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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tetracyclines
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Accession:CHEBI:26895 term browser browse the term
Definition:A subclass of polyketides having an octahydrotetracene-2-carboxamide skeleton, substituted with many hydroxy and other groups.
Synonyms:xref_mesh: MESH:D013754


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tetracyclines term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions ISO [Resveratrol co-treated with Tetracyclines] inhibits the reaction [Paraquat results in decreased activity of CAT protein]; Tetracyclines inhibits the reaction [Paraquat results in decreased activity of CAT protein] CTD PMID:28090784 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO [Resveratrol co-treated with Tetracyclines] inhibits the reaction [Paraquat results in increased expression of CSF2 protein] CTD PMID:28090784 NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [Resveratrol co-treated with Tetracyclines] inhibits the reaction [Paraquat results in increased expression of IFNG protein] CTD PMID:28090784 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Resveratrol co-treated with Tetracyclines] affects the reaction [Paraquat affects the expression of IL10 protein] CTD PMID:28090784 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [Resveratrol co-treated with Tetracyclines] inhibits the reaction [Paraquat results in increased expression of IL1A protein] CTD PMID:28090784 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO [Resveratrol co-treated with Tetracyclines] inhibits the reaction [Paraquat results in increased expression of IL4 protein] CTD PMID:28090784 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity EXP Tetracyclines results in decreased activity of MMP9 protein CTD PMID:11172685 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [Resveratrol co-treated with Tetracyclines] inhibits the reaction [Paraquat results in increased activity of MPO protein]; Tetracyclines inhibits the reaction [Paraquat results in increased activity of MPO protein] CTD PMID:28090784 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Resveratrol co-treated with Tetracyclines] inhibits the reaction [Paraquat results in increased expression of TNF protein] CTD PMID:28090784 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
chlortetracycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity ISO Chlortetracycline results in decreased activity of CAT protein CTD PMID:30768968 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Chlortetracycline inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
demeclocycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1a interleukin 1 alpha multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Demeclocycline CTD PMID:19362101 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Demeclocycline CTD PMID:19362101 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Demeclocycline CTD PMID:19362101 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
doxycycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression EXP Doxycycline results in decreased expression of ABCB11 mRNA CTD PMID:27765674 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
increases expression
multiple interactions 		ISO Doxycycline results in decreased expression of ABCB1 protein
Doxycycline results in increased expression of ABCB1 protein
MB protein inhibits the reaction [Doxycycline results in increased expression of ABCB1 protein] 		CTD PMID:11147995 PMID:38115220 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression EXP Doxycycline results in decreased expression of ABCB4 mRNA CTD PMID:27765674 NCBI chr 4:26,106,895...26,164,440 JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression
multiple interactions 		ISO Doxycycline results in increased expression of ABCC1 protein
MB protein inhibits the reaction [Doxycycline results in increased expression of ABCC1 protein] 		CTD PMID:38115220 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 decreases expression EXP Doxycycline results in decreased expression of ABCC3 mRNA CTD PMID:27765674 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 decreases expression EXP Doxycycline results in decreased expression of ABCC4 mRNA CTD PMID:27765674 NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression EXP Doxycycline results in increased expression of ABCG5 mRNA CTD PMID:27765674 NCBI chr 6:15,717,936...15,743,376
Ensembl chr 6:15,717,936...15,743,376 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in decreased expression of ACTA2 mRNA] CTD PMID:18089841 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Ada adenosine deaminase multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of ADA mRNA] CTD PMID:18089841 NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:172,818,176...172,842,293 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases expression 		ISO [[Doxycycline results in increased expression of AHR protein] which co-treated with Tobacco Smoke Pollution] results in increased expression of CYP1B1 mRNA
[Doxycycline results in increased expression of AHR protein] which results in increased expression of CYP1B1 mRNA; Doxycycline results in increased expression of AHR protein 		CTD PMID:22273977 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Ang angiogenin multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of ANG mRNA] CTD PMID:18089841 NCBI chr15:26,786,233...26,796,883
Ensembl chr15:26,786,065...26,801,106 		JBrowse link
G Arid3a AT-rich interaction domain 3A multiple interactions ISO Doxycycline promotes the reaction [erastin results in increased expression of ARID3A mRNA] CTD PMID:38115220 NCBI chr 7:10,403,161...10,431,551
Ensembl chr 7:10,405,631...10,427,926 		JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased phosphorylation of ATF2 protein] CTD PMID:18089841 NCBI chr 3:79,125,814...79,202,896
Ensembl chr 3:79,126,705...79,202,745 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO Doxycycline inhibits the reaction [Doxorubicin results in increased expression of BAD protein] CTD PMID:17673183 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Doxycycline inhibits the reaction [Doxorubicin results in increased expression of BAX protein] CTD PMID:17673183 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Doxycycline inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein] CTD PMID:17673183 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO Doxycycline inhibits the reaction [Doxorubicin results in decreased expression of BCL2L1 protein] CTD PMID:17673183 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression EXP Doxycycline increases expression of Bnip3 mRNA in cardiac myocytes RGD PMID:25489073 RGD:11561978 NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:203,137,778...203,154,962 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Doxycycline inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Doxycycline inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein] CTD PMID:17673183 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Ccng2 cyclin G2 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of CCNG2 mRNA] CTD PMID:18089841 NCBI chr14:15,088,694...15,097,190
Ensembl chr14:15,088,695...15,096,206 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of CDKN1A mRNA] CTD PMID:18089841 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cebpd CCAAT/enhancer binding protein delta multiple interactions ISO Doxycycline promotes the reaction [erastin results in increased expression of CEBPD mRNA] CTD PMID:38115220 NCBI chr11:98,268,856...98,269,994
Ensembl chr11:98,265,651...98,280,824 		JBrowse link
G Chst4 carbohydrate sulfotransferase 4 multiple interactions ISO Doxycycline promotes the reaction [erastin results in increased expression of CHST4 mRNA] CTD PMID:38115220 NCBI chr19:54,900,914...54,911,735
Ensembl chr19:54,882,719...54,916,648 		JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 multiple interactions ISO [Doxycycline co-treated with erastin] results in increased expression of CITED2 mRNA CTD PMID:38115220 NCBI chr 1:14,132,303...14,134,746
Ensembl chr 1:14,103,457...14,134,782 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the phosphorylation of CREB1 protein; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREB1 protein binds to NR4A1 promoter]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the phosphorylation of CREB1 protein]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREB1 protein binds to NR4A1 promoter]] CTD PMID:36565944 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339 		JBrowse link
G Crebbp CREB binding protein multiple interactions ISO [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREBBP protein binds to NR4A1 promoter]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREBBP protein binds to NR4A1 promoter]] CTD PMID:36565944 NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,822,620...11,968,266 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression 		ISO [[Doxycycline results in increased expression of AHR protein] which co-treated with Tobacco Smoke Pollution] results in increased expression of CYP1B1 mRNA
[Doxycycline results in increased expression of AHR protein] which results in increased expression of CYP1B1 mRNA 		CTD PMID:22273977 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of DDIT4 mRNA] CTD PMID:18089841 NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit multiple interactions ISO [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [EZH2 protein binds to NR4A1 promoter]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [EZH2 protein binds to NR4A1 promoter]] CTD PMID:36565944 NCBI chr 4:77,624,223...77,698,598
Ensembl chr 4:77,624,223...77,687,183 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of FOS mRNA] CTD PMID:18089841 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Gabarapl1 GABA type A receptor associated protein like 1 multiple interactions ISO Doxycycline promotes the reaction [erastin results in increased expression of GABARAPL1 mRNA] CTD PMID:38115220 NCBI chr 4:164,666,332...164,675,474
Ensembl chr 4:164,666,246...164,674,578 		JBrowse link
G Gap43 growth associated protein 43 increases expression EXP Doxycycline results in increased expression of GAP43 protein CTD PMID:33798505 NCBI chr11:71,882,131...71,975,799
Ensembl chr11:71,882,131...71,975,797 		JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions ISO [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the expression of NR4A1 mRNA; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the expression of NR4A1 protein; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the methylation of NR4A1 promoter; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the phosphorylation of CREB1 protein; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREB1 protein binds to NR4A1 promoter]; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREBBP protein binds to NR4A1 promoter]; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [EZH2 protein binds to NR4A1 promoter]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the expression of NR4A1 mRNA]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the expression of NR4A1 protein]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the methylation of NR4A1 promoter]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the phosphorylation of CREB1 protein]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREB1 protein binds to NR4A1 promoter]]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREBBP protein binds to NR4A1 promoter]]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [EZH2 protein binds to NR4A1 promoter]] CTD PMID:36565944 NCBI chr 2:58,621,327...58,647,242
Ensembl chr 2:58,621,327...58,647,240 		JBrowse link
G Gem GTP binding protein overexpressed in skeletal muscle multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of GEM mRNA] CTD PMID:18089841 NCBI chr 5:30,011,641...30,022,554
Ensembl chr 5:30,011,592...30,022,542 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in decreased expression of GJA1 mRNA] CTD PMID:18089841 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689 		JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions
decreases expression 		ISO MB protein promotes the reaction [Doxycycline results in decreased expression of GPX4 protein] CTD PMID:38115220 NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Doxycycline inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
G Hmga2 high mobility group AT-hook 2 multiple interactions ISO Doxycycline promotes the reaction [erastin results in increased expression of HMGA2 mRNA] CTD PMID:38115220 NCBI chr 7:57,762,710...57,884,555
Ensembl chr 7:57,765,675...57,880,341 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
increases response to substance 		ISO Doxycycline results in increased expression of HMOX1 protein
Doxycycline promotes the reaction [erastin results in increased expression of HMOX1 mRNA]; ferrostatin-1 inhibits the reaction [HMOX1 protein results in increased susceptibility to Doxycycline]; MB protein promotes the reaction [Doxycycline results in increased expression of HMOX1 protein] 		CTD PMID:38115220 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Doxycycline analog inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA] CTD PMID:17267227 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Doxycycline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:25977597 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Krt5 keratin 5 multiple interactions ISO Doxycycline promotes the reaction [erastin results in increased expression of KRT5 mRNA] CTD PMID:38115220 NCBI chr 7:134,724,840...134,730,569
Ensembl chr 7:134,724,840...134,730,569 		JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of LCN2 mRNA] CTD PMID:18089841 NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842 		JBrowse link
G Map3k6 mitogen-activated protein kinase kinase kinase 6 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MAP3K6 mRNA] CTD PMID:18089841 NCBI chr 5:150,724,029...150,736,113
Ensembl chr 5:150,724,216...150,736,111 		JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MAP3K8 mRNA] CTD PMID:18089841 NCBI chr17:58,078,175...58,098,455
Ensembl chr17:58,078,320...58,098,452 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK14 protein] CTD PMID:18089841 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294 		JBrowse link
G Mb myoglobin increases response to substance
increases expression
multiple interactions 		ISO MB protein results in increased susceptibility to Doxycycline
Doxycycline results in increased expression of MB protein
Doxycycline promotes the reaction [erastin results in increased expression of MB mRNA]; MB protein inhibits the reaction [Doxycycline results in increased expression of ABCB1 protein]; MB protein inhibits the reaction [Doxycycline results in increased expression of ABCC1 protein]; MB protein promotes the reaction [Doxycycline results in decreased expression of GPX4 protein]; MB protein promotes the reaction [Doxycycline results in increased expression of HMOX1 protein] 		CTD PMID:38115220 NCBI chr 7:110,640,511...110,647,742
Ensembl chr 7:110,640,512...110,647,958 		JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions
decreases activity
increases expression 		ISO Doxycycline analog inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]
Doxycycline analog results in decreased activity of MMP13 protein
Doxycycline results in increased expression of MMP13 mRNA 		CTD PMID:17267227 PMID:20338993 NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases activity
decreases expression 		ISO
EXP 		Doxycycline inhibits the reaction [Isoproterenol results in increased activity of MMP2]
Doxycycline analog results in decreased activity of MMP2 protein
Doxycycline results in decreased expression of MMP2 protein
Doxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP2 protein]; Doxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein]
Doxycycline inhibits the reaction [angiotensin I (1-7) results in increased activity of MMP2 protein]; Doxycycline inhibits the reaction [Lead results in increased expression of and results in increased activity of MMP2 protein]
Doxycycline results in decreased activity of MMP2 protein 		CTD PMID:17267227 PMID:17498959 PMID:18089841 PMID:18178469 PMID:18836702 More... NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions
decreases activity 		ISO Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]
Doxycycline results in decreased activity of MMP3 protein
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MMP3 mRNA] 		CTD PMID:17267227 PMID:18089841 NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826 		JBrowse link
G Mmp8 matrix metallopeptidase 8 decreases activity ISO Doxycycline analog results in decreased activity of MMP8 protein CTD PMID:17267227 NCBI chr 8:13,008,873...13,018,729
Ensembl chr 8:13,008,890...13,018,729 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
decreases activity 		ISO
EXP 		Doxycycline inhibits the reaction [Isoproterenol results in increased activity of MMP9]; Doxycycline inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 mRNA]; Doxycycline inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 protein]
Doxycycline results in decreased expression of MMP9 protein
Doxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]; Doxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]
Doxycycline inhibits the reaction [angiotensin I (1-7) results in increased activity of MMP9 protein]
Doxycycline results in decreased activity of MMP9 protein 		CTD PMID:15131573 PMID:17498959 PMID:18089841 PMID:18178469 PMID:19375915 More... NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mt2 metallothionein 2 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MT2 mRNA] CTD PMID:18089841 NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709 		JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MYH7 mRNA] CTD PMID:18089841 NCBI chr15:32,416,525...32,439,851
Ensembl chr15:32,416,527...32,438,194 		JBrowse link
G Nefh neurofilament heavy chain increases expression EXP Doxycycline results in increased expression of NEFH protein CTD PMID:33798505 NCBI chr14:84,044,428...84,054,413
Ensembl chr14:84,044,023...84,054,417 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression 		ISO Doxycycline results in decreased stability of and results in decreased expression of NOS2 mRNA
Doxycycline results in decreased expression of NOS2 protein 		CTD PMID:16365451 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of NOX4 mRNA] CTD PMID:18089841 NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the expression of NR4A1 mRNA; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the expression of NR4A1 protein; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the methylation of NR4A1 promoter; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREB1 protein binds to NR4A1 promoter]; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREBBP protein binds to NR4A1 promoter]; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [EZH2 protein binds to NR4A1 promoter]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the expression of NR4A1 mRNA]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the expression of NR4A1 protein]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the methylation of NR4A1 promoter]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREB1 protein binds to NR4A1 promoter]]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREBBP protein binds to NR4A1 promoter]]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [EZH2 protein binds to NR4A1 promoter]] CTD PMID:36565944 NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:134,247,192...134,268,041 		JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 increases phosphorylation EXP Doxycycline results in increased phosphorylation of NTRK1 protein CTD PMID:33798505 NCBI chr 2:175,534,844...175,551,664
Ensembl chr 2:175,534,844...175,551,787 		JBrowse link
G Osmr oncostatin M receptor multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of OSMR mRNA] CTD PMID:18089841 NCBI chr 2:57,634,517...57,688,802
Ensembl chr 2:57,634,517...57,688,561 		JBrowse link
G Pla2g7 phospholipase A2 group VII multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of PLA2G7 mRNA] CTD PMID:18089841 NCBI chr 9:24,859,491...24,901,747
Ensembl chr 9:24,859,502...24,901,747 		JBrowse link
G Rnasel ribonuclease L multiple interactions ISO Doxycycline promotes the reaction [erastin results in increased expression of RNASEL mRNA] CTD PMID:38115220 NCBI chr13:68,446,641...68,460,804
Ensembl chr13:68,446,882...68,459,557 		JBrowse link
