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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:thiophenes
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Accession:CHEBI:26961 term browser browse the term
Definition:Compounds containing at least one thiophene ring.
Synonyms:alt_id: MESH:D013876
 xref_mesh: MESH:D013876


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thiophenes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abce1 ATP binding cassette subfamily E member 1 multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of ABCE1 mRNA] CTD PMID:16140955 NCBI chr19:31,867,960...31,892,863
Ensembl chr19:31,867,981...31,892,863
JBrowse link
G Anxa1 annexin A1 multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in increased expression of ANXA1 mRNA] CTD PMID:16140955 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in increased expression of BIRC2 mRNA] CTD PMID:16140955 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO Thiophenes analog results in decreased activity of CA1 protein CTD PMID:30537031 NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479
JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Thiophenes analog results in decreased activity of CA2 protein CTD PMID:30537031 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Cd53 Cd53 molecule multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in increased expression of CD53 mRNA] CTD PMID:16140955 NCBI chr 2:209,489,279...209,537,098
Ensembl chr 2:209,489,279...209,537,087
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in increased expression of CDKN1A protein] CTD PMID:16140954 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in increased expression of CDKN1B protein] CTD PMID:16140954 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cse1l chromosome segregation 1 like multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of CSE1L mRNA] CTD PMID:16140955 NCBI chr 3:163,664,074...163,702,074
Ensembl chr 3:163,664,136...163,702,060
JBrowse link
G Ddx10 DEAD-box helicase 10 multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of DDX10 mRNA] CTD PMID:16140955 NCBI chr 8:57,667,472...57,830,504
Ensembl chr 8:57,667,472...57,830,504
JBrowse link
G Ddx18 DEAD-box helicase 18 multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of DDX18 mRNA] CTD PMID:16140955 NCBI chr13:37,522,558...37,536,066
Ensembl chr13:37,522,561...37,536,066
JBrowse link
G Ddx58 DEXD/H-box helicase 58 multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in increased expression of DDX58 mRNA] CTD PMID:16140955 NCBI chr 5:56,486,584...56,536,898
Ensembl chr 5:56,500,734...56,536,772
JBrowse link
G Eif3b eukaryotic translation initiation factor 3, subunit B multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of EIF3B mRNA] CTD PMID:16140955 NCBI chr12:16,285,730...16,310,190
Ensembl chr12:16,285,733...16,310,190
JBrowse link
G Eif3c eukaryotic translation initiation factor 3, subunit C multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of EIF3C mRNA] CTD PMID:16140955 NCBI chr 1:197,964,406...197,982,917
Ensembl chr 1:197,964,407...197,982,601
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of EIF4E mRNA] CTD PMID:16140955 NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of EIF4EBP1 mRNA] CTD PMID:16140955 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Gas7 growth arrest specific 7 multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in increased expression of GAS7 mRNA] CTD PMID:16140955 NCBI chr10:54,010,723...54,240,805
Ensembl chr10:54,126,486...54,236,476
JBrowse link
G Grb10 growth factor receptor bound protein 10 multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of GRB10 mRNA] CTD PMID:16140955 NCBI chr14:92,021,851...92,122,249
Ensembl chr14:92,021,851...92,117,923
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in increased expression of GSTP1 mRNA] CTD PMID:16140955 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hdac1 histone deacetylase 1 multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in increased expression of HDAC1 mRNA] CTD PMID:16140955 NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723
JBrowse link
G Hrh3 histamine receptor H3 multiple interactions ISO Thiophenes analog binds to and results in decreased activity of HRH3 protein CTD PMID:16616493 NCBI chr 3:175,474,310...175,479,395
Ensembl chr 3:175,473,078...175,479,395
JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in increased expression of IFIT3 mRNA] CTD PMID:16140954 NCBI chr 1:252,906,234...252,911,377
Ensembl chr 1:252,906,234...252,911,382
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Thiophenes inhibits the reaction [KEAP1 gene mutant form promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]] CTD PMID:23906629 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itga6 integrin subunit alpha 6 multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in increased expression of ITGA6 mRNA] CTD PMID:16140955 NCBI chr 3:58,442,904...58,515,124
Ensembl chr 3:58,443,101...58,515,124
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO Thiophenes inhibits the reaction [KEAP1 gene mutant form promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]] CTD PMID:23906629 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in increased expression of LAMP2 mRNA] CTD PMID:16140955 NCBI chr  X:124,722,628...124,766,079
Ensembl chr  X:124,722,628...124,766,044
JBrowse link
G Ly6e lymphocyte antigen 6 family member E multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in increased expression of LY6E mRNA] CTD PMID:16140954 NCBI chr 7:116,355,426...116,359,862
Ensembl chr 7:116,355,698...116,359,862
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of MPO mRNA] CTD PMID:16140954 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of MYC mRNA] CTD PMID:16140955 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myh9 myosin, heavy chain 9 multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in increased expression of MYH9 mRNA] CTD PMID:16140955 NCBI chr 7:118,740,005...118,792,507
Ensembl chr 7:118,741,110...118,792,625
JBrowse link
G Nae1 NEDD8 activating enzyme E1 subunit 1 multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of NAE1 mRNA] CTD PMID:16140955 NCBI chr19:653,510...680,378
Ensembl chr19:653,510...680,378
JBrowse link
G Nmi N-myc (and STAT) interactor multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in increased expression of NMI mRNA] CTD PMID:16140955 NCBI chr 3:37,458,891...37,480,984
Ensembl chr 3:37,458,890...37,480,984
JBrowse link
G Ppm1g protein phosphatase, Mg2+/Mn2+ dependent, 1G multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of PPM1G mRNA] CTD PMID:16140955 NCBI chr 6:26,517,840...26,537,292
Ensembl chr 6:26,517,840...26,537,290
JBrowse link
G Prmt1 protein arginine methyltransferase 1 multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of PRMT1 mRNA] CTD PMID:16140955 NCBI chr 1:100,971,132...100,980,411
Ensembl chr 1:100,971,273...100,980,340
JBrowse link
G Rabggtb Rab geranylgeranyltransferase subunit beta multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of RABGGTB mRNA] CTD PMID:16140955 NCBI chr 2:260,110,309...260,115,574
Ensembl chr 2:260,110,309...260,115,577
JBrowse link
G Rara retinoic acid receptor, alpha multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in increased expression of RARA mRNA alternative form] CTD PMID:16140955 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in decreased phosphorylation of RB1 protein] CTD PMID:16140954 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Ruvbl2 RuvB-like AAA ATPase 2 multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of RUVBL2 mRNA] CTD PMID:16140955 NCBI chr 1:101,413,766...101,426,970
Ensembl chr 1:101,413,766...101,426,852
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in increased expression of STAT1 mRNA] CTD PMID:16140955 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stk10 serine/threonine kinase 10 multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in increased expression of STK10 mRNA] CTD PMID:16140955 NCBI chr10:17,420,964...17,521,810
Ensembl chr10:17,421,075...17,519,706
JBrowse link
G Tgm2 transglutaminase 2 multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in increased expression of TGM2 mRNA] CTD PMID:16140955 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO Thiophenes analog promotes the reaction [Tretinoin results in increased expression of TNFSF10 mRNA] CTD PMID:16140955 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
(S)-duloxetine hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Duloxetine Hydrochloride binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity
multiple interactions
ISO Duloxetine Hydrochloride results in decreased activity of CYP17A1 protein
Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone]; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone]; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone]; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione]; Duloxetine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased hydroxylation of Pregnenolone]; Duloxetine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased hydroxylation of Progesterone]; Duloxetine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone]; Duloxetine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone]
CTD PMID:29100959 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP [furafylline results in decreased activity of CYP1A2 protein] which results in decreased glutathionylation of Duloxetine Hydrochloride; CYP1A2 protein results in increased activity of and results in increased glutathionylation of Duloxetine Hydrochloride CTD PMID:20669986 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions EXP [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased glutathionylation of Duloxetine Hydrochloride; CYP2D6 protein results in increased activity of and results in increased glutathionylation of Duloxetine Hydrochloride CTD PMID:20669986 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Duloxetine Hydrochloride results in increased expression of HMOX1 mRNA CTD PMID:29134401 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Duloxetine Hydrochloride results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO Duloxetine Hydrochloride results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA]; Duloxetine Hydrochloride results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr 3:41,019,898...41,181,070
Ensembl chr 3:41,019,898...41,181,070
JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 multiple interactions ISO Duloxetine Hydrochloride results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA] CTD PMID:22164246 NCBI chr 8:33,435,493...33,463,410
Ensembl chr 8:33,433,905...33,463,467
JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 multiple interactions ISO Duloxetine Hydrochloride results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr11:35,011,007...35,262,362
Ensembl chr11:35,024,196...35,099,383
