CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: androst-5-ene-3beta,17beta-diol
Accession: CHEBI:2710
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Definition: A 3beta-hydroxy steroid that is 3beta-hydroxyandrost-5-ene carrying an additional hydroxy group at position 17beta.
Synonyms: related_synonym: (3beta,17beta)-androst-5-ene-3,17-diol; 3beta,17beta-Dihydroxy-5-androstene; 3beta,17beta-Dihydroxyandrost-5-ene; Androstenediol; Formula=C19H30O2; InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-17,20-21H,4-11H2,1-2H3/t13-,14-,15-,16-,17-,18-,19-/m0/s1; InChIKey=QADHLRWLCPCEKT-LOVVWNRFSA-N; SMILES=[H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](O)CC[C@@]21[H]; androst-5-en-3beta,17beta-diol; androst-5-enediol; hermaphrodiol
xref: CAS:521-17-5; Drug_Central:214; KEGG:C04295; KEGG:D00179; LIPID_MAPS_instance:LMST02020005
xref_mesh: MESH:D015114
xref: PMID:10438974
G
Ar
androgen receptor
affects binding
EXP
Androstenediol binds to AR protein
CTD
PMID:14565775
NCBI chr X:67,656,253...67,828,998
Ensembl chr X:67,656,253...67,829,026
G
Dhrs11
dehydrogenase/reductase 11
increases oxidation
ISO
DHRS11 protein results in increased oxidation of Androstenediol
CTD
PMID:30926317
NCBI chr10:72,144,042...72,153,496
Ensembl chr10:72,144,042...72,153,375
G
Esr1
estrogen receptor 1
multiple interactions
ISO
Androstenediol inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]
CTD
PMID:9048584
NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
G
Esr2
estrogen receptor 2
multiple interactions increases expression
EXP ISO
Androstenediol inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein] Androstenediol results in increased expression of ESR2 protein ESR2 protein alternative form inhibits the reaction [Androstenediol results in increased expression of ESR2 protein]
CTD
PMID:9048584 PMID:27634370
NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
G
Hsd17b1
hydroxysteroid (17-beta) dehydrogenase 1
affects metabolic processing increases chemical synthesis
ISO
HSD17B1 protein affects the metabolism of Androstenediol HSD17B1 protein results in increased chemical synthesis of Androstenediol
CTD
PMID:16054388
NCBI chr10:88,987,558...88,989,758
Ensembl chr10:88,987,558...88,989,757
G
Hsd17b12
hydroxysteroid (17-beta) dehydrogenase 12
increases chemical synthesis
ISO
HSD17B12 protein results in increased chemical synthesis of Androstenediol
CTD
PMID:17641292
NCBI chr 3:82,924,699...83,048,465
Ensembl chr 3:82,924,687...83,048,435
G
Hsd17b2
hydroxysteroid (17-beta) dehydrogenase 2
increases chemical synthesis affects metabolic processing
ISO
HSD17B2 protein results in increased chemical synthesis of Androstenediol HSD17B2 protein affects the metabolism of Androstenediol
CTD
PMID:16054388
NCBI chr19:50,246,404...50,317,892
Ensembl chr19:50,246,402...50,317,891
G
Hsd17b4
hydroxysteroid (17-beta) dehydrogenase 4
affects metabolic processing increases chemical synthesis
ISO
HSD17B4 protein affects the metabolism of Androstenediol HSD17B4 protein results in increased chemical synthesis of Androstenediol
CTD
PMID:16054388
NCBI chr18:44,810,462...44,897,677
Ensembl chr18:44,810,388...44,897,640
G
Hsd3b1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
affects metabolic processing
ISO
HSD3B1 protein affects the metabolism of Androstenediol
CTD
PMID:16054388
G
Sts
steroid sulfatase
decreases activity
ISO
Androstenediol metabolite results in decreased activity of STS protein
CTD
PMID:11600235
NCBI chr X:45,420,418...45,428,748
Ensembl chr X:45,420,596...45,428,750
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