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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:transition element atom
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Accession:CHEBI:27081 term browser browse the term
Definition:An element whose atom has an incomplete d sub-shell, or which can give rise to cations with an incomplete d sub-shell.
Synonyms:related_synonym: Uebergangselement;   Uebergangsmetalle;   metal de transicion;   metal de transition;   metales de transicion;   metaux de transition;   transition element;   transition elements;   transition metal;   transition metals



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cadmium atom term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACADM acyl-CoA dehydrogenase medium chain multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ACADM mRNA CTD PMID:34416349 NCBI chr 6:137,541,481...137,575,544
Ensembl chr 6:137,541,380...137,595,108
JBrowse link
G ACOX1 acyl-CoA oxidase 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ACOX1 mRNA CTD PMID:34416349 NCBI chr12:5,450,913...5,479,550
Ensembl chr12:5,428,360...5,479,544
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of AKT1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased phosphorylation of AKT1 protein CTD PMID:33493553
G ARG1 arginase 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of ARG1 mRNA CTD PMID:34416349 NCBI chr 1:32,006,035...32,028,983
Ensembl chr 1:32,006,038...32,028,986
JBrowse link
G ATF4 activating transcription factor 4 multiple interactions
increases expression
EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ATF4 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ATF4 protein; Cycloheximide inhibits the reaction [Cadmium results in increased expression of ATF4 protein]
Cadmium results in increased expression of ATF4 mRNA; Cadmium results in increased expression of ATF4 protein
CTD PMID:16759985 PMID:33891997 NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,738,880...8,745,225
JBrowse link
G ATF6 activating transcription factor 6 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ATF6 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ATF6 protein CTD PMID:33891997 NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,280...88,818,372
JBrowse link
G BAK1 BCL2 antagonist/killer 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAK1 mRNA CTD PMID:33493553 NCBI chr 7:29,808,849...29,815,345 JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of BAX protein]; Selenium inhibits the reaction [Cadmium results in increased expression of BAX protein] CTD PMID:19135140 PMID:33493553 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144
JBrowse link
G BBC3 BCL2 binding component 3 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BBC3 mRNA CTD PMID:33891997 NCBI chr 6:53,037,103...53,046,902 JBrowse link
G BCL2L11 BCL2 like 11 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BCL2L11 mRNA CTD PMID:33891997 NCBI chr 3:45,156,791...45,202,996 JBrowse link
G CASP1 caspase 1, apoptosis-related cysteine peptidase multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP1 protein CTD PMID:33592257 PMID:34416349 NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328
JBrowse link
G CASP3 caspase 3 increases activity
multiple interactions
increases cleavage
EXP Cadmium results in increased activity of CASP3 protein
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP3 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of and results in increased cleavage of CASP3 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP3 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP3 protein; Acetylcysteine inhibits the reaction [Cadmium results in increased activity of CASP3 protein]; oxalomalic acid promotes the reaction [Cadmium results in increased cleavage of CASP3 protein]; Selenium inhibits the reaction [Cadmium results in increased activity of CASP3 protein]
CTD PMID:16785314 PMID:19135140 PMID:33493553 PMID:33891997 PMID:34416349 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CASP9 caspase 9 multiple interactions
increases activity
EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP9 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP9 mRNA; Acetylcysteine inhibits the reaction [Cadmium results in increased activity of CASP9 protein]; Selenium inhibits the reaction [Cadmium results in increased activity of CASP9 protein] CTD PMID:19135140 PMID:33493553 PMID:33891997 NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,515...74,730,092
JBrowse link
G CAT catalase affects response to substance
multiple interactions
EXP CAT affects the susceptibility to Cadmium
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CAT mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CAT mRNA
CTD PMID:18086661 PMID:33493553 PMID:34416349 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CCL2 mRNA CTD PMID:34416349 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,028
JBrowse link
G CCL24 C-C motif chemokine ligand 24 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CCL24 mRNA CTD PMID:34416349 NCBI chr 3:10,347,397...10,361,500 JBrowse link
G COL3A1 collagen type III alpha 1 chain multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of COL3A1 mRNA CTD PMID:34416349 NCBI chr15:93,556,914...93,595,678
Ensembl chr15:93,556,912...93,615,815
JBrowse link
G COL4A1 collagen type IV alpha 1 chain multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of COL4A1 mRNA CTD PMID:34416349 NCBI chr11:76,858,332...76,997,409 JBrowse link
G CORT cortistatin multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CORT protein CTD PMID:34416349 NCBI chr 6:70,716,630...70,717,980
Ensembl chr 6:70,716,296...70,718,268
JBrowse link
G COX4I1 cytochrome c oxidase subunit 4I1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of COX4 mRNA CTD PMID:34416349 NCBI chr 6:3,131,017...3,137,619
Ensembl chr 6:3,131,019...3,240,221
JBrowse link
G CPT1A carnitine palmitoyltransferase 1A multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CPT1A mRNA CTD PMID:34416349 NCBI chr 2:4,250,642...4,293,914
Ensembl chr 2:4,233,099...4,293,984
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CXCL8 mRNA CTD PMID:33891997 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
JBrowse link
G CXCL9 C-X-C motif chemokine ligand 9 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CXCL9 mRNA CTD PMID:34416349 NCBI chr 8:71,665,541...71,670,236
Ensembl chr 8:71,663,495...71,670,271
JBrowse link
G CYCS cytochrome c, somatic multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CYCS mRNA CTD PMID:33493553 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of DDIT3 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of DDIT3 protein CTD PMID:33891997 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,441...22,791,134
JBrowse link
G DENR density regulated re-initiation and release factor multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of DENR mRNA CTD PMID:33592257 NCBI chr14:30,070,810...30,084,997
Ensembl chr14:30,069,485...30,084,949
JBrowse link
G EIF2A eukaryotic translation initiation factor 2A increases phosphorylation
multiple interactions
EXP Cadmium results in increased phosphorylation of EIF2A protein
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of EIF2A mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of EIF2A protein
CTD PMID:16759985 PMID:33891997 NCBI chr13:90,761,453...90,804,274
Ensembl chr13:90,761,465...90,804,276
JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of EIF2AK3 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of EIF2AK3 protein CTD PMID:33891997 NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,875...57,506,247
JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ERN1 protein CTD PMID:33891997 NCBI chr12:14,881,913...14,963,290
Ensembl chr12:14,881,923...14,997,426
JBrowse link
G ERO1A endoplasmic reticulum oxidoreductase 1 alpha multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ERO1A mRNA CTD PMID:33891997 NCBI chr 1:182,268,651...182,318,147
Ensembl chr 1:182,265,261...182,318,195
JBrowse link
G FGD4 FYVE, RhoGEF and PH domain containing 4 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of DNM1L mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of DNM1L protein CTD PMID:33493553 NCBI chr 5:41,571,054...41,636,058 JBrowse link
G FIS1 fission, mitochondrial 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of FIS1 mRNA CTD PMID:33592257 NCBI chr 3:8,938,250...8,942,102
Ensembl chr 3:8,931,104...8,941,865
JBrowse link
G FN1 fibronectin 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of FN1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of FN1 protein CTD PMID:34416349 NCBI chr15:117,658,158...117,737,145
Ensembl chr15:117,658,099...117,731,014
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of GCLC mRNA CTD PMID:33493553 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,564...27,253,535
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of GCLM mRNA CTD PMID:33493553 NCBI chr 4:123,371,198...123,390,130
Ensembl chr 4:123,371,193...123,390,135
JBrowse link
G GLRX glutaredoxin decreases activity
multiple interactions
EXP Cadmium results in decreased activity of GLRX protein
GLRX protein inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]; IDH2 protein inhibits the reaction [Cadmium results in decreased activity of GLRX protein]; oxalomalic acid promotes the reaction [Cadmium results in decreased activity of GLRX protein]
CTD PMID:16785314 NCBI chr 2:102,425,580...102,437,851 JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of GPX1 mRNA CTD PMID:33493553 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,914,932...31,917,335
JBrowse link
G GPX4 glutathione peroxidase 4 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of GPX4 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of GPX4 mRNA CTD PMID:33493553 PMID:34416349 NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,886
JBrowse link
G GSTO1 glutathione S-transferase omega 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of GSTO1 mRNA CTD PMID:34416349 NCBI chr14:115,206,434...115,216,624
Ensembl chr14:115,206,188...115,216,613
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HIF1A mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HIF1A protein CTD PMID:33493553 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,181...190,674,850
JBrowse link
G HK2 hexokinase 2 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HK2 mRNA CTD PMID:34416349 NCBI chr 3:68,155,656...68,231,187
Ensembl chr 3:68,145,890...68,231,615
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HMOX1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HMOX1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HMOX1 protein CTD PMID:33493553 PMID:33592257 PMID:34416349
G HSP90B1 heat shock protein 90 beta family member 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HSP90B1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HSP90B1 protein CTD PMID:33891997 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,507...80,531,005
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HSPA5 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HSPA5 protein; Cycloheximide inhibits the reaction [Cadmium results in increased expression of HSPA5 protein]; Dactinomycin inhibits the reaction [Cadmium results in increased expression of HSPA5 protein]
Cadmium results in increased expression of HSPA5 mRNA; Cadmium results in increased expression of HSPA5 protein
CTD PMID:16759985 PMID:33891997 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
G HSPA6 heat shock protein family A (Hsp70) member 6 increases expression EXP Cadmium results in increased expression of HSP70 protein CTD PMID:12915104 PMID:16759985 NCBI chr 4:88,970,592...88,973,109
Ensembl chr 4:88,970,591...88,985,586
JBrowse link
G HSPB1 heat shock protein family B (small) member 1 increases expression EXP Cadmium results in increased expression of HSP27 protein CTD PMID:12915104 NCBI chr 3:10,038,074...10,039,441
Ensembl chr 3:10,037,936...10,039,915
JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 affects binding
decreases response to substance
affects folding
decreases activity
multiple interactions
EXP Cadmium binds to IDH2 protein
IDH2 protein results in decreased susceptibility to Cadmium
Cadmium affects the folding of IDH2 protein
Cadmium results in decreased activity of IDH2 protein
[oxalomalic acid results in decreased activity of IDH2 protein] which results in increased susceptibility to Cadmium; Dithiothreitol inhibits the reaction [Cadmium results in decreased activity of IDH2 protein]; Glutathione inhibits the reaction [Cadmium results in decreased activity of IDH2 protein]; IDH2 protein inhibits the reaction [Cadmium results in decreased activity of GLRX protein]
CTD PMID:16785314 NCBI chr 7:55,654,298...55,675,571
Ensembl chr 7:55,651,606...55,681,426
JBrowse link
G IFNG interferon gamma multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IFNG mRNA CTD PMID:33592257 PMID:33891997 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,848...32,482,752
JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IKBKB mRNA CTD PMID:33592257 NCBI chr17:11,289,607...11,348,557
Ensembl chr17:11,289,690...11,348,553
JBrowse link
G IL10 interleukin 10 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IL10 mRNA CTD PMID:33592257 PMID:34416349 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,727...67,405,711
JBrowse link
G IL13 interleukin 13 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IL13 mRNA CTD PMID:33891997 NCBI chr 2:134,972,099...134,976,672
Ensembl chr 2:134,972,623...134,975,093
JBrowse link
G IL17A interleukin 17A multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL17A mRNA CTD PMID:33592257 NCBI chr 7:46,013,584...46,017,161
Ensembl chr 7:46,013,584...46,017,153
JBrowse link
G IL18 interleukin 18 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL18 mRNA CTD PMID:33592257 PMID:34416349 NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,966...39,873,300
JBrowse link
G IL1A interleukin 1 alpha multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL1A mRNA CTD PMID:33592257 NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,119
JBrowse link
G IL2 interleukin 2 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL2 mRNA CTD PMID:33592257 NCBI chr 8:101,640,938...101,645,683
Ensembl chr 8:101,640,944...101,645,609
JBrowse link
G IL4 interleukin 4 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IL4 mRNA CTD PMID:33891997 PMID:34416349 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365
JBrowse link
