] CTD PMID:20850421 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of CASP8 protein modified form] CTD PMID:20850421 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO baicalein results in decreased expression of CCNA2 protein CTD PMID:21457722 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO baicalein results in decreased expression of CCNB1 protein CTD PMID:18025287 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
increases expression
ISO Lithium Chloride inhibits the reaction [baicalein results in decreased expression of CCND1 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of CCND1 mRNA] CTD PMID:19160421, PMID:21457722, PMID:22820424, PMID:24560969 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO baicalein results in decreased expression of CCNE1 protein CTD PMID:24560969 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases phosphorylation
multiple interactions
ISO baicalein results in decreased phosphorylation of CDK1 protein
SB 203580 inhibits the reaction [baicalein results in decreased phosphorylation of CDK1 protein]; wortmannin promotes the reaction [baicalein results in decreased phosphorylation of CDK1 protein]
CTD PMID:18025287 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression ISO baicalein results in increased expression of CDK4 protein CTD PMID:22820424 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression ISO baicalein results in decreased expression of CEBPA protein CTD PMID:24560969 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta decreases expression ISO baicalein results in decreased expression of CEBPB mRNA CTD PMID:24560969 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cebpg CCAAT/enhancer binding protein gamma decreases expression ISO baicalein results in decreased expression of CEBPG mRNA CTD PMID:24560969 NCBI chr 1:91,286,956...91,297,459
Ensembl chr 1:91,287,917...91,296,656
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions ISO baicalein inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of CFLAR protein] CTD PMID:20850421 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Cftr CF transmembrane conductance regulator increases activity ISO baicalein results in increased activity of CFTR protein CTD PMID:15234961 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO baicalein inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein] CTD PMID:30201452 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions EXP baicalein inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA] CTD PMID:19474275 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Csf2 colony stimulating factor 2 decreases expression ISO baicalein results in decreased expression of CSF2 mRNA CTD PMID:10718847 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] affects the localization of CYCS protein] CTD PMID:20850421 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
decreases expression
multiple interactions
increases chemical synthesis
decreases activity
ISO baicalein results in increased expression of CYP1A1 protein
baicalein results in decreased expression of CYP1A1 mRNA
[CYP1A1 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein; baicalein inhibits the reaction [benz(a)anthracene results in increased expression of CYP1A1 mRNA]; baicalein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CYP1A1 protein results in increased chemical synthesis of baicalein
baicalein results in decreased activity of CYP1A1 protein
CTD PMID:12224597, PMID:14644660, PMID:18451504, PMID:19666078, PMID:21053930, PMID:21482471 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
increases chemical synthesis
multiple interactions
ISO baicalein results in decreased activity of CYP1A2 protein
CYP1A2 protein results in increased chemical synthesis of baicalein
[CYP1A2 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein
CTD PMID:19666078, PMID:21053930, PMID:29753067 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity
increases chemical synthesis
multiple interactions
ISO baicalein results in decreased activity of CYP1B1 protein
CYP1B1 protein results in increased chemical synthesis of baicalein
[CYP1B1 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein; baicalein binds to and results in decreased activity of CYP1B1 protein; baicalein inhibits the reaction [benz(a)anthracene results in increased expression of CYP1B1 mRNA]
CTD PMID:12224597, PMID:19666078, PMID:21053930, PMID:21482471 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO baicalein results in increased expression of CYP2B6 mRNA CTD PMID:25625231 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO baicalein results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO baicalein results in decreased activity of CYP2E1 protein CTD PMID:29753067 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 decreases expression ISO baicalein results in decreased expression of DGAT1 protein CTD PMID:24560969 NCBI chr 7:117,566,363...117,576,735
Ensembl chr 7:117,566,368...117,576,737
JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 increases expression ISO baicalein results in increased expression of DLK1 mRNA CTD PMID:24560969 NCBI chr 6:133,576,513...133,583,751
Ensembl chr 6:133,552,821...133,583,751
JBrowse link
G Egf epidermal growth factor multiple interactions ISO baicalein inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; baicalein inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein] CTD PMID:25625231 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO baicalein inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:25625231 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egr2 early growth response 2 decreases expression ISO baicalein results in decreased expression of EGR2 mRNA CTD PMID:24560969 NCBI chr20:22,452,170...22,461,018
Ensembl chr20:22,454,463...22,459,025
JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions ISO baicalein inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein] CTD PMID:25625231 NCBI chr  X:1,287,875...1,304,822
Ensembl chr  X:1,297,099...1,304,822
JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression ISO baicalein results in decreased expression of FABP4 protein CTD PMID:24560969 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fasn fatty acid synthase decreases expression ISO baicalein results in decreased expression of FASN protein CTD PMID:24560969 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO baicalein inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein] CTD PMID:30201452 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Gli1 GLI family zinc finger 1 decreases expression ISO baicalein results in decreased expression of GLI1 mRNA; baicalein results in decreased expression of GLI1 protein CTD PMID:20395211 NCBI chr 7:70,620,794...70,633,171
Ensembl chr 7:70,620,766...70,630,338
JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 decreases expression ISO baicalein results in decreased expression of GPAT3 protein CTD PMID:24560969 NCBI chr14:10,343,287...10,396,565
Ensembl chr14:10,343,282...10,395,047
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation ISO baicalein results in decreased phosphorylation of GSK3B protein CTD PMID:22820424 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hes1 hes family bHLH transcription factor 1 multiple interactions
increases expression
ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HES1 mRNA] CTD PMID:19160421 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248
JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 multiple interactions
increases expression
ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HEY1 mRNA] CTD PMID:19160421 NCBI chr 2:95,320,147...95,322,701
Ensembl chr 2:95,320,283...95,322,696
JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 multiple interactions
increases expression
ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HEY2 mRNA] CTD PMID:19160421 NCBI chr 1:29,191,170...29,201,257
Ensembl chr 1:29,191,192...29,201,531
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO baicalein results in increased expression of HMOX1 mRNA; baicalein results in increased expression of HMOX1 protein
Hemin promotes the reaction [baicalein results in increased expression of HMOX1 protein]; HMOX1 protein promotes the reaction [baicalein inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]
CTD PMID:14563492 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions
increases activity
ISO 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [baicalein results in increased activity of HSD11B2 protein] CTD PMID:18032417 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO baicalein inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein] CTD PMID:17458902 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of IL1B protein] CTD PMID:22369883 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Ins2 insulin 2 multiple interactions
increases secretion
ISO baicalein promotes the reaction [Glucose results in increased secretion of INS protein]
baicalein results in increased secretion of INS protein
CTD PMID:17192482 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO baicalein inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein] CTD PMID:17458902 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Klf2 Kruppel-like factor 2 increases expression ISO baicalein results in increased expression of KLF2 mRNA CTD PMID:24560969 NCBI chr16:19,223,087...19,225,037
Ensembl chr16:19,223,087...19,225,037
JBrowse link
G Klf5 Kruppel-like factor 5 decreases expression ISO baicalein results in decreased expression of KLF5 mRNA CTD PMID:24560969 NCBI chr15:83,703,796...83,722,921
Ensembl chr15:83,703,791...83,722,921
JBrowse link
G Lpin1 lipin 1 decreases expression ISO baicalein results in decreased expression of LPIN1 protein CTD PMID:24560969 NCBI chr 6:41,796,214...41,905,149
Ensembl chr 6:41,799,749...41,870,046
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO baicalein results in decreased phosphorylation of and results in decreased activity of MAPK1 protein
baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of MAPK1 protein modified form]; baicalein inhibits the reaction [PLA2G2A protein results in increased phosphorylation of MAPK1 protein]
CTD PMID:10718847, PMID:20850421, PMID:31811862 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO baicalein results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of MAPK3 protein modified form]; baicalein inhibits the reaction [PLA2G2A protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:10718847, PMID:20850421, PMID:31811862 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO baicalein results in decreased phosphorylation of and results in decreased activity of MAPK8 protein CTD PMID:10718847 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mir21 microRNA 21 multiple interactions ISO baicalein inhibits the reaction [TGFB1 protein results in increased expression of MIR21 mRNA]; MIR21 mRNA inhibits the reaction [baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]] CTD PMID:30201452 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases activity
multiple interactions
ISO baicalein results in decreased activity of MMP2 protein
baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP2 mRNA]
CTD PMID:21803068, PMID:22369883 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases activity
ISO baicalein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]
baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP9 mRNA]
baicalein results in decreased activity of MMP9 protein
CTD PMID:19804834, PMID:21803068, PMID:22369883 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO baicalein inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein] CTD PMID:27780710 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO baicalein results in decreased phosphorylation of and results in decreased activity of MTOR protein CTD PMID:24560969 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Nat1 N-acetyltransferase 1 decreases expression ISO baicalein results in decreased expression of NAT1 mRNA; baicalein results in decreased expression of NAT1 protein CTD PMID:15796204 NCBI chr16:23,970,742...23,991,573
Ensembl chr16:23,970,743...23,991,573
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases localization ISO baicalein results in decreased localization of NFKB1 protein CTD PMID:21803068 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases phosphorylation
ISO baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of NFKBIA protein]
baicalein results in decreased phosphorylation of NFKBIA protein
CTD PMID:20850421 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nfkbib NFKB inhibitor beta decreases phosphorylation ISO baicalein results in decreased phosphorylation of NFKBIB protein CTD PMID:21803068 NCBI chr 1:86,941,073...86,948,845
Ensembl chr 1:86,941,074...86,948,845
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
ISO baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of NOS2 protein]; baicalein inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Hemin promotes the reaction [baicalein inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; HMOX1 protein promotes the reaction [baicalein inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]; tin protoporphyrin IX inhibits the reaction [baicalein inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]
baicalein results in decreased expression of NOS2 protein
CTD PMID:14563492, PMID:20850421, PMID:22369883 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Notch1 notch receptor 1 increases activity
increases expression
ISO baicalein results in increased activity of NOTCH1 protein
baicalein results in increased expression of NOTCH1 mRNA
CTD PMID:19160421 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects localization ISO baicalein affects the localization of NR1I3 protein CTD PMID:25625231 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Pkm pyruvate kinase M1/2 increases activity ISO baicalein results in increased activity of PKM protein CTD PMID:25388478 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Pla2g2a phospholipase A2 group IIA multiple interactions ISO baicalein inhibits the reaction [PLA2G2A protein results in increased expression of PTGS2 protein]; baicalein inhibits the reaction [PLA2G2A protein results in increased phosphorylation of MAPK1 protein]; baicalein inhibits the reaction [PLA2G2A protein results in increased phosphorylation of MAPK3 protein] CTD PMID:31811862 NCBI chr 5:157,282,650...157,285,295
Ensembl chr 5:157,282,669...157,285,328
JBrowse link
G Plau plasminogen activator, urokinase decreases activity ISO baicalein results in decreased activity of PLAU protein CTD PMID:21803068 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions ISO baicalein inhibits the reaction [Fenretinide results in increased expression of PMAIP1 mRNA] CTD PMID:17216584 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO baicalein results in decreased expression of PPARG protein CTD PMID:24560969 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prkca protein kinase C, alpha decreases phosphorylation ISO baicalein results in decreased phosphorylation of PRKCA protein CTD PMID:21803068 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO baicalein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 mRNA]; baicalein inhibits the reaction [PLA2G2A protein results in increased expression of PTGS2 protein]
CTD PMID:19804834, PMID:22369883, PMID:31811862 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
decreases phosphorylation
ISO AHR protein affects the reaction [baicalein results in decreased phosphorylation of RB1 protein]; Lithium Chloride inhibits the reaction [baicalein results in decreased phosphorylation of RB1 protein] CTD PMID:22820424 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization
decreases localization
ISO baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] affects the localization of RELA protein]; baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein]
NKILA mRNA promotes the reaction [baicalein affects the localization of RELA protein]
baicalein results in decreased localization of RELA protein
CTD PMID:20850421, PMID:21803068, PMID:22369883, PMID:29481769 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO baicalein results in decreased phosphorylation of and results in decreased activity of RPS6KB1 protein CTD PMID:24560969 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity ISO baicalein results in decreased activity of SLC22A6 protein CTD PMID:32159797 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Snca synuclein alpha multiple interactions ISO baicalein inhibits the reaction [SNCA protein binds to SNCA protein]
baicalein inhibits the reaction [Rotenone promotes the reaction [SNCA protein binds to SNCA protein]]; baicalein inhibits the reaction [Rotenone results in increased expression of SNCA protein]
CTD PMID:27425033 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 multiple interactions ISO baicalein inhibits the reaction [TGFB1 protein results in decreased expression of SPRY1 protein]; SPRY1 protein affects the reaction [baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]] CTD PMID:30201452 NCBI chr 2:124,400,689...124,405,331
Ensembl chr 2:124,400,679...124,405,331
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression ISO baicalein results in decreased expression of SREBF1 protein CTD PMID:24560969 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO baicalein inhibits the reaction [TGFB1 protein results in increased phosphorylation of STAT3 protein] CTD PMID:30201452 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP
ISO
baicalein inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA]
baicalein inhibits the reaction [TGFB1 protein results in decreased expression of SPRY1 protein]; baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; baicalein inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; baicalein inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]; baicalein inhibits the reaction [TGFB1 protein results in increased expression of MIR21 mRNA]; baicalein inhibits the reaction [TGFB1 protein results in increased phosphorylation of STAT3 protein]; MIR21 mRNA inhibits the reaction [baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; SPRY1 protein affects the reaction [baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]
CTD PMID:19474275, PMID:30201452 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO baicalein inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:27425033 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
ISO baicalein results in decreased expression of TNF protein
baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF protein]
CTD PMID:20850421, PMID:22369883 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases expression ISO baicalein results in increased expression of TP53 protein CTD PMID:21457722 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO baicalein results in decreased expression of VEGFA protein CTD PMID:16638750 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO baicalein inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased activity of XIAP protein] CTD PMID:20850421 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
baicalin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
increases expression
EXP baicalin results in increased expression of and results in increased activity of ACHE protein
baicalin results in increased expression of ACHE mRNA
CTD PMID:27019979 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Ahr aryl hydrocarbon receptor increases activity ISO baicalin results in increased activity of AHR protein CTD PMID:17869316, PMID:26204831 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions EXP baicalin inhibits the reaction [Hydrogen Peroxide affects the localization of and results in increased activity of ALOX5 protein] CTD PMID:20139896 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions EXP baicalin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of ATF2 protein] CTD PMID:24312512 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO
EXP
