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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tetracyclines
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Accession:CHEBI:26895 term browser browse the term
Definition:A subclass of polyketides having an octahydrotetracene-2-carboxamide skeleton, substituted with many hydroxy and other groups.
Synonyms:xref_mesh: MESH:D013754


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tetracyclines term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mmp9 matrix metallopeptidase 9 decreases activity EXP Tetracyclines results in decreased activity of MMP9 protein CTD PMID:11172685 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
chlortetracycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity ISO Chlortetracycline results in decreased activity of CAT protein CTD PMID:30768968 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Chlortetracycline inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
demeclocycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1a interleukin 1 alpha multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Demeclocycline CTD PMID:19362101 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Demeclocycline CTD PMID:19362101 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Demeclocycline CTD PMID:19362101 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
doxycycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression EXP Doxycycline results in decreased expression of ABCB11 mRNA CTD PMID:27765674 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression ISO Doxycycline results in decreased expression of ABCB1 protein CTD PMID:11147995 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression EXP Doxycycline results in decreased expression of ABCB4 mRNA CTD PMID:27765674 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 decreases expression EXP Doxycycline results in decreased expression of ABCC3 mRNA CTD PMID:27765674 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 decreases expression EXP Doxycycline results in decreased expression of ABCC4 mRNA CTD PMID:27765674 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression EXP Doxycycline results in increased expression of ABCG5 mRNA CTD PMID:27765674 NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in decreased expression of ACTA2 mRNA] CTD PMID:18089841 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Ada adenosine deaminase multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of ADA mRNA] CTD PMID:18089841 NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947
JBrowse link
G Agt angiotensinogen multiple interactions EXP Doxycycline inhibits the reaction [AGT protein modified form results in increased activity of MMP2 protein]; Doxycycline inhibits the reaction [AGT protein modified form results in increased activity of MMP9 protein] CTD PMID:20837116 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases expression
ISO [[Doxycycline results in increased expression of AHR protein] which co-treated with Tobacco Smoke Pollution] results in increased expression of CYP1B1 mRNA
[Doxycycline results in increased expression of AHR protein] which results in increased expression of CYP1B1 mRNA; Doxycycline results in increased expression of AHR protein
CTD PMID:22273977 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ang angiogenin multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of ANG mRNA] CTD PMID:18089841 NCBI chr15:28,022,926...28,028,636 JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased phosphorylation of ATF2 protein] CTD PMID:18089841 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO Doxycycline inhibits the reaction [Doxorubicin results in increased expression of BAD protein] CTD PMID:17673183 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Doxycycline inhibits the reaction [Doxorubicin results in increased expression of BAX protein] CTD PMID:17673183 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Doxycycline inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein] CTD PMID:17673183 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO Doxycycline inhibits the reaction [Doxorubicin results in decreased expression of BCL2L1 protein] CTD PMID:17673183 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Doxycycline inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Doxycycline inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein] CTD PMID:17673183 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccng2 cyclin G2 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of CCNG2 mRNA] CTD PMID:18089841 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of CDKN1A mRNA] CTD PMID:18089841 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression
ISO [[Doxycycline results in increased expression of AHR protein] which co-treated with Tobacco Smoke Pollution] results in increased expression of CYP1B1 mRNA
[Doxycycline results in increased expression of AHR protein] which results in increased expression of CYP1B1 mRNA
CTD PMID:22273977 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of DDIT4 mRNA] CTD PMID:18089841 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of FOS mRNA] CTD PMID:18089841 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gem GTP binding protein overexpressed in skeletal muscle multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of GEM mRNA] CTD PMID:18089841 NCBI chr 5:25,339,479...25,353,661
Ensembl chr 5:25,349,928...25,353,661
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in decreased expression of GJA1 mRNA] CTD PMID:18089841 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Doxycycline inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Doxycycline analog inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA] CTD PMID:17267227 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Doxycycline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:25977597 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of LCN2 mRNA] CTD PMID:18089841 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Map3k6 mitogen-activated protein kinase kinase kinase 6 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MAP3K6 mRNA] CTD PMID:18089841 NCBI chr 5:151,435,679...151,448,329
Ensembl chr 5:151,436,464...151,448,328
JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MAP3K8 mRNA] CTD PMID:18089841 NCBI chr17:56,109,403...56,129,925
Ensembl chr17:56,109,549...56,129,919
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK14 protein] CTD PMID:18089841 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions
increases expression
decreases activity
ISO Doxycycline analog inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]
Doxycycline results in increased expression of MMP13 mRNA
Doxycycline analog results in decreased activity of MMP13 protein
CTD PMID:17267227, PMID:20338993 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases activity
decreases expression
ISO
EXP
Doxycycline inhibits the reaction [Isoproterenol results in increased activity of MMP2]
Doxycycline results in decreased activity of MMP2 protein
Doxycycline inhibits the reaction [AGT protein modified form results in increased activity of MMP2 protein]; Doxycycline inhibits the reaction [Lead results in increased expression of and results in increased activity of MMP2 protein]
Doxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP2 protein]; Doxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein]
Doxycycline results in decreased expression of MMP2 protein
Doxycycline analog results in decreased activity of MMP2 protein
CTD PMID:17267227, PMID:17498959, PMID:18089841, PMID:18178469, PMID:18836702, PMID:19375915, PMID:20837116 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions
decreases activity
ISO Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MMP3 mRNA]
Doxycycline results in decreased activity of MMP3 protein
CTD PMID:17267227, PMID:18089841 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mmp8 matrix metallopeptidase 8 decreases activity ISO Doxycycline analog results in decreased activity of MMP8 protein CTD PMID:17267227 NCBI chr 8:5,768,808...5,777,741
Ensembl chr 8:5,768,811...5,778,702
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases activity
decreases expression
ISO
EXP
Doxycycline inhibits the reaction [Isoproterenol results in increased activity of MMP9]; Doxycycline inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 mRNA]; Doxycycline inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 protein]
Doxycycline results in decreased activity of MMP9 protein
Doxycycline inhibits the reaction [AGT protein modified form results in increased activity of MMP9 protein]
Doxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]; Doxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]
Doxycycline results in decreased expression of MMP9 protein
CTD PMID:15131573, PMID:17498959, PMID:18089841, PMID:18178469, PMID:19375915, PMID:20837116 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MT2 mRNA] CTD PMID:18089841 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MYH7 mRNA] CTD PMID:18089841 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
ISO Doxycycline results in decreased stability of and results in decreased expression of NOS2 mRNA
Doxycycline results in decreased expression of NOS2 protein
CTD PMID:16365451 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of NOX4 mRNA] CTD PMID:18089841 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Osmr oncostatin M receptor multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of OSMR mRNA] CTD PMID:18089841 NCBI chr 2:56,107,491...56,163,522
Ensembl chr 2:56,110,777...56,151,531
JBrowse link
G Pla2g7 phospholipase A2 group VII multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of PLA2G7 mRNA] CTD PMID:18089841 NCBI chr 9:19,935,754...19,978,013
Ensembl chr 9:19,935,768...19,978,013
JBrowse link
G S100a8 S100 calcium binding protein A8 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of S100A8 mRNA] CTD PMID:18089841 NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354
JBrowse link
G S100a9 S100 calcium binding protein A9 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of S100A9 mRNA] CTD PMID:18089841 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of S1PR1 mRNA]; Doxycycline inhibits the reaction [Isoproterenol results in increased expression of S1PR1 protein] CTD PMID:18089841 NCBI chr 2:218,654,406...218,658,761
Ensembl chr 2:218,654,554...218,658,761
JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of SERPINA3N mRNA] CTD PMID:18089841 NCBI chr 6:128,073,344...128,080,878
Ensembl chr 6:127,941,526...128,080,889
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP Doxycycline results in decreased expression of SLC10A1 mRNA CTD PMID:27765674 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Doxycycline inhibits the reaction [SLC22A6 protein results in increased uptake of Anions] CTD PMID:11855680 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Smyd1 SET and MYND domain containing 1 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in decreased expression of SMYD1 mRNA] CTD PMID:18089841 NCBI chr 4:99,071,122...99,125,143
Ensembl chr 4:99,074,535...99,125,111
JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of SOCS3 mRNA] CTD PMID:18089841 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO Doxycycline inhibits the reaction [Doxorubicin results in decreased expression of SOD1 protein] CTD PMID:17673183 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Tardbp TAR DNA binding protein multiple interactions
decreases expression
ISO [Doxycycline analog results in decreased expression of TARDBP protein] inhibits the reaction [sodium arsenite affects the localization of TARDBP protein] CTD PMID:24019256 NCBI chr 5:165,432,089...165,442,232
Ensembl chr 5:165,432,095...165,442,048
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of TGFBR2 mRNA] CTD PMID:18089841 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Doxycycline inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of TNF protein]; Doxycycline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:16134060, PMID:25977597 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of TRP53INP1 mRNA] CTD PMID:18089841 NCBI chr 5:24,402,895...24,419,651
Ensembl chr 5:24,410,863...24,416,888
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases expression
multiple interactions
ISO Doxycycline results in increased expression of UGT1A8 mRNA
Doxycycline promotes the reaction [Tobacco Smoke Pollution results in increased expression of UGT1A8 mRNA]
CTD PMID:22273977 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
meclocycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO meclocycline results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO meclocycline results in decreased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO meclocycline results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO meclocycline results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO meclocycline results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO meclocycline results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
minocycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions
decreases secretion
EXP
ISO
Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of and results in increased localization of AIFM1 protein]
Minocycline results in decreased secretion of AIFM1 protein
Minocycline inhibits the reaction [Kainic Acid results in increased localization of AIFM1 protein]
CTD PMID:12930891, PMID:16469440 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO
EXP
Minocycline inhibits the reaction [APP gene mutant form results in increased phosphorylation of EIF2S1 protein]
Minocycline inhibits the reaction [APP protein alternative form results in increased activity of CASP12 protein]; Minocycline inhibits the reaction [APP protein alternative form results in increased phosphorylation of EIF2AK2 protein]; Minocycline inhibits the reaction [APP protein alternative form results in increased phosphorylation of EIF2S1 protein]
CTD PMID:17406652 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Atf3 activating transcription factor 3 multiple interactions EXP Minocycline inhibits the reaction [Paclitaxel results in increased expression of ATF3 protein] CTD PMID:21050491 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions EXP Minocycline inhibits the reaction [Paraquat results in increased expression of ATF6 protein] CTD PMID:22245251 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha multiple interactions ISO Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP5A1 protein] CTD PMID:23562983 NCBI chr18:74,156,553...74,164,490
Ensembl chr18:74,156,553...74,164,495
JBrowse link
G Atp5pd ATP synthase peripheral stalk subunit d multiple interactions EXP Minocycline inhibits the reaction [cypermethrin results in decreased expression of ATP5H protein] CTD PMID:21561882 NCBI chr10:103,967,340...103,972,552
Ensembl chr10:103,967,312...103,972,668
JBrowse link
G Bace1 beta-secretase 1 multiple interactions ISO Minocycline inhibits the reaction [Copper results in increased expression of BACE1 mRNA] CTD PMID:18583042 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions EXP [Minocycline results in increased expression of BCL2 protein] which binds to BAK1 protein CTD PMID:15004018 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
decreases expression
EXP [Minocycline results in increased expression of BCL2 protein] which binds to BAX protein; Minocycline inhibits the reaction [Sodium Azide affects the localization of BAX protein]
Minocycline results in decreased expression of BAX protein
CTD PMID:15004018, PMID:15172883 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
ISO
EXP
[Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2 protein] results in increased expression of BCL2 mRNA; [Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of BCL2 protein
Minocycline results in increased expression of BCL2 mRNA; Minocycline results in increased expression of BCL2 protein
[Minocycline results in increased expression of BCL2 protein] which binds to BAK1 protein; [Minocycline results in increased expression of BCL2 protein] which binds to BAX protein; [Minocycline results in increased expression of BCL2 protein] which binds to BID protein; Sodium Azide inhibits the reaction [Minocycline results in increased expression of BCL2 protein]
CTD PMID:15004018, PMID:19807907, PMID:20606027, PMID:20711699 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO
EXP
Minocycline results in decreased activity of and results in decreased cleavage of BID protein
[Minocycline results in increased expression of BCL2 protein] which binds to BID protein; Minocycline inhibits the reaction [HTT protein mutant form results in increased cleavage of and results in increased activity of BID protein]
CTD PMID:12930891, PMID:15004018 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Casp1 caspase 1 multiple interactions
