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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:androst-5-ene-3beta,17beta-diol
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Accession:CHEBI:2710 term browser browse the term
Definition:A 3beta-hydroxy steroid that is 3beta-hydroxyandrost-5-ene carrying an additional hydroxy group at position 17beta.
Synonyms:related_synonym: (3beta,17beta)-androst-5-ene-3,17-diol;   3beta,17beta-Dihydroxy-5-androstene;   3beta,17beta-Dihydroxyandrost-5-ene;   Androstenediol;   Formula=C19H30O2;   InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-17,20-21H,4-11H2,1-2H3/t13-,14-,15-,16-,17-,18-,19-/m0/s1;   InChIKey=QADHLRWLCPCEKT-LOVVWNRFSA-N;   SMILES=[H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](O)CC[C@@]21[H];   androst-5-en-3beta,17beta-diol;   androst-5-enediol;   hermaphrodiol
 xref: CAS:521-17-5;   Drug_Central:214;   KEGG:C04295;   KEGG:D00179;   LIPID_MAPS_instance:LMST02020005
 xref_mesh: MESH:D015114
 xref: PMID:10438974


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androst-5-ene-3beta,17beta-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor affects binding EXP Androstenediol binds to AR protein CTD PMID:14565775 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Dhrs11 dehydrogenase/reductase 11 increases oxidation ISO DHRS11 protein results in increased oxidation of Androstenediol CTD PMID:30926317 NCBI chr10:72,144,042...72,153,496
Ensembl chr10:72,144,042...72,153,375
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Androstenediol inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein] CTD PMID:9048584 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases expression
EXP
ISO
Androstenediol inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein]
Androstenediol results in increased expression of ESR2 protein
ESR2 protein alternative form inhibits the reaction [Androstenediol results in increased expression of ESR2 protein]
CTD PMID:9048584 PMID:27634370 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 affects metabolic processing
increases chemical synthesis
ISO HSD17B1 protein affects the metabolism of Androstenediol
HSD17B1 protein results in increased chemical synthesis of Androstenediol
CTD PMID:16054388 NCBI chr10:88,987,558...88,989,758
Ensembl chr10:88,987,558...88,989,757
JBrowse link
G Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 increases chemical synthesis ISO HSD17B12 protein results in increased chemical synthesis of Androstenediol CTD PMID:17641292 NCBI chr 3:82,924,699...83,048,465
Ensembl chr 3:82,924,687...83,048,435
JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 increases chemical synthesis
affects metabolic processing
ISO HSD17B2 protein results in increased chemical synthesis of Androstenediol
HSD17B2 protein affects the metabolism of Androstenediol
CTD PMID:16054388 NCBI chr19:50,246,404...50,317,892
Ensembl chr19:50,246,402...50,317,891
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 affects metabolic processing
increases chemical synthesis
ISO HSD17B4 protein affects the metabolism of Androstenediol
HSD17B4 protein results in increased chemical synthesis of Androstenediol
CTD PMID:16054388 NCBI chr18:44,810,462...44,897,677
Ensembl chr18:44,810,388...44,897,640
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 affects metabolic processing ISO HSD3B1 protein affects the metabolism of Androstenediol CTD PMID:16054388
G Sts steroid sulfatase decreases activity ISO Androstenediol metabolite results in decreased activity of STS protein CTD PMID:11600235 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750
JBrowse link

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  CHEBI ontology 19770
    role 19720
      biological role 19720
        molecular messenger 18298
          hormone 18068
            sex hormone 17963
              androgen 4655
                androst-5-ene-3beta,17beta-diol 10
Path 2
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  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic molecule 19504
                              organic cyclic compound 19331
                                organic polycyclic compound 16515
                                  steroid 13050
                                    hydroxy steroid 12649
                                      3-hydroxy steroid 10362
                                        3beta-hydroxy steroid 2004
                                          3beta-hydroxy-Delta(5)-steroid 1836
                                            androst-5-ene-3beta,17beta-diol 10
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