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization ISO Duloxetine Hydrochloride affects the localization of NFE2L2 protein CTD PMID:29134401 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Prl prolactin increases expression ISO Duloxetine Hydrochloride results in increased expression of PRL protein CTD PMID:17606668 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Carticaine inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein] CTD PMID:32687258 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Carticaine inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein] CTD PMID:32687258 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Calca calcitonin-related polypeptide alpha increases secretion ISO Carticaine results in increased secretion of CALCA protein CTD PMID:18172555 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Casp1 caspase 1 multiple interactions ISO Carticaine inhibits the reaction [Lipopolysaccharides results in increased expression of CASP1 protein] CTD PMID:32687258 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Carticaine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:32687258 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Carticaine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:32687258 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Carticaine inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein] CTD PMID:32687258 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO Carticaine inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein] CTD PMID:32687258 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Carticaine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:32687258 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Carticaine inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein] CTD PMID:32687258 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Carticaine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:32687258 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Carticaine inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein] CTD PMID:32687258 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Carticaine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:32687258 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases activity EXP Carticaine results in increased activity of TRPV1 protein CTD PMID:18172555 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
arotinolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions EXP arotinolol promotes the reaction [Thyroxine results in decreased expression of CAT protein] CTD PMID:2575990 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
azosemide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc12a2 solute carrier family 12 member 2 decreases activity
multiple interactions
ISO azosemide results in decreased activity of SLC12A2 protein
azosemide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]
CTD PMID:15517342, PMID:29959396 NCBI chr18:52,917,124...52,985,281
Ensembl chr18:52,917,124...52,985,261
JBrowse link
canagliflozin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP Canagliflozin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased activity of ACHE protein]; Canagliflozin inhibits the reaction [Scopolamine results in increased activity of ACHE protein] CTD PMID:27566243, PMID:28837785 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 decreases expression
multiple interactions
EXP Canagliflozin results in decreased expression of CHRM1 protein
Canagliflozin affects the reaction [Scopolamine results in decreased expression of CHRM1 protein]
CTD PMID:28837785 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression EXP Canagliflozin results in increased expression of HAVCR1 CTD PMID:25130857 NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP Canagliflozin results in increased expression of LHB protein CTD PMID:25289773 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Pth parathyroid hormone decreases expression EXP Canagliflozin results in decreased expression of PTH protein CTD PMID:25289773 NCBI chr 1:178,215,829...178,218,761
Ensembl chr 1:178,215,829...178,218,761
JBrowse link
G Slc5a2 solute carrier family 5 member 2 decreases activity ISO Canagliflozin results in decreased activity of SLC5A2 protein CTD PMID:21128592 NCBI chr 1:199,682,688...199,688,809
Ensembl chr 1:199,682,688...199,688,809
JBrowse link
cefalotin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of ABCB11 mRNA CTD PMID:24657338 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of ABCC2 mRNA CTD PMID:24657338 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of ABCC3 mRNA CTD PMID:24657338 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Cephalothin results in increased expression of BAX protein CTD PMID:15012731 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Cephalothin results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:15012731 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in decreased expression of CYP8B1 mRNA CTD PMID:24657338 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388
JBrowse link
G Fgf19 fibroblast growth factor 19 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of FGF15 mRNA CTD PMID:24657338 NCBI chr 1:218,058,405...218,061,693
Ensembl chr 1:218,058,405...218,061,693
JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of NPC1L1 mRNA CTD PMID:24657338 NCBI chr14:86,345,946...86,560,694
Ensembl chr14:86,345,953...86,560,694
JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of NR5A2 mRNA CTD PMID:24657338 NCBI chr13:53,750,470...53,870,288
Ensembl chr13:53,750,473...53,870,428
JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of SLC10A1 mRNA CTD PMID:24657338 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link
G Slc25a20 solute carrier family 25 member 20 multiple interactions EXP Cephalothin binds to and results in decreased activity of SLC25A20 protein; Cephalothin inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine] CTD PMID:18452908 NCBI chr 8:117,455,308...117,476,762
Ensembl chr 8:117,455,262...117,476,734
JBrowse link
G Slc51b solute carrier family 51 subunit beta multiple interactions ISO [Cephalothin co-treated with Neomycin] results in decreased expression of SLC51B mRNA CTD PMID:24657338 NCBI chr 8:70,930,196...70,938,559
Ensembl chr 8:70,930,347...70,932,986
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of SLCO1B2 mRNA CTD PMID:24657338 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Cephalothin results in increased expression of TP53 protein CTD PMID:15012731 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vdr vitamin D receptor multiple interactions ISO [Cephalothin co-treated with Neomycin] results in increased expression of VDR mRNA CTD PMID:24657338 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
dorzolamide hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ca3 carbonic anhydrase 3 multiple interactions ISO dorzolamide binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO dorzolamide binds to and results in decreased activity of CA2 protein CTD PMID:17826101 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
DuP 697 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO DuP 697 inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein] CTD PMID:21163909 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases activity
EXP
ISO
[DuP 697 results in decreased expression of PTGS2] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased abundance of Dinoprostone]
DuP 697 results in decreased activity of PTGS2 protein
CTD PMID:19397918, PMID:25451575 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO DuP 697 results in increased expression of TNFRSF10A protein CTD PMID:15572759 NCBI chr15:51,433,853...51,464,215 JBrowse link
G Vegfa vascular endothelial growth factor A affects secretion ISO DuP 697 affects the secretion of VEGFA protein CTD PMID:15705899 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
eprosartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col1a1 collagen type I alpha 1 chain decreases expression EXP eprosartan decreases expression of collagen I-a1 mRNA in high fat high sodium fed SHRSP/A3N rat kidney RGD PMID:11907153 RGD:28912746 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression EXP eprosartan decreases expression of collagen III mRNA in high fat high sodium fed SHRSP/A3N rat kidney RGD PMID:11907153 RGD:28912746 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Fn1 fibronectin 1 decreases expression EXP eprosartan decreases expression of fibronectin mRNA in high fat high sodium fed SHRSP/A3N rat kidney RGD PMID:11907153 RGD:28912746 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Serpine1 serpin family E member 1 decreases expression EXP eprosartan decreases expression of plasminogen activator inhibitor -1 mRNA in high fat high sodium fed SHRSP/A3N rat kidney RGD PMID:11907153 RGD:28912746 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression EXP eprosartan decreases expression of TGFbeta mRNA in high fat high sodium fed SHRSP/A3N rat kidney RGD PMID:11907153 RGD:28912746 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
nocodazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression ISO Nocodazole results in decreased expression of ABCC2 mRNA; Nocodazole results in decreased expression of ABCC2 protein CTD PMID:10691972 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression ISO Nocodazole results in increased expression of ABCC3 mRNA CTD PMID:10691972 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression
multiple interactions
ISO Nocodazole results in increased expression of ACTA2 mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Nocodazole results in increased expression of ACTA2 mRNA]
CTD PMID:31170432 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Ahr aryl hydrocarbon receptor decreases activity ISO
EXP
Nocodazole results in decreased activity of AHR protein CTD PMID:16611024 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Anapc2 anaphase promoting complex subunit 2 multiple interactions ISO Nocodazole promotes the reaction [CCAR1 protein binds to ANAPC2 protein] CTD PMID:21903591 NCBI chr 3:2,490,496...2,502,247
Ensembl chr 3:2,490,518...2,502,248
JBrowse link
G Ar androgen receptor multiple interactions
decreases localization
ISO Nocodazole inhibits the reaction [Dihydrotestosterone results in increased localization of AR protein]
Nocodazole results in decreased localization of AR protein
CTD PMID:20807808 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Atp7b ATPase copper transporting beta multiple interactions ISO Nocodazole inhibits the reaction [Copper affects the localization of ATP7B protein] CTD PMID:10982773 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
JBrowse link
G Aurka aurora kinase A multiple interactions ISO [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Nocodazole] results in increased expression of and results in increased phosphorylation of AURKA protein; MLN8054 inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Nocodazole] results in increased phosphorylation of AURKA protein] CTD PMID:24976383 NCBI chr 3:170,364,177...170,380,278
Ensembl chr 3:170,364,181...170,378,210
JBrowse link
G Aurkb aurora kinase B multiple interactions ISO 4-(4-(N-benzoylamino)anilino)-6-methoxy-7-(3-(1-morpholino)propoxy)quinazoline inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Nocodazole] results in increased phosphorylation of AURKB protein]; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Nocodazole] results in increased phosphorylation of AURKB protein CTD PMID:24976383 NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Nocodazole analog results in increased expression of BAX protein CTD PMID:28412508 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases phosphorylation
decreases expression
multiple interactions
ISO Nocodazole results in increased phosphorylation of BCL2 protein
Nocodazole analog results in decreased expression of BCL2 protein
TYMP inhibits the reaction [Nocodazole results in increased phosphorylation of BCL2 protein]
CTD PMID:15907805, PMID:28412508 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO Nocodazole affects the reaction [BIRC5 protein affects the susceptibility to Melphalan] CTD PMID:16373717 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase multiple interactions
increases phosphorylation
ISO [Nocodazole co-treated with Caffeine] results in increased expression of BUB1 protein modified form; chromium hexavalent ion inhibits the reaction [Nocodazole results in increased phosphorylation of BUB1 protein] CTD PMID:21670593 NCBI chr 3:120,373,604...120,404,910
Ensembl chr 3:120,373,604...120,404,910
JBrowse link