G Rnf38 ring finger protein 38 multiple interactions ISO [Doxycycline co-treated with erastin] results in increased expression of RNF38 mRNA CTD PMID:38115220 NCBI chr 5:63,154,507...63,263,138
Ensembl chr 5:63,154,507...63,263,137 		JBrowse link
G S100a8 S100 calcium binding protein A8 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of S100A8 mRNA] CTD PMID:18089841 NCBI chr 2:178,464,095...178,465,223
Ensembl chr 2:178,464,702...178,465,221 		JBrowse link
G S100a9 S100 calcium binding protein A9 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of S100A9 mRNA] CTD PMID:18089841 NCBI chr 2:178,487,941...178,490,622
Ensembl chr 2:178,487,941...178,490,870 		JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of S1PR1 mRNA]; Doxycycline inhibits the reaction [Isoproterenol results in increased expression of S1PR1 protein] CTD PMID:18089841 NCBI chr 2:206,309,715...206,314,070
Ensembl chr 2:205,900,836...206,328,689 		JBrowse link
G Serpina3n serpin family A member 3N multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of SERPINA3N mRNA] CTD PMID:18089841 NCBI chr 6:129,088,392...129,095,950
Ensembl chr 6:129,088,398...129,097,415 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP Doxycycline results in decreased expression of SLC10A1 mRNA CTD PMID:27765674 NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Doxycycline inhibits the reaction [SLC22A6 protein results in increased uptake of Anions] CTD PMID:11855680 NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311 		JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 decreases expression EXP Doxycycline results in decreased expression of SLCO1A1 mRNA CTD PMID:27765674 NCBI chr 4:176,606,924...176,682,027
Ensembl chr 4:176,607,687...176,681,992 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor multiple interactions ISO Doxycycline promotes the reaction [erastin results in increased expression of SLPI mRNA] CTD PMID:38115220 NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:173,501,573...173,503,822 		JBrowse link
G Smyd1 SET and MYND domain containing 1 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in decreased expression of SMYD1 mRNA] CTD PMID:18089841 NCBI chr 4:104,757,281...104,811,307
Ensembl chr 4:104,760,475...104,870,081 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of SOCS3 mRNA] CTD PMID:18089841 NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO Doxycycline inhibits the reaction [Doxorubicin results in decreased expression of SOD1 protein] CTD PMID:17673183 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Syn1 synapsin I increases expression EXP Doxycycline results in increased expression of SYN1 protein CTD PMID:33798505 NCBI chr  X:3,725,745...3,780,940
Ensembl chr  X:3,725,714...3,780,938 		JBrowse link
G Tardbp TAR DNA binding protein multiple interactions
decreases expression 		ISO [Doxycycline analog results in decreased expression of TARDBP protein] inhibits the reaction [sodium arsenite affects the localization of TARDBP protein] CTD PMID:24019256 NCBI chr 5:164,330,452...164,348,435
Ensembl chr 5:164,334,924...164,345,204 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of TGFBR2 mRNA] CTD PMID:18089841 NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:124,674,986...124,761,469 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Doxycycline inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of TNF protein]; Doxycycline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:16134060 PMID:25977597 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of TRP53INP1 mRNA] CTD PMID:18089841 NCBI chr 5:29,051,267...29,069,486
Ensembl chr 5:29,051,264...29,069,484 		JBrowse link
meclocycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO meclocycline results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO meclocycline results in decreased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO meclocycline results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO meclocycline results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884 		JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO meclocycline results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO meclocycline results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
minocycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aif1 allograft inflammatory factor 1 multiple interactions
decreases expression 		ISO Minocycline affects the reaction [GPX1 protein affects the expression of AIF1 protein]; Minocycline inhibits the reaction [Methamphetamine results in increased expression of AIF1 protein]; Minocycline inhibits the reaction [Morphine results in increased expression of AIF1 protein]
Minocycline results in decreased expression of AIF1 protein 		CTD PMID:32916201 PMID:36682417 PMID:37394652 NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,652,243...3,657,339 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions
decreases secretion 		EXP
ISO 		Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of and results in increased localization of AIFM1 protein]
Minocycline results in decreased secretion of AIFM1 protein
Minocycline inhibits the reaction [Kainic Acid results in increased localization of AIFM1 protein] 		CTD PMID:12930891 PMID:16469440 NCBI chr  X:132,528,107...132,567,237
Ensembl chr  X:132,528,107...132,567,237 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO
EXP 		Minocycline inhibits the reaction [APP gene mutant form results in increased phosphorylation of EIF2S1 protein]
Minocycline inhibits the reaction [APP protein alternative form results in increased activity of CASP12 protein]; Minocycline inhibits the reaction [APP protein alternative form results in increased phosphorylation of EIF2AK2 protein]; Minocycline inhibits the reaction [APP protein alternative form results in increased phosphorylation of EIF2S1 protein] 		CTD PMID:17406652 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971 		JBrowse link
G Atf3 activating transcription factor 3 multiple interactions EXP Minocycline inhibits the reaction [Paclitaxel results in increased expression of ATF3 protein] CTD PMID:21050491 NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions EXP Minocycline inhibits the reaction [Paraquat results in increased expression of ATF6 protein] CTD PMID:22245251 NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha multiple interactions ISO Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP5F1A protein] CTD PMID:23562983 NCBI chr18:73,567,537...73,575,473
Ensembl chr18:73,567,526...73,575,922 		JBrowse link
G Atp5pd ATP synthase peripheral stalk subunit d multiple interactions EXP Minocycline inhibits the reaction [cypermethrin results in decreased expression of ATP5PD protein] CTD PMID:21561882 NCBI chr10:101,156,673...101,161,926
Ensembl chr10:101,156,673...101,162,954 		JBrowse link
G Bace1 beta-secretase 1 multiple interactions ISO Minocycline inhibits the reaction [Copper results in increased expression of BACE1 mRNA] CTD PMID:18583042 NCBI chr 8:55,038,842...55,061,138
Ensembl chr 8:55,038,823...55,064,918 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions EXP [Minocycline results in increased expression of BCL2 protein] which binds to BAK1 protein CTD PMID:15004018 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
decreases expression 		EXP
ISO 		[Minocycline results in increased expression of BCL2 protein] which binds to BAX protein; Minocycline inhibits the reaction [Sodium Azide affects the localization of BAX protein]
Minocycline inhibits the reaction [Rotenone results in increased expression of BAX protein]
Minocycline results in decreased expression of BAX protein 		CTD PMID:15004018 PMID:15172883 PMID:33402167 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression 		ISO
EXP 		[Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2 protein] results in increased expression of BCL2 mRNA; [Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of BCL2 protein
Minocycline results in increased expression of BCL2 mRNA; Minocycline results in increased expression of BCL2 protein
[Minocycline results in increased expression of BCL2 protein] which binds to BAK1 protein; [Minocycline results in increased expression of BCL2 protein] which binds to BAX protein; [Minocycline results in increased expression of BCL2 protein] which binds to BID protein; Sodium Azide inhibits the reaction [Minocycline results in increased expression of BCL2 protein] 		CTD PMID:15004018 PMID:19807907 PMID:20606027 PMID:20711699 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO Minocycline inhibits the reaction [Rotenone results in decreased expression of BCL2L1 protein] CTD PMID:33402167 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO
EXP 		Minocycline results in decreased activity of and results in decreased cleavage of BID protein
[Minocycline results in increased expression of BCL2 protein] which binds to BID protein; Minocycline inhibits the reaction [HTT protein mutant form results in increased cleavage of and results in increased activity of BID protein] 		CTD PMID:12930891 PMID:15004018 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 multiple interactions ISO Minocycline inhibits the reaction [T-2 Toxin results in increased expression of BTG2 mRNA]; Minocycline inhibits the reaction [T-2 Toxin results in increased expression of BTG2 protein] CTD PMID:39147216 NCBI chr13:48,083,931...48,087,690
Ensembl chr13:48,083,931...48,087,690 		JBrowse link
G Casp1 caspase 1 multiple interactions
decreases expression
decreases activity 		EXP
ISO 		Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP1 protein]
Minocycline results in decreased expression of CASP1 mRNA; Minocycline results in decreased expression of CASP1 protein
Minocycline results in decreased activity of CASP1 protein 		CTD PMID:12930891 PMID:14998631 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275 		JBrowse link
G Casp12 caspase 12 multiple interactions
decreases expression 		EXP Minocycline inhibits the reaction [APP protein alternative form results in increased activity of CASP12 protein]; Minocycline results in decreased degradation of [Paraquat results in increased expression of CASP12 protein]
Minocycline results in decreased expression of CASP12 mRNA; Minocycline results in decreased expression of CASP12 protein 		CTD PMID:14998631 PMID:17406652 PMID:22245251 NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:10,926,994...10,954,442 		JBrowse link
G Casp3 caspase 3 decreases activity
multiple interactions
decreases expression 		ISO
EXP 		Minocycline results in decreased activity of CASP3 protein
Minocycline pretreatment inhibits the reaction [azide increases activity of Casp3 protein in kidney proximal tubular epithelial cells]
Minocycline results in decreased expression of CASP3 mRNA
Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP3 protein]; Minocycline inhibits the reaction [Morphine results in increased activity of CASP3 protein]; Minocycline inhibits the reaction [Paraquat results in increased cleavage of CASP3 protein]; Minocycline inhibits the reaction [sodium arsenite results in increased cleavage of CASP3 protein]; Minocycline inhibits the reaction [Sodium Azide results in increased activity of CASP3 protein]; Minocycline results in decreased expression of and results in decreased activity of CASP3 protein
Minocycline inhibits the reaction [Kainic Acid results in increased activity of CASP3 protein]; Minocycline inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]; Minocycline inhibits the reaction [Rotenone results in increased cleavage of CASP3 protein]; Minocycline results in decreased activity of and results in decreased cleavage of CASP3 protein 		CTD
RGD		 PMID:12930891 PMID:14588118 PMID:14998631 PMID:15004018 PMID:15304547 More... RGD:1581919 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp7 caspase 7 decreases expression
multiple interactions 		EXP Minocycline results in decreased expression of CASP7 mRNA
Minocycline results in decreased expression of and results in decreased activity of CASP7 protein 		CTD PMID:14998631 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512 		JBrowse link
G Casp8 caspase 8 multiple interactions
decreases expression 		EXP Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP8 protein]; Minocycline inhibits the reaction [sodium arsenite results in increased cleavage of CASP8 protein]; Minocycline results in decreased expression of and results in decreased activity of CASP8 protein
Minocycline results in decreased expression of CASP8 mRNA 		CTD PMID:12930891 PMID:14998631 PMID:35939230 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 decreases activity
decreases expression
multiple interactions 		ISO
EXP 		Minocycline results in decreased activity of CASP9 protein
Minocycline results in decreased expression of CASP9 mRNA
Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP9 protein]; Minocycline results in decreased expression of and results in decreased activity of CASP9 protein 		CTD PMID:12930891 PMID:14998631 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions 		ISO Minocycline results in decreased expression of CCL2 protein
Minocycline inhibits the reaction [lead acetate results in increased secretion of CCL2 protein] 		CTD PMID:20116850 PMID:24530660 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression
multiple interactions 		ISO Minocycline results in decreased expression of CCL3 protein
Minocycline inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased secretion of CCL3 protein] 		CTD PMID:20116850 PMID:35351628 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Minocycline results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression
multiple interactions 		ISO Minocycline results in decreased expression of CCL5 protein
Minocycline inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased secretion of CCL5 protein] 		CTD PMID:20116850 PMID:35351628 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884 		JBrowse link
G Cd68 Cd68 molecule multiple interactions ISO Minocycline affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CD68 protein]; Minocycline inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CD68 mRNA] CTD PMID:35351628 NCBI chr10:54,880,562...54,882,441
Ensembl chr10:54,880,563...54,882,540 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Minocycline results in increased expression of CDKN1B mRNA; Minocycline results in increased expression of CDKN1B protein CTD PMID:21719015 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498 		JBrowse link
G Cldn5 claudin 5 increases expression EXP minocycline increases expression of claudin-5 protein in left corpus callosum of rats with right carotid artery occlusion RGD PMID:29486300 RGD:27095946 NCBI chr11:95,717,172...95,718,598
Ensembl chr11:95,717,176...95,719,322 		JBrowse link
G Cox5a cytochrome c oxidase subunit 5A multiple interactions ISO Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX5A protein] CTD PMID:23562983 NCBI chr 8:66,818,284...66,829,691
Ensembl chr 8:66,818,196...66,830,279 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions
decreases secretion 		ISO
EXP 		Minocycline inhibits the reaction [Kainic Acid results in increased localization of CYCS protein]
Minocycline results in decreased secretion of CYCS protein
Minocycline inhibits the reaction [Cocaine results in increased secretion of CYCS protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of CYCS protein] 		CTD PMID:12930891 PMID:14998631 PMID:15172883 PMID:16469440 PMID:21424555 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP Minocycline inhibits the reaction [Paraquat results in increased expression of DDIT3 protein] CTD PMID:22245251 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein decreases secretion
multiple interactions 		ISO
EXP 		Minocycline results in decreased secretion of DIABLO protein
Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of DIABLO protein]; Minocycline results in decreased secretion of and results in decreased expression of DIABLO protein 		CTD PMID:12930891 PMID:14998631 NCBI chr12:38,716,668...38,731,285
Ensembl chr12:38,716,668...38,731,265 		JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 multiple interactions ISO Minocycline inhibits the reaction [Rotenone results in decreased expression of DLG1 protein] CTD PMID:33402167 NCBI chr11:82,416,853...82,607,797
Ensembl chr11:82,416,853...82,607,797 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions ISO Minocycline affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of DLG4 protein] CTD PMID:35351628 NCBI chr10:55,239,397...55,267,780
Ensembl chr10:55,236,869...55,265,839 		JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase multiple interactions ISO Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DLST protein] CTD PMID:23562983 NCBI chr 6:110,489,576...110,512,841
Ensembl chr 6:110,489,392...110,514,357 		JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 multiple interactions
increases expression 		ISO [[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] inhibits the reaction [Oxygen deficiency results in increased stability of HIF1A protein]; [[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] results in increased degradation of HIF1A protein CTD PMID:24292262 NCBI chr19:69,765,276...69,804,681 JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 multiple interactions EXP Minocycline inhibits the reaction [APP protein alternative form results in increased phosphorylation of EIF2AK2 protein] CTD PMID:17406652 NCBI chr 6:21,941,147...21,977,115
Ensembl chr 6:21,952,631...21,977,116 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation EXP Minocycline results in increased phosphorylation of EIF2AK3 protein CTD PMID:22245251 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions
increases phosphorylation 		ISO
EXP 		Minocycline inhibits the reaction [APP gene mutant form results in increased phosphorylation of EIF2S1 protein]
Minocycline results in increased phosphorylation of EIF2S1 protein
Minocycline inhibits the reaction [APP protein alternative form results in increased phosphorylation of EIF2S1 protein] 		CTD PMID:17406652 PMID:22245251 NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649 		JBrowse link
G Eno1 enolase 1 multiple interactions ISO Minocycline inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ENO1 protein]; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of ENO1 protein] CTD PMID:23562983 NCBI chr 5:166,002,867...166,014,252
Ensembl chr 3:77,946,261...77,986,003
Ensembl chr 5:77,946,261...77,986,003 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases phosphorylation EXP Minocycline results in increased phosphorylation of ERN1 protein CTD PMID:22245251 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791 		JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 multiple interactions ISO Minocycline inhibits the reaction [FMR1 gene mutant form results in increased expression of and results in increased activity of MMP9 protein] CTD PMID:18835858 NCBI chr  X:152,284,857...152,322,686
Ensembl chr  X:152,284,841...152,322,675 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO Minocycline inhibits the reaction [Rotenone results in increased expression of GFAP protein] CTD PMID:33402167 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685 		JBrowse link
G Gjc2 gap junction protein, gamma 2 multiple interactions EXP Minocycline inhibits the reaction [cypermethrin results in increased expression of GJC2 protein modified form] CTD PMID:21561882 NCBI chr10:44,462,203...44,470,924
Ensembl chr10:44,462,054...44,470,340 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO Minocycline affects the reaction [GPX1 protein affects the expression of AIF1 protein]; Minocycline affects the reaction [GPX1 protein affects the phosphorylation of MAPK1 protein]; Minocycline affects the reaction [GPX1 protein affects the phosphorylation of MAPK3 protein] CTD PMID:36682417 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions EXP Minocycline inhibits the reaction [Poly C results in increased expression of GRIA1 mRNA] CTD PMID:19660546 NCBI chr10:41,710,540...42,030,105
Ensembl chr10:41,711,080...42,030,309 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions EXP Minocycline inhibits the reaction [Poly C results in increased expression of GRIN2A mRNA] CTD PMID:19660546 NCBI chr10:6,136,458...6,560,003
Ensembl chr10:6,138,037...6,551,378 		JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C multiple interactions EXP Minocycline inhibits the reaction [Poly C results in increased expression of GRIN2C mRNA] CTD PMID:19660546 NCBI chr10:100,987,410...101,006,064
