CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: tetracyclines
Accession: CHEBI:26895
browse the term
Definition: A subclass of polyketides having an octahydrotetracene-2-carboxamide skeleton, substituted with many hydroxy and other groups.
Synonyms: xref_mesh: MESH:D013754
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Cat
catalase
multiple interactions
ISO
[Resveratrol co-treated with Tetracyclines] inhibits the reaction [Paraquat results in decreased activity of CAT protein]; Tetracyclines inhibits the reaction [Paraquat results in decreased activity of CAT protein]
CTD
PMID:28090784
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
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Csf2
colony stimulating factor 2
multiple interactions
ISO
[Resveratrol co-treated with Tetracyclines] inhibits the reaction [Paraquat results in increased expression of CSF2 protein]
CTD
PMID:28090784
NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031
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Ifng
interferon gamma
multiple interactions
ISO
[Resveratrol co-treated with Tetracyclines] inhibits the reaction [Paraquat results in increased expression of IFNG protein]
CTD
PMID:28090784
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
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Il10
interleukin 10
multiple interactions
ISO
[Resveratrol co-treated with Tetracyclines] affects the reaction [Paraquat affects the expression of IL10 protein]
CTD
PMID:28090784
NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
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Il1a
interleukin 1 alpha
multiple interactions
ISO
[Resveratrol co-treated with Tetracyclines] inhibits the reaction [Paraquat results in increased expression of IL1A protein]
CTD
PMID:28090784
NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013
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Il4
interleukin 4
multiple interactions
ISO
[Resveratrol co-treated with Tetracyclines] inhibits the reaction [Paraquat results in increased expression of IL4 protein]
CTD
PMID:28090784
NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549
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Mmp9
matrix metallopeptidase 9
decreases activity
EXP
Tetracyclines results in decreased activity of MMP9 protein
CTD
PMID:11172685
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
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Mpo
myeloperoxidase
multiple interactions
ISO
[Resveratrol co-treated with Tetracyclines] inhibits the reaction [Paraquat results in increased activity of MPO protein]; Tetracyclines inhibits the reaction [Paraquat results in increased activity of MPO protein]
CTD
PMID:28090784
NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056
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Tnf
tumor necrosis factor
multiple interactions
ISO
[Resveratrol co-treated with Tetracyclines] inhibits the reaction [Paraquat results in increased expression of TNF protein]
CTD
PMID:28090784
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
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Cat
catalase
decreases activity
ISO
Chlortetracycline results in decreased activity of CAT protein
CTD
PMID:30768968
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
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Gstp1
glutathione S-transferase pi 1
multiple interactions
ISO
Chlortetracycline inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]
CTD
PMID:23769903
NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705
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Il1a
interleukin 1 alpha
multiple interactions
ISO
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Demeclocycline
CTD
PMID:19362101
NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013
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Il6
interleukin 6
multiple interactions
ISO
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Demeclocycline
CTD
PMID:19362101
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
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Tnf
tumor necrosis factor
multiple interactions
ISO
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Demeclocycline
CTD
PMID:19362101
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
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Abcb11
ATP binding cassette subfamily B member 11
decreases expression
EXP
Doxycycline results in decreased expression of ABCB11 mRNA
CTD
PMID:27765674
NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581
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Abcb1a
ATP binding cassette subfamily B member 1A
decreases expression increases expression multiple interactions
ISO
Doxycycline results in decreased expression of ABCB1 protein Doxycycline results in increased expression of ABCB1 protein MB protein inhibits the reaction [Doxycycline results in increased expression of ABCB1 protein]
CTD
PMID:11147995 PMID:38115220
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
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Abcb4
ATP binding cassette subfamily B member 4
decreases expression
EXP
Doxycycline results in decreased expression of ABCB4 mRNA
CTD
PMID:27765674
NCBI chr 4:26,106,895...26,164,440
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Abcc1
ATP binding cassette subfamily C member 1
increases expression multiple interactions
ISO
Doxycycline results in increased expression of ABCC1 protein MB protein inhibits the reaction [Doxycycline results in increased expression of ABCC1 protein]
CTD
PMID:38115220
NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404
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Abcc3
ATP binding cassette subfamily C member 3
decreases expression
EXP
Doxycycline results in decreased expression of ABCC3 mRNA
CTD
PMID:27765674
NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494
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Abcc4
ATP binding cassette subfamily C member 4
decreases expression
EXP
Doxycycline results in decreased expression of ABCC4 mRNA
CTD
PMID:27765674
NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375
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Abcg5
ATP binding cassette subfamily G member 5
increases expression
EXP
Doxycycline results in increased expression of ABCG5 mRNA
CTD
PMID:27765674
NCBI chr 6:15,717,936...15,743,376
Ensembl chr 6:15,717,936...15,743,376
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Acta2
actin alpha 2, smooth muscle
multiple interactions
ISO
Doxycycline inhibits the reaction [Isoproterenol results in decreased expression of ACTA2 mRNA]
CTD
PMID:18089841
NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503
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Ada
adenosine deaminase
multiple interactions
ISO
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of ADA mRNA]
CTD
PMID:18089841
NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:172,818,176...172,842,293
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Ahr
aryl hydrocarbon receptor
multiple interactions increases expression
ISO
[[Doxycycline results in increased expression of AHR protein] which co-treated with Tobacco Smoke Pollution] results in increased expression of CYP1B1 mRNA [Doxycycline results in increased expression of AHR protein] which results in increased expression of CYP1B1 mRNA; Doxycycline results in increased expression of AHR protein
CTD
PMID:22273977
NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901
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Ang
angiogenin
multiple interactions
ISO
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of ANG mRNA]
CTD
PMID:18089841
NCBI chr15:26,786,233...26,796,883
Ensembl chr15:26,786,065...26,801,106
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Arid3a
AT-rich interaction domain 3A
multiple interactions
ISO
Doxycycline promotes the reaction [erastin results in increased expression of ARID3A mRNA]
CTD
PMID:38115220
NCBI chr 7:10,403,161...10,431,551
Ensembl chr 7:10,405,631...10,427,926
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Atf2
activating transcription factor 2
multiple interactions
ISO
Doxycycline inhibits the reaction [Isoproterenol results in increased phosphorylation of ATF2 protein]
CTD
PMID:18089841
NCBI chr 3:79,125,814...79,202,896
Ensembl chr 3:79,126,705...79,202,745
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Bad
BCL2-associated agonist of cell death
multiple interactions
ISO
Doxycycline inhibits the reaction [Doxorubicin results in increased expression of BAD protein]
CTD
PMID:17673183
NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
Doxycycline inhibits the reaction [Doxorubicin results in increased expression of BAX protein]
CTD
PMID:17673183
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
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Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
Doxycycline inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]
CTD
PMID:17673183
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
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Bcl2l1
Bcl2-like 1
multiple interactions
ISO
Doxycycline inhibits the reaction [Doxorubicin results in decreased expression of BCL2L1 protein]
CTD
PMID:17673183
NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907 Ensembl chr 1:161,745,540...161,764,907
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Bnip3
BCL2 interacting protein 3
increases expression
EXP
Doxycycline increases expression of Bnip3 mRNA in cardiac myocytes
RGD
PMID:25489073
RGD:11561978
NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:203,137,778...203,154,962
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Casp3
caspase 3
multiple interactions
ISO
Doxycycline inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Doxycycline inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]
CTD
PMID:17673183
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
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Ccng2
cyclin G2
multiple interactions
ISO
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of CCNG2 mRNA]
CTD
PMID:18089841
NCBI chr14:15,088,694...15,097,190
Ensembl chr14:15,088,695...15,096,206
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
multiple interactions
ISO
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of CDKN1A mRNA]
CTD
PMID:18089841
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
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Cebpd
CCAAT/enhancer binding protein delta
multiple interactions
ISO
Doxycycline promotes the reaction [erastin results in increased expression of CEBPD mRNA]
CTD
PMID:38115220
NCBI chr11:98,268,856...98,269,994
Ensembl chr11:98,265,651...98,280,824
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Chst4
carbohydrate sulfotransferase 4
multiple interactions
ISO
Doxycycline promotes the reaction [erastin results in increased expression of CHST4 mRNA]
CTD
PMID:38115220
NCBI chr19:54,900,914...54,911,735
Ensembl chr19:54,882,719...54,916,648
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Cited2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
multiple interactions
ISO
[Doxycycline co-treated with erastin] results in increased expression of CITED2 mRNA
CTD
PMID:38115220
NCBI chr 1:14,132,303...14,134,746
Ensembl chr 1:14,103,457...14,134,782
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Creb1
cAMP responsive element binding protein 1
multiple interactions
ISO
[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the phosphorylation of CREB1 protein; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREB1 protein binds to NR4A1 promoter]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the phosphorylation of CREB1 protein]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREB1 protein binds to NR4A1 promoter]]
CTD
PMID:36565944
NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339
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Crebbp
CREB binding protein
multiple interactions
ISO
[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREBBP protein binds to NR4A1 promoter]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREBBP protein binds to NR4A1 promoter]]
CTD
PMID:36565944
NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,822,620...11,968,266
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
multiple interactions increases expression
ISO
[[Doxycycline results in increased expression of AHR protein] which co-treated with Tobacco Smoke Pollution] results in increased expression of CYP1B1 mRNA [Doxycycline results in increased expression of AHR protein] which results in increased expression of CYP1B1 mRNA
CTD
PMID:22273977
NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142
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Ddit4
DNA-damage-inducible transcript 4
multiple interactions
ISO
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of DDIT4 mRNA]
CTD
PMID:18089841
NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037
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Ezh2
enhancer of zeste 2 polycomb repressive complex 2 subunit
multiple interactions
ISO
[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [EZH2 protein binds to NR4A1 promoter]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [EZH2 protein binds to NR4A1 promoter]]
CTD
PMID:36565944
NCBI chr 4:77,624,223...77,698,598
Ensembl chr 4:77,624,223...77,687,183
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of FOS mRNA]
CTD
PMID:18089841
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
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Gabarapl1
GABA type A receptor associated protein like 1
multiple interactions
ISO
Doxycycline promotes the reaction [erastin results in increased expression of GABARAPL1 mRNA]
CTD
PMID:38115220
NCBI chr 4:164,666,332...164,675,474
Ensembl chr 4:164,666,246...164,674,578
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Gap43
growth associated protein 43
increases expression
EXP
Doxycycline results in increased expression of GAP43 protein
CTD
PMID:33798505
NCBI chr11:71,882,131...71,975,799
Ensembl chr11:71,882,131...71,975,797
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Gdnf
glial cell derived neurotrophic factor
multiple interactions
ISO
[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the expression of NR4A1 mRNA; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the expression of NR4A1 protein; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the methylation of NR4A1 promoter; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the phosphorylation of CREB1 protein; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREB1 protein binds to NR4A1 promoter]; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREBBP protein binds to NR4A1 promoter]; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [EZH2 protein binds to NR4A1 promoter]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the expression of NR4A1 mRNA]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the expression of NR4A1 protein]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the methylation of NR4A1 promoter]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the phosphorylation of CREB1 protein]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREB1 protein binds to NR4A1 promoter]]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREBBP protein binds to NR4A1 promoter]]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [EZH2 protein binds to NR4A1 promoter]]
CTD
PMID:36565944
NCBI chr 2:58,621,327...58,647,242
Ensembl chr 2:58,621,327...58,647,240
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Gem
GTP binding protein overexpressed in skeletal muscle
multiple interactions
ISO
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of GEM mRNA]
CTD
PMID:18089841
NCBI chr 5:30,011,641...30,022,554
Ensembl chr 5:30,011,592...30,022,542
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Gja1
gap junction protein, alpha 1
multiple interactions
ISO
Doxycycline inhibits the reaction [Isoproterenol results in decreased expression of GJA1 mRNA]
CTD
PMID:18089841
NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689
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Gpx4
glutathione peroxidase 4
multiple interactions decreases expression
ISO
MB protein promotes the reaction [Doxycycline results in decreased expression of GPX4 protein]
CTD
PMID:38115220
NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629
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Gstp1
glutathione S-transferase pi 1
multiple interactions
ISO
Doxycycline inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]
CTD
PMID:23769903
NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705
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Hmga2
high mobility group AT-hook 2
multiple interactions
ISO
Doxycycline promotes the reaction [erastin results in increased expression of HMGA2 mRNA]
CTD
PMID:38115220
NCBI chr 7:57,762,710...57,884,555
Ensembl chr 7:57,765,675...57,880,341
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Hmox1
heme oxygenase 1
increases expression multiple interactions increases response to substance
ISO
Doxycycline results in increased expression of HMOX1 protein Doxycycline promotes the reaction [erastin results in increased expression of HMOX1 mRNA]; ferrostatin-1 inhibits the reaction [HMOX1 protein results in increased susceptibility to Doxycycline]; MB protein promotes the reaction [Doxycycline results in increased expression of HMOX1 protein]
CTD
PMID:38115220
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
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Il1b
interleukin 1 beta
multiple interactions
ISO
Doxycycline analog inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]
CTD
PMID:17267227
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
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Il6
interleukin 6
multiple interactions
ISO
Doxycycline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
CTD
PMID:25977597
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
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Krt5
keratin 5
multiple interactions
ISO
Doxycycline promotes the reaction [erastin results in increased expression of KRT5 mRNA]
CTD
PMID:38115220
NCBI chr 7:134,724,840...134,730,569
Ensembl chr 7:134,724,840...134,730,569
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Lcn2
lipocalin 2
multiple interactions
ISO
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of LCN2 mRNA]
CTD
PMID:18089841
NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842
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Map3k6
mitogen-activated protein kinase kinase kinase 6
multiple interactions
ISO
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MAP3K6 mRNA]
CTD
PMID:18089841
NCBI chr 5:150,724,029...150,736,113
Ensembl chr 5:150,724,216...150,736,111
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Map3k8
mitogen-activated protein kinase kinase kinase 8
multiple interactions
ISO
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MAP3K8 mRNA]
CTD
PMID:18089841
NCBI chr17:58,078,175...58,098,455
Ensembl chr17:58,078,320...58,098,452
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Mapk14
mitogen activated protein kinase 14
multiple interactions
ISO
Doxycycline inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK14 protein]
CTD
PMID:18089841
NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294
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Mb
myoglobin
increases response to substance increases expression multiple interactions
ISO
MB protein results in increased susceptibility to Doxycycline Doxycycline results in increased expression of MB protein Doxycycline promotes the reaction [erastin results in increased expression of MB mRNA]; MB protein inhibits the reaction [Doxycycline results in increased expression of ABCB1 protein]; MB protein inhibits the reaction [Doxycycline results in increased expression of ABCC1 protein]; MB protein promotes the reaction [Doxycycline results in decreased expression of GPX4 protein]; MB protein promotes the reaction [Doxycycline results in increased expression of HMOX1 protein]
CTD
PMID:38115220
NCBI chr 7:110,640,511...110,647,742
Ensembl chr 7:110,640,512...110,647,958
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Mmp13
matrix metallopeptidase 13
multiple interactions decreases activity increases expression
ISO
Doxycycline analog inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA] Doxycycline analog results in decreased activity of MMP13 protein Doxycycline results in increased expression of MMP13 mRNA
CTD
PMID:17267227 PMID:20338993
NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105
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Mmp2
matrix metallopeptidase 2
multiple interactions decreases activity decreases expression
ISO EXP
Doxycycline inhibits the reaction [Isoproterenol results in increased activity of MMP2] Doxycycline analog results in decreased activity of MMP2 protein Doxycycline results in decreased expression of MMP2 protein Doxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP2 protein]; Doxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein] Doxycycline inhibits the reaction [angiotensin I (1-7) results in increased activity of MMP2 protein]; Doxycycline inhibits the reaction [Lead results in increased expression of and results in increased activity of MMP2 protein] Doxycycline results in decreased activity of MMP2 protein
CTD
PMID:17267227 PMID:17498959 PMID:18089841 PMID:18178469 PMID:18836702 PMID:19375915 PMID:20837116 More...
NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856
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Mmp3
matrix metallopeptidase 3
multiple interactions decreases activity
ISO
Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA] Doxycycline results in decreased activity of MMP3 protein Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MMP3 mRNA]
CTD
PMID:17267227 PMID:18089841
NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826
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Mmp8
matrix metallopeptidase 8
decreases activity
ISO
Doxycycline analog results in decreased activity of MMP8 protein
CTD
PMID:17267227
NCBI chr 8:13,008,873...13,018,729
Ensembl chr 8:13,008,890...13,018,729
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Mmp9
matrix metallopeptidase 9
multiple interactions decreases expression decreases activity
ISO EXP
Doxycycline inhibits the reaction [Isoproterenol results in increased activity of MMP9]; Doxycycline inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 mRNA]; Doxycycline inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 protein] Doxycycline results in decreased expression of MMP9 protein Doxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]; Doxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein] Doxycycline inhibits the reaction [angiotensin I (1-7) results in increased activity of MMP9 protein] Doxycycline results in decreased activity of MMP9 protein
CTD
PMID:15131573 PMID:17498959 PMID:18089841 PMID:18178469 PMID:19375915 PMID:20837116 More...
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
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Mt2
metallothionein 2
multiple interactions
ISO
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MT2 mRNA]
CTD
PMID:18089841
NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709
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Myh7
myosin heavy chain 7
multiple interactions
ISO
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MYH7 mRNA]
CTD
PMID:18089841
NCBI chr15:32,416,525...32,439,851
Ensembl chr15:32,416,527...32,438,194
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Nefh
neurofilament heavy chain
increases expression
EXP
Doxycycline results in increased expression of NEFH protein
CTD
PMID:33798505
NCBI chr14:84,044,428...84,054,413
Ensembl chr14:84,044,023...84,054,417
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Nos2
nitric oxide synthase 2
multiple interactions decreases expression
ISO
Doxycycline results in decreased stability of and results in decreased expression of NOS2 mRNA Doxycycline results in decreased expression of NOS2 protein
CTD
PMID:16365451
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
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Nox4
NADPH oxidase 4
multiple interactions
ISO
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of NOX4 mRNA]
CTD
PMID:18089841
NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483
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Nr4a1
nuclear receptor subfamily 4, group A, member 1
multiple interactions
ISO
[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the expression of NR4A1 mRNA; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the expression of NR4A1 protein; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the methylation of NR4A1 promoter; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREB1 protein binds to NR4A1 promoter]; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREBBP protein binds to NR4A1 promoter]; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [EZH2 protein binds to NR4A1 promoter]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the expression of NR4A1 mRNA]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the expression of NR4A1 protein]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the methylation of NR4A1 promoter]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREB1 protein binds to NR4A1 promoter]]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREBBP protein binds to NR4A1 promoter]]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [EZH2 protein binds to NR4A1 promoter]]
CTD
PMID:36565944
NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:134,247,192...134,268,041
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Ntrk1
neurotrophic receptor tyrosine kinase 1
increases phosphorylation
EXP
Doxycycline results in increased phosphorylation of NTRK1 protein
CTD
PMID:33798505
NCBI chr 2:175,534,844...175,551,664
Ensembl chr 2:175,534,844...175,551,787
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Osmr
oncostatin M receptor
multiple interactions
ISO
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of OSMR mRNA]
CTD
PMID:18089841
NCBI chr 2:57,634,517...57,688,802
Ensembl chr 2:57,634,517...57,688,561
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Pla2g7
phospholipase A2 group VII
multiple interactions
ISO
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of PLA2G7 mRNA]
CTD
PMID:18089841
NCBI chr 9:24,859,491...24,901,747
Ensembl chr 9:24,859,502...24,901,747
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Rnasel
ribonuclease L
multiple interactions
ISO
Doxycycline promotes the reaction [erastin results in increased expression of RNASEL mRNA]
CTD
PMID:38115220
NCBI chr13:68,446,641...68,460,804
Ensembl chr13:68,446,882...68,459,557
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Rnf38
ring finger protein 38
multiple interactions
ISO
[Doxycycline co-treated with erastin] results in increased expression of RNF38 mRNA
CTD
PMID:38115220
NCBI chr 5:63,154,507...63,263,138
Ensembl chr 5:63,154,507...63,263,137
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S100a8
S100 calcium binding protein A8
multiple interactions
ISO
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of S100A8 mRNA]
CTD
PMID:18089841
NCBI chr 2:178,464,095...178,465,223
Ensembl chr 2:178,464,702...178,465,221
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S100a9
S100 calcium binding protein A9
multiple interactions
ISO
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of S100A9 mRNA]
CTD
PMID:18089841
NCBI chr 2:178,487,941...178,490,622
Ensembl chr 2:178,487,941...178,490,870
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S1pr1
sphingosine-1-phosphate receptor 1
multiple interactions
ISO
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of S1PR1 mRNA]; Doxycycline inhibits the reaction [Isoproterenol results in increased expression of S1PR1 protein]
CTD
PMID:18089841
NCBI chr 2:206,309,715...206,314,070
Ensembl chr 2:205,900,836...206,328,689
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Serpina3n
serpin family A member 3N
multiple interactions
ISO
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of SERPINA3N mRNA]
CTD
PMID:18089841
NCBI chr 6:129,088,392...129,095,950
Ensembl chr 6:129,088,398...129,097,415
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Slc10a1
solute carrier family 10 member 1
decreases expression
EXP
Doxycycline results in decreased expression of SLC10A1 mRNA
CTD
PMID:27765674
NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944
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Slc22a6
solute carrier family 22 member 6
multiple interactions
ISO
Doxycycline inhibits the reaction [SLC22A6 protein results in increased uptake of Anions]
CTD
PMID:11855680
NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311
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Slco1a1
solute carrier organic anion transporter family, member 1a1
decreases expression
EXP
Doxycycline results in decreased expression of SLCO1A1 mRNA
CTD
PMID:27765674
NCBI chr 4:176,606,924...176,682,027
Ensembl chr 4:176,607,687...176,681,992
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Slpi
secretory leukocyte peptidase inhibitor
multiple interactions
ISO
Doxycycline promotes the reaction [erastin results in increased expression of SLPI mRNA]
CTD
PMID:38115220
NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:173,501,573...173,503,822
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Smyd1
SET and MYND domain containing 1
multiple interactions
ISO
Doxycycline inhibits the reaction [Isoproterenol results in decreased expression of SMYD1 mRNA]
CTD
PMID:18089841
NCBI chr 4:104,757,281...104,811,307
Ensembl chr 4:104,760,475...104,870,081
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Socs3
suppressor of cytokine signaling 3
multiple interactions
ISO
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of SOCS3 mRNA]
CTD
PMID:18089841
NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825
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Sod1
superoxide dismutase 1
multiple interactions
ISO
Doxycycline inhibits the reaction [Doxorubicin results in decreased expression of SOD1 protein]
CTD
PMID:17673183
NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399
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Syn1
synapsin I
increases expression
EXP
Doxycycline results in increased expression of SYN1 protein
CTD
PMID:33798505
NCBI chr X:3,725,745...3,780,940
Ensembl chr X:3,725,714...3,780,938
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Tardbp
TAR DNA binding protein
multiple interactions decreases expression
ISO
[Doxycycline analog results in decreased expression of TARDBP protein] inhibits the reaction [sodium arsenite affects the localization of TARDBP protein]
CTD
PMID:24019256
NCBI chr 5:164,330,452...164,348,435
Ensembl chr 5:164,334,924...164,345,204
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Tgfbr2
transforming growth factor, beta receptor 2
multiple interactions
ISO
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of TGFBR2 mRNA]
CTD
PMID:18089841
NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:124,674,986...124,761,469
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Tnf
tumor necrosis factor
multiple interactions
ISO
Doxycycline inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of TNF protein]; Doxycycline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
CTD
PMID:16134060 PMID:25977597
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
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Tp53inp1
tumor protein p53 inducible nuclear protein 1
multiple interactions
ISO
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of TRP53INP1 mRNA]
CTD
PMID:18089841
NCBI chr 5:29,051,267...29,069,486
Ensembl chr 5:29,051,264...29,069,484
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Ccl2
C-C motif chemokine ligand 2
decreases expression
ISO
meclocycline results in decreased expression of CCL2 protein
CTD
PMID:20116850
NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
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Ccl3
C-C motif chemokine ligand 3
decreases expression
ISO
meclocycline results in decreased expression of CCL3 protein
CTD
PMID:20116850
NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439
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Ccl4
C-C motif chemokine ligand 4
decreases expression
ISO
meclocycline results in decreased expression of CCL4 protein
CTD
PMID:20116850
NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722
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Ccl5
C-C motif chemokine ligand 5
decreases expression
ISO
meclocycline results in decreased expression of CCL5 protein
CTD
PMID:20116850
NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884
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Il6r
interleukin 6 receptor
decreases expression
ISO
meclocycline results in decreased expression of IL6R protein modified form
CTD
PMID:20116850
NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221
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Vegfa
vascular endothelial growth factor A
decreases expression
ISO
meclocycline results in decreased expression of VEGFA protein
CTD
PMID:20116850
NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
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Aif1
allograft inflammatory factor 1
multiple interactions decreases expression
ISO
Minocycline affects the reaction [GPX1 protein affects the expression of AIF1 protein]; Minocycline inhibits the reaction [Methamphetamine results in increased expression of AIF1 protein]; Minocycline inhibits the reaction [Morphine results in increased expression of AIF1 protein] Minocycline results in decreased expression of AIF1 protein
CTD
PMID:32916201 PMID:36682417 PMID:37394652
NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,652,243...3,657,339
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Aifm1
apoptosis inducing factor, mitochondria associated 1
multiple interactions decreases secretion
EXP ISO
Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of and results in increased localization of AIFM1 protein] Minocycline results in decreased secretion of AIFM1 protein Minocycline inhibits the reaction [Kainic Acid results in increased localization of AIFM1 protein]
CTD
PMID:12930891 PMID:16469440
NCBI chr X:132,528,107...132,567,237
Ensembl chr X:132,528,107...132,567,237
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App
amyloid beta precursor protein
multiple interactions
ISO EXP
Minocycline inhibits the reaction [APP gene mutant form results in increased phosphorylation of EIF2S1 protein] Minocycline inhibits the reaction [APP protein alternative form results in increased activity of CASP12 protein]; Minocycline inhibits the reaction [APP protein alternative form results in increased phosphorylation of EIF2AK2 protein]; Minocycline inhibits the reaction [APP protein alternative form results in increased phosphorylation of EIF2S1 protein]
CTD
PMID:17406652
NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971
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Atf3
activating transcription factor 3
multiple interactions
EXP
Minocycline inhibits the reaction [Paclitaxel results in increased expression of ATF3 protein]
CTD
PMID:21050491
NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750
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Atf6
activating transcription factor 6
multiple interactions
EXP
Minocycline inhibits the reaction [Paraquat results in increased expression of ATF6 protein]
CTD
PMID:22245251
NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033
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Atp5f1a
ATP synthase F1 subunit alpha
multiple interactions
ISO
Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP5F1A protein]
CTD
PMID:23562983
NCBI chr18:73,567,537...73,575,473
Ensembl chr18:73,567,526...73,575,922
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Atp5pd
ATP synthase peripheral stalk subunit d
multiple interactions
EXP
Minocycline inhibits the reaction [cypermethrin results in decreased expression of ATP5PD protein]
CTD
PMID:21561882
NCBI chr10:101,156,673...101,161,926
Ensembl chr10:101,156,673...101,162,954
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Bace1
beta-secretase 1
multiple interactions
ISO