decreases expression
decreases activity
EXP
ISO
Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP1 protein]
Minocycline results in decreased expression of CASP1 mRNA; Minocycline results in decreased expression of CASP1 protein
Minocycline results in decreased activity of CASP1 protein
CTD PMID:12930891, PMID:14998631 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp12 caspase 12 multiple interactions
decreases expression
EXP Minocycline inhibits the reaction [APP protein alternative form results in increased activity of CASP12 protein]; Minocycline results in decreased degradation of [Paraquat results in increased expression of CASP12 protein]
Minocycline results in decreased expression of CASP12 mRNA; Minocycline results in decreased expression of CASP12 protein
CTD PMID:14998631, PMID:17406652, PMID:22245251 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp3 caspase 3 decreases activity
decreases expression
multiple interactions
ISO
EXP
Minocycline results in decreased activity of CASP3 protein
Minocycline results in decreased expression of CASP3 mRNA
Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP3 protein]; Minocycline inhibits the reaction [Morphine results in increased activity of CASP3 protein]; Minocycline inhibits the reaction [Paraquat results in increased cleavage of CASP3 protein]; Minocycline inhibits the reaction [Sodium Azide results in increased activity of CASP3 protein]; Minocycline results in decreased expression of and results in decreased activity of CASP3 protein
Minocycline inhibits the reaction [Kainic Acid results in increased activity of CASP3 protein]; Minocycline results in decreased activity of and results in decreased cleavage of CASP3 protein
CTD PMID:12930891, PMID:14588118, PMID:14998631, PMID:15004018, PMID:15304547, PMID:15564845, PMID:16469440, PMID:17872917, PMID:20711699, PMID:22245251 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 decreases expression
multiple interactions
EXP Minocycline results in decreased expression of CASP7 mRNA
Minocycline results in decreased expression of and results in decreased activity of CASP7 protein
CTD PMID:14998631 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions
decreases expression
EXP Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP8 protein]; Minocycline results in decreased expression of and results in decreased activity of CASP8 protein
Minocycline results in decreased expression of CASP8 mRNA
CTD PMID:12930891, PMID:14998631 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 decreases activity
decreases expression
multiple interactions
ISO
EXP
Minocycline results in decreased activity of CASP9 protein
Minocycline results in decreased expression of CASP9 mRNA
Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP9 protein]; Minocycline results in decreased expression of and results in decreased activity of CASP9 protein
CTD PMID:12930891, PMID:14998631 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions
ISO Minocycline results in decreased expression of CCL2 protein
Minocycline inhibits the reaction [lead acetate results in increased secretion of CCL2 protein]
CTD PMID:20116850, PMID:24530660 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO Minocycline results in decreased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Minocycline results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Minocycline results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Minocycline results in increased expression of CDKN1B mRNA; Minocycline results in increased expression of CDKN1B protein CTD PMID:21719015 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cldn5 claudin 5 increases expression EXP minocycline increases expression of claudin-5 protein in left corpus callosum of rats with right carotid artery occlusion RGD PMID:29486300 RGD:27095946 NCBI chr11:86,356,292...86,357,718
Ensembl chr11:86,356,294...86,357,718
JBrowse link
G Cox5a cytochrome c oxidase subunit 5A multiple interactions ISO Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX5A protein] CTD PMID:23562983 NCBI chr 8:62,298,358...62,309,765
Ensembl chr 8:62,298,358...62,309,765
JBrowse link
G Cycs cytochrome c, somatic multiple interactions
decreases secretion
ISO
EXP
Minocycline inhibits the reaction [Kainic Acid results in increased localization of CYCS protein]
Minocycline results in decreased secretion of CYCS protein
Minocycline inhibits the reaction [Cocaine results in increased secretion of CYCS protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of CYCS protein]
CTD PMID:12930891, PMID:14998631, PMID:15172883, PMID:16469440, PMID:21424555 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP Minocycline inhibits the reaction [Paraquat results in increased expression of DDIT3 protein] CTD PMID:22245251 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein decreases secretion
multiple interactions
ISO
EXP
Minocycline results in decreased secretion of DIABLO protein
Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of DIABLO protein]; Minocycline results in decreased secretion of and results in decreased expression of DIABLO protein
CTD PMID:12930891, PMID:14998631 NCBI chr12:38,490,230...38,503,344
Ensembl chr12:38,490,230...38,503,330
JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase multiple interactions ISO Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DLST protein] CTD PMID:23562983 NCBI chr 6:108,936,534...108,961,322
Ensembl chr 6:108,936,664...108,959,803
JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 multiple interactions
increases expression
ISO [[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] inhibits the reaction [Oxygen deficiency results in increased stability of HIF1A protein]; [[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] results in increased degradation of HIF1A protein CTD PMID:24292262 NCBI chr19:57,660,194...57,701,158
Ensembl chr19:57,662,278...57,699,113
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 multiple interactions EXP Minocycline inhibits the reaction [APP protein alternative form results in increased phosphorylation of EIF2AK2 protein] CTD PMID:17406652 NCBI chr 6:1,428,845...1,466,193
Ensembl chr 6:1,428,834...1,466,201
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation EXP Minocycline results in increased phosphorylation of EIF2AK3 protein CTD PMID:22245251 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions
increases phosphorylation
ISO
EXP
Minocycline inhibits the reaction [APP gene mutant form results in increased phosphorylation of EIF2S1 protein]
Minocycline results in increased phosphorylation of EIF2S1 protein
Minocycline inhibits the reaction [APP protein alternative form results in increased phosphorylation of EIF2S1 protein]
CTD PMID:17406652, PMID:22245251 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Eno1 enolase 1 multiple interactions ISO Minocycline inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ENO1 protein]; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of ENO1 protein] CTD PMID:23562983 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases phosphorylation EXP Minocycline results in increased phosphorylation of ERN1 protein CTD PMID:22245251 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Fmr1 FMRP translational regulator 1 multiple interactions ISO Minocycline inhibits the reaction [FMR1 gene mutant form results in increased expression of and results in increased activity of MMP9 protein] CTD PMID:18835858 NCBI chr  X:154,684,924...154,722,369
Ensembl chr  X:154,684,935...154,722,314
JBrowse link
G Gjc2 gap junction protein, gamma 2 multiple interactions EXP Minocycline inhibits the reaction [cypermethrin results in increased expression of GJC2 protein modified form] CTD PMID:21561882 NCBI chr10:45,526,740...45,535,520
Ensembl chr10:45,526,745...45,534,570
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions EXP Minocycline inhibits the reaction [Poly C results in increased expression of GRIA1 mRNA] CTD PMID:19660546 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions EXP Minocycline inhibits the reaction [Poly C results in increased expression of GRIN2A mRNA] CTD PMID:19660546 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C multiple interactions EXP Minocycline inhibits the reaction [Poly C results in increased expression of GRIN2C mRNA] CTD PMID:19660546 NCBI chr10:103,798,290...103,816,923
Ensembl chr10:103,798,291...103,816,287
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP minocycline increases expression of glutathione S-transferase pi protein in left corpus callosum of rats with right carotid artery occlusion RGD PMID:29486300 RGD:27095946 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases degradation
ISO [[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] inhibits the reaction [Oxygen deficiency results in increased stability of HIF1A protein]; [[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] results in increased degradation of HIF1A protein; Minocycline inhibits the reaction [Oxygen deficiency results in increased stability of HIF1A protein]; Minocycline promotes the reaction [HIF1A protein binds to VHL protein]
Minocycline results in increased degradation of HIF1A protein
CTD PMID:24292262 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hp haptoglobin increases expression EXP minocycline increases expression of zonulin protein in left corpus callosum of rats with right carotid artery occlusion RGD PMID:29486300 RGD:27095946 NCBI chr19:42,096,255...42,100,805
Ensembl chr19:42,097,995...42,100,804
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Minocycline inhibits the reaction [Paraquat results in increased expression of HSPA5 protein] CTD PMID:22245251 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions EXP Minocycline inhibits the reaction [cypermethrin results in increased expression of HSPD1 protein] CTD PMID:21561882 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Htt huntingtin multiple interactions EXP Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP1 protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP3 protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP8 protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP9 protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased cleavage of and results in increased activity of BID protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of and results in increased localization of AIFM1 protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of CYCS protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of DIABLO protein] CTD PMID:12930891 NCBI chr14:81,105,139...81,254,637
Ensembl chr14:81,105,139...81,254,637
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression EXP Minocycline results in decreased expression of ICAM1 protein CTD PMID:15172883 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma multiple interactions ISO Minocycline inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG mRNA]
[Minocycline co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA
CTD PMID:19285099, PMID:29594315 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression
ISO
EXP
Minocycline promotes the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA]
Minocycline results in increased expression of IL10 mRNA
CTD PMID:14588118, PMID:22024136 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions
affects secretion
ISO
EXP
Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; Minocycline inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
Minocycline inhibits the reaction [Kainic Acid results in increased secretion of IL1B protein]; Minocycline inhibits the reaction [lead acetate results in increased secretion of IL1B protein]; Minocycline inhibits the reaction [manganese chloride results in increased expression of IL1B protein]; Minocycline inhibits the reaction [Toluene results in increased expression of IL1B mRNA]
Minocycline affects the secretion of IL1B protein
CTD PMID:11306611, PMID:16386803, PMID:18836210, PMID:19285099, PMID:22024136, PMID:22952811, PMID:32234516 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Minocycline co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of IL6 mRNA]; Minocycline inhibits the reaction [Dietary Fats results in increased expression of IL6 protein]; Minocycline inhibits the reaction [lead acetate results in increased secretion of IL6 protein] CTD PMID:19285099, PMID:21719015, PMID:24530660 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Minocycline results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Ina internexin neuronal intermediate filament protein, alpha multiple interactions EXP Minocycline inhibits the reaction [cypermethrin results in increased expression of INA protein] CTD PMID:21561882 NCBI chr 1:266,782,835...266,794,389
Ensembl chr 1:266,781,617...266,794,431
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Minocycline results in decreased phosphorylation of and results in decreased activity of and results in decreased expression of JUN protein CTD PMID:17872917 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G LOC100364500 RT1 class I, locus CE11-like affects expression ISO Minocycline affects the expression of HLA-A mRNA CTD PMID:25811541 NCBI chr20:2,704,153...2,707,111
Ensembl chr20:2,704,148...2,707,120
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases phosphorylation ISO Minocycline results in decreased phosphorylation of MAPK8 protein CTD PMID:17872917 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapkapk5 MAPK activated protein kinase 5 multiple interactions EXP Minocycline inhibits the reaction [cypermethrin results in increased expression of MAPKAPK5 protein] CTD PMID:21561882 NCBI chr12:40,510,378...40,529,332
Ensembl chr12:40,510,378...40,529,338
JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression
multiple interactions
ISO Minocycline results in increased expression of MMP13 mRNA
Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP13 mRNA]
CTD PMID:19285099, PMID:20338993 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
multiple interactions
decreases activity
ISO
EXP
Minocycline results in decreased expression of MMP2 protein
Minocycline inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 mRNA]
Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP2 mRNA]; Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP2 protein]
Minocycline results in decreased activity of MMP2 protein
CTD PMID:11835378, PMID:14508231, PMID:16846501, PMID:19285099, PMID:24292262 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP3 mRNA] CTD PMID:19285099 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases activity
decreases expression
ISO
EXP
Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP9 mRNA]; Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP9 protein]; Minocycline inhibits the reaction [FMR1 gene mutant form results in increased expression of and results in increased activity of MMP9 protein]
Minocycline results in decreased activity of MMP9 protein
Minocycline results in decreased expression of MMP9 protein
CTD PMID:16846501, PMID:18835858, PMID:19285099 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO Minocycline affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:72,771,992...72,789,861
Ensembl chr13:72,771,984...72,789,841
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of NOS2 mRNA]; Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of NOS2 protein]; Minocycline inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA]
Minocycline inhibits the reaction [lead acetate results in increased expression of NOS2 protein]; Minocycline inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Minocycline inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Minocycline inhibits the reaction [manganese chloride results in increased expression of NOS2 protein]
CTD PMID:15485488, PMID:18836210, PMID:19285099, PMID:22952811 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ocln occludin increases expression EXP minocycline increases expression of occludin protein in left corpus callosum of rats with right carotid artery occlusion RGD PMID:29486300 RGD:27095946 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G Pafah1b2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 multiple interactions EXP Minocycline inhibits the reaction [cypermethrin results in decreased expression of PAFAH1B2 protein] CTD PMID:21561882 NCBI chr 8:50,256,969...50,310,043
Ensembl chr 8:50,259,248...50,277,797
JBrowse link
G Prdx2 peroxiredoxin 2 multiple interactions ISO Minocycline inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PRDX2 protein] CTD PMID:23562983 NCBI chr19:26,084,816...26,090,095
Ensembl chr19:26,084,903...26,090,094
JBrowse link
G Prdx3 peroxiredoxin 3 multiple interactions ISO Minocycline inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PRDX3 protein]; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PRDX3 protein] CTD PMID:23562983 NCBI chr 1:282,238,774...282,251,193