Ensembl chr10:100,987,513...101,005,409 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP minocycline increases expression of glutathione S-transferase pi protein in left corpus callosum of rats with right carotid artery occlusion RGD PMID:29486300 RGD:27095946 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases degradation 		ISO [[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] inhibits the reaction [Oxygen deficiency results in increased stability of HIF1A protein]; [[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] results in increased degradation of HIF1A protein; Minocycline inhibits the reaction [Oxygen deficiency results in increased stability of HIF1A protein]; Minocycline promotes the reaction [HIF1A protein binds to VHL protein]
Minocycline results in increased degradation of HIF1A protein 		CTD PMID:24292262 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Hp haptoglobin increases expression EXP minocycline increases expression of zonulin protein in left corpus callosum of rats with right carotid artery occlusion RGD PMID:29486300 RGD:27095946 NCBI chr19:54,449,151...54,453,701
Ensembl chr19:54,446,217...54,467,518 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Minocycline inhibits the reaction [Paraquat results in increased expression of HSPA5 protein] CTD PMID:22245251 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions EXP Minocycline inhibits the reaction [cypermethrin results in increased expression of HSPD1 protein] CTD PMID:21561882 NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037 		JBrowse link
G Htt huntingtin multiple interactions EXP Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP1 protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP3 protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP8 protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP9 protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased cleavage of and results in increased activity of BID protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of and results in increased localization of AIFM1 protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of CYCS protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of DIABLO protein] CTD PMID:12930891 NCBI chr14:80,070,456...80,219,668
Ensembl chr14:80,070,456...80,219,668 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression EXP Minocycline results in decreased expression of ICAM1 protein CTD PMID:15172883 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Minocycline inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG mRNA]
[Minocycline co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA 		CTD PMID:19285099 PMID:29594315 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression 		ISO
EXP 		Minocycline promotes the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA]
Minocycline results in increased expression of IL10 mRNA 		CTD PMID:14588118 PMID:22024136 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
affects secretion 		ISO
EXP 		Minocycline inhibits the reaction [Cisplatin results in increased expression of IL1B mRNA]; Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; Minocycline inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Minocycline inhibits the reaction [Morphine results in increased expression of IL1B protein]; Minocycline inhibits the reaction [Paraquat results in increased expression of IL1B protein]; Minocycline inhibits the reaction [Rotenone results in increased expression of IL1B mRNA]; Minocycline inhibits the reaction [T-2 Toxin results in increased expression of IL1B mRNA]
Minocycline inhibits the reaction [Kainic Acid results in increased secretion of IL1B protein]; Minocycline inhibits the reaction [lead acetate results in increased secretion of IL1B protein]; Minocycline inhibits the reaction [manganese chloride results in increased expression of IL1B protein]; Minocycline inhibits the reaction [Paclitaxel results in increased expression of IL1B protein]; Minocycline inhibits the reaction [Toluene results in increased expression of IL1B mRNA]
Minocycline affects the secretion of IL1B protein 		CTD PMID:11306611 PMID:16386803 PMID:18836210 PMID:19285099 PMID:22024136 More... NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Minocycline co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression 		ISO
EXP 		Minocycline inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased secretion of IL6 protein]; Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of IL6 mRNA]; Minocycline inhibits the reaction [Dietary Fats results in increased expression of IL6 protein]; Minocycline inhibits the reaction [lead acetate results in increased secretion of IL6 protein]; Minocycline inhibits the reaction [Methamphetamine results in increased secretion of IL6 protein]; Minocycline inhibits the reaction [Morphine results in increased expression of IL6 protein]; Minocycline inhibits the reaction [Paraquat results in increased expression of IL6 protein]; Minocycline inhibits the reaction [T-2 Toxin results in increased expression of IL6 mRNA]
minocycline inhibits the reaction [LPS increases expression of IL6 mRNA in hypothalamic microglia of alcohol fed neonates]
minocycline inhibits the reaction [ethanol increases expression of IL6 mRNA and protein in hypothalamic microglia] 		CTD
RGD		 PMID:19285099 PMID:21719015 PMID:24530660 PMID:32916201 PMID:35351628 More... RGD:598092506, RGD:598092506 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Minocycline results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221 		JBrowse link
G Ina internexin neuronal intermediate filament protein, alpha multiple interactions EXP Minocycline inhibits the reaction [cypermethrin results in increased expression of INA protein] CTD PMID:21561882 NCBI chr 1:255,838,129...255,849,680
Ensembl chr 1:255,838,129...255,849,680 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO Minocycline inhibits the reaction [Paraquat results in increased expression of ITGAM protein]; Minocycline inhibits the reaction [Paraquat results in increased phosphorylation of ITGAM protein]; Minocycline inhibits the reaction [T-2 Toxin results in increased expression of ITGAM protein] CTD PMID:36775139 PMID:38189626 PMID:39147216 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Minocycline results in decreased phosphorylation of and results in decreased activity of and results in decreased expression of JUN protein CTD PMID:17872917 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions 		ISO Minocycline results in increased phosphorylation of MAPK1 protein
Minocycline affects the reaction [GPX1 protein affects the phosphorylation of MAPK1 protein] 		CTD PMID:36682417 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation 		ISO Minocycline affects the reaction [GPX1 protein affects the phosphorylation of MAPK3 protein]
Minocycline results in increased phosphorylation of MAPK3 protein 		CTD PMID:36682417 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases phosphorylation ISO Minocycline results in decreased phosphorylation of MAPK8 protein CTD PMID:17872917 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mapkapk5 MAPK activated protein kinase 5 multiple interactions EXP Minocycline inhibits the reaction [cypermethrin results in increased expression of MAPKAPK5 protein] CTD PMID:21561882 NCBI chr12:40,654,220...40,673,740
Ensembl chr12:40,654,423...40,677,170 		JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase multiple interactions EXP Minocycline inhibits the reaction [Paclitaxel results in increased expression of MLKL protein] CTD PMID:38459698 NCBI chr19:56,186,860...56,213,886
Ensembl chr19:56,186,860...56,213,858 		JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression
multiple interactions 		ISO Minocycline results in increased expression of MMP13 mRNA
Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP13 mRNA] 		CTD PMID:19285099 PMID:20338993 NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
multiple interactions
decreases activity 		ISO
EXP 		Minocycline results in decreased expression of MMP2 protein
Minocycline inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 mRNA]
Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP2 mRNA]; Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP2 protein]
Minocycline results in decreased activity of MMP2 protein 		CTD PMID:11835378 PMID:14508231 PMID:16846501 PMID:19285099 PMID:24292262 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP3 mRNA] CTD PMID:19285099 NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases activity
decreases expression 		ISO
EXP 		Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP9 mRNA]; Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP9 protein]; Minocycline inhibits the reaction [FMR1 gene mutant form results in increased expression of and results in increased activity of MMP9 protein]
Minocycline results in decreased activity of MMP9 protein
Minocycline results in decreased expression of MMP9 protein 		CTD PMID:16846501 PMID:18835858 PMID:19285099 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO Minocycline affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:69,850,420...69,868,302
Ensembl chr13:69,850,420...69,868,502 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO Minocycline inhibits the reaction [Paraquat affects the localization of NCF1 protein] CTD PMID:38189626 NCBI chr12:28,121,816...28,131,080
Ensembl chr12:28,121,366...28,131,079 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Minocycline inhibits the reaction [Morphine results in increased expression of NLRP3 protein] CTD PMID:37394652 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP 		Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of NOS2 mRNA]; Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of NOS2 protein]; Minocycline inhibits the reaction [Morphine results in increased expression of NOS2 protein]; Minocycline inhibits the reaction [Paraquat results in increased expression of NOS2 protein]; Minocycline inhibits the reaction [Rotenone results in increased expression of NOS2 mRNA]; Minocycline inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA]
Minocycline inhibits the reaction [lead acetate results in increased expression of NOS2 protein]; Minocycline inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Minocycline inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Minocycline inhibits the reaction [manganese chloride results in increased expression of NOS2 protein] 		CTD PMID:15485488 PMID:18836210 PMID:19285099 PMID:22952811 PMID:33402167 More... NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Ocln occludin increases expression EXP minocycline increases expression of occludin protein in left corpus callosum of rats with right carotid artery occlusion RGD PMID:29486300 RGD:27095946 NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411 		JBrowse link
G Pafah1b2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 multiple interactions EXP Minocycline inhibits the reaction [cypermethrin results in decreased expression of PAFAH1B2 protein] CTD PMID:21561882 NCBI chr 8:55,156,778...55,208,800
Ensembl chr 8:55,156,779...55,176,836 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions ISO Minocycline inhibits the reaction [Paraquat results in increased expression of PDK1 protein] CTD PMID:38189626 NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:77,113,473...77,144,145 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta multiple interactions ISO Minocycline inhibits the reaction [Paraquat results in increased expression of PIK3CB protein] CTD PMID:38189626 NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:108,474,019...108,579,331 		JBrowse link
G Prdx2 peroxiredoxin 2 multiple interactions ISO Minocycline inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PRDX2 protein] CTD PMID:23562983 NCBI chr19:40,085,788...40,091,083
Ensembl chr19:40,084,430...40,091,006 		JBrowse link
G Prdx3 peroxiredoxin 3 multiple interactions ISO Minocycline inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PRDX3 protein]; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PRDX3 protein] CTD PMID:23562983 NCBI chr 1:269,987,691...270,000,111
Ensembl chr 1:269,987,685...270,000,300 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO Minocycline inhibits the reaction [PRKN gene mutant form results in increased susceptibility to Rotenone] CTD PMID:16573651 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:51,210,330...52,430,304 		JBrowse link
G Prtn3 proteinase 3 increases expression ISO Minocycline results in increased expression of PRTN3 protein CTD PMID:12900849 NCBI chr 7:10,472,750...10,482,037
Ensembl chr 7:10,472,755...10,482,474 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions EXP Minocycline inhibits the reaction [Morphine results in increased expression of PTGS1 mRNA] CTD PMID:18706994 NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Minocycline inhibits the reaction [Cisplatin results in increased expression of PTGS2 mRNA]; Minocycline inhibits the reaction [Morphine results in increased expression of PTGS2 protein]; Minocycline inhibits the reaction [T-2 Toxin results in increased expression of PTGS2 mRNA]; Minocycline inhibits the reaction [T-2 Toxin results in increased expression of PTGS2 protein] CTD PMID:36775139 PMID:37394652 PMID:37769865 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO Minocycline inhibits the reaction [Morphine results in increased expression of PYCARD protein] CTD PMID:37394652 NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:192,032,124...192,033,419 		JBrowse link
G Rbfox3 RNA binding fox-1 homolog 3 multiple interactions ISO Minocycline inhibits the reaction [Paraquat results in decreased expression of RBFOX3 protein]; Minocycline inhibits the reaction [Rotenone results in decreased expression of RBFOX3 protein] CTD PMID:33402167 PMID:38189626 NCBI chr10:104,218,940...104,655,863
Ensembl chr10:104,218,940...104,551,945 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects expression ISO Minocycline affects the expression of RELA protein CTD PMID:17898303 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 multiple interactions EXP Minocycline inhibits the reaction [Paclitaxel results in increased expression of RIPK3 protein] CTD PMID:38459698 NCBI chr15:33,253,071...33,262,025
Ensembl chr15:33,253,071...33,262,025 		JBrowse link
G RT1-CE16 RT1 class I, locus CE16 affects expression ISO Minocycline affects the expression of HLA-A mRNA CTD PMID:25811541 NCBI chr20:3,261,656...3,265,548 JBrowse link
G RT1-CE5 RT1 class I, locus CE5 affects expression ISO Minocycline affects the expression of HLA-F mRNA CTD PMID:25811541 NCBI chr20:3,407,880...3,484,130 JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Minocycline inhibits the reaction [SLC22A6 protein results in increased uptake of Anions] CTD PMID:11855680 NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO Minocycline inhibits the reaction [SLC22A7 protein results in increased uptake of Anions] CTD PMID:11855680 NCBI chr 9:22,044,672...22,052,051
Ensembl chr 9:22,045,435...22,051,681 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO Minocycline inhibits the reaction [Oxygen deficiency results in increased expression of SLC2A1 mRNA] CTD PMID:24292262 NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO Minocycline inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]; Minocycline inhibits the reaction [Paraquat results in decreased expression of SLC6A3 protein] CTD PMID:16839653 PMID:38189626 NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:31,537,990...31,578,962 		JBrowse link
G Snap25 synaptosome associated protein 25 multiple interactions EXP Minocycline inhibits the reaction [cypermethrin results in decreased expression of SNAP25 protein] CTD PMID:21561882 NCBI chr 3:144,494,579...144,576,449
Ensembl chr 3:144,494,595...144,576,448 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SOD2 protein] CTD PMID:23562983 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Stmn1 stathmin 1 multiple interactions EXP
ISO 		Minocycline inhibits the reaction [cypermethrin results in decreased expression of STMN1 protein]
Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STMN1 protein] 		CTD PMID:21561882 PMID:23562983 NCBI chr 5:151,964,308...151,970,843
Ensembl chr 5:151,964,351...151,970,842 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions 		EXP Minocycline results in increased expression of TGFB1 mRNA
Minocycline inhibits the reaction [Toluene results in decreased expression of TGFB1 mRNA] 		CTD PMID:32234516 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions ISO [Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2 protein] results in increased expression of BCL2 mRNA; [Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of BCL2 protein; [Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of XIAP mRNA; [Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of XIAP protein CTD PMID:20606027 NCBI chr13:100,691,540...100,793,227
Ensembl chr13:100,692,953...100,792,856 		JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO Minocycline inhibits the reaction [Paraquat results in decreased expression of TH protein] CTD PMID:38189626 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression 		EXP
ISO 		Minocycline inhibits the reaction [lead acetate results in increased secretion of TNF protein]; Minocycline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Minocycline inhibits the reaction [manganese chloride results in increased expression of TNF protein]; Minocycline inhibits the reaction [Paclitaxel results in increased expression of TNF protein]
minocycline inhibits the reaction [LPS increases expression of TNFa mRNA in hypothalamic microglia of alcohol fed neonates]
minocycline inhibits the reaction [ethanol increases expression of TNFa mRNA and protein in hypothalamic microglia]
Minocycline inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased secretion of TNF protein]; Minocycline inhibits the reaction [Cisplatin results in increased expression of TNF mRNA]; Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of TNF mRNA]; Minocycline inhibits the reaction [Dietary Fats results in increased expression of TNF protein]; Minocycline inhibits the reaction [lead acetate results in increased secretion of TNF protein]; Minocycline inhibits the reaction [Methamphetamine results in increased secretion of TNF protein]; Minocycline inhibits the reaction [Morphine results in increased expression of TNF protein]; Minocycline inhibits the reaction [Paraquat results in increased expression of TNF protein]; Minocycline inhibits the reaction [Rotenone results in increased expression of TNF mRNA]; Minocycline inhibits the reaction [T-2 Toxin results in increased expression of TNF mRNA]; Minocycline inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]
Minocycline results in decreased expression of TNF mRNA 		CTD
RGD		 PMID:14588118 PMID:15485488 PMID:18836210 PMID:19285099 PMID:21719015 More... RGD:598092506, RGD:598092506 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tp53 tumor protein p53 decreases expression EXP Minocycline results in decreased expression of TP53 protein CTD PMID:15172883 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Tpo thyroid peroxidase decreases activity EXP Minocycline results in decreased activity of TPO protein CTD PMID:26884060 NCBI chr 6:52,425,998...52,495,793
Ensembl chr 6:52,426,010...52,495,793 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 multiple interactions ISO Minocycline inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TREM2 mRNA] CTD PMID:35351628 NCBI chr 9:20,145,215...20,151,797
Ensembl chr 9:20,144,334...20,151,779 		JBrowse link
G Tuba1a tubulin, alpha 1A multiple interactions ISO Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TUBA1A protein] CTD PMID:23562983 NCBI chr 7:131,992,151...131,996,850
Ensembl chr 7:131,968,770...131,996,035 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Minocycline results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
G Vegfc vascular endothelial growth factor C multiple interactions ISO Minocycline inhibits the reaction [Oxygen deficiency results in increased expression of VEGFC mRNA] CTD PMID:24292262 NCBI chr16:44,445,293...44,560,887
Ensembl chr16:44,445,293...44,560,887 		JBrowse link
G Vegfd vascular endothelial growth factor D multiple interactions ISO Minocycline inhibits the reaction [Oxygen deficiency results in increased expression of VEGFD mRNA] CTD PMID:24292262 NCBI chr  X:33,704,582...33,740,305
Ensembl chr  X:33,706,055...33,740,167 		JBrowse link
G Vhl von Hippel-Lindau tumor suppressor multiple interactions ISO [[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] inhibits the reaction [Oxygen deficiency results in increased stability of HIF1A protein]; [[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] results in increased degradation of HIF1A protein; Minocycline promotes the reaction [HIF1A protein binds to VHL protein] CTD PMID:24292262 NCBI chr 4:148,328,099...148,334,992