G IL6 interleukin 6 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL6 mRNA CTD PMID:33592257 PMID:33891997 PMID:34416349 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G IL7 interleukin 7 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL7 mRNA CTD PMID:33592257 NCBI chr 4:57,677,895...57,744,713
Ensembl chr 4:57,685,069...57,753,797
JBrowse link
G ITPR1 inositol 1,4,5-trisphosphate receptor type 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ITPR1 mRNA CTD PMID:33891997 NCBI chr13:61,068,131...61,398,918
Ensembl chr13:61,068,126...61,398,908
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of JUN protein CTD PMID:33891997 NCBI chr 6:153,686,425...153,687,635 JBrowse link
G LDHA lactate dehydrogenase A multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of LDHA mRNA; Cadmium binds to and results in decreased folding of LDHA protein CTD PMID:18501191 PMID:34416349 NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,812,453...40,826,715
JBrowse link
G LOC110258578 interleukin-1 beta-like multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL1B mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL1B protein CTD PMID:33592257 PMID:34416349
G MFF mitochondrial fission factor multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MFF mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MFF protein CTD PMID:33493553 NCBI chr15:128,768,441...128,799,355
Ensembl chr15:128,768,348...128,799,345
JBrowse link
G MFN1 mitofusin 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of MFN1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of MFN1 protein CTD PMID:33493553 PMID:33592257 NCBI chr13:117,404,637...117,441,750
Ensembl chr13:117,404,699...117,442,481
JBrowse link
G MFN2 mitofusin 2 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of MFN2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of MFN2 protein CTD PMID:33493553 PMID:33592257 NCBI chr 6:72,026,512...72,056,439
Ensembl chr 6:72,026,722...72,056,439
JBrowse link
G MIR125A microRNA mir-125a multiple interactions EXP Sodium Selenite inhibits the reaction [Cadmium results in decreased expression of MIR125A mRNA] CTD PMID:26607349 NCBI chr 6:58,331,566...58,331,645
Ensembl chr 6:58,331,566...58,331,645
JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MMP2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MMP2 protein CTD PMID:34416349 NCBI chr 6:30,059,247...30,087,031
Ensembl chr 6:30,058,594...30,086,982
JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MMP9 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MMP9 protein CTD PMID:34416349 NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,175,056...48,188,264
JBrowse link
G MRC1 mannose receptor C-type 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of MRC1 mRNA CTD PMID:34416349 NCBI chr10:44,107,926...44,226,734
Ensembl chr10:44,107,072...44,244,410
JBrowse link
G MT1A metallothionein 1A increases expression EXP Cadmium results in increased expression of MT1A protein CTD PMID:12915104 NCBI chr 6:18,672,016...18,673,673
Ensembl chr 6:18,660,642...18,673,766
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor increases expression EXP Cadmium results in increased expression of MYC mRNA CTD PMID:11781163 NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,119...12,461,078
JBrowse link
G NDUFB8 NADH:ubiquinone oxidoreductase subunit B8 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NDUFB8 mRNA CTD PMID:34416349 NCBI chr14:111,626,827...111,633,548
Ensembl chr14:111,626,095...111,633,564
JBrowse link
G NFE2 nuclear factor, erythroid 2 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of NFE2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of NFE2 protein CTD PMID:33592257 NCBI chr 5:19,494,672...19,501,810
Ensembl chr 5:19,494,677...19,501,810
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NFE2L2 mRNA CTD PMID:34416349 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NFKB1 mRNA CTD PMID:33592257 PMID:34416349 NCBI chr 8:118,391,010...118,478,927
Ensembl chr 8:118,390,637...118,506,691
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NFKBIA mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of and results in increased ubiquitination of NFKBIA protein CTD PMID:33592257 NCBI chr 7:64,508,119...64,510,754
Ensembl chr 7:64,508,016...64,558,057
JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 protein CTD PMID:33592257 PMID:34416349 NCBI chr 2:56,892,241...56,977,412
Ensembl chr 2:56,892,242...56,977,234
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NOS2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NOS2 protein CTD PMID:33592257 PMID:34416349 NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,944...44,327,111
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of NQO1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NQO1 mRNA CTD PMID:33493553 PMID:34416349 NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,769...17,302,590
JBrowse link
G NRF1 nuclear respiratory factor 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of NRF1 mRNA CTD PMID:33592257 NCBI chr18:19,008,408...19,142,678
Ensembl chr18:18,998,905...19,142,628
JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of OPA1 mRNA CTD PMID:33592257 NCBI chr13:130,624,771...130,718,345
Ensembl chr13:130,624,823...130,719,083
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage
multiple interactions
EXP Cadmium results in increased cleavage of PARP1 protein
GLRX protein inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]; oxalomalic acid promotes the reaction [Cadmium results in increased cleavage of PARP1 protein]
CTD PMID:16785314 NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,159...14,241,197
JBrowse link
G PDK1 pyruvate dehydrogenase kinase 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PDK1 mRNA CTD PMID:34416349 NCBI chr15:78,608,394...78,650,958
Ensembl chr15:78,608,360...78,652,962
JBrowse link
G PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PFKFB3 mRNA CTD PMID:34416349 NCBI chr10:64,776,315...64,859,118
Ensembl chr10:64,776,315...64,859,051
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PIK3CG mRNA CTD PMID:33493553 NCBI chr 9:106,698,200...106,748,217
Ensembl chr 9:106,698,207...106,745,099
JBrowse link
G PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PMAIP1 mRNA CTD PMID:33891997 NCBI chr 1:161,184,458...161,188,138
Ensembl chr 1:161,182,868...161,188,164
JBrowse link
G POMC proopiomelanocortin multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of POMC protein CTD PMID:34416349 NCBI chr 3:113,661,712...113,668,558
Ensembl chr 3:113,661,004...113,670,418
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PPARA mRNA CTD PMID:34416349 NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,708...3,366,361
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PPARGC1A mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PPARGC1A protein CTD PMID:33592257 NCBI chr 8:17,841,844...18,527,953
Ensembl chr 8:17,841,844...17,961,909
JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PRKAA1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PRKAA1 mRNA CTD PMID:33592257 PMID:34416349 NCBI chr16:25,745,902...25,783,524
Ensembl chr16:25,745,321...25,783,610
JBrowse link
G PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PRKAA2 mRNA CTD PMID:34416349 NCBI chr 6:155,683,392...155,754,283
Ensembl chr 6:155,681,781...155,754,272
JBrowse link
G PRKAB1 protein kinase AMP-activated non-catalytic subunit beta 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PRKAB1 mRNA CTD PMID:34416349 NCBI chr14:33,201,359...33,217,641
Ensembl chr14:33,193,568...33,217,538
JBrowse link
G PRKAG1 protein kinase AMP-activated non-catalytic subunit gamma 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PRKAG1 mRNA CTD PMID:34416349 NCBI chr 5:15,033,051...15,049,676
Ensembl chr 5:15,033,053...15,049,660
JBrowse link
G PRKAG3 protein kinase AMP-activated non-catalytic subunit gamma 3 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PRKAG3 mRNA CTD PMID:34416349 NCBI chr15:120,859,486...120,866,308
Ensembl chr15:120,855,194...120,866,332
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PTGS2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PTGS2 protein CTD PMID:33592257 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,013...127,858,884
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of RELA protein CTD PMID:34416349 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,471
JBrowse link
G SDHB succinate dehydrogenase complex iron sulfur subunit B multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SDHB mRNA CTD PMID:34416349 NCBI chr 6:75,648,362...75,678,111
Ensembl chr 6:75,648,215...75,678,378
JBrowse link
G SERPINE1 serpin family E member 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SERPINE1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SERPINE1 protein CTD PMID:34416349 NCBI chr 3:8,863,738...8,871,572
Ensembl chr 3:8,863,695...8,871,564
JBrowse link
G SMAD2 SMAD family member 2 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SMAD2 mRNA CTD PMID:34416349 NCBI chr 1:97,415,360...97,511,388
Ensembl chr 1:97,415,716...97,511,358
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SOD1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SOD1 mRNA CTD PMID:33493553 PMID:34416349 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SOD2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SOD2 mRNA CTD PMID:33493553 PMID:34416349 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,651,280...7,691,723
JBrowse link
G STAT1 signal transducer and activator of transcription 1 multiple interactions
increases phosphorylation
EXP SB 203580 inhibits the reaction [Cadmium results in increased phosphorylation of STAT1 protein] CTD PMID:21783819 NCBI chr15:95,593,201...95,646,324
Ensembl chr15:95,593,211...95,646,260
JBrowse link
G STAT3 signal transducer and activator of transcription 3 increases phosphorylation
multiple interactions
EXP Cadmium results in increased phosphorylation of STAT3 protein
SB 203580 inhibits the reaction [Cadmium results in increased phosphorylation of STAT3 protein]
CTD PMID:21783819 NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,993
JBrowse link
G TFAM transcription factor A, mitochondrial multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TFAM mRNA CTD PMID:33592257 NCBI chr14:92,261,713...92,279,731
Ensembl chr14:92,259,403...92,279,550
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TGFB1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TGFB1 protein CTD PMID:34416349 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,169...49,349,048
JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TIMP1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TIMP1 protein CTD PMID:34416349 NCBI chr  X:42,103,251...42,106,289
Ensembl chr  X:42,102,172...42,106,297
JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TIMP2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TIMP2 protein CTD PMID:34416349 NCBI chr12:3,254,794...3,300,835
Ensembl chr12:3,254,493...3,300,835
JBrowse link
G TLR4 toll like receptor 4 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TLR4 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TLR4 protein CTD PMID:34416349 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,059,004
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF mRNA CTD PMID:33891997 PMID:34416349 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNFRSF1A mRNA CTD PMID:33592257 NCBI chr 5:64,319,349...64,331,876
Ensembl chr 5:64,319,073...64,331,909
JBrowse link
G TRAF2 TNF receptor associated factor 2 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TRAF2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TRAF2 protein CTD PMID:33891997
G TRAF6 TNF receptor associated factor 6 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TRAF6 mRNA CTD PMID:33592257 NCBI chr 2:24,602,749...24,628,263
Ensembl chr 2:24,602,783...24,626,072
JBrowse link
G TWNK twinkle mtDNA helicase multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TWNK mRNA CTD PMID:33592257 NCBI chr14:112,068,463...112,076,169
Ensembl chr14:112,066,846...112,075,822
JBrowse link
G UQCRQ ubiquinol-cytochrome c reductase complex III subunit VII multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of UQCRQ mRNA CTD PMID:34416349 NCBI chr 2:135,186,366...135,188,237
Ensembl chr 2:135,186,479...135,188,295
JBrowse link
G XBP1 X-box binding protein 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of XBP1 mRNA alternative form CTD PMID:33891997 NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,017,036
JBrowse link
cadmium dichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACADM acyl-CoA dehydrogenase medium chain multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ACADM mRNA CTD PMID:34416349 NCBI chr 6:137,541,481...137,575,544
Ensembl chr 6:137,541,380...137,595,108
JBrowse link
G ACOX1 acyl-CoA oxidase 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ACOX1 mRNA CTD PMID:34416349 NCBI chr12:5,450,913...5,479,550
Ensembl chr12:5,428,360...5,479,544
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of AKT1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased phosphorylation of AKT1 protein CTD PMID:33493553
G ALOX15 arachidonate 15-lipoxygenase increases expression EXP Cadmium Chloride results in increased expression of ALOX15 mRNA CTD PMID:33626375 NCBI chr12:52,287,174...52,295,873
Ensembl chr12:52,286,019...52,414,907
JBrowse link
G ALOX5 arachidonate 5-lipoxygenase increases expression EXP Cadmium Chloride results in increased expression of ALOX5 mRNA CTD PMID:33626375 NCBI chr14:90,859,209...90,907,084
Ensembl chr14:90,858,975...90,907,094
JBrowse link
G AQP1 aquaporin 1 (Colton blood group) increases expression EXP Cadmium Chloride results in increased expression of AQP1 mRNA CTD PMID:20576581 NCBI chr18:42,063,482...42,076,741
Ensembl chr18:42,063,481...42,076,746
JBrowse link
G ARG1 arginase 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of ARG1 mRNA CTD PMID:34416349 NCBI chr 1:32,006,035...32,028,983
Ensembl chr 1:32,006,038...32,028,986
JBrowse link
G ATF4 activating transcription factor 4 multiple interactions
increases expression
EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ATF4 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ATF4 protein; Cycloheximide inhibits the reaction [Cadmium Chloride results in increased expression of ATF4 protein]
Cadmium Chloride results in increased expression of ATF4; Cadmium Chloride results in increased expression of ATF4 mRNA; Cadmium Chloride results in increased expression of ATF4 protein
CTD PMID:16759985 PMID:20600546 PMID:33891997 NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,738,880...8,745,225