baicalin results in increased expression of BAX protein
baicalin inhibits the reaction [Rotenone affects the expression of BAX protein]
CTD PMID:21457722, PMID:25423838 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP baicalin inhibits the reaction [Rotenone affects the expression of BCL2 protein] CTD PMID:25423838 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions EXP baicalin inhibits the reaction [Rotenone affects the expression of CASP3 protein] CTD PMID:25423838 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO baicalin results in decreased expression of CCNA2 protein CTD PMID:21457722 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnd1 cyclin D1 increases expression
decreases expression
multiple interactions
ISO baicalin results in increased expression of CCND1 mRNA
baicalin results in decreased expression of CCND1 protein
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of CCND1 mRNA]
CTD PMID:19160421, PMID:21457722 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions EXP baicalin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA] CTD PMID:19474275 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO 3',4'-dimethoxyflavone inhibits the reaction [baicalin results in increased expression of CYP1A1 mRNA]; 3',4'-dimethoxyflavone inhibits the reaction [baicalin results in increased expression of CYP1A1 protein]; baicalin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
baicalin results in increased expression of CYP1A1 mRNA; baicalin results in increased expression of CYP1A1 protein
CTD PMID:18451504, PMID:26204831 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression
ISO 3',4'-dimethoxyflavone inhibits the reaction [baicalin results in increased expression of CYP1A2 mRNA]; 3',4'-dimethoxyflavone inhibits the reaction [baicalin results in increased expression of CYP1A2 protein]
resveratrol inhibits the reaction [baicalin results in increased expression of CYP1A2 mRNA]; resveratrol inhibits the reaction [baicalin results in increased expression of CYP1A2 protein]
baicalin results in increased expression of CYP1A2 mRNA; baicalin results in increased expression of CYP1A2 protein
CTD PMID:26204831 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Egf epidermal growth factor multiple interactions ISO baicalin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; baicalin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein] CTD PMID:25625231 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO baicalin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:25625231 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions ISO baicalin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein] CTD PMID:25625231 NCBI chr  X:1,287,875...1,304,822
Ensembl chr  X:1,297,099...1,304,822
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO baicalin inhibits the reaction [Palmitic Acid results in increased phosphorylation of ERN1 protein] CTD PMID:29031535 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Foxa2 forkhead box A2 decreases expression ISO baicalin results in decreased expression of FOXA2 mRNA; baicalin results in decreased expression of FOXA2 protein CTD PMID:32687838 NCBI chr 3:142,383,084...142,387,493
Ensembl chr 3:142,383,278...142,387,481
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions EXP baicalin inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GOT1 protein] CTD PMID:15645217 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP baicalin inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GPT protein] CTD PMID:15645217 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Hes1 hes family bHLH transcription factor 1 increases expression
multiple interactions
ISO baicalin results in increased expression of HES1 mRNA
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HES1 mRNA]
CTD PMID:19160421 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248
JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 increases expression
multiple interactions
ISO baicalin results in increased expression of HEY1 mRNA
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HEY1 mRNA]
CTD PMID:19160421 NCBI chr 2:95,320,147...95,322,701
Ensembl chr 2:95,320,283...95,322,696
JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 multiple interactions
increases expression
ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HEY2 mRNA] CTD PMID:19160421 NCBI chr 1:29,191,170...29,201,257
Ensembl chr 1:29,191,192...29,201,531
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
baicalin promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 mRNA]; baicalin promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 protein]
baicalin results in increased expression of HMOX1 mRNA; baicalin results in increased expression of HMOX1 protein
CTD PMID:16824337, PMID:18187930 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnf1a HNF1 homeobox A multiple interactions
decreases expression
ISO baicalin inhibits the reaction [HNF4A protein binds to HNF1A promoter]; HNF1A protein promotes the reaction [baicalin results in decreased secretion of Hepatitis B Surface Antigens]; HNF4A protein promotes the reaction [baicalin results in decreased expression of HNF1A mRNA]; HNF4A protein promotes the reaction [baicalin results in decreased expression of HNF1A protein]
baicalin results in decreased expression of HNF1A mRNA; baicalin results in decreased expression of HNF1A protein
CTD PMID:32687838 NCBI chr12:47,407,811...47,433,342
Ensembl chr12:47,407,811...47,433,342
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases expression
multiple interactions
ISO baicalin results in decreased expression of HNF4A protein
baicalin inhibits the reaction [HNF4A protein binds to HNF1A promoter]; HNF4A protein promotes the reaction [baicalin results in decreased expression of HNF1A mRNA]; HNF4A protein promotes the reaction [baicalin results in decreased expression of HNF1A protein]; HNF4A protein promotes the reaction [baicalin results in decreased secretion of Hepatitis B Surface Antigens]
baicalin results in decreased expression of HNF4A mRNA; baicalin results in decreased expression of HNF4A protein
CTD PMID:32687838 NCBI chr 3:159,902,441...159,965,003
Ensembl chr 3:159,902,441...159,965,003
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO baicalin inhibits the reaction [Palmitic Acid results in increased secretion of IL1B protein] CTD PMID:29031535 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
EXP
ISO
baicalin results in decreased expression of IL6 mRNA; baicalin results in decreased expression of IL6 protein
baicalin inhibits the reaction [Palmitic Acid results in increased secretion of IL6 protein]
CTD PMID:22019745, PMID:29031535 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor decreases expression EXP baicalin results in decreased expression of MYD88 protein CTD PMID:22019745 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression EXP baicalin results in increased expression of NFKBIA protein CTD PMID:22019745 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO baicalin inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 protein] CTD PMID:29031535 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
EXP
ISO
baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; mifobate inhibits the reaction [baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]
baicalin results in decreased expression of NOS2 mRNA; baicalin results in decreased expression of NOS2 protein
baicalin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; baicalin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]
CTD PMID:18187930, PMID:22019745, PMID:24312512 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Notch1 notch receptor 1 increases activity
increases expression
ISO baicalin results in increased activity of NOTCH1 protein
baicalin results in increased expression of NOTCH1 mRNA
CTD PMID:19160421 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Pkm pyruvate kinase M1/2 increases activity ISO baicalin results in increased activity of PKM protein CTD PMID:25388478 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of and results in decreased activity of PPARG protein] CTD PMID:24312512 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prima1 proline rich membrane anchor 1 increases expression EXP baicalin results in increased expression of PRIMA1 mRNA CTD PMID:27019979 NCBI chr 6:127,075,954...127,127,985
Ensembl chr 6:127,075,954...127,127,413
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression EXP baicalin results in decreased expression of PTGS2 mRNA; baicalin results in decreased expression of PTGS2 protein CTD PMID:22019745 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP baicalin affects the localization of and results in decreased expression of RELA protein CTD PMID:22019745 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP baicalin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA] CTD PMID:19474275 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tlr4 toll-like receptor 4 decreases expression
multiple interactions
EXP baicalin results in decreased expression of TLR4 protein
baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]
CTD PMID:22019745, PMID:24312512 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
baicalin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; baicalin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
baicalin results in decreased expression of TNF mRNA; baicalin results in decreased expression of TNF protein
baicalin inhibits the reaction [Paraquat results in increased expression of TNF protein]
CTD PMID:16824337, PMID:18187930, PMID:22019745 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases expression ISO baicalin results in increased expression of TP53 protein CTD PMID:21457722 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Txnip thioredoxin interacting protein multiple interactions ISO baicalin inhibits the reaction [Palmitic Acid results in increased expression of TXNIP protein]; dorsomorphin inhibits the reaction [baicalin inhibits the reaction [Palmitic Acid results in increased expression of TXNIP protein]] CTD PMID:29031535 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