G Capza1 capping actin protein of muscle Z-line subunit alpha 1 multiple interactions ISO [CAPZA1 protein co-treated with CAPZA2 protein] results in decreased susceptibility to Nocodazole CTD PMID:22918941 NCBI chr 2:207,305,748...207,350,812
Ensembl chr 2:207,305,752...207,350,812
JBrowse link
G Capza2 capping actin protein of muscle Z-line subunit alpha 2 multiple interactions ISO [CAPZA1 protein co-treated with CAPZA2 protein] results in decreased susceptibility to Nocodazole CTD PMID:22918941 NCBI chr 4:44,936,290...44,972,270
Ensembl chr 4:44,936,290...44,972,267
JBrowse link
G Casp3 caspase 3 increases cleavage
decreases expression
ISO Nocodazole results in increased cleavage of CASP3 protein
Nocodazole analog results in decreased expression of CASP3 protein
CTD PMID:21903591, PMID:28412508 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage
ISO Caspase Inhibitors inhibits the reaction [Nocodazole analog results in increased expression of CASP8 protein modified form]
Nocodazole analog results in increased cleavage of CASP8 protein
CTD PMID:28412508 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases cleavage ISO Nocodazole analog results in increased cleavage of CASP9 protein CTD PMID:28412508 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccar1 cell division cycle and apoptosis regulator 1 multiple interactions
increases expression
ISO Nocodazole inhibits the reaction [sodium arsenite affects the localization of CCAR1 protein]; Nocodazole promotes the reaction [CCAR1 protein binds to ANAPC2 protein]
Nocodazole results in increased expression of CCAR1 protein
CTD PMID:19073175, PMID:21903591 NCBI chr20:32,373,443...32,416,044
Ensembl chr20:32,373,443...32,416,044
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Nocodazole results in increased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO Nocodazole analog results in increased expression of CCNB1 protein; Nocodazole results in increased expression of CCNB1 protein CTD PMID:21670593, PMID:28412508 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression ISO Nocodazole analog results in increased expression of CDK1 protein CTD PMID:28412508 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdt1 chromatin licensing and DNA replication factor 1 multiple interactions ISO [Nocodazole co-treated with chromium hexavalent ion] results in decreased expression of and results in decreased phosphorylation of CDT1 protein CTD PMID:21670593 NCBI chr19:55,381,565...55,386,511
Ensembl chr19:55,381,565...55,386,511
JBrowse link
G Cftr CF transmembrane conductance regulator affects localization
multiple interactions
ISO
EXP
Nocodazole affects the localization of CFTR protein
Nocodazole inhibits the reaction [Cyclic AMP affects the localization of and results in increased activity of CFTR protein]
CTD PMID:12529251, PMID:15994425 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Chek1 checkpoint kinase 1 decreases expression ISO Nocodazole results in decreased expression of CHEK1 protein CTD PMID:26914363 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Nocodazole inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Nocodazole inhibits the reaction [Quercetin results in increased secretion of CSF2 protein] CTD PMID:18346843 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO
EXP
Nocodazole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Nocodazole inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Nocodazole inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
Nocodazole inhibits the reaction [benzotriphenylene results in increased expression of and results in increased activity of CYP1A1 protein]; Nocodazole inhibits the reaction [benzotriphenylene results in increased expression of CYP1A1 mRNA]
CTD PMID:8190110, PMID:16611024 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Egf epidermal growth factor multiple interactions ISO Nocodazole inhibits the reaction [EGF protein results in increased expression of PSA mRNA] CTD PMID:20807808 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Faslg Fas ligand multiple interactions ISO [TYMP co-treated with Nocodazole] results in decreased expression of FASLG mRNA; [TYMP co-treated with Nocodazole] results in decreased expression of FASLG protein CTD PMID:15907805 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fbxo5 F-box protein 5 multiple interactions ISO [Nocodazole co-treated with chromium hexavalent ion] results in decreased expression of FBXO5 protein CTD PMID:21670593 NCBI chr 1:42,461,277...42,467,646
Ensembl chr 1:42,461,291...42,467,586
JBrowse link
G Fis1 fission, mitochondrial 1 increases expression EXP Nocodazole results in increased expression of FIS1 protein CTD PMID:26732598 NCBI chr12:22,750,485...22,765,324
Ensembl chr12:22,750,485...22,765,308
JBrowse link
G Gmnn geminin, DNA replication inhibitor multiple interactions ISO [Nocodazole co-treated with chromium hexavalent ion] results in increased ubiquitination of GMNN protein CTD PMID:21670593 NCBI chr17:42,302,523...42,310,783
Ensembl chr17:42,302,540...42,310,783
JBrowse link
G H2ax H2A.X variant histone increases expression ISO Nocodazole results in increased expression of H2AX protein modified form CTD PMID:26914363 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression ISO Nocodazole results in decreased expression of HAMP mRNA CTD PMID:25633564 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression EXP Nocodazole results in increased expression of HSPA5 protein CTD PMID:26732598 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Il6r interleukin 6 receptor increases expression ISO Nocodazole results in increased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation
multiple interactions
ISO Nocodazole results in increased phosphorylation of JUN protein
TP53 protein affects the reaction [Nocodazole results in increased phosphorylation of JUN protein]
CTD PMID:12221076 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Lcmt1 leucine carboxyl methyltransferase 1 decreases response to substance ISO LCMT1 results in decreased susceptibility to Nocodazole CTD PMID:17724024 NCBI chr 1:193,335,629...193,391,620
Ensembl chr 1:193,335,645...193,391,638
JBrowse link
G Lzts1 leucine zipper tumor suppressor 1 affects response to substance ISO LZTS1 protein affects the susceptibility to Nocodazole CTD PMID:17349584 NCBI chr16:22,250,452...22,306,667
Ensembl chr16:22,250,470...22,306,662
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Nocodazole results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Nocodazole results in increased phosphorylation of and results in increased activity of MAPK1 protein; TYMP affects the reaction [Nocodazole results in increased phosphorylation of and results in increased activity of MAPK1 protein]; U 0126 inhibits the reaction [Nocodazole results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Nocodazole inhibits the reaction [NGF protein results in increased activity of MAPK1 protein]
CTD PMID:15907805, PMID:17822405 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Nocodazole results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Nocodazole results in increased phosphorylation of and results in increased activity of MAPK3 protein; TYMP affects the reaction [Nocodazole results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [Nocodazole results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Nocodazole inhibits the reaction [NGF protein results in increased activity of MAPK3 protein]
CTD PMID:15907805, PMID:17822405 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
ISO TP53 protein affects the reaction [Nocodazole results in increased phosphorylation of MAPK8 protein] CTD PMID:12221076 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions
ISO Nocodazole results in increased phosphorylation of MAPK9 protein
TP53 protein affects the reaction [Nocodazole results in increased phosphorylation of MAPK9 protein]
CTD PMID:12221076 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO Nocodazole results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Myt1 myelin transcription factor 1 increases phosphorylation ISO Nocodazole results in increased phosphorylation of MYT1 protein CTD PMID:16611024 NCBI chr 3:177,281,365...177,341,550
Ensembl chr 3:177,310,753...177,341,547
JBrowse link
G Nanog Nanog homeobox decreases expression ISO Nocodazole results in decreased expression of NANOG protein CTD PMID:21559451 NCBI chr 4:155,531,906...155,539,268
Ensembl chr 4:155,531,906...155,539,268
JBrowse link
G Ngf nerve growth factor multiple interactions EXP Nocodazole inhibits the reaction [NGF protein affects the localization of NTRK1 protein]; Nocodazole inhibits the reaction [NGF protein affects the localization of RAP1A protein]; Nocodazole inhibits the reaction [NGF protein results in increased activity of MAPK1 protein]; Nocodazole inhibits the reaction [NGF protein results in increased activity of MAPK3 protein]; Nocodazole inhibits the reaction [NGF protein results in increased activity of RAP1A protein] CTD PMID:17822405 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 multiple interactions ISO Nocodazole inhibits the reaction [NPC1 protein results in increased secretion of Daunorubicin] CTD PMID:16174794 NCBI chr18:3,616,878...3,662,656
Ensembl chr18:3,616,878...3,662,683
JBrowse link
G Npm1 nucleophosmin 1 affects phosphorylation ISO Nocodazole affects the phosphorylation of NPM1 protein CTD PMID:15190079 NCBI chr10:18,080,949...18,091,062
Ensembl chr10:18,080,950...18,090,950
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Nocodazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 multiple interactions EXP Nocodazole inhibits the reaction [NGF protein affects the localization of NTRK1 protein] CTD PMID:17822405 NCBI chr 2:187,143,568...187,160,373
Ensembl chr 2:187,143,568...187,160,373
JBrowse link
G Optn optineurin affects localization ISO Nocodazole affects the localization of OPTN protein CTD PMID:25096716 NCBI chr17:77,167,700...77,218,374
Ensembl chr17:77,167,740...77,218,389
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO TYMP inhibits the reaction [Nocodazole results in increased cleavage of PARP1 protein]
Nocodazole analog results in increased cleavage of PARP1 protein; Nocodazole results in increased cleavage of PARP1 protein
CTD PMID:15907805, PMID:21903591, PMID:28412508 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO Nocodazole results in decreased expression of POU5F1 protein CTD PMID:21559451 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha decreases response to substance ISO PPP2R2A results in decreased susceptibility to Nocodazole CTD PMID:17724024 NCBI chr15:43,673,958...43,733,182
Ensembl chr15:43,673,960...43,733,182
JBrowse link
G Qrich1 glutamine-rich 1 multiple interactions
increases phosphorylation
ISO Genistein inhibits the reaction [Nocodazole results in increased phosphorylation of QRICH1 protein] CTD PMID:17510977 NCBI chr 8:117,305,803...117,346,738
Ensembl chr 8:117,307,339...117,346,736
JBrowse link
G Rangap1 RAN GTPase activating protein 1 multiple interactions ISO Nocodazole results in increased phosphorylation of [SUMO1 protein binds to RANGAP1 protein] CTD PMID:21646468 NCBI chr 7:122,939,266...122,967,178
Ensembl chr 7:122,940,376...122,967,178
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family multiple interactions EXP Nocodazole inhibits the reaction [NGF protein affects the localization of RAP1A protein]; Nocodazole inhibits the reaction [NGF protein results in increased activity of RAP1A protein] CTD PMID:17822405 NCBI chr 2:208,193,950...208,215,186
Ensembl chr 2:208,193,954...208,215,187