JBrowse link
G ATF6 activating transcription factor 6 increases cleavage
multiple interactions
EXP Cadmium Chloride results in increased cleavage of ATF6 protein
4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [Cadmium Chloride results in increased cleavage of ATF6 protein]; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ATF6 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ATF6 protein
CTD PMID:17464326 PMID:33891997 NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,280...88,818,372
JBrowse link
G BAK1 BCL2 antagonist/killer 1 multiple interactions
increases expression
EXP [Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAK1 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAK1 mRNA; MIR125A mRNA inhibits the reaction [Cadmium Chloride results in increased expression of BAK1 protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAK1 protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in increased expression of BAK1 protein] CTD PMID:26607349 PMID:33493553 NCBI chr 7:29,808,849...29,815,345 JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP Cadmium Chloride results in increased expression of BAX protein
[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAX protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein; MIR125A mRNA inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAX protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]
CTD PMID:26607349 PMID:33493553 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144
JBrowse link
G BBC3 BCL2 binding component 3 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BBC3 mRNA CTD PMID:33891997 NCBI chr 6:53,037,103...53,046,902 JBrowse link
G BCL2L11 BCL2 like 11 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BCL2L11 mRNA CTD PMID:33891997 NCBI chr 3:45,156,791...45,202,996 JBrowse link
G CASP1 caspase 1, apoptosis-related cysteine peptidase multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP1 protein CTD PMID:33592257 PMID:34416349 NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328
JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity
increases expression
increases cleavage
EXP [Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP3 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP3 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of and results in increased cleavage of CASP3 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP3 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP3 protein; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; MIR125A mRNA inhibits the reaction [Cadmium Chloride results in increased expression of CASP3 protein]; oxalomalic acid promotes the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]; Selenium inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP3 protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in increased expression of CASP3 protein] CTD PMID:16785314 PMID:17383151 PMID:26607349 PMID:33493553 PMID:33891997 More... NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CASP9 caspase 9 increases expression
multiple interactions
EXP Cadmium Chloride results in increased expression of CASP9 protein
[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP9 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP9 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP9 mRNA; MIR125A mRNA inhibits the reaction [Cadmium Chloride results in increased expression of CASP9 protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP9 protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in increased expression of CASP9 protein]
CTD PMID:26607349 PMID:33493553 PMID:33891997 NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,515...74,730,092
JBrowse link
G CAT catalase decreases activity
decreases expression
multiple interactions
EXP Cadmium Chloride results in decreased activity of CAT protein
Cadmium Chloride results in decreased expression of CAT mRNA
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CAT mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CAT mRNA; CAT inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 mRNA]
CTD PMID:18086661 PMID:23904328 PMID:33493553 PMID:33626375 PMID:34416349 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CCL2 mRNA CTD PMID:34416349 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,028
JBrowse link
G CCL24 C-C motif chemokine ligand 24 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CCL24 mRNA CTD PMID:34416349 NCBI chr 3:10,347,397...10,361,500 JBrowse link
G CLIC5 chloride intracellular channel 5 decreases expression
multiple interactions
increases degradation
EXP Cadmium Chloride results in decreased expression of CLIC5 mRNA; Cadmium Chloride results in decreased expression of CLIC5 protein
bafilomycin A inhibits the reaction [Cadmium Chloride results in decreased expression of CLIC5 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Cadmium Chloride results in decreased expression of CLIC5 protein]; Cycloheximide promotes the reaction [Cadmium Chloride results in decreased expression of CLIC5 protein]
Cadmium Chloride results in increased degradation of CLIC5 protein
CTD PMID:20576581 NCBI chr 7:40,683,044...40,808,017
Ensembl chr 7:40,682,907...40,863,886
JBrowse link
G COL3A1 collagen type III alpha 1 chain multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of COL3A1 mRNA CTD PMID:34416349 NCBI chr15:93,556,914...93,595,678
Ensembl chr15:93,556,912...93,615,815
JBrowse link
G COL4A1 collagen type IV alpha 1 chain multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of COL4A1 mRNA CTD PMID:34416349 NCBI chr11:76,858,332...76,997,409 JBrowse link
G CORT cortistatin multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CORT protein CTD PMID:34416349 NCBI chr 6:70,716,630...70,717,980
Ensembl chr 6:70,716,296...70,718,268
JBrowse link
G COX4I1 cytochrome c oxidase subunit 4I1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of COX4 mRNA CTD PMID:34416349 NCBI chr 6:3,131,017...3,137,619
Ensembl chr 6:3,131,019...3,240,221
JBrowse link
G CPT1A carnitine palmitoyltransferase 1A multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CPT1A mRNA CTD PMID:34416349 NCBI chr 2:4,250,642...4,293,914
Ensembl chr 2:4,233,099...4,293,984
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression
multiple interactions
EXP Cadmium Chloride results in increased expression of CXCL8 mRNA
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CXCL8 mRNA
CTD PMID:33626375 PMID:33891997 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
JBrowse link
G CXCL9 C-X-C motif chemokine ligand 9 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CXCL9 mRNA CTD PMID:34416349 NCBI chr 8:71,665,541...71,670,236
Ensembl chr 8:71,663,495...71,670,271
JBrowse link
G CYCS cytochrome c, somatic multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CYCS mRNA CTD PMID:33493553 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression
multiple interactions
EXP Cadmium Chloride results in increased expression of DDIT3 mRNA
4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA]; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of DDIT3 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of DDIT3 protein; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA]; SOD2 inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA]
CTD PMID:17464326 PMID:18086661 PMID:33891997 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,441...22,791,134
JBrowse link
G DENR density regulated re-initiation and release factor multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of DENR mRNA CTD PMID:33592257 NCBI chr14:30,070,810...30,084,997
Ensembl chr14:30,069,485...30,084,949
JBrowse link
G EGR1 early growth response 1 increases expression EXP Cadmium Chloride results in increased expression of EGR1 mRNA CTD PMID:7564105 NCBI chr 2:140,440,829...140,445,302
Ensembl chr 2:140,441,421...140,445,296
JBrowse link
G EIF2A eukaryotic translation initiation factor 2A increases phosphorylation
multiple interactions
EXP Cadmium Chloride results in increased phosphorylation of EIF2A protein
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of EIF2A mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of EIF2A protein
CTD PMID:16759985 PMID:17464326 PMID:33891997 NCBI chr13:90,761,453...90,804,274
Ensembl chr13:90,761,465...90,804,276
JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation
multiple interactions
EXP Cadmium Chloride results in increased phosphorylation of EIF2AK3 protein
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of EIF2AK3 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of EIF2AK3 protein
CTD PMID:17464326 PMID:33891997 NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,875...57,506,247
JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation EXP Cadmium Chloride results in increased phosphorylation of EIF2S1 protein CTD PMID:20600546 NCBI chr 7:91,085,025...91,109,835
Ensembl chr 7:91,085,335...91,109,829
JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ERN1 protein CTD PMID:33891997 NCBI chr12:14,881,913...14,963,290
Ensembl chr12:14,881,923...14,997,426
JBrowse link
G ERO1A endoplasmic reticulum oxidoreductase 1 alpha multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ERO1A mRNA CTD PMID:33891997 NCBI chr 1:182,268,651...182,318,147
Ensembl chr 1:182,265,261...182,318,195
JBrowse link
G FGD4 FYVE, RhoGEF and PH domain containing 4 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of DNM1L mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of DNM1L protein CTD PMID:33493553 NCBI chr 5:41,571,054...41,636,058 JBrowse link
G FIS1 fission, mitochondrial 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of FIS1 mRNA CTD PMID:33592257 NCBI chr 3:8,938,250...8,942,102
Ensembl chr 3:8,931,104...8,941,865
JBrowse link
G FN1 fibronectin 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of FN1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of FN1 protein CTD PMID:34416349 NCBI chr15:117,658,158...117,737,145
Ensembl chr15:117,658,099...117,731,014
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
EXP Cadmium Chloride results in increased expression of FOS mRNA
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA]
CTD PMID:7564105 PMID:18086661 NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of GCLC mRNA CTD PMID:33493553 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,564...27,253,535
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of GCLM mRNA CTD PMID:33493553 NCBI chr 4:123,371,198...123,390,130
Ensembl chr 4:123,371,193...123,390,135
JBrowse link
G GLRX glutaredoxin decreases activity
multiple interactions
EXP Cadmium Chloride results in decreased activity of GLRX protein
GLRX protein inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein]; IDH2 protein inhibits the reaction [Cadmium Chloride results in decreased activity of GLRX protein]; oxalomalic acid promotes the reaction [Cadmium Chloride results in decreased activity of GLRX protein]
CTD PMID:16785314 NCBI chr 2:102,425,580...102,437,851 JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions
decreases expression
EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of GPX1 mRNA
Cadmium Chloride results in decreased expression of GPX1 mRNA
CTD PMID:33493553 PMID:33626375 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,914,932...31,917,335
JBrowse link
G GPX4 glutathione peroxidase 4 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of GPX4 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of GPX4 mRNA CTD PMID:33493553 PMID:34416349 NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,886
JBrowse link
G GSTO1 glutathione S-transferase omega 1 decreases expression
multiple interactions
EXP Cadmium Chloride results in decreased expression of GSTO1 mRNA
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of GSTO1 mRNA
CTD PMID:33626375 PMID:34416349 NCBI chr14:115,206,434...115,216,624
Ensembl chr14:115,206,188...115,216,613
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HIF1A mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HIF1A protein CTD PMID:33493553 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,181...190,674,850
JBrowse link
G HK2 hexokinase 2 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HK2 mRNA CTD PMID:34416349 NCBI chr 3:68,155,656...68,231,187
Ensembl chr 3:68,145,890...68,231,615
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HMOX1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HMOX1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HMOX1 protein CTD PMID:33493553 PMID:33592257 PMID:34416349
G HSP90B1 heat shock protein 90 beta family member 1 multiple interactions
increases expression
EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HSP90B1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HSP90B1 protein; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HSP90B1 mRNA] CTD PMID:17464326 PMID:18086661 PMID:33891997 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,507...80,531,005
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases phosphorylation
decreases response to substance
decreases expression
multiple interactions
increases expression
EXP Cadmium Chloride results in increased phosphorylation of HSPA5 protein
HSPA5 results in decreased susceptibility to Cadmium Chloride
Cadmium Chloride results in decreased expression of HSPA5 mRNA
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HSPA5 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HSPA5 protein; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 mRNA]; CAT inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 mRNA]; Cycloheximide inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 protein]; Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 protein]; SOD2 inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 mRNA]; SOD2 inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 protein]
Cadmium Chloride results in increased expression of HSPA5 mRNA; Cadmium Chloride results in increased expression of HSPA5 protein
CTD PMID:16759985 PMID:17464326 PMID:18086661 PMID:20576581 PMID:20600546 More... NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
G HSPA6 heat shock protein family A (Hsp70) member 6 increases expression EXP Cadmium Chloride results in increased expression of HSP70 protein CTD PMID:16759985 NCBI chr 4:88,970,592...88,973,109
Ensembl chr 4:88,970,591...88,985,586
JBrowse link
G HYOU1 hypoxia up-regulated 1 decreases response to substance EXP HYOU1 results in decreased susceptibility to Cadmium Chloride CTD PMID:17464326 NCBI chr 9:46,264,929...46,277,056
Ensembl chr 9:46,264,929...46,276,996
JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 affects binding