Ensembl chr 4:148,328,079...148,334,991 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions EXP Minocycline inhibits the reaction [Paraquat results in increased expression of XBP1 protein] CTD PMID:22245251 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706 		JBrowse link
G Xiap X-linked inhibitor of apoptosis increases expression
multiple interactions 		EXP
ISO 		Minocycline results in increased expression of XIAP protein
[Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of XIAP mRNA; [Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of XIAP protein 		CTD PMID:14998631 PMID:20606027 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:125,737,971...125,803,978 		JBrowse link
Omadacycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
multiple interactions 		ISO ABCB1 protein results in increased transport of omadacycline
[zosuquidar trihydrochloride results in decreased activity of ABCB1 protein] which results in decreased transport of omadacycline 		CTD PMID:27499331 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 affects binding ISO omadacycline binds to CHRM2 protein CTD PMID:27324778 NCBI chr 4:65,981,136...66,116,128
Ensembl chr 4:65,981,006...66,126,464 		JBrowse link
oxytetracycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity ISO Oxytetracycline results in decreased activity of CAT protein CTD PMID:29248593 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Oxytetracycline results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO Oxytetracycline results in decreased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Oxytetracycline results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Oxytetracycline results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884 		JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO Oxytetracycline results in decreased activity of DIO1 protein CTD PMID:29228274 NCBI chr 5:127,303,089...127,319,784
Ensembl chr 5:127,303,083...127,319,771 		JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Oxytetracycline results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Oxytetracycline inhibits the reaction [SLC22A6 protein results in increased uptake of Anions] CTD PMID:11855680 NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO Oxytetracycline inhibits the reaction [SLC22A7 protein results in increased uptake of Anions] CTD PMID:11855680 NCBI chr 9:22,044,672...22,052,051
Ensembl chr 9:22,045,435...22,051,681 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Oxytetracycline results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
tetracycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadac arylacetamide deacetylase decreases expression ISO Tetracycline results in decreased expression of AADAC mRNA CTD PMID:24489787 NCBI chr 2:146,293,449...146,351,061
Ensembl chr 2:146,313,279...146,324,525 		JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO Tetracycline results in increased expression of ABCA1 mRNA CTD PMID:16917069 NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473 		JBrowse link
G Abca8 ATP binding cassette subfamily A member 8 increases expression ISO Tetracycline results in increased expression of ABCA8B mRNA CTD PMID:16917069 NCBI chr10:95,416,984...95,490,647
Ensembl chr10:95,416,205...95,490,452 		JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression EXP Tetracycline results in decreased expression of ABCB11 mRNA CTD PMID:17522070 PMID:19224547 PMID:27765674 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression EXP Tetracycline results in increased expression of ABCB1 mRNA CTD PMID:17522070 PMID:19224547 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression ISO
EXP 		Tetracycline results in decreased expression of ABCB4 mRNA CTD PMID:24489787 PMID:27765674 NCBI chr 4:26,106,895...26,164,440 JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression EXP Tetracycline results in decreased expression of ABCC2 mRNA CTD PMID:27765674 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Tetracycline results in increased expression of ABCC3 mRNA CTD PMID:17522070 PMID:27765674 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases transport
increases expression 		ISO
EXP 		ABCC4 protein results in increased transport of Tetracycline
Tetracycline results in increased expression of ABCC4 mRNA 		CTD PMID:17939016 PMID:27765674 NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375 		JBrowse link
G Abcd2 ATP binding cassette subfamily D member 2 decreases expression ISO Tetracycline results in decreased expression of ABCD2 mRNA CTD PMID:24489787 NCBI chr 7:124,142,597...124,191,202
Ensembl chr 7:124,142,595...124,191,202 		JBrowse link
G Abcd3 ATP binding cassette subfamily D member 3 increases expression
decreases expression 		ISO Tetracycline results in increased expression of ABCD3 mRNA
Tetracycline results in decreased expression of ABCD3 mRNA 		CTD PMID:16917069 PMID:24489787 NCBI chr 2:212,536,791...212,590,379
Ensembl chr 2:212,536,791...212,590,504 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 decreases expression ISO Tetracycline results in decreased expression of ABCG2 mRNA CTD PMID:24489787 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 decreases expression ISO
EXP 		Tetracycline results in decreased expression of ABCG5 mRNA CTD PMID:24489787 PMID:27765674 NCBI chr 6:15,717,936...15,743,376
Ensembl chr 6:15,717,936...15,743,376 		JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 decreases expression ISO Tetracycline results in decreased expression of ABCG8 mRNA CTD PMID:24489787 NCBI chr 6:15,698,448...15,717,730
Ensembl chr 6:15,698,448...15,717,730 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha decreases expression ISO Tetracycline results in decreased expression of ACACA mRNA CTD PMID:24489787 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888 		JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain multiple interactions
decreases expression 		ISO bicyclol inhibits the reaction [Tetracycline results in decreased expression of ACADL mRNA] CTD PMID:19427351 NCBI chr 9:75,783,689...75,822,077
Ensembl chr 9:75,783,689...75,822,164 		JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain decreases expression EXP Tetracycline results in decreased expression of ACADM mRNA CTD PMID:17522070 NCBI chr 2:245,518,693...245,542,864
Ensembl chr 2:245,518,693...245,542,864 		JBrowse link
G Acadsb acyl-CoA dehydrogenase, short/branched chain increases expression ISO Tetracycline results in increased expression of ACADSB mRNA CTD PMID:16917069 NCBI chr 1:195,619,088...195,660,564
Ensembl chr 1:195,619,038...195,660,561 		JBrowse link
G Acadvl acyl-CoA dehydrogenase, very long chain decreases expression ISO Tetracycline results in decreased expression of ACADVL mRNA CTD PMID:24489787 NCBI chr10:55,231,558...55,236,786
Ensembl chr10:55,231,440...55,236,750 		JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 decreases expression ISO Tetracycline results in decreased expression of ACAT1 mRNA CTD PMID:24489787 NCBI chr 8:62,876,003...62,905,080
Ensembl chr 8:62,876,003...62,905,042 		JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 increases expression
decreases expression 		ISO Tetracycline results in increased expression of ACAT2 mRNA
Tetracycline results in decreased expression of ACAT2 mRNA 		CTD PMID:16917069 PMID:24489787 NCBI chr 1:50,100,840...50,118,886
Ensembl chr 1:50,100,817...50,135,095 		JBrowse link
G Acbd5 acyl-CoA binding domain containing 5 increases expression ISO Tetracycline results in increased expression of ACBD5 mRNA CTD PMID:16917069 NCBI chr17:90,114,250...90,156,286
Ensembl chr17:90,114,375...90,156,286 		JBrowse link
G Ace2 angiotensin converting enzyme 2 increases expression ISO Tetracycline results in increased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:33,925,458...33,971,596 		JBrowse link
G Acly ATP citrate lyase decreases expression EXP Tetracycline results in decreased expression of ACLY mRNA CTD PMID:17522070 NCBI chr10:85,912,402...85,964,605
Ensembl chr10:85,912,402...85,963,631 		JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression
decreases expression 		ISO Tetracycline results in increased expression of ACOX1 mRNA
Tetracycline results in decreased expression of ACOX1 mRNA 		CTD PMID:16917069 PMID:24489787 NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,905,083...101,930,136 		JBrowse link
G Acox2 acyl-CoA oxidase 2 decreases expression EXP
ISO 		Tetracycline results in decreased expression of ACOX2 mRNA CTD PMID:19224547 PMID:24489787 NCBI chr15:19,090,820...19,122,392
Ensembl chr15:19,090,926...19,122,392 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases expression
decreases expression 		ISO
EXP 		Tetracycline results in increased expression of ACSL1 mRNA
Tetracycline results in decreased expression of ACSL1 mRNA 		CTD PMID:16917069 PMID:17522070 PMID:24489787 NCBI chr16:52,487,870...52,554,110
Ensembl chr16:52,487,870...52,554,023 		JBrowse link
G Acsm1 acyl-CoA synthetase medium-chain family member 1 decreases expression ISO Tetracycline results in decreased expression of ACSM1 mRNA CTD PMID:24489787 NCBI chr 1:183,417,052...183,451,897
Ensembl chr 1:183,416,009...183,454,217 		JBrowse link
G Acsm2 acyl-CoA synthetase medium-chain family member 2 increases expression ISO Tetracycline results in increased expression of ACSM2 mRNA CTD PMID:16917069 NCBI chr 1:183,347,705...183,386,453
Ensembl chr 1:183,347,705...183,386,453 		JBrowse link
G Acsm3 acyl-CoA synthetase medium-chain family member 3 decreases expression ISO Tetracycline results in decreased expression of ACSM3 mRNA CTD PMID:24489787 NCBI chr 1:183,564,652...183,591,328
Ensembl chr 1:183,564,635...183,591,437 		JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 decreases expression ISO Tetracycline results in decreased expression of ACSS2 mRNA CTD PMID:24489787 NCBI chr 3:164,464,124...164,507,607
Ensembl chr 3:164,464,055...164,519,830 		JBrowse link
G Adipor2 adiponectin receptor 2 increases expression ISO Tetracycline results in increased expression of ADIPOR2 mRNA CTD PMID:16917069 NCBI chr 4:154,195,440...154,261,141
Ensembl chr 4:154,172,567...154,231,666 		JBrowse link
G Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 increases expression ISO Tetracycline results in increased expression of AGPAT2 mRNA CTD PMID:16917069 NCBI chr 3:29,814,924...29,826,569
Ensembl chr 3:29,814,924...29,826,581 		JBrowse link
G Agpat4 1-acylglycerol-3-phosphate O-acyltransferase 4 decreases expression ISO Tetracycline results in decreased expression of AGPAT4 mRNA CTD PMID:16917069 NCBI chr 1:51,075,081...51,181,548
Ensembl chr 1:51,075,081...51,180,976 		JBrowse link
G Agt angiotensinogen decreases expression ISO Tetracycline results in decreased expression of AGT mRNA CTD PMID:24489787 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Ak3 adenylate kinase 3 decreases expression ISO Tetracycline results in decreased expression of AK3 mRNA CTD PMID:24489787 NCBI chr 1:236,151,012...236,178,689
Ensembl chr 1:236,151,012...236,178,183 		JBrowse link
G Ak4 adenylate kinase 4 increases expression EXP Tetracycline results in increased expression of AK4 protein CTD PMID:16538043 NCBI chr 5:121,154,565...121,214,403
Ensembl chr 5:121,154,572...121,214,401 		JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 increases expression ISO Tetracycline results in increased expression of AKR1D1 mRNA CTD PMID:16917069 NCBI chr 4:67,121,288...67,154,543
Ensembl chr 4:67,120,024...67,154,540 		JBrowse link
G Alas1 5'-aminolevulinate synthase 1 decreases expression ISO Tetracycline results in decreased expression of ALAS1 mRNA CTD PMID:24489787 NCBI chr 8:115,755,238...115,768,642
Ensembl chr 8:115,755,238...115,768,642 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression ISO Tetracycline results in decreased expression of ALDH1A1 mRNA CTD PMID:24489787 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500 		JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 decreases expression EXP Tetracycline results in decreased expression of ALDH3A2 mRNA CTD PMID:17522070 NCBI chr10:46,427,789...46,448,449
Ensembl chr10:46,407,993...46,448,648 		JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression EXP Tetracycline results in increased expression of ALDOA mRNA CTD PMID:17522070 NCBI chr 1:190,832,820...190,838,021
Ensembl chr 1:190,832,820...190,838,211 		JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein decreases expression ISO Tetracycline results in decreased expression of ALOX5AP mRNA CTD PMID:16917069 NCBI chr12:10,785,254...10,809,295
Ensembl chr12:10,785,257...10,817,038 		JBrowse link
G Amacr alpha-methylacyl-CoA racemase decreases expression ISO Tetracycline results in decreased expression of AMACR mRNA CTD PMID:24489787 NCBI chr 2:61,673,291...61,685,381
Ensembl chr 2:61,670,475...61,685,379 		JBrowse link
G Angptl3 angiopoietin-like 3 decreases expression ISO Tetracycline results in decreased expression of ANGPTL3 mRNA CTD PMID:24489787 NCBI chr 5:118,818,494...118,825,531
Ensembl chr 5:118,818,499...118,826,444 		JBrowse link
G Aoah acyloxyacyl hydrolase increases expression ISO Tetracycline results in increased expression of AOAH mRNA CTD PMID:16917069 NCBI chr17:48,503,812...48,745,161
Ensembl chr17:48,503,812...48,745,146 		JBrowse link
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression ISO Tetracycline results in decreased expression of AP1S1 mRNA CTD PMID:17175557 NCBI chr12:25,261,958...25,272,483
Ensembl chr12:25,262,036...25,272,483 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases expression EXP Tetracycline results in increased expression of APEX1 mRNA CTD PMID:17522070 NCBI chr15:26,618,146...26,620,330
Ensembl chr15:26,618,224...26,620,329 		JBrowse link
G Apob apolipoprotein B decreases expression EXP Tetracycline results in decreased expression of APOB mRNA CTD PMID:19224547 NCBI chr 6:36,563,704...36,603,300
Ensembl chr 6:36,563,704...36,611,814 		JBrowse link
G Apoc1 apolipoprotein C1 decreases expression ISO Tetracycline results in decreased expression of APOC1 mRNA CTD PMID:16917069 NCBI chr 1:88,475,018...88,479,052
Ensembl chr 1:88,474,663...88,478,155 		JBrowse link
G Apoc2 apolipoprotein C2 decreases expression ISO Tetracycline results in decreased expression of APOC2 mRNA CTD PMID:16917069 PMID:24489787 NCBI chr 1:88,457,397...88,462,365
Ensembl chr 1:88,457,396...88,463,438 		JBrowse link
G Apoc3 apolipoprotein C3 decreases expression ISO Tetracycline results in decreased expression of APOC3 mRNA CTD PMID:16917069 NCBI chr 8:55,428,172...55,430,352
Ensembl chr 8:55,428,024...55,458,679 		JBrowse link
G Apof apolipoprotein F decreases expression ISO Tetracycline results in decreased expression of APOF mRNA CTD PMID:24489787 NCBI chr 7:1,285,222...1,286,659
Ensembl chr 7:1,285,222...1,286,659 		JBrowse link
G Ar androgen receptor decreases expression ISO Tetracycline results in decreased expression of AR mRNA CTD PMID:16917069 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator increases expression ISO Tetracycline results in increased expression of ARNT mRNA CTD PMID:16917069 NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:185,680,683...185,745,546 		JBrowse link
G Arsa arylsulfatase A decreases expression ISO Tetracycline results in decreased expression of ARSA mRNA CTD PMID:16917069 NCBI chr 7:122,422,971...122,426,971
Ensembl chr 7:122,422,982...122,428,401 		JBrowse link
G Asgr2 asialoglycoprotein receptor 2 decreases expression ISO Tetracycline results in decreased expression of ASGR2 mRNA CTD PMID:24489787 NCBI chr10:55,320,082...55,333,294
Ensembl chr10:55,320,091...55,333,263 		JBrowse link
G Asl argininosuccinate lyase increases expression EXP Tetracycline results in increased expression of ASL mRNA CTD PMID:17522070 NCBI chr12:32,295,779...32,313,257
Ensembl chr12:32,295,633...32,317,261 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Tetracycline results in increased expression of ASNS mRNA CTD PMID:17175557 NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050 		JBrowse link
G Atp11a ATPase phospholipid transporting 11A decreases expression ISO Tetracycline results in decreased expression of ATP11A mRNA CTD PMID:16917069 NCBI chr16:83,359,884...83,469,807
Ensembl chr16:83,359,884...83,469,767 		JBrowse link
G Auh AU RNA binding methylglutaconyl-CoA hydratase increases expression ISO Tetracycline results in increased expression of AUH mRNA CTD PMID:16917069 NCBI chr17:12,481,396...12,576,748
Ensembl chr17:12,481,416...12,602,587 		JBrowse link
G Bbox1 gamma-butyrobetaine hydroxylase 1 decreases expression ISO Tetracycline results in decreased expression of BBOX1 mRNA CTD PMID:24489787 NCBI chr 3:117,277,226...117,326,383
Ensembl chr 3:117,277,226...117,326,064 		JBrowse link
G Bckdha branched chain keto acid dehydrogenase E1 subunit alpha increases expression EXP Tetracycline results in increased expression of BCKDHA protein CTD PMID:16538043 NCBI chr 1:90,266,731...90,295,521
Ensembl chr 1:90,261,629...90,295,749 		JBrowse link
G Bdh1 3-hydroxybutyrate dehydrogenase 1 decreases expression ISO Tetracycline results in decreased expression of BDH1 mRNA CTD PMID:24489787 NCBI chr11:82,806,125...82,848,133
Ensembl chr11:82,807,503...82,842,636 		JBrowse link
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin decreases expression ISO Tetracycline results in decreased expression of BSCL2 mRNA CTD PMID:24489787 NCBI chr 1:215,160,764...215,172,540
Ensembl chr 1:215,160,957...215,172,536 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression EXP Tetracycline results in increased expression of BTG2 mRNA CTD PMID:17522070 NCBI chr13:48,083,931...48,087,690
Ensembl chr13:48,083,931...48,087,690 		JBrowse link
G Ca3 carbonic anhydrase 3 increases expression EXP Tetracycline results in increased expression of CAR3 protein CTD PMID:16538043 NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:88,491,670...88,500,524 		JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 increases expression ISO Tetracycline results in increased expression of CACNA2D1 mRNA CTD PMID:16917069 NCBI chr 4:19,902,324...20,330,287
Ensembl chr 4:19,905,764...20,330,147 		JBrowse link
G Calu calumenin increases expression EXP Tetracycline results in increased expression of CALU mRNA CTD PMID:17522070 NCBI chr 4:58,914,456...58,941,957
Ensembl chr 4:58,914,421...58,941,956 		JBrowse link
G Casp3 caspase 3 decreases expression ISO Tetracycline results in decreased expression of CASP3 mRNA CTD PMID:24489787 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cat catalase increases expression
decreases expression 		ISO
EXP 		Tetracycline results in increased expression of CAT mRNA
Tetracycline results in decreased expression of CAT mRNA 		CTD PMID:16917069 PMID:17522070 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Cbfa2t2 CBFA2/RUNX1 partner transcriptional co-repressor 2 increases expression ISO Tetracycline results in increased expression of CBFA2T2 mRNA CTD PMID:16917069 NCBI chr 3:163,397,160...163,503,409
Ensembl chr 3:163,397,185...163,503,407 		JBrowse link
G Cbs cystathionine beta synthase decreases expression ISO Tetracycline results in decreased expression of CBS mRNA CTD PMID:24489787 NCBI chr20:9,709,394...9,733,925
Ensembl chr20:9,709,395...9,734,066 		JBrowse link
G Ccn2 cellular communication network factor 2 increases expression ISO Tetracycline results in increased expression of CCN2 mRNA CTD PMID:16917069 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976 		JBrowse link
G Ccnb3 cyclin B3 increases expression ISO Tetracycline results in increased expression of CCNB3 mRNA CTD PMID:16917069 NCBI chr  X:18,149,915...18,214,801
Ensembl chr  X:18,149,915...18,214,801 		JBrowse link
G Ccnd1 cyclin D1 decreases expression EXP Tetracycline results in decreased expression of CCND1 mRNA CTD PMID:19224547 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Ccng1 cyclin G1 increases expression EXP Tetracycline results in increased expression of CCNG1 mRNA CTD PMID:17522070 NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,677,885...25,683,766 		JBrowse link
G Cd36 CD36 molecule multiple interactions
increases expression 		ISO [Tetracycline results in increased expression of CD36 protein] which results in increased uptake of Fatty Acids
Tetracycline results in increased expression of CD36 mRNA; Tetracycline results in increased expression of CD36 protein 		CTD PMID:25745068 NCBI chr 4:18,209,088...18,302,142 JBrowse link
G Cers2 ceramide synthase 2 increases expression ISO Tetracycline results in increased expression of CERS2 mRNA CTD PMID:16917069 NCBI chr 2:185,579,511...185,587,789