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Nocodazole inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein] CTD PMID:29247640 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Nocodazole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Sumo1 small ubiquitin-like modifier 1 multiple interactions ISO Nocodazole results in increased phosphorylation of [SUMO1 protein binds to RANGAP1 protein] CTD PMID:21646468 NCBI chr 9:66,453,428...66,483,614
Ensembl chr 9:66,453,438...66,483,614
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO TP53 protein affects the reaction [Nocodazole results in increased phosphorylation of JUN protein]; TP53 protein affects the reaction [Nocodazole results in increased phosphorylation of MAPK8 protein]; TP53 protein affects the reaction [Nocodazole results in increased phosphorylation of MAPK9 protein]
Nocodazole analog results in increased expression of TP53 protein; Nocodazole results in increased expression of TP53 protein
CTD PMID:12221076, PMID:21559451, PMID:28412508 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tuba1a tubulin, alpha 1A multiple interactions ISO Nocodazole inhibits the reaction [TUBA1A protein binds to TUBA1A protein] CTD PMID:19222062 NCBI chr 7:140,637,287...140,640,953
Ensembl chr 7:140,637,287...140,640,953
JBrowse link
G Tymp thymidine phosphorylase multiple interactions ISO [TYMP co-treated with Nocodazole] results in decreased expression of FASLG mRNA; [TYMP co-treated with Nocodazole] results in decreased expression of FASLG protein; TYMP affects the reaction [Nocodazole results in increased phosphorylation of and results in increased activity of MAPK1 protein]; TYMP affects the reaction [Nocodazole results in increased phosphorylation of and results in increased activity of MAPK3 protein]; TYMP inhibits the reaction [Nocodazole results in increased cleavage of PARP1 protein]; TYMP inhibits the reaction [Nocodazole results in increased phosphorylation of BCL2 protein] CTD PMID:15907805 NCBI chr 7:130,342,481...130,347,845
Ensembl chr 7:130,342,483...130,347,587
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Nocodazole results in increased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
pyrantel term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing ISO CYP2D6 protein affects the metabolism of Pyrantel CTD PMID:12920490 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
rivaroxaban term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Rivaroxaban inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:30719803 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Alb albumin multiple interactions EXP Rivaroxaban inhibits the reaction [Carbon Tetrachloride results in decreased expression of ALB protein] CTD PMID:30719803 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G F10 coagulation factor X decreases activity ISO Rivaroxaban results in decreased activity of F10 protein CTD PMID:16084352 NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions EXP Rivaroxaban inhibits the reaction [Carbon Tetrachloride results in increased expression of F3 protein] CTD PMID:30719803 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Rivaroxaban inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein] CTD PMID:30719803 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Rivaroxaban inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein] CTD PMID:30719803 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Rivaroxaban inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein] CTD PMID:30719803 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Rivaroxaban inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein] CTD PMID:30719803 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
sufentanil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr3a 5-hydroxytryptamine receptor 3A affects activity ISO Sufentanil affects the activity of HTR3A protein CTD PMID:18635474 NCBI chr 8:53,211,436...53,223,878
Ensembl chr 8:53,211,438...53,223,804
JBrowse link
G Pomc proopiomelanocortin decreases expression ISO Sufentanil results in decreased expression of POMC protein modified form CTD PMID:15714323 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
suprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhrs11 dehydrogenase/reductase 11 decreases activity ISO Suprofen results in decreased activity of DHRS11 protein CTD PMID:30926317 NCBI chr10:72,144,042...72,153,496
Ensembl chr10:72,144,042...72,153,375
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Suprofen results in increased expression of GCLC mRNA CTD PMID:11909699 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Suprofen results in increased expression of GCLM mRNA CTD PMID:11909699 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
tenidap term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase decreases activity
multiple interactions
ISO tenidap results in decreased activity of ALOX5 protein
[tenidap results in decreased activity of ALOX5 protein] which results in decreased chemical synthesis of Leukotriene B4; [tenidap results in decreased activity of ALOX5 protein] which results in increased abundance of 15-hydroxy-5,8,11,13-eicosatetraenoic acid
CTD PMID:2849922 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Slc26a3 solute carrier family 26 member 3 decreases activity ISO tenidap results in decreased activity of SLC26A3 protein CTD PMID:12651923 NCBI chr 6:50,725,085...50,766,306
Ensembl chr 6:50,725,085...50,766,300
JBrowse link
teniposide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases response to substance ISO ABCC1 results in decreased susceptibility to Teniposide CTD PMID:8968083 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Ar androgen receptor multiple interactions ISO Teniposide binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Teniposide results in increased expression of CDKN1A mRNA; Teniposide results in increased expression of CDKN1A protein CTD PMID:25914138 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases methylation ISO CYP3A5 protein results in decreased methylation of Teniposide CTD PMID:8114683 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Teniposide binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Teniposide binds to and results in decreased activity of ESR2 protein CTD PMID:25752796 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases response to substance ISO FGF2 protein results in decreased susceptibility to Teniposide CTD PMID:20221717 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Teniposide inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Mir135b microRNA 135b decreases response to substance ISO MIR135B mRNA results in decreased susceptibility to Teniposide CTD PMID:27570640 NCBI chr13:48,976,986...48,977,082
Ensembl chr13:48,976,986...48,977,082
JBrowse link
G Mir196b microRNA 196b decreases response to substance ISO MIR196B mRNA results in decreased susceptibility to Teniposide CTD PMID:27570640 NCBI chr 4:82,199,056...82,199,140
Ensembl chr 4:82,199,056...82,199,140
JBrowse link
G Mttp microsomal triglyceride transfer protein decreases expression
multiple interactions
ISO Teniposide results in decreased expression of MTTP mRNA
Teniposide promotes the reaction [CETP protein results in decreased expression of MTTP mRNA]
CTD PMID:25914138 NCBI chr 2:243,366,181...243,407,608
Ensembl chr 2:243,366,181...243,407,608
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO Teniposide results in decreased expression of MYC mRNA; Teniposide results in decreased expression of MYC protein CTD PMID:11585056 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 multiple interactions
affects localization
affects response to substance
ISO NR1H2 mutant form inhibits the reaction [Teniposide results in increased expression of CETP mRNA]; Teniposide promotes the reaction [NR1H2 protein results in increased expression of CETP mRNA]
Teniposide affects the localization of NR1H2 protein
NR1H2 protein affects the susceptibility to Teniposide
CTD PMID:25914138 NCBI chr 1:100,554,577...100,559,896
Ensembl chr 1:100,554,544...100,559,942
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions
increases expression
affects response to substance
ISO NR1H3 mutant form inhibits the reaction [Teniposide results in increased expression of CETP mRNA]; Teniposide promotes the reaction [NR1H3 protein results in increased expression of CETP mRNA]; Teniposide results in increased expression of and affects the localization of NR1H3 protein
Teniposide results in increased expression of NR1H3 mRNA
NR1H3 protein affects the susceptibility to Teniposide
CTD PMID:25914138 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
JBrowse link
G Nrip1 nuclear receptor interacting protein 1 decreases expression ISO Teniposide results in decreased expression of NRIP1 mRNA; Teniposide results in decreased expression of NRIP1 protein CTD PMID:25914138 NCBI chr11:14,658,225...14,742,478
Ensembl chr11:14,658,225...14,741,563
JBrowse link
G Odc1 ornithine decarboxylase 1 decreases expression ISO Teniposide results in decreased expression of ODC1 protein CTD PMID:11585056 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Teniposide binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO Teniposide promotes the reaction [RXRA protein results in increased expression of CETP mRNA]; Tretinoin promotes the reaction [Teniposide promotes the reaction [RXRA protein results in increased expression of CETP mRNA]] CTD PMID:25914138 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions ISO Teniposide inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue] CTD PMID:30863990 NCBI chr 1:164,623,313...164,671,612
Ensembl chr 1:164,623,599...164,671,577
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Teniposide binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Teniposide binds to and results in decreased activity of THRB protein CTD PMID:25752796 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions ISO TOP2A results in decreased susceptibility to [Cisplatin co-treated with Teniposide] CTD PMID:11325482 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
tiagabine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase decreases activity EXP tiagabine results in decreased activity of AADAT protein CTD PMID:16765940 NCBI chr16:32,832,001...32,868,680
Ensembl chr16:32,832,061...32,868,702
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
EXP Amino Acids, Peptides, and Proteins inhibits the reaction [tiagabine results in increased expression of ABCB1 protein] CTD PMID:18473823 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression EXP tiagabine results in increased expression of ABCC1 protein CTD PMID:18473823 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP tiagabine results in increased expression of ABCC2 protein CTD PMID:18473823 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO tiagabine results in decreased activity of CYP19A1 protein CTD PMID:17959350 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Kyat1 kynurenine aminotransferase 1 decreases activity EXP tiagabine results in decreased activity of KYAT1 protein CTD PMID:16765940 NCBI chr 3:8,752,289...8,785,617
Ensembl chr 3:8,752,625...8,766,433
JBrowse link
G Slc6a1 solute carrier family 6 member 1 decreases activity ISO tiagabine results in decreased activity of SLC6A1 protein CTD PMID:15788781 NCBI chr 4:146,258,842...146,292,176
Ensembl chr 4:146,276,862...146,292,213
JBrowse link
tiaprofenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbr1 carbonyl reductase 1 increases reduction ISO CBR1 protein results in increased reduction of tiaprofenic acid CTD PMID:28322780 NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO tiaprofenic acid results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions
increases glucuronidation
ISO tiaprofenic acid inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; tiaprofenic acid inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]
UGT2B7 protein alternative form results in increased glucuronidation of tiaprofenic acid; UGT2B7 protein results in increased glucuronidation of tiaprofenic acid