decreases activity
multiple interactions
affects folding
decreases response to substance
EXP Cadmium Chloride binds to IDH2 protein
Cadmium Chloride results in decreased activity of IDH2 protein
[oxalomalic acid results in decreased activity of IDH2 protein] which results in increased susceptibility to Cadmium Chloride; Dithiothreitol inhibits the reaction [Cadmium Chloride results in decreased activity of IDH2 protein]; Glutathione inhibits the reaction [Cadmium Chloride results in decreased activity of IDH2 protein]; IDH2 protein inhibits the reaction [Cadmium Chloride results in decreased activity of GLRX protein]
Cadmium Chloride affects the folding of IDH2 protein
IDH2 protein results in decreased susceptibility to Cadmium Chloride
CTD PMID:16785314 NCBI chr 7:55,654,298...55,675,571
Ensembl chr 7:55,651,606...55,681,426
JBrowse link
G IFNG interferon gamma multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IFNG mRNA CTD PMID:33592257 PMID:33891997 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,848...32,482,752
JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IKBKB mRNA CTD PMID:33592257 NCBI chr17:11,289,607...11,348,557
Ensembl chr17:11,289,690...11,348,553
JBrowse link
G IL10 interleukin 10 multiple interactions
decreases expression
EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IL10 mRNA
Cadmium Chloride results in decreased expression of IL10 mRNA
CTD PMID:33592257 PMID:33626375 PMID:34416349 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,727...67,405,711
JBrowse link
G IL13 interleukin 13 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IL13 mRNA CTD PMID:33891997 NCBI chr 2:134,972,099...134,976,672
Ensembl chr 2:134,972,623...134,975,093
JBrowse link
G IL17A interleukin 17A multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL17A mRNA CTD PMID:33592257 NCBI chr 7:46,013,584...46,017,161
Ensembl chr 7:46,013,584...46,017,153
JBrowse link
G IL18 interleukin 18 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL18 mRNA CTD PMID:33592257 PMID:34416349 NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,966...39,873,300
JBrowse link
G IL1A interleukin 1 alpha multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL1A mRNA CTD PMID:33592257 NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,119
JBrowse link
G IL2 interleukin 2 multiple interactions
increases expression
EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL2 mRNA
Cadmium Chloride results in increased expression of IL2 mRNA
CTD PMID:33592257 PMID:33626375 NCBI chr 8:101,640,938...101,645,683
Ensembl chr 8:101,640,944...101,645,609
JBrowse link
G IL4 interleukin 4 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IL4 mRNA CTD PMID:33891997 PMID:34416349 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365
JBrowse link
G IL6 interleukin 6 multiple interactions
increases expression
EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL6 mRNA
Cadmium Chloride results in increased expression of IL6 mRNA
CTD PMID:33592257 PMID:33626375 PMID:33891997 PMID:34416349 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G IL7 interleukin 7 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL7 mRNA CTD PMID:33592257 NCBI chr 4:57,677,895...57,744,713
Ensembl chr 4:57,685,069...57,753,797
JBrowse link
G ITPR1 inositol 1,4,5-trisphosphate receptor type 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ITPR1 mRNA CTD PMID:33891997 NCBI chr13:61,068,131...61,398,918
Ensembl chr13:61,068,126...61,398,908
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
EXP Cadmium Chloride results in increased expression of JUN mRNA
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of JUN protein
CTD PMID:7564105 PMID:33891997 NCBI chr 6:153,686,425...153,687,635 JBrowse link
G LDHA lactate dehydrogenase A multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of LDHA mRNA CTD PMID:34416349 NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,812,453...40,826,715
JBrowse link
G LOC110258578 interleukin-1 beta-like multiple interactions
increases expression
EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL1B mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL1B protein
Cadmium Chloride results in increased expression of IL1B mRNA
CTD PMID:33592257 PMID:33626375 PMID:34416349
G LRP2 LDL receptor related protein 2 decreases expression
multiple interactions
increases degradation
EXP Cadmium Chloride results in decreased expression of LRP2 mRNA; Cadmium Chloride results in decreased expression of LRP2 protein
bafilomycin A inhibits the reaction [Cadmium Chloride results in decreased expression of LRP2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Cadmium Chloride results in decreased expression of LRP2 protein]; Cycloheximide promotes the reaction [Cadmium Chloride results in decreased expression of LRP2 protein]
Cadmium Chloride results in increased degradation of LRP2 protein
CTD PMID:20576581 NCBI chr15:75,565,299...75,754,604
Ensembl chr15:75,565,301...75,716,694
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
EXP 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; Selenium inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; XBP1 affects the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:10696784 PMID:17383151 PMID:17464326 PMID:18086661 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,172,200
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation
EXP 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK9 protein]; Selenium inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK9 protein] CTD PMID:10696784 PMID:17383151 NCBI chr 2:78,338,466...78,399,108
Ensembl chr 2:78,338,369...78,399,105
JBrowse link
G MFF mitochondrial fission factor multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MFF mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MFF protein CTD PMID:33493553 NCBI chr15:128,768,441...128,799,355
Ensembl chr15:128,768,348...128,799,345
JBrowse link
G MFN1 mitofusin 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of MFN1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of MFN1 protein CTD PMID:33493553 PMID:33592257 NCBI chr13:117,404,637...117,441,750
Ensembl chr13:117,404,699...117,442,481
JBrowse link
G MFN2 mitofusin 2 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of MFN2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of MFN2 protein CTD PMID:33493553 PMID:33592257 NCBI chr 6:72,026,512...72,056,439
Ensembl chr 6:72,026,722...72,056,439
JBrowse link
G MIR125A microRNA mir-125a decreases expression
multiple interactions
EXP Cadmium Chloride results in decreased expression of MIR125A mRNA
[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAK1 protein; [Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAX protein; [Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP3 protein; [Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP9 protein; Cadmium Chloride promotes the reaction [MIR125A mRNA mutant form results in decreased expression of BCL2 protein]; MIR125A mRNA inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein]; MIR125A mRNA inhibits the reaction [Cadmium Chloride results in increased expression of BAK1 protein]; MIR125A mRNA inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]; MIR125A mRNA inhibits the reaction [Cadmium Chloride results in increased expression of CASP3 protein]; MIR125A mRNA inhibits the reaction [Cadmium Chloride results in increased expression of CASP9 protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAK1 protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAX protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP3 protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP9 protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride promotes the reaction [MIR125A mRNA mutant form results in decreased expression of BCL2 protein]]
CTD PMID:26607349 NCBI chr 6:58,331,566...58,331,645
Ensembl chr 6:58,331,566...58,331,645
JBrowse link
G MLKL mixed lineage kinase domain like pseudokinase increases expression EXP Cadmium Chloride results in increased expression of MLKL mRNA; Cadmium Chloride results in increased expression of MLKL protein CTD PMID:33626375 NCBI chr 6:12,923,846...12,951,176
Ensembl chr 6:12,924,894...12,951,173
JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MMP2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MMP2 protein CTD PMID:34416349 NCBI chr 6:30,059,247...30,087,031
Ensembl chr 6:30,058,594...30,086,982
JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MMP9 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MMP9 protein CTD PMID:34416349 NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,175,056...48,188,264
JBrowse link
G MRC1 mannose receptor C-type 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of MRC1 mRNA CTD PMID:34416349 NCBI chr10:44,107,926...44,226,734
Ensembl chr10:44,107,072...44,244,410
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor increases expression EXP Cadmium Chloride results in increased expression of MYC mRNA CTD PMID:7564105 NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,119...12,461,078
JBrowse link
G NDUFB8 NADH:ubiquinone oxidoreductase subunit B8 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NDUFB8 mRNA CTD PMID:34416349 NCBI chr14:111,626,827...111,633,548
Ensembl chr14:111,626,095...111,633,564
JBrowse link
G NFE2 nuclear factor, erythroid 2 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of NFE2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of NFE2 protein CTD PMID:33592257 NCBI chr 5:19,494,672...19,501,810
Ensembl chr 5:19,494,677...19,501,810
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 decreases expression
multiple interactions
EXP Cadmium Chloride results in decreased expression of NFE2L2 mRNA; Cadmium Chloride results in decreased expression of NFE2L2 protein
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NFE2L2 mRNA
CTD PMID:33626375 PMID:34416349 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NFKB1 mRNA CTD PMID:33592257 PMID:34416349 NCBI chr 8:118,391,010...118,478,927
Ensembl chr 8:118,390,637...118,506,691
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NFKBIA mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of and results in increased ubiquitination of NFKBIA protein CTD PMID:33592257 NCBI chr 7:64,508,119...64,510,754
Ensembl chr 7:64,508,016...64,558,057
JBrowse link
G NKRF NFKB repressing factor increases expression EXP Cadmium Chloride results in increased expression of NKRF mRNA CTD PMID:33626375 NCBI chr  X:98,008,870...98,025,423
Ensembl chr  X:98,007,877...98,025,375
JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 protein CTD PMID:33592257 PMID:34416349 NCBI chr 2:56,892,241...56,977,412
Ensembl chr 2:56,892,242...56,977,234
JBrowse link
G NOS2 nitric oxide synthase 2 increases expression
multiple interactions
EXP Cadmium Chloride results in increased expression of NOS2 mRNA; Cadmium Chloride results in increased expression of NOS2 protein
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NOS2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NOS2 protein
CTD PMID:33592257 PMID:33626375 PMID:34416349 NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,944...44,327,111
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 decreases expression
multiple interactions
EXP Cadmium Chloride results in decreased expression of NQO1 mRNA
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of NQO1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NQO1 mRNA
CTD PMID:33493553 PMID:33626375 PMID:34416349 NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,769...17,302,590
JBrowse link
G NRF1 nuclear respiratory factor 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of NRF1 mRNA CTD PMID:33592257 NCBI chr18:19,008,408...19,142,678
Ensembl chr18:18,998,905...19,142,628
JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of OPA1 mRNA CTD PMID:33592257 NCBI chr13:130,624,771...130,718,345
Ensembl chr13:130,624,823...130,719,083
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions
increases cleavage
EXP GLRX protein inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein]; oxalomalic acid promotes the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein] CTD PMID:16785314 NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,159...14,241,197
JBrowse link
G PDK1 pyruvate dehydrogenase kinase 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PDK1 mRNA CTD PMID:34416349 NCBI chr15:78,608,394...78,650,958
Ensembl chr15:78,608,360...78,652,962
JBrowse link
G PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PFKFB3 mRNA CTD PMID:34416349 NCBI chr10:64,776,315...64,859,118
Ensembl chr10:64,776,315...64,859,051
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PIK3CG mRNA CTD PMID:33493553 NCBI chr 9:106,698,200...106,748,217
Ensembl chr 9:106,698,207...106,745,099
JBrowse link
G PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PMAIP1 mRNA CTD PMID:33891997 NCBI chr 1:161,184,458...161,188,138
Ensembl chr 1:161,182,868...161,188,164
JBrowse link
G POMC proopiomelanocortin multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of POMC protein CTD PMID:34416349 NCBI chr 3:113,661,712...113,668,558
Ensembl chr 3:113,661,004...113,670,418
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PPARA mRNA CTD PMID:34416349 NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,708...3,366,361
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PPARGC1A mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PPARGC1A protein CTD PMID:33592257 NCBI chr 8:17,841,844...18,527,953
Ensembl chr 8:17,841,844...17,961,909
JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PRKAA1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PRKAA1 mRNA CTD PMID:33592257 PMID:34416349 NCBI chr16:25,745,902...25,783,524
Ensembl chr16:25,745,321...25,783,610
JBrowse link
G PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PRKAA2 mRNA CTD PMID:34416349 NCBI chr 6:155,683,392...155,754,283
Ensembl chr 6:155,681,781...155,754,272
JBrowse link
G PRKAB1 protein kinase AMP-activated non-catalytic subunit beta 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PRKAB1 mRNA CTD PMID:34416349 NCBI chr14:33,201,359...33,217,641
Ensembl chr14:33,193,568...33,217,538
JBrowse link
G PRKAG1 protein kinase AMP-activated non-catalytic subunit gamma 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PRKAG1 mRNA CTD PMID:34416349 NCBI chr 5:15,033,051...15,049,676
Ensembl chr 5:15,033,053...15,049,660
JBrowse link
G PRKAG3 protein kinase AMP-activated non-catalytic subunit gamma 3 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PRKAG3 mRNA CTD PMID:34416349 NCBI chr15:120,859,486...120,866,308