Ensembl chr 2:185,579,119...185,588,839 		JBrowse link
G Cers5 ceramide synthase 5 increases expression ISO Tetracycline results in increased expression of CERS5 mRNA CTD PMID:16917069 NCBI chr 7:132,738,834...132,776,920
Ensembl chr 7:132,738,834...132,776,786 		JBrowse link
G Chka choline kinase alpha increases expression ISO Tetracycline results in increased expression of CHKA mRNA CTD PMID:16917069 NCBI chr 1:210,506,069...210,554,753
Ensembl chr 1:210,506,056...210,554,752 		JBrowse link
G Cideb cell death-inducing DFFA-like effector b decreases expression ISO Tetracycline results in decreased expression of CIDEB mRNA CTD PMID:24489787 NCBI chr15:33,222,135...33,226,407
Ensembl chr15:33,221,824...33,226,688 		JBrowse link
G Cldn10 claudin 10 decreases expression ISO Tetracycline results in decreased expression of CLDN10 mRNA CTD PMID:28882639 NCBI chr15:102,269,858...102,361,589
Ensembl chr15:102,269,858...102,361,589 		JBrowse link
G Cldn11 claudin 11 decreases expression ISO Tetracycline results in decreased expression of CLDN11 mRNA CTD PMID:28882639 NCBI chr 2:114,136,234...114,149,539
Ensembl chr 2:114,136,234...114,149,539 		JBrowse link
G Cldn15 claudin 15 decreases expression ISO Tetracycline results in decreased expression of CLDN15 mRNA CTD PMID:28882639 NCBI chr12:25,334,849...25,345,104
Ensembl chr12:25,334,849...25,343,477 		JBrowse link
G Cldn2 claudin 2 decreases expression ISO Tetracycline results in decreased expression of CLDN2 mRNA CTD PMID:28882639 NCBI chr  X:108,248,383...108,258,847
Ensembl chr  X:108,237,676...108,262,377 		JBrowse link
G Cldn6 claudin 6 decreases expression ISO Tetracycline results in decreased expression of CLDN6 mRNA CTD PMID:28882639 NCBI chr10:13,213,837...13,218,578
Ensembl chr10:13,213,956...13,218,581 		JBrowse link
G Cldn8 claudin 8 decreases expression ISO Tetracycline results in decreased expression of CLDN8 mRNA CTD PMID:28882639 NCBI chr11:41,362,081...41,364,330 JBrowse link
G Clu clusterin increases expression EXP Tetracycline results in increased expression of CLU mRNA CTD PMID:17522070 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860 		JBrowse link
G Cox19 cytochrome c oxidase assembly factor COX19 decreases expression ISO Tetracycline results in decreased expression of COX19 mRNA CTD PMID:24489787 NCBI chr12:20,417,389...20,426,868
Ensembl chr12:20,417,341...20,426,868 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression EXP
ISO 		Tetracycline results in decreased expression of CPT1A mRNA CTD PMID:19224547 PMID:24489787 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326 		JBrowse link
G Crat carnitine O-acetyltransferase decreases expression ISO Tetracycline results in decreased expression of CRAT mRNA CTD PMID:16917069 NCBI chr 3:34,073,504...34,087,099
Ensembl chr 3:34,073,506...34,087,099 		JBrowse link
G Crot carnitine O-octanoyltransferase increases expression
decreases expression 		ISO Tetracycline results in increased expression of CROT mRNA
Tetracycline results in decreased expression of CROT mRNA 		CTD PMID:16917069 PMID:24489787 NCBI chr 4:26,031,729...26,088,057
Ensembl chr 4:26,052,516...26,088,064 		JBrowse link
G Cryab crystallin, alpha B decreases expression ISO Tetracycline results in decreased expression of CRYAB mRNA CTD PMID:24489787 NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:59,989,814...59,995,528 		JBrowse link
G Csf1 colony stimulating factor 1 increases expression ISO Tetracycline results in increased expression of CSF1 mRNA CTD PMID:16917069 NCBI chr 2:198,065,400...198,084,774
Ensembl chr 2:198,065,405...198,084,468 		JBrowse link
G Ctsl cathepsin L increases expression EXP Tetracycline results in increased expression of CTSL mRNA CTD PMID:17522070 NCBI chr17:770,104...776,266
Ensembl chr17:770,093...777,113 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO Tetracycline results in decreased expression of CXCL12 mRNA CTD PMID:24489787 NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:152,060,780...152,073,627 		JBrowse link
G Cyb5a cytochrome b5 type A decreases expression ISO Tetracycline results in decreased expression of CYB5A mRNA CTD PMID:16917069 NCBI chr18:80,487,923...80,520,544
Ensembl chr18:14,453,966...14,455,094
Ensembl chr18:14,453,966...14,455,094 		JBrowse link
G Cyb5b cytochrome b5 type B increases expression ISO Tetracycline results in increased expression of CYB5B mRNA CTD PMID:16917069 NCBI chr19:51,972,611...52,006,477
Ensembl chr19:51,972,547...52,026,980 		JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 decreases expression EXP Tetracycline results in decreased expression of CYB5R3 mRNA CTD PMID:17522070 NCBI chr 7:116,186,729...116,204,290
Ensembl chr 7:116,186,729...116,204,306 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO Tetracycline results in decreased expression of CYP17A1 mRNA CTD PMID:16917069 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression EXP Tetracycline results in decreased expression of CYP1A1 mRNA CTD PMID:19224547 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 decreases expression ISO Tetracycline results in decreased expression of CYP26A1 mRNA CTD PMID:16917069 NCBI chr 1:244,883,822...244,887,657
Ensembl chr 1:244,883,752...244,887,657 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression ISO Tetracycline results in decreased expression of CYP27A1 mRNA CTD PMID:24489787 NCBI chr 9:83,712,402...83,743,222
Ensembl chr 9:83,713,293...83,743,215 		JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 decreases expression ISO Tetracycline results in decreased expression of CYP2A4 mRNA CTD PMID:16917069 NCBI chr 1:91,299,584...91,307,650
Ensembl chr 1:91,299,561...91,307,649 		JBrowse link
G Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 decreases expression EXP Tetracycline results in decreased expression of CYP2D3 mRNA CTD PMID:17522070 NCBI chr 7:115,797,785...115,802,142
Ensembl chr 7:115,797,789...115,802,158 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases expression 		ISO bicyclol inhibits the reaction [Tetracycline results in decreased expression of CYP2E1 mRNA] CTD PMID:19427351 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 increases expression ISO Tetracycline results in increased expression of CYP2J9 mRNA CTD PMID:16917069 NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:116,295,694...116,323,042 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases expression
increases expression
multiple interactions 		EXP
ISO 		Tetracycline results in decreased expression of CYP3A4 mRNA
Tetracycline results in increased expression of CYP3A4 mRNA
Tetracycline results in increased expression of and results in increased activity of CYP3A4 protein 		CTD PMID:18505790 PMID:19224547 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 decreases expression ISO Tetracycline results in decreased expression of CYP46A1 mRNA CTD PMID:16917069 NCBI chr 6:133,011,948...133,039,167
Ensembl chr 6:133,011,989...133,041,971 		JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression
decreases expression 		EXP Tetracycline results in increased expression of CYP4A1 mRNA
Tetracycline results in decreased expression of CYP4A22 mRNA 		CTD PMID:12883083 PMID:19224547 NCBI chr 5:134,360,096...134,374,233
Ensembl chr 5:134,360,111...134,374,231 		JBrowse link
G Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 increases expression ISO Tetracycline results in increased expression of CYP4F14 mRNA CTD PMID:16917069 NCBI chr 7:12,661,357...12,672,952
Ensembl chr 7:12,661,359...12,672,612 		JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 increases expression ISO Tetracycline results in increased expression of CYP4F18 mRNA CTD PMID:16917069 NCBI chr16:17,797,558...17,838,958
Ensembl chr16:17,740,001...17,838,958 		JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression ISO Tetracycline results in increased expression of CYP51 mRNA CTD PMID:16917069 NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,991,613...31,010,450 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression
decreases expression 		ISO
EXP 		Tetracycline results in increased expression of CYP7A1 mRNA
Tetracycline results in decreased expression of CYP7A1 mRNA 		CTD PMID:16917069 PMID:19224547 NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202 		JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases expression ISO Tetracycline results in decreased expression of CYP7B1 mRNA CTD PMID:24489787 NCBI chr 2:102,419,011...102,586,047
Ensembl chr 2:102,419,011...102,451,804 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 increases expression
decreases expression 		ISO Tetracycline results in increased expression of CYP8B1 mRNA
Tetracycline results in decreased expression of CYP8B1 mRNA 		CTD PMID:16917069 PMID:24489787 NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:130,442,503...130,457,689 		JBrowse link
G Dbi diazepam binding inhibitor decreases expression ISO Tetracycline results in decreased expression of DBI mRNA CTD PMID:16917069 NCBI chr13:33,794,231...33,802,632
Ensembl chr13:33,759,845...33,821,450 		JBrowse link
G Ddc dopa decarboxylase decreases expression ISO Tetracycline results in decreased expression of DDC mRNA CTD PMID:24489787 NCBI chr14:90,592,304...90,682,830
Ensembl chr14:90,592,304...90,682,806 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP Tetracycline results in increased expression of DDIT3 mRNA CTD PMID:12883083 PMID:17522070 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Depp1 DEPP autophagy regulator 1 increases expression ISO Tetracycline results in increased expression of DEPP1 mRNA CTD PMID:17175557 NCBI chr 4:151,583,105...151,585,455
Ensembl chr 4:151,581,502...151,586,233 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 increases expression
multiple interactions 		ISO Tetracycline results in increased expression of DGAT2 protein
Tetracycline results in increased expression of DGAT2 mRNA; Tetracycline results in increased expression of DGAT2 protein
Tetracycline promotes the reaction [DGAT2 protein results in increased chemical synthesis of Triglycerides] 		CTD PMID:25745068 NCBI chr 1:162,866,237...162,896,655
Ensembl chr 1:162,866,237...162,896,566 		JBrowse link
G Dgka diacylglycerol kinase, alpha decreases expression ISO Tetracycline results in decreased expression of DGKA mRNA CTD PMID:16917069 NCBI chr 7:1,733,247...1,761,181
Ensembl chr 7:1,733,248...1,759,569 		JBrowse link
G Dhx29 DExH-box helicase 29 increases expression ISO Tetracycline results in increased expression of DHX29 mRNA CTD PMID:16917069 NCBI chr 2:46,293,901...46,344,652
Ensembl chr 2:46,293,677...46,344,948 		JBrowse link
G Dnajb8 DnaJ heat shock protein family (Hsp40) member B8 increases expression ISO Tetracycline results in increased expression of DNAJB8 mRNA CTD PMID:16917069 NCBI chr 4:122,239,209...122,242,277
Ensembl chr 4:122,227,595...122,247,526 		JBrowse link
G Dpm1 dolichyl-phosphate mannosyltransferase subunit 1, catalytic decreases expression ISO Tetracycline results in decreased expression of DPM1 mRNA CTD PMID:16917069 NCBI chr 3:177,338,855...177,358,398
Ensembl chr 3:177,338,855...177,358,412 		JBrowse link
G Eci1 enoyl-CoA delta isomerase 1 decreases expression ISO Tetracycline results in decreased expression of ECI1 mRNA CTD PMID:16917069 NCBI chr10:13,961,250...13,974,595
Ensembl chr10:13,961,218...13,974,773 		JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO Tetracycline results in decreased expression of EGFR mRNA CTD PMID:24489787 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase decreases expression ISO Tetracycline results in decreased expression of EHHADH mRNA CTD PMID:27089845 NCBI chr11:92,746,409...92,779,647
Ensembl chr11:92,746,420...92,779,662 		JBrowse link
G Elovl2 ELOVL fatty acid elongase 2 decreases expression ISO Tetracycline results in decreased expression of ELOVL2 mRNA CTD PMID:24489787 NCBI chr17:23,750,350...23,790,601
Ensembl chr17:23,750,350...23,790,601 		JBrowse link
G Elovl3 ELOVL fatty acid elongase 3 increases expression ISO Tetracycline results in increased expression of ELOVL3 mRNA CTD PMID:16917069 NCBI chr 1:254,938,731...254,942,559
Ensembl chr 1:254,938,731...254,942,559 		JBrowse link
G Elovl5 ELOVL fatty acid elongase 5 increases expression ISO Tetracycline results in increased expression of ELOVL5 mRNA CTD PMID:16917069 NCBI chr 8:87,671,164...87,737,618
Ensembl chr 8:87,671,159...87,737,616 		JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 decreases expression
increases expression 		EXP
ISO 		Tetracycline results in decreased expression of ELOVL6 mRNA
Tetracycline results in increased expression of ELOVL6 mRNA 		CTD PMID:16917069 PMID:19224547 NCBI chr 2:220,738,095...220,845,528
Ensembl chr 2:220,738,064...220,845,549 		JBrowse link
G Endog endonuclease G decreases expression ISO Tetracycline results in decreased expression of ENDOG mRNA CTD PMID:24489787 NCBI chr 3:33,846,935...33,849,531
Ensembl chr 3:33,846,885...33,849,573 		JBrowse link
G Ephx1 epoxide hydrolase 1 decreases expression ISO Tetracycline results in decreased expression of EPHX1 mRNA CTD PMID:24489787 NCBI chr13:95,246,079...95,275,852
Ensembl chr13:95,246,080...95,321,981 		JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression ISO Tetracycline results in decreased expression of EPHX2 mRNA CTD PMID:24489787 NCBI chr15:44,465,447...44,503,157
Ensembl chr15:44,465,448...44,503,160 		JBrowse link
G Ergic2 ERGIC and golgi 2 increases expression ISO Tetracycline results in increased expression of ERGIC2 mRNA CTD PMID:16917069 NCBI chr 4:182,822,225...182,858,392
Ensembl chr 4:182,822,225...182,854,490 		JBrowse link
G Etfdh electron transfer flavoprotein dehydrogenase decreases expression ISO Tetracycline results in decreased expression of ETFDH mRNA CTD PMID:24489787 NCBI chr 2:167,038,707...167,060,758
Ensembl chr 2:167,025,823...167,060,770 		JBrowse link
G Exosc10 exosome component 10 increases expression ISO Tetracycline results in increased expression of EXOSC10 mRNA CTD PMID:16917069 NCBI chr 5:164,278,414...164,302,067
Ensembl chr 5:164,278,440...164,302,067 		JBrowse link
G Exosc9 exosome component 9 increases expression ISO Tetracycline results in increased expression of EXOSC9 mRNA CTD PMID:16917069 NCBI chr 2:121,344,154...121,355,110
Ensembl chr 2:121,344,175...121,374,232 		JBrowse link
G F10 coagulation factor X decreases expression ISO Tetracycline results in decreased expression of F10 mRNA CTD PMID:24489787 NCBI chr16:83,170,973...83,190,280
Ensembl chr16:83,170,977...83,190,280 		JBrowse link
G Faah fatty acid amide hydrolase increases expression ISO Tetracycline results in increased expression of FAAH mRNA CTD PMID:16917069 NCBI chr 5:134,716,545...134,735,396
Ensembl chr 5:134,716,545...134,735,396 		JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression EXP
ISO 		Tetracycline results in decreased expression of FABP1 mRNA CTD PMID:16917069 PMID:17522070 PMID:19224547 PMID:24489787 NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:104,744,309...104,753,113 		JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression ISO Tetracycline results in decreased expression of FABP4 mRNA CTD PMID:16917069 NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972 		JBrowse link
G Fabp7 fatty acid binding protein 7 decreases expression ISO Tetracycline results in decreased expression of FABP7 mRNA CTD PMID:16917069 NCBI chr20:37,667,125...37,673,299
Ensembl chr20:37,669,601...37,675,907 		JBrowse link
G Fads1 fatty acid desaturase 1 decreases expression EXP Tetracycline results in decreased expression of FADS1 mRNA CTD PMID:17522070 NCBI chr 1:216,252,605...216,267,618
Ensembl chr 1:216,252,602...216,267,615 		JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO Tetracycline results in decreased expression of FAS mRNA CTD PMID:24489787 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104 		JBrowse link
G Fasn fatty acid synthase decreases expression EXP Tetracycline results in decreased expression of FASN mRNA CTD PMID:17522070 PMID:19224547 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 decreases expression ISO Tetracycline results in decreased expression of FDFT1 mRNA CTD PMID:24489787 NCBI chr15:41,588,114...41,616,168
Ensembl chr15:41,588,117...41,616,168 		JBrowse link
G Fdx1 ferredoxin 1 decreases expression ISO Tetracycline results in decreased expression of FDX1 mRNA CTD PMID:16917069 NCBI chr 8:61,164,839...61,183,645
Ensembl chr 8:61,164,839...61,183,583 		JBrowse link
G Fezf2 Fez family zinc finger 2 increases expression ISO Tetracycline results in increased expression of FEZF2 mRNA CTD PMID:16917069 NCBI chr15:15,199,045...15,207,982
Ensembl chr15:15,204,193...15,207,982 		JBrowse link
G Fga fibrinogen alpha chain increases expression EXP Tetracycline results in increased expression of FGA mRNA CTD PMID:17522070 NCBI chr 2:170,672,169...170,679,572
Ensembl chr 2:170,672,012...170,679,577 		JBrowse link
G Fgb fibrinogen beta chain increases expression EXP Tetracycline results in increased expression of FGB mRNA CTD PMID:17522070 NCBI chr 2:170,693,966...170,700,875
Ensembl chr 2:170,692,965...170,705,434 		JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 decreases expression EXP Tetracycline results in decreased expression of FMO1 mRNA CTD PMID:17522070 NCBI chr13:77,715,405...77,747,666
Ensembl chr13:77,715,402...77,747,874 		JBrowse link
G Fndc4 fibronectin type III domain containing 4 increases expression ISO Tetracycline results in increased expression of FNDC4 mRNA CTD PMID:17175557 NCBI chr 6:30,797,102...30,800,782
Ensembl chr 6:30,796,871...30,800,769 		JBrowse link
G Foxa1 forkhead box A1 decreases expression EXP Tetracycline results in decreased expression of FOXA1 mRNA CTD PMID:24469900 NCBI chr 6:80,838,380...80,871,195
Ensembl chr 6:80,800,960...80,871,191 		JBrowse link
G Fxyd7 FXYD domain-containing ion transport regulator 7 increases expression ISO Tetracycline results in increased expression of FXYD7 mRNA CTD PMID:16917069 NCBI chr 1:95,405,071...95,414,407
Ensembl chr 1:95,405,225...95,414,345 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO Tetracycline results in decreased expression of G6PC1 mRNA CTD PMID:24489787 NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Tetracycline results in increased expression of GADD45A mRNA CTD PMID:17522070 PMID:19224547 NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807 		JBrowse link
G Gata2 GATA binding protein 2 increases expression ISO Tetracycline results in increased expression of GATA2 mRNA CTD PMID:16917069 NCBI chr 4:122,211,501...122,225,058
Ensembl chr 4:122,211,829...122,225,055 		JBrowse link
G Gba2 glucosylceramidase beta 2 increases expression ISO Tetracycline results in increased expression of GBA2 mRNA CTD PMID:16917069 NCBI chr 5:62,618,176...62,630,160
Ensembl chr 5:62,618,177...62,630,308 		JBrowse link
G Gde1 glycerophosphodiester phosphodiesterase 1 decreases expression ISO Tetracycline results in decreased expression of GDE1 mRNA CTD PMID:16917069 NCBI chr 1:182,451,182...182,466,569
Ensembl chr 1:182,451,184...182,466,772 		JBrowse link
G Gdpd1 glycerophosphodiester phosphodiesterase domain containing 1 decreases expression ISO Tetracycline results in decreased expression of GDPD1 mRNA CTD PMID:16917069 NCBI chr10:72,318,716...72,381,143
Ensembl chr10:72,337,778...72,381,120 		JBrowse link
G Gga1 golgi associated, gamma adaptin ear containing, ARF binding protein 1 increases expression ISO Tetracycline results in increased expression of GGA1 mRNA CTD PMID:16917069 NCBI chr 7:112,316,530...112,332,249
Ensembl chr 7:112,315,449...112,332,249 		JBrowse link
G Gja8 gap junction protein, alpha 8 decreases expression ISO Tetracycline results in decreased expression of GJA8 mRNA CTD PMID:28882639 NCBI chr 2:187,179,668...187,181,284
Ensembl chr 2:187,175,507...187,186,167 		JBrowse link
G Gjd2 gap junction protein, delta 2 decreases expression ISO Tetracycline results in decreased expression of GJD2 mRNA CTD PMID:28882639 NCBI chr 3:121,226,372...121,229,367
Ensembl chr 3:121,226,368...121,230,603 		JBrowse link
G Glud1 glutamate dehydrogenase 1 increases expression EXP Tetracycline results in increased expression of GLUD1 protein CTD PMID:16538043 NCBI chr16:9,646,569...9,680,215
Ensembl chr16:9,646,509...9,680,210 		JBrowse link
G Glyat glycine-N-acyltransferase decreases expression ISO Tetracycline results in decreased expression of GLYAT mRNA CTD PMID:24489787 NCBI chr 1:219,128,798...219,149,615
Ensembl chr 1:219,128,811...219,150,774 		JBrowse link
G Gmpr2 guanosine monophosphate reductase 2 increases expression ISO Tetracycline results in increased expression of GMPR2 mRNA CTD PMID:16917069 NCBI chr15:33,135,455...33,144,923
Ensembl chr15:33,135,682...33,144,899 		JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 decreases expression ISO Tetracycline results in decreased expression of GPD1 mRNA CTD PMID:24489787 NCBI chr 7:132,722,982...132,730,373