CTD PMID:8423545, PMID:8517101, PMID:19740398 NCBI chr14:22,597,103...22,619,968 JBrowse link
tienilic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity
multiple interactions
ISO Ticrynafen results in decreased activity of CYP2B6 protein
Ticrynafen inhibits the reaction [CYP2B6 protein results in increased chemical synthesis of hydroxybupropion]; Ticrynafen inhibits the reaction [CYP2B6 protein results in increased metabolism of Bupropion]
CTD PMID:21915887 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Ticrynafen results in increased expression of HMOX1 mRNA CTD PMID:18227147 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ren renin increases activity ISO Ticrynafen results in increased activity of REN protein CTD PMID:6756707 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Slc12a2 solute carrier family 12 member 2 decreases activity
multiple interactions
ISO Ticrynafen results in decreased activity of SLC12A2 protein
Ticrynafen inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]
CTD PMID:29959396 NCBI chr18:52,917,124...52,985,281
Ensembl chr18:52,917,124...52,985,261
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO Ticrynafen results in increased expression of UGT1A1 mRNA CTD PMID:18227147 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
tiquizium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO thiaton results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP thiaton inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:11855677 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP thiaton inhibits the reaction [Indomethacin results in increased activity of NOS2 protein] CTD PMID:11855677 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      atom 19782
        nonmetal atom 19657
          sulfur atom 16255
            sulfur molecular entity 16255
              organosulfur compound 15188
                organosulfur heterocyclic compound 5834
                  thiophenes 194
                    (1E)-2-(5-chlorothiophen-2-yl)-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}prop-1-ene-1-sulfonamide 0
                    (2,5-Dichlorothiophen-3-yl)methyl N-(pyridin-3-ylmethyl)carbamodithioate 0
                    (2-amino-5-methyl-3-thiophenyl)-thiophen-2-ylmethanone 0
                    (2R)-5-methyl-2-\{(1R)-2-oxo-1-[(2-thienylacetyl)amino]ethyl\}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid 0
                    (2R)-5-methylene-2-\{(1R)-2-oxo-1-[(2-thienylacetyl)amino]ethyl\}-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid 0
                    (2S)-2-\{(R)-carboxy[(2-thienylacetyl)amino]methyl\}-5-methyl-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid 0
                    (2S,4S,5R)-2-isobutyl-5-(2-thienyl)-1-[4-(trifluoromethyl)benzoyl]pyrrolidine-2,4-dicarboxylic acid 0
                    (4R)-4-hydroxy-2-(thien-2-ylmethyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide 0
                    (4S)-2-\{(R)-carboxy-[(2-thien-2-ylacetyl)amino]methyl\}-5-methylene-5,6-dihydro-4H-1,3-thiazine-4-carboxylic acid 0
                    (4S)-4-\{[(5-amino-6-oxo-2-thiophen-2-ylpyrimidin-1(6H)-yl)acetyl]amino\}-2,2-difluoro-5-methyl-N-(2-morpholin-4-ylethyl)-3-oxohexanamide 0
                    (5-bromo-2-thiophenyl)-[4-(3-phenylprop-2-enyl)-1-piperazinyl]methanone 0
                    (E)-2-(5-chlorothiophen-2-yl)-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}ethenesulfonamide 0
                    1,3-dimethyl-6-[2-(thiophen-2-ylmethylidene)hydrazinyl]pyrimidine-2,4-dione 0
                    1,4-bis(thiophen-2-ylsulfonyl)piperazine 0
                    1-(2-methylphenyl)-3-[[(5-methyl-3-thiophenyl)-oxomethyl]amino]thiourea 0
                    1-(3-methylphenyl)-3-[[(5-methyl-3-thiophenyl)-oxomethyl]amino]thiourea 0
                    1-(3-methylphenyl)-3-[[oxo-(5-propyl-3-thiophenyl)methyl]amino]thiourea 0
                    1-(4-chlorophenyl)-3-[4-methyl-2-(thiophen-2-yl)-1,3-thiazol-5-yl]urea 0
                    1-(5-nitro-2-thiophenyl)piperidine 0
                    1-[(2-chlorophenyl)methyl]-3-methyl-N-(4-methyl-2-thiazolyl)-5-thieno[2,3-c]pyrazolecarboxamide 0
                    1-[(5-bromo-2-thiophenyl)sulfonyl]-3-methylpiperidine 0
                    1-[[(4-ethyl-5-methyl-3-thiophenyl)-oxomethyl]amino]-3-(2-phenylethyl)thiourea 0
                    1-\{2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl\}imidazole + 0
                    1-\{[5-(5-chloro-2-thienyl)isoxazol-3-yl]methyl\}-3-cyano-N-(1-isopropylpiperidin-4-yl)-7-methyl-1H-indole-2-carboxamide 0
                    1-\{[5-(5-chloro-2-thienyl)isoxazol-3-yl]methyl\}-N-(1-isopropylpiperidin-4-yl)-1H-indole-2-carboxamide 0
                    1-butyl-3-[[(4,5-dimethyl-3-thiophenyl)-oxomethyl]amino]thiourea 0
                    1-butyl-3-[[oxo-(5-propan-2-yl-3-thiophenyl)methyl]amino]thiourea 0
                    1-cyclohexyl-3-[[oxo(thiophen-2-yl)methyl]amino]thiourea 0
                    1-methyl-N-[2-(4-methylpentan-2-yl)-3-thienyl]-3-(trifluoromethyl)pyrazole-4-carboxamide + 0
                    2,2'-bithiophenes + 0
                    2,5-dichloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-3-thiophenecarboxamide 0
                    2-(2-chlorophenyl)-5-(5-methyl-2-thienyl)-1,3,4-oxadiazole 0
                    2-(4-\{5-[(1H-benzimidazol-2-ylamino)methyl]thiophen-2-yl\}-1,3-thiazol-2-yl)guanidine 0
                    2-(5-butylthiophen-2-yl)-2,5-dihydropyrazolo[4,3-c]quinolin-3-one 0
                    2-(5-chlorothiophen-2-yl)-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}ethanesulfonamide 0
                    2-(carbamoylamino)-5-(4-fluorophenyl)-3-thiophenecarboxamide 0
                    2-Pentylthiophene 0
                    2-Thiophenesulfonamide 0
                    2-[2-[[2-[(3-carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)amino]-2-oxoethyl]thio]-4-thiazolyl]acetic acid ethyl ester 0
                    2-[[1-oxo-2-(1H-1,2,4-triazol-5-ylthio)ethyl]amino]-4-thiophen-2-yl-3-thiophenecarboxylic acid ethyl ester 0
                    2-[[2-[5-(4-morpholinylsulfonyl)-2-thiophenyl]-1-oxoethyl]amino]-5-phenyl-3-thiophenecarboxamide 0
                    2-[[2-[[4-(2-furanylmethyl)-5-(phenylmethyl)-1,2,4-triazol-3-yl]thio]-1-oxoethyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide 0
                    2-[[2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]thio]-1-oxoethyl]amino]-3-thiophenecarboxamide 0
                    2-[[cyclohexyl(oxo)methyl]amino]-3-thiophenecarboxamide 0
                    2-[[oxo(thiophen-2-yl)methyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid propan-2-yl ester 0
                    2-[[oxo(thiophen-2-yl)methyl]amino]-6-propyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide 0
                    2-\{4-[(4-amino-2-methylpyrimidin-5-yl)methyl]-3-methylthiophen-2-yl\}ethyl trihydrogen diphosphate 0
                    2-amino-5-[diethylamino(oxo)methyl]-4-methyl-3-thiophenecarboxylic acid propan-2-yl ester 0
                    2-chloro-N-(2,4-dimethylthiophen-3-yl)-N-(1-methoxypropan-2-yl)acetamide + 0
                    2-chloro-N-[(5-chloro-2-thiophenyl)methyl]-N-methylacetamide 0
                    2-methylthiophene 0
                    2-thienylacetic acid + 0
                    2-thienylacetonitrile 0
                    3,4-Dimethylthiophene 0
                    3-(5-butyl-2-thiophenyl)-2-cyano-2-propenethioamide 0
                    3-(5-ethyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-4-prop-2-enyl-1H-1,2,4-triazole-5-thione 0
                    3-(5-nitro-2-thiophenyl)-1-(1-pyrrolidinyl)-2-propen-1-one 0
                    3-(carbamoylamino)-5-(3-fluorophenyl)-N-[(3R)-3-piperidinyl]-2-thiophenecarboxamide 0
                    3-(carbamoylamino)-5-(3-fluorophenyl)-N-[(3S)-3-piperidinyl]-2-thiophenecarboxamide 0
                    3-Methylthiophene 0
                    3-[isopropyl(4-methylbenzoyl)amino]-5-phenylthiophene-2-carboxylic acid 0
                    3-amino-5-(3-thiophenyl)-2-thiophenecarboxamide 0
                    3-amino-5-methyl-4-[[3-(4-morpholinyl)propylamino]-oxomethyl]-2-thiophenecarboxylic acid ethyl ester 0
                    3-chloro-4-propan-2-ylsulfonyl-2-thiophenecarbohydrazide 0
                    3-ethyl-2-sulfanylidene-5-thiophen-2-yl-1H-thieno[2,3-d]pyrimidin-4-one 0
                    3-formylthiophene 0
                    3-methylthiofentanyl + 0
                    4,5-dimethyl-2-[[oxo(thiophen-2-yl)methyl]amino]-3-thiophenecarboxylic acid ethyl ester 0
                    4,5-dimethyl-N-(3-thiophenylmethylideneamino)-3-thiophenecarboxamide 0
                    4,5-dimethyl-N-[[4-(2-methylpropoxy)phenyl]methylideneamino]-3-thiophenecarboxamide 0
                    4-(2,5-dichlorothiophen-3-yl)pyrimidin-2-amine 0
                    4-(2-thienyl)butyric acid 0
                    4-(4-methylpiperazin-1-yl)-N-[5-(2-thienylacetyl)-1,5-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide 0
                    4-(5-bromo-2-thiophenyl)-6-methyl-2-(1-pyrrolyl)pyrimidine 0
                    4-(5-ethyl-2-thienyl)-4-oxobutyric acid 0
                    4-[(5-bromo-2-thiophenyl)methylideneamino]-3-cyclohexyl-1H-1,2,4-triazole-5-thione 0
                    4-[5-(4-morpholinylsulfonyl)-2-thiophenyl]-3-phenyl-2H-furan-5-one 0
                    4-[5-amino-3-methyl-4-[oxo-[3-(trifluoromethyl)phenyl]methyl]-2-thiophenyl]butanoic acid 0
                    4-cyano-3-methyl-5-(4-methylphenyl)-2-thiophenecarbohydrazide 0
                    4-ethyl-5-methyl-N-[1-[(3-methylphenyl)methyl]-1,2,4-triazol-3-yl]-3-thiophenecarboxamide 0
                    4-hydroxy-3-(methylthio)-4,5,6,7-tetrahydro-2-benzothiophene-1-carbohydrazide 0
                    4-oxo-4-(2-thienyl)butyric acid 0
                    5-(4-chloro-5-phenylthiophen-3-yl)-1,2,5-thiadiazolidin-3-one 1,1-dioxide 0
                    5-(5-chlorothiophen-2-yl)-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}-1H-1,2,4-triazole-3-sulfonamide 0
                    5-(methylsulfanyl)-2-(thiophen-2-yl)-3-(trifluoromethyl)pyridine-4-carbonitrile 0
                    5-[(3-ethoxycarbonyl-4-thiophen-2-yl-2-thiophenyl)amino]-5-oxopentanoic acid 0
                    5-[(cyclohexylamino)-oxomethyl]-4-methyl-2-[(1-oxo-2-thiophen-2-ylethyl)amino]-3-thiophenecarboxylic acid ethyl ester 0
                    5-[[3-(1,5-dimethyl-4-pyrazolyl)-1-oxoprop-2-enyl]amino]-3-methylthiophene-2,4-dicarboxylic acid O2-ethyl ester O4-propan-2-yl ester 0
                    5-[diethylamino(oxo)methyl]-4-methyl-2-(1-oxopentylamino)-3-thiophenecarboxylic acid methyl ester 0
                    5-amino-3-(4-methoxyphenyl)-7-methyl-4-oxo-1-thieno[3,4-d]pyridazinecarboxylic acid methyl ester 0
                    5-amino-3-[[[1-(2-furanylmethyl)-5-oxo-3-pyrrolidinyl]-oxomethoxy]methyl]thiophene-2,4-dicarboxylic acid dimethyl ester 0
                    5-amino-N'-[(3-bromo-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]-4-cyano-3-methyl-2-thiophenecarbohydrazide 0
                    5-bromo-N-(2-oxolanylmethyl)-2-thiophenesulfonamide 0
                    5-bromo-N-(2-pyridinylmethyl)-2-thiophenesulfonamide 0
                    5-bromo-N-(5-cyclohexyl-1,3,4-thiadiazol-2-yl)-2-thiophenecarboxamide 0
                    5-bromo-N-(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)-2-thiophenecarboxamide 0
                    5-bromo-N-(pyridin-4-ylmethyl)-2-thiophenesulfonamide 0
                    5-bromo-N-[2-(4-chlorophenyl)ethyl]-2-thiophenecarboxamide 0
                    5-bromo-N-[[[oxo(thiophen-2-yl)methyl]hydrazo]-sulfanylidenemethyl]-2-furancarboxamide 0
                    5-methyl-N-(1-pyridin-4-ylethylideneamino)-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide 0