JBrowse link
cirsiliol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
increases metabolic processing
increases expression
ISO cirsiliol results in decreased activity of CYP1A1 protein
CYP1A1 protein results in increased metabolism of cirsiliol
cirsiliol results in increased expression of CYP1A1 mRNA
CTD PMID:19601638, PMID:21482471 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
increases metabolic processing
decreases activity
ISO cirsiliol results in increased expression of CYP1B1 mRNA
CYP1B1 protein results in increased metabolism of cirsiliol
cirsiliol results in decreased activity of CYP1B1 protein
CTD PMID:19601638, PMID:21482471 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
cudraflavone B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO cudraflavone B results in increased expression of BAX protein
resveratrol inhibits the reaction [cudraflavone B results in increased expression of BAX protein]; sirtinol promotes the reaction [cudraflavone B results in increased expression of BAX protein]
CTD PMID:23881456 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO resveratrol inhibits the reaction [cudraflavone B results in decreased expression of BCL2 protein]; sirtinol promotes the reaction [cudraflavone B results in decreased expression of BCL2 protein] CTD PMID:23881456 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO cudraflavone B results in increased activity of CASP3 protein
resveratrol inhibits the reaction [cudraflavone B results in increased activity of CASP3 protein]; sirtinol promotes the reaction [cudraflavone B results in increased activity of CASP3 protein]
CTD PMID:23881456 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO cudraflavone B results in increased expression of CDKN1A protein
resveratrol inhibits the reaction [cudraflavone B results in increased expression of CDKN1A protein]; sirtinol promotes the reaction [cudraflavone B results in increased expression of CDKN1A protein]
CTD PMID:23881456 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
increases expression
ISO resveratrol inhibits the reaction [cudraflavone B results in increased expression of CDKN1B protein]; sirtinol promotes the reaction [cudraflavone B results in increased expression of CDKN1B protein] CTD PMID:23881456 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity ISO cudraflavone B results in increased activity of MAPK1 protein CTD PMID:23881456 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases activity ISO cudraflavone B results in increased activity of MAPK3 protein CTD PMID:23881456 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO cudraflavone B results in increased phosphorylation of and results in increased degradation of NFKBIA protein CTD PMID:23881456 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
decreases phosphorylation
ISO resveratrol inhibits the reaction [cudraflavone B results in decreased phosphorylation of RB1 protein]; sirtinol promotes the reaction [cudraflavone B results in decreased phosphorylation of RB1 protein] CTD PMID:23881456 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization ISO cudraflavone B affects the localization of RELA protein CTD PMID:23881456 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sirt1 sirtuin 1 increases expression
multiple interactions
ISO cudraflavone B results in increased expression of SIRT1 mRNA; cudraflavone B results in increased expression of SIRT1 protein
resveratrol promotes the reaction [cudraflavone B results in increased expression of SIRT1 mRNA]; resveratrol promotes the reaction [cudraflavone B results in increased expression of SIRT1 protein]; sirtinol inhibits the reaction [cudraflavone B results in increased expression of SIRT1 mRNA]; sirtinol inhibits the reaction [cudraflavone B results in increased expression of SIRT1 protein]
CTD PMID:23881456 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO cudraflavone B results in increased expression of TP53 protein
resveratrol inhibits the reaction [cudraflavone B results in increased expression of TP53 protein]; sirtinol promotes the reaction [cudraflavone B results in increased expression of TP53 protein]
CTD PMID:23881456 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
diosmetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity ISO diosmetin results in decreased activity of ABCC1 protein CTD PMID:15670588 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO diosmetin results in decreased activity of CYP1A1 protein CTD PMID:10781868, PMID:21482471 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO diosmetin results in decreased activity of CYP1A2 protein CTD PMID:28867436 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO diosmetin results in decreased activity of CYP1B1 protein CTD PMID:10781868, PMID:21482471 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO diosmetin results in decreased activity of CYP2C19 protein CTD PMID:28867436 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO diosmetin results in decreased activity of CYP2C8 protein CTD PMID:28867436 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO diosmetin results in decreased activity of CYP2E1 protein CTD PMID:28867436 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO diosmetin inhibits the reaction [CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam] CTD PMID:18191104 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO diosmetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:16934226 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO diosmetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:16934226 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Pkm pyruvate kinase M1/2 increases activity ISO diosmetin results in increased activity of PKM protein CTD PMID:25388478 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions EXP [diosmetin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate CTD PMID:17108059 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO diosmetin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:28867436 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions ISO diosmetin inhibits the reaction [SLCO1A2 protein results in increased uptake of Rosuvastatin Calcium] CTD PMID:28867436 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO diosmetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:16934226 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
diosmin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO Diosmin binds to and results in increased activity of AHR protein CTD PMID:14644660 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions EXP Diosmin inhibits the reaction [Lipopolysaccharides results in increased expression of BAD protein] CTD PMID:21477647 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein] CTD PMID:32061149 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO
[Diosmin co-treated with Lipopolysaccharides] results in increased expression of BCL2 protein
Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2 protein]
CTD PMID:21477647, PMID:32061149 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP3 protein]; Diosmin inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP3 protein]
CTD PMID:21477647, PMID:23665045, PMID:32061149 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP7 protein] CTD PMID:23665045 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp9 caspase 9 multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP9 protein] CTD PMID:23665045 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of CAT protein]; Diosmin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein] CTD PMID:22056647, PMID:23665045 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP2E1 protein] CTD PMID:23665045 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP
ISO
Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of GSR protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of GSR protein]
CTD PMID:23665045, PMID:32061149 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of IL6 protein] CTD PMID:32061149 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of MKI67 protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MKI67 protein] CTD PMID:23665045 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NOS2 protein] CTD PMID:23665045 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of PARP1 protein] CTD PMID:32061149 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PCNA protein] CTD PMID:23665045 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO
Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PTGS2 protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein]
CTD PMID:23665045, PMID:32061149 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein] CTD PMID:32061149 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of TNF protein]; Diosmin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:21477647, PMID:23665045 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TP53 protein] CTD PMID:23665045 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP
ISO
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of XDH protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of XDH protein]
CTD PMID:23665045, PMID:32061149 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link
galangin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO galangin results in increased expression of ABCB1 mRNA CTD PMID:26238175 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity ISO galangin results in decreased activity of ABCC1 protein CTD PMID:15670588 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Ache acetylcholinesterase decreases activity EXP galangin results in decreased activity of ACHE protein CTD PMID:20452337 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Ahr aryl hydrocarbon receptor increases activity
multiple interactions
affects localization
ISO galangin results in increased activity of AHR protein