Ensembl chr15:120,855,194...120,866,332
JBrowse link
G PTGER3 prostaglandin E receptor 3 increases expression EXP Cadmium Chloride results in increased expression of PTGER3 mRNA CTD PMID:33626375 NCBI chr 6:141,958,955...142,160,437
Ensembl chr 6:141,958,954...142,161,292
JBrowse link
G PTGES3 prostaglandin E synthase 3 increases expression EXP Cadmium Chloride results in increased expression of PTGES3 protein CTD PMID:33626375 NCBI chr 5:22,000,335...22,022,830
Ensembl chr 5:22,000,339...22,021,663
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
EXP Cadmium Chloride results in increased expression of PTGS2 mRNA; Cadmium Chloride results in increased expression of PTGS2 protein
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PTGS2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PTGS2 protein
CTD PMID:33592257 PMID:33626375 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,013...127,858,884
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit affects localization
multiple interactions
EXP Cadmium Chloride affects the localization of RELA protein
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of RELA protein
CTD PMID:23575899 PMID:34416349 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,471
JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 increases expression EXP Cadmium Chloride results in increased expression of RIPK1 mRNA; Cadmium Chloride results in increased expression of RIPK1 protein CTD PMID:33626375 NCBI chr 7:1,841,143...1,880,705
Ensembl chr 7:1,841,236...1,880,699
JBrowse link
G RIPK3 receptor interacting serine/threonine kinase 3 increases expression EXP Cadmium Chloride results in increased expression of RIPK3 mRNA; Cadmium Chloride results in increased expression of RIPK3 protein CTD PMID:33626375 NCBI chr 7:74,951,145...74,955,255
Ensembl chr 7:74,951,060...74,955,192
JBrowse link
G SDHB succinate dehydrogenase complex iron sulfur subunit B multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SDHB mRNA CTD PMID:34416349 NCBI chr 6:75,648,362...75,678,111
Ensembl chr 6:75,648,215...75,678,378
JBrowse link
G SERPINE1 serpin family E member 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SERPINE1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SERPINE1 protein CTD PMID:34416349 NCBI chr 3:8,863,738...8,871,572
Ensembl chr 3:8,863,695...8,871,564
JBrowse link
G SMAD2 SMAD family member 2 increases expression
multiple interactions
EXP Cadmium Chloride results in increased expression of SMAD2 mRNA
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SMAD2 mRNA
CTD PMID:33626375 PMID:34416349 NCBI chr 1:97,415,360...97,511,388
Ensembl chr 1:97,415,716...97,511,358
JBrowse link
G SMAD3 SMAD family member 3 increases expression EXP Cadmium Chloride results in increased expression of SMAD3 mRNA CTD PMID:33626375 NCBI chr 1:164,998,457...165,124,455
Ensembl chr 1:164,998,083...165,124,454
JBrowse link
G SMAD4 SMAD family member 4 increases expression EXP Cadmium Chloride results in increased expression of SMAD4 mRNA CTD PMID:33626375 NCBI chr 1:100,521,843...100,633,501
Ensembl chr 1:100,514,791...100,628,029
JBrowse link
G SMAD7 SMAD family member 7 decreases expression EXP Cadmium Chloride results in decreased expression of SMAD7 mRNA; Cadmium Chloride results in decreased expression of SMAD7 protein CTD PMID:33626375 NCBI chr 1:98,512,800...98,543,924
Ensembl chr 1:98,510,229...98,542,382
JBrowse link
G SOD1 superoxide dismutase 1 decreases expression
multiple interactions
EXP Cadmium Chloride results in decreased expression of SOD1 mRNA
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SOD1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SOD1 mRNA
CTD PMID:33493553 PMID:33626375 PMID:34416349 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
G SOD2 superoxide dismutase 2 decreases response to substance
decreases expression
multiple interactions
EXP SOD2 results in decreased susceptibility to Cadmium Chloride
Cadmium Chloride results in decreased expression of SOD2 mRNA
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SOD2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SOD2 mRNA; SOD2 inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA]; SOD2 inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 mRNA]; SOD2 inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 protein]; SOD2 inhibits the reaction [Cadmium Chloride results in increased splicing of XBP1 mRNA]
CTD PMID:18086661 PMID:33493553 PMID:33626375 PMID:34416349 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,651,280...7,691,723
JBrowse link
G TFAM transcription factor A, mitochondrial multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TFAM mRNA CTD PMID:33592257 NCBI chr14:92,261,713...92,279,731
Ensembl chr14:92,259,403...92,279,550
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions
increases expression
EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TGFB1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TGFB1 protein; Cadmium Chloride results in increased expression of and results in increased cleavage of TGFB1 protein
Cadmium Chloride results in increased expression of TGFB1 mRNA; Cadmium Chloride results in increased expression of TGFB1 protein
CTD PMID:33626375 PMID:34416349 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,169...49,349,048
JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 increases expression EXP Cadmium Chloride results in increased expression of TGFBR1 mRNA CTD PMID:33626375 NCBI chr 1:240,842,735...240,918,267
Ensembl chr 1:240,859,270...240,918,528
JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 increases expression EXP Cadmium Chloride results in increased expression of TGFBR2 mRNA CTD PMID:33626375 NCBI chr13:16,784,370...16,875,828
Ensembl chr13:16,784,491...16,878,165
JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TIMP1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TIMP1 protein CTD PMID:34416349 NCBI chr  X:42,103,251...42,106,289
Ensembl chr  X:42,102,172...42,106,297
JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TIMP2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TIMP2 protein CTD PMID:34416349 NCBI chr12:3,254,794...3,300,835
Ensembl chr12:3,254,493...3,300,835
JBrowse link
G TLR4 toll like receptor 4 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TLR4 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TLR4 protein CTD PMID:34416349 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,059,004
JBrowse link
G TNF tumor necrosis factor increases expression
multiple interactions
EXP Cadmium Chloride results in increased expression of TNF mRNA; Cadmium Chloride results in increased expression of TNF protein
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF mRNA
CTD PMID:33626375 PMID:33891997 PMID:34416349 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A multiple interactions
increases expression
EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNFRSF1A mRNA
Cadmium Chloride results in increased expression of TNFRSF1A mRNA; Cadmium Chloride results in increased expression of TNFRSF1A protein
CTD PMID:33592257 PMID:33626375 NCBI chr 5:64,319,349...64,331,876
Ensembl chr 5:64,319,073...64,331,909
JBrowse link
G TRAF2 TNF receptor associated factor 2 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TRAF2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TRAF2 protein CTD PMID:33891997
G TRAF6 TNF receptor associated factor 6 multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TRAF6 mRNA CTD PMID:33592257 NCBI chr 2:24,602,749...24,628,263
Ensembl chr 2:24,602,783...24,626,072
JBrowse link
G TWNK twinkle mtDNA helicase multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TWNK mRNA CTD PMID:33592257 NCBI chr14:112,068,463...112,076,169
Ensembl chr14:112,066,846...112,075,822
JBrowse link
G UQCRQ ubiquinol-cytochrome c reductase complex III subunit VII multiple interactions EXP [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of UQCRQ mRNA CTD PMID:34416349 NCBI chr 2:135,186,366...135,188,237
Ensembl chr 2:135,186,479...135,188,295
JBrowse link
G XBP1 X-box binding protein 1 increases splicing
multiple interactions
EXP Cadmium Chloride results in increased splicing of XBP1 mRNA
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of XBP1 mRNA alternative form; SOD2 inhibits the reaction [Cadmium Chloride results in increased splicing of XBP1 mRNA]; XBP1 affects the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]
CTD PMID:17464326 PMID:18086661 PMID:33891997 NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,017,036
JBrowse link
cadmium nitrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD14 CD14 molecule affects expression EXP cadmium nitrate affects the expression of CD14 mRNA CTD PMID:29421334 NCBI chr 2:142,348,036...142,349,686
Ensembl chr 2:142,346,358...142,349,581
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 affects expression
affects secretion
EXP cadmium nitrate affects the expression of CXCL8 mRNA
cadmium nitrate affects the secretion of CXCL8 protein
CTD PMID:29421334 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
JBrowse link
G DEFB1 defensin beta 1 increases expression EXP cadmium nitrate results in increased expression of DEFB1 mRNA CTD PMID:29421334
G IFNB1 interferon beta 1 increases expression EXP cadmium nitrate results in increased expression of IFNB1 mRNA CTD PMID:29421334 NCBI chr 1:201,850,935...201,851,495
Ensembl chr 1:201,850,935...201,851,495
JBrowse link
G IL18 interleukin 18 increases expression EXP cadmium nitrate results in increased expression of IL18 mRNA CTD PMID:29421334 NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,966...39,873,300
JBrowse link
G IL6 interleukin 6 increases expression EXP cadmium nitrate results in increased expression of IL6 mRNA CTD PMID:29421334 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G LOC110258578 interleukin-1 beta-like increases expression EXP cadmium nitrate results in increased expression of IL1B mRNA CTD PMID:29421334
G MAPK14 mitogen-activated protein kinase 14 affects expression EXP cadmium nitrate affects the expression of MAPK14 mRNA CTD PMID:29421334 NCBI chr 7:31,791,398...31,861,544
Ensembl chr 7:31,790,104...31,862,038
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases expression EXP cadmium nitrate results in increased expression of MAPK8 mRNA CTD PMID:29421334 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,172,200
JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor affects expression EXP cadmium nitrate affects the expression of MYD88 mRNA CTD PMID:29421334 NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,964,071...22,983,109
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 affects expression EXP cadmium nitrate affects the expression of NFKB1 mRNA CTD PMID:29421334 NCBI chr 8:118,391,010...118,478,927
Ensembl chr 8:118,390,637...118,506,691
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit increases expression EXP cadmium nitrate results in increased expression of RELA mRNA CTD PMID:29421334 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,471
JBrowse link
G SOCS1 suppressor of cytokine signaling 1 decreases expression EXP cadmium nitrate results in decreased expression of SOCS1 mRNA CTD PMID:29421334 NCBI chr 3:31,879,143...31,883,041
Ensembl chr 3:31,881,225...31,884,969
JBrowse link
G STAT3 signal transducer and activator of transcription 3 decreases expression EXP cadmium nitrate results in decreased expression of STAT3 mRNA CTD PMID:29421334 NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,993
JBrowse link
G TLR4 toll like receptor 4 affects expression EXP cadmium nitrate affects the expression of TLR4 mRNA CTD PMID:29421334 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,059,004
JBrowse link
G TLR5 toll like receptor 5 increases expression EXP cadmium nitrate results in increased expression of TLR5 mRNA CTD PMID:29421334 NCBI chr10:19,387,666...19,410,024
Ensembl chr10:19,387,666...19,410,024
JBrowse link
G TNF tumor necrosis factor increases expression EXP cadmium nitrate results in increased expression of TNF mRNA CTD PMID:29421334 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
cadmium selenide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 decreases activity EXP cadmium selenide results in decreased activity of CASP3 protein CTD PMID:18632727 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
chromium atom term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin decreases expression EXP Chromium results in decreased expression of INS protein CTD PMID:7628956 NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841
JBrowse link
cisplatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 multiple interactions EXP Cisplatin inhibits the reaction [ABCB1 protein results in increased susceptibility to NSC73306] CTD PMID:24800945 NCBI chr 9:93,049,955...93,146,469 JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 affects response to substance EXP AIFM1 protein affects the susceptibility to Cisplatin CTD PMID:15983031 NCBI chr  X:106,676,596...106,708,290
Ensembl chr  X:106,670,519...106,708,317
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
affects localization
EXP Bezafibrate inhibits the reaction [Cisplatin affects the localization of BAX protein] CTD PMID:16316343 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144
JBrowse link
G CASP2 caspase 2 increases expression EXP Cisplatin results in increased expression of CASP2 CTD PMID:12712633 NCBI chr18:6,946,432...6,966,088
Ensembl chr18:6,902,542...6,966,092
JBrowse link
G CASP3 caspase 3 increases expression
multiple interactions
increases activity
EXP Cisplatin results in increased expression of CASP3
[Cisplatin co-treated with EPO protein] results in increased cleavage of CASP3 protein; Bezafibrate inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]; Cilastatin inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein
CTD PMID:12712633 PMID:16316343 PMID:20435919 PMID:21497595 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CASP8 caspase 8 increases activity
increases expression
multiple interactions
EXP Cisplatin results in increased activity of CASP8 protein
Cisplatin results in increased expression of CASP8
Cilastatin inhibits the reaction [Cisplatin results in increased activity of CASP8 protein]
CTD PMID:12712633 PMID:20435919 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,470
JBrowse link
G CASP9 caspase 9 increases expression
increases activity
EXP Cisplatin results in increased expression of CASP9
Cisplatin results in increased activity of CASP9 protein
CTD PMID:12712633 PMID:20435919 NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,515...74,730,092