Ensembl chr 1:282,238,773...282,251,257
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO Minocycline inhibits the reaction [PRKN gene mutant form results in increased susceptibility to Rotenone] CTD PMID:16573651 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Prtn3 proteinase 3 increases expression ISO Minocycline results in increased expression of PRTN3 protein CTD PMID:12900849 NCBI chr 7:12,643,712...12,646,951
Ensembl chr 7:12,643,516...12,646,960
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions EXP Minocycline inhibits the reaction [Morphine results in increased expression of PTGS1 mRNA] CTD PMID:18706994 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects expression ISO Minocycline affects the expression of RELA protein CTD PMID:17898303 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G RT1-CE5 RT1 class I, locus CE5 affects expression ISO Minocycline affects the expression of HLA-F mRNA CTD PMID:25811541 NCBI chr20:4,892,702...4,896,993
Ensembl chr20:4,892,702...4,896,991
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Minocycline inhibits the reaction [SLC22A6 protein results in increased uptake of Anions] CTD PMID:11855680 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO Minocycline inhibits the reaction [SLC22A7 protein results in increased uptake of Anions] CTD PMID:11855680 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO Minocycline inhibits the reaction [Oxygen deficiency results in increased expression of SLC2A1 mRNA] CTD PMID:24292262 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO Minocycline inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein] CTD PMID:16839653 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Snap25 synaptosome associated protein 25 multiple interactions EXP Minocycline inhibits the reaction [cypermethrin results in decreased expression of SNAP25 protein] CTD PMID:21561882 NCBI chr 3:129,697,408...129,788,417
Ensembl chr 3:129,599,353...129,788,400
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SOD2 protein] CTD PMID:23562983 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Stmn1 stathmin 1 multiple interactions EXP
ISO
Minocycline inhibits the reaction [cypermethrin results in decreased expression of STMN1 protein]
Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STMN1 protein]
CTD PMID:21561882, PMID:23562983 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions
EXP Minocycline results in increased expression of TGFB1 mRNA
Minocycline inhibits the reaction [Toluene results in decreased expression of TGFB1 mRNA]
CTD PMID:32234516 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions ISO [Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2 protein] results in increased expression of BCL2 mRNA; [Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of BCL2 protein; [Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of XIAP mRNA; [Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of XIAP protein CTD PMID:20606027 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
EXP
ISO
Minocycline inhibits the reaction [lead acetate results in increased secretion of TNF protein]; Minocycline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Minocycline inhibits the reaction [manganese chloride results in increased expression of TNF protein]
Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of TNF mRNA]; Minocycline inhibits the reaction [Dietary Fats results in increased expression of TNF protein]; Minocycline inhibits the reaction [lead acetate results in increased secretion of TNF protein]; Minocycline inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]
Minocycline results in decreased expression of TNF mRNA
CTD PMID:14588118, PMID:15485488, PMID:18836210, PMID:19285099, PMID:21719015, PMID:22952811, PMID:24530660 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 decreases expression EXP Minocycline results in decreased expression of TP53 protein CTD PMID:15172883 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpo thyroid peroxidase decreases activity EXP Minocycline results in decreased activity of TPO protein CTD PMID:26884060 NCBI chr 6:49,020,918...49,089,855
Ensembl chr 6:49,021,044...49,089,855
JBrowse link
G Tuba1a tubulin, alpha 1A multiple interactions ISO Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TUBA1A protein] CTD PMID:23562983 NCBI chr 7:140,637,287...140,640,953
Ensembl chr 7:140,637,287...140,640,953
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Minocycline results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vegfc vascular endothelial growth factor C multiple interactions ISO Minocycline inhibits the reaction [Oxygen deficiency results in increased expression of VEGFC mRNA] CTD PMID:24292262 NCBI chr16:40,440,371...40,555,178
Ensembl chr16:40,440,207...40,555,576
JBrowse link
G Vegfd vascular endothelial growth factor D multiple interactions ISO Minocycline inhibits the reaction [Oxygen deficiency results in increased expression of VEGFD mRNA] CTD PMID:24292262 NCBI chr  X:31,816,480...31,852,239
Ensembl chr  X:31,816,436...31,851,715
JBrowse link
G Vhl von Hippel-Lindau tumor suppressor multiple interactions ISO [[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] inhibits the reaction [Oxygen deficiency results in increased stability of HIF1A protein]; [[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] results in increased degradation of HIF1A protein; Minocycline promotes the reaction [HIF1A protein binds to VHL protein] CTD PMID:24292262 NCBI chr 4:145,580,869...145,587,835
Ensembl chr 4:145,580,799...145,587,845
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions EXP Minocycline inhibits the reaction [Paraquat results in increased expression of XBP1 protein] CTD PMID:22245251 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
G Xiap X-linked inhibitor of apoptosis increases expression
multiple interactions
EXP
ISO
Minocycline results in increased expression of XIAP protein
[Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of XIAP mRNA; [Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of XIAP protein
CTD PMID:14998631, PMID:20606027 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
oxytetracycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity ISO Oxytetracycline results in decreased activity of CAT protein CTD PMID:29248593 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Oxytetracycline results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO Oxytetracycline results in decreased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Oxytetracycline results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Oxytetracycline results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO Oxytetracycline results in decreased activity of DIO1 protein CTD PMID:29228274 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Oxytetracycline results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Oxytetracycline inhibits the reaction [SLC22A6 protein results in increased uptake of Anions] CTD PMID:11855680 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO Oxytetracycline inhibits the reaction [SLC22A7 protein results in increased uptake of Anions] CTD PMID:11855680 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Oxytetracycline results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
tetracycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadac arylacetamide deacetylase decreases expression ISO Tetracycline results in decreased expression of AADAC mRNA CTD PMID:24489787 NCBI chr 2:150,146,234...150,157,480
Ensembl chr 2:150,146,234...150,157,480
JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO Tetracycline results in increased expression of ABCA1 mRNA CTD PMID:16917069 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abca8 ATP binding cassette subfamily A member 8 increases expression ISO Tetracycline results in increased expression of ABCA8B mRNA CTD PMID:16917069 NCBI chr10:98,236,919...98,308,288
Ensembl chr10:98,237,141...98,294,522
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression EXP Tetracycline results in decreased expression of ABCB11 mRNA CTD PMID:17522070, PMID:19224547, PMID:27765674 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression EXP Tetracycline results in increased expression of ABCB1 mRNA CTD PMID:17522070, PMID:19224547 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression ISO
EXP
Tetracycline results in decreased expression of ABCB4 mRNA CTD PMID:24489787, PMID:27765674 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression EXP Tetracycline results in decreased expression of ABCC2 mRNA CTD PMID:27765674 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Tetracycline results in increased expression of ABCC3 mRNA CTD PMID:17522070, PMID:27765674 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases transport
increases expression
ISO
EXP
ABCC4 protein results in increased transport of Tetracycline
Tetracycline results in increased expression of ABCC4 mRNA
CTD PMID:17939016, PMID:27765674 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Abcd2 ATP binding cassette subfamily D member 2 decreases expression ISO Tetracycline results in decreased expression of ABCD2 mRNA CTD PMID:24489787 NCBI chr 7:132,294,564...132,343,169
Ensembl chr 7:132,294,562...132,343,169
JBrowse link
G Abcd3 ATP binding cassette subfamily D member 3 increases expression
decreases expression
ISO Tetracycline results in increased expression of ABCD3 mRNA
Tetracycline results in decreased expression of ABCD3 mRNA
CTD PMID:16917069, PMID:24489787 NCBI chr 2:225,335,708...225,389,120
Ensembl chr 2:225,335,718...225,389,120
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 decreases expression ISO Tetracycline results in decreased expression of ABCG2 mRNA CTD PMID:24489787 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 decreases expression ISO
EXP
Tetracycline results in decreased expression of ABCG5 mRNA CTD PMID:24489787, PMID:27765674 NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 decreases expression ISO Tetracycline results in decreased expression of ABCG8 mRNA CTD PMID:24489787 NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708
JBrowse link
G Acaca acetyl-CoA carboxylase alpha decreases expression ISO Tetracycline results in decreased expression of ACACA mRNA CTD PMID:24489787 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain multiple interactions
decreases expression
ISO bicyclol inhibits the reaction [Tetracycline results in decreased expression of ACADL mRNA] CTD PMID:19427351 NCBI chr 9:73,833,368...73,871,857
Ensembl chr 9:73,833,388...73,871,888
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain decreases expression EXP Tetracycline results in decreased expression of ACADM mRNA CTD PMID:17522070 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589
JBrowse link
G Acadsb acyl-CoA dehydrogenase, short/branched chain increases expression ISO Tetracycline results in increased expression of ACADSB mRNA CTD PMID:16917069 NCBI chr 1:201,981,362...202,022,771
Ensembl chr 1:201,981,357...202,021,008
JBrowse link
G Acadvl acyl-CoA dehydrogenase, very long chain decreases expression ISO Tetracycline results in decreased expression of ACADVL mRNA CTD PMID:24489787 NCBI chr10:56,619,321...56,624,468
Ensembl chr10:56,619,303...56,624,526
JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 decreases expression ISO Tetracycline results in decreased expression of ACAT1 mRNA CTD PMID:24489787 NCBI chr 8:58,166,990...58,195,884
Ensembl chr 8:58,166,990...58,195,884
JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 increases expression
decreases expression
ISO Tetracycline results in increased expression of ACAT2 mRNA
Tetracycline results in decreased expression of ACAT2 mRNA
CTD PMID:16917069, PMID:24489787 NCBI chr 1:47,972,399...47,992,654
Ensembl chr 1:47,972,399...47,992,653
JBrowse link
G Acbd5 acyl-CoA binding domain containing 5 increases expression ISO Tetracycline results in increased expression of ACBD5 mRNA CTD PMID:16917069 NCBI chr17:89,882,465...89,923,982
Ensembl chr17:89,883,615...89,923,423
JBrowse link
G Acly ATP citrate lyase decreases expression EXP Tetracycline results in decreased expression of ACLY mRNA CTD PMID:17522070 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression
decreases expression
ISO Tetracycline results in increased expression of ACOX1 mRNA
Tetracycline results in decreased expression of ACOX1 mRNA
CTD PMID:16917069, PMID:24489787 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Acox2 acyl-CoA oxidase 2 decreases expression EXP
ISO
Tetracycline results in decreased expression of ACOX2 mRNA CTD PMID:19224547, PMID:24489787 NCBI chr15:18,449,304...18,481,472
Ensembl chr15:18,451,144...18,481,470
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases expression
decreases expression
ISO
EXP
Tetracycline results in increased expression of ACSL1 mRNA
Tetracycline results in decreased expression of ACSL1 mRNA
CTD PMID:16917069, PMID:17522070, PMID:24489787 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Acsm1 acyl-CoA synthetase medium-chain family member 1 decreases expression ISO Tetracycline results in decreased expression of ACSM1 mRNA CTD PMID:24489787 NCBI chr 1:189,359,374...189,395,277
Ensembl chr 1:189,289,957...189,395,276
JBrowse link
G Acsm2 acyl-CoA synthetase medium-chain family member 2 increases expression ISO Tetracycline results in increased expression of ACSM2 mRNA CTD PMID:16917069 NCBI chr 1:189,289,957...189,329,007
Ensembl chr 1:189,289,957...189,395,276
JBrowse link
G Acsm3 acyl-CoA synthetase medium-chain family member 3 decreases expression ISO Tetracycline results in decreased expression of ACSM3 mRNA CTD PMID:24489787 NCBI chr 1:189,514,504...189,541,233
Ensembl chr 1:189,514,553...189,541,224
JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 decreases expression ISO Tetracycline results in decreased expression of ACSS2 mRNA CTD PMID:24489787 NCBI chr 3:151,032,925...151,075,856
Ensembl chr 3:151,032,952...151,075,856
JBrowse link
G Adipor2 adiponectin receptor 2 increases expression ISO Tetracycline results in increased expression of ADIPOR2 mRNA CTD PMID:16917069 NCBI chr 4:151,412,135...151,480,108
Ensembl chr 4:151,414,684...151,428,894
JBrowse link
G Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 increases expression ISO Tetracycline results in increased expression of AGPAT2 mRNA CTD PMID:16917069 NCBI chr 3:4,044,741...4,055,384
Ensembl chr 3:4,044,542...4,055,806
JBrowse link
G Agpat4 1-acylglycerol-3-phosphate O-acyltransferase 4 decreases expression ISO Tetracycline results in decreased expression of AGPAT4 mRNA CTD PMID:16917069 NCBI chr 1:48,716,094...48,826,292
Ensembl chr 1:48,719,633...48,825,364
JBrowse link
G Agt angiotensinogen decreases expression ISO Tetracycline results in decreased expression of AGT mRNA CTD PMID:24489787 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Ak3 adenylate kinase 3 decreases expression ISO Tetracycline results in decreased expression of AK3 mRNA CTD PMID:24489787 NCBI chr 1:247,144,486...247,169,690
Ensembl chr 1:247,144,491...247,169,693
JBrowse link
G Ak4 adenylate kinase 4 increases expression EXP Tetracycline results in increased expression of AK4 protein CTD PMID:16538043 NCBI chr 5:120,250,318...120,309,153
Ensembl chr 5:120,250,616...120,305,897
JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 increases expression ISO Tetracycline results in increased expression of AKR1D1 mRNA CTD PMID:16917069 NCBI chr 4:65,110,706...65,143,930
Ensembl chr 4:65,110,746...65,143,941
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 decreases expression ISO Tetracycline results in decreased expression of ALAS1 mRNA CTD PMID:24489787 NCBI chr 8:114,927,704...114,941,038
Ensembl chr 8:114,927,722...114,940,177
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression ISO Tetracycline results in decreased expression of ALDH1A1 mRNA CTD PMID:24489787 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 decreases expression EXP Tetracycline results in decreased expression of ALDH3A2 mRNA CTD PMID:17522070 NCBI chr10:47,525,486...47,546,535
Ensembl chr10:47,525,493...47,546,345
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression EXP Tetracycline results in increased expression of ALDOA mRNA CTD PMID:17522070 NCBI chr 1:198,228,387...198,233,988
Ensembl chr 1:198,228,387...198,233,588
JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein decreases expression ISO Tetracycline results in decreased expression of ALOX5AP mRNA CTD PMID:16917069 NCBI chr12:6,854,930...6,879,112
Ensembl chr12:6,854,920...6,879,154
JBrowse link
G Amacr alpha-methylacyl-CoA racemase decreases expression ISO Tetracycline results in decreased expression of AMACR mRNA CTD PMID:24489787 NCBI chr 2:60,949,276...60,961,342
Ensembl chr 2:60,949,256...60,961,326
JBrowse link
G Angptl3 angiopoietin-like 3 decreases expression ISO Tetracycline results in decreased expression of ANGPTL3 mRNA CTD PMID:24489787 NCBI chr 5:117,698,590...117,706,729