                    5-nitro-2-thiophenecarboxylic acid [1-[(3,5-dichloro-2-pyridinyl)amino]-1-oxopropan-2-yl] ester 0
                    5-nitro-2-thiophenecarboxylic acid [2-oxo-2-(1-phenylethylamino)ethyl] ester 0
                    5-nitro-2-thiophenecarboxylic acid [2-oxo-2-[(phenylmethyl)amino]ethyl] ester 0
                    5-nitro-2-thiophenecarboxylic acid [2-oxo-2-[[oxo-[(phenylmethyl)amino]methyl]amino]ethyl] ester 0
                    6-amino-4-(5-bromo-2-thiophenyl)-3-ethyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile 0
                    6-methyl-2-[2-[(3-methyl-2-thiophenyl)methylidene]hydrazinyl]-1H-pyrimidin-4-one 0
                    6-methyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide 0
                    Arotinolol hydrochloride 0
                    DuP 697 4
                    N'-[(3-phenyl-4-pyrazolylidene)methyl]-2-thiophenecarbohydrazide 0
                    N'-[4-(3-methoxyphenyl)-2-thiazolyl]-2-thiophenecarbohydrazide 0
                    N,4-dimethyl-5-phenyl-2-thiophenecarboxamide 0
                    N,N-diethyl-5-thiophen-2-yl-2-thiophenecarboxamide 0
                    N-(1,3-benzodioxol-5-ylmethyl)-2-[(3-methyl-4-oxo-5-thiophen-2-yl-2-thieno[2,3-d]pyrimidinyl)thio]acetamide 0
                    N-(1-thiophen-2-ylethylideneamino)-2-thiophenecarboxamide 0
                    N-(2-furanylmethyl)-5-(4-morpholinyl)-4-phenyl-2-thiophenecarboxamide 0
                    N-(2-furanylmethyl)-5-methyl-4-phenyl-3-thiophenecarboxamide 0
                    N-(2-furanylmethylideneamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide 0
                    N-(2-pyridinyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide 0
                    N-(2-tert-butyl-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-thiophenecarboxamide 0
                    N-(3-Methyl-4-nitro-1,2-oxazol-5-yl)-5-[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]thiophene-2-carboxamide 0
                    N-(3-carbamoyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-methyl-3-pyrazolecarboxamide 0
                    N-(3-carbamoyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-5-methyl-4-nitro-3-isoxazolecarboxamide 0
                    N-(3-carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-4-chloro-2-methyl-3-pyrazolecarboxamide 0
                    N-(3-carbamoyl-5-propyl-2-thiophenyl)-2-methyl-3-furancarboxamide 0
                    N-(3-carbamoyl-5-propyl-2-thiophenyl)-2-oxolanecarboxamide 0
                    N-(3-carbamoyl-6-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-3-(2-chlorophenyl)-5-methyl-4-isoxazolecarboxamide 0
                    N-(3-pyridinyl)-2,3-dihydrothieno[3,4-b][1,4]dioxin-5-carboxamide 0
                    N-(4-\{[(1H-benzotriazol-1-yl)acetyl][(thiophen-3-yl)methyl]amino\}phenyl)propanamide 0
                    N-(4-tert-butyl-2-thiazolyl)-5-methyl-2-thiophenecarboxamide 0
                    N-(6-methoxy-3-pyridinyl)-2-thiophenecarboxamide 0
                    N-(6-methoxy-3-pyridinyl)-3-methyl-2-thiophenecarboxamide 0
                    N-[(1S)-2-amino-1-(2,4-dichlorobenzyl)ethyl]-5-[2-(methylamino)pyrimidin-4-yl]thiophene-2-carboxamide 0
                    N-[(2-bromophenyl)methyl]-2-thiophenecarboxamide 0
                    N-[(2-ethyl-1-piperidinyl)-sulfanylidenemethyl]-2-thiophenecarboxamide 0
                    N-[(2-fluorophenyl)methyl]-2-thiophenecarboxamide 0
                    N-[(2-fluorophenyl)methylideneamino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide 0
                    N-[(2R,4aR,12aR)-2-[2-[(3-methoxyphenyl)methylamino]-2-oxoethyl]-5-methyl-6-oxo-2,3,4,4a,12,12a-hexahydropyrano[2,3-c][1,5]benzoxazocin-8-yl]-2-thiophenecarboxamide 0
                    N-[(2R,4aR,12aS)-2-[2-[(3-methoxyphenyl)methylamino]-2-oxoethyl]-5-methyl-6-oxo-2,3,4,4a,12,12a-hexahydropyrano[2,3-c][1,5]benzoxazocin-8-yl]-2-thiophenecarboxamide 0
                    N-[(2R,4aS,12aR)-2-[2-[(3-methoxyphenyl)methylamino]-2-oxoethyl]-5-methyl-6-oxo-2,3,4,4a,12,12a-hexahydropyrano[2,3-c][1,5]benzoxazocin-8-yl]-2-thiophenecarboxamide 0
                    N-[(2R,4aS,12aS)-2-[2-[(3-methoxyphenyl)methylamino]-2-oxoethyl]-5-methyl-6-oxo-2,3,4,4a,12,12a-hexahydropyrano[2,3-c][1,5]benzoxazocin-8-yl]-2-thiophenecarboxamide 0
                    N-[(2S,4aR,12aR)-2-[2-[(3-methoxyphenyl)methylamino]-2-oxoethyl]-5-methyl-6-oxo-2,3,4,4a,12,12a-hexahydropyrano[2,3-c][1,5]benzoxazocin-8-yl]-2-thiophenecarboxamide 0
                    N-[(2S,4aR,12aS)-2-[2-[(3-methoxyphenyl)methylamino]-2-oxoethyl]-5-methyl-6-oxo-2,3,4,4a,12,12a-hexahydropyrano[2,3-c][1,5]benzoxazocin-8-yl]-2-thiophenecarboxamide 0
                    N-[(2S,4aS,12aR)-2-[2-[(3-methoxyphenyl)methylamino]-2-oxoethyl]-5-methyl-6-oxo-2,3,4,4a,12,12a-hexahydropyrano[2,3-c][1,5]benzoxazocin-8-yl]-2-thiophenecarboxamide 0
                    N-[(2S,4aS,12aS)-2-[2-[(3-methoxyphenyl)methylamino]-2-oxoethyl]-5-methyl-6-oxo-2,3,4,4a,12,12a-hexahydropyrano[2,3-c][1,5]benzoxazocin-8-yl]thiophene-2-carboxamide 0
                    N-[(3,5,5-trimethyl-1-cyclohex-2-enylidene)amino]-2-thiophenecarboxamide 0
                    N-[(3-fluorophenyl)methylideneamino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide 0
                    N-[(3-methyl-2-thiophenyl)methylideneamino]-2-thiophenecarboxamide 0
                    N-[(5-\{2-[(6R)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl]ethyl\}thiophen-2-yl)carbonyl]-L-glutamic acid 0
                    N-[(5-acetyl-3-thienyl)methyl]-2-chloroacetamide semicarbazone 0
                    N-[(5R)-5-(3,4-dichlorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]thiophene-2-sulfonamide 0
                    N-[(R)-[(1R,2R)-2-butylcyclopropyl]-(4-chlorophenyl)methyl]-2-thiophenecarboxamide 0
                    N-[1-methyl-3-(trifluoromethyl)-5-thieno[2,3-c]pyrazolyl]carbamic acid 2,2-dimethylpropyl ester 0
                    N-[2,2-dimethyl-3-[[oxo(thiophen-2-yl)methyl]amino]propyl]-2-thiophenecarboxamide 0
                    N-[2-(4-fluorophenyl)ethyl]-5-methyl-2-thiophenecarboxamide 0
                    N-[2-(cyclohexylamino)-2-oxo-1-thiophen-2-ylethyl]-2,2,2-trifluoro-N-(4-methylphenyl)acetamide 0
                    N-[3-(3,5-dimethyl-1-piperidinyl)propyl]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide 0
                    N-[3-[(cyclopropylamino)-oxomethyl]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophen-2-yl]-2-furancarboxamide 0
                    N-[3-[oxo-(3-pyridinylmethylamino)methyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-2-furancarboxamide 0
                    N-[3-carbamoyl-5-[diethylamino(oxo)methyl]-4-methyl-2-thiophenyl]carbamic acid methyl ester 0
                    N-[5-(2,3-dihydro-1,4-dioxin-5-yl)-1,3,4-oxadiazol-2-yl]-5-nitro-2-thiophenecarboxamide 0
                    N-[5-(2-oxolanyl)-1,3,4-thiadiazol-2-yl]-2-thiophenecarboxamide 0
                    N-[5-(3-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-thiophenecarboxamide 0
                    N-[5-[(4-chlorophenoxy)methyl]-1,3,4-thiadiazol-2-yl]-2-thiophenecarboxamide 0
                    N-[[(5-chloro-2-pyridinyl)amino]-sulfanylidenemethyl]-2-thiophenecarboxamide 0
                    N-[cyano(2-thienyl)methyl]-4-ethyl-2-(ethylamino)-1,3-thiazole-5-carboxamide + 0
                    N-\{3-[4-(3-aminopropyl)piperazin-1-yl]propyl\}-3-(2-thiophen-2-ylacetylamino)-5-(3,4,5-trihydroxy-6-hydroxymethyltetrahydropyran-2-yloxy)benzamide 0
                    N-\{4-[(1H-benzotriazol-1-ylacetyl)(thiophen-3-ylmethyl)amino]phenyl\}-2-methylpropanamide 0
                    N-\{[5-(1-benzofuran-2-yl)thiophen-2-yl]methyl\}-N-[(2,4-dichlorophenyl)carbonyl]-L-phenylalanine 0
                    N-butyl-N(2)-(2-thienylacetyl)-L-alaninamide 0
                    N-butyl-N(2)-(2-thienylacetyl)-L-cysteinamide 0
                    N-butyl-N(2)-(2-thienylacetyl)-L-serinamide 0
                    N-ethyl-3-(1-pyrrolyl)-2-thiophenecarboxamide 0
                    N-methyl-5-phenyl-2-thiophenecarboxamide 0
                    N-propyl-N-(5-pyridin-4-yl-1,3,4-thiadiazol-2-yl)-2-thiophenecarboxamide 0
                    OSMI-1 0
                    [1-(4,5-diphenyl-2-thiophenyl)ethylideneamino]thiourea 0
                    [3,5-bis[(phenylmethyl)amino]-1,2,4-triazol-1-yl]-thiophen-2-ylmethanone 0
                    [3-(2-furanyl)-5-(phenylmethylthio)-1,2,4-triazol-1-yl]-thiophen-2-ylmethanone 0
                    [3-(2-hydroxyphenyl)-5-(4-methoxyphenyl)-3,4-dihydropyrazol-2-yl]-thiophen-2-ylmethanone 0
                    [3-methyl-4-[oxo(thiophen-2-yl)methyl]-1-piperazinyl]-thiophen-2-ylmethanone 0
                    [4-(2-pyridinylmethyl)-1-piperazinyl]-thiophen-2-ylmethanone 0
                    [5-[5-[5-(hydroxymethyl)-2-thiophenyl]-2-furanyl]-2-thiophenyl]methanol 0
                    [5-hydroxy-3-(4-methoxyphenyl)-5-(trifluoromethyl)-4H-pyrazol-1-yl]-thiophen-2-ylmethanone 0
                    [[[3-[(4-methylphenyl)methoxy]-2-thiophenyl]-oxomethyl]amino]thiourea 0
                    \{[5-(3-\{[1-(benzylsulfonyl)piperidin-4-yl]amino\}phenyl)-4-bromo-2-(2H-tetrazol-5-yl)thiophen-3-yl]oxy\}acetic acid 0
                    aclidinium + 0
                    arotinolol 1
                    azosemide 1
                    beta-(2-thienyl)-D-alanine 0
                    canagliflozin + 6
                    cefalotin + 15
                    decarboxysuprofen 0
                    decarboxytiaprofenic acid 0
                    dimethenamid OXA 0
                    dimethenamide ESA 0
                    dimethylthiambutene 0
                    dorzolamide + 2
                    duloxetine + 11
                    eprosartan + 5
                    formylthiophene 0
                    hydroxy(phenyl)2-thienylacetic acid 0
                    isofetamid 0
                    methyl 3-[2-(2-thienyl)acetamido]thiophene-2-carboxylate 0
                    necrosulfonamide 0
                    nifurzide 0
                    nocodazole 65
                    pyrantel 1
                    rivaroxaban 8
                    silthiofam 0
                    sufentanil 2
                    suprofen 3
                    taurosteine 0
                    tenidap 2
                    teniposide 22
                    tenocyclidine 0
                    thien-2-ylacetate 0
                    thiencarbazone-methyl 0
                    thienylfentanyl 0
                    thifensulfuron-methyl 0
                    thiophene + 0
                    thiophenecarboxylic acid + 14
                    tiagabine 7
                    tiaprofenic acid 3
                    tienilic acid 5
                    tioxazafen 0
                    tiquizium + 3
                    triarathene 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  organosulfur heterocyclic compound 5834
                                    thiophenes 194
                                      (1E)-2-(5-chlorothiophen-2-yl)-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}prop-1-ene-1-sulfonamide 0
                                      (2,5-Dichlorothiophen-3-yl)methyl N-(pyridin-3-ylmethyl)carbamodithioate 0
                                      (2-amino-5-methyl-3-thiophenyl)-thiophen-2-ylmethanone 0
                                      (2R)-5-methyl-2-\{(1R)-2-oxo-1-[(2-thienylacetyl)amino]ethyl\}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid 0
                                      (2R)-5-methylene-2-\{(1R)-2-oxo-1-[(2-thienylacetyl)amino]ethyl\}-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid 0
                                      (2S)-2-\{(R)-carboxy[(2-thienylacetyl)amino]methyl\}-5-methyl-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid 0
                                      (2S,4S,5R)-2-isobutyl-5-(2-thienyl)-1-[4-(trifluoromethyl)benzoyl]pyrrolidine-2,4-dicarboxylic acid 0