Ensembl chr 7:132,721,915...132,730,368 		JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 increases expression ISO Tetracycline results in increased expression of GPD2 mRNA CTD PMID:16917069 NCBI chr 3:62,209,432...62,346,590
Ensembl chr 3:62,210,814...62,346,593 		JBrowse link
G Gpr151 G protein-coupled receptor 151 increases expression ISO Tetracycline results in increased expression of GPR151 mRNA CTD PMID:16917069 NCBI chr18:34,819,878...34,821,272
Ensembl chr18:34,819,878...34,821,272 		JBrowse link
G Gpt2 glutamic--pyruvic transaminase 2 decreases expression ISO Tetracycline results in decreased expression of GPT2 mRNA CTD PMID:24489787 NCBI chr19:37,700,023...37,734,551
Ensembl chr19:37,691,901...37,733,917 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression EXP Tetracycline results in decreased expression of GPX1 mRNA CTD PMID:17522070 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581 		JBrowse link
G Gpx3 glutathione peroxidase 3 decreases expression ISO Tetracycline results in decreased expression of GPX3 mRNA CTD PMID:16917069 NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,529,448...39,537,405 		JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression ISO Tetracycline results in decreased expression of GPX4 mRNA CTD PMID:16917069 NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases expression EXP Tetracycline results in decreased expression of GSTA2 mRNA CTD PMID:19224547 NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:88,064,616...88,077,092 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases activity
decreases expression 		ISO
EXP 		Tetracycline results in decreased activity of GSTM3 protein
Tetracycline results in decreased expression of GSTM3 mRNA 		CTD PMID:11807801 PMID:17522070 NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:198,219,647...198,222,731 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
increases expression
decreases activity 		ISO
EXP 		Tetracycline inhibits the reaction [GSTP1 protein affects the metabolism of and results in decreased activity of Ethacrynic Acid]
Tetracycline results in increased expression of GSTP2 mRNA
Tetracycline results in decreased activity of GSTP1 protein 		CTD PMID:11807801 PMID:19224547 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
G Gys2 glycogen synthase 2 decreases expression EXP Tetracycline results in decreased expression of GYS2 mRNA CTD PMID:19224547 NCBI chr 4:177,096,063...177,137,236
Ensembl chr 4:177,096,063...177,137,236 		JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase decreases expression ISO Tetracycline results in decreased expression of HADH mRNA CTD PMID:24489787 NCBI chr 2:222,462,049...222,504,446
Ensembl chr 2:222,462,049...222,504,446 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha increases expression
decreases expression 		ISO Tetracycline results in increased expression of HADHA mRNA
Tetracycline results in decreased expression of HADHA mRNA 		CTD PMID:16917069 PMID:24489787 NCBI chr 6:31,907,801...31,947,434
Ensembl chr 6:31,907,291...31,947,698 		JBrowse link
G Hexb hexosaminidase subunit beta increases expression ISO Tetracycline results in increased expression of HEXB mRNA CTD PMID:16917069 NCBI chr 2:30,218,608...30,238,771
Ensembl chr 2:30,218,608...30,238,771 		JBrowse link
G Hhex hematopoietically expressed homeobox decreases expression EXP Tetracycline results in decreased expression of HHEX mRNA CTD PMID:24469900 NCBI chr 1:244,602,945...244,608,532
Ensembl chr 1:244,602,825...244,608,604 		JBrowse link
G Hibadh 3-hydroxyisobutyrate dehydrogenase decreases expression EXP Tetracycline results in decreased expression of HIBADH mRNA CTD PMID:17522070 NCBI chr 4:82,979,759...83,077,819
Ensembl chr 4:82,979,765...83,111,242 		JBrowse link
G Hjv hemojuvelin BMP co-receptor decreases expression ISO Tetracycline results in decreased expression of HJV mRNA CTD PMID:24489787 NCBI chr 2:186,754,801...186,758,708
Ensembl chr 2:186,754,811...186,758,867 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression EXP Tetracycline results in decreased expression of HMGCR mRNA CTD PMID:19224547 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Tetracycline results in increased expression of HMGCS1 mRNA CTD PMID:16917069 NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression ISO Tetracycline results in decreased expression of HMGCS2 mRNA CTD PMID:24489787 NCBI chr 2:188,564,348...188,590,872
Ensembl chr 2:188,547,767...188,592,242 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Tetracycline results in increased expression of HMOX1 mRNA CTD PMID:19224547 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases expression EXP
ISO 		Tetracycline results in decreased expression of HNF4A mRNA CTD PMID:24469900 PMID:24489787 NCBI chr 3:172,606,220...172,667,758
Ensembl chr 3:172,606,220...172,667,758 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase decreases expression ISO Tetracycline results in decreased expression of HPGD mRNA CTD PMID:24489787 NCBI chr16:38,996,876...39,034,831
Ensembl chr16:38,996,876...39,034,831 		JBrowse link
G Hpn hepsin decreases expression EXP Tetracycline results in decreased expression of HPN mRNA CTD PMID:19224547 NCBI chr 1:95,464,468...95,480,169
Ensembl chr 1:95,464,470...95,480,199 		JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 increases expression ISO Tetracycline results in increased expression of HSD17B1 mRNA CTD PMID:16917069 NCBI chr10:86,510,011...86,512,211
Ensembl chr10:86,510,011...86,512,210 		JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 increases expression ISO Tetracycline results in increased expression of HSD17B2 mRNA CTD PMID:16917069 NCBI chr19:62,662,320...62,733,944
Ensembl chr19:62,662,098...62,733,943 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 decreases expression ISO Tetracycline results in decreased expression of HSD17B4 mRNA CTD PMID:24489787 NCBI chr18:45,515,427...45,604,467
Ensembl chr18:45,515,373...45,604,467 		JBrowse link
G Hsd3b7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 increases expression ISO Tetracycline results in increased expression of HSD3B7 mRNA CTD PMID:16917069 NCBI chr 1:191,842,688...191,845,919
Ensembl chr 1:191,842,636...191,845,921 		JBrowse link
G Hsf2 heat shock transcription factor 2 decreases expression ISO Tetracycline results in decreased expression of HSF2 mRNA CTD PMID:24489787 NCBI chr20:37,366,301...37,393,922
Ensembl chr20:37,366,279...37,401,022 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 increases expression ISO Tetracycline results in increased expression of HSP90B1 mRNA CTD PMID:16917069 NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:22,997,962...23,012,293 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression EXP Tetracycline results in increased expression of HSPA1A mRNA CTD PMID:17522070 NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression EXP Tetracycline results in increased expression of HSPD1 protein CTD PMID:16538043 NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression EXP Tetracycline results in increased expression of ICAM1 mRNA CTD PMID:17522070 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 decreases expression ISO Tetracycline results in decreased expression of IDH1 mRNA CTD PMID:24489787 NCBI chr 9:74,027,887...74,057,442
Ensembl chr 9:74,027,892...74,049,555 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression EXP
ISO 		Tetracycline results in increased expression of IGFBP1 mRNA CTD PMID:17522070 PMID:27089845 NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344 		JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 decreases expression ISO Tetracycline results in decreased expression of IGFBP2 mRNA CTD PMID:24489787 NCBI chr 9:81,864,811...81,892,179
Ensembl chr 9:81,864,783...81,892,171 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 decreases expression ISO Tetracycline results in decreased expression of IGFBP3 mRNA CTD PMID:24489787 NCBI chr14:86,270,208...86,277,944
Ensembl chr14:86,270,208...86,277,944 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression 		ISO Tetracycline analog inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Tetracycline inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Tetracycline inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]
Tetracycline results in decreased expression of IL1B mRNA 		CTD PMID:17267227 PMID:24489787 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 decreases expression ISO Tetracycline results in decreased expression of IL6 mRNA CTD PMID:24489787 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Tetracycline results in increased expression of INHBE mRNA CTD PMID:17175557 NCBI chr 7:65,061,531...65,064,519
Ensembl chr 7:65,061,531...65,064,519 		JBrowse link
G Inpp5f inositol polyphosphate-5-phosphatase F increases expression ISO Tetracycline results in increased expression of INPP5F mRNA CTD PMID:16917069 NCBI chr 1:192,620,891...192,700,681
Ensembl chr 1:192,620,891...192,700,681 		JBrowse link
G Insig2 insulin induced gene 2 increases expression ISO Tetracycline results in increased expression of INSIG2 mRNA CTD PMID:16917069 NCBI chr13:35,025,160...35,052,937
Ensembl chr13:35,025,164...35,047,658 		JBrowse link
G Isyna1 inositol-3-phosphate synthase 1 decreases expression ISO Tetracycline results in decreased expression of ISYNA1 mRNA CTD PMID:24489787 NCBI chr16:18,873,119...18,876,116
Ensembl chr16:18,873,121...18,875,955 		JBrowse link
G Itga3 integrin subunit alpha 3 decreases expression ISO Tetracycline results in decreased expression of ITGA3 mRNA CTD PMID:28882639 NCBI chr10:80,486,998...80,522,548
Ensembl chr10:80,486,999...80,518,901 		JBrowse link
G Itga5 integrin subunit alpha 5 increases expression ISO Tetracycline results in increased expression of ITGA5 mRNA CTD PMID:28882639 NCBI chr 7:136,358,097...136,381,305
Ensembl chr 7:136,358,097...136,381,305 		JBrowse link
G Itgae integrin subunit alpha E increases expression ISO Tetracycline results in increased expression of ITGAE mRNA CTD PMID:16917069 NCBI chr10:58,203,331...58,262,606
Ensembl chr10:58,203,364...58,262,606 		JBrowse link
G Itgal integrin subunit alpha L decreases expression ISO Tetracycline results in decreased expression of ITGAL mRNA CTD PMID:28882639 NCBI chr 1:191,348,424...191,386,228
Ensembl chr 1:191,348,542...191,386,225 		JBrowse link
G Itgam integrin subunit alpha M decreases expression ISO Tetracycline results in decreased expression of ITGAM mRNA CTD PMID:28882639 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 increases expression ISO Tetracycline results in increased expression of JAG1 mRNA CTD PMID:16917069 NCBI chr 3:144,859,453...144,894,883
Ensembl chr 3:144,859,453...144,894,872 		JBrowse link
G Jak1 Janus kinase 1 increases expression ISO Tetracycline results in increased expression of JAK1 mRNA CTD PMID:16917069 NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:120,896,046...120,996,758 		JBrowse link
G Kera keratocan increases expression ISO Tetracycline results in increased expression of KERA mRNA CTD PMID:16917069 NCBI chr 7:34,284,100...34,291,555
Ensembl chr 7:34,284,100...34,291,555 		JBrowse link
G Krt18 keratin 18 increases expression EXP Tetracycline results in increased expression of KRT18 mRNA CTD PMID:17522070 NCBI chr 7:135,036,168...135,039,844
Ensembl chr 7:135,035,982...135,039,848
Ensembl chr10:135,035,982...135,039,848 		JBrowse link
G Krt8 keratin 8 increases expression EXP Tetracycline results in increased expression of KRT8 mRNA CTD PMID:17522070 NCBI chr 7:135,002,886...135,010,339
Ensembl chr 7:135,002,894...135,010,403 		JBrowse link
G Lbp lipopolysaccharide binding protein increases expression EXP Tetracycline results in increased expression of LBP mRNA CTD PMID:17522070 NCBI chr 3:167,373,786...167,400,941
Ensembl chr 3:167,373,924...167,401,518 		JBrowse link
G Lcat lecithin cholesterol acyltransferase decreases expression ISO Tetracycline results in decreased expression of LCAT mRNA CTD PMID:24489787 NCBI chr19:50,744,598...50,748,064
Ensembl chr19:50,744,601...50,748,081 		JBrowse link
G Lgals3 galectin 3 increases expression EXP Tetracycline results in increased expression of LGALS3 mRNA CTD PMID:17522070 NCBI chr15:23,099,795...23,111,731
Ensembl chr15:23,086,841...23,111,737 		JBrowse link
G Lipc lipase C, hepatic type decreases expression EXP Tetracycline results in decreased expression of LIPC mRNA CTD PMID:17522070 NCBI chr 8:80,390,470...80,516,463
Ensembl chr 8:80,390,471...80,516,285 		JBrowse link
G Lpl lipoprotein lipase increases expression EXP Tetracycline results in increased expression of LPL mRNA CTD PMID:17522070 NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107 		JBrowse link
G Lrig3 leucine-rich repeats and immunoglobulin-like domains 3 increases expression ISO Tetracycline results in increased expression of LRIG3 mRNA CTD PMID:16917069 NCBI chr 7:63,701,724...63,751,898
Ensembl chr 7:63,701,778...63,752,261 		JBrowse link
G Lrp4 LDL receptor related protein 4 decreases expression ISO Tetracycline results in decreased expression of LRP4 mRNA CTD PMID:16917069 NCBI chr 3:97,885,373...97,939,366
Ensembl chr 3:97,885,400...97,939,370 		JBrowse link
G Lrrc4b leucine rich repeat containing 4B increases expression ISO Tetracycline results in increased expression of LRRC4B mRNA CTD PMID:16917069 NCBI chr 1:104,058,558...104,092,831
Ensembl chr 1:104,072,128...104,093,298 		JBrowse link
G Mal mal, T-cell differentiation protein increases expression ISO Tetracycline results in increased expression of MAL mRNA CTD PMID:16917069 NCBI chr 3:135,317,664...135,341,423
Ensembl chr 3:135,317,664...135,341,423 		JBrowse link
G Maob monoamine oxidase B decreases expression EXP
ISO 		Tetracycline results in decreased expression of MAOB mRNA CTD PMID:17522070 PMID:24489787 NCBI chr  X:8,490,405...8,594,065
Ensembl chr  X:8,490,344...8,594,375 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO Tetracycline results in decreased phosphorylation of MAPK1 protein CTD PMID:25745068 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO Tetracycline results in decreased phosphorylation of MAPK3 protein CTD PMID:25745068 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mat1a methionine adenosyltransferase 1A decreases expression ISO Tetracycline results in decreased expression of MAT1A mRNA CTD PMID:24489787 NCBI chr16:17,017,168...17,035,368
Ensembl chr16:17,016,030...17,035,367 		JBrowse link
G Mcph1 microcephalin 1 increases expression ISO Tetracycline results in increased expression of MCPH1 mRNA CTD PMID:16917069 NCBI chr16:77,724,251...77,926,773
Ensembl chr16:77,724,251...77,926,462 		JBrowse link
G Me1 malic enzyme 1 increases expression EXP Tetracycline results in increased expression of ME1 protein CTD PMID:16538043 NCBI chr 8:96,429,057...96,540,244
Ensembl chr 8:96,429,057...96,540,275 		JBrowse link
G Mgat2 alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase increases expression ISO Tetracycline results in increased expression of MGAT2 mRNA CTD PMID:16917069 NCBI chr 6:93,392,416...93,394,905
Ensembl chr 6:93,390,555...93,395,176 		JBrowse link
G Mipep mitochondrial intermediate peptidase decreases expression ISO Tetracycline results in decreased expression of MIPEP mRNA CTD PMID:24489787 NCBI chr15:39,102,301...39,227,915
Ensembl chr15:39,102,115...39,227,914 		JBrowse link
G Mir16-2 microRNA 16-2 increases expression EXP Tetracycline results in increased expression of MIR16-2 mRNA CTD PMID:17522070 NCBI chr 2:155,555,327...155,555,421
Ensembl chr 2:155,555,327...155,555,421 		JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions
decreases activity 		ISO Tetracycline analog inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Tetracycline inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]
Tetracycline analog results in decreased activity of MMP13 protein 		CTD PMID:17267227 NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases activity ISO Tetracycline analog results in decreased activity of MMP2 protein CTD PMID:17267227 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions
decreases expression
decreases activity 		ISO Tetracycline inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]
Tetracycline results in decreased expression of MMP3 mRNA
Tetracycline results in decreased activity of MMP3 protein 		CTD PMID:17267227 PMID:24489787 NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826 		JBrowse link
G Mmp8 matrix metallopeptidase 8 decreases activity ISO Tetracycline analog results in decreased activity of MMP8 protein CTD PMID:17267227 NCBI chr 8:13,008,873...13,018,729
Ensembl chr 8:13,008,890...13,018,729 		JBrowse link
G Mrps12 mitochondrial ribosomal protein S12 increases expression ISO Tetracycline results in increased expression of MRPS12 mRNA CTD PMID:16917069 NCBI chr 1:93,153,424...93,156,422
Ensembl chr 1:93,153,425...93,159,629 		JBrowse link
G Mtmr11 myotubularin related protein 11 increases expression ISO Tetracycline results in increased expression of MTMR11 mRNA CTD PMID:16917069 NCBI chr 2:186,410,851...186,421,024
Ensembl chr 2:186,412,291...186,421,026 		JBrowse link
G Mttp microsomal triglyceride transfer protein decreases expression ISO Tetracycline results in decreased expression of MTTP mRNA CTD PMID:24489787 PMID:27089845 NCBI chr 2:229,286,501...229,327,650
Ensembl chr 2:229,286,501...229,327,650 		JBrowse link
G Mug1 murinoglobulin 1 decreases expression EXP Tetracycline results in decreased expression of MUG1 mRNA CTD PMID:17522070 NCBI chr 4:156,748,351...156,802,132 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
increases expression 		EXP Tetracycline results in decreased expression of MYC mRNA
Tetracycline results in increased expression of MYC mRNA 		CTD PMID:17202758 PMID:17522070 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Ndrg2 NDRG family member 2 decreases expression EXP Tetracycline results in decreased expression of NDRG2 protein CTD PMID:16538043 NCBI chr15:27,074,481...27,087,376
Ensembl chr15:27,074,481...27,083,125 		JBrowse link
G Nefh neurofilament heavy chain affects expression EXP Tetracycline affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr14:84,044,428...84,054,413
Ensembl chr14:84,044,023...84,054,417 		JBrowse link
G Neu3 neuraminidase 3 increases expression ISO Tetracycline results in increased expression of NEU3 mRNA CTD PMID:16917069 NCBI chr 1:163,549,834...163,560,997
Ensembl chr 1:163,549,738...163,561,049 		JBrowse link
G Nfkbib NFKB inhibitor beta increases expression EXP Tetracycline results in increased expression of NFKBIB mRNA CTD PMID:17522070 NCBI chr 1:93,173,817...93,181,387
Ensembl chr 1:93,173,820...93,326,366 		JBrowse link
G Notch3 notch receptor 3 decreases expression ISO Tetracycline results in decreased expression of NOTCH3 mRNA CTD PMID:28882639 NCBI chr 7:11,783,550...11,834,585
Ensembl chr 7:11,784,272...11,834,778 		JBrowse link
G Notch4 notch receptor 4 decreases expression ISO Tetracycline results in decreased expression of NOTCH4 mRNA CTD PMID:28882639 NCBI chr20:4,164,969...4,189,072
Ensembl chr20:4,161,730...4,189,072 		JBrowse link
G Nox4 NADPH oxidase 4 decreases expression ISO Tetracycline results in decreased expression of NOX4 mRNA CTD PMID:24489787 NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483 		JBrowse link
G Npm2 nucleophosmin/nucleoplasmin 2 increases expression ISO Tetracycline results in increased expression of NPM2 mRNA CTD PMID:16917069 NCBI chr15:52,131,973...52,145,710
Ensembl chr15:52,132,058...52,139,027 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression EXP
ISO 		Tetracycline results in decreased expression of NQO1 mRNA CTD PMID:19224547 PMID:24489787 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression ISO Tetracycline results in decreased expression of NR1H4 mRNA CTD PMID:24489787 NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 decreases expression ISO Tetracycline results in decreased expression of NR1I3 mRNA CTD PMID:24489787 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370 		JBrowse link
G Nr2e3 nuclear receptor subfamily 2, group E, member 3 increases expression ISO Tetracycline results in increased expression of NR2E3 mRNA CTD PMID:16917069 NCBI chr 8:69,261,343...69,269,081
Ensembl chr 8:69,261,343...69,269,081 		JBrowse link
G Nsdhl NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL increases expression ISO Tetracycline results in increased expression of NSDHL mRNA CTD PMID:16917069 NCBI chr  X:155,817,301...155,848,224
Ensembl chr  X:155,817,340...155,848,220 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Tetracycline results in increased expression of NUPR1 mRNA CTD PMID:17175557 NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:190,643,867...190,645,901 		JBrowse link