Ensembl chr 5:117,698,764...117,705,808
JBrowse link
G Aoah acyloxyacyl hydrolase increases expression ISO Tetracycline results in increased expression of AOAH mRNA CTD PMID:16917069 NCBI chr17:45,872,414...46,115,026
Ensembl chr17:45,872,414...46,115,004
JBrowse link
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression ISO Tetracycline results in decreased expression of AP1S1 mRNA CTD PMID:17175557 NCBI chr12:22,665,128...22,676,079
Ensembl chr12:22,665,112...22,676,075
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases expression EXP Tetracycline results in increased expression of APEX1 mRNA CTD PMID:17522070 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Apob apolipoprotein B decreases expression EXP Tetracycline results in decreased expression of APOB mRNA CTD PMID:19224547 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997
JBrowse link
G Apoc1 apolipoprotein C1 decreases expression ISO Tetracycline results in decreased expression of APOC1 mRNA CTD PMID:16917069 NCBI chr 1:80,606,638...80,609,921
Ensembl chr 1:80,606,638...80,609,921
JBrowse link
G Apoc2 apolipoprotein C2 decreases expression ISO Tetracycline results in decreased expression of APOC2 mRNA CTD PMID:16917069, PMID:24489787 NCBI chr 1:80,589,023...80,593,991
Ensembl chr 1:80,589,023...80,594,136
JBrowse link
G Apoc3 apolipoprotein C3 decreases expression ISO Tetracycline results in decreased expression of APOC3 mRNA CTD PMID:16917069 NCBI chr 8:50,529,318...50,531,498
Ensembl chr 8:50,529,318...50,531,498
JBrowse link
G Apof apolipoprotein F decreases expression ISO Tetracycline results in decreased expression of APOF mRNA CTD PMID:24489787 NCBI chr 7:2,689,501...2,690,938
Ensembl chr 7:2,689,501...2,690,936
JBrowse link
G Ar androgen receptor decreases expression ISO Tetracycline results in decreased expression of AR mRNA CTD PMID:16917069 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator increases expression ISO Tetracycline results in increased expression of ARNT mRNA CTD PMID:16917069 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Arsa arylsulfatase A decreases expression ISO Tetracycline results in decreased expression of ARSA mRNA CTD PMID:16917069 NCBI chr 7:130,446,644...130,452,632
Ensembl chr 7:130,446,668...130,451,283
JBrowse link
G Asgr2 asialoglycoprotein receptor 2 decreases expression ISO Tetracycline results in decreased expression of ASGR2 mRNA CTD PMID:24489787 NCBI chr10:56,710,446...56,723,608
Ensembl chr10:56,710,464...56,723,611
JBrowse link
G Asl argininosuccinate lyase increases expression EXP Tetracycline results in increased expression of ASL mRNA CTD PMID:17522070 NCBI chr12:30,160,922...30,178,348
Ensembl chr12:30,165,694...30,178,341
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Tetracycline results in increased expression of ASNS mRNA CTD PMID:17175557 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Atp11a ATPase phospholipid transporting 11A decreases expression ISO Tetracycline results in decreased expression of ATP11A mRNA CTD PMID:16917069 NCBI chr16:81,990,340...82,100,222
Ensembl chr16:81,990,340...82,100,222
JBrowse link
G Auh AU RNA binding methylglutaconyl-CoA hydratase increases expression ISO Tetracycline results in increased expression of AUH mRNA CTD PMID:16917069 NCBI chr17:12,310,178...12,405,224
Ensembl chr17:12,310,214...12,405,205
JBrowse link
G Bbox1 gamma-butyrobetaine hydroxylase 1 decreases expression ISO Tetracycline results in decreased expression of BBOX1 mRNA CTD PMID:24489787 NCBI chr 3:101,425,684...101,474,848
Ensembl chr 3:101,427,055...101,474,890
JBrowse link
G Bckdha branched chain keto acid dehydrogenase E1 subunit alpha increases expression EXP Tetracycline results in increased expression of BCKDHA protein CTD PMID:16538043 NCBI chr 1:82,423,291...82,452,094
Ensembl chr 1:82,423,277...82,452,281
JBrowse link
G Bdh1 3-hydroxybutyrate dehydrogenase 1 decreases expression ISO Tetracycline results in decreased expression of BDH1 mRNA CTD PMID:24489787 NCBI chr11:72,577,547...72,619,435
Ensembl chr11:72,578,533...72,614,176
JBrowse link
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin decreases expression ISO Tetracycline results in decreased expression of BSCL2 mRNA CTD PMID:24489787 NCBI chr 1:225,035,956...225,046,137
Ensembl chr 1:225,037,737...225,046,040
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression EXP Tetracycline results in increased expression of BTG2 mRNA CTD PMID:17522070 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
JBrowse link
G Ca3 carbonic anhydrase 3 increases expression EXP Tetracycline results in increased expression of CAR3 protein CTD PMID:16538043 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410
JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 increases expression ISO Tetracycline results in increased expression of CACNA2D1 mRNA CTD PMID:16917069 NCBI chr 4:15,706,974...16,130,848
Ensembl chr 4:15,710,417...16,130,848
JBrowse link
G Calu calumenin increases expression EXP Tetracycline results in increased expression of CALU mRNA CTD PMID:17522070 NCBI chr 4:56,625,611...56,653,112
Ensembl chr 4:56,625,561...56,653,111
JBrowse link
G Casp3 caspase 3 decreases expression ISO Tetracycline results in decreased expression of CASP3 mRNA CTD PMID:24489787 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase increases expression
decreases expression
ISO
EXP
Tetracycline results in increased expression of CAT mRNA
Tetracycline results in decreased expression of CAT mRNA
CTD PMID:16917069, PMID:17522070 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cbfa2t2 CBFA2/RUNX1 partner transcriptional co-repressor 2 increases expression ISO Tetracycline results in increased expression of CBFA2T2 mRNA CTD PMID:16917069 NCBI chr 3:149,935,731...150,041,545
Ensembl chr 3:149,935,731...150,038,257
JBrowse link
G Cbs cystathionine beta synthase decreases expression ISO Tetracycline results in decreased expression of CBS mRNA CTD PMID:24489787 NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression ISO Tetracycline results in increased expression of CCN2 mRNA CTD PMID:16917069 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccnb3 cyclin B3 increases expression ISO Tetracycline results in increased expression of CCNB3 mRNA CTD PMID:16917069 NCBI chr  X:16,300,752...16,402,206
Ensembl chr  X:16,337,102...16,402,202
JBrowse link
G Ccnd1 cyclin D1 decreases expression EXP Tetracycline results in decreased expression of CCND1 mRNA CTD PMID:19224547 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccng1 cyclin G1 increases expression EXP Tetracycline results in increased expression of CCNG1 mRNA CTD PMID:17522070 NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325
JBrowse link
G Cd36 CD36 molecule multiple interactions
increases expression
ISO [Tetracycline results in increased expression of CD36 protein] which results in increased uptake of Fatty Acids
Tetracycline results in increased expression of CD36 mRNA; Tetracycline results in increased expression of CD36 protein
CTD PMID:25745068 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cers2 ceramide synthase 2 increases expression ISO Tetracycline results in increased expression of CERS2 mRNA CTD PMID:16917069 NCBI chr 2:196,487,656...196,495,930
Ensembl chr 2:196,487,656...196,496,986
JBrowse link
G Cers5 ceramide synthase 5 increases expression ISO Tetracycline results in increased expression of CERS5 mRNA CTD PMID:16917069 NCBI chr 7:141,386,391...141,424,375
Ensembl chr 7:141,386,391...141,424,343
JBrowse link
G Chka choline kinase alpha increases expression ISO Tetracycline results in increased expression of CHKA mRNA CTD PMID:16917069 NCBI chr 1:219,076,618...219,126,221
Ensembl chr 1:219,077,771...219,126,220
JBrowse link
G Cideb cell death-inducing DFFA-like effector b decreases expression ISO Tetracycline results in decreased expression of CIDEB mRNA CTD PMID:24489787 NCBI chr15:34,439,844...34,444,244
Ensembl chr15:34,439,876...34,444,244
JBrowse link
G Cldn10 claudin 10 decreases expression ISO Tetracycline results in decreased expression of CLDN10 mRNA CTD PMID:28882639 NCBI chr15:104,026,590...104,115,748
Ensembl chr15:104,026,601...104,115,748
JBrowse link
G Cldn11 claudin 11 decreases expression ISO Tetracycline results in decreased expression of CLDN11 mRNA CTD PMID:28882639 NCBI chr 2:115,823,541...115,836,846
Ensembl chr 2:115,823,538...115,836,846
JBrowse link
G Cldn15 claudin 15 decreases expression ISO Tetracycline results in decreased expression of CLDN15 mRNA CTD PMID:28882639 NCBI chr12:22,738,198...22,750,392
Ensembl chr12:22,738,195...22,748,860
JBrowse link
G Cldn2 claudin 2 decreases expression ISO Tetracycline results in decreased expression of CLDN2 mRNA CTD PMID:28882639 NCBI chr  X:111,122,552...111,133,188
Ensembl chr  X:111,122,552...111,137,769
JBrowse link
G Cldn6 claudin 6 decreases expression ISO Tetracycline results in decreased expression of CLDN6 mRNA CTD PMID:28882639 NCBI chr10:12,999,256...13,002,860
Ensembl chr10:13,000,090...13,002,862
JBrowse link
G Cldn8 claudin 8 decreases expression ISO Tetracycline results in decreased expression of CLDN8 mRNA CTD PMID:28882639 NCBI chr11:28,525,641...28,527,890
Ensembl chr11:28,525,643...28,527,890
JBrowse link
G Clu clusterin increases expression EXP Tetracycline results in increased expression of CLU mRNA CTD PMID:17522070 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cox19 cytochrome c oxidase assembly factor COX19 decreases expression ISO Tetracycline results in decreased expression of COX19 mRNA CTD PMID:24489787 NCBI chr12:17,395,624...17,405,103
Ensembl chr12:17,395,624...17,405,103
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression EXP
ISO
Tetracycline results in decreased expression of CPT1A mRNA CTD PMID:19224547, PMID:24489787 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Crat carnitine O-acetyltransferase decreases expression ISO Tetracycline results in decreased expression of CRAT mRNA CTD PMID:16917069 NCBI chr 3:8,967,984...8,981,959
Ensembl chr 3:8,968,417...8,981,362
JBrowse link
G Crot carnitine O-octanoyltransferase increases expression
decreases expression
ISO Tetracycline results in increased expression of CROT mRNA
Tetracycline results in decreased expression of CROT mRNA
CTD PMID:16917069, PMID:24489787 NCBI chr 4:22,079,837...22,116,265
Ensembl chr 4:22,081,604...22,116,265
JBrowse link
G Cryab crystallin, alpha B decreases expression ISO Tetracycline results in decreased expression of CRYAB mRNA CTD PMID:24489787 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
JBrowse link
G Csf1 colony stimulating factor 1 increases expression ISO Tetracycline results in increased expression of CSF1 mRNA CTD PMID:16917069 NCBI chr 2:210,522,370...210,550,546
Ensembl chr 2:210,522,375...210,550,560
JBrowse link
G Ctsl cathepsin L increases expression EXP Tetracycline results in increased expression of CTSL mRNA CTD PMID:17522070 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO Tetracycline results in decreased expression of CXCL12 mRNA CTD PMID:24489787 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cyb5a cytochrome b5 type A decreases expression ISO Tetracycline results in decreased expression of CYB5A mRNA CTD PMID:16917069 NCBI chr18:81,694,818...81,726,821
Ensembl chr18:81,694,808...81,726,821
JBrowse link
G Cyb5b cytochrome b5 type B increases expression ISO Tetracycline results in increased expression of CYB5B mRNA CTD PMID:16917069 NCBI chr19:39,357,814...39,391,680
Ensembl chr19:39,357,791...39,393,189
JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 decreases expression EXP Tetracycline results in decreased expression of CYB5R3 mRNA CTD PMID:17522070 NCBI chr 7:124,024,003...124,041,564
Ensembl chr 7:124,023,995...124,041,594
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO Tetracycline results in decreased expression of CYP17A1 mRNA CTD PMID:16917069 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression EXP Tetracycline results in decreased expression of CYP1A1 mRNA CTD PMID:19224547 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 increases expression ISO Tetracycline results in increased expression of CYP21A1 mRNA CTD PMID:16917069 NCBI chr20:4,486,213...4,489,358
Ensembl chr20:4,486,219...4,489,550
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 decreases expression ISO Tetracycline results in decreased expression of CYP26A1 mRNA CTD PMID:16917069 NCBI chr 1:256,382,861...256,386,729
Ensembl chr 1:256,382,791...256,386,729
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression ISO Tetracycline results in decreased expression of CYP27A1 mRNA CTD PMID:24489787 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 decreases expression ISO Tetracycline results in decreased expression of CYP2A5 mRNA CTD PMID:16917069 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases expression ISO Tetracycline results in increased expression of CYP2C38 mRNA CTD PMID:16917069 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 decreases expression EXP Tetracycline results in decreased expression of CYP2D3 mRNA CTD PMID:17522070 NCBI chr 7:123,634,400...123,638,757
Ensembl chr 7:123,625,590...123,638,765
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases expression
ISO bicyclol inhibits the reaction [Tetracycline results in decreased expression of CYP2E1 mRNA] CTD PMID:19427351 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 increases expression ISO Tetracycline results in increased expression of CYP2J9 mRNA CTD PMID:16917069 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases expression EXP Tetracycline results in decreased expression of CYP3A4 mRNA CTD PMID:19224547 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 decreases expression ISO Tetracycline results in decreased expression of CYP46A1 mRNA CTD PMID:16917069 NCBI chr 6:132,242,328...132,273,788
Ensembl chr 6:132,242,328...132,273,787
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression
multiple interactions
decreases expression
EXP
ISO
Tetracycline results in increased expression of CYP4A1 mRNA
bicyclol inhibits the reaction [Tetracycline results in decreased expression of CYP4A12B mRNA]
Tetracycline results in decreased expression of CYP4A22 mRNA
CTD PMID:12883083, PMID:19224547, PMID:19427351 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154
JBrowse link
G Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 increases expression ISO Tetracycline results in increased expression of CYP4F14 mRNA CTD PMID:16917069 NCBI chr 7:15,179,472...15,191,113
Ensembl chr 7:15,179,467...15,190,796
JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 increases expression ISO Tetracycline results in increased expression of CYP4F18 mRNA CTD PMID:16917069 NCBI chr16:19,501,680...19,528,935
Ensembl chr16:19,410,810...19,528,999
JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression ISO Tetracycline results in increased expression of CYP51 mRNA CTD PMID:16917069 NCBI chr 4:27,175,564...27,194,018
Ensembl chr 4:27,175,243...27,194,018
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression
decreases expression
ISO
EXP
Tetracycline results in increased expression of CYP7A1 mRNA
Tetracycline results in decreased expression of CYP7A1 mRNA
CTD PMID:16917069, PMID:19224547 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases expression ISO Tetracycline results in decreased expression of CYP7B1 mRNA CTD PMID:24489787 NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 increases expression
decreases expression
ISO Tetracycline results in increased expression of CYP8B1 mRNA
Tetracycline results in decreased expression of CYP8B1 mRNA
CTD PMID:16917069, PMID:24489787 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388
JBrowse link
G Dbi diazepam binding inhibitor, acyl-CoA binding protein decreases expression ISO Tetracycline results in decreased expression of DBI mRNA CTD PMID:16917069 NCBI chr13:36,147,667...36,156,076
Ensembl chr13:36,117,119...36,174,908
JBrowse link
G Ddc dopa decarboxylase decreases expression ISO Tetracycline results in decreased expression of DDC mRNA CTD PMID:24489787 NCBI chr14:91,905,919...91,996,816
Ensembl chr14:91,905,919...91,996,774
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP Tetracycline results in increased expression of DDIT3 mRNA CTD PMID:12883083, PMID:17522070 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Depp1 DEPP1, autophagy regulator increases expression ISO Tetracycline results in increased expression of DEPP1 mRNA CTD PMID:17175557 NCBI chr 4:148,780,330...148,784,566
Ensembl chr 4:148,782,479...148,784,562
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 increases expression
multiple interactions
ISO Tetracycline results in increased expression of DGAT2 protein
Tetracycline results in increased expression of DGAT2 mRNA; Tetracycline results in increased expression of DGAT2 protein
Tetracycline promotes the reaction [DGAT2 protein results in increased chemical synthesis of Triglycerides]
CTD PMID:25745068 NCBI chr 1:164,113,459...164,143,818