JBrowse link
G CYCS cytochrome c, somatic affects localization
multiple interactions
EXP Cisplatin affects the localization of CYCS protein
Bezafibrate inhibits the reaction [Cisplatin affects the localization of CYCS protein]
CTD PMID:16316343 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
JBrowse link
G EPO erythropoietin multiple interactions EXP [Cisplatin co-treated with EPO protein] results in increased cleavage of CASP3 protein CTD PMID:21497595 NCBI chr 3:8,620,508...8,622,936
Ensembl chr 3:8,620,508...8,622,936
JBrowse link
G FAS Fas cell surface death receptor increases expression EXP Cisplatin results in increased expression of FAS mRNA CTD PMID:20435919 NCBI chr14:100,927,305...100,954,781 JBrowse link
G FASLG Fas ligand multiple interactions
affects localization
EXP Cilastatin inhibits the reaction [Cisplatin affects the localization of FASLG protein] CTD PMID:20435919 NCBI chr 9:115,068,314...115,075,147
Ensembl chr 9:115,068,090...115,076,475
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [sulforaphane inhibits the reaction [Cisplatin results in decreased activity of GCLC protein]]; sulforaphane inhibits the reaction [Cisplatin results in decreased activity of GCLC protein] CTD PMID:20732396 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,564...27,253,535
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [Cisplatin results in increased expression of MYC] CTD PMID:12712633 NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,119...12,461,078
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP Dicumarol inhibits the reaction [sulforaphane inhibits the reaction [Cisplatin results in decreased activity of NQO1 protein]]; sulforaphane inhibits the reaction [Cisplatin results in decreased activity of NQO1 protein] CTD PMID:20732396 NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,769...17,302,590
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases activity
multiple interactions
EXP Cisplatin results in increased activity of PARP1 protein
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Cisplatin results in increased activity of PARP1 protein]
CTD PMID:25806124 NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,159...14,241,197
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha decreases activity
multiple interactions
EXP Cisplatin results in decreased activity of PPARA protein
[Cisplatin results in decreased activity of PPARA protein] which results in increased abundance of Fatty Acids, Nonesterified; Bezafibrate inhibits the reaction [[Cisplatin results in decreased activity of PPARA protein] which results in increased abundance of Fatty Acids, Nonesterified]; Bezafibrate inhibits the reaction [Cisplatin results in decreased activity of PPARA protein]
CTD PMID:16316343 NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,708...3,366,361
JBrowse link
G TNF tumor necrosis factor increases expression EXP Cisplatin results in increased expression of TNF mRNA CTD PMID:20435919 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
G TP53 tumor protein p53 increases expression
multiple interactions
EXP Cisplatin results in increased expression of TP53
mangostin inhibits the reaction [Cisplatin results in increased expression of TP53]
CTD PMID:12712633 PMID:20603111 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,643...52,953,819
JBrowse link
cobalt atom term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GNRH1 gonadotropin releasing hormone 1 multiple interactions
affects binding
EXP [Cobalt binds to GNRH1 protein] which results in increased abundance of Cyclic AMP; [Cobalt binds to GNRH1 protein] which results in increased secretion of LHB protein CTD PMID:15833593 NCBI chr14:9,442,971...9,447,521
Ensembl chr14:9,442,971...9,447,521
JBrowse link
G LHB luteinizing hormone subunit beta multiple interactions EXP [Cobalt binds to GNRH1 protein] which results in increased secretion of LHB protein CTD PMID:15833593 NCBI chr 6:54,263,574...54,269,286 JBrowse link
G LTA4H leukotriene A4 hydrolase increases activity EXP Cobalt results in increased activity of LTA4H protein CTD PMID:21670530 NCBI chr 5:87,486,552...87,518,520
Ensembl chr 5:87,486,512...87,518,515
JBrowse link
cobalt dichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AOC1 amine oxidase copper containing 1 affects binding EXP cobaltous chloride binds to AOC1 protein CTD PMID:16842785 NCBI chr18:6,309,583...6,321,016
Ensembl chr18:6,306,835...6,320,974
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 increases expression EXP cobaltous chloride results in increased expression of HSP90B1 mRNA CTD PMID:17464326 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,507...80,531,005
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP cobaltous chloride results in increased expression of HSPA5 mRNA CTD PMID:17464326 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
copper atom term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP7B ATPase copper transporting beta affects binding
multiple interactions
EXP Copper binds to ATP7B protein
Cholera Toxin inhibits the reaction [Copper binds to ATP7B protein]; Colforsin inhibits the reaction [Copper binds to ATP7B protein]; Cyclic AMP inhibits the reaction [Copper binds to ATP7B protein]; PRKACA protein inhibits the reaction [Copper binds to ATP7B protein]
CTD PMID:21084060 NCBI chr11:15,892,549...15,942,070 JBrowse link
G GNRH1 gonadotropin releasing hormone 1 affects binding
multiple interactions
EXP Copper binds to GNRH1 protein
[Copper binds to GNRH1 protein] which results in increased secretion of LHB protein
CTD PMID:16892001 NCBI chr14:9,442,971...9,447,521
Ensembl chr14:9,442,971...9,447,521
JBrowse link
G IGF1 insulin like growth factor 1 increases expression EXP Copper results in increased expression of IGF1 mRNA CTD PMID:22367704 NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,037
JBrowse link
G LHB luteinizing hormone subunit beta multiple interactions EXP [Copper binds to GNRH1 protein] which results in increased secretion of LHB protein CTD PMID:16892001 NCBI chr 6:54,263,574...54,269,286 JBrowse link
G PRKACA protein kinase cAMP-activated catalytic subunit alpha multiple interactions EXP PRKACA protein inhibits the reaction [Copper binds to ATP7B protein] CTD PMID:21084060 NCBI chr 2:65,074,876...65,095,564
Ensembl chr 2:65,074,870...65,095,553
JBrowse link
copper(0) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP7B ATPase copper transporting beta multiple interactions
affects binding
EXP Cholera Toxin inhibits the reaction [Copper binds to ATP7B protein]; Colforsin inhibits the reaction [Copper binds to ATP7B protein]; Cyclic AMP inhibits the reaction [Copper binds to ATP7B protein]; PRKACA protein inhibits the reaction [Copper binds to ATP7B protein] CTD PMID:21084060 NCBI chr11:15,892,549...15,942,070 JBrowse link
G GNRH1 gonadotropin releasing hormone 1 affects binding
multiple interactions
EXP Copper binds to GNRH1 protein
[Copper binds to GNRH1 protein] which results in increased secretion of LHB protein
CTD PMID:16892001 NCBI chr14:9,442,971...9,447,521
Ensembl chr14:9,442,971...9,447,521
JBrowse link
G IGF1 insulin like growth factor 1 increases expression EXP Copper results in increased expression of IGF1 mRNA CTD PMID:22367704 NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,037
JBrowse link
G LHB luteinizing hormone subunit beta multiple interactions EXP [Copper binds to GNRH1 protein] which results in increased secretion of LHB protein CTD PMID:16892001 NCBI chr 6:54,263,574...54,269,286 JBrowse link
G PRKACA protein kinase cAMP-activated catalytic subunit alpha multiple interactions EXP PRKACA protein inhibits the reaction [Copper binds to ATP7B protein] CTD PMID:21084060 NCBI chr 2:65,074,876...65,095,564
Ensembl chr 2:65,074,870...65,095,553
JBrowse link
copper(II) chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AOC1 amine oxidase copper containing 1 increases activity EXP cupric chloride results in increased activity of AOC1 protein CTD PMID:16842785 NCBI chr18:6,309,583...6,321,016
Ensembl chr18:6,306,835...6,320,974
JBrowse link
copper(II) sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATOX1 antioxidant 1 copper chaperone increases expression EXP Copper Sulfate results in increased expression of ATOX1 mRNA CTD PMID:22585802 NCBI chr16:71,299,321...71,314,598 JBrowse link
G CCNB1 cyclin B1 increases secretion EXP Copper Sulfate results in increased secretion of CCNB1 protein CTD PMID:24521407 NCBI chr16:47,338,239...47,348,385
Ensembl chr16:47,338,110...47,348,381
JBrowse link
G COX17 cytochrome c oxidase copper chaperone COX17 decreases expression EXP Copper Sulfate results in decreased expression of COX17 mRNA CTD PMID:22585802 NCBI chr13:140,584,286...140,594,636
Ensembl chr13:140,584,363...140,614,159
JBrowse link
G GHRH growth hormone releasing hormone increases expression EXP Copper Sulfate results in increased expression of GHRH mRNA CTD PMID:21110139 NCBI chr17:40,386,725...40,398,312
Ensembl chr17:40,387,344...40,397,857
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 increases expression EXP Copper Sulfate results in increased expression of HSP90B1 mRNA CTD PMID:17464326 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,507...80,531,005
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Copper Sulfate results in increased expression of HSPA5 mRNA CTD PMID:17464326 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
G IGF1 insulin like growth factor 1 increases secretion EXP Copper Sulfate results in increased secretion of IGF1 protein CTD PMID:24521407 NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,037
JBrowse link
G SST somatostatin decreases expression EXP Copper Sulfate results in decreased expression of SST mRNA; Copper Sulfate results in decreased expression of SST protein CTD PMID:21110139 NCBI chr13:125,337,560...125,338,742
Ensembl chr13:125,337,417...125,338,850
JBrowse link
cyanocob(III)alamin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase multiple interactions EXP [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] promotes the reaction [bisphenol A results in decreased expression of CAT protein]; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT mRNA; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT protein CTD PMID:29129240 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G DNMT1 DNA methyltransferase 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT1 mRNA CTD PMID:28445388 NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,564...69,029,919
JBrowse link
G DNMT3A DNA methyltransferase 3 alpha multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of DNMT3A mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT3A mRNA CTD PMID:28445388 NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,609,139
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions EXP [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of GPX1 mRNA; [bisphenol A co-treated with [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12]] results in increased expression of GPX1 mRNA CTD PMID:29129240 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,914,932...31,917,335
JBrowse link
G MTHFR methylenetetrahydrofolate reductase multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of MTHFR mRNA CTD PMID:28445388 NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,636...71,881,820
JBrowse link
G SI sucrase-isomaltase multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SI mRNA CTD PMID:28445388 NCBI chr13:104,296,281...104,379,558
Ensembl chr13:104,296,283...104,379,478
JBrowse link
G SLC15A1 solute carrier family 15 member 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of SLC15A1 mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased methylation of SLC15A1 promoter]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC15A1 mRNA CTD PMID:28445388 NCBI chr11:67,652,808...67,690,457
Ensembl chr11:67,652,193...67,710,933
JBrowse link
G SLC5A1 solute carrier family 5 member 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with bisphenol A] results in increased expression of SLC5A1 mRNA; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC5A1 mRNA CTD PMID:28445388 NCBI chr14:48,566,400...48,704,145
Ensembl chr14:48,566,343...48,705,841
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions EXP [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of SOD1 mRNA CTD PMID:29129240 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
ferroheme b term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HMOX1 heme oxygenase 1 increases metabolic processing
multiple interactions
EXP HMOX1 protein results in increased metabolism of Heme
[HMOX1 protein results in increased metabolism of Heme] which results in increased abundance of Carbon Monoxide; chromium mesoporphyrin inhibits the reaction [[HMOX1 protein results in increased metabolism of Heme] which results in increased abundance of Carbon Monoxide]; tin protoporphyrin IX inhibits the reaction [[HMOX1 protein results in increased metabolism of Heme] which results in increased abundance of Carbon Monoxide]
CTD PMID:16751286
heme b term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HMOX1 heme oxygenase 1 increases metabolic processing
multiple interactions
EXP HMOX1 protein results in increased metabolism of Heme
[HMOX1 protein results in increased metabolism of Heme] which results in increased abundance of Carbon Monoxide; chromium mesoporphyrin inhibits the reaction [[HMOX1 protein results in increased metabolism of Heme] which results in increased abundance of Carbon Monoxide]; tin protoporphyrin IX inhibits the reaction [[HMOX1 protein results in increased metabolism of Heme] which results in increased abundance of Carbon Monoxide]
CTD PMID:16751286
manganese atom term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FBP1 fructose-bisphosphatase 1 increases activity EXP Manganese results in increased activity of FBP1 protein CTD PMID:12595529 NCBI chr10:27,588,609...27,622,225
Ensembl chr10:27,588,582...27,623,077
JBrowse link
G OGDH oxoglutarate dehydrogenase multiple interactions EXP Manganese inhibits the reaction [Calcium results in increased activity of OGDH protein] CTD PMID:20800605 NCBI chr18:50,609,415...50,684,990
Ensembl chr18:50,609,418...50,684,964
JBrowse link
manganese(0) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FBP1 fructose-bisphosphatase 1 increases activity EXP Manganese results in increased activity of FBP1 protein CTD PMID:12595529 NCBI chr10:27,588,609...27,622,225
Ensembl chr10:27,588,582...27,623,077
JBrowse link