Minocycline inhibits the reaction [Copper results in increased expression of BACE1 mRNA]
CTD
PMID:18583042
NCBI chr 8:55,038,842...55,061,138
Ensembl chr 8:55,038,823...55,064,918
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Bak1
BCL2-antagonist/killer 1
multiple interactions
EXP
[Minocycline results in increased expression of BCL2 protein] which binds to BAK1 protein
CTD
PMID:15004018
NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions decreases expression
EXP ISO
[Minocycline results in increased expression of BCL2 protein] which binds to BAX protein; Minocycline inhibits the reaction [Sodium Azide affects the localization of BAX protein] Minocycline inhibits the reaction [Rotenone results in increased expression of BAX protein] Minocycline results in decreased expression of BAX protein
CTD
PMID:15004018 PMID:15172883 PMID:33402167
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
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Bcl2
BCL2, apoptosis regulator
multiple interactions increases expression
ISO EXP
[Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2 protein] results in increased expression of BCL2 mRNA; [Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of BCL2 protein Minocycline results in increased expression of BCL2 mRNA; Minocycline results in increased expression of BCL2 protein [Minocycline results in increased expression of BCL2 protein] which binds to BAK1 protein; [Minocycline results in increased expression of BCL2 protein] which binds to BAX protein; [Minocycline results in increased expression of BCL2 protein] which binds to BID protein; Sodium Azide inhibits the reaction [Minocycline results in increased expression of BCL2 protein]
CTD
PMID:15004018 PMID:19807907 PMID:20606027 PMID:20711699
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
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Bcl2l1
Bcl2-like 1
multiple interactions
ISO
Minocycline inhibits the reaction [Rotenone results in decreased expression of BCL2L1 protein]
CTD
PMID:33402167
NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907 Ensembl chr 1:161,745,540...161,764,907
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Bid
BH3 interacting domain death agonist
multiple interactions
ISO EXP
Minocycline results in decreased activity of and results in decreased cleavage of BID protein [Minocycline results in increased expression of BCL2 protein] which binds to BID protein; Minocycline inhibits the reaction [HTT protein mutant form results in increased cleavage of and results in increased activity of BID protein]
CTD
PMID:12930891 PMID:15004018
NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275
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Btg2
BTG anti-proliferation factor 2
multiple interactions
ISO
Minocycline inhibits the reaction [T-2 Toxin results in increased expression of BTG2 mRNA]; Minocycline inhibits the reaction [T-2 Toxin results in increased expression of BTG2 protein]
CTD
PMID:39147216
NCBI chr13:48,083,931...48,087,690
Ensembl chr13:48,083,931...48,087,690
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Casp1
caspase 1
multiple interactions decreases expression decreases activity
EXP ISO
Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP1 protein] Minocycline results in decreased expression of CASP1 mRNA; Minocycline results in decreased expression of CASP1 protein Minocycline results in decreased activity of CASP1 protein
CTD
PMID:12930891 PMID:14998631
NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275
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Casp12
caspase 12
multiple interactions decreases expression
EXP
Minocycline inhibits the reaction [APP protein alternative form results in increased activity of CASP12 protein]; Minocycline results in decreased degradation of [Paraquat results in increased expression of CASP12 protein] Minocycline results in decreased expression of CASP12 mRNA; Minocycline results in decreased expression of CASP12 protein
CTD
PMID:14998631 PMID:17406652 PMID:22245251
NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:10,926,994...10,954,442
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Casp3
caspase 3
decreases activity multiple interactions decreases expression
ISO EXP
Minocycline results in decreased activity of CASP3 protein Minocycline pretreatment inhibits the reaction [azide increases activity of Casp3 protein in kidney proximal tubular epithelial cells] Minocycline results in decreased expression of CASP3 mRNA Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP3 protein]; Minocycline inhibits the reaction [Morphine results in increased activity of CASP3 protein]; Minocycline inhibits the reaction [Paraquat results in increased cleavage of CASP3 protein]; Minocycline inhibits the reaction [sodium arsenite results in increased cleavage of CASP3 protein]; Minocycline inhibits the reaction [Sodium Azide results in increased activity of CASP3 protein]; Minocycline results in decreased expression of and results in decreased activity of CASP3 protein Minocycline inhibits the reaction [Kainic Acid results in increased activity of CASP3 protein]; Minocycline inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]; Minocycline inhibits the reaction [Rotenone results in increased cleavage of CASP3 protein]; Minocycline results in decreased activity of and results in decreased cleavage of CASP3 protein
CTD RGD
PMID:12930891 PMID:14588118 PMID:14998631 PMID:15004018 PMID:15304547 PMID:15564845 PMID:16469440 PMID:17872917 PMID:20711699 PMID:22245251 PMID:33402167 PMID:35939230 PMID:37394652 PMID:15004018 More...
RGD:1581919
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
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Casp7
caspase 7
decreases expression multiple interactions
EXP
Minocycline results in decreased expression of CASP7 mRNA Minocycline results in decreased expression of and results in decreased activity of CASP7 protein
CTD
PMID:14998631
NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512
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Casp8
caspase 8
multiple interactions decreases expression
EXP
Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP8 protein]; Minocycline inhibits the reaction [sodium arsenite results in increased cleavage of CASP8 protein]; Minocycline results in decreased expression of and results in decreased activity of CASP8 protein Minocycline results in decreased expression of CASP8 mRNA
CTD
PMID:12930891 PMID:14998631 PMID:35939230
NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699
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Casp9
caspase 9
decreases activity decreases expression multiple interactions
ISO EXP
Minocycline results in decreased activity of CASP9 protein Minocycline results in decreased expression of CASP9 mRNA Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP9 protein]; Minocycline results in decreased expression of and results in decreased activity of CASP9 protein
CTD
PMID:12930891 PMID:14998631
Ensembl chr 5:159,391,188...159,409,648
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Ccl2
C-C motif chemokine ligand 2
decreases expression multiple interactions
ISO
Minocycline results in decreased expression of CCL2 protein Minocycline inhibits the reaction [lead acetate results in increased secretion of CCL2 protein]
CTD
PMID:20116850 PMID:24530660
NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
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Ccl3
C-C motif chemokine ligand 3
decreases expression multiple interactions
ISO
Minocycline results in decreased expression of CCL3 protein Minocycline inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased secretion of CCL3 protein]
CTD
PMID:20116850 PMID:35351628
NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439
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Ccl4
C-C motif chemokine ligand 4
decreases expression
ISO
Minocycline results in decreased expression of CCL4 protein
CTD
PMID:20116850
NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722
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Ccl5
C-C motif chemokine ligand 5
decreases expression multiple interactions
ISO
Minocycline results in decreased expression of CCL5 protein Minocycline inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased secretion of CCL5 protein]
CTD
PMID:20116850 PMID:35351628
NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884
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Cd68
Cd68 molecule
multiple interactions
ISO
Minocycline affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CD68 protein]; Minocycline inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CD68 mRNA]
CTD
PMID:35351628
NCBI chr10:54,880,562...54,882,441
Ensembl chr10:54,880,563...54,882,540
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
increases expression
ISO
Minocycline results in increased expression of CDKN1B mRNA; Minocycline results in increased expression of CDKN1B protein
CTD
PMID:21719015
NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498
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Cldn5
claudin 5
increases expression
EXP
minocycline increases expression of claudin-5 protein in left corpus callosum of rats with right carotid artery occlusion
RGD
PMID:29486300
RGD:27095946
NCBI chr11:95,717,172...95,718,598
Ensembl chr11:95,717,176...95,719,322
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Cox5a
cytochrome c oxidase subunit 5A
multiple interactions
ISO
Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX5A protein]
CTD
PMID:23562983
NCBI chr 8:66,818,284...66,829,691
Ensembl chr 8:66,818,196...66,830,279
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Cycs
cytochrome c, somatic
multiple interactions decreases secretion
ISO EXP
Minocycline inhibits the reaction [Kainic Acid results in increased localization of CYCS protein] Minocycline results in decreased secretion of CYCS protein Minocycline inhibits the reaction [Cocaine results in increased secretion of CYCS protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of CYCS protein]
CTD
PMID:12930891 PMID:14998631 PMID:15172883 PMID:16469440 PMID:21424555
NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816 Ensembl chr18:80,982,668...80,984,816
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Ddit3
DNA-damage inducible transcript 3
multiple interactions
EXP
Minocycline inhibits the reaction [Paraquat results in increased expression of DDIT3 protein]
CTD
PMID:22245251
NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509
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Diablo
diablo, IAP-binding mitochondrial protein
decreases secretion multiple interactions
ISO EXP
Minocycline results in decreased secretion of DIABLO protein Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of DIABLO protein]; Minocycline results in decreased secretion of and results in decreased expression of DIABLO protein
CTD
PMID:12930891 PMID:14998631
NCBI chr12:38,716,668...38,731,285
Ensembl chr12:38,716,668...38,731,265
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Dlg1
discs large MAGUK scaffold protein 1
multiple interactions
ISO
Minocycline inhibits the reaction [Rotenone results in decreased expression of DLG1 protein]
CTD
PMID:33402167
NCBI chr11:82,416,853...82,607,797
Ensembl chr11:82,416,853...82,607,797
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Dlg4
discs large MAGUK scaffold protein 4
multiple interactions
ISO
Minocycline affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of DLG4 protein]
CTD
PMID:35351628
NCBI chr10:55,239,397...55,267,780
Ensembl chr10:55,236,869...55,265,839
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Dlst
dihydrolipoamide S-succinyltransferase
multiple interactions
ISO
Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DLST protein]
CTD
PMID:23562983
NCBI chr 6:110,489,576...110,512,841
Ensembl chr 6:110,489,392...110,514,357
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Egln1
egl-9 family hypoxia-inducible factor 1
multiple interactions increases expression
ISO
[[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] inhibits the reaction [Oxygen deficiency results in increased stability of HIF1A protein]; [[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] results in increased degradation of HIF1A protein
CTD
PMID:24292262
NCBI chr19:69,765,276...69,804,681
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Eif2ak2
eukaryotic translation initiation factor 2-alpha kinase 2
multiple interactions
EXP
Minocycline inhibits the reaction [APP protein alternative form results in increased phosphorylation of EIF2AK2 protein]
CTD
PMID:17406652
NCBI chr 6:21,941,147...21,977,115
Ensembl chr 6:21,952,631...21,977,116
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Eif2ak3
eukaryotic translation initiation factor 2 alpha kinase 3
increases phosphorylation
EXP
Minocycline results in increased phosphorylation of EIF2AK3 protein
CTD
PMID:22245251
NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268
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Eif2s1
eukaryotic translation initiation factor 2 subunit alpha
multiple interactions increases phosphorylation
ISO EXP
Minocycline inhibits the reaction [APP gene mutant form results in increased phosphorylation of EIF2S1 protein] Minocycline results in increased phosphorylation of EIF2S1 protein Minocycline inhibits the reaction [APP protein alternative form results in increased phosphorylation of EIF2S1 protein]
CTD
PMID:17406652 PMID:22245251
NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649
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Eno1
enolase 1
multiple interactions
ISO
Minocycline inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ENO1 protein]; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of ENO1 protein]
CTD
PMID:23562983
NCBI chr 5:166,002,867...166,014,252
Ensembl chr 3:77,946,261...77,986,003 Ensembl chr 5:77,946,261...77,986,003
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Ern1
endoplasmic reticulum to nucleus signaling 1
increases phosphorylation
EXP
Minocycline results in increased phosphorylation of ERN1 protein
CTD
PMID:22245251
NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791
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Fmr1
fragile X messenger ribonucleoprotein 1
multiple interactions
ISO
Minocycline inhibits the reaction [FMR1 gene mutant form results in increased expression of and results in increased activity of MMP9 protein]
CTD
PMID:18835858
NCBI chr X:152,284,857...152,322,686
Ensembl chr X:152,284,841...152,322,675
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Gfap
glial fibrillary acidic protein
multiple interactions
ISO
Minocycline inhibits the reaction [Rotenone results in increased expression of GFAP protein]
CTD
PMID:33402167
NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685
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Gjc2
gap junction protein, gamma 2
multiple interactions
EXP