G Odc1 ornithine decarboxylase 1 increases expression EXP Tetracycline results in increased expression of ODC1 mRNA CTD PMID:17522070 NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:46,058,463...46,065,146 		JBrowse link
G Onecut1 one cut homeobox 1 decreases expression ISO Tetracycline results in decreased expression of ONECUT1 mRNA CTD PMID:24489787 NCBI chr 8:84,480,066...84,507,848
Ensembl chr 8:84,480,305...84,508,124 		JBrowse link
G Osbpl3 oxysterol binding protein-like 3 decreases expression ISO Tetracycline results in decreased expression of OSBPL3 mRNA CTD PMID:16917069 NCBI chr 4:80,677,383...80,854,169
Ensembl chr 4:80,677,390...80,854,169 		JBrowse link
G Osbpl8 oxysterol binding protein-like 8 decreases expression ISO Tetracycline results in decreased expression of OSBPL8 mRNA CTD PMID:16917069 NCBI chr 7:48,483,259...48,636,151
Ensembl chr 7:48,483,022...48,636,151 		JBrowse link
G Otc ornithine transcarbamylase decreases expression EXP
ISO 		Tetracycline results in decreased expression of OTC mRNA CTD PMID:17522070 PMID:24489787 NCBI chr  X:15,126,358...15,202,473
Ensembl chr  X:15,126,358...15,239,555 		JBrowse link
G Pah phenylalanine hydroxylase decreases expression ISO Tetracycline results in decreased expression of PAH mRNA CTD PMID:24489787 NCBI chr 7:23,793,096...23,885,631
Ensembl chr 7:23,792,781...23,885,627 		JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 increases expression ISO Tetracycline results in increased expression of PAK2 mRNA CTD PMID:16917069 NCBI chr11:82,212,896...82,273,803
Ensembl chr11:82,212,951...82,273,803 		JBrowse link
G Paqr7 progestin and adipoQ receptor family member 7 decreases expression ISO Tetracycline results in decreased expression of PAQR7 mRNA CTD PMID:16917069 NCBI chr 5:151,992,849...152,004,267
Ensembl chr 5:151,992,801...152,006,167 		JBrowse link
G Paqr9 progestin and adipoQ receptor family member 9 increases expression ISO Tetracycline results in increased expression of PAQR9 mRNA CTD PMID:16917069 NCBI chr 8:104,993,884...104,996,180
Ensembl chr 8:104,993,827...104,998,285 		JBrowse link
G Pc pyruvate carboxylase increases expression ISO Tetracycline results in increased expression of PCX mRNA CTD PMID:16917069 NCBI chr 1:211,228,708...211,327,792
Ensembl chr 1:211,228,731...211,329,940 		JBrowse link
G Pcdh18 protocadherin 18 increases expression ISO Tetracycline results in increased expression of PCDH18 mRNA CTD PMID:16917069 NCBI chr 2:135,982,929...135,996,917
Ensembl chr 2:135,983,144...135,996,826 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 decreases expression ISO Tetracycline results in decreased expression of PCK1 mRNA CTD PMID:24489787 NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561 		JBrowse link
G Pctp phosphatidylcholine transfer protein decreases expression ISO Tetracycline results in decreased expression of PCTP mRNA CTD PMID:16917069 NCBI chr10:75,305,999...75,351,919
Ensembl chr10:75,305,999...75,326,432 		JBrowse link
G Pde4b phosphodiesterase 4B increases expression ISO Tetracycline results in increased expression of PDE4B mRNA CTD PMID:16917069 NCBI chr 5:122,028,956...122,598,267
Ensembl chr 5:122,135,174...122,598,267 		JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase increases expression ISO Tetracycline results in increased expression of PECR mRNA CTD PMID:16917069 NCBI chr 9:81,347,170...81,375,809
Ensembl chr 9:81,347,173...81,375,806 		JBrowse link
G Pi4kb phosphatidylinositol 4-kinase beta increases expression ISO Tetracycline results in increased expression of PI4KB mRNA CTD PMID:16917069 NCBI chr 2:185,229,392...185,261,697
Ensembl chr 2:185,228,799...185,261,693 		JBrowse link
G Pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha increases expression ISO Tetracycline results in increased expression of PIK3C2A mRNA CTD PMID:16917069 NCBI chr 1:180,012,248...180,117,786
Ensembl chr 1:180,012,248...180,117,773 		JBrowse link
G Pik3c2g phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma increases expression ISO Tetracycline results in increased expression of PIK3C2G mRNA CTD PMID:16917069 NCBI chr 4:174,215,527...174,583,378
Ensembl chr 4:174,215,527...174,581,705 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha increases expression ISO Tetracycline results in increased expression of PIK3CA mRNA CTD PMID:16917069 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta increases expression ISO Tetracycline results in increased expression of PIK3CB mRNA CTD PMID:16917069 NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:108,474,019...108,579,331 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta decreases expression ISO Tetracycline results in decreased expression of PIK3CD mRNA CTD PMID:16917069 NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:165,377,994...165,403,968 		JBrowse link
G Pip4k2b phosphatidylinositol-5-phosphate 4-kinase type 2 beta decreases expression ISO Tetracycline results in decreased expression of PIP4K2B mRNA CTD PMID:16917069 NCBI chr10:83,202,379...83,231,292
Ensembl chr10:83,197,287...83,231,292 		JBrowse link
G Pip5k1a phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha increases expression ISO Tetracycline results in increased expression of PIP5K1A mRNA CTD PMID:16917069 NCBI chr 2:185,317,319...185,361,859
Ensembl chr 2:185,317,319...185,360,476 		JBrowse link
G Pip5k1b phosphatidylinositol-4-phosphate 5-kinase type 1 beta increases expression ISO Tetracycline results in increased expression of PIP5K1B mRNA CTD PMID:16917069 NCBI chr 1:231,331,836...231,610,092
Ensembl chr 1:231,340,606...231,496,812 		JBrowse link
G Pitpna phosphatidylinositol transfer protein, alpha increases expression ISO Tetracycline results in increased expression of PITPNA mRNA CTD PMID:16917069 NCBI chr10:60,929,050...60,969,614
Ensembl chr10:60,929,007...60,971,830 		JBrowse link
G Pkd1l3 polycystin 1 like 3, transient receptor potential channel interacting increases expression ISO Tetracycline results in increased expression of PKD1L3 mRNA CTD PMID:16917069 NCBI chr19:54,494,529...54,559,596
Ensembl chr19:54,495,243...54,559,546 		JBrowse link
G Pklr pyruvate kinase L/R decreases expression EXP Tetracycline results in decreased expression of PKLR mRNA CTD PMID:17522070 PMID:19224547 NCBI chr 2:176,840,779...176,849,637
Ensembl chr 2:176,840,764...176,849,644 		JBrowse link
G Pla2g2a phospholipase A2 group IIA decreases expression ISO Tetracycline results in decreased expression of PLA2G2A mRNA CTD PMID:16917069 NCBI chr 5:156,359,725...156,362,302
Ensembl chr 5:156,359,725...156,362,297 		JBrowse link
G Pla2g2d phospholipase A2, group IID decreases expression ISO Tetracycline results in decreased expression of PLA2G2D mRNA CTD PMID:16917069 NCBI chr 5:156,299,374...156,305,816
Ensembl chr 5:156,297,777...156,305,812 		JBrowse link
G Plcg1 phospholipase C, gamma 1 increases expression ISO Tetracycline results in increased expression of PLCG1 mRNA CTD PMID:16917069 NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:169,804,846...169,836,050 		JBrowse link
G Plcz1 phospholipase C, zeta 1 increases expression ISO Tetracycline results in increased expression of PLCZ1 mRNA CTD PMID:16917069 NCBI chr 4:174,604,281...174,660,368
Ensembl chr 4:174,604,281...174,660,290 		JBrowse link
G Pld1 phospholipase D1 increases expression ISO Tetracycline results in increased expression of PLD1 mRNA CTD PMID:16917069 NCBI chr 2:112,777,820...112,975,857
Ensembl chr 2:112,777,951...112,976,245 		JBrowse link
G Plg plasminogen increases expression ISO Tetracycline results in increased expression of PLG mRNA CTD PMID:16917069 NCBI chr 1:50,872,927...50,915,406
Ensembl chr 1:50,872,926...50,917,320 		JBrowse link
G Plscr4 phospholipid scramblase 4 increases expression ISO Tetracycline results in increased expression of PLSCR4 mRNA CTD PMID:16917069 NCBI chr 8:101,867,057...101,905,827
Ensembl chr 8:101,866,888...101,905,831 		JBrowse link
G Polr2a RNA polymerase II subunit A increases expression ISO Tetracycline results in increased expression of POLR2A mRNA CTD PMID:16917069 NCBI chr10:54,951,162...54,977,179
Ensembl chr10:54,951,162...54,977,179 		JBrowse link
G Pomc proopiomelanocortin increases expression ISO Tetracycline results in increased expression of POMC mRNA CTD PMID:16917069 NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
decreases expression 		ISO
EXP 		bicyclol inhibits the reaction [Tetracycline results in decreased expression of PPARA mRNA] CTD PMID:19224547 PMID:19427351 PMID:24489787 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714 		JBrowse link
G Ppp1r3c protein phosphatase 1, regulatory subunit 3C increases expression ISO Tetracycline results in increased expression of PPP1R3C mRNA CTD PMID:16917069 NCBI chr 1:243,873,524...243,878,527
Ensembl chr 1:243,871,704...243,878,835 		JBrowse link
G Prkab2 protein kinase AMP-activated non-catalytic subunit beta 2 increases expression ISO Tetracycline results in increased expression of PRKAB2 mRNA CTD PMID:16917069 NCBI chr 2:187,946,008...187,961,615
Ensembl chr 2:187,945,982...187,961,608 		JBrowse link
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 increases expression ISO Tetracycline results in increased expression of PRKAG2 mRNA CTD PMID:16917069 NCBI chr 4:10,744,695...10,985,939
Ensembl chr 4:10,744,588...10,985,939 		JBrowse link
G Prnp prion protein affects binding
multiple interactions 		ISO Tetracycline binds to PRNP protein
Tetracycline inhibits the reaction [PRNP protein binds to PRNP protein] 		CTD PMID:10903871 NCBI chr 3:139,639,076...139,654,420
Ensembl chr 3:139,630,144...139,658,436 		JBrowse link
G Pten phosphatase and tensin homolog increases expression ISO Tetracycline results in increased expression of PTEN mRNA CTD PMID:16917069 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330 		JBrowse link
G Ptgds prostaglandin D2 synthase increases expression ISO Tetracycline results in increased expression of PTGDS mRNA CTD PMID:16917069 NCBI chr 3:28,680,044...28,682,978
Ensembl chr 3:28,680,044...28,682,978 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Tetracycline results in decreased expression of PTGS2 mRNA CTD PMID:24489787 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Ptma prothymosin alpha increases expression EXP Tetracycline results in increased expression of PTMA mRNA CTD PMID:17522070 NCBI chr 9:94,624,194...94,628,276
Ensembl chr 9:94,624,196...94,628,276 		JBrowse link
G Ptpmt1 protein tyrosine phosphatase, mitochondrial 1 decreases expression ISO Tetracycline results in decreased expression of PTPMT1 mRNA CTD PMID:16917069 NCBI chr 3:97,345,752...97,355,396
Ensembl chr 3:97,345,752...97,355,254 		JBrowse link
G Ptpn7 protein tyrosine phosphatase, non-receptor type 7 increases expression ISO Tetracycline results in increased expression of PTPN7 mRNA CTD PMID:16917069 NCBI chr13:49,122,679...49,136,096
Ensembl chr13:49,122,609...49,136,094 		JBrowse link
G Pvr PVR cell adhesion molecule increases expression EXP Tetracycline results in increased expression of PVR mRNA CTD PMID:17522070 NCBI chr 1:88,689,235...88,704,641
Ensembl chr 1:88,688,981...88,704,630 		JBrowse link
G Pygl glycogen phosphorylase L decreases expression EXP Tetracycline results in decreased expression of PYGL mRNA CTD PMID:17522070 NCBI chr 6:94,433,558...94,476,219
Ensembl chr 6:94,426,346...94,476,269 		JBrowse link
G Rab35 RAB35, member RAS oncogene family increases expression ISO Tetracycline results in increased expression of RAB35 mRNA CTD PMID:16917069 NCBI chr12:46,627,302...46,642,815
Ensembl chr12:46,627,864...46,645,426 		JBrowse link
G Rapgef5 Rap guanine nucleotide exchange factor 5 increases expression ISO Tetracycline results in increased expression of RAPGEF5 mRNA CTD PMID:16917069 NCBI chr 6:144,588,162...144,822,908
Ensembl chr 6:144,580,976...144,822,908 		JBrowse link
G Rgn regucalcin decreases expression EXP Tetracycline results in decreased expression of RGN mRNA CTD PMID:12883083 NCBI chr  X:4,172,537...4,190,112
Ensembl chr  X:4,172,537...4,190,251 		JBrowse link
G Rnpep arginyl aminopeptidase increases expression ISO Tetracycline results in increased expression of RNPEP mRNA CTD PMID:16917069 NCBI chr13:49,251,259...49,271,440
Ensembl chr13:49,251,264...49,269,799 		JBrowse link
G Rpl23 ribosomal protein L23 increases expression ISO Tetracycline results in increased expression of RPL23 mRNA CTD PMID:16917069 NCBI chr10:83,268,223...83,272,184
Ensembl chr10:83,262,592...83,272,214 		JBrowse link
G Rps6ka2 ribosomal protein S6 kinase A2 increases expression ISO Tetracycline results in increased expression of RPS6KA2 mRNA CTD PMID:16917069 NCBI chr 1:55,178,988...55,454,271
Ensembl chr 1:55,179,319...55,454,338 		JBrowse link
G Rxrg retinoid X receptor gamma increases expression ISO Tetracycline results in increased expression of RXRG mRNA CTD PMID:16917069 NCBI chr13:82,276,330...82,318,097
Ensembl chr13:82,276,291...82,318,095 		JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression EXP Tetracycline results in increased expression of S100A8 mRNA CTD PMID:17522070 NCBI chr 2:178,464,095...178,465,223
Ensembl chr 2:178,464,702...178,465,221 		JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression EXP Tetracycline results in increased expression of S100A9 mRNA CTD PMID:17522070 NCBI chr 2:178,487,941...178,490,622
Ensembl chr 2:178,487,941...178,490,870 		JBrowse link
G Sacm1l SAC1 like phosphatidylinositide phosphatase increases expression ISO Tetracycline results in increased expression of SACM1L mRNA CTD PMID:16917069 NCBI chr 8:132,053,465...132,109,857
Ensembl chr 8:132,053,049...132,109,857 		JBrowse link
G Sardh sarcosine dehydrogenase decreases expression ISO Tetracycline results in decreased expression of SARDH mRNA CTD PMID:24489787 NCBI chr 3:30,908,621...30,973,409
Ensembl chr 3:30,908,621...30,972,137 		JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP Tetracycline results in decreased expression of SCD mRNA CTD PMID:17202758 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785 		JBrowse link
G Sdr9c7 short chain dehydrogenase/reductase family 9C, member 7 increases expression ISO Tetracycline results in increased expression of SDR9C7 mRNA CTD PMID:16917069 NCBI chr 7:65,588,726...65,607,534
Ensembl chr 7:65,593,000...65,605,630 		JBrowse link
G Sec14l4 SEC14-like lipid binding 4 increases expression ISO Tetracycline results in increased expression of SEC14L4 mRNA CTD PMID:16917069 NCBI chr14:83,136,335...83,152,382
Ensembl chr14:83,136,339...83,153,215 		JBrowse link
G Sema6d semaphorin 6D increases expression ISO Tetracycline results in increased expression of SEMA6D mRNA CTD PMID:16917069 NCBI chr 3:131,801,680...132,394,578
Ensembl chr 3:132,337,343...132,394,584 		JBrowse link
G Serpina3n serpin family A member 3N increases expression ISO Tetracycline results in increased expression of SERPINA3 mRNA CTD PMID:17175557 NCBI chr 6:129,088,392...129,095,950
Ensembl chr 6:129,088,398...129,097,415 		JBrowse link
G Sgms1 sphingomyelin synthase 1 increases expression ISO Tetracycline results in increased expression of SGMS1 mRNA CTD PMID:16917069 NCBI chr 1:239,409,991...239,681,195
Ensembl chr 1:239,409,991...239,505,774 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression ISO
EXP 		Tetracycline results in decreased expression of SLC10A1 mRNA CTD PMID:24489787 PMID:27765674 NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944 		JBrowse link
G Slc10a2 solute carrier family 10 member 2 decreases expression ISO Tetracycline results in decreased expression of SLC10A2 mRNA CTD PMID:24489787 NCBI chr16:91,088,089...91,111,025
Ensembl chr16:91,076,423...91,111,025 		JBrowse link
G Slc16a7 solute carrier family 16 member 7 decreases expression ISO Tetracycline results in decreased expression of SLC16A7 mRNA CTD PMID:24489787 NCBI chr 7:62,929,067...63,096,995
Ensembl chr 7:62,936,567...63,040,386 		JBrowse link
G Slc1a4 solute carrier family 1 member 4 increases expression ISO Tetracycline results in increased expression of SLC1A4 mRNA CTD PMID:16917069 NCBI chr14:98,718,646...98,761,672
Ensembl chr14:98,730,450...98,761,790 		JBrowse link
G Slc22a25 solute carrier family 22, member 25 increases uptake
increases export
multiple interactions 		ISO SLC22A9 protein results in increased uptake of Tetracycline
SLC22A9 protein results in increased export of Tetracycline
Tetracycline inhibits the reaction [SLC22A9 protein results in increased uptake of Anions] 		CTD PMID:11855680 NCBI chr 1:214,767,837...214,956,535
Ensembl chr 1:214,767,837...214,862,340 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 increases export
multiple interactions
increases uptake 		ISO SLC22A6 protein results in increased export of Tetracycline
Tetracycline inhibits the reaction [SLC22A6 protein results in increased uptake of Anions]
SLC22A6 protein results in increased uptake of Tetracycline 		CTD PMID:11855680 NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions
increases uptake
increases transport 		ISO Acetaminophen inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]; Bumetanide inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]; Chloramphenicol inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]; Diclofenac inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]; Erythromycin inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]; Furosemide inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]; Ibuprofen inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]; Indomethacin inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]; Tetracycline inhibits the reaction [SLC22A7 protein results in increased uptake of Anions]
SLC22A7 protein results in increased uptake of Tetracycline 		CTD PMID:11855680 PMID:15901346 NCBI chr 9:22,044,672...22,052,051
Ensembl chr 9:22,045,435...22,051,681 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases uptake ISO SLC22A8 protein results in increased uptake of Tetracycline CTD PMID:11855680 NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588 		JBrowse link
G Slc25a15 solute carrier family 25 member 15 decreases expression ISO Tetracycline results in decreased expression of SLC25A15 mRNA CTD PMID:24489787 NCBI chr16:76,334,037...76,357,325
Ensembl chr16:76,324,288...76,357,321 		JBrowse link
G Slc25a17 solute carrier family 25 member 17 decreases expression ISO Tetracycline results in decreased expression of SLC25A17 mRNA CTD PMID:24489787 NCBI chr 7:114,724,533...114,767,163
Ensembl chr 7:114,724,533...114,767,345 		JBrowse link
G Slc25a20 solute carrier family 25 member 20 decreases expression ISO Tetracycline results in decreased expression of SLC25A20 mRNA CTD PMID:24489787 NCBI chr 8:118,243,573...118,265,027
Ensembl chr 8:118,243,519...118,265,027 		JBrowse link
G Slc25a30 solute carrier family 25, member 30 increases expression ISO Tetracycline results in increased expression of SLC25A30 mRNA CTD PMID:16917069 NCBI chr15:57,486,346...57,508,981
Ensembl chr15:57,486,350...57,502,690 		JBrowse link
G Slc27a2 solute carrier family 27 member 2 decreases expression ISO Tetracycline results in decreased expression of SLC27A2 mRNA CTD PMID:24489787 NCBI chr 3:134,258,101...134,295,581
Ensembl chr 3:134,258,101...134,295,581 		JBrowse link
G Slc27a5 solute carrier family 27 member 5 increases expression
decreases expression 		ISO Tetracycline results in increased expression of SLC27A5 mRNA
Tetracycline results in decreased expression of SLC27A5 protein 		CTD PMID:25745068 NCBI chr 1:82,688,742...82,699,335
Ensembl chr 1:82,688,750...82,699,358 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression EXP Tetracycline results in increased expression of SLC2A1 mRNA CTD PMID:17522070 NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 decreases expression ISO Tetracycline results in decreased expression of SLC2A2 mRNA CTD PMID:24489787 NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:113,537,972...113,568,467 		JBrowse link
G Slc2a3 solute carrier family 2 member 3 increases expression EXP Tetracycline results in increased expression of SLC2A3 mRNA CTD PMID:19224547 NCBI chr 4:157,632,887...157,698,034
Ensembl chr 4:157,632,887...157,646,186 		JBrowse link
G Slc2a5 solute carrier family 2 member 5 decreases expression EXP Tetracycline results in decreased expression of SLC2A5 mRNA CTD PMID:19224547 NCBI chr 5:165,857,412...165,892,928
Ensembl chr 5:165,866,172...165,894,038 		JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 decreases expression EXP Tetracycline results in decreased expression of SLCO1A1 mRNA CTD PMID:27765674 NCBI chr 4:176,606,924...176,682,027
Ensembl chr 4:176,607,687...176,681,992 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression EXP Tetracycline results in decreased expression of SLCO1B2 mRNA CTD PMID:17522070 NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083 		JBrowse link