Ensembl chr 1:164,113,459...164,143,818
JBrowse link
G Dgka diacylglycerol kinase, alpha decreases expression ISO Tetracycline results in decreased expression of DGKA mRNA CTD PMID:16917069 NCBI chr 7:3,143,826...3,170,764
Ensembl chr 7:3,143,827...3,170,146
JBrowse link
G Dhx29 DExH-box helicase 29 increases expression ISO Tetracycline results in increased expression of DHX29 mRNA CTD PMID:16917069 NCBI chr 2:44,787,066...44,837,834
Ensembl chr 2:44,787,002...44,837,831
JBrowse link
G Dnajb8 DnaJ heat shock protein family (Hsp40) member B8 increases expression ISO Tetracycline results in increased expression of DNAJB8 mRNA CTD PMID:16917069 NCBI chr 4:120,156,640...120,159,708
Ensembl chr 4:120,156,659...120,159,265
JBrowse link
G Dpm1 dolichyl-phosphate mannosyltransferase subunit 1, catalytic decreases expression ISO Tetracycline results in decreased expression of DPM1 mRNA CTD PMID:16917069 NCBI chr 3:164,966,637...164,986,180
Ensembl chr 3:164,966,637...164,986,180
JBrowse link
G Eci1 enoyl-CoA delta isomerase 1 decreases expression ISO Tetracycline results in decreased expression of ECI1 mRNA CTD PMID:16917069 NCBI chr10:13,797,573...13,810,918
Ensembl chr10:13,797,562...13,810,913
JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO Tetracycline results in decreased expression of EGFR mRNA CTD PMID:24489787 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase decreases expression ISO Tetracycline results in decreased expression of EHHADH mRNA CTD PMID:27089845 NCBI chr11:82,945,104...82,978,364
Ensembl chr11:82,945,104...82,978,364
JBrowse link
G Elovl2 ELOVL fatty acid elongase 2 decreases expression ISO Tetracycline results in decreased expression of ELOVL2 mRNA CTD PMID:24489787 NCBI chr17:21,382,461...21,422,413
Ensembl chr17:21,382,455...21,422,407
JBrowse link
G Elovl3 ELOVL fatty acid elongase 3 increases expression ISO Tetracycline results in increased expression of ELOVL3 mRNA CTD PMID:16917069 NCBI chr 1:265,883,353...265,887,181
Ensembl chr 1:265,883,355...265,887,226
JBrowse link
G Elovl5 ELOVL fatty acid elongase 5 increases expression ISO Tetracycline results in increased expression of ELOVL5 mRNA CTD PMID:16917069 NCBI chr 8:85,220,941...85,287,449
Ensembl chr 8:85,259,982...85,285,983
JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 decreases expression
increases expression
EXP
ISO
Tetracycline results in decreased expression of ELOVL6 mRNA
Tetracycline results in increased expression of ELOVL6 mRNA
CTD PMID:16917069, PMID:19224547 NCBI chr 2:234,187,490...234,296,124
Ensembl chr 2:234,189,105...234,296,145
Ensembl chr 2:234,189,105...234,296,145
JBrowse link
G Endog endonuclease G decreases expression ISO Tetracycline results in decreased expression of ENDOG mRNA CTD PMID:24489787 NCBI chr 3:8,741,833...8,744,414
Ensembl chr 3:8,741,766...8,744,592
JBrowse link
G Ephx1 epoxide hydrolase 1 decreases expression ISO Tetracycline results in decreased expression of EPHX1 mRNA CTD PMID:24489787 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression ISO Tetracycline results in decreased expression of EPHX2 mRNA CTD PMID:24489787 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
JBrowse link
G Ergic2 ERGIC and golgi 2 increases expression ISO Tetracycline results in increased expression of ERGIC2 mRNA CTD PMID:16917069 NCBI chr 4:182,569,086...182,600,258
Ensembl chr 4:182,569,089...182,600,258
JBrowse link
G Etfdh electron transfer flavoprotein dehydrogenase decreases expression ISO Tetracycline results in decreased expression of ETFDH mRNA CTD PMID:24489787 NCBI chr 2:178,367,547...178,389,641
Ensembl chr 2:178,367,549...178,389,608
JBrowse link
G Exosc10 exosome component 10 increases expression ISO Tetracycline results in increased expression of EXOSC10 mRNA CTD PMID:16917069 NCBI chr 5:165,374,964...165,398,195
Ensembl chr 5:165,374,951...165,398,217
JBrowse link
G Exosc9 exosome component 9 increases expression ISO Tetracycline results in increased expression of EXOSC9 mRNA CTD PMID:16917069 NCBI chr 2:123,264,679...123,275,623
Ensembl chr 2:123,264,694...123,294,880
JBrowse link
G F10 coagulation factor X decreases expression ISO Tetracycline results in decreased expression of F10 mRNA CTD PMID:24489787 NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716
JBrowse link
G Faah fatty acid amide hydrolase increases expression ISO Tetracycline results in increased expression of FAAH mRNA CTD PMID:16917069 NCBI chr 5:134,852,899...134,872,095
Ensembl chr 5:134,852,875...134,871,775
JBrowse link
G Faahl fatty-acid amide hydrolase-like increases expression ISO Tetracycline results in increased expression of FAAH mRNA CTD PMID:16917069 NCBI chr 5:134,330,204...134,349,400
Ensembl chr 5:134,331,929...134,348,995
JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression EXP
ISO
Tetracycline results in decreased expression of FABP1 mRNA CTD PMID:16917069, PMID:17522070, PMID:19224547, PMID:24489787 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression ISO Tetracycline results in decreased expression of FABP4 mRNA CTD PMID:16917069 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fabp7 fatty acid binding protein 7 decreases expression ISO Tetracycline results in decreased expression of FABP7 mRNA CTD PMID:16917069 NCBI chr20:40,769,624...40,773,156
Ensembl chr20:40,769,586...40,773,349
JBrowse link
G Fads1 fatty acid desaturase 1 decreases expression EXP Tetracycline results in decreased expression of FADS1 mRNA CTD PMID:17522070 NCBI chr 1:226,234,034...226,249,118
Ensembl chr 1:226,234,074...226,249,138
JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO Tetracycline results in decreased expression of FAS mRNA CTD PMID:24489787 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fasn fatty acid synthase decreases expression EXP Tetracycline results in decreased expression of FASN mRNA CTD PMID:17522070, PMID:19224547 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 decreases expression ISO Tetracycline results in decreased expression of FDFT1 mRNA CTD PMID:24489787 NCBI chr15:46,339,248...46,367,302
Ensembl chr15:46,339,249...46,367,302
JBrowse link
G Fdx1 ferredoxin 1 decreases expression ISO Tetracycline results in decreased expression of FDX1 mRNA CTD PMID:16917069 NCBI chr 8:56,373,729...56,393,199
Ensembl chr 8:56,373,723...56,393,233
JBrowse link
G Fezf2 Fez family zinc finger 2 increases expression ISO Tetracycline results in increased expression of FEZF2 mRNA CTD PMID:16917069 NCBI chr15:12,825,333...12,831,496
Ensembl chr15:12,827,707...12,831,496
JBrowse link
G Fga fibrinogen alpha chain increases expression EXP Tetracycline results in increased expression of FGA mRNA CTD PMID:17522070 NCBI chr 2:181,997,562...182,013,726
Ensembl chr 2:182,006,242...182,013,763
JBrowse link
G Fgb fibrinogen beta chain increases expression EXP Tetracycline results in increased expression of FGB mRNA CTD PMID:17522070 NCBI chr 2:182,028,044...182,035,026
Ensembl chr 2:182,027,115...182,038,178
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 decreases expression EXP Tetracycline results in decreased expression of FMO1 mRNA CTD PMID:17522070 NCBI chr13:80,712,885...80,745,095
Ensembl chr13:80,712,882...80,745,347
JBrowse link
G Foxa1 forkhead box A1 decreases expression EXP Tetracycline results in decreased expression of FOXA1 mRNA CTD PMID:24469900 NCBI chr 6:78,516,579...78,549,669
Ensembl chr 6:78,545,804...78,549,669
JBrowse link
G Fxyd7 FXYD domain-containing ion transport regulator 7 increases expression ISO Tetracycline results in increased expression of FXYD7 mRNA CTD PMID:16917069 NCBI chr 1:89,474,601...89,484,069
Ensembl chr 1:89,474,601...89,483,988
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO Tetracycline results in decreased expression of G6PC mRNA CTD PMID:24489787 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Tetracycline results in increased expression of GADD45A mRNA CTD PMID:17522070, PMID:19224547 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gata2 GATA binding protein 2 increases expression ISO Tetracycline results in increased expression of GATA2 mRNA CTD PMID:16917069 NCBI chr 4:120,129,028...120,142,490
Ensembl chr 4:120,133,713...120,142,488
JBrowse link
G Gba2 glucosylceramidase beta 2 increases expression ISO Tetracycline results in increased expression of GBA2 mRNA CTD PMID:16917069 NCBI chr 5:59,068,081...59,079,719
Ensembl chr 5:59,068,081...59,079,719
JBrowse link
G Gde1 glycerophosphodiester phosphodiesterase 1 decreases expression ISO Tetracycline results in decreased expression of GDE1 mRNA CTD PMID:16917069 NCBI chr 1:188,367,550...188,407,125
Ensembl chr 1:188,394,814...188,407,132
JBrowse link
G Gdpd1 glycerophosphodiester phosphodiesterase domain containing 1 decreases expression ISO Tetracycline results in decreased expression of GDPD1 mRNA CTD PMID:16917069 NCBI chr10:74,334,972...74,376,332
Ensembl chr10:74,334,975...74,376,270
JBrowse link
G Gga1 golgi associated, gamma adaptin ear containing, ARF binding protein 1 increases expression ISO Tetracycline results in increased expression of GGA1 mRNA CTD PMID:16917069 NCBI chr 7:120,102,596...120,119,738
Ensembl chr 7:120,106,901...120,119,737
JBrowse link
G Gja8 gap junction protein, alpha 8 decreases expression ISO Tetracycline results in decreased expression of GJA8 mRNA CTD PMID:28882639 NCBI chr 2:199,050,854...199,052,470
Ensembl chr 2:199,050,854...199,052,470
JBrowse link
G Gjd2 gap junction protein, delta 2 decreases expression ISO Tetracycline results in decreased expression of GJD2 mRNA CTD PMID:28882639 NCBI chr 3:105,467,480...105,470,475
Ensembl chr 3:105,467,480...105,470,475
JBrowse link
G Glud1 glutamate dehydrogenase 1 increases expression EXP Tetracycline results in increased expression of GLUD1 protein CTD PMID:16538043 NCBI chr16:10,661,486...10,695,557
Ensembl chr16:10,662,021...10,695,557
JBrowse link
G Glyat glycine-N-acyltransferase decreases expression ISO Tetracycline results in decreased expression of GLYAT mRNA CTD PMID:24489787 NCBI chr 1:229,060,125...229,081,113
Ensembl chr 1:229,063,714...229,080,410
JBrowse link
G Gmpr2 guanosine monophosphate reductase 2 increases expression ISO Tetracycline results in increased expression of GMPR2 mRNA CTD PMID:16917069 NCBI chr15:34,352,857...34,362,074
Ensembl chr15:34,352,914...34,362,032
JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 decreases expression ISO Tetracycline results in decreased expression of GPD1 mRNA CTD PMID:24489787 NCBI chr 7:141,368,928...141,377,931
Ensembl chr 7:141,370,491...141,377,928
JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 increases expression ISO Tetracycline results in increased expression of GPD2 mRNA CTD PMID:16917069 NCBI chr 3:43,223,892...43,359,069
Ensembl chr 3:43,255,567...43,359,074
JBrowse link
G Gpr151 G protein-coupled receptor 151 increases expression ISO Tetracycline results in increased expression of GPR151 mRNA CTD PMID:16917069 NCBI chr18:36,892,403...36,893,797
Ensembl chr18:36,892,403...36,893,797
JBrowse link
G Gpt2 glutamic--pyruvic transaminase 2 decreases expression ISO Tetracycline results in decreased expression of GPT2 mRNA CTD PMID:24489787 NCBI chr19:22,599,003...22,633,529
Ensembl chr19:22,590,881...22,632,071
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression EXP Tetracycline results in decreased expression of GPX1 mRNA CTD PMID:17522070 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gpx3 glutathione peroxidase 3 decreases expression ISO Tetracycline results in decreased expression of GPX3 mRNA CTD PMID:16917069 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422
JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression ISO Tetracycline results in decreased expression of GPX4 mRNA CTD PMID:16917069 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases expression EXP Tetracycline results in decreased expression of GSTA2 mRNA CTD PMID:19224547 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gstm3 glutathione S-transferase mu 3 decreases activity ISO Tetracycline results in decreased activity of GSTM3 protein CTD PMID:11807801 NCBI chr 2:210,685,204...210,688,273
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases activity
decreases expression
ISO
EXP
Tetracycline results in decreased activity of GSTM3 protein
Tetracycline results in decreased expression of GSTM3 mRNA
CTD PMID:11807801, PMID:17522070 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
decreases activity
ISO Tetracycline inhibits the reaction [GSTP1 protein affects the metabolism of and results in decreased activity of Ethacrynic Acid]
Tetracycline results in decreased activity of GSTP1 protein
CTD PMID:11807801 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gys2 glycogen synthase 2 decreases expression EXP Tetracycline results in decreased expression of GYS2 mRNA CTD PMID:19224547 NCBI chr 4:176,638,632...176,679,805
Ensembl chr 4:176,638,629...176,679,815
JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase decreases expression ISO Tetracycline results in decreased expression of HADH mRNA CTD PMID:24489787 NCBI chr 2:236,353,445...236,395,067
Ensembl chr 2:236,353,445...236,395,067
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha increases expression
decreases expression
ISO Tetracycline results in increased expression of HADHA mRNA
Tetracycline results in decreased expression of HADHA mRNA
CTD PMID:16917069, PMID:24489787 NCBI chr 6:27,589,840...27,628,921
Ensembl chr 6:27,589,657...27,629,175
JBrowse link
G Hexb hexosaminidase subunit beta increases expression ISO Tetracycline results in increased expression of HEXB mRNA CTD PMID:16917069 NCBI chr 2:27,983,925...28,003,260
Ensembl chr 2:27,984,117...28,003,186
JBrowse link
G Hhex hematopoietically expressed homeobox decreases expression EXP Tetracycline results in decreased expression of HHEX mRNA CTD PMID:24469900 NCBI chr 1:256,101,994...256,107,581
Ensembl chr 1:256,101,903...256,107,649
JBrowse link
G Hibadh 3-hydroxyisobutyrate dehydrogenase decreases expression EXP Tetracycline results in decreased expression of HIBADH mRNA CTD PMID:17522070 NCBI chr 4:82,604,369...82,702,429
Ensembl chr 4:82,604,373...82,702,429
JBrowse link
G Hjv hemojuvelin BMP co-receptor decreases expression ISO Tetracycline results in decreased expression of HJV mRNA CTD PMID:24489787 NCBI chr 2:198,655,437...198,659,318
Ensembl chr 2:198,655,437...198,659,317
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression EXP Tetracycline results in decreased expression of HMGCR mRNA CTD PMID:19224547 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Tetracycline results in increased expression of HMGCS1 mRNA CTD PMID:16917069 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression ISO Tetracycline results in decreased expression of HMGCS2 mRNA CTD PMID:24489787 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Tetracycline results in increased expression of HMOX1 mRNA CTD PMID:19224547 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases expression EXP
ISO
Tetracycline results in decreased expression of HNF4A mRNA CTD PMID:24469900, PMID:24489787 NCBI chr 3:159,902,441...159,965,003
Ensembl chr 3:159,902,441...159,965,003
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase decreases expression ISO Tetracycline results in decreased expression of HPGD mRNA CTD PMID:24489787 NCBI chr16:37,457,134...37,495,758
Ensembl chr16:37,457,135...37,495,758
JBrowse link
G Hpn hepsin decreases expression EXP Tetracycline results in decreased expression of HPN mRNA CTD PMID:19224547 NCBI chr 1:89,534,112...89,549,575
Ensembl chr 1:89,534,106...89,543,967
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 increases expression ISO Tetracycline results in increased expression of HSD17B1 mRNA CTD PMID:16917069 NCBI chr10:88,987,558...88,989,758
Ensembl chr10:88,987,558...88,989,757
JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 increases expression ISO Tetracycline results in increased expression of HSD17B2 mRNA CTD PMID:16917069 NCBI chr19:50,246,404...50,317,892
Ensembl chr19:50,246,402...50,317,891
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 decreases expression ISO Tetracycline results in decreased expression of HSD17B4 mRNA CTD PMID:24489787 NCBI chr18:44,810,462...44,897,677
Ensembl chr18:44,810,388...44,897,640
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 increases expression ISO Tetracycline results in increased expression of HSD3B2 mRNA CTD PMID:16917069
G Hsd3b7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 increases expression ISO Tetracycline results in increased expression of HSD3B7 mRNA CTD PMID:16917069 NCBI chr 1:199,248,084...199,251,745
Ensembl chr 1:199,248,470...199,251,740
JBrowse link
G Hsf2 heat shock transcription factor 2 decreases expression ISO Tetracycline results in decreased expression of HSF2 mRNA CTD PMID:24489787 NCBI chr20:38,935,820...38,963,444
Ensembl chr20:38,935,820...38,963,309