Minocycline inhibits the reaction [cypermethrin results in increased expression of GJC2 protein modified form]
CTD
PMID:21561882
NCBI chr10:44,462,203...44,470,924
Ensembl chr10:44,462,054...44,470,340
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Gpx1
glutathione peroxidase 1
multiple interactions
ISO
Minocycline affects the reaction [GPX1 protein affects the expression of AIF1 protein]; Minocycline affects the reaction [GPX1 protein affects the phosphorylation of MAPK1 protein]; Minocycline affects the reaction [GPX1 protein affects the phosphorylation of MAPK3 protein]
CTD
PMID:36682417
NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581
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Gria1
glutamate ionotropic receptor AMPA type subunit 1
multiple interactions
EXP
Minocycline inhibits the reaction [Poly C results in increased expression of GRIA1 mRNA]
CTD
PMID:19660546
NCBI chr10:41,710,540...42,030,105
Ensembl chr10:41,711,080...42,030,309
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Grin2a
glutamate ionotropic receptor NMDA type subunit 2A
multiple interactions
EXP
Minocycline inhibits the reaction [Poly C results in increased expression of GRIN2A mRNA]
CTD
PMID:19660546
NCBI chr10:6,136,458...6,560,003
Ensembl chr10:6,138,037...6,551,378
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Grin2c
glutamate ionotropic receptor NMDA type subunit 2C
multiple interactions
EXP
Minocycline inhibits the reaction [Poly C results in increased expression of GRIN2C mRNA]
CTD
PMID:19660546
NCBI chr10:100,987,410...101,006,064
Ensembl chr10:100,987,513...101,005,409
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Gstp1
glutathione S-transferase pi 1
increases expression
EXP
minocycline increases expression of glutathione S-transferase pi protein in left corpus callosum of rats with right carotid artery occlusion
RGD
PMID:29486300
RGD:27095946
NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705
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Hif1a
hypoxia inducible factor 1 subunit alpha
multiple interactions increases degradation
ISO
[[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] inhibits the reaction [Oxygen deficiency results in increased stability of HIF1A protein]; [[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] results in increased degradation of HIF1A protein; Minocycline inhibits the reaction [Oxygen deficiency results in increased stability of HIF1A protein]; Minocycline promotes the reaction [HIF1A protein binds to VHL protein] Minocycline results in increased degradation of HIF1A protein
CTD
PMID:24292262
NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323
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Hp
haptoglobin
increases expression
EXP
minocycline increases expression of zonulin protein in left corpus callosum of rats with right carotid artery occlusion
RGD
PMID:29486300
RGD:27095946
NCBI chr19:54,449,151...54,453,701
Ensembl chr19:54,446,217...54,467,518
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Hspa5
heat shock protein family A (Hsp70) member 5
multiple interactions
EXP
Minocycline inhibits the reaction [Paraquat results in increased expression of HSPA5 protein]
CTD
PMID:22245251
NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790
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Hspd1
heat shock protein family D (Hsp60) member 1
multiple interactions
EXP
Minocycline inhibits the reaction [cypermethrin results in increased expression of HSPD1 protein]
CTD
PMID:21561882
NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037
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Htt
huntingtin
multiple interactions
EXP
Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP1 protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP3 protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP8 protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP9 protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased cleavage of and results in increased activity of BID protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of and results in increased localization of AIFM1 protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of CYCS protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of DIABLO protein]
CTD
PMID:12930891
NCBI chr14:80,070,456...80,219,668
Ensembl chr14:80,070,456...80,219,668
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Icam1
intercellular adhesion molecule 1
decreases expression
EXP
Minocycline results in decreased expression of ICAM1 protein
CTD
PMID:15172883
NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617
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Ifng
interferon gamma
multiple interactions
ISO
Minocycline inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG mRNA] [Minocycline co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA
CTD
PMID:19285099 PMID:29594315
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
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Il10
interleukin 10
multiple interactions increases expression
ISO EXP
Minocycline promotes the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA] Minocycline results in increased expression of IL10 mRNA
CTD
PMID:14588118 PMID:22024136
NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
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Il1b
interleukin 1 beta
multiple interactions affects secretion
ISO EXP
Minocycline inhibits the reaction [Cisplatin results in increased expression of IL1B mRNA]; Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; Minocycline inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Minocycline inhibits the reaction [Morphine results in increased expression of IL1B protein]; Minocycline inhibits the reaction [Paraquat results in increased expression of IL1B protein]; Minocycline inhibits the reaction [Rotenone results in increased expression of IL1B mRNA]; Minocycline inhibits the reaction [T-2 Toxin results in increased expression of IL1B mRNA] Minocycline inhibits the reaction [Kainic Acid results in increased secretion of IL1B protein]; Minocycline inhibits the reaction [lead acetate results in increased secretion of IL1B protein]; Minocycline inhibits the reaction [manganese chloride results in increased expression of IL1B protein]; Minocycline inhibits the reaction [Paclitaxel results in increased expression of IL1B protein]; Minocycline inhibits the reaction [Toluene results in increased expression of IL1B mRNA] Minocycline affects the secretion of IL1B protein
CTD
PMID:11306611 PMID:16386803 PMID:18836210 PMID:19285099 PMID:22024136 PMID:22952811 PMID:32234516 PMID:33402167 PMID:36775139 PMID:37394652 PMID:37769865 PMID:38189626 PMID:38459698 PMID:39147216 More...
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
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Il2
interleukin 2
multiple interactions
ISO
[Minocycline co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA
CTD
PMID:29594315
NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672
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Il6
interleukin 6
multiple interactions decreases expression
ISO EXP
Minocycline inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased secretion of IL6 protein]; Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of IL6 mRNA]; Minocycline inhibits the reaction [Dietary Fats results in increased expression of IL6 protein]; Minocycline inhibits the reaction [lead acetate results in increased secretion of IL6 protein]; Minocycline inhibits the reaction [Methamphetamine results in increased secretion of IL6 protein]; Minocycline inhibits the reaction [Morphine results in increased expression of IL6 protein]; Minocycline inhibits the reaction [Paraquat results in increased expression of IL6 protein]; Minocycline inhibits the reaction [T-2 Toxin results in increased expression of IL6 mRNA] minocycline inhibits the reaction [LPS increases expression of IL6 mRNA in hypothalamic microglia of alcohol fed neonates] minocycline inhibits the reaction [ethanol increases expression of IL6 mRNA and protein in hypothalamic microglia]
CTD RGD
PMID:19285099 PMID:21719015 PMID:24530660 PMID:32916201 PMID:35351628 PMID:36775139 PMID:37394652 PMID:38189626 PMID:39147216 PMID:30737481 PMID:30737481 More...
RGD:598092506 , RGD:598092506
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
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Il6r
interleukin 6 receptor
decreases expression
ISO
Minocycline results in decreased expression of IL6R protein modified form
CTD
PMID:20116850
NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221
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Ina
internexin neuronal intermediate filament protein, alpha
multiple interactions
EXP
Minocycline inhibits the reaction [cypermethrin results in increased expression of INA protein]
CTD
PMID:21561882
NCBI chr 1:255,838,129...255,849,680
Ensembl chr 1:255,838,129...255,849,680
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Itgam
integrin subunit alpha M
multiple interactions
ISO
Minocycline inhibits the reaction [Paraquat results in increased expression of ITGAM protein]; Minocycline inhibits the reaction [Paraquat results in increased phosphorylation of ITGAM protein]; Minocycline inhibits the reaction [T-2 Toxin results in increased expression of ITGAM protein]
CTD
PMID:36775139 PMID:38189626 PMID:39147216
NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
Minocycline results in decreased phosphorylation of and results in decreased activity of and results in decreased expression of JUN protein
CTD
PMID:17872917
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285
G
Mapk1
mitogen activated protein kinase 1
increases phosphorylation multiple interactions
ISO
Minocycline results in increased phosphorylation of MAPK1 protein Minocycline affects the reaction [GPX1 protein affects the phosphorylation of MAPK1 protein]
CTD
PMID:36682417
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
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Mapk3
mitogen activated protein kinase 3
multiple interactions increases phosphorylation
ISO
Minocycline affects the reaction [GPX1 protein affects the phosphorylation of MAPK3 protein] Minocycline results in increased phosphorylation of MAPK3 protein
CTD
PMID:36682417
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
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Mapk8
mitogen-activated protein kinase 8
decreases phosphorylation
ISO
Minocycline results in decreased phosphorylation of MAPK8 protein
CTD
PMID:17872917
NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427
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Mapkapk5
MAPK activated protein kinase 5
multiple interactions
EXP
Minocycline inhibits the reaction [cypermethrin results in increased expression of MAPKAPK5 protein]
CTD
PMID:21561882
NCBI chr12:40,654,220...40,673,740
Ensembl chr12:40,654,423...40,677,170
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Mlkl
mixed lineage kinase domain like pseudokinase
multiple interactions
EXP
Minocycline inhibits the reaction [Paclitaxel results in increased expression of MLKL protein]
CTD
PMID:38459698
NCBI chr19:56,186,860...56,213,886
Ensembl chr19:56,186,860...56,213,858
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Mmp13
matrix metallopeptidase 13
increases expression multiple interactions
ISO
Minocycline results in increased expression of MMP13 mRNA Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP13 mRNA]
CTD
PMID:19285099 PMID:20338993
NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105
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Mmp2
matrix metallopeptidase 2
decreases expression multiple interactions decreases activity
ISO EXP
Minocycline results in decreased expression of MMP2 protein Minocycline inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 mRNA] Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP2 mRNA]; Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP2 protein] Minocycline results in decreased activity of MMP2 protein
CTD
PMID:11835378 PMID:14508231 PMID:16846501 PMID:19285099 PMID:24292262
NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856
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Mmp3
matrix metallopeptidase 3
multiple interactions
ISO
Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP3 mRNA]
CTD
PMID:19285099
NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826
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Mmp9
matrix metallopeptidase 9
multiple interactions decreases activity decreases expression
ISO EXP
Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP9 mRNA]; Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP9 protein]; Minocycline inhibits the reaction [FMR1 gene mutant form results in increased expression of and results in increased activity of MMP9 protein] Minocycline results in decreased activity of MMP9 protein Minocycline results in decreased expression of MMP9 protein
CTD
PMID:16846501 PMID:18835858 PMID:19285099
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
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Mr1
major histocompatibility complex, class I-related
affects expression
ISO
Minocycline affects the expression of MR1 mRNA
CTD
PMID:25811541
NCBI chr13:69,850,420...69,868,302
Ensembl chr13:69,850,420...69,868,502
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Ncf1
neutrophil cytosolic factor 1
multiple interactions
ISO
Minocycline inhibits the reaction [Paraquat affects the localization of NCF1 protein]
CTD
PMID:38189626
NCBI chr12:28,121,816...28,131,080
Ensembl chr12:28,121,366...28,131,079
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Nlrp3
NLR family, pyrin domain containing 3
multiple interactions
ISO
Minocycline inhibits the reaction [Morphine results in increased expression of NLRP3 protein]
CTD
PMID:37394652
NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394
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Nos2
nitric oxide synthase 2
multiple interactions
ISO EXP
Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of NOS2 mRNA]; Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of NOS2 protein]; Minocycline inhibits the reaction [Morphine results in increased expression of NOS2 protein]; Minocycline inhibits the reaction [Paraquat results in increased expression of NOS2 protein]; Minocycline inhibits the reaction [Rotenone results in increased expression of NOS2 mRNA]; Minocycline inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA] Minocycline inhibits the reaction [lead acetate results in increased expression of NOS2 protein]; Minocycline inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Minocycline inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Minocycline inhibits the reaction [manganese chloride results in increased expression of NOS2 protein]
CTD
PMID:15485488 PMID:18836210 PMID:19285099 PMID:22952811 PMID:33402167 PMID:37394652 PMID:38189626 More...
