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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:anastrozole
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Accession:CHEBI:2704 term browser browse the term
Definition:A 1,2,4-triazole compound having a 3,5-bis(2-cyano-2-propyl)benzyl group at the 1-position.
Synonyms:exact_synonym: 2,2'-[5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]bis(2-methylpropanenitrile)
 related_synonym: Anastrozol;   Formula=C17H19N5;   InChI=1S/C17H19N5/c1-16(2,9-18)14-5-13(8-22-12-20-11-21-22)6-15(7-14)17(3,4)10-19/h5-7,11-12H,8H2,1-4H3;   InChIKey=YBBLVLTVTVSKRW-UHFFFAOYSA-N;   SMILES=CC(C)(C#N)c1cc(Cn2cncn2)cc(c1)C(C)(C)C#N;   alpha,alpha,alpha',alpha'-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-m-benzenediacetonitrile
 xref: Beilstein:8005958;   CAS:120511-73-1;   DrugBank:DB01217;   Drug_Central:210;   KEGG:C08159;   KEGG:D00960;   LINCS:LSM-5631
 xref_mesh: MESH:C090450
 xref: Patent:EP296749;   Patent:US4935437;   Wikipedia:Anastrozole


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anastrozole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cycs cytochrome c, somatic multiple interactions ISO [Oleic Acid co-treated with anastrozole] affects the localization of CYCS protein; [Olive Oil co-treated with anastrozole] affects the localization of CYCS protein CTD PMID:24161488 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Anastrozole results in decreased activity of CYP19A1 protein CTD PMID:15837728 PMID:16001952 PMID:16023338 PMID:16023854 PMID:16034487 PMID:16054421 PMID:21341743 PMID:32764486 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Fshb follicle stimulating hormone subunit beta increases expression EXP anastrozole results in increased expression of FSHB protein CTD PMID:10657858 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression ISO anastrozole results in decreased expression of GJA1 protein CTD PMID:29180066 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP anastrozole results in increased expression of LHB protein CTD PMID:10657858 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions
decreases expression
ISO [Tamoxifen co-treated with anastrozole] results in decreased expression of MKI67 protein
anastrozole results in decreased expression of MKI67 protein
CTD PMID:15767642 PMID:16002280 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Pgr progesterone receptor decreases expression ISO anastrozole results in decreased expression of PGR protein CTD PMID:16002280 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO anastrozole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    chemical entity 19771
      group 19689
        pseudohalo group 2943
          cyano group 2943
            nitrile 2943
              anastrozole 8
                1-\{[3,5-bis(1-cyano-1-methylethyl)phenyl]methyl\}-4-[(3S,4R,5R,6R)-6-carboxy-3,4,5-trihydroxyoxan-2-yl]-1,2,4lambda5-triazol-4-ylium 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic molecule 19497
                              organic cyclic compound 19321
                                organic heterocyclic compound 18512
                                  heteroarene 16520
                                    monocyclic heteroarene 13364
                                      azole 12538
                                        triazoles 3652
                                          anastrozole 8
                                            1-\{[3,5-bis(1-cyano-1-methylethyl)phenyl]methyl\}-4-[(3S,4R,5R,6R)-6-carboxy-3,4,5-trihydroxyoxan-2-yl]-1,2,4lambda5-triazol-4-ylium 0
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