galangin affects the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; galangin binds to and results in decreased activity of AHR protein; galangin binds to and results in increased activity of AHR protein; galangin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene affects the localization of AHR protein]; galangin inhibits the reaction [Benzo(a)pyrene affects the localization of AHR protein]; galangin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of AHR protein]; galangin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; galangin inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein]
galangin affects the localization of AHR protein
CTD PMID:10953044, PMID:14644660, PMID:17090139, PMID:20435555, PMID:20450880 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO galangin results in decreased phosphorylation of AKT1 protein CTD PMID:18455702 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Atg12 autophagy related 12 increases expression
multiple interactions
ISO galangin results in increased expression of ATG12 mRNA; galangin results in increased expression of ATG12 protein
[ATG12 mutant form co-treated with galangin] results in decreased activity of CASP3 protein; LY2109761 inhibits the reaction [galangin results in increased expression of ATG12 protein]; SMAD4 mutant form inhibits the reaction [galangin results in increased expression of ATG12 protein]
CTD PMID:25268046 NCBI chr18:40,721,799...40,732,143
Ensembl chr18:40,721,800...40,732,126
JBrowse link
G Atg16l1 autophagy related 16-like 1 multiple interactions
increases expression
ISO [ATG16L1 mutant form co-treated with galangin] results in decreased activity of CASP3 protein; LY2109761 inhibits the reaction [galangin results in increased expression of ATG16L1 protein]; SMAD4 mutant form inhibits the reaction [galangin results in increased expression of ATG16L1 protein]
galangin results in increased expression of ATG16L1 mRNA; galangin results in increased expression of ATG16L1 protein
CTD PMID:25268046 NCBI chr 9:94,879,876...94,915,231
Ensembl chr 9:94,879,745...94,915,228
JBrowse link
G Atg3 autophagy related 3 multiple interactions
increases expression
ISO [ATG3 mutant form co-treated with galangin] results in decreased activity of CASP3 protein; LY2109761 inhibits the reaction [galangin results in increased expression of ATG3 protein]; SMAD4 mutant form inhibits the reaction [galangin results in increased expression of ATG3 protein]
galangin results in increased expression of ATG3 mRNA; galangin results in increased expression of ATG3 protein
CTD PMID:25268046 NCBI chr11:60,585,192...60,613,706
Ensembl chr11:60,585,171...60,613,718
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO galangin results in increased expression of BAX protein CTD PMID:25450235 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO galangin results in decreased expression of BCL2 protein CTD PMID:25450235 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO galangin results in decreased expression of BCL2L1 protein CTD PMID:25450235 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression
ISO [BECN1 mutant form co-treated with galangin] results in decreased activity of CASP3 protein; LY2109761 inhibits the reaction [galangin results in increased expression of BECN1 protein]; SMAD4 mutant form inhibits the reaction [galangin results in increased expression of BECN1 protein]
galangin results in increased expression of BECN1 mRNA; galangin results in increased expression of BECN1 protein
CTD PMID:25268046 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Casp1 caspase 1 multiple interactions ISO galangin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased activity of CASP1 protein] CTD PMID:23535185 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO [ATG12 mutant form co-treated with galangin] results in decreased activity of CASP3 protein; [ATG16L1 mutant form co-treated with galangin] results in decreased activity of CASP3 protein; [ATG3 mutant form co-treated with galangin] results in decreased activity of CASP3 protein; [BECN1 mutant form co-treated with galangin] results in decreased activity of CASP3 protein
galangin results in increased cleavage of CASP3 protein
CTD PMID:25268046, PMID:25450235 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO galangin results in decreased expression of CCND1 protein CTD PMID:25450235 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO galangin results in decreased expression of CDK4 protein CTD PMID:25450235 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO galangin results in decreased expression of CDK6 protein CTD PMID:25450235 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO galangin results in increased expression of CDKN1A protein CTD PMID:25450235 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
decreases activity
ISO galangin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; galangin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
galangin results in increased expression of CYP1A1 mRNA
galangin affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
galangin results in decreased activity of CYP1A1 protein
CTD PMID:10953044, PMID:17090139, PMID:20930378, PMID:21053930 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO galangin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]
galangin results in decreased activity of CYP1A2 protein
CTD PMID:17090139, PMID:20806393, PMID:21053930 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO galangin binds to and results in decreased activity of CYP1B1 protein CTD PMID:21053930 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO galangin results in increased expression of CYP2B6 mRNA CTD PMID:25625231 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Egf epidermal growth factor multiple interactions ISO galangin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; galangin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein] CTD PMID:25625231 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO galangin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:25625231 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions ISO galangin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein] CTD PMID:25625231 NCBI chr  X:1,287,875...1,304,822
Ensembl chr  X:1,297,099...1,304,822
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO galangin promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:20153296 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G Epas1 endothelial PAS domain protein 1 multiple interactions
increases expression
ISO ferrous sulfate inhibits the reaction [galangin results in increased expression of EPAS1 protein]; Iron inhibits the reaction [galangin results in increased expression of EPAS1 protein] CTD PMID:17973296 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
JBrowse link
G Esr1 estrogen receptor 1 increases phosphorylation EXP galangin results in increased phosphorylation of ESR1 protein CTD PMID:17323972 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Glo1 glyoxalase 1 multiple interactions ISO galangin results in decreased expression of and results in decreased activity of GLO1 protein CTD PMID:29113808 NCBI chr20:9,273,589...9,291,608
Ensembl chr20:9,273,594...9,291,610
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity ISO galangin results in decreased activity of GSTP1 protein CTD PMID:15041478 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression
ISO ferrous sulfate inhibits the reaction [galangin results in increased expression of HIF1A protein]; galangin promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]; galangin promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Iron inhibits the reaction [galangin results in increased expression of HIF1A protein] CTD PMID:17973296, PMID:20153296 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hrh1 histamine receptor H 1 decreases expression ISO galangin results in decreased expression of HRH1 mRNA CTD PMID:23535185 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO galangin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:16987811 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO galangin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL1B mRNA] CTD PMID:23535185 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO
galangin inhibits the reaction [Fructose results in increased expression of IL6 protein]
galangin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 mRNA]
CTD PMID:21708140, PMID:23535185 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO galangin results in decreased phosphorylation of MTOR protein CTD PMID:25450235 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO galangin promotes the reaction [NCOA1 protein binds to NR1I2 protein] CTD PMID:26238175 NCBI chr 6:28,677,563...28,931,844
Ensembl chr 6:28,677,540...28,931,843
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO galangin promotes the reaction [NCOA2 protein binds to NR1I2 protein] CTD PMID:26238175 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Ncoa3 nuclear receptor coactivator 3 multiple interactions ISO galangin promotes the reaction [NCOA3 protein binds to NR1I2 protein] CTD PMID:26238175 NCBI chr 3:162,692,176...162,788,582
Ensembl chr 3:162,692,185...162,787,548
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases expression ISO galangin results in decreased expression of NFE2L2 protein CTD PMID:29113808 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO galangin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased degradation of NFKBIA protein] CTD PMID:23535185 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO galangin binds to and results in increased activity of NR1I2 protein; galangin promotes the reaction [NCOA1 protein binds to NR1I2 protein]; galangin promotes the reaction [NCOA2 protein binds to NR1I2 protein]; galangin promotes the reaction [NCOA3 protein binds to NR1I2 protein]
galangin results in increased activity of NR1I2 protein
CTD PMID:26238175 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects localization
increases expression
ISO galangin affects the localization of NR1I3 protein