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
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Ocln
occludin
increases expression
EXP
minocycline increases expression of occludin protein in left corpus callosum of rats with right carotid artery occlusion
RGD
PMID:29486300
RGD:27095946
NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411
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Pafah1b2
platelet-activating factor acetylhydrolase 1b, catalytic subunit 2
multiple interactions
EXP
Minocycline inhibits the reaction [cypermethrin results in decreased expression of PAFAH1B2 protein]
CTD
PMID:21561882
NCBI chr 8:55,156,778...55,208,800
Ensembl chr 8:55,156,779...55,176,836
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Pdk1
pyruvate dehydrogenase kinase 1
multiple interactions
ISO
Minocycline inhibits the reaction [Paraquat results in increased expression of PDK1 protein]
CTD
PMID:38189626
NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:77,113,473...77,144,145
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Pik3cb
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
multiple interactions
ISO
Minocycline inhibits the reaction [Paraquat results in increased expression of PIK3CB protein]
CTD
PMID:38189626
NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:108,474,019...108,579,331
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Prdx2
peroxiredoxin 2
multiple interactions
ISO
Minocycline inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PRDX2 protein]
CTD
PMID:23562983
NCBI chr19:40,085,788...40,091,083
Ensembl chr19:40,084,430...40,091,006
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Prdx3
peroxiredoxin 3
multiple interactions
ISO
Minocycline inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PRDX3 protein]; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PRDX3 protein]
CTD
PMID:23562983
NCBI chr 1:269,987,691...270,000,111
Ensembl chr 1:269,987,685...270,000,300
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Prkn
parkin RBR E3 ubiquitin protein ligase
multiple interactions
ISO
Minocycline inhibits the reaction [PRKN gene mutant form results in increased susceptibility to Rotenone]
CTD
PMID:16573651
NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:51,210,330...52,430,304
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Prtn3
proteinase 3
increases expression
ISO
Minocycline results in increased expression of PRTN3 protein
CTD
PMID:12900849
NCBI chr 7:10,472,750...10,482,037
Ensembl chr 7:10,472,755...10,482,474
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Ptgs1
prostaglandin-endoperoxide synthase 1
multiple interactions
EXP
Minocycline inhibits the reaction [Morphine results in increased expression of PTGS1 mRNA]
CTD
PMID:18706994
NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
Minocycline inhibits the reaction [Cisplatin results in increased expression of PTGS2 mRNA]; Minocycline inhibits the reaction [Morphine results in increased expression of PTGS2 protein]; Minocycline inhibits the reaction [T-2 Toxin results in increased expression of PTGS2 mRNA]; Minocycline inhibits the reaction [T-2 Toxin results in increased expression of PTGS2 protein]
CTD
PMID:36775139 PMID:37394652 PMID:37769865
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
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Pycard
PYD and CARD domain containing
multiple interactions
ISO
Minocycline inhibits the reaction [Morphine results in increased expression of PYCARD protein]
CTD
PMID:37394652
NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:192,032,124...192,033,419
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Rbfox3
RNA binding fox-1 homolog 3
multiple interactions
ISO
Minocycline inhibits the reaction [Paraquat results in decreased expression of RBFOX3 protein]; Minocycline inhibits the reaction [Rotenone results in decreased expression of RBFOX3 protein]
CTD
PMID:33402167 PMID:38189626
NCBI chr10:104,218,940...104,655,863
Ensembl chr10:104,218,940...104,551,945
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Rela
RELA proto-oncogene, NF-kB subunit
affects expression
ISO
Minocycline affects the expression of RELA protein
CTD
PMID:17898303
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
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Ripk3
receptor-interacting serine-threonine kinase 3
multiple interactions
EXP
Minocycline inhibits the reaction [Paclitaxel results in increased expression of RIPK3 protein]
CTD
PMID:38459698
NCBI chr15:33,253,071...33,262,025
Ensembl chr15:33,253,071...33,262,025
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RT1-CE16
RT1 class I, locus CE16
affects expression
ISO
Minocycline affects the expression of HLA-A mRNA
CTD
PMID:25811541
NCBI chr20:3,261,656...3,265,548
G
RT1-CE5
RT1 class I, locus CE5
affects expression
ISO
Minocycline affects the expression of HLA-F mRNA
CTD
PMID:25811541
NCBI chr20:3,407,880...3,484,130
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Slc22a6
solute carrier family 22 member 6
multiple interactions
ISO
Minocycline inhibits the reaction [SLC22A6 protein results in increased uptake of Anions]
CTD
PMID:11855680
NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311
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Slc22a7
solute carrier family 22 member 7
multiple interactions
ISO
Minocycline inhibits the reaction [SLC22A7 protein results in increased uptake of Anions]
CTD
PMID:11855680
NCBI chr 9:22,044,672...22,052,051
Ensembl chr 9:22,045,435...22,051,681
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Slc2a1
solute carrier family 2 member 1
multiple interactions
ISO
Minocycline inhibits the reaction [Oxygen deficiency results in increased expression of SLC2A1 mRNA]
CTD
PMID:24292262
NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742
G
Slc6a3
solute carrier family 6 member 3
multiple interactions
ISO
Minocycline inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]; Minocycline inhibits the reaction [Paraquat results in decreased expression of SLC6A3 protein]
CTD
PMID:16839653 PMID:38189626
NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:31,537,990...31,578,962
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Snap25
synaptosome associated protein 25
multiple interactions
EXP
Minocycline inhibits the reaction [cypermethrin results in decreased expression of SNAP25 protein]
CTD
PMID:21561882
NCBI chr 3:144,494,579...144,576,449
Ensembl chr 3:144,494,595...144,576,448
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Sod2
superoxide dismutase 2
multiple interactions
ISO
Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SOD2 protein]
CTD
PMID:23562983
NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
G
Stmn1
stathmin 1
multiple interactions
EXP ISO
Minocycline inhibits the reaction [cypermethrin results in decreased expression of STMN1 protein] Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STMN1 protein]
CTD
PMID:21561882 PMID:23562983
NCBI chr 5:151,964,308...151,970,843
Ensembl chr 5:151,964,351...151,970,842
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Tgfb1
transforming growth factor, beta 1
increases expression multiple interactions
EXP
Minocycline results in increased expression of TGFB1 mRNA Minocycline inhibits the reaction [Toluene results in decreased expression of TGFB1 mRNA]
CTD
PMID:32234516
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
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Tgfb2
transforming growth factor, beta 2
multiple interactions
ISO
[Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2 protein] results in increased expression of BCL2 mRNA; [Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of BCL2 protein; [Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of XIAP mRNA; [Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of XIAP protein
CTD
PMID:20606027
NCBI chr13:100,691,540...100,793,227
Ensembl chr13:100,692,953...100,792,856
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Th
tyrosine hydroxylase
multiple interactions
ISO
Minocycline inhibits the reaction [Paraquat results in decreased expression of TH protein]
CTD
PMID:38189626
NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227
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Tnf
tumor necrosis factor
multiple interactions decreases expression
EXP ISO
Minocycline inhibits the reaction [lead acetate results in increased secretion of TNF protein]; Minocycline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Minocycline inhibits the reaction [manganese chloride results in increased expression of TNF protein]; Minocycline inhibits the reaction [Paclitaxel results in increased expression of TNF protein] minocycline inhibits the reaction [LPS increases expression of TNFa mRNA in hypothalamic microglia of alcohol fed neonates] minocycline inhibits the reaction [ethanol increases expression of TNFa mRNA and protein in hypothalamic microglia] Minocycline inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased secretion of TNF protein]; Minocycline inhibits the reaction [Cisplatin results in increased expression of TNF mRNA]; Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of TNF mRNA]; Minocycline inhibits the reaction [Dietary Fats results in increased expression of TNF protein]; Minocycline inhibits the reaction [lead acetate results in increased secretion of TNF protein]; Minocycline inhibits the reaction [Methamphetamine results in increased secretion of TNF protein]; Minocycline inhibits the reaction [Morphine results in increased expression of TNF protein]; Minocycline inhibits the reaction [Paraquat results in increased expression of TNF protein]; Minocycline inhibits the reaction [Rotenone results in increased expression of TNF mRNA]; Minocycline inhibits the reaction [T-2 Toxin results in increased expression of TNF mRNA]; Minocycline inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA] Minocycline results in decreased expression of TNF mRNA
CTD RGD
PMID:14588118 PMID:15485488 PMID:18836210 PMID:19285099 PMID:21719015 PMID:22952811 PMID:24530660 PMID:32916201 PMID:33402167 PMID:35351628 PMID:36775139 PMID:37394652 PMID:37769865 PMID:38189626 PMID:38459698 PMID:39147216 PMID:30737481 PMID:30737481 More...
RGD:598092506 , RGD:598092506
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
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Tp53
tumor protein p53
decreases expression
EXP
Minocycline results in decreased expression of TP53 protein
CTD
PMID:15172883
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
G
Tpo
thyroid peroxidase
decreases activity
EXP
Minocycline results in decreased activity of TPO protein
CTD
PMID:26884060
NCBI chr 6:52,425,998...52,495,793
Ensembl chr 6:52,426,010...52,495,793
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Trem2
triggering receptor expressed on myeloid cells 2
multiple interactions
ISO
Minocycline inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TREM2 mRNA]
CTD
PMID:35351628
NCBI chr 9:20,145,215...20,151,797
Ensembl chr 9:20,144,334...20,151,779
G
Tuba1a
tubulin, alpha 1A
multiple interactions
ISO
Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TUBA1A protein]
CTD
PMID:23562983
NCBI chr 7:131,992,151...131,996,850
Ensembl chr 7:131,968,770...131,996,035
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Vegfa
vascular endothelial growth factor A
decreases expression
ISO
Minocycline results in decreased expression of VEGFA protein
CTD
PMID:20116850
NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
G
Vegfc
vascular endothelial growth factor C
multiple interactions
ISO
Minocycline inhibits the reaction [Oxygen deficiency results in increased expression of VEGFC mRNA]
CTD
PMID:24292262
NCBI chr16:44,445,293...44,560,887
Ensembl chr16:44,445,293...44,560,887
G
Vegfd
vascular endothelial growth factor D
multiple interactions
ISO
Minocycline inhibits the reaction [Oxygen deficiency results in increased expression of VEGFD mRNA]
CTD
PMID:24292262
NCBI chr X:33,704,582...33,740,305
Ensembl chr X:33,706,055...33,740,167
G
Vhl
von Hippel-Lindau tumor suppressor
multiple interactions
ISO
[[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] inhibits the reaction [Oxygen deficiency results in increased stability of HIF1A protein]; [[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] results in increased degradation of HIF1A protein; Minocycline promotes the reaction [HIF1A protein binds to VHL protein]
CTD
PMID:24292262
NCBI chr 4:148,328,099...148,334,992
Ensembl chr 4:148,328,079...148,334,991
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Xbp1
X-box binding protein 1
multiple interactions
EXP
Minocycline inhibits the reaction [Paraquat results in increased expression of XBP1 protein]
CTD
PMID:22245251
NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706
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Xiap
X-linked inhibitor of apoptosis
increases expression multiple interactions
EXP ISO