G Sorl1 sortilin related receptor 1 decreases expression ISO Tetracycline results in decreased expression of SORL1 mRNA CTD PMID:16917069 NCBI chr 8:51,238,713...51,401,458
Ensembl chr 8:51,238,722...51,401,446 		JBrowse link
G Spin2b spindlin family member 2B decreases expression EXP Tetracycline results in decreased expression of SPIN2B mRNA CTD PMID:17522070 NCBI chr  X:19,923,341...19,925,119
Ensembl chr  X:19,842,295...19,925,734 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO Tetracycline results in increased expression of SPP1 mRNA CTD PMID:16917069 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820 		JBrowse link
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 increases expression ISO Tetracycline results in increased expression of SPTLC1 mRNA CTD PMID:16917069 NCBI chr17:12,029,189...12,068,234
Ensembl chr17:12,029,189...12,068,234 		JBrowse link
G Sptlc3 serine palmitoyltransferase, long chain base subunit 3 increases expression ISO Tetracycline results in increased expression of SPTLC3 mRNA CTD PMID:16917069 NCBI chr 3:147,301,570...147,431,696
Ensembl chr 3:147,301,801...147,434,044 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression
decreases expression 		ISO
EXP 		Tetracycline results in increased expression of SREBF1 mRNA
Tetracycline results in decreased expression of SREBF1 mRNA 		CTD PMID:16917069 PMID:17202758 PMID:17522070 PMID:24469900 PMID:27089845 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164 		JBrowse link
G St3gal1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 increases expression ISO Tetracycline results in increased expression of ST3GAL1 mRNA CTD PMID:16917069 NCBI chr 7:100,734,300...100,802,443
Ensembl chr 7:100,734,300...100,745,242 		JBrowse link
G St3gal4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 increases expression ISO Tetracycline results in increased expression of ST3GAL4 mRNA CTD PMID:16917069 NCBI chr 8:41,673,510...41,723,158
Ensembl chr 8:41,673,510...41,712,551 		JBrowse link
G Stam signal transducing adaptor molecule increases expression ISO Tetracycline results in increased expression of STAM mRNA CTD PMID:16917069 NCBI chr17:82,028,779...82,074,717
Ensembl chr17:82,028,703...82,075,013 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression EXP Tetracycline results in increased expression of STAT3 mRNA CTD PMID:17522070 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Sult2b1 sulfotransferase family 2B member 1 increases expression ISO Tetracycline results in increased expression of SULT2B1 mRNA CTD PMID:16917069 NCBI chr 1:105,336,614...105,397,744
Ensembl chr 1:105,336,614...105,397,744 		JBrowse link
G Tagln transgelin decreases expression ISO Tetracycline results in decreased expression of TAGLN mRNA CTD PMID:17175557 NCBI chr 8:55,121,647...55,127,121
Ensembl chr 8:55,121,301...55,127,563 		JBrowse link
G Tat tyrosine aminotransferase decreases expression ISO Tetracycline results in decreased expression of TAT mRNA CTD PMID:24489787 NCBI chr19:54,856,604...54,867,168
Ensembl chr19:54,856,563...54,867,482 		JBrowse link
G Tf transferrin decreases expression EXP Tetracycline results in decreased expression of TF protein CTD PMID:16538043 NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:112,647,642...112,695,400 		JBrowse link
G Thrsp thyroid hormone responsive decreases expression ISO
EXP 		Tetracycline results in decreased expression of THRSP mRNA CTD PMID:16917069 PMID:17522070 NCBI chr 1:161,134,640...161,138,964
Ensembl chr 1:161,133,453...161,139,827 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Tetracycline results in increased expression of TIMP1 mRNA CTD PMID:17522070 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression EXP Tetracycline results in increased expression of TNFRSF1A mRNA CTD PMID:17522070 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816 		JBrowse link
G Top2a DNA topoisomerase II alpha decreases expression EXP
ISO 		Tetracycline results in decreased expression of TOP2A mRNA
Tetracycline results in decreased expression of TOP2A protein 		CTD PMID:19224547 PMID:23293027 NCBI chr10:84,441,954...84,473,093
Ensembl chr10:84,441,954...84,473,366 		JBrowse link
G Tp53 tumor protein p53 increases expression EXP Tetracycline results in increased expression of TP53 mRNA CTD PMID:17522070 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Tspo translocator protein decreases expression ISO Tetracycline results in decreased expression of TSPO mRNA CTD PMID:16917069 NCBI chr 7:116,600,214...116,610,461
Ensembl chr 7:116,600,210...116,610,460 		JBrowse link
G Ttc1 tetratricopeptide repeat domain 1 increases expression ISO Tetracycline results in increased expression of TTC1 mRNA CTD PMID:16917069 NCBI chr10:28,703,763...28,728,910
Ensembl chr10:28,703,769...28,728,882 		JBrowse link
G Ttr transthyretin decreases expression EXP Tetracycline results in decreased expression of TTR mRNA CTD PMID:17522070 NCBI chr18:12,216,684...12,225,972
Ensembl chr18:12,216,732...12,225,969 		JBrowse link
G Tut1 terminal uridylyl transferase 1, U6 snRNA-specific increases expression ISO Tetracycline results in increased expression of TUT1 mRNA CTD PMID:16917069 NCBI chr 1:215,277,802...215,288,869 JBrowse link
G Txn1 thioredoxin 1 increases expression EXP Tetracycline results in increased expression of TXN mRNA CTD PMID:17522070 NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression
decreases expression 		EXP Tetracycline results in increased expression of TXNRD1 mRNA
Tetracycline results in decreased expression of TXNRD1 mRNA 		CTD PMID:17522070 PMID:19224547 NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817 		JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase increases expression ISO Tetracycline results in increased expression of UGCG mRNA CTD PMID:16917069 NCBI chr 5:78,828,006...78,860,725
Ensembl chr 5:78,828,006...78,860,417 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 decreases expression EXP Tetracycline results in decreased expression of UGT1A6 mRNA CTD PMID:19224547 NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt2a3 UDP glucuronosyltransferase family 2 member A3 increases expression ISO Tetracycline results in increased expression of UGT2A3 mRNA CTD PMID:16917069 NCBI chr14:20,851,970...20,869,974
Ensembl chr14:20,851,969...20,869,973 		JBrowse link
G Ugt3a1 UDP glycosyltransferase family 3 member A1 increases expression ISO Tetracycline results in increased expression of UGT3A1 mRNA CTD PMID:16917069 NCBI chr 2:60,062,257...60,077,354
Ensembl chr 2:60,061,775...60,077,354 		JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Tetracycline results in increased expression of WIPI1 mRNA CTD PMID:17175557 NCBI chr10:95,042,451...95,079,679
Ensembl chr10:95,042,441...95,079,293 		JBrowse link
G Zic5 Zic family member 5 increases expression ISO Tetracycline results in increased expression of ZIC5 mRNA CTD PMID:16917069 NCBI chr15:105,964,932...105,973,669
Ensembl chr15:105,964,932...105,973,669 		JBrowse link
tigecycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death multiple interactions EXP tigecycline inhibits the reaction [Lipopolysaccharides results in increased expression of BAD protein] CTD PMID:23200736 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP tigecycline inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein] CTD PMID:23200736 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP tigecycline inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein] CTD PMID:23200736 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO tigecycline inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of CCL3 protein]; tigecycline inhibits the reaction [enterotoxin F, Staphylococcal results in increased expression of CCL3 protein] CTD PMID:19874226 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO tigecycline inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of CCL4 protein]; tigecycline inhibits the reaction [enterotoxin F, Staphylococcal results in increased expression of CCL4 protein] CTD PMID:19874226 NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP tigecycline inhibits the reaction [Lipopolysaccharides affects the localization of CYCS protein] CTD PMID:23200736 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP 		tigecycline inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of IL1B protein]; tigecycline inhibits the reaction [enterotoxin F, Staphylococcal results in increased expression of IL1B protein]
Tigecycline inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Tigecycline inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] 		CTD PMID:19874226 PMID:23200736 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Tigecycline inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of IL6 protein]; Tigecycline inhibits the reaction [enterotoxin F, Staphylococcal results in increased expression of IL6 protein] CTD PMID:19874226 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP 		tigecycline inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of TNF protein]; tigecycline inhibits the reaction [enterotoxin F, Staphylococcal results in increased expression of TNF protein]
tigecycline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; tigecycline inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] 		CTD PMID:19874226 PMID:23200736 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        biochemical role 20264
          metabolite 20245
            tetracyclines 527
              (+)-viridicatumtoxin B 0
              (4R,12aR)-4,7-bis(dimethylamino)-10,12a-dihydroxy-1,3,11,12-tetraoxo-4,4a,5,5a,6,11a-hexahydrotetracene-2-carboxamide 0
              (4S,4aR,5S,12aS)-7-chloro-4-(dimethylamino)-5,10,12a-trihydroxy-6-methylene-1,3,11,12-tetraoxo-4a,5,5a,11a-tetrahydro-4H-tetracene-2-carboxamide 0
              (4S,4aS,5aR,12aS)-9-[[2-(tert-butylamino)-1-oxoethyl]amino]-4,7-bis(dimethylamino)-10,12a-dihydroxy-1,3,11,12-tetraoxo-4,4a,5,5a,6,11a-hexahydrotetracene-2-carboxamide 0
              (4S,4aS,5aR,6S,12aS)-7-chloro-4-(dimethylamino)-6,10,12a-trihydroxy-6-methyl-1,3,11,12-tetraoxo-4a,5,5a,11a-tetrahydro-4H-tetracene-2-carboxamide 0
              (4S,4aS,6S,12aS)-7-chloro-4-(dimethylamino)-6,10,12a-trihydroxy-6-methyl-1,3,11,12-tetraoxo-4a,5,5a,11a-tetrahydro-4H-tetracene-2-carboxamide 0
              (4aS,5aR,12aS)-10,12a-dihydroxy-1,3,11,12-tetraoxo-4,4a,5,5a,6,11a-hexahydrotetracene-2-carboxamide 0
              (4aS,5aS,12aS)-7-chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboximidic acid 0
              11a-Hydroxy-7-chlortetracycline 0
              11a-hydroxy-7-iodotetracycline zwitterion 0
              11a-hydroxychlortetracycline zwitterion 0
              11a-hydroxytetracycline 0
              11a-hydroxytigecycline(1+) 0
              12-dehydrotetracycline 0
              4-(dimethylamino)-5,10,12a-trihydroxy-6-methyl-1,3,11,12-tetraoxo-4,4a,5,5a,6,11a-hexahydrotetracene-2-carboxamide 0
              4-(dimethylamino)-6,10,12a-trihydroxy-6-methyl-1,3,11,12-tetraoxo-4a,5,5a,11a-tetrahydro-4H-tetracene-2-carboxamide 0
              4-Amino-anhydrotetracycline 0
              4-Aminoanhydrochlortetracycline 0
              4-Epianhydrotetracycline hydrochloride 0
              4-amino-4-de(dimethylamino)anhydrotetracycline 0
              4-de(dimethylamino)-4-oxoanhydrotetracycline 0
              4-dedimethylamine-4-oxo-anhydro-7-Cl-tetracycline 0
              4-epi-Chlortetracycline Hydrochloride 0
              5-Hydroxy-7-chlortetracycline 0
              5-hydroxyanthrotainin 0
              5a,11a-Dehydrochlortetracycline 0
              5a,11a-dehydrooxytetracycline 0
              5a,6-anhydrotetracycline 0
              6-demethyltetracycline 0
              7-chloro-4-(dimethylamino)-6,10,12a-trihydroxy-1,3,11,12-tetraoxo-4,4a,5,5a,6,11a-hexahydrotetracene-2-carboxamide 0
              8-O-desmethylanthrotainin 0
              Anhydrochlortetracycline 0
              Anhydrochlortetracycline hydrochloride 0
              Anhydrotetracycline hydrochloride 0
              Anthrotainin 0
              BMS-192548 0
              DMG-MINO 0
              Dactylocycline A 0
              Dactylocycline B 0
              Epianhydrochlortetracycline hydrochloride 0
              Epitetracycline hydrochloride 0
              Eravacycline 0
              Omadacycline 2
              Oxytetracycline Impurity A 0
              Pretetramid + 0
              Previridicatumtoxin 0
              SF2575 0
              Sancycline hydrochloride 0
              Sarecycline hydrochloride 0
              Sodium terramycin 0
              TAN-1518 A 0
              TAN-1518 B 0
              TAN-1612 0
              Viridicatumtoxin B 0
              a tetracycline zwitterion + 0
              anhydrotetracycline + 0
              chlortetracycline 2
              clomocycline 0
              demeclocycline + 3
              desmethylanhydrotetracycline 0
              doxycycline + 79
              guamecycline 0
              iodtetracycline(1-) + 0
              lymecycline 0
              meclocycline 6
              methacycline 0
              minocycline + 113
              nitrocycline 0
              oxytetracycline 10
              pipacycline 0
              pretetramide + 0
              rolitetracycline 0
              sancycline 0
              tetracycline + 380
              tigecycline + 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    main group molecular entity 20781
                      s-block molecular entity 20574
                        hydrogen molecular entity 20558
                          hydrides 19693
                            organic hydride 19079
                              organic fundamental parent 19079
                                hydrocarbon 18731
                                  cyclic hydrocarbon 17330
                                    arene 17311
                                      polycyclic arene 17112
                                        ortho-fused polycyclic arene 9959
                                          acene 7855
                                            tetracene 7852
                                              tetracyclines 527
                                                (+)-viridicatumtoxin B 0
                                                (4R,12aR)-4,7-bis(dimethylamino)-10,12a-dihydroxy-1,3,11,12-tetraoxo-4,4a,5,5a,6,11a-hexahydrotetracene-2-carboxamide 0
                                                (4S,4aR,5S,12aS)-7-chloro-4-(dimethylamino)-5,10,12a-trihydroxy-6-methylene-1,3,11,12-tetraoxo-4a,5,5a,11a-tetrahydro-4H-tetracene-2-carboxamide 0
                                                (4S,4aS,5aR,12aS)-9-[[2-(tert-butylamino)-1-oxoethyl]amino]-4,7-bis(dimethylamino)-10,12a-dihydroxy-1,3,11,12-tetraoxo-4,4a,5,5a,6,11a-hexahydrotetracene-2-carboxamide 0
                                                (4S,4aS,5aR,6S,12aS)-7-chloro-4-(dimethylamino)-6,10,12a-trihydroxy-6-methyl-1,3,11,12-tetraoxo-4a,5,5a,11a-tetrahydro-4H-tetracene-2-carboxamide 0
                                                (4S,4aS,6S,12aS)-7-chloro-4-(dimethylamino)-6,10,12a-trihydroxy-6-methyl-1,3,11,12-tetraoxo-4a,5,5a,11a-tetrahydro-4H-tetracene-2-carboxamide 0
                                                (4aS,5aR,12aS)-10,12a-dihydroxy-1,3,11,12-tetraoxo-4,4a,5,5a,6,11a-hexahydrotetracene-2-carboxamide 0
                                                (4aS,5aS,12aS)-7-chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboximidic acid 0
                                                11a-Hydroxy-7-chlortetracycline 0
                                                11a-hydroxy-7-iodotetracycline zwitterion 0
                                                11a-hydroxychlortetracycline zwitterion 0
                                                11a-hydroxytetracycline 0
                                                11a-hydroxytigecycline(1+) 0
                                                12-dehydrotetracycline 0
                                                4-(dimethylamino)-5,10,12a-trihydroxy-6-methyl-1,3,11,12-tetraoxo-4,4a,5,5a,6,11a-hexahydrotetracene-2-carboxamide 0
                                                4-(dimethylamino)-6,10,12a-trihydroxy-6-methyl-1,3,11,12-tetraoxo-4a,5,5a,11a-tetrahydro-4H-tetracene-2-carboxamide 0
                                                4-Amino-anhydrotetracycline 0
                                                4-Aminoanhydrochlortetracycline 0
                                                4-Epianhydrotetracycline hydrochloride 0
                                                4-amino-4-de(dimethylamino)anhydrotetracycline 0
                                                4-de(dimethylamino)-4-oxoanhydrotetracycline 0
                                                4-dedimethylamine-4-oxo-anhydro-7-Cl-tetracycline 0
                                                4-epi-Chlortetracycline Hydrochloride 0
                                                5-Hydroxy-7-chlortetracycline 0
                                                5-hydroxyanthrotainin 0
                                                5a,11a-Dehydrochlortetracycline 0
                                                5a,11a-dehydrooxytetracycline 0
                                                5a,6-anhydrotetracycline 0
                                                6-demethyltetracycline 0
                                                7-chloro-4-(dimethylamino)-6,10,12a-trihydroxy-1,3,11,12-tetraoxo-4,4a,5,5a,6,11a-hexahydrotetracene-2-carboxamide 0
                                                8-O-desmethylanthrotainin 0
                                                Anhydrochlortetracycline 0
                                                Anhydrochlortetracycline hydrochloride 0
                                                Anhydrotetracycline hydrochloride 0
                                                Anthrotainin 0
                                                BMS-192548 0
                                                DMG-MINO 0
                                                Dactylocycline A 0
                                                Dactylocycline B 0
                                                Epianhydrochlortetracycline hydrochloride 0
                                                Epitetracycline hydrochloride 0
                                                Eravacycline 0
                                                Omadacycline 2
                                                Oxytetracycline Impurity A 0
                                                Pretetramid + 0
                                                Previridicatumtoxin 0
                                                SF2575 0
                                                Sancycline hydrochloride 0
                                                Sarecycline hydrochloride 0
                                                Sodium terramycin 0
                                                TAN-1518 A 0
                                                TAN-1518 B 0
                                                TAN-1612 0
                                                Viridicatumtoxin B 0
                                                a tetracycline zwitterion + 0
                                                anhydrotetracycline + 0
                                                chlortetracycline 2
                                                clomocycline 0
                                                demeclocycline + 3
                                                desmethylanhydrotetracycline 0
                                                doxycycline + 79
                                                guamecycline 0
                                                iodtetracycline(1-) + 0
                                                lymecycline 0
                                                meclocycline 6
                                                methacycline 0
                                                minocycline + 113
                                                nitrocycline 0
                                                oxytetracycline 10
                                                pipacycline 0
                                                pretetramide + 0
                                                rolitetracycline 0
                                                sancycline 0
                                                tetracycline + 380
                                                tigecycline + 9
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