galangin results in increased expression of NR1I3 mRNA
CTD PMID:25625231 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO galangin results in increased cleavage of PARP1 protein CTD PMID:18455702 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO galangin results in decreased phosphorylation of RB1 protein CTD PMID:25450235 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO
galangin inhibits the reaction [Fructose affects the localization of RELA protein]
galangin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] affects the localization of RELA protein]
CTD PMID:21708140, PMID:23535185 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO galangin results in decreased phosphorylation of RPS6KB1 protein CTD PMID:25450235 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Sele selectin E multiple interactions ISO galangin inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:16987811 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Smad1 SMAD family member 1 increases expression
multiple interactions
increases phosphorylation
ISO galangin results in increased expression of SMAD1 mRNA
LY2109761 inhibits the reaction [galangin results in increased phosphorylation of SMAD1 protein]
CTD PMID:25268046 NCBI chr19:32,182,942...32,248,694
Ensembl chr19:32,188,267...32,248,684
JBrowse link
G Smad2 SMAD family member 2 increases expression
multiple interactions
increases phosphorylation
ISO galangin results in increased expression of SMAD2 mRNA
LY2109761 inhibits the reaction [galangin results in increased phosphorylation of SMAD2 protein]
CTD PMID:25268046 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad3 SMAD family member 3 increases expression
multiple interactions
increases phosphorylation
ISO galangin results in increased expression of SMAD3 mRNA
LY2109761 inhibits the reaction [galangin results in increased phosphorylation of SMAD3 protein]
CTD PMID:25268046 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Smad4 SMAD family member 4 multiple interactions
increases expression
ISO SMAD4 mutant form inhibits the reaction [galangin results in increased expression of ATG12 protein]; SMAD4 mutant form inhibits the reaction [galangin results in increased expression of ATG16L1 protein]; SMAD4 mutant form inhibits the reaction [galangin results in increased expression of ATG3 protein]; SMAD4 mutant form inhibits the reaction [galangin results in increased expression of BECN1 protein]
galangin results in increased expression of SMAD4 mRNA
CTD PMID:25268046 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Smad6 SMAD family member 6 decreases expression ISO galangin results in decreased expression of SMAD6 mRNA CTD PMID:25268046 NCBI chr 8:68,897,746...68,967,221
Ensembl chr 8:68,898,296...68,966,108
JBrowse link
G Smad7 SMAD family member 7 decreases expression ISO galangin results in decreased expression of SMAD7 mRNA CTD PMID:25268046 NCBI chr18:71,395,830...71,424,164
Ensembl chr18:71,395,830...71,424,157
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO galangin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of STAT3 protein] CTD PMID:20153296 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP galangin inhibits the reaction [Fructose results in increased expression of TGFB1 protein] CTD PMID:21708140 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 increases expression ISO galangin results in increased expression of TGFBR1 mRNA CTD PMID:25268046 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 increases expression ISO galangin results in increased expression of TGFBR2 mRNA CTD PMID:25268046 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
galangin inhibits the reaction [Fructose results in increased expression of TNF mRNA]; galangin inhibits the reaction [Fructose results in increased expression of TNF protein]
galangin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF mRNA]; galangin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; galangin inhibits the reaction [TNF protein results in increased expression of SELE protein]
CTD PMID:16987811, PMID:21708140, PMID:23535185 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tyr tyrosinase increases expression ISO galangin results in increased expression of TYR mRNA CTD PMID:21071833 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of galangin CTD PMID:14557274 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of galangin CTD PMID:14557274 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of galangin CTD PMID:14557274 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO galangin promotes the reaction [Oxygen deficiency results in increased expression of and results in increased localization of VEGFA protein] CTD PMID:20153296 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
genkwanin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing
decreases activity
ISO CYP1A1 protein results in increased metabolism of genkwanin
genkwanin results in decreased activity of CYP1A1 protein
CTD PMID:19666078, PMID:21482471 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing ISO CYP1A2 protein results in increased metabolism of genkwanin CTD PMID:19666078 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing
multiple interactions
ISO CYP1B1 protein results in increased metabolism of genkwanin
[CYP1B1 protein results in increased metabolism of genkwanin] which results in increased chemical synthesis of Apigenin
CTD PMID:19666078 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
hinokiflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO hinokiflavone results in increased expression of BAX protein CTD PMID:30575109, PMID:32252563 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO hinokiflavone results in decreased expression of BCL2 protein CTD PMID:30575109, PMID:32252563 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases expression
increases cleavage
ISO hinokiflavone results in increased expression of CASP3 protein
hinokiflavone results in increased cleavage of CASP3 protein
CTD PMID:30575109, PMID:32252563 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO hinokiflavone inhibits the reaction [IL1B protein results in increased secretion of F3 protein]; hinokiflavone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of F3 protein] CTD PMID:8882428 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO hinokiflavone inhibits the reaction [IL1B protein results in increased secretion of F3 protein] CTD PMID:8882428 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:29673161 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:29673161 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:29673161 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO hinokiflavone results in decreased expression of MMP2 mRNA; hinokiflavone results in decreased expression of MMP2 protein CTD PMID:29635122, PMID:30575109 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO hinokiflavone results in decreased expression of MMP9 protein
hinokiflavone results in decreased expression of MMP9 mRNA; hinokiflavone results in decreased expression of MMP9 protein
CTD PMID:29635122, PMID:30575109 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:29673161 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Prpf40a pre-mRNA processing factor 40 homolog A increases sumoylation ISO hinokiflavone results in increased sumoylation of PRPF40A protein CTD PMID:28884683 NCBI chr 3:38,680,583...38,741,570
Ensembl chr 3:38,682,146...38,741,113
JBrowse link
G Ptgds prostaglandin D2 synthase affects binding ISO hinokiflavone binds to PTGDS protein CTD PMID:26456343 NCBI chr 3:2,686,125...2,689,059
Ensembl chr 3:2,686,123...2,689,084
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:29673161 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:29673161 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Senp1 SUMO specific peptidase 1 decreases activity ISO hinokiflavone results in decreased activity of SENP1 protein CTD PMID:28884683 NCBI chr 7:139,626,444...139,684,587
Ensembl chr 7:139,630,515...139,675,245
JBrowse link
G Sf3a2 splicing factor 3a, subunit 2 increases sumoylation ISO hinokiflavone results in increased sumoylation of SF3A2 protein CTD PMID:28884683 NCBI chr 7:11,777,826...11,784,373
Ensembl chr 7:11,777,826...11,783,849
JBrowse link
G Sf3b1 splicing factor 3b, subunit 1 increases sumoylation ISO hinokiflavone results in increased sumoylation of SF3B1 protein CTD PMID:28884683 NCBI chr 9:61,594,620...61,634,510
Ensembl chr 9:61,594,620...61,634,510
JBrowse link
G Sf3b2 splicing factor 3b, subunit 2 increases sumoylation ISO hinokiflavone results in increased sumoylation of SF3B2 protein CTD PMID:28884683 NCBI chr 1:220,645,685...220,665,611
Ensembl chr 1:220,645,672...220,665,603
JBrowse link
G Snrpd2 small nuclear ribonucleoprotein D2 polypeptide increases sumoylation ISO hinokiflavone results in increased sumoylation of SNRPD2 protein CTD PMID:28884683 NCBI chr 1:80,057,140...80,059,990
Ensembl chr 1:80,056,755...80,059,996
JBrowse link
G Sumo1 small ubiquitin-like modifier 1 increases localization ISO hinokiflavone results in increased localization of SUMO1 protein CTD PMID:28884683 NCBI chr 9:66,453,428...66,483,614
Ensembl chr 9:66,453,438...66,483,614
JBrowse link
G Sumo2 small ubiquitin-like modifier 2 increases localization ISO hinokiflavone results in increased localization of SUMO2 protein CTD PMID:28884683 NCBI chr10:104,085,401...104,097,983
Ensembl chr10:104,086,002...104,097,812
JBrowse link
G Sumo3 small ubiquitin-like modifier 3 increases localization ISO hinokiflavone results in increased localization of SUMO3 protein CTD PMID:28884683 NCBI chr20:11,726,488...11,737,050
Ensembl chr20:11,726,497...11,737,050
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO hinokiflavone results in increased expression of TIMP2 mRNA; hinokiflavone results in increased expression of TIMP2 protein CTD PMID:30575109 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:29673161 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G U2surp U2 snRNP-associated SURP domain containing increases sumoylation ISO hinokiflavone results in increased sumoylation of U2SURP protein CTD PMID:28884683 NCBI chr 8:103,242,095...103,299,082