                                      (4R)-4-hydroxy-2-(thien-2-ylmethyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide 0
                                      (4S)-2-\{(R)-carboxy-[(2-thien-2-ylacetyl)amino]methyl\}-5-methylene-5,6-dihydro-4H-1,3-thiazine-4-carboxylic acid 0
                                      (4S)-4-\{[(5-amino-6-oxo-2-thiophen-2-ylpyrimidin-1(6H)-yl)acetyl]amino\}-2,2-difluoro-5-methyl-N-(2-morpholin-4-ylethyl)-3-oxohexanamide 0
                                      (5-bromo-2-thiophenyl)-[4-(3-phenylprop-2-enyl)-1-piperazinyl]methanone 0
                                      (E)-2-(5-chlorothiophen-2-yl)-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}ethenesulfonamide 0
                                      1,3-dimethyl-6-[2-(thiophen-2-ylmethylidene)hydrazinyl]pyrimidine-2,4-dione 0
                                      1,4-bis(thiophen-2-ylsulfonyl)piperazine 0
                                      1-(2-methylphenyl)-3-[[(5-methyl-3-thiophenyl)-oxomethyl]amino]thiourea 0
                                      1-(3-methylphenyl)-3-[[(5-methyl-3-thiophenyl)-oxomethyl]amino]thiourea 0
                                      1-(3-methylphenyl)-3-[[oxo-(5-propyl-3-thiophenyl)methyl]amino]thiourea 0
                                      1-(4-chlorophenyl)-3-[4-methyl-2-(thiophen-2-yl)-1,3-thiazol-5-yl]urea 0
                                      1-(5-nitro-2-thiophenyl)piperidine 0
                                      1-[(2-chlorophenyl)methyl]-3-methyl-N-(4-methyl-2-thiazolyl)-5-thieno[2,3-c]pyrazolecarboxamide 0
                                      1-[(5-bromo-2-thiophenyl)sulfonyl]-3-methylpiperidine 0
                                      1-[[(4-ethyl-5-methyl-3-thiophenyl)-oxomethyl]amino]-3-(2-phenylethyl)thiourea 0
                                      1-\{2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl\}imidazole + 0
                                      1-\{[5-(5-chloro-2-thienyl)isoxazol-3-yl]methyl\}-3-cyano-N-(1-isopropylpiperidin-4-yl)-7-methyl-1H-indole-2-carboxamide 0
                                      1-\{[5-(5-chloro-2-thienyl)isoxazol-3-yl]methyl\}-N-(1-isopropylpiperidin-4-yl)-1H-indole-2-carboxamide 0
                                      1-butyl-3-[[(4,5-dimethyl-3-thiophenyl)-oxomethyl]amino]thiourea 0
                                      1-butyl-3-[[oxo-(5-propan-2-yl-3-thiophenyl)methyl]amino]thiourea 0
                                      1-cyclohexyl-3-[[oxo(thiophen-2-yl)methyl]amino]thiourea 0
                                      1-methyl-N-[2-(4-methylpentan-2-yl)-3-thienyl]-3-(trifluoromethyl)pyrazole-4-carboxamide + 0
                                      2,2'-bithiophenes + 0
                                      2,5-dichloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-3-thiophenecarboxamide 0
                                      2-(2-chlorophenyl)-5-(5-methyl-2-thienyl)-1,3,4-oxadiazole 0
                                      2-(4-\{5-[(1H-benzimidazol-2-ylamino)methyl]thiophen-2-yl\}-1,3-thiazol-2-yl)guanidine 0
                                      2-(5-butylthiophen-2-yl)-2,5-dihydropyrazolo[4,3-c]quinolin-3-one 0
                                      2-(5-chlorothiophen-2-yl)-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}ethanesulfonamide 0
                                      2-(carbamoylamino)-5-(4-fluorophenyl)-3-thiophenecarboxamide 0
                                      2-Pentylthiophene 0
                                      2-Thiophenesulfonamide 0
                                      2-[2-[[2-[(3-carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)amino]-2-oxoethyl]thio]-4-thiazolyl]acetic acid ethyl ester 0
                                      2-[[1-oxo-2-(1H-1,2,4-triazol-5-ylthio)ethyl]amino]-4-thiophen-2-yl-3-thiophenecarboxylic acid ethyl ester 0
                                      2-[[2-[5-(4-morpholinylsulfonyl)-2-thiophenyl]-1-oxoethyl]amino]-5-phenyl-3-thiophenecarboxamide 0
                                      2-[[2-[[4-(2-furanylmethyl)-5-(phenylmethyl)-1,2,4-triazol-3-yl]thio]-1-oxoethyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide 0
                                      2-[[2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]thio]-1-oxoethyl]amino]-3-thiophenecarboxamide 0
                                      2-[[cyclohexyl(oxo)methyl]amino]-3-thiophenecarboxamide 0
                                      2-[[oxo(thiophen-2-yl)methyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid propan-2-yl ester 0
                                      2-[[oxo(thiophen-2-yl)methyl]amino]-6-propyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide 0
                                      2-\{4-[(4-amino-2-methylpyrimidin-5-yl)methyl]-3-methylthiophen-2-yl\}ethyl trihydrogen diphosphate 0
                                      2-amino-5-[diethylamino(oxo)methyl]-4-methyl-3-thiophenecarboxylic acid propan-2-yl ester 0
                                      2-chloro-N-(2,4-dimethylthiophen-3-yl)-N-(1-methoxypropan-2-yl)acetamide + 0
                                      2-chloro-N-[(5-chloro-2-thiophenyl)methyl]-N-methylacetamide 0
                                      2-methylthiophene 0
                                      2-thienylacetic acid + 0
                                      2-thienylacetonitrile 0
                                      3,4-Dimethylthiophene 0
                                      3-(5-butyl-2-thiophenyl)-2-cyano-2-propenethioamide 0
                                      3-(5-ethyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-4-prop-2-enyl-1H-1,2,4-triazole-5-thione 0
                                      3-(5-nitro-2-thiophenyl)-1-(1-pyrrolidinyl)-2-propen-1-one 0
                                      3-(carbamoylamino)-5-(3-fluorophenyl)-N-[(3R)-3-piperidinyl]-2-thiophenecarboxamide 0
                                      3-(carbamoylamino)-5-(3-fluorophenyl)-N-[(3S)-3-piperidinyl]-2-thiophenecarboxamide 0
                                      3-Methylthiophene 0
                                      3-[isopropyl(4-methylbenzoyl)amino]-5-phenylthiophene-2-carboxylic acid 0
                                      3-amino-5-(3-thiophenyl)-2-thiophenecarboxamide 0
                                      3-amino-5-methyl-4-[[3-(4-morpholinyl)propylamino]-oxomethyl]-2-thiophenecarboxylic acid ethyl ester 0
                                      3-chloro-4-propan-2-ylsulfonyl-2-thiophenecarbohydrazide 0
                                      3-ethyl-2-sulfanylidene-5-thiophen-2-yl-1H-thieno[2,3-d]pyrimidin-4-one 0
                                      3-formylthiophene 0
                                      3-methylthiofentanyl + 0
                                      4,5-dimethyl-2-[[oxo(thiophen-2-yl)methyl]amino]-3-thiophenecarboxylic acid ethyl ester 0
                                      4,5-dimethyl-N-(3-thiophenylmethylideneamino)-3-thiophenecarboxamide 0
                                      4,5-dimethyl-N-[[4-(2-methylpropoxy)phenyl]methylideneamino]-3-thiophenecarboxamide 0
                                      4-(2,5-dichlorothiophen-3-yl)pyrimidin-2-amine 0
                                      4-(2-thienyl)butyric acid 0
                                      4-(4-methylpiperazin-1-yl)-N-[5-(2-thienylacetyl)-1,5-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide 0
                                      4-(5-bromo-2-thiophenyl)-6-methyl-2-(1-pyrrolyl)pyrimidine 0
                                      4-(5-ethyl-2-thienyl)-4-oxobutyric acid 0
                                      4-[(5-bromo-2-thiophenyl)methylideneamino]-3-cyclohexyl-1H-1,2,4-triazole-5-thione 0
                                      4-[5-(4-morpholinylsulfonyl)-2-thiophenyl]-3-phenyl-2H-furan-5-one 0
                                      4-[5-amino-3-methyl-4-[oxo-[3-(trifluoromethyl)phenyl]methyl]-2-thiophenyl]butanoic acid 0
                                      4-cyano-3-methyl-5-(4-methylphenyl)-2-thiophenecarbohydrazide 0
                                      4-ethyl-5-methyl-N-[1-[(3-methylphenyl)methyl]-1,2,4-triazol-3-yl]-3-thiophenecarboxamide 0
                                      4-hydroxy-3-(methylthio)-4,5,6,7-tetrahydro-2-benzothiophene-1-carbohydrazide 0
                                      4-oxo-4-(2-thienyl)butyric acid 0
                                      5-(4-chloro-5-phenylthiophen-3-yl)-1,2,5-thiadiazolidin-3-one 1,1-dioxide 0
                                      5-(5-chlorothiophen-2-yl)-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}-1H-1,2,4-triazole-3-sulfonamide 0
                                      5-(methylsulfanyl)-2-(thiophen-2-yl)-3-(trifluoromethyl)pyridine-4-carbonitrile 0
                                      5-[(3-ethoxycarbonyl-4-thiophen-2-yl-2-thiophenyl)amino]-5-oxopentanoic acid 0
                                      5-[(cyclohexylamino)-oxomethyl]-4-methyl-2-[(1-oxo-2-thiophen-2-ylethyl)amino]-3-thiophenecarboxylic acid ethyl ester 0
                                      5-[[3-(1,5-dimethyl-4-pyrazolyl)-1-oxoprop-2-enyl]amino]-3-methylthiophene-2,4-dicarboxylic acid O2-ethyl ester O4-propan-2-yl ester 0
                                      5-[diethylamino(oxo)methyl]-4-methyl-2-(1-oxopentylamino)-3-thiophenecarboxylic acid methyl ester 0
                                      5-amino-3-(4-methoxyphenyl)-7-methyl-4-oxo-1-thieno[3,4-d]pyridazinecarboxylic acid methyl ester 0
                                      5-amino-3-[[[1-(2-furanylmethyl)-5-oxo-3-pyrrolidinyl]-oxomethoxy]methyl]thiophene-2,4-dicarboxylic acid dimethyl ester 0
                                      5-amino-N'-[(3-bromo-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]-4-cyano-3-methyl-2-thiophenecarbohydrazide 0
                                      5-bromo-N-(2-oxolanylmethyl)-2-thiophenesulfonamide 0
                                      5-bromo-N-(2-pyridinylmethyl)-2-thiophenesulfonamide 0
                                      5-bromo-N-(5-cyclohexyl-1,3,4-thiadiazol-2-yl)-2-thiophenecarboxamide 0
                                      5-bromo-N-(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)-2-thiophenecarboxamide 0
                                      5-bromo-N-(pyridin-4-ylmethyl)-2-thiophenesulfonamide 0
                                      5-bromo-N-[2-(4-chlorophenyl)ethyl]-2-thiophenecarboxamide 0
                                      5-bromo-N-[[[oxo(thiophen-2-yl)methyl]hydrazo]-sulfanylidenemethyl]-2-furancarboxamide 0
                                      5-methyl-N-(1-pyridin-4-ylethylideneamino)-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide 0
                                      5-nitro-2-thiophenecarboxylic acid [1-[(3,5-dichloro-2-pyridinyl)amino]-1-oxopropan-2-yl] ester 0
                                      5-nitro-2-thiophenecarboxylic acid [2-oxo-2-(1-phenylethylamino)ethyl] ester 0
                                      5-nitro-2-thiophenecarboxylic acid [2-oxo-2-[(phenylmethyl)amino]ethyl] ester 0
                                      5-nitro-2-thiophenecarboxylic acid [2-oxo-2-[[oxo-[(phenylmethyl)amino]methyl]amino]ethyl] ester 0
                                      6-amino-4-(5-bromo-2-thiophenyl)-3-ethyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile 0
                                      6-methyl-2-[2-[(3-methyl-2-thiophenyl)methylidene]hydrazinyl]-1H-pyrimidin-4-one 0
                                      6-methyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide 0
                                      Arotinolol hydrochloride 0
                                      DuP 697 4
                                      N'-[(3-phenyl-4-pyrazolylidene)methyl]-2-thiophenecarbohydrazide 0
                                      N'-[4-(3-methoxyphenyl)-2-thiazolyl]-2-thiophenecarbohydrazide 0
                                      N,4-dimethyl-5-phenyl-2-thiophenecarboxamide 0
