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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:androst-5-ene-3beta,17beta-diol
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Accession:CHEBI:2710 term browser browse the term
Definition:A 3beta-hydroxy steroid that is 3beta-hydroxyandrost-5-ene carrying an additional hydroxy group at position 17beta.
Synonyms:related_synonym: (3beta,17beta)-androst-5-ene-3,17-diol;   3beta,17beta-Dihydroxy-5-androstene;   3beta,17beta-Dihydroxyandrost-5-ene;   5-androstenediol;   Androstenediol;   Formula=C19H30O2;   InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-17,20-21H,4-11H2,1-2H3/t13-,14-,15-,16-,17-,18-,19-/m0/s1;   InChIKey=QADHLRWLCPCEKT-LOVVWNRFSA-N;   SMILES=[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@@H](O)CC[C@]12C;   androst-5-en-3beta,17beta-diol;   androst-5-enediol;   hermaphrodiol
 xref: CAS:521-17-5;   Chemspider:10188;   DrugBank:DB01524;   Drug_Central:214;   FooDB:FDB023228;   HMDB:HMDB0003818;   KEGG:C04295;   KEGG:D00179;   LIPID_MAPS_instance:LMST02020005
 xref_mesh: MESH:D015114
 xref: PDBeChem:B81;   PMID:10438974;   PMID:10995038;   PMID:17078923;   PMID:20620158;   PMID:31726369;   Patent:WO9963973


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androst-5-ene-3beta,17beta-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor affects binding EXP Androstenediol binds to AR protein CTD PMID:14565775 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Dhrs11 dehydrogenase/reductase 11 increases oxidation ISO DHRS11 protein results in increased oxidation of Androstenediol CTD PMID:30926317 NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Androstenediol inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein] CTD PMID:9048584 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases expression		 EXP
ISO		 Androstenediol inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein]
Androstenediol results in increased expression of ESR2 protein
ESR2 protein alternative form inhibits the reaction [Androstenediol results in increased expression of ESR2 protein]		 CTD PMID:9048584 PMID:27634370 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 affects metabolic processing
increases chemical synthesis		 ISO HSD17B1 protein affects the metabolism of Androstenediol
HSD17B1 protein results in increased chemical synthesis of Androstenediol		 CTD PMID:16054388 NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927 		JBrowse link
G Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 increases chemical synthesis ISO HSD17B12 protein results in increased chemical synthesis of Androstenediol CTD PMID:17641292 NCBI chr 3:79,990,048...80,113,556
Ensembl chr 3:79,990,056...80,113,617 		JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 increases chemical synthesis
affects metabolic processing		 ISO HSD17B2 protein results in increased chemical synthesis of Androstenediol
HSD17B2 protein affects the metabolism of Androstenediol		 CTD PMID:16054388 NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 affects metabolic processing
increases chemical synthesis		 ISO HSD17B4 protein affects the metabolism of Androstenediol
HSD17B4 protein results in increased chemical synthesis of Androstenediol		 CTD PMID:16054388 NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 affects metabolic processing ISO HSD3B1 protein affects the metabolism of Androstenediol CTD PMID:16054388 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999 		JBrowse link
G Sts steroid sulfatase decreases activity ISO Androstenediol metabolite results in decreased activity of STS protein CTD PMID:11600235 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      biological role 20007
        molecular messenger 18621
          hormone 18475
            sex hormone 18249
              androgen 5687
                androst-5-ene-3beta,17beta-diol 10
                  androstenediol 3-sulfate(1-) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic molecule 19822
                              organic cyclic compound 19575
                                organic polycyclic compound 17176
                                  steroid 14380
                                    hydroxy steroid 14096
                                      3-hydroxy steroid 12143
                                        3beta-hydroxy steroid 2018
                                          3beta-hydroxy-Delta(5)-steroid 1848
                                            androst-5-ene-3beta,17beta-diol 10
                                              androstenediol 3-sulfate(1-) 0
paths to the root