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 increases expression ISO Tetracycline results in increased expression of HSP90B1 mRNA CTD PMID:16917069 NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression EXP Tetracycline results in increased expression of HSPA1A mRNA CTD PMID:17522070 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression EXP Tetracycline results in increased expression of HSPD1 protein CTD PMID:16538043 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression EXP Tetracycline results in increased expression of ICAM1 mRNA CTD PMID:17522070 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 decreases expression ISO Tetracycline results in decreased expression of IDH1 mRNA CTD PMID:24489787 NCBI chr 9:71,882,108...71,911,645
Ensembl chr 9:71,882,105...71,900,044
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression EXP
ISO
Tetracycline results in increased expression of IGFBP1 mRNA CTD PMID:17522070, PMID:27089845 NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 decreases expression ISO Tetracycline results in decreased expression of IGFBP2 mRNA CTD PMID:24489787 NCBI chr 9:80,118,029...80,144,804
Ensembl chr 9:80,118,029...80,144,789
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 decreases expression ISO Tetracycline results in decreased expression of IGFBP3 mRNA CTD PMID:24489787 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO Tetracycline analog inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Tetracycline inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Tetracycline inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]
Tetracycline results in decreased expression of IL1B mRNA
CTD PMID:17267227, PMID:24489787 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 decreases expression ISO Tetracycline results in decreased expression of IL6 mRNA CTD PMID:24489787 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Tetracycline results in increased expression of INHBE mRNA CTD PMID:17175557 NCBI chr 7:70,641,423...70,642,848
Ensembl chr 7:70,640,075...70,643,169
JBrowse link
G Inpp5f inositol polyphosphate-5-phosphatase F increases expression ISO Tetracycline results in increased expression of INPP5F mRNA CTD PMID:16917069 NCBI chr 1:200,037,749...200,116,524
Ensembl chr 1:200,037,749...200,116,524
JBrowse link
G Insig2 insulin induced gene 2 increases expression ISO Tetracycline results in increased expression of INSIG2 mRNA CTD PMID:16917069 NCBI chr13:37,264,818...37,292,718
Ensembl chr13:37,266,312...37,287,458
JBrowse link
G Isyna1 inositol-3-phosphate synthase 1 decreases expression ISO Tetracycline results in decreased expression of ISYNA1 mRNA CTD PMID:24489787 NCBI chr16:20,589,497...20,592,333
Ensembl chr16:20,589,481...20,592,449
JBrowse link
G Itga3 integrin subunit alpha 3 decreases expression ISO Tetracycline results in decreased expression of ITGA3 mRNA CTD PMID:28882639 NCBI chr10:82,855,841...82,887,755
Ensembl chr10:82,855,613...82,887,497
JBrowse link
G Itga5 integrin subunit alpha 5 increases expression ISO Tetracycline results in increased expression of ITGA5 mRNA CTD PMID:28882639 NCBI chr 7:144,970,444...144,993,652
Ensembl chr 7:144,970,444...144,993,652
JBrowse link
G Itgae integrin subunit alpha E increases expression ISO Tetracycline results in increased expression of ITGAE mRNA CTD PMID:16917069 NCBI chr10:59,652,324...59,711,885
Ensembl chr10:59,539,405...59,711,874
JBrowse link
G Itgal integrin subunit alpha L decreases expression ISO Tetracycline results in decreased expression of ITGAL mRNA CTD PMID:28882639 NCBI chr 1:198,744,053...198,781,745
Ensembl chr 1:198,744,050...198,781,750
JBrowse link
G Itgam integrin subunit alpha M decreases expression ISO Tetracycline results in decreased expression of ITGAM mRNA CTD PMID:28882639 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Jag1 jagged canonical Notch ligand 1 increases expression ISO Tetracycline results in increased expression of JAG1 mRNA CTD PMID:16917069 NCBI chr 3:130,079,361...130,114,781
Ensembl chr 3:130,079,361...130,114,770
JBrowse link
G Jak1 Janus kinase 1 increases expression ISO Tetracycline results in increased expression of JAK1 mRNA CTD PMID:16917069 NCBI chr 5:119,982,503...120,091,452
Ensembl chr 5:119,982,943...120,083,904
JBrowse link
G Kera keratocan increases expression ISO Tetracycline results in increased expression of KERA mRNA CTD PMID:16917069 NCBI chr 7:38,858,062...38,865,515
Ensembl chr 7:38,858,062...38,865,515
JBrowse link
G Krt18 keratin 18 increases expression EXP Tetracycline results in increased expression of KRT18 mRNA CTD PMID:17522070 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Krt8 keratin 8 increases expression EXP Tetracycline results in increased expression of KRT8 mRNA CTD PMID:17522070 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
JBrowse link
G Lbp lipopolysaccharide binding protein increases expression EXP Tetracycline results in increased expression of LBP mRNA CTD PMID:17522070 NCBI chr 3:154,786,232...154,812,910
Ensembl chr 3:154,786,215...154,813,464
JBrowse link
G Lcat lecithin cholesterol acyltransferase decreases expression ISO Tetracycline results in decreased expression of LCAT mRNA CTD PMID:24489787 NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813
JBrowse link
G Lgals3 galectin 3 increases expression EXP Tetracycline results in increased expression of LGALS3 mRNA CTD PMID:17522070 NCBI chr15:24,153,602...24,165,537
Ensembl chr15:24,141,651...24,165,537
JBrowse link
G Lipc lipase C, hepatic type decreases expression EXP Tetracycline results in decreased expression of LIPC mRNA CTD PMID:17522070 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248
JBrowse link
G LOC100365958 Rdh2 protein-like decreases expression ISO Tetracycline results in decreased expression of RDH16 mRNA CTD PMID:16917069 NCBI chr 7:71,065,077...71,074,128
Ensembl chr 7:70,980,422...71,072,689
JBrowse link
G LOC100909485 spindlin-2-like decreases expression EXP Tetracycline results in decreased expression of SPIN2B mRNA CTD PMID:17522070 NCBI chr  X:18,340,413...18,342,492
Ensembl chr  X:18,340,688...18,341,467
JBrowse link
G LOC102548682 histone H4-like increases expression ISO Tetracycline results in increased expression of H4C14 mRNA CTD PMID:16917069 NCBI chr17:43,616,218...43,673,659
Ensembl chr17:43,791,657...43,792,067
Ensembl chr17:43,791,657...43,792,067
Ensembl chr17:43,791,657...43,792,067
Ensembl chr 2:43,791,657...43,792,067
Ensembl chr17:43,791,657...43,792,067
Ensembl chr17:43,791,657...43,792,067
Ensembl chr 2:43,791,657...43,792,067
Ensembl chr 2:43,791,657...43,792,067
JBrowse link
G Lpl lipoprotein lipase increases expression EXP Tetracycline results in increased expression of LPL mRNA CTD PMID:17522070 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Lrig3 leucine-rich repeats and immunoglobulin-like domains 3 increases expression ISO Tetracycline results in increased expression of LRIG3 mRNA CTD PMID:16917069 NCBI chr 7:69,213,098...69,263,251
Ensembl chr 7:69,213,147...69,263,142
JBrowse link
G Lrp4 LDL receptor related protein 4 decreases expression ISO Tetracycline results in decreased expression of LRP4 mRNA CTD PMID:16917069 NCBI chr 3:80,362,643...80,416,684
Ensembl chr 3:80,362,858...80,416,679
JBrowse link
G Lrrc4b leucine rich repeat containing 4B increases expression ISO Tetracycline results in increased expression of LRRC4B mRNA CTD PMID:16917069 NCBI chr 1:100,434,418...100,468,914
Ensembl chr 1:100,447,998...100,468,868
JBrowse link
G Mal mal, T-cell differentiation protein increases expression ISO Tetracycline results in increased expression of MAL mRNA CTD PMID:16917069 NCBI chr 3:120,209,647...120,233,655
Ensembl chr 3:120,209,647...120,233,655
JBrowse link
G Maob monoamine oxidase B decreases expression EXP
ISO
Tetracycline results in decreased expression of MAOB mRNA CTD PMID:17522070, PMID:24489787 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO Tetracycline results in decreased phosphorylation of MAPK1 protein CTD PMID:25745068 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO Tetracycline results in decreased phosphorylation of MAPK3 protein CTD PMID:25745068 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mat1a methionine adenosyltransferase 1A decreases expression ISO Tetracycline results in decreased expression of MAT1A mRNA CTD PMID:24489787 NCBI chr16:18,690,649...18,709,135
Ensembl chr16:18,690,246...18,709,133
JBrowse link
G Mcph1 microcephalin 1 increases expression ISO Tetracycline results in increased expression of MCPH1 mRNA CTD PMID:16917069 NCBI chr16:75,904,087...76,110,624
Ensembl chr16:75,904,006...76,110,553
JBrowse link
G Me1 malic enzyme 1 increases expression EXP Tetracycline results in increased expression of ME1 protein CTD PMID:16538043 NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
JBrowse link
G Mgat2 alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase increases expression ISO Tetracycline results in increased expression of MGAT2 mRNA CTD PMID:16917069 NCBI chr 6:91,476,698...91,479,187
Ensembl chr 6:91,476,698...91,479,183
JBrowse link
G Mipep mitochondrial intermediate peptidase decreases expression ISO Tetracycline results in decreased expression of MIPEP mRNA CTD PMID:24489787 NCBI chr15:41,084,180...41,192,621
Ensembl chr15:41,084,206...41,190,005
JBrowse link
G Mir16 microRNA 16 increases expression EXP Tetracycline results in increased expression of MIR16 mRNA CTD PMID:17522070 NCBI chr 2:165,606,072...165,606,166
Ensembl chr 2:165,606,072...165,606,166
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions
decreases activity
ISO Tetracycline analog inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Tetracycline inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]
Tetracycline analog results in decreased activity of MMP13 protein
CTD PMID:17267227 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases activity ISO Tetracycline analog results in decreased activity of MMP2 protein CTD PMID:17267227 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions
decreases expression
decreases activity
ISO Tetracycline inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]
Tetracycline results in decreased expression of MMP3 mRNA
Tetracycline results in decreased activity of MMP3 protein
CTD PMID:17267227, PMID:24489787 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mmp8 matrix metallopeptidase 8 decreases activity ISO Tetracycline analog results in decreased activity of MMP8 protein CTD PMID:17267227 NCBI chr 8:5,768,808...5,777,741
Ensembl chr 8:5,768,811...5,778,702
JBrowse link
G Mrps12 mitochondrial ribosomal protein S12 increases expression ISO Tetracycline results in increased expression of MRPS12 mRNA CTD PMID:16917069 NCBI chr 1:86,920,679...86,923,626
Ensembl chr 1:86,920,680...86,923,575
JBrowse link
G Mtmr11 myotubularin related protein 11 increases expression ISO Tetracycline results in increased expression of MTMR11 mRNA CTD PMID:16917069 NCBI chr 2:198,301,666...198,311,787
Ensembl chr 2:198,303,168...198,311,785
JBrowse link
G Mttp microsomal triglyceride transfer protein decreases expression ISO Tetracycline results in decreased expression of MTTP mRNA CTD PMID:24489787, PMID:27089845 NCBI chr 2:243,366,181...243,407,608
Ensembl chr 2:243,366,181...243,407,608
JBrowse link
G Mug1 murinoglobulin 1 decreases expression EXP Tetracycline results in decreased expression of MUG1 mRNA CTD PMID:17522070 NCBI chr 4:154,676,382...154,729,288
Ensembl chr 4:154,391,647...154,729,310
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
increases expression
EXP Tetracycline results in decreased expression of MYC mRNA
Tetracycline results in increased expression of MYC mRNA
CTD PMID:17202758, PMID:17522070 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Ndrg2 NDRG family member 2 decreases expression EXP Tetracycline results in decreased expression of NDRG2 protein CTD PMID:16538043 NCBI chr15:28,305,820...28,314,459
Ensembl chr15:28,305,821...28,314,459
JBrowse link
G Nefh neurofilament heavy affects expression EXP Tetracycline affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G Neu3 neuraminidase 3 increases expression ISO Tetracycline results in increased expression of NEU3 mRNA CTD PMID:16917069 NCBI chr 1:164,803,574...164,814,777
Ensembl chr 1:164,803,574...164,814,651
JBrowse link
G Nfkbib NFKB inhibitor beta increases expression EXP Tetracycline results in increased expression of NFKBIB mRNA CTD PMID:17522070 NCBI chr 1:86,941,073...86,948,845
Ensembl chr 1:86,941,074...86,948,845
JBrowse link
G Notch3 notch receptor 3 decreases expression ISO Tetracycline results in decreased expression of NOTCH3 mRNA CTD PMID:28882639 NCBI chr 7:14,138,495...14,189,688
Ensembl chr 7:14,138,495...14,189,688
JBrowse link
G Notch4 notch receptor 4 decreases expression ISO Tetracycline results in decreased expression of NOTCH4 mRNA CTD PMID:28882639 NCBI chr20:4,329,794...4,353,868
Ensembl chr20:4,329,811...4,353,785
JBrowse link
G Nox4 NADPH oxidase 4 decreases expression ISO Tetracycline results in decreased expression of NOX4 mRNA CTD PMID:24489787 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Npm2 nucleophosmin/nucleoplasmin 2 increases expression ISO Tetracycline results in increased expression of NPM2 mRNA CTD PMID:16917069 NCBI chr15:52,337,457...52,345,849
Ensembl chr15:52,337,528...52,344,629
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression EXP
ISO
Tetracycline results in decreased expression of NQO1 mRNA CTD PMID:19224547, PMID:24489787 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression ISO Tetracycline results in decreased expression of NR1H4 mRNA CTD PMID:24489787 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 decreases expression ISO Tetracycline results in decreased expression of NR1I3 mRNA CTD PMID:24489787 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Nr2e3 nuclear receptor subfamily 2, group E, member 3 increases expression ISO Tetracycline results in increased expression of NR2E3 mRNA CTD PMID:16917069 NCBI chr 8:64,797,518...64,801,587
Ensembl chr 8:64,797,518...64,800,467
JBrowse link
G Nsdhl NAD(P) dependent steroid dehydrogenase-like increases expression ISO Tetracycline results in increased expression of NSDHL mRNA CTD PMID:16917069 NCBI chr  X:152,933,118...152,964,399
Ensembl chr  X:152,933,069...152,964,390
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Tetracycline results in increased expression of NUPR1 mRNA CTD PMID:17175557 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Odc1 ornithine decarboxylase 1 increases expression EXP Tetracycline results in increased expression of ODC1 mRNA CTD PMID:17522070 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Onecut1 one cut homeobox 1 decreases expression ISO Tetracycline results in decreased expression of ONECUT1 mRNA CTD PMID:24489787 NCBI chr 8:81,765,779...81,799,894
Ensembl chr 8:81,766,041...81,793,577
JBrowse link
G Osbpl3 oxysterol binding protein-like 3 decreases expression ISO Tetracycline results in decreased expression of OSBPL3 mRNA CTD PMID:16917069 NCBI chr 4:80,025,453...80,202,532
Ensembl chr 4:80,025,440...80,107,884
JBrowse link
G Osbpl8 oxysterol binding protein-like 8 decreases expression ISO Tetracycline results in decreased expression of OSBPL8 mRNA CTD PMID:16917069 NCBI chr 7:53,878,906...54,030,110
Ensembl chr 7:53,878,610...54,027,892
JBrowse link
G Otc ornithine transcarbamylase decreases expression EXP
ISO
Tetracycline results in decreased expression of OTC mRNA CTD PMID:17522070, PMID:24489787 NCBI chr  X:13,524,804...13,601,074
Ensembl chr  X:13,524,607...13,601,069
JBrowse link
G Pah phenylalanine hydroxylase decreases expression ISO Tetracycline results in decreased expression of PAH mRNA CTD PMID:24489787 NCBI chr 7:28,066,639...28,129,772
Ensembl chr 7:28,066,635...28,129,769
JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 increases expression ISO Tetracycline results in increased expression of PAK2 mRNA CTD PMID:16917069 NCBI chr11:72,829,407...72,865,815
Ensembl chr11:72,829,238...72,865,902
JBrowse link
G Paqr7 progestin and adipoQ receptor family member 7 decreases expression ISO Tetracycline results in decreased expression of PAQR7 mRNA CTD PMID:16917069 NCBI chr 5:152,708,782...152,720,230
Ensembl chr 5:152,708,775...152,720,229
JBrowse link
G Paqr9 progestin and adipoQ receptor family member 9 increases expression ISO Tetracycline results in increased expression of PAQR9 mRNA CTD PMID:16917069 NCBI chr 8:103,337,472...103,339,768
Ensembl chr 8:103,337,472...103,339,768
JBrowse link
G Pc pyruvate carboxylase increases expression ISO Tetracycline results in increased expression of PCX mRNA CTD PMID:16917069 NCBI chr 1:219,759,157...219,859,854
Ensembl chr 1:219,759,183...219,859,848
JBrowse link
G Pcdh18 protocadherin 18 increases expression ISO Tetracycline results in increased expression of PCDH18 mRNA CTD PMID:16917069 NCBI chr 2:138,819,957...138,833,932
Ensembl chr 2:138,819,960...138,833,933
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 decreases expression ISO Tetracycline results in decreased expression of PCK1 mRNA CTD PMID:24489787 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Pctp phosphatidylcholine transfer protein decreases expression ISO Tetracycline results in decreased expression of PCTP mRNA CTD PMID:16917069 NCBI chr10:77,491,445...77,537,268