Ensembl chr 8:103,246,558...103,298,927
JBrowse link
hispidulin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ protein] CTD PMID:30055130 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of CEBPA mRNA] CTD PMID:30055130 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Ins2 insulin 2 multiple interactions ISO hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ protein]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of CEBPA mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG protein] CTD PMID:30055130 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK1 protein] CTD PMID:22759588 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK3 protein] CTD PMID:22759588 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG protein] CTD PMID:30055130 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 multiple interactions
decreases activity
EXP [hispidulin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [hispidulin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Methotrexate CTD PMID:32259555 NCBI chr 4:176,158,174...176,231,331
Ensembl chr 4:176,158,640...176,231,344
JBrowse link
G Syn1 synapsin I affects response to substance ISO SYN1 protein affects the susceptibility to hispidulin CTD PMID:22759588 NCBI chr  X:1,321,315...1,379,202
Ensembl chr  X:1,321,315...1,379,198
JBrowse link
jaceosidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO jaceosidin results in increased expression of and results in increased activity of BAX protein CTD PMID:27729209 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Casp3 caspase 3 increases activity ISO jaceosidin results in increased activity of CASP3 protein CTD PMID:27729209 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression
multiple interactions
ISO jaceosidin results in decreased expression of CFLAR mRNA; jaceosidin results in decreased expression of CFLAR protein
CFLAR protein inhibits the reaction [jaceosidin results in increased cleavage of PARP1 protein]; RELA protein inhibits the reaction [jaceosidin results in decreased expression of CFLAR protein]; SP1 protein inhibits the reaction [jaceosidin results in decreased expression of CFLAR protein]
CTD PMID:27729209 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression
multiple interactions
ISO jaceosidin results in decreased expression of MCL1 mRNA; jaceosidin results in decreased expression of MCL1 protein
MCL1 protein inhibits the reaction [jaceosidin results in increased cleavage of PARP1 protein]; RELA protein inhibits the reaction [jaceosidin results in decreased expression of MCL1 protein]; SP1 protein inhibits the reaction [jaceosidin results in decreased expression of MCL1 protein]
CTD PMID:27729209 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO jaceosidin results in increased cleavage of PARP1 protein
benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [jaceosidin results in increased cleavage of PARP1 protein]; CFLAR protein inhibits the reaction [jaceosidin results in increased cleavage of PARP1 protein]; MCL1 protein inhibits the reaction [jaceosidin results in increased cleavage of PARP1 protein]
CTD PMID:27729209 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO RELA protein inhibits the reaction [jaceosidin results in decreased expression of CFLAR protein]; RELA protein inhibits the reaction [jaceosidin results in decreased expression of MCL1 protein] CTD PMID:27729209 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO SP1 protein inhibits the reaction [jaceosidin results in decreased expression of CFLAR protein]; SP1 protein inhibits the reaction [jaceosidin results in decreased expression of MCL1 protein] CTD PMID:27729209 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
kaempferide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc2a1 solute carrier family 2 member 1 decreases expression ISO kaempferide results in decreased expression of SLC2A1 mRNA CTD PMID:21865046 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO kaempferide results in increased expression of VEGFA mRNA CTD PMID:21865046 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
kaempferol 3-O-beta-D-galactoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pla2g2a phospholipase A2 group IIA affects activity ISO kaempferol-3-O-galactoside affects the activity of PLA2G2A protein CTD PMID:8190018 NCBI chr 5:157,282,650...157,285,295
Ensembl chr 5:157,282,669...157,285,328
JBrowse link
kaempferol 3-O-beta-D-glucoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA] CTD PMID:22210036 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA] CTD PMID:22210036 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] CTD PMID:22210036 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:22210036 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO astragalin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein] CTD PMID:22210036 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:22210036 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:22210036 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO astragalin inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein] CTD PMID:22210036 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:22210036 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgb1 high mobility group box 1 multiple interactions
decreases response to substance
ISO kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of ICAM1 protein]; kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of SELE protein]; kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of TLR2 protein]; kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of TLR4 protein]; kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of VCAM1 protein]; kaempferol 3-O-sophoroside inhibits the reaction [Lipopolysaccharides results in increased secretion of HMGB1 protein]
kaempferol 3-O-sophoroside results in decreased susceptibility to HMGB1 protein
CTD PMID:22178603 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of ICAM1 protein] CTD PMID:22178603 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Sele selectin E multiple interactions ISO kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of SELE protein] CTD PMID:22178603 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of TLR2 protein] CTD PMID:22178603 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of TLR4 protein] CTD PMID:22178603 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of VCAM1 protein] CTD PMID:22178603 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
luteolin 7-O-beta-D-glucoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [luteolin-7-glucoside co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein CTD PMID:31157476 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO luteolin-7-glucoside inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein] CTD PMID:31157476 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions ISO luteolin-7-glucoside inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein] CTD PMID:31157476 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions ISO luteolin-7-glucoside inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein] CTD PMID:31157476 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Il6 interleukin 6 multiple interactions ISO luteolin-7-glucoside inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 protein] CTD PMID:11123379 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO luteolin-7-glucoside inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein] CTD PMID:11123379 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
morusin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh1 cadherin 1 increases expression ISO morusin results in increased expression of CDH1 protein CTD PMID:25476160 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO morusin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CDH2 protein] CTD PMID:28108223 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Ctsb cathepsin B decreases metabolic processing ISO morusin results in decreased metabolism of CTSB protein CTD PMID:29421517 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Ctsd cathepsin D decreases metabolic processing ISO morusin results in decreased metabolism of CTSD protein CTD PMID:29421517 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [morusin results in increased expression of DDIT3 protein] CTD PMID:29421517 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO morusin results in increased expression of ERN1 protein CTD PMID:29421517 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [morusin results in increased expression of HSPA5 protein] CTD PMID:29421517 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Itga2 integrin subunit alpha 2 decreases expression ISO morusin results in decreased expression of ITGA2 protein CTD PMID:25476160 NCBI chr 2:46,996,904...47,097,011
Ensembl chr 2:47,000,323...47,096,961
JBrowse link
G Itga6 integrin subunit alpha 6 decreases expression ISO morusin results in decreased expression of ITGA6 protein CTD PMID:25476160 NCBI chr 3:58,442,904...58,515,124
Ensembl chr 3:58,443,101...58,515,124
JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression ISO morusin results in decreased expression of ITGB1 protein CTD PMID:25476160 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO morusin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of JUN protein] CTD PMID:28108223 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO morusin results in decreased expression of and results in decreased activity of MMP2 protein CTD PMID:25476160 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO morusin results in decreased expression of and results in decreased activity of MMP9 protein CTD PMID:25476160 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein decreases expression
multiple interactions
ISO morusin results in decreased expression of PDCD6IP protein
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [morusin results in decreased expression of PDCD6IP protein]