                                      N,N-diethyl-5-thiophen-2-yl-2-thiophenecarboxamide 0
                                      N-(1,3-benzodioxol-5-ylmethyl)-2-[(3-methyl-4-oxo-5-thiophen-2-yl-2-thieno[2,3-d]pyrimidinyl)thio]acetamide 0
                                      N-(1-thiophen-2-ylethylideneamino)-2-thiophenecarboxamide 0
                                      N-(2-furanylmethyl)-5-(4-morpholinyl)-4-phenyl-2-thiophenecarboxamide 0
                                      N-(2-furanylmethyl)-5-methyl-4-phenyl-3-thiophenecarboxamide 0
                                      N-(2-furanylmethylideneamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide 0
                                      N-(2-pyridinyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide 0
                                      N-(2-tert-butyl-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-thiophenecarboxamide 0
                                      N-(3-Methyl-4-nitro-1,2-oxazol-5-yl)-5-[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]thiophene-2-carboxamide 0
                                      N-(3-carbamoyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-methyl-3-pyrazolecarboxamide 0
                                      N-(3-carbamoyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-5-methyl-4-nitro-3-isoxazolecarboxamide 0
                                      N-(3-carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-4-chloro-2-methyl-3-pyrazolecarboxamide 0
                                      N-(3-carbamoyl-5-propyl-2-thiophenyl)-2-methyl-3-furancarboxamide 0
                                      N-(3-carbamoyl-5-propyl-2-thiophenyl)-2-oxolanecarboxamide 0
                                      N-(3-carbamoyl-6-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-3-(2-chlorophenyl)-5-methyl-4-isoxazolecarboxamide 0
                                      N-(3-pyridinyl)-2,3-dihydrothieno[3,4-b][1,4]dioxin-5-carboxamide 0
                                      N-(4-\{[(1H-benzotriazol-1-yl)acetyl][(thiophen-3-yl)methyl]amino\}phenyl)propanamide 0
                                      N-(4-tert-butyl-2-thiazolyl)-5-methyl-2-thiophenecarboxamide 0
                                      N-(6-methoxy-3-pyridinyl)-2-thiophenecarboxamide 0
                                      N-(6-methoxy-3-pyridinyl)-3-methyl-2-thiophenecarboxamide 0
                                      N-[(1S)-2-amino-1-(2,4-dichlorobenzyl)ethyl]-5-[2-(methylamino)pyrimidin-4-yl]thiophene-2-carboxamide 0
                                      N-[(2-bromophenyl)methyl]-2-thiophenecarboxamide 0
                                      N-[(2-ethyl-1-piperidinyl)-sulfanylidenemethyl]-2-thiophenecarboxamide 0
                                      N-[(2-fluorophenyl)methyl]-2-thiophenecarboxamide 0
                                      N-[(2-fluorophenyl)methylideneamino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide 0
                                      N-[(2R,4aR,12aR)-2-[2-[(3-methoxyphenyl)methylamino]-2-oxoethyl]-5-methyl-6-oxo-2,3,4,4a,12,12a-hexahydropyrano[2,3-c][1,5]benzoxazocin-8-yl]-2-thiophenecarboxamide 0
                                      N-[(2R,4aR,12aS)-2-[2-[(3-methoxyphenyl)methylamino]-2-oxoethyl]-5-methyl-6-oxo-2,3,4,4a,12,12a-hexahydropyrano[2,3-c][1,5]benzoxazocin-8-yl]-2-thiophenecarboxamide 0
                                      N-[(2R,4aS,12aR)-2-[2-[(3-methoxyphenyl)methylamino]-2-oxoethyl]-5-methyl-6-oxo-2,3,4,4a,12,12a-hexahydropyrano[2,3-c][1,5]benzoxazocin-8-yl]-2-thiophenecarboxamide 0
                                      N-[(2R,4aS,12aS)-2-[2-[(3-methoxyphenyl)methylamino]-2-oxoethyl]-5-methyl-6-oxo-2,3,4,4a,12,12a-hexahydropyrano[2,3-c][1,5]benzoxazocin-8-yl]-2-thiophenecarboxamide 0
                                      N-[(2S,4aR,12aR)-2-[2-[(3-methoxyphenyl)methylamino]-2-oxoethyl]-5-methyl-6-oxo-2,3,4,4a,12,12a-hexahydropyrano[2,3-c][1,5]benzoxazocin-8-yl]-2-thiophenecarboxamide 0
                                      N-[(2S,4aR,12aS)-2-[2-[(3-methoxyphenyl)methylamino]-2-oxoethyl]-5-methyl-6-oxo-2,3,4,4a,12,12a-hexahydropyrano[2,3-c][1,5]benzoxazocin-8-yl]-2-thiophenecarboxamide 0
                                      N-[(2S,4aS,12aR)-2-[2-[(3-methoxyphenyl)methylamino]-2-oxoethyl]-5-methyl-6-oxo-2,3,4,4a,12,12a-hexahydropyrano[2,3-c][1,5]benzoxazocin-8-yl]-2-thiophenecarboxamide 0
                                      N-[(2S,4aS,12aS)-2-[2-[(3-methoxyphenyl)methylamino]-2-oxoethyl]-5-methyl-6-oxo-2,3,4,4a,12,12a-hexahydropyrano[2,3-c][1,5]benzoxazocin-8-yl]thiophene-2-carboxamide 0
                                      N-[(3,5,5-trimethyl-1-cyclohex-2-enylidene)amino]-2-thiophenecarboxamide 0
                                      N-[(3-fluorophenyl)methylideneamino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide 0
                                      N-[(3-methyl-2-thiophenyl)methylideneamino]-2-thiophenecarboxamide 0
                                      N-[(5-\{2-[(6R)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl]ethyl\}thiophen-2-yl)carbonyl]-L-glutamic acid 0
                                      N-[(5-acetyl-3-thienyl)methyl]-2-chloroacetamide semicarbazone 0
                                      N-[(5R)-5-(3,4-dichlorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]thiophene-2-sulfonamide 0
                                      N-[(R)-[(1R,2R)-2-butylcyclopropyl]-(4-chlorophenyl)methyl]-2-thiophenecarboxamide 0
                                      N-[1-methyl-3-(trifluoromethyl)-5-thieno[2,3-c]pyrazolyl]carbamic acid 2,2-dimethylpropyl ester 0
                                      N-[2,2-dimethyl-3-[[oxo(thiophen-2-yl)methyl]amino]propyl]-2-thiophenecarboxamide 0
                                      N-[2-(4-fluorophenyl)ethyl]-5-methyl-2-thiophenecarboxamide 0
                                      N-[2-(cyclohexylamino)-2-oxo-1-thiophen-2-ylethyl]-2,2,2-trifluoro-N-(4-methylphenyl)acetamide 0
                                      N-[3-(3,5-dimethyl-1-piperidinyl)propyl]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide 0
                                      N-[3-[(cyclopropylamino)-oxomethyl]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophen-2-yl]-2-furancarboxamide 0
                                      N-[3-[oxo-(3-pyridinylmethylamino)methyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-2-furancarboxamide 0
                                      N-[3-carbamoyl-5-[diethylamino(oxo)methyl]-4-methyl-2-thiophenyl]carbamic acid methyl ester 0
                                      N-[5-(2,3-dihydro-1,4-dioxin-5-yl)-1,3,4-oxadiazol-2-yl]-5-nitro-2-thiophenecarboxamide 0
                                      N-[5-(2-oxolanyl)-1,3,4-thiadiazol-2-yl]-2-thiophenecarboxamide 0
                                      N-[5-(3-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-thiophenecarboxamide 0
                                      N-[5-[(4-chlorophenoxy)methyl]-1,3,4-thiadiazol-2-yl]-2-thiophenecarboxamide 0
                                      N-[[(5-chloro-2-pyridinyl)amino]-sulfanylidenemethyl]-2-thiophenecarboxamide 0
                                      N-[cyano(2-thienyl)methyl]-4-ethyl-2-(ethylamino)-1,3-thiazole-5-carboxamide + 0
                                      N-\{3-[4-(3-aminopropyl)piperazin-1-yl]propyl\}-3-(2-thiophen-2-ylacetylamino)-5-(3,4,5-trihydroxy-6-hydroxymethyltetrahydropyran-2-yloxy)benzamide 0
                                      N-\{4-[(1H-benzotriazol-1-ylacetyl)(thiophen-3-ylmethyl)amino]phenyl\}-2-methylpropanamide 0
                                      N-\{[5-(1-benzofuran-2-yl)thiophen-2-yl]methyl\}-N-[(2,4-dichlorophenyl)carbonyl]-L-phenylalanine 0
                                      N-butyl-N(2)-(2-thienylacetyl)-L-alaninamide 0
                                      N-butyl-N(2)-(2-thienylacetyl)-L-cysteinamide 0
                                      N-butyl-N(2)-(2-thienylacetyl)-L-serinamide 0
                                      N-ethyl-3-(1-pyrrolyl)-2-thiophenecarboxamide 0
                                      N-methyl-5-phenyl-2-thiophenecarboxamide 0
                                      N-propyl-N-(5-pyridin-4-yl-1,3,4-thiadiazol-2-yl)-2-thiophenecarboxamide 0
                                      OSMI-1 0
                                      [1-(4,5-diphenyl-2-thiophenyl)ethylideneamino]thiourea 0
                                      [3,5-bis[(phenylmethyl)amino]-1,2,4-triazol-1-yl]-thiophen-2-ylmethanone 0
                                      [3-(2-furanyl)-5-(phenylmethylthio)-1,2,4-triazol-1-yl]-thiophen-2-ylmethanone 0
                                      [3-(2-hydroxyphenyl)-5-(4-methoxyphenyl)-3,4-dihydropyrazol-2-yl]-thiophen-2-ylmethanone 0
                                      [3-methyl-4-[oxo(thiophen-2-yl)methyl]-1-piperazinyl]-thiophen-2-ylmethanone 0
                                      [4-(2-pyridinylmethyl)-1-piperazinyl]-thiophen-2-ylmethanone 0
                                      [5-[5-[5-(hydroxymethyl)-2-thiophenyl]-2-furanyl]-2-thiophenyl]methanol 0
                                      [5-hydroxy-3-(4-methoxyphenyl)-5-(trifluoromethyl)-4H-pyrazol-1-yl]-thiophen-2-ylmethanone 0
                                      [[[3-[(4-methylphenyl)methoxy]-2-thiophenyl]-oxomethyl]amino]thiourea 0
                                      \{[5-(3-\{[1-(benzylsulfonyl)piperidin-4-yl]amino\}phenyl)-4-bromo-2-(2H-tetrazol-5-yl)thiophen-3-yl]oxy\}acetic acid 0
                                      aclidinium + 0
                                      arotinolol 1
                                      azosemide 1
                                      beta-(2-thienyl)-D-alanine 0
                                      canagliflozin + 6
                                      cefalotin + 15
                                      decarboxysuprofen 0
                                      decarboxytiaprofenic acid 0
                                      dimethenamid OXA 0
                                      dimethenamide ESA 0
                                      dimethylthiambutene 0
                                      dorzolamide + 2
                                      duloxetine + 11
                                      eprosartan + 5
                                      formylthiophene 0
                                      hydroxy(phenyl)2-thienylacetic acid 0
                                      isofetamid 0
                                      methyl 3-[2-(2-thienyl)acetamido]thiophene-2-carboxylate 0
                                      necrosulfonamide 0
                                      nifurzide 0
                                      nocodazole 65
                                      pyrantel 1
                                      rivaroxaban 8
                                      silthiofam 0
                                      sufentanil 2
                                      suprofen 3
                                      taurosteine 0
                                      tenidap 2
                                      teniposide 22
                                      tenocyclidine 0
                                      thien-2-ylacetate 0
                                      thiencarbazone-methyl 0
                                      thienylfentanyl 0
                                      thifensulfuron-methyl 0
                                      thiophene + 0
                                      thiophenecarboxylic acid + 14
                                      tiagabine 7
                                      tiaprofenic acid 3
                                      tienilic acid 5
                                      tioxazafen 0
                                      tiquizium + 3
                                      triarathene 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.