Ensembl chr10:77,491,454...77,512,032
JBrowse link
G Pde4b phosphodiesterase 4B increases expression ISO Tetracycline results in increased expression of PDE4B mRNA CTD PMID:16917069 NCBI chr 5:121,759,236...122,136,814
Ensembl chr 5:121,952,977...122,136,814
JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase increases expression ISO Tetracycline results in increased expression of PECR mRNA CTD PMID:16917069 NCBI chr 9:79,601,937...79,630,547
Ensembl chr 9:79,601,901...79,630,536
JBrowse link
G Pi4kb phosphatidylinositol 4-kinase beta increases expression ISO Tetracycline results in increased expression of PI4KB mRNA CTD PMID:16917069 NCBI chr 2:196,139,724...196,172,055
Ensembl chr 2:196,139,755...196,171,713
JBrowse link
G Pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha increases expression ISO Tetracycline results in increased expression of PIK3C2A mRNA CTD PMID:16917069 NCBI chr 1:185,210,922...185,326,314
Ensembl chr 1:185,210,922...185,326,314
JBrowse link
G Pik3c2g phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma increases expression ISO Tetracycline results in increased expression of PIK3C2G mRNA CTD PMID:16917069 NCBI chr 4:173,732,196...174,102,502
Ensembl chr 4:173,732,248...174,102,496
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha increases expression ISO Tetracycline results in increased expression of PIK3CA mRNA CTD PMID:16917069 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta increases expression ISO Tetracycline results in increased expression of PIK3CB mRNA CTD PMID:16917069 NCBI chr 8:107,275,849...107,381,088
Ensembl chr 8:107,275,725...107,380,933
JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta decreases expression ISO Tetracycline results in decreased expression of PIK3CD mRNA CTD PMID:16917069 NCBI chr 5:166,602,053...166,628,028
Ensembl chr 5:166,602,053...166,628,028
JBrowse link
G Pip4k2b phosphatidylinositol-5-phosphate 4-kinase type 2 beta decreases expression ISO Tetracycline results in decreased expression of PIP4K2B mRNA CTD PMID:16917069 NCBI chr10:85,655,223...85,684,138
Ensembl chr10:85,658,324...85,684,138
JBrowse link
G Pip5k1a phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha increases expression ISO Tetracycline results in increased expression of PIP5K1A mRNA CTD PMID:16917069 NCBI chr 2:196,227,669...196,270,949
Ensembl chr 2:196,227,670...196,270,826
JBrowse link
G Pip5k1b phosphatidylinositol-4-phosphate 5-kinase type 1 beta increases expression ISO Tetracycline results in increased expression of PIP5K1B mRNA CTD PMID:16917069 NCBI chr 1:242,168,462...242,441,247
Ensembl chr 1:242,168,462...242,441,247
JBrowse link
G Pitpna phosphatidylinositol transfer protein, alpha increases expression ISO Tetracycline results in increased expression of PITPNA mRNA CTD PMID:16917069 NCBI chr10:63,731,767...63,772,049
Ensembl chr10:63,731,767...63,772,049
JBrowse link
G Pkd1l3 polycystin 1 like 3, transient receptor potential channel interacting increases expression ISO Tetracycline results in increased expression of PKD1L3 mRNA CTD PMID:16917069 NCBI chr19:41,990,249...42,054,390
Ensembl chr19:41,989,650...42,054,018
JBrowse link
G Pklr pyruvate kinase L/R decreases expression EXP Tetracycline results in decreased expression of PKLR mRNA CTD PMID:17522070, PMID:19224547 NCBI chr 2:188,449,158...188,458,034
Ensembl chr 2:188,449,210...188,459,592
JBrowse link
G Pla2g2a phospholipase A2 group IIA decreases expression ISO Tetracycline results in decreased expression of PLA2G2A mRNA CTD PMID:16917069 NCBI chr 5:157,282,650...157,285,295
Ensembl chr 5:157,282,669...157,285,328
JBrowse link
G Pla2g2d phospholipase A2, group IID decreases expression ISO Tetracycline results in decreased expression of PLA2G2D mRNA CTD PMID:16917069 NCBI chr 5:157,222,636...157,228,795
Ensembl chr 5:157,222,636...157,228,791
JBrowse link
G Plcg1 phospholipase C, gamma 1 increases expression ISO Tetracycline results in increased expression of PLCG1 mRNA CTD PMID:16917069 NCBI chr 3:156,727,642...156,758,307
Ensembl chr 3:156,727,642...156,758,307
JBrowse link
G Plcz1 phospholipase C, zeta 1 increases expression ISO Tetracycline results in increased expression of PLCZ1 mRNA CTD PMID:16917069 NCBI chr 4:174,125,072...174,181,524
Ensembl chr 4:174,125,178...174,180,729
JBrowse link
G Pld1 phospholipase D1 increases expression ISO Tetracycline results in increased expression of PLD1 mRNA CTD PMID:16917069 NCBI chr 2:113,651,967...113,849,403
Ensembl chr 2:113,652,348...113,849,403
JBrowse link
G Plg plasminogen increases expression ISO Tetracycline results in increased expression of PLG mRNA CTD PMID:16917069 NCBI chr 1:48,521,828...48,563,895
Ensembl chr 1:48,521,772...48,563,776
JBrowse link
G Plscr4 phospholipid scramblase 4 increases expression ISO Tetracycline results in increased expression of PLSCR4 mRNA CTD PMID:16917069 NCBI chr 8:99,880,073...99,917,733
Ensembl chr 8:99,880,073...99,918,825
JBrowse link
G Polr2a RNA polymerase II subunit A increases expression ISO Tetracycline results in increased expression of POLR2A mRNA CTD PMID:16917069 NCBI chr10:56,339,277...56,364,888
Ensembl chr10:56,339,284...56,365,084
JBrowse link
G Pomc proopiomelanocortin increases expression ISO Tetracycline results in increased expression of POMC mRNA CTD PMID:16917069 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
decreases expression
ISO
EXP
bicyclol inhibits the reaction [Tetracycline results in decreased expression of PPARA mRNA] CTD PMID:19224547, PMID:19427351, PMID:24489787 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppp1r3c protein phosphatase 1, regulatory subunit 3C increases expression ISO Tetracycline results in increased expression of PPP1R3C mRNA CTD PMID:16917069 NCBI chr 1:255,371,830...255,376,833
Ensembl chr 1:255,371,810...255,376,833
JBrowse link
G Prkab2 protein kinase AMP-activated non-catalytic subunit beta 2 increases expression ISO Tetracycline results in increased expression of PRKAB2 mRNA CTD PMID:16917069 NCBI chr 2:199,831,990...199,847,623
Ensembl chr 2:199,831,990...199,847,629
JBrowse link
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 increases expression ISO Tetracycline results in increased expression of PRKAG2 mRNA CTD PMID:16917069 NCBI chr 4:6,559,153...6,799,888
Ensembl chr 4:6,559,545...6,799,632
JBrowse link
G Prnp prion protein affects binding
multiple interactions
ISO Tetracycline binds to PRNP protein
Tetracycline inhibits the reaction [PRNP protein binds to PRNP protein]
CTD PMID:10903871 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316
JBrowse link
G Pten phosphatase and tensin homolog increases expression ISO Tetracycline results in increased expression of PTEN mRNA CTD PMID:16917069 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptgds prostaglandin D2 synthase increases expression ISO Tetracycline results in increased expression of PTGDS mRNA CTD PMID:16917069 NCBI chr 3:2,686,125...2,689,059
Ensembl chr 3:2,686,123...2,689,084
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Tetracycline results in decreased expression of PTGS2 mRNA CTD PMID:24489787 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptma prothymosin alpha increases expression EXP Tetracycline results in increased expression of PTMA mRNA CTD PMID:17522070 NCBI chr 9:93,545,396...93,549,436
Ensembl chr 9:93,545,396...93,549,436
JBrowse link
G Ptpmt1 protein tyrosine phosphatase, mitochondrial 1 decreases expression ISO Tetracycline results in decreased expression of PTPMT1 mRNA CTD PMID:16917069 NCBI chr 3:79,734,961...79,743,737
Ensembl chr 3:79,734,961...79,743,737
JBrowse link
G Ptpn7 protein tyrosine phosphatase, non-receptor type 7 increases expression ISO Tetracycline results in increased expression of PTPN7 mRNA CTD PMID:16917069 NCBI chr13:51,958,023...51,971,431
Ensembl chr13:51,958,834...51,972,777
JBrowse link
G Pvr PVR cell adhesion molecule increases expression EXP Tetracycline results in increased expression of PVR mRNA CTD PMID:17522070 NCBI chr 1:80,820,306...80,835,712
Ensembl chr 1:80,820,050...80,835,701
JBrowse link
G Pygl glycogen phosphorylase L decreases expression EXP Tetracycline results in decreased expression of PYGL mRNA CTD PMID:17522070 NCBI chr 6:92,597,759...92,643,734
Ensembl chr 6:92,597,706...92,643,847
JBrowse link
G Rab35 RAB35, member RAS oncogene family increases expression ISO Tetracycline results in increased expression of RAB35 mRNA CTD PMID:16917069 NCBI chr12:46,704,274...46,718,404
Ensembl chr12:46,704,275...46,718,355
JBrowse link
G Rapgef5 Rap guanine nucleotide exchange factor 5 increases expression ISO Tetracycline results in increased expression of RAPGEF5 mRNA CTD PMID:16917069 NCBI chr 6:145,387,890...145,625,243
Ensembl chr 6:145,546,595...145,625,236
JBrowse link
G Rgn regucalcin decreases expression EXP Tetracycline results in decreased expression of RGN mRNA CTD PMID:12883083 NCBI chr  X:1,833,484...1,848,904
Ensembl chr  X:1,833,492...1,848,904
JBrowse link
G Rnpep arginyl aminopeptidase increases expression ISO Tetracycline results in increased expression of RNPEP mRNA CTD PMID:16917069 NCBI chr13:52,092,863...52,124,006
Ensembl chr13:52,092,859...52,111,363
JBrowse link
G Rpl23 ribosomal protein L23 increases expression ISO Tetracycline results in increased expression of RPL23 mRNA CTD PMID:16917069 NCBI chr10:85,721,398...85,725,359
Ensembl chr10:85,721,394...85,725,429
JBrowse link
G Rps6ka2 ribosomal protein S6 kinase A2 increases expression ISO Tetracycline results in increased expression of RPS6KA2 mRNA CTD PMID:16917069 NCBI chr 1:53,219,346...53,499,445
Ensembl chr 1:53,360,157...53,499,445
JBrowse link
G Rxrg retinoid X receptor gamma increases expression ISO Tetracycline results in increased expression of RXRG mRNA CTD PMID:16917069 NCBI chr13:85,818,473...85,868,555
Ensembl chr13:85,818,427...85,868,552
JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression EXP Tetracycline results in increased expression of S100A8 mRNA CTD PMID:17522070 NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression EXP Tetracycline results in increased expression of S100A9 mRNA CTD PMID:17522070 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G Sacm1l SAC1 like phosphatidylinositide phosphatase increases expression ISO Tetracycline results in increased expression of SACM1L mRNA CTD PMID:16917069 NCBI chr 8:132,607,166...132,663,502
Ensembl chr 8:132,607,166...132,663,502
JBrowse link
G Sardh sarcosine dehydrogenase decreases expression ISO Tetracycline results in decreased expression of SARDH mRNA CTD PMID:24489787 NCBI chr 3:5,737,203...5,802,153
Ensembl chr 3:5,737,200...5,802,129
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP Tetracycline results in decreased expression of SCD mRNA CTD PMID:17202758 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Sdr9c7 short chain dehydrogenase/reductase family 9C, member 7 increases expression ISO Tetracycline results in increased expression of SDR9C7 mRNA CTD PMID:16917069 NCBI chr 7:71,152,366...71,169,510
Ensembl chr 7:71,157,664...71,170,511
JBrowse link
G Sec14l4 SEC14-like lipid binding 4 increases expression ISO Tetracycline results in increased expression of SEC14L4 mRNA CTD PMID:16917069 NCBI chr14:84,274,546...84,290,594
Ensembl chr14:84,274,550...84,319,449
JBrowse link
G Sema6d semaphorin 6D increases expression ISO Tetracycline results in increased expression of SEMA6D mRNA CTD PMID:16917069 NCBI chr 3:116,899,906...116,958,059
Ensembl chr 3:116,899,878...116,958,050
JBrowse link
G Serpina3m serpin family A member 3M increases expression ISO Tetracycline results in increased expression of SERPINA3 mRNA CTD PMID:17175557 NCBI chr 6:127,808,785...127,816,067
Ensembl chr 6:127,808,785...127,816,055
JBrowse link
G Sgms1 sphingomyelin synthase 1 increases expression ISO Tetracycline results in increased expression of SGMS1 mRNA CTD PMID:16917069 NCBI chr 1:250,692,448...250,951,685
Ensembl chr 1:250,691,370...250,951,697
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression ISO
EXP
Tetracycline results in decreased expression of SLC10A1 mRNA CTD PMID:24489787, PMID:27765674 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link
G Slc10a2 solute carrier family 10 member 2 decreases expression ISO Tetracycline results in decreased expression of SLC10A2 mRNA CTD PMID:24489787 NCBI chr16:90,324,420...90,350,254
Ensembl chr16:90,324,361...90,345,865
JBrowse link
G Slc16a7 solute carrier family 16 member 7 decreases expression ISO Tetracycline results in decreased expression of SLC16A7 mRNA CTD PMID:24489787 NCBI chr 7:68,438,341...68,606,312
Ensembl chr 7:68,446,193...68,549,763
JBrowse link
G Slc1a4 solute carrier family 1 member 4 increases expression ISO Tetracycline results in increased expression of SLC1A4 mRNA CTD PMID:16917069 NCBI chr14:104,582,884...104,612,417
Ensembl chr14:104,581,190...104,612,597
JBrowse link
G Slc22a25 solute carrier family 22, member 25 increases uptake
increases export
multiple interactions
ISO SLC22A9 protein results in increased uptake of Tetracycline
SLC22A9 protein results in increased export of Tetracycline
Tetracycline inhibits the reaction [SLC22A9 protein results in increased uptake of Anions]
CTD PMID:11855680 NCBI chr 1:224,596,886...224,698,512
Ensembl chr 1:224,596,887...224,698,514
JBrowse link
G Slc22a6 solute carrier family 22 member 6 increases export
multiple interactions
increases uptake
ISO SLC22A6 protein results in increased export of Tetracycline
Tetracycline inhibits the reaction [SLC22A6 protein results in increased uptake of Anions]
SLC22A6 protein results in increased uptake of Tetracycline
CTD PMID:11855680 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions
increases uptake
increases transport
ISO Acetaminophen inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]; Bumetanide inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]; Chloramphenicol inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]; Diclofenac inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]; Erythromycin inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]; Furosemide inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]; Ibuprofen inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]; Indomethacin inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]; Tetracycline inhibits the reaction [SLC22A7 protein results in increased uptake of Anions]
SLC22A7 protein results in increased uptake of Tetracycline
CTD PMID:11855680, PMID:15901346 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766
JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases uptake ISO SLC22A8 protein results in increased uptake of Tetracycline CTD PMID:11855680 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Slc25a15 solute carrier family 25 member 15 decreases expression ISO Tetracycline results in decreased expression of SLC25A15 mRNA CTD PMID:24489787 NCBI chr16:74,505,318...74,554,523
Ensembl chr16:74,531,564...74,554,529
JBrowse link
G Slc25a17 solute carrier family 25 member 17 decreases expression ISO Tetracycline results in decreased expression of SLC25A17 mRNA CTD PMID:24489787 NCBI chr 7:122,539,293...122,581,777
Ensembl chr 7:122,539,293...122,581,777
JBrowse link
G Slc25a20 solute carrier family 25 member 20 decreases expression ISO Tetracycline results in decreased expression of SLC25A20 mRNA CTD PMID:24489787 NCBI chr 8:117,455,308...117,476,762
Ensembl chr 8:117,455,262...117,476,734
JBrowse link
G Slc25a30 solute carrier family 25, member 30 increases expression ISO Tetracycline results in increased expression of SLC25A30 mRNA CTD PMID:16917069 NCBI chr15:57,811,612...57,834,173
Ensembl chr15:57,813,356...57,834,173
JBrowse link
G Slc27a2 solute carrier family 27 member 2 decreases expression ISO Tetracycline results in decreased expression of SLC27A2 mRNA CTD PMID:24489787 NCBI chr 3:119,014,620...119,052,531
Ensembl chr 3:119,014,620...119,052,531
JBrowse link
G Slc27a5 solute carrier family 27 member 5 increases expression
decreases expression
ISO Tetracycline results in increased expression of SLC27A5 mRNA
Tetracycline results in decreased expression of SLC27A5 protein
CTD PMID:25745068 NCBI chr 1:65,576,599...65,587,192
Ensembl chr 1:65,576,535...65,587,186
JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression EXP Tetracycline results in increased expression of SLC2A1 mRNA CTD PMID:17522070 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc2a2 solute carrier family 2 member 2 decreases expression ISO Tetracycline results in decreased expression of SLC2A2 mRNA CTD PMID:24489787 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395
JBrowse link
G Slc2a3 solute carrier family 2 member 3 increases expression EXP Tetracycline results in increased expression of SLC2A3 mRNA CTD PMID:19224547 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856
JBrowse link