CTD PMID:29421517 NCBI chr 8:121,916,233...121,973,145
Ensembl chr 8:121,916,185...121,973,125
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO morusin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] CTD PMID:28108223 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases phosphorylation
multiple interactions
ISO morusin results in decreased phosphorylation of RELA protein
morusin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RELA protein]
morusin results in decreased phosphorylation of and affects the localization of RELA protein
CTD PMID:25476160, PMID:28108223 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sqstm1 sequestosome 1 increases expression
multiple interactions
ISO morusin results in increased expression of SQSTM1 protein
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [morusin results in increased expression of SQSTM1 protein]
CTD PMID:29421517 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases phosphorylation
ISO morusin results in decreased phosphorylation of and affects the localization of STAT3 protein
morusin results in decreased phosphorylation of STAT3 protein
CTD PMID:25476160 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Vim vimentin decreases expression
multiple interactions
ISO morusin results in decreased expression of VIM protein
morusin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VIM protein]
CTD PMID:25476160, PMID:28108223 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
scutellarein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
multiple interactions
affects metabolic processing
ISO scutellarein results in decreased activity of CYP1A1 protein
[CYP1A1 protein affects the metabolism of scutellarein] which results in increased chemical synthesis of 6-hydroxyluteolin
CTD PMID:19666078, PMID:21482471 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing ISO CYP1A2 protein affects the metabolism of scutellarein CTD PMID:19666078 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity
affects metabolic processing
multiple interactions
ISO scutellarein results in decreased activity of CYP1B1 protein
CYP1B1 protein affects the metabolism of scutellarein
[CYP1B1 protein affects the metabolism of scutellarein] which results in increased chemical synthesis of 6-hydroxyluteolin
CTD PMID:19666078, PMID:21482471 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
scutellarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions EXP scutellarin inhibits the reaction [APP protein binds to APP protein] CTD PMID:17323972 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP scutellarin inhibits the reaction [cobaltous chloride results in decreased expression of BCL2L1 mRNA] CTD PMID:18442013 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 multiple interactions EXP scutellarin inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein] CTD PMID:18442013 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:25192544 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression EXP scutellarin results in decreased expression of FGF2 protein CTD PMID:16297343 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [scutellarin results in decreased expression of HIF1A protein]; epoxomicin inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; epoxomicin inhibits the reaction [scutellarin results in decreased expression of HIF1A protein]; MG 262 inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; MG 262 inhibits the reaction [scutellarin results in decreased expression of HIF1A protein]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose co-treated with Cycloheximide] results in decreased expression of HIF1A protein]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein]]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of and results in decreased ubiquitination of HIF1A protein]; scutellarin promotes the reaction [Cycloheximide inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]] CTD PMID:25192544 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of MKI67 mRNA]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of MKI67 protein] CTD PMID:25192544 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression EXP scutellarin results in decreased expression of NOS2 protein CTD PMID:16297343 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression EXP scutellarin results in increased expression of NOS3 protein CTD PMID:16297343 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of PCNA mRNA]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of PCNA protein] CTD PMID:25192544 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pkm pyruvate kinase M1/2 increases activity ISO scutellarin results in increased activity of PKM protein CTD PMID:25388478 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Pla2g2a phospholipase A2 group IIA affects activity ISO scutellarin affects the activity of PLA2G2A protein CTD PMID:8190018 NCBI chr 5:157,282,650...157,285,295
Ensembl chr 5:157,282,669...157,285,328
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions
EXP
ISO
scutellarin results in decreased expression of VEGFA protein
scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of VEGFA mRNA]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of VEGFA protein]
CTD PMID:16297343, PMID:25192544 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
vitexin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO vitexin results in increased expression of ABCA1 mRNA CTD PMID:29545167 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Apoe apolipoprotein E increases expression ISO vitexin results in increased expression of APOE mRNA CTD PMID:29545167 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in decreased abundance of Glutathione]; vitexin inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein]; vitexin inhibits the reaction [APP protein modified form results in decreased expression of HMOX1 mRNA]; vitexin inhibits the reaction [APP protein modified form results in decreased expression of HSPA5 mRNA]; vitexin inhibits the reaction [APP protein modified form results in decreased expression of NFE2L2 mRNA]; vitexin inhibits the reaction [APP protein modified form results in increased abundance of Malondialdehyde]; vitexin inhibits the reaction [APP protein modified form results in increased abundance of Reactive Nitrogen Species]; vitexin inhibits the reaction [APP protein modified form results in increased abundance of Reactive Oxygen Species]; vitexin inhibits the reaction [APP protein modified form results in increased activity of CASP3 protein]; vitexin inhibits the reaction [APP protein modified form results in increased expression of BAX protein]; vitexin inhibits the reaction [APP protein modified form results in increased expression of DDIT3 mRNA]; vitexin inhibits the reaction [APP protein modified form results in increased expression of PPID mRNA] CTD PMID:29545167 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in increased expression of BAX protein] CTD PMID:29545167 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein] CTD PMID:29545167 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in increased activity of CASP3 protein] CTD PMID:29545167 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in increased expression of DDIT3 mRNA] CTD PMID:29545167 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase increases expression ISO vitexin results in increased expression of DHCR24 mRNA CTD PMID:29545167 NCBI chr 5:126,164,708...126,188,926
Ensembl chr 5:126,164,674...126,191,206
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO vitexin inhibits the reaction [Streptozocin results in decreased expression of FSHB protein] CTD PMID:30365938 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in decreased expression of HMOX1 mRNA] CTD PMID:29545167 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in decreased expression of HSPA5 mRNA] CTD PMID:29545167 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions ISO vitexin inhibits the reaction [Streptozocin results in decreased expression of LHB protein] CTD PMID:30365938 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in decreased expression of NFE2L2 mRNA] CTD PMID:29545167 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression ISO vitexin results in increased expression of NR1H3 mRNA CTD PMID:29545167 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
JBrowse link
G Ppid peptidylprolyl isomerase D multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in increased expression of PPID mRNA] CTD PMID:29545167 NCBI chr 2:178,354,830...178,366,843
Ensembl chr 2:178,354,890...178,366,685
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    chemical entity 19810
      molecular entity 19808
        polyatomic entity 19721
          heteroatomic molecular entity 19647
            hydroxides 19103
              organic hydroxy compound 18658
                hydroxyflavone 4159
                  trihydroxyflavone 339
                    2''-O-(4-sinapoylarabinosyl)isoscoparin 0
                    2''-O-(6-feruloylglucosyl)isovitexin 0
                    2''-O-(6-sinapoylglucosyl)isovitexin 0
                    2''-O-(beta-D-glucosyl)isovitexin 0
                    2''-O-alpha-L-arabinopyranosylisoscoparin 0
                    2''-O-beta-D-glucosylisoscoparin 0
                    2''-O-rhamnosylscoparin 0
                    2''-acetylastragalin 0
                    2''-acetylpetiolaroside 0
                    2-(3,4-dihydroxyphenyl)-8-(1,1-dioxidoisothiazolidin-2-yl)-3-hydroxy-6-methyl-4H-chromen-4-one 0
                    2-(3-benzoylphenyl)-3,5,7-trihydroxychromen-4-one 0
                    3',4',5,7-tetrahydroxy-3-methoxyflavone-7-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranoside 0
                    3',4',5-trihydroxy-3,6,7-trimethoxyflavone 0
                    3',4',5-trihydroxy-3,7-dimethoxyflavone 6
                    3',5'-di-O-methyltricetin + 1
                    3'-O-methyltricetin 3-O-alpha-L-rhamnopyranoside 0
                    3,3',5'-trimethylmyricetin 0