G OGDH oxoglutarate dehydrogenase multiple interactions EXP Manganese inhibits the reaction [Calcium results in increased activity of OGDH protein] CTD PMID:20800605 NCBI chr18:50,609,415...50,684,990
Ensembl chr18:50,609,418...50,684,964
JBrowse link
mercury atom term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF4 activating transcription factor 4 increases expression EXP Mercury results in increased expression of ATF4 protein CTD PMID:16759985 NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,738,880...8,745,225
JBrowse link
G EIF2A eukaryotic translation initiation factor 2A increases phosphorylation EXP Mercury results in increased phosphorylation of EIF2A protein CTD PMID:16759985 NCBI chr13:90,761,453...90,804,274
Ensembl chr13:90,761,465...90,804,276
JBrowse link
G FSHB follicle stimulating hormone subunit beta multiple interactions EXP [FSHB protein co-treated with Lead co-treated with Mercury] results in decreased secretion of Progesterone CTD PMID:20390873 NCBI chr 2:30,395,769...30,399,282
Ensembl chr 2:30,395,018...30,399,274
JBrowse link
G LDHA lactate dehydrogenase A multiple interactions EXP Mercury binds to and results in decreased folding of LDHA protein CTD PMID:18501191 NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,812,453...40,826,715
JBrowse link
mercury dichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AQP1 aquaporin 1 (Colton blood group) multiple interactions EXP Mercuric Chloride inhibits the reaction [AQP1 protein results in increased transport of Water] CTD PMID:16534851 NCBI chr18:42,063,482...42,076,741
Ensembl chr18:42,063,481...42,076,746
JBrowse link
G ATF4 activating transcription factor 4 increases expression EXP Mercuric Chloride results in increased expression of ATF4 protein CTD PMID:16759985 NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,738,880...8,745,225
JBrowse link
G EIF2A eukaryotic translation initiation factor 2A increases phosphorylation EXP Mercuric Chloride results in increased phosphorylation of EIF2A protein CTD PMID:16759985 NCBI chr13:90,761,453...90,804,274
Ensembl chr13:90,761,465...90,804,276
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP Dactinomycin inhibits the reaction [Mercuric Chloride results in increased expression of FOS mRNA]
Mercuric Chloride results in increased expression of FOS mRNA; Mercuric Chloride results in increased expression of FOS protein
CTD PMID:9463523 NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 increases expression EXP Mercuric Chloride results in increased expression of HSP90B1 mRNA CTD PMID:17464326 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,507...80,531,005
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Mercuric Chloride results in increased expression of HSPA5 mRNA CTD PMID:17464326 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases expression
increases phosphorylation
EXP Mercuric Chloride results in increased expression of JUN mRNA; Mercuric Chloride results in increased expression of JUN protein
Mercuric Chloride results in increased phosphorylation of JUN protein
CTD PMID:10696784 NCBI chr 6:153,686,425...153,687,635 JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases phosphorylation EXP Mercuric Chloride results in increased phosphorylation of MAPK8 protein CTD PMID:10696784 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,172,200
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 increases phosphorylation EXP Mercuric Chloride results in increased phosphorylation of MAPK9 protein CTD PMID:10696784 NCBI chr 2:78,338,466...78,399,108
Ensembl chr 2:78,338,369...78,399,105
JBrowse link
mercury(0) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF4 activating transcription factor 4 increases expression EXP Mercury results in increased expression of ATF4 protein CTD PMID:16759985 NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,738,880...8,745,225
JBrowse link
G EIF2A eukaryotic translation initiation factor 2A increases phosphorylation EXP Mercury results in increased phosphorylation of EIF2A protein CTD PMID:16759985 NCBI chr13:90,761,453...90,804,274
Ensembl chr13:90,761,465...90,804,276
JBrowse link
G FSHB follicle stimulating hormone subunit beta multiple interactions EXP [FSHB protein co-treated with Lead co-treated with Mercury] results in decreased secretion of Progesterone CTD PMID:20390873 NCBI chr 2:30,395,769...30,399,282
Ensembl chr 2:30,395,018...30,399,274
JBrowse link
G LDHA lactate dehydrogenase A multiple interactions EXP Mercury binds to and results in decreased folding of LDHA protein CTD PMID:18501191 NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,812,453...40,826,715
JBrowse link
nickel atom term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GNRH1 gonadotropin releasing hormone 1 affects binding
multiple interactions
EXP Nickel binds to GNRH1 protein
[Nickel binds to GNRH1 protein] which results in increased secretion of LHB protein
CTD PMID:16892001 NCBI chr14:9,442,971...9,447,521
Ensembl chr14:9,442,971...9,447,521
JBrowse link
G LHB luteinizing hormone subunit beta multiple interactions EXP [Nickel binds to GNRH1 protein] which results in increased secretion of LHB protein CTD PMID:16892001 NCBI chr 6:54,263,574...54,269,286 JBrowse link
potassium chromate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GAPDH glyceraldehyde-3-phosphate dehydrogenase decreases activity EXP potassium chromate(VI) results in decreased activity of GAPDH protein CTD PMID:26582256 NCBI chr 5:64,129,678...64,135,194
Ensembl chr 5:64,129,680...64,133,991
JBrowse link
potassium hexacyanoferrate(3-) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 decreases activity EXP potassium ferricyanide results in decreased activity of NOS3 protein CTD PMID:8810647 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,156...6,228,938
JBrowse link
ruthenium red term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TRPV1 transient receptor potential cation channel subfamily V member 1 multiple interactions EXP Ruthenium Red inhibits the reaction [Sodium affects the reaction [TRPV1 protein results in increased abundance of Calcium]] CTD PMID:18230619 NCBI chr12:49,676,536...49,709,634
Ensembl chr12:49,677,291...49,701,325
JBrowse link
sodium dichromate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 decreases expression EXP sodium bichromate results in decreased expression of AKT1 protein CTD PMID:12760830
titanium dioxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 increases phosphorylation EXP titanium dioxide results in increased phosphorylation of AKT1 protein CTD PMID:23380242
G CCL2 chemokine (C-C motif) ligand 2 multiple interactions
increases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [titanium dioxide results in increased expression of CCL2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [titanium dioxide results in increased expression of CCL2 mRNA]; acetovanillone inhibits the reaction [titanium dioxide results in increased expression of CCL2 mRNA]; epigallocatechin gallate inhibits the reaction [titanium dioxide results in increased expression of CCL2 mRNA]; prolinedithiocarbamate inhibits the reaction [titanium dioxide results in increased expression of CCL2 mRNA]; pyrazolanthrone inhibits the reaction [titanium dioxide results in increased expression of CCL2 mRNA]; SB 203580 inhibits the reaction [titanium dioxide results in increased expression of CCL2 mRNA] CTD PMID:23380242 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,028
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation EXP titanium dioxide results in increased phosphorylation of MAPK1 protein CTD PMID:23380242 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation EXP titanium dioxide results in increased phosphorylation of MAPK3 protein CTD PMID:23380242 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G NFKBIA NFKB inhibitor alpha increases phosphorylation EXP titanium dioxide results in increased phosphorylation of NFKBIA protein CTD PMID:23380242 NCBI chr 7:64,508,119...64,510,754
Ensembl chr 7:64,508,016...64,558,057
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 increases expression
multiple interactions
EXP titanium dioxide results in increased expression of VCAM1 mRNA; titanium dioxide results in increased expression of VCAM1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [titanium dioxide results in increased expression of VCAM1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [titanium dioxide results in increased expression of VCAM1 mRNA]; acetovanillone inhibits the reaction [titanium dioxide results in increased expression of VCAM1 mRNA]; epigallocatechin gallate inhibits the reaction [titanium dioxide results in increased expression of VCAM1 mRNA]; prolinedithiocarbamate inhibits the reaction [titanium dioxide results in increased expression of VCAM1 mRNA]; pyrazolanthrone inhibits the reaction [titanium dioxide results in increased expression of VCAM1 mRNA]; SB 203580 inhibits the reaction [titanium dioxide results in increased expression of VCAM1 mRNA]
CTD PMID:23380242 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,908...117,511,226
JBrowse link
tris(picolinato)chromium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin decreases expression EXP chromium tripicolinate results in decreased expression of INS protein CTD PMID:7628956 NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841
JBrowse link
zinc acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA5 annexin A5 multiple interactions EXP Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of ANXA5 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of ANXA5 protein]]] CTD PMID:10617950 NCBI chr 8:102,387,833...102,420,868
Ensembl chr 8:102,388,103...102,425,750
JBrowse link
G CASP3 caspase 3 multiple interactions EXP Zinc Acetate inhibits the reaction [Linoleic Acid results in increased activity of CASP3 protein]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of CASP3 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased activity of CASP3 protein]]; Zinc Acetate promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]] CTD PMID:10617950 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions EXP Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of PPARA mRNA] CTD PMID:18845708 NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,708...3,366,361
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PTGS2 mRNA] CTD PMID:18845708 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,013...127,858,884
JBrowse link
G SELE selectin E multiple interactions EXP Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SELE mRNA] CTD PMID:18845708 NCBI chr 4:81,289,061...81,299,657 JBrowse link
G TNF tumor necrosis factor multiple interactions EXP Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of ANXA5 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of CASP3 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of ANXA5 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased activity of CASP3 protein]]; Zinc Acetate promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]] CTD PMID:10617950 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
zinc atom term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMY2 amylase, alpha 2B (pancreatic) increases activity EXP Zinc results in increased activity of AMY2B protein CTD PMID:17093223 NCBI chr 4:115,172,036...115,209,749 JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression EXP Zinc results in increased expression of BAX protein CTD PMID:11781163 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144
JBrowse link
G BCL2L1 BCL2 like 1 increases expression EXP Zinc results in increased expression of BCL2L1 protein CTD PMID:11781163 NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,141...35,415,359
JBrowse link
G CAT catalase multiple interactions EXP [Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in decreased expression of CAT mRNA] CTD PMID:32280687 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CPA1 carboxypeptidase A1 increases activity EXP Zinc results in increased activity of CPA1 protein CTD PMID:17093223 NCBI chr18:18,466,564...18,482,099
Ensembl chr18:18,461,721...18,598,032
JBrowse link
G FBP1 fructose-bisphosphatase 1 increases activity EXP Zinc results in increased activity of FBP1 protein CTD PMID:12595529 NCBI chr10:27,588,609...27,622,225
Ensembl chr10:27,588,582...27,623,077
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions EXP [Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in decreased expression of GPX1 mRNA] CTD PMID:32280687 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,914,932...31,917,335
JBrowse link
G IGF1 insulin like growth factor 1 increases expression EXP Zinc results in increased expression of IGF1 protein CTD PMID:15387849 NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,037
JBrowse link
G IL6 interleukin 6 multiple interactions EXP [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of IL6 protein] CTD PMID:14519784 PMID:15226458 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G LOC100302368 trypsinogen increases activity EXP Zinc results in increased activity of PRSS1 protein CTD PMID:17093223 NCBI chr18:7,653,537...7,696,820 JBrowse link
G LOC110258578 interleukin-1 beta-like multiple interactions EXP [Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in increased expression of IL1B mRNA] CTD PMID:32280687
G LTA4H leukotriene A4 hydrolase decreases activity EXP Zinc results in decreased activity of LTA4H protein CTD PMID:21670530 NCBI chr 5:87,486,552...87,518,520
Ensembl chr 5:87,486,512...87,518,515
JBrowse link
G MT3 metallothionein 3 multiple interactions EXP MT3 protein binds to and affects the abundance of Zinc CTD PMID:12405537 NCBI chr 6:18,634,735...18,636,134
Ensembl chr 6:18,634,721...18,789,137
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP [Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in decreased expression of NFE2L2 mRNA] CTD PMID:32280687 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma increases expression
multiple interactions
EXP Zinc results in increased expression of PPARG mRNA
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased expression of and results in increased activity of PPARG protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased expression of PPARG mRNA]; Zinc results in increased expression of and results in increased activity of PPARG protein
CTD PMID:14519784 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,655...68,433,947
JBrowse link
G PSP-I porcine seminal protein I affects folding
multiple interactions
EXP Zinc affects the folding of PSP-I protein
Zinc promotes the reaction [PSP-I protein binds to Heparin]