Minocycline results in increased expression of XIAP protein [Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of XIAP mRNA; [Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of XIAP protein
CTD
PMID:14998631 PMID:20606027
NCBI chr X:125,756,107...125,803,979
Ensembl chr X:125,737,971...125,803,978
G
Abcb1a
ATP binding cassette subfamily B member 1A
increases transport multiple interactions
ISO
ABCB1 protein results in increased transport of omadacycline [zosuquidar trihydrochloride results in decreased activity of ABCB1 protein] which results in decreased transport of omadacycline
CTD
PMID:27499331
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
G
Chrm2
cholinergic receptor, muscarinic 2
affects binding
ISO
omadacycline binds to CHRM2 protein
CTD
PMID:27324778
NCBI chr 4:65,981,136...66,116,128
Ensembl chr 4:65,981,006...66,126,464
G
Cat
catalase
decreases activity
ISO
Oxytetracycline results in decreased activity of CAT protein
CTD
PMID:29248593
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
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Ccl2
C-C motif chemokine ligand 2
decreases expression
ISO
Oxytetracycline results in decreased expression of CCL2 protein
CTD
PMID:20116850
NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
G
Ccl3
C-C motif chemokine ligand 3
decreases expression
ISO
Oxytetracycline results in decreased expression of CCL3 protein
CTD
PMID:20116850
NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439
G
Ccl4
C-C motif chemokine ligand 4
decreases expression
ISO
Oxytetracycline results in decreased expression of CCL4 protein
CTD
PMID:20116850
NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722
G
Ccl5
C-C motif chemokine ligand 5
decreases expression
ISO
Oxytetracycline results in decreased expression of CCL5 protein
CTD
PMID:20116850
NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884
G
Dio1
iodothyronine deiodinase 1
decreases activity
ISO
Oxytetracycline results in decreased activity of DIO1 protein
CTD
PMID:29228274
NCBI chr 5:127,303,089...127,319,784
Ensembl chr 5:127,303,083...127,319,771
G
Il6r
interleukin 6 receptor
decreases expression
ISO
Oxytetracycline results in decreased expression of IL6R protein modified form
CTD
PMID:20116850
NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221
G
Slc22a6
solute carrier family 22 member 6
multiple interactions
ISO
Oxytetracycline inhibits the reaction [SLC22A6 protein results in increased uptake of Anions]
CTD
PMID:11855680
NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311
G
Slc22a7
solute carrier family 22 member 7
multiple interactions
ISO
Oxytetracycline inhibits the reaction [SLC22A7 protein results in increased uptake of Anions]
CTD
PMID:11855680
NCBI chr 9:22,044,672...22,052,051
Ensembl chr 9:22,045,435...22,051,681
G
Vegfa
vascular endothelial growth factor A
decreases expression
ISO
Oxytetracycline results in decreased expression of VEGFA protein
CTD
PMID:20116850
NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
G
Aadac
arylacetamide deacetylase
decreases expression
ISO
Tetracycline results in decreased expression of AADAC mRNA
CTD
PMID:24489787
NCBI chr 2:146,293,449...146,351,061
Ensembl chr 2:146,313,279...146,324,525
G
Abca1
ATP binding cassette subfamily A member 1
increases expression
ISO
Tetracycline results in increased expression of ABCA1 mRNA
CTD
PMID:16917069
NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473
G
Abca8
ATP binding cassette subfamily A member 8
increases expression
ISO
Tetracycline results in increased expression of ABCA8B mRNA
CTD
PMID:16917069
NCBI chr10:95,416,984...95,490,647
Ensembl chr10:95,416,205...95,490,452
G
Abcb11
ATP binding cassette subfamily B member 11
decreases expression
EXP
Tetracycline results in decreased expression of ABCB11 mRNA
CTD
PMID:17522070 PMID:19224547 PMID:27765674
NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581
G
Abcb1a
ATP binding cassette subfamily B member 1A
increases expression
EXP
Tetracycline results in increased expression of ABCB1 mRNA
CTD
PMID:17522070 PMID:19224547
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
G
Abcb4
ATP binding cassette subfamily B member 4
decreases expression
ISO EXP
Tetracycline results in decreased expression of ABCB4 mRNA
CTD
PMID:24489787 PMID:27765674
NCBI chr 4:26,106,895...26,164,440
G
Abcc2
ATP binding cassette subfamily C member 2
decreases expression
EXP
Tetracycline results in decreased expression of ABCC2 mRNA
CTD
PMID:27765674
NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471
G
Abcc3
ATP binding cassette subfamily C member 3
increases expression
EXP
Tetracycline results in increased expression of ABCC3 mRNA
CTD
PMID:17522070 PMID:27765674
NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494
G
Abcc4
ATP binding cassette subfamily C member 4
increases transport increases expression
ISO EXP
ABCC4 protein results in increased transport of Tetracycline Tetracycline results in increased expression of ABCC4 mRNA
CTD
PMID:17939016 PMID:27765674
NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375
G
Abcd2
ATP binding cassette subfamily D member 2
decreases expression
ISO
Tetracycline results in decreased expression of ABCD2 mRNA
CTD
PMID:24489787
NCBI chr 7:124,142,597...124,191,202
Ensembl chr 7:124,142,595...124,191,202
G
Abcd3
ATP binding cassette subfamily D member 3
increases expression decreases expression
ISO
Tetracycline results in increased expression of ABCD3 mRNA Tetracycline results in decreased expression of ABCD3 mRNA
CTD
PMID:16917069 PMID:24489787
NCBI chr 2:212,536,791...212,590,379
Ensembl chr 2:212,536,791...212,590,504
G
Abcg2
ATP binding cassette subfamily G member 2
decreases expression
ISO
Tetracycline results in decreased expression of ABCG2 mRNA
CTD
PMID:24489787
NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493
G
Abcg5
ATP binding cassette subfamily G member 5
decreases expression
ISO EXP
Tetracycline results in decreased expression of ABCG5 mRNA
CTD
PMID:24489787 PMID:27765674
NCBI chr 6:15,717,936...15,743,376
Ensembl chr 6:15,717,936...15,743,376
G
Abcg8
ATP binding cassette subfamily G member 8
decreases expression
ISO
Tetracycline results in decreased expression of ABCG8 mRNA
CTD
PMID:24489787
NCBI chr 6:15,698,448...15,717,730
Ensembl chr 6:15,698,448...15,717,730
G
Acaca
acetyl-CoA carboxylase alpha
decreases expression
ISO
Tetracycline results in decreased expression of ACACA mRNA
CTD
PMID:24489787
NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888
G
Acadl
acyl-CoA dehydrogenase, long chain
multiple interactions decreases expression
ISO
bicyclol inhibits the reaction [Tetracycline results in decreased expression of ACADL mRNA]
CTD
PMID:19427351
NCBI chr 9:75,783,689...75,822,077
Ensembl chr 9:75,783,689...75,822,164
G
Acadm
acyl-CoA dehydrogenase medium chain
decreases expression
EXP
Tetracycline results in decreased expression of ACADM mRNA
CTD
PMID:17522070
NCBI chr 2:245,518,693...245,542,864
Ensembl chr 2:245,518,693...245,542,864
G
Acadsb
acyl-CoA dehydrogenase, short/branched chain
increases expression
ISO
Tetracycline results in increased expression of ACADSB mRNA
CTD
PMID:16917069
NCBI chr 1:195,619,088...195,660,564
Ensembl chr 1:195,619,038...195,660,561
G
Acadvl
acyl-CoA dehydrogenase, very long chain
decreases expression
ISO
Tetracycline results in decreased expression of ACADVL mRNA
CTD
PMID:24489787
NCBI chr10:55,231,558...55,236,786
Ensembl chr10:55,231,440...55,236,750
G
Acat1
acetyl-CoA acetyltransferase 1
decreases expression
ISO
Tetracycline results in decreased expression of ACAT1 mRNA
CTD
PMID:24489787
NCBI chr 8:62,876,003...62,905,080
Ensembl chr 8:62,876,003...62,905,042
G
Acat2
acetyl-CoA acetyltransferase 2
increases expression decreases expression
ISO
Tetracycline results in increased expression of ACAT2 mRNA Tetracycline results in decreased expression of ACAT2 mRNA
CTD
PMID:16917069 PMID:24489787
NCBI chr 1:50,100,840...50,118,886
Ensembl chr 1:50,100,817...50,135,095
G
Acbd5
acyl-CoA binding domain containing 5
increases expression
ISO
Tetracycline results in increased expression of ACBD5 mRNA
CTD
PMID:16917069
NCBI chr17:90,114,250...90,156,286
Ensembl chr17:90,114,375...90,156,286
G
Ace2
angiotensin converting enzyme 2
increases expression
ISO
Tetracycline results in increased expression of ACE2 mRNA
CTD
PMID:32808185
NCBI chr X:33,925,458...33,972,851
Ensembl chr X:33,925,458...33,971,596
G
Acly
ATP citrate lyase
decreases expression
EXP
Tetracycline results in decreased expression of ACLY mRNA
CTD
PMID:17522070
NCBI chr10:85,912,402...85,964,605
Ensembl chr10:85,912,402...85,963,631
G
Acox1
acyl-CoA oxidase 1
increases expression decreases expression
ISO
Tetracycline results in increased expression of ACOX1 mRNA Tetracycline results in decreased expression of ACOX1 mRNA
CTD
PMID:16917069 PMID:24489787
NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,905,083...101,930,136
G
Acox2
acyl-CoA oxidase 2
decreases expression
EXP ISO
Tetracycline results in decreased expression of ACOX2 mRNA
CTD
PMID:19224547 PMID:24489787
NCBI chr15:19,090,820...19,122,392
Ensembl chr15:19,090,926...19,122,392
G
Acsl1
acyl-CoA synthetase long-chain family member 1
increases expression decreases expression
ISO EXP
Tetracycline results in increased expression of ACSL1 mRNA Tetracycline results in decreased expression of ACSL1 mRNA
CTD
PMID:16917069 PMID:17522070 PMID:24489787
NCBI chr16:52,487,870...52,554,110
Ensembl chr16:52,487,870...52,554,023
G
Acsm1
acyl-CoA synthetase medium-chain family member 1
decreases expression
ISO
Tetracycline results in decreased expression of ACSM1 mRNA
CTD
PMID:24489787
NCBI chr 1:183,417,052...183,451,897
Ensembl chr 1:183,416,009...183,454,217
G
Acsm2
acyl-CoA synthetase medium-chain family member 2
increases expression
ISO
Tetracycline results in increased expression of ACSM2 mRNA
CTD
PMID:16917069
NCBI chr 1:183,347,705...183,386,453
Ensembl chr 1:183,347,705...183,386,453
G
Acsm3
acyl-CoA synthetase medium-chain family member 3
decreases expression
ISO
Tetracycline results in decreased expression of ACSM3 mRNA
CTD
PMID:24489787
NCBI chr 1:183,564,652...183,591,328
Ensembl chr 1:183,564,635...183,591,437
G
Acss2
acyl-CoA synthetase short-chain family member 2
decreases expression
ISO
Tetracycline results in decreased expression of ACSS2 mRNA
CTD
PMID:24489787
NCBI chr 3:164,464,124...164,507,607
Ensembl chr 3:164,464,055...164,519,830
G
Adipor2
adiponectin receptor 2
increases expression
ISO
Tetracycline results in increased expression of ADIPOR2 mRNA
CTD
PMID:16917069
NCBI chr 4:154,195,440...154,261,141
Ensembl chr 4:154,172,567...154,231,666
G
Agpat2
1-acylglycerol-3-phosphate O-acyltransferase 2
increases expression
ISO
Tetracycline results in increased expression of AGPAT2 mRNA
CTD
PMID:16917069
NCBI chr 3:29,814,924...29,826,569
Ensembl chr 3:29,814,924...29,826,581
G
Agpat4
1-acylglycerol-3-phosphate O-acyltransferase 4
decreases expression
ISO
Tetracycline results in decreased expression of AGPAT4 mRNA
CTD
PMID:16917069
NCBI chr 1:51,075,081...51,181,548
Ensembl chr 1:51,075,081...51,180,976
G
Agt
angiotensinogen
decreases expression
ISO
Tetracycline results in decreased expression of AGT mRNA
CTD
PMID:24489787
NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944
G
Ak3
adenylate kinase 3
decreases expression
ISO
Tetracycline results in decreased expression of AK3 mRNA
CTD
PMID:24489787
NCBI chr 1:236,151,012...236,178,689
Ensembl chr 1:236,151,012...236,178,183
G
Ak4
adenylate kinase 4
increases expression
EXP
Tetracycline results in increased expression of AK4 protein
CTD
PMID:16538043
NCBI chr 5:121,154,565...121,214,403
Ensembl chr 5:121,154,572...121,214,401
G
Akr1d1
aldo-keto reductase family 1, member D1
increases expression
ISO
Tetracycline results in increased expression of AKR1D1 mRNA
CTD
PMID:16917069
NCBI chr 4:67,121,288...67,154,543
Ensembl chr 4:67,120,024...67,154,540
G
Alas1
5'-aminolevulinate synthase 1
decreases expression
ISO
Tetracycline results in decreased expression of ALAS1 mRNA
CTD
PMID:24489787
NCBI chr 8:115,755,238...115,768,642
Ensembl chr 8:115,755,238...115,768,642
G
Aldh1a1
aldehyde dehydrogenase 1 family, member A1
decreases expression
ISO
Tetracycline results in decreased expression of ALDH1A1 mRNA
CTD
PMID:24489787
NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500
G
Aldh3a2
aldehyde dehydrogenase 3 family, member A2
decreases expression
EXP
Tetracycline results in decreased expression of ALDH3A2 mRNA
CTD
PMID:17522070
NCBI chr10:46,427,789...46,448,449
Ensembl chr10:46,407,993...46,448,648
G
Aldoa
aldolase, fructose-bisphosphate A
increases expression
EXP
Tetracycline results in increased expression of ALDOA mRNA
CTD
PMID:17522070
NCBI chr 1:190,832,820...190,838,021
Ensembl chr 1:190,832,820...190,838,211
G
Alox5ap
arachidonate 5-lipoxygenase activating protein
decreases expression
ISO
Tetracycline results in decreased expression of ALOX5AP mRNA
CTD
PMID:16917069
NCBI chr12:10,785,254...10,809,295
Ensembl chr12:10,785,257...10,817,038
G
Amacr