G Slc2a5 solute carrier family 2 member 5 decreases expression EXP Tetracycline results in decreased expression of SLC2A5 mRNA CTD PMID:19224547 NCBI chr 5:167,142,182...167,174,203
Ensembl chr 5:167,141,875...167,174,310
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression EXP Tetracycline results in decreased expression of SLCO1B2 mRNA CTD PMID:17522070 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Sorl1 sortilin related receptor 1 decreases expression ISO Tetracycline results in decreased expression of SORL1 mRNA CTD PMID:16917069 NCBI chr 8:46,228,077...46,287,171 JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO Tetracycline results in increased expression of SPP1 mRNA CTD PMID:16917069 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 increases expression ISO Tetracycline results in increased expression of SPTLC1 mRNA CTD PMID:16917069 NCBI chr17:11,856,525...11,895,566
Ensembl chr17:11,856,525...11,895,566
JBrowse link
G Sptlc3 serine palmitoyltransferase, long chain base subunit 3 increases expression ISO Tetracycline results in increased expression of SPTLC3 mRNA CTD PMID:16917069 NCBI chr 3:132,560,437...132,689,313
Ensembl chr 3:132,560,506...132,692,737
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression
decreases expression
ISO
EXP
Tetracycline results in increased expression of SREBF1 mRNA
Tetracycline results in decreased expression of SREBF1 mRNA
CTD PMID:16917069, PMID:17202758, PMID:17522070, PMID:24469900, PMID:27089845 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G St3gal1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 increases expression ISO Tetracycline results in increased expression of ST3GAL1 mRNA CTD PMID:16917069 NCBI chr 7:107,895,045...107,963,158
Ensembl chr 7:107,895,045...107,963,142
JBrowse link
G St3gal4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 increases expression ISO Tetracycline results in increased expression of ST3GAL4 mRNA CTD PMID:16917069 NCBI chr 8:36,264,741...36,314,811
Ensembl chr 8:36,264,750...36,314,811
JBrowse link
G Stam signal transducing adaptor molecule increases expression ISO Tetracycline results in increased expression of STAM mRNA CTD PMID:16917069 NCBI chr17:81,209,795...81,256,111
Ensembl chr17:81,209,867...81,255,808
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression EXP Tetracycline results in increased expression of STAT3 mRNA CTD PMID:17522070 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Sult2b1 sulfotransferase family 2B member 1 increases expression ISO Tetracycline results in increased expression of SULT2B1 mRNA CTD PMID:16917069 NCBI chr 1:101,712,254...101,774,683
Ensembl chr 1:101,710,959...101,773,508
JBrowse link
G Tagln transgelin decreases expression ISO Tetracycline results in decreased expression of TAGLN mRNA CTD PMID:17175557 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357
JBrowse link
G Tat tyrosine aminotransferase decreases expression ISO Tetracycline results in decreased expression of TAT mRNA CTD PMID:24489787 NCBI chr19:41,675,639...41,686,195
Ensembl chr19:41,675,355...41,686,229
JBrowse link
G Tf transferrin decreases expression EXP Tetracycline results in decreased expression of TF protein CTD PMID:16538043 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Thrsp thyroid hormone responsive decreases expression ISO
EXP
Tetracycline results in decreased expression of THRSP mRNA CTD PMID:16917069, PMID:17522070 NCBI chr 1:162,381,251...162,385,575
Ensembl chr 1:162,381,253...162,385,575
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Tetracycline results in increased expression of TIMP1 mRNA CTD PMID:17522070 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression EXP Tetracycline results in increased expression of TNFRSF1A mRNA CTD PMID:17522070 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Top2a DNA topoisomerase II alpha decreases expression EXP
ISO
Tetracycline results in decreased expression of TOP2A mRNA
Tetracycline results in decreased expression of TOP2A protein
CTD PMID:19224547, PMID:23293027 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Tp53 tumor protein p53 increases expression EXP Tetracycline results in increased expression of TP53 mRNA CTD PMID:17522070 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tspo translocator protein decreases expression ISO Tetracycline results in decreased expression of TSPO mRNA CTD PMID:16917069 NCBI chr 7:124,460,358...124,470,610
Ensembl chr 7:124,460,358...124,470,609
JBrowse link
G Ttc1 tetratricopeptide repeat domain 1 increases expression ISO Tetracycline results in increased expression of TTC1 mRNA CTD PMID:16917069 NCBI chr10:29,342,495...29,367,865
Ensembl chr10:29,342,495...29,367,865
JBrowse link
G Ttr transthyretin decreases expression EXP Tetracycline results in decreased expression of TTR mRNA CTD PMID:17522070 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177
JBrowse link
G Tut1 terminal uridylyl transferase 1, U6 snRNA-specific increases expression ISO Tetracycline results in increased expression of TUT1 mRNA CTD PMID:16917069 NCBI chr 1:225,151,462...225,162,445
Ensembl chr 1:225,151,404...225,162,595
JBrowse link
G Txn1 thioredoxin 1 increases expression EXP Tetracycline results in increased expression of TXN mRNA CTD PMID:17522070 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression
decreases expression
EXP Tetracycline results in increased expression of TXNRD1 mRNA
Tetracycline results in decreased expression of TXNRD1 mRNA
CTD PMID:17522070, PMID:19224547 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase increases expression ISO Tetracycline results in increased expression of UGCG mRNA CTD PMID:16917069 NCBI chr 5:76,376,722...76,419,564
Ensembl chr 5:76,386,836...76,419,560
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 decreases expression EXP Tetracycline results in decreased expression of UGT1A6 mRNA CTD PMID:19224547 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2a3 UDP glucuronosyltransferase family 2 member A3 increases expression ISO Tetracycline results in increased expression of UGT2A3 mRNA CTD PMID:16917069 NCBI chr14:22,251,507...22,267,899
Ensembl chr14:22,192,970...22,619,968
JBrowse link
G Ugt3a2 UDP glycosyltransferase 3 family, polypeptide A2 increases expression ISO Tetracycline results in increased expression of UGT3A1 mRNA CTD PMID:16917069 NCBI chr 2:58,666,337...58,682,212
Ensembl chr 2:58,668,157...58,681,747
JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Tetracycline results in increased expression of WIPI1 mRNA CTD PMID:17175557 NCBI chr10:97,859,730...97,896,949
Ensembl chr10:97,859,727...97,896,525
JBrowse link
G Zic5 Zic family member 5 increases expression ISO Tetracycline results in increased expression of ZIC5 mRNA CTD PMID:16917069 NCBI chr15:108,891,992...108,907,601
Ensembl chr15:108,891,992...108,898,703
JBrowse link
tigecycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death multiple interactions EXP tigecycline inhibits the reaction [Lipopolysaccharides results in increased expression of BAD protein] CTD PMID:23200736 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP tigecycline inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein] CTD PMID:23200736 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions EXP tigecycline inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein] CTD PMID:23200736 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO tigecycline inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of CCL3 protein]; tigecycline inhibits the reaction [enterotoxin F, Staphylococcal results in increased expression of CCL3 protein] CTD PMID:19874226 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO tigecycline inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of CCL4 protein]; tigecycline inhibits the reaction [enterotoxin F, Staphylococcal results in increased expression of CCL4 protein] CTD PMID:19874226 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP tigecycline inhibits the reaction [Lipopolysaccharides affects the localization of CYCS protein] CTD PMID:23200736 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
tigecycline inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of IL1B protein]; tigecycline inhibits the reaction [enterotoxin F, Staphylococcal results in increased expression of IL1B protein]
Tigecycline inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Tigecycline inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
CTD PMID:19874226, PMID:23200736 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Tigecycline inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of IL6 protein]; Tigecycline inhibits the reaction [enterotoxin F, Staphylococcal results in increased expression of IL6 protein] CTD PMID:19874226 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
tigecycline inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of TNF protein]; tigecycline inhibits the reaction [enterotoxin F, Staphylococcal results in increased expression of TNF protein]
tigecycline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; tigecycline inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD PMID:19874226, PMID:23200736 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        biochemical role 19313
          metabolite 19294
            tetracyclines 494
              (4R,12aR)-4,7-bis(dimethylamino)-10,12a-dihydroxy-1,3,11,12-tetraoxo-4,4a,5,5a,6,11a-hexahydrotetracene-2-carboxamide 0
              (4S,4aR,5S,12aS)-7-chloro-4-(dimethylamino)-5,10,12a-trihydroxy-6-methylene-1,3,11,12-tetraoxo-4a,5,5a,11a-tetrahydro-4H-tetracene-2-carboxamide 0
              (4S,4aS,5aR,12aS)-9-[[2-(tert-butylamino)-1-oxoethyl]amino]-4,7-bis(dimethylamino)-10,12a-dihydroxy-1,3,11,12-tetraoxo-4,4a,5,5a,6,11a-hexahydrotetracene-2-carboxamide 0
              (4S,4aS,5aR,6S,12aS)-7-chloro-4-(dimethylamino)-6,10,12a-trihydroxy-6-methyl-1,3,11,12-tetraoxo-4a,5,5a,11a-tetrahydro-4H-tetracene-2-carboxamide 0
              (4S,4aS,6S,12aS)-7-chloro-4-(dimethylamino)-6,10,12a-trihydroxy-6-methyl-1,3,11,12-tetraoxo-4a,5,5a,11a-tetrahydro-4H-tetracene-2-carboxamide 0
              (4aS,5aR,12aS)-10,12a-dihydroxy-1,3,11,12-tetraoxo-4,4a,5,5a,6,11a-hexahydrotetracene-2-carboxamide 0
              11a-hydroxy-7-iodotetracycline zwitterion 0
              11a-hydroxychlortetracycline zwitterion 0
              11a-hydroxytetracycline 0
              11a-hydroxytigecycline(1+) 0
              12-dehydrotetracycline 0
              4-(dimethylamino)-5,10,12a-trihydroxy-6-methyl-1,3,11,12-tetraoxo-4,4a,5,5a,6,11a-hexahydrotetracene-2-carboxamide 0
              4-(dimethylamino)-6,10,12a-trihydroxy-6-methyl-1,3,11,12-tetraoxo-4a,5,5a,11a-tetrahydro-4H-tetracene-2-carboxamide 0
              4-Aminoanhydrochlortetracycline 0
              4-Dedimethylamine-4-oxo-anhydro-7-Cl-tetracycline 0
              4-amino-4-de(dimethylamino)anhydrotetracycline 0
              4-de(dimethylamino)-4-oxoanhydrotetracycline 0
              5a,11a-Dehydrochlortetracycline 0
              5a,11a-dehydrooxytetracycline 0
              7-chloro-4-(dimethylamino)-6,10,12a-trihydroxy-1,3,11,12-tetraoxo-4,4a,5,5a,6,11a-hexahydrotetracene-2-carboxamide 0
              Anhydrochlortetracycline 0
              BMS-192548 0
              DMG-MINO 0
              Pretetramid + 0
              TAN-1612 0
              a tetracycline zwittterion + 0
              anhydrotetracycline + 0
              chlortetracycline 2
              clomocycline 0
              demeclocycline + 3
              desmethylanhydrotetracycline 0
              doxycycline + 56
              guamecycline 0
              iodtetracycline(1-) + 0
              lymecycline 0
              meclocycline 6
              methacycline 0
              minocycline + 91
              oxytetracycline 10
              pipacycline 0
              pretetramide + 0
              rolitetracycline 0
              sancycline 0
              tetracycline + 384
              tigecycline + 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    main group molecular entity 19702
                      s-block molecular entity 19461
                        hydrogen molecular entity 19452
                          hydrides 18707
                            organic hydride 18269
                              organic fundamental parent 18269
                                hydrocarbon 17988
                                  cyclic hydrocarbon 17075
                                    arene 17071
                                      polycyclic arene 16889
                                        ortho-fused polycyclic arene 9650
                                          acene 7571
                                            tetracene 7568
                                              tetracyclines 494
                                                (4R,12aR)-4,7-bis(dimethylamino)-10,12a-dihydroxy-1,3,11,12-tetraoxo-4,4a,5,5a,6,11a-hexahydrotetracene-2-carboxamide 0
                                                (4S,4aR,5S,12aS)-7-chloro-4-(dimethylamino)-5,10,12a-trihydroxy-6-methylene-1,3,11,12-tetraoxo-4a,5,5a,11a-tetrahydro-4H-tetracene-2-carboxamide 0
                                                (4S,4aS,5aR,12aS)-9-[[2-(tert-butylamino)-1-oxoethyl]amino]-4,7-bis(dimethylamino)-10,12a-dihydroxy-1,3,11,12-tetraoxo-4,4a,5,5a,6,11a-hexahydrotetracene-2-carboxamide 0
                                                (4S,4aS,5aR,6S,12aS)-7-chloro-4-(dimethylamino)-6,10,12a-trihydroxy-6-methyl-1,3,11,12-tetraoxo-4a,5,5a,11a-tetrahydro-4H-tetracene-2-carboxamide 0
                                                (4S,4aS,6S,12aS)-7-chloro-4-(dimethylamino)-6,10,12a-trihydroxy-6-methyl-1,3,11,12-tetraoxo-4a,5,5a,11a-tetrahydro-4H-tetracene-2-carboxamide 0
                                                (4aS,5aR,12aS)-10,12a-dihydroxy-1,3,11,12-tetraoxo-4,4a,5,5a,6,11a-hexahydrotetracene-2-carboxamide 0
                                                11a-hydroxy-7-iodotetracycline zwitterion 0
                                                11a-hydroxychlortetracycline zwitterion 0
                                                11a-hydroxytetracycline 0
                                                11a-hydroxytigecycline(1+) 0
                                                12-dehydrotetracycline 0
                                                4-(dimethylamino)-5,10,12a-trihydroxy-6-methyl-1,3,11,12-tetraoxo-4,4a,5,5a,6,11a-hexahydrotetracene-2-carboxamide 0
                                                4-(dimethylamino)-6,10,12a-trihydroxy-6-methyl-1,3,11,12-tetraoxo-4a,5,5a,11a-tetrahydro-4H-tetracene-2-carboxamide 0
                                                4-Aminoanhydrochlortetracycline 0
                                                4-Dedimethylamine-4-oxo-anhydro-7-Cl-tetracycline 0
                                                4-amino-4-de(dimethylamino)anhydrotetracycline 0
                                                4-de(dimethylamino)-4-oxoanhydrotetracycline 0
                                                5a,11a-Dehydrochlortetracycline 0
                                                5a,11a-dehydrooxytetracycline 0
                                                7-chloro-4-(dimethylamino)-6,10,12a-trihydroxy-1,3,11,12-tetraoxo-4,4a,5,5a,6,11a-hexahydrotetracene-2-carboxamide 0
                                                Anhydrochlortetracycline 0
                                                BMS-192548 0
                                                DMG-MINO 0
                                                Pretetramid + 0
                                                TAN-1612 0
                                                a tetracycline zwittterion + 0
                                                anhydrotetracycline + 0
                                                chlortetracycline 2
                                                clomocycline 0
                                                demeclocycline + 3
                                                desmethylanhydrotetracycline 0
                                                doxycycline + 56
                                                guamecycline 0
                                                iodtetracycline(1-) + 0
                                                lymecycline 0
                                                meclocycline 6
                                                methacycline 0
                                                minocycline + 91
                                                oxytetracycline 10
                                                pipacycline 0
                                                pretetramide + 0
                                                rolitetracycline 0
                                                sancycline 0
                                                tetracycline + 384
                                                tigecycline + 9
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.