CTD PMID:16819821 NCBI chr14:132,302,376...132,309,388
Ensembl chr14:132,274,241...132,320,855
JBrowse link
G SLC30A1 solute carrier family 30 member 1 increases expression EXP Zinc results in increased expression of SLC30A1 mRNA; Zinc results in increased expression of SLC30A1 protein CTD PMID:18061429 NCBI chr 9:131,633,586...131,636,934
Ensembl chr 9:131,633,585...131,640,675
JBrowse link
G SLC30A2 solute carrier family 30 member 2 increases expression EXP Zinc results in increased expression of SLC30A2 protein CTD PMID:18061429 NCBI chr 6:83,478,761...83,484,876
Ensembl chr 6:83,477,759...83,484,688
JBrowse link
G SLC39A10 solute carrier family 39 member 10 increases expression
decreases expression
EXP Zinc results in increased expression of SLC39A10 mRNA
Zinc results in decreased expression of SLC39A10 mRNA
CTD PMID:16804107 NCBI chr15:99,584,830...99,724,621
Ensembl chr15:99,584,839...99,726,404
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions EXP [Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in decreased expression of SOD1 mRNA] CTD PMID:32280687 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP [2,4-thiazolidinedione co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [ciprofibrate co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [Fenofibrate co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [Troglitazone co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in increased expression of TNF mRNA]; [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]]; [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA]] CTD PMID:15226458 PMID:32280687 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions EXP [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA]] CTD PMID:15226458 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,908...117,511,226
JBrowse link
zinc dichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PSP-I porcine seminal protein I multiple interactions
affects folding
EXP zinc chloride promotes the reaction [PSP-I protein binds to Heparin]
zinc chloride affects the folding of PSP-I protein
CTD PMID:16819821 NCBI chr14:132,302,376...132,309,388
Ensembl chr14:132,274,241...132,320,855
JBrowse link
zinc oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMY2 amylase, alpha 2B (pancreatic) increases activity EXP Zinc Oxide results in increased activity of AMY2B protein CTD PMID:17093223 NCBI chr 4:115,172,036...115,209,749 JBrowse link
G CPA1 carboxypeptidase A1 increases activity EXP Zinc Oxide results in increased activity of CPA1 protein CTD PMID:17093223 NCBI chr18:18,466,564...18,482,099
Ensembl chr18:18,461,721...18,598,032
JBrowse link
G IGF1 insulin like growth factor 1 increases expression EXP Zinc Oxide results in increased expression of IGF1 mRNA CTD PMID:7899834 NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,037
JBrowse link
G LOC100302368 trypsinogen increases activity EXP Zinc Oxide results in increased activity of PRSS1 protein CTD PMID:17093223 NCBI chr18:7,653,537...7,696,820 JBrowse link
zinc protoporphyrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 multiple interactions EXP zinc protoporphyrin inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1B1 protein] CTD PMID:19466990 NCBI chr 8:44,544,364...44,604,690
Ensembl chr 8:44,544,179...44,604,704
JBrowse link
zinc sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP Zinc Sulfate results in increased expression of BAX mRNA
3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of BAX mRNA]
CTD PMID:28803810 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144
JBrowse link
G BECN1 beclin 1 increases expression
multiple interactions
EXP Zinc Sulfate results in increased expression of BECN1 protein
3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of BECN1 protein]
CTD PMID:28803810 NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373
JBrowse link
G CASP3 caspase 3 multiple interactions
increases expression
increases cleavage
EXP 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased cleavage of CASP3 protein]
Zinc Sulfate results in increased expression of CASP3 mRNA
CTD PMID:28803810 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CASP6 caspase 6 increases expression EXP Zinc Sulfate results in increased expression of CASP6 mRNA CTD PMID:28803810 NCBI chr 8:112,519,450...112,534,315
Ensembl chr 8:112,483,392...112,540,550
JBrowse link
G CASP8 caspase 8 multiple interactions
increases cleavage
EXP 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased cleavage of CASP8 protein] CTD PMID:28803810 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,470
JBrowse link
G CYCS cytochrome c, somatic increases expression
multiple interactions
EXP Zinc Sulfate results in increased expression of CYCS mRNA
3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of CYCS mRNA]
CTD PMID:28803810 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions EXP Zinc Sulfate inhibits the reaction [Diquat results in decreased expression of GPX1 mRNA] CTD PMID:32280687 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,914,932...31,917,335
JBrowse link
G HSPA6 heat shock protein family A (Hsp70) member 6 increases expression EXP Zinc Sulfate results in increased expression of HSP70 mRNA CTD PMID:23274768 NCBI chr 4:88,970,592...88,973,109
Ensembl chr 4:88,970,591...88,985,586
JBrowse link
G LOC110258578 interleukin-1 beta-like multiple interactions EXP Zinc Sulfate inhibits the reaction [Diquat results in increased expression of IL1B mRNA] CTD PMID:32280687
G MAP1LC3A microtubule associated protein 1 light chain 3 alpha increases expression EXP Zinc Sulfate results in increased expression of MAP1LC3A mRNA CTD PMID:28803810 NCBI chr17:37,957,830...37,959,505
Ensembl chr17:37,957,507...37,959,505
JBrowse link
G MT1A metallothionein 1A increases expression EXP Zinc Sulfate results in increased expression of MT1A mRNA CTD PMID:25895165 NCBI chr 6:18,672,016...18,673,673
Ensembl chr 6:18,660,642...18,673,766
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Zinc Sulfate inhibits the reaction [Diquat results in decreased expression of NFE2L2 mRNA] CTD PMID:32280687 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
G SLC30A1 solute carrier family 30 member 1 increases expression EXP Zinc Sulfate results in increased expression of SLC30A1 mRNA CTD PMID:25895165 NCBI chr 9:131,633,586...131,636,934
Ensembl chr 9:131,633,585...131,640,675
JBrowse link
G SLC39A10 solute carrier family 39 member 10 decreases expression
increases expression
EXP Zinc Sulfate results in decreased expression of SLC39A10 mRNA
Zinc Sulfate results in increased expression of SLC39A10 mRNA
CTD PMID:16804107 NCBI chr15:99,584,830...99,724,621
Ensembl chr15:99,584,839...99,726,404
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions EXP Zinc Sulfate inhibits the reaction [Diquat results in decreased expression of SOD1 mRNA] CTD PMID:32280687 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
G SQSTM1 sequestosome 1 increases expression
multiple interactions
decreases expression
EXP Zinc Sulfate results in increased expression of SQSTM1 mRNA
3-methyladenine inhibits the reaction [Zinc Sulfate results in decreased expression of SQSTM1 protein]
CTD PMID:28803810 NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,768...78,784,256
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP Zinc Sulfate inhibits the reaction [Diquat results in increased expression of TNF mRNA] CTD PMID:32280687 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
zinc(0) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMY2 amylase, alpha 2B (pancreatic) increases activity EXP Zinc results in increased activity of AMY2B protein CTD PMID:17093223 NCBI chr 4:115,172,036...115,209,749 JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression EXP Zinc results in increased expression of BAX protein CTD PMID:11781163 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144
JBrowse link
G BCL2L1 BCL2 like 1 increases expression EXP Zinc results in increased expression of BCL2L1 protein CTD PMID:11781163 NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,141...35,415,359
JBrowse link
G CAT catalase multiple interactions EXP [Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in decreased expression of CAT mRNA] CTD PMID:32280687 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CPA1 carboxypeptidase A1 increases activity EXP Zinc results in increased activity of CPA1 protein CTD PMID:17093223 NCBI chr18:18,466,564...18,482,099
Ensembl chr18:18,461,721...18,598,032
JBrowse link
G FBP1 fructose-bisphosphatase 1 increases activity EXP Zinc results in increased activity of FBP1 protein CTD PMID:12595529 NCBI chr10:27,588,609...27,622,225
Ensembl chr10:27,588,582...27,623,077
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions EXP [Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in decreased expression of GPX1 mRNA] CTD PMID:32280687 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,914,932...31,917,335
JBrowse link
G IGF1 insulin like growth factor 1 increases expression EXP Zinc results in increased expression of IGF1 protein CTD PMID:15387849 NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,037
JBrowse link
G IL6 interleukin 6 multiple interactions EXP [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of IL6 protein] CTD PMID:14519784 PMID:15226458 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G LOC100302368 trypsinogen increases activity EXP Zinc results in increased activity of PRSS1 protein CTD PMID:17093223 NCBI chr18:7,653,537...7,696,820 JBrowse link
G LOC110258578 interleukin-1 beta-like multiple interactions EXP [Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in increased expression of IL1B mRNA] CTD PMID:32280687
G LTA4H leukotriene A4 hydrolase decreases activity EXP Zinc results in decreased activity of LTA4H protein CTD PMID:21670530 NCBI chr 5:87,486,552...87,518,520
Ensembl chr 5:87,486,512...87,518,515
JBrowse link
G MT3 metallothionein 3 multiple interactions EXP MT3 protein binds to and affects the abundance of Zinc CTD PMID:12405537 NCBI chr 6:18,634,735...18,636,134
Ensembl chr 6:18,634,721...18,789,137
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP [Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in decreased expression of NFE2L2 mRNA] CTD PMID:32280687 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions
increases expression
EXP N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased expression of and results in increased activity of PPARG protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased expression of PPARG mRNA]; Zinc results in increased expression of and results in increased activity of PPARG protein CTD PMID:14519784 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,655...68,433,947
JBrowse link
G PSP-I porcine seminal protein I multiple interactions
affects folding
EXP Zinc promotes the reaction [PSP-I protein binds to Heparin]
Zinc affects the folding of PSP-I protein
CTD PMID:16819821 NCBI chr14:132,302,376...132,309,388
Ensembl chr14:132,274,241...132,320,855
JBrowse link
G SLC30A1 solute carrier family 30 member 1 increases expression EXP Zinc results in increased expression of SLC30A1 mRNA; Zinc results in increased expression of SLC30A1 protein CTD PMID:18061429 NCBI chr 9:131,633,586...131,636,934
Ensembl chr 9:131,633,585...131,640,675
JBrowse link
G SLC30A2 solute carrier family 30 member 2 increases expression EXP Zinc results in increased expression of SLC30A2 protein CTD PMID:18061429 NCBI chr 6:83,478,761...83,484,876
Ensembl chr 6:83,477,759...83,484,688
JBrowse link
G SLC39A10 solute carrier family 39 member 10 increases expression
decreases expression
EXP Zinc results in increased expression of SLC39A10 mRNA
Zinc results in decreased expression of SLC39A10 mRNA
CTD PMID:16804107 NCBI chr15:99,584,830...99,724,621
Ensembl chr15:99,584,839...99,726,404
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions EXP [Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in decreased expression of SOD1 mRNA] CTD PMID:32280687 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP [2,4-thiazolidinedione co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [ciprofibrate co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [Fenofibrate co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [Troglitazone co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in increased expression of TNF mRNA]; [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]]; [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA]] CTD PMID:15226458 PMID:32280687 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions EXP [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA]] CTD PMID:15226458 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,908...117,511,226
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 1030
    chemical entity 1030
      atom 1015
        metal atom 235
          transition element atom 197
            chromium group element atom + 3
            cobalt group element atom + 15
            copper group element atom + 13
            d-block element atom + 197
            f-block element atom + 0
            iron group element atom + 3
            manganese group element atom + 2
            nickel group element atom + 20
            platinum group metal atom + 19
            rare earth metal atom + 0
            scandium group element atom + 0
            titanium group element atom + 6
            transition element molecular entity + 195
            vanadium group element atom + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 1030
    subatomic particle 1015
      composite particle 1015
        hadron 1015
          baryon 1015
            nucleon 1015
              atomic nucleus 1015
                atom 1015
                  metal atom 235
                    transition element atom 197
                      chromium group element atom + 3
                      cobalt group element atom + 15
                      copper group element atom + 13
                      d-block element atom + 197
                      f-block element atom + 0
                      iron group element atom + 3
                      manganese group element atom + 2
                      nickel group element atom + 20
                      platinum group metal atom + 19
                      rare earth metal atom + 0
                      scandium group element atom + 0
                      titanium group element atom + 6
                      transition element molecular entity + 195
                      vanadium group element atom + 0
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