alpha-methylacyl-CoA racemase
decreases expression
ISO
Tetracycline results in decreased expression of AMACR mRNA
CTD
PMID:24489787
NCBI chr 2:61,673,291...61,685,381
Ensembl chr 2:61,670,475...61,685,379
G
Angptl3
angiopoietin-like 3
decreases expression
ISO
Tetracycline results in decreased expression of ANGPTL3 mRNA
CTD
PMID:24489787
NCBI chr 5:118,818,494...118,825,531
Ensembl chr 5:118,818,499...118,826,444
G
Aoah
acyloxyacyl hydrolase
increases expression
ISO
Tetracycline results in increased expression of AOAH mRNA
CTD
PMID:16917069
NCBI chr17:48,503,812...48,745,161
Ensembl chr17:48,503,812...48,745,146
G
Ap1s1
adaptor related protein complex 1 subunit sigma 1
decreases expression
ISO
Tetracycline results in decreased expression of AP1S1 mRNA
CTD
PMID:17175557
NCBI chr12:25,261,958...25,272,483
Ensembl chr12:25,262,036...25,272,483
G
Apex1
apurinic/apyrimidinic endodeoxyribonuclease 1
increases expression
EXP
Tetracycline results in increased expression of APEX1 mRNA
CTD
PMID:17522070
NCBI chr15:26,618,146...26,620,330
Ensembl chr15:26,618,224...26,620,329
G
Apob
apolipoprotein B
decreases expression
EXP
Tetracycline results in decreased expression of APOB mRNA
CTD
PMID:19224547
NCBI chr 6:36,563,704...36,603,300
Ensembl chr 6:36,563,704...36,611,814
G
Apoc1
apolipoprotein C1
decreases expression
ISO
Tetracycline results in decreased expression of APOC1 mRNA
CTD
PMID:16917069
NCBI chr 1:88,475,018...88,479,052
Ensembl chr 1:88,474,663...88,478,155
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Apoc2
apolipoprotein C2
decreases expression
ISO
Tetracycline results in decreased expression of APOC2 mRNA
CTD
PMID:16917069 PMID:24489787
NCBI chr 1:88,457,397...88,462,365
Ensembl chr 1:88,457,396...88,463,438
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Apoc3
apolipoprotein C3
decreases expression
ISO
Tetracycline results in decreased expression of APOC3 mRNA
CTD
PMID:16917069
NCBI chr 8:55,428,172...55,430,352
Ensembl chr 8:55,428,024...55,458,679
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Apof
apolipoprotein F
decreases expression
ISO
Tetracycline results in decreased expression of APOF mRNA
CTD
PMID:24489787
NCBI chr 7:1,285,222...1,286,659
Ensembl chr 7:1,285,222...1,286,659
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Ar
androgen receptor
decreases expression
ISO
Tetracycline results in decreased expression of AR mRNA
CTD
PMID:16917069
NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467
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Arnt
aryl hydrocarbon receptor nuclear translocator
increases expression
ISO
Tetracycline results in increased expression of ARNT mRNA
CTD
PMID:16917069
NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:185,680,683...185,745,546
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Arsa
arylsulfatase A
decreases expression
ISO
Tetracycline results in decreased expression of ARSA mRNA
CTD
PMID:16917069
NCBI chr 7:122,422,971...122,426,971
Ensembl chr 7:122,422,982...122,428,401
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Asgr2
asialoglycoprotein receptor 2
decreases expression
ISO
Tetracycline results in decreased expression of ASGR2 mRNA
CTD
PMID:24489787
NCBI chr10:55,320,082...55,333,294
Ensembl chr10:55,320,091...55,333,263
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Asl
argininosuccinate lyase
increases expression
EXP
Tetracycline results in increased expression of ASL mRNA
CTD
PMID:17522070
NCBI chr12:32,295,779...32,313,257
Ensembl chr12:32,295,633...32,317,261
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Asns
asparagine synthetase (glutamine-hydrolyzing)
increases expression
ISO
Tetracycline results in increased expression of ASNS mRNA
CTD
PMID:17175557
NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050
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Atp11a
ATPase phospholipid transporting 11A
decreases expression
ISO
Tetracycline results in decreased expression of ATP11A mRNA
CTD
PMID:16917069
NCBI chr16:83,359,884...83,469,807
Ensembl chr16:83,359,884...83,469,767
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Auh
AU RNA binding methylglutaconyl-CoA hydratase
increases expression
ISO
Tetracycline results in increased expression of AUH mRNA
CTD
PMID:16917069
NCBI chr17:12,481,396...12,576,748
Ensembl chr17:12,481,416...12,602,587
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Bbox1
gamma-butyrobetaine hydroxylase 1
decreases expression
ISO
Tetracycline results in decreased expression of BBOX1 mRNA
CTD
PMID:24489787
NCBI chr 3:117,277,226...117,326,383
Ensembl chr 3:117,277,226...117,326,064
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Bckdha
branched chain keto acid dehydrogenase E1 subunit alpha
increases expression
EXP
Tetracycline results in increased expression of BCKDHA protein
CTD
PMID:16538043
NCBI chr 1:90,266,731...90,295,521
Ensembl chr 1:90,261,629...90,295,749
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Bdh1
3-hydroxybutyrate dehydrogenase 1
decreases expression
ISO
Tetracycline results in decreased expression of BDH1 mRNA
CTD
PMID:24489787
NCBI chr11:82,806,125...82,848,133
Ensembl chr11:82,807,503...82,842,636
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Bscl2
BSCL2 lipid droplet biogenesis associated, seipin
decreases expression
ISO
Tetracycline results in decreased expression of BSCL2 mRNA
CTD
PMID:24489787
NCBI chr 1:215,160,764...215,172,540
Ensembl chr 1:215,160,957...215,172,536
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Btg2
BTG anti-proliferation factor 2
increases expression
EXP
Tetracycline results in increased expression of BTG2 mRNA
CTD
PMID:17522070
NCBI chr13:48,083,931...48,087,690
Ensembl chr13:48,083,931...48,087,690
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Ca3
carbonic anhydrase 3
increases expression
EXP
Tetracycline results in increased expression of CAR3 protein
CTD
PMID:16538043
NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:88,491,670...88,500,524
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Cacna2d1
calcium voltage-gated channel auxiliary subunit alpha2delta 1
increases expression
ISO
Tetracycline results in increased expression of CACNA2D1 mRNA
CTD
PMID:16917069
NCBI chr 4:19,902,324...20,330,287
Ensembl chr 4:19,905,764...20,330,147
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Calu
calumenin
increases expression
EXP
Tetracycline results in increased expression of CALU mRNA
CTD
PMID:17522070
NCBI chr 4:58,914,456...58,941,957
Ensembl chr 4:58,914,421...58,941,956
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Casp3
caspase 3
decreases expression
ISO
Tetracycline results in decreased expression of CASP3 mRNA
CTD
PMID:24489787
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
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Cat
catalase
increases expression decreases expression
ISO EXP
Tetracycline results in increased expression of CAT mRNA Tetracycline results in decreased expression of CAT mRNA
CTD
PMID:16917069 PMID:17522070
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
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Cbfa2t2
CBFA2/RUNX1 partner transcriptional co-repressor 2
increases expression
ISO
Tetracycline results in increased expression of CBFA2T2 mRNA
CTD
PMID:16917069
NCBI chr 3:163,397,160...163,503,409
Ensembl chr 3:163,397,185...163,503,407
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Cbs
cystathionine beta synthase
decreases expression
ISO
Tetracycline results in decreased expression of CBS mRNA
CTD
PMID:24489787
NCBI chr20:9,709,394...9,733,925
Ensembl chr20:9,709,395...9,734,066
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Ccn2
cellular communication network factor 2
increases expression
ISO
Tetracycline results in increased expression of CCN2 mRNA
CTD
PMID:16917069
NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976
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Ccnb3
cyclin B3
increases expression
ISO
Tetracycline results in increased expression of CCNB3 mRNA
CTD
PMID:16917069
NCBI chr X:18,149,915...18,214,801
Ensembl chr X:18,149,915...18,214,801
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Ccnd1
cyclin D1
decreases expression
EXP
Tetracycline results in decreased expression of CCND1 mRNA
CTD
PMID:19224547
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
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Ccng1
cyclin G1
increases expression
EXP
Tetracycline results in increased expression of CCNG1 mRNA
CTD
PMID:17522070
NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,677,885...25,683,766
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Cd36
CD36 molecule
multiple interactions increases expression
ISO
[Tetracycline results in increased expression of CD36 protein] which results in increased uptake of Fatty Acids Tetracycline results in increased expression of CD36 mRNA; Tetracycline results in increased expression of CD36 protein
CTD
PMID:25745068
NCBI chr 4:18,209,088...18,302,142
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Cers2
ceramide synthase 2
increases expression
ISO
Tetracycline results in increased expression of CERS2 mRNA
CTD
PMID:16917069
NCBI chr 2:185,579,511...185,587,789
Ensembl chr 2:185,579,119...185,588,839
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Cers5
ceramide synthase 5
increases expression
ISO
Tetracycline results in increased expression of CERS5 mRNA
CTD
PMID:16917069
NCBI chr 7:132,738,834...132,776,920
Ensembl chr 7:132,738,834...132,776,786
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Chka
choline kinase alpha
increases expression
ISO
Tetracycline results in increased expression of CHKA mRNA
CTD
PMID:16917069
NCBI chr 1:210,506,069...210,554,753
Ensembl chr 1:210,506,056...210,554,752
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Cideb
cell death-inducing DFFA-like effector b
decreases expression
ISO
Tetracycline results in decreased expression of CIDEB mRNA
CTD
PMID:24489787
NCBI chr15:33,222,135...33,226,407
Ensembl chr15:33,221,824...33,226,688
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Cldn10
claudin 10
decreases expression
ISO
Tetracycline results in decreased expression of CLDN10 mRNA
CTD
PMID:28882639
NCBI chr15:102,269,858...102,361,589
Ensembl chr15:102,269,858...102,361,589
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Cldn11
claudin 11
decreases expression
ISO
Tetracycline results in decreased expression of CLDN11 mRNA
CTD
PMID:28882639
NCBI chr 2:114,136,234...114,149,539
Ensembl chr 2:114,136,234...114,149,539
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Cldn15
claudin 15
decreases expression
ISO
Tetracycline results in decreased expression of CLDN15 mRNA
CTD
PMID:28882639
NCBI chr12:25,334,849...25,345,104
Ensembl chr12:25,334,849...25,343,477
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Cldn2
claudin 2
decreases expression
ISO
Tetracycline results in decreased expression of CLDN2 mRNA
CTD
PMID:28882639
NCBI chr X:108,248,383...108,258,847
Ensembl chr X:108,237,676...108,262,377
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Cldn6
claudin 6
decreases expression
ISO
Tetracycline results in decreased expression of CLDN6 mRNA
CTD
PMID:28882639
NCBI chr10:13,213,837...13,218,578
Ensembl chr10:13,213,956...13,218,581
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Cldn8
claudin 8
decreases expression
ISO
Tetracycline results in decreased expression of CLDN8 mRNA
CTD
PMID:28882639
NCBI chr11:41,362,081...41,364,330
G
Clu
clusterin
increases expression
EXP
Tetracycline results in increased expression of CLU mRNA
CTD
PMID:17522070
NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860
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Cox19
cytochrome c oxidase assembly factor COX19
decreases expression
ISO
Tetracycline results in decreased expression of COX19 mRNA
CTD
PMID:24489787
NCBI chr12:20,417,389...20,426,868
Ensembl chr12:20,417,341...20,426,868
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Cpt1a
carnitine palmitoyltransferase 1A
decreases expression
EXP ISO
Tetracycline results in decreased expression of CPT1A mRNA
CTD
PMID:19224547 PMID:24489787
NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326
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Crat
carnitine O-acetyltransferase
decreases expression
ISO
Tetracycline results in decreased expression of CRAT mRNA
CTD
PMID:16917069
NCBI chr 3:34,073,504...34,087,099
Ensembl chr 3:34,073,506...34,087,099
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Crot
carnitine O-octanoyltransferase
increases expression decreases expression
ISO
Tetracycline results in increased expression of CROT mRNA Tetracycline results in decreased expression of CROT mRNA
CTD
PMID:16917069 PMID:24489787
NCBI chr 4:26,031,729...26,088,057
Ensembl chr 4:26,052,516...26,088,064
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Cryab
crystallin, alpha B
decreases expression
ISO
Tetracycline results in decreased expression of CRYAB mRNA
CTD
PMID:24489787
NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:59,989,814...59,995,528
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Csf1
colony stimulating factor 1
increases expression
ISO
Tetracycline results in increased expression of CSF1 mRNA
CTD
PMID:16917069
NCBI chr 2:198,065,400...198,084,774
Ensembl chr 2:198,065,405...198,084,468
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Ctsl
cathepsin L
increases expression
EXP
Tetracycline results in increased expression of CTSL mRNA
CTD
PMID:17522070
NCBI chr17:770,104...776,266
Ensembl chr17:770,093...777,113
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Cxcl12
C-X-C motif chemokine ligand 12
decreases expression
ISO
Tetracycline results in decreased expression of CXCL12 mRNA
CTD
PMID:24489787
NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:152,060,780...152,073,627
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Cyb5a
cytochrome b5 type A
decreases expression
ISO
Tetracycline results in decreased expression of CYB5A mRNA
CTD
PMID:16917069
NCBI chr18:80,487,923...80,520,544
Ensembl chr18:14,453,966...14,455,094 Ensembl chr18:14,453,966...14,455,094
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Cyb5b
cytochrome b5 type B
increases expression
ISO
Tetracycline results in increased expression of CYB5B mRNA
CTD
PMID:16917069
NCBI chr19:51,972,611...52,006,477
Ensembl chr19:51,972,547...52,026,980
G
Cyb5r3
cytochrome b5 reductase 3
decreases expression
EXP
Tetracycline results in decreased expression of CYB5R3 mRNA
CTD
PMID:17522070
NCBI chr 7:116,186,729...116,204,290
Ensembl chr 7:116,186,729...116,204,306
G
Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
decreases expression
ISO
Tetracycline results in decreased expression of CYP17A1 mRNA
CTD
PMID:16917069
NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases expression
EXP
Tetracycline results in decreased expression of CYP1A1 mRNA
CTD
PMID:19224547
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012
G
Cyp26a1
cytochrome P450, family 26, subfamily a, polypeptide 1
decreases expression
ISO
Tetracycline results in decreased expression of CYP26A1 mRNA
CTD
PMID:16917069
NCBI chr 1:244,883,822...244,887,657
Ensembl chr 1:244,883,752...244,887,657
G
Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
decreases expression
ISO
Tetracycline results in decreased expression of CYP27A1 mRNA
CTD
PMID:24489787
NCBI chr 9:83,712,402...83,743,222
Ensembl chr 9:83,713,293...83,743,215
G
Cyp2a3
cytochrome P450, family 2, subfamily a, polypeptide 3
decreases expression
ISO
Tetracycline results in decreased expression of CYP2A4 mRNA
CTD
PMID:16917069
NCBI chr 1:91,299,584...91,307,650
Ensembl chr 1:91,299,561...91,307,649
G
Cyp2d3
cytochrome P450, family 2, subfamily d, polypeptide 3
decreases expression
EXP
Tetracycline results in decreased expression of CYP2D3 mRNA
CTD
PMID:17522070
NCBI chr 7:115,797,785...115,802,142
Ensembl chr 7:115,797,789...115,802,158
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions decreases expression
ISO
bicyclol inhibits the reaction [Tetracycline results in decreased expression of CYP2E1 mRNA]
CTD
PMID:19427351
NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495
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Cyp2j4
cytochrome P450, family 2, subfamily j, polypeptide 4
increases expression
ISO
Tetracycline results in increased expression of CYP2J9 mRNA
CTD
PMID:16917069
NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:116,295,694...116,323,042
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
decreases expression increases expression multiple interactions
EXP ISO
Tetracycline results in decreased expression of CYP3A4 mRNA Tetracycline results in increased expression of CYP3A4 mRNA Tetracycline results in increased expression of and results in increased activity of CYP3A4 protein
CTD
PMID:18505790 PMID:19224547
NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
G
Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
decreases expression
ISO
Tetracycline results in decreased expression of CYP46A1 mRNA
CTD
PMID:16917069
NCBI chr 6:133,011,948...133,039,167
Ensembl chr 6:133,011,989...133,041,971
G
Cyp4a1
cytochrome P450, family 4, subfamily a, polypeptide 1
increases expression decreases expression
EXP
Tetracycline results in increased expression of CYP4A1 mRNA Tetracycline results in decreased expression of CYP4A22 mRNA
CTD
PMID:12883083 PMID:19224547
NCBI chr 5:134,360,096...134,374,233
Ensembl chr 5:134,360,111...134,374,231
G
Cyp4f1
cytochrome P450, family 4, subfamily f, polypeptide 1
increases expression
ISO
Tetracycline results in increased expression of CYP4F14 mRNA
CTD
PMID:16917069
NCBI chr 7:12,661,357...12,672,952
Ensembl chr 7:12,661,359...12,672,612
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Cyp4f18
cytochrome P450, family 4, subfamily f, polypeptide 18
increases expression
ISO
Tetracycline results in increased expression of CYP4F18 mRNA
CTD
PMID:16917069
NCBI chr16:17,797,558...17,838,958
Ensembl chr16:17,740,001...17,838,958
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Cyp51
cytochrome P450, family 51
increases expression
ISO
Tetracycline results in increased expression of CYP51 mRNA
CTD
PMID:16917069
NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,991,613...31,010,450
G
Cyp7a1
cytochrome P450 family 7 subfamily A member 1
increases expression decreases expression
ISO EXP
Tetracycline results in increased expression of CYP7A1 mRNA Tetracycline results in decreased expression of CYP7A1 mRNA
CTD
PMID:16917069 PMID:19224547
NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202
G
Cyp7b1
cytochrome P450 family 7 subfamily B member 1
decreases expression
ISO
Tetracycline results in decreased expression of CYP7B1 mRNA
CTD
PMID:24489787
NCBI chr 2:102,419,011...102,586,047
Ensembl chr 2:102,419,011...102,451,804
G
Cyp8b1
cytochrome P450 family 8 subfamily B member 1
increases expression decreases expression
ISO
Tetracycline results in increased expression of CYP8B1 mRNA Tetracycline results in decreased expression of CYP8B1 mRNA
CTD
PMID:16917069 PMID:24489787
NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:130,442,503...130,457,689
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Dbi
diazepam binding inhibitor
decreases expression
ISO
Tetracycline results in decreased expression of DBI mRNA
CTD
PMID:16917069
NCBI chr13:33,794,231...33,802,632
Ensembl chr13:33,759,845...33,821,450
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Ddc
dopa decarboxylase
decreases expression
ISO
Tetracycline results in decreased expression of DDC mRNA
CTD
PMID:24489787
NCBI chr14:90,592,304...90,682,830
Ensembl chr14:90,592,304...90,682,806
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Ddit3
DNA-damage inducible transcript 3
increases expression
EXP
Tetracycline results in increased expression of DDIT3 mRNA
CTD
PMID:12883083 PMID:17522070
NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509
G
Depp1
DEPP autophagy regulator 1
increases expression
ISO
Tetracycline results in increased expression of DEPP1 mRNA
CTD
PMID:17175557
NCBI chr 4:151,583,105...151,585,455
Ensembl chr 4:151,581,502...151,586,233
G
Dgat2
diacylglycerol O-acyltransferase 2
increases expression multiple interactions
ISO
Tetracycline results in increased expression of DGAT2 protein Tetracycline results in increased expression of DGAT2 mRNA; Tetracycline results in increased expression of DGAT2 protein Tetracycline promotes the reaction [DGAT2 protein results in increased chemical synthesis of Triglycerides]
CTD
PMID:25745068
NCBI chr 1:162,866,237...162,896,655
Ensembl chr 1:162,866,237...162,896,566
G
Dgka
diacylglycerol kinase, alpha
decreases expression
ISO
Tetracycline results in decreased expression of DGKA mRNA
CTD
PMID:16917069
NCBI chr 7:1,733,247...1,761,181
Ensembl chr 7:1,733,248...1,759,569
G
Dhx29
DExH-box helicase 29
increases expression
ISO
Tetracycline results in increased expression of DHX29 mRNA
CTD
PMID:16917069
NCBI chr 2:46,293,901...46,344,652
Ensembl chr 2:46,293,677...46,344,948
G
Dnajb8
DnaJ heat shock protein family (Hsp40) member B8
increases expression
ISO
Tetracycline results in increased expression of DNAJB8 mRNA
CTD
PMID:16917069
NCBI chr 4:122,239,209...122,242,277
Ensembl chr 4:122,227,595...122,247,526
G
Dpm1
dolichyl-phosphate mannosyltransferase subunit 1, catalytic
decreases expression
ISO
Tetracycline results in decreased expression of DPM1 mRNA
CTD
PMID:16917069
NCBI chr 3:177,338,855...177,358,398
Ensembl chr 3:177,338,855...177,358,412
G
Eci1
enoyl-CoA delta isomerase 1
decreases expression
ISO
Tetracycline results in decreased expression of ECI1 mRNA
CTD
PMID:16917069
NCBI chr10:13,961,250...13,974,595
Ensembl chr10:13,961,218...13,974,773
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Egfr
epidermal growth factor receptor
decreases expression
ISO
Tetracycline results in decreased expression of EGFR mRNA
CTD
PMID:24489787
NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358
G
Ehhadh
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
decreases expression
ISO
Tetracycline results in decreased expression of EHHADH mRNA
CTD
PMID:27089845
NCBI chr11:92,746,409...92,779,647
Ensembl chr11:92,746,420...92,779,662
G
Elovl2
ELOVL fatty acid elongase 2
decreases expression
ISO
Tetracycline results in decreased expression of ELOVL2 mRNA
CTD
PMID:24489787
NCBI chr17:23,750,350...23,790,601
Ensembl chr17:23,750,350...23,790,601
G
Elovl3
ELOVL fatty acid elongase 3
increases expression
ISO
Tetracycline results in increased expression of ELOVL3 mRNA
CTD
PMID:16917069
NCBI chr 1:254,938,731...254,942,559
Ensembl chr 1:254,938,731...254,942,559
G
Elovl5
ELOVL fatty acid elongase 5
increases expression
ISO
Tetracycline results in increased expression of ELOVL5 mRNA
CTD
PMID:16917069
NCBI chr 8:87,671,164...87,737,618
Ensembl chr 8:87,671,159...87,737,616
G
Elovl6
ELOVL fatty acid elongase 6
decreases expression increases expression
EXP ISO
Tetracycline results in decreased expression of ELOVL6 mRNA Tetracycline results in increased expression of ELOVL6 mRNA
CTD
PMID:16917069 PMID:19224547
NCBI chr 2:220,738,095...220,845,528
Ensembl chr 2:220,738,064...220,845,549
G
Endog
endonuclease G
decreases expression
ISO
Tetracycline results in decreased expression of ENDOG mRNA
CTD
PMID:24489787
NCBI chr 3:33,846,935...33,849,531
Ensembl chr 3:33,846,885...33,849,573
G
Ephx1
epoxide hydrolase 1
decreases expression
ISO
Tetracycline results in decreased expression of EPHX1 mRNA
CTD
PMID:24489787
NCBI chr13:95,246,079...95,275,852
Ensembl chr13:95,246,080...95,321,981
G
Ephx2
epoxide hydrolase 2
decreases expression
ISO
Tetracycline results in decreased expression of EPHX2 mRNA
CTD
PMID:24489787
NCBI chr15:44,465,447...44,503,157
Ensembl chr15:44,465,448...44,503,160
G
Ergic2
ERGIC and golgi 2
increases expression
ISO
Tetracycline results in increased expression of ERGIC2 mRNA
CTD
PMID:16917069
NCBI chr 4:182,822,225...182,858,392
Ensembl chr 4:182,822,225...182,854,490
G
Etfdh
electron transfer flavoprotein dehydrogenase
decreases expression
ISO
Tetracycline results in decreased expression of ETFDH mRNA
CTD
PMID:24489787
NCBI chr 2:167,038,707...167,060,758
Ensembl chr 2:167,025,823...167,060,770
G
Exosc10
exosome component 10
increases expression
ISO
Tetracycline results in increased expression of EXOSC10 mRNA
CTD
PMID:16917069
NCBI chr 5:164,278,414...164,302,067
Ensembl chr 5:164,278,440...164,302,067
G
Exosc9
exosome component 9
increases expression
ISO
Tetracycline results in increased expression of EXOSC9 mRNA
CTD
PMID:16917069
NCBI chr 2:121,344,154...121,355,110
Ensembl chr 2:121,344,175...121,374,232
G
F10
coagulation factor X
decreases expression
ISO
Tetracycline results in decreased expression of F10 mRNA
CTD
PMID:24489787
NCBI chr16:83,170,973...83,190,280
Ensembl chr16:83,170,977...83,190,280
G
Faah
fatty acid amide hydrolase
increases expression
ISO
Tetracycline results in increased expression of FAAH mRNA
CTD
PMID:16917069
NCBI chr 5:134,716,545...134,735,396
Ensembl chr 5:134,716,545...134,735,396
G
Fabp1
fatty acid binding protein 1
decreases expression
EXP ISO
Tetracycline results in decreased expression of FABP1 mRNA
CTD
PMID:16917069 PMID:17522070 PMID:19224547 PMID:24489787
NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:104,744,309...104,753,113
G
Fabp4
fatty acid binding protein 4
decreases expression
ISO
Tetracycline results in decreased expression of FABP4 mRNA
CTD
PMID:16917069
NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972
G
Fabp7
fatty acid binding protein 7
decreases expression
ISO
Tetracycline results in decreased expression of FABP7 mRNA
CTD
PMID:16917069
NCBI chr20:37,667,125...37,673,299
Ensembl chr20:37,669,601...37,675,907
G
Fads1
fatty acid desaturase 1
decreases expression
EXP
Tetracycline results in decreased expression of FADS1 mRNA
CTD
PMID:17522070
NCBI chr 1:216,252,605...216,267,618
Ensembl chr 1:216,252,602...216,267,615
G
Fas
Fas cell surface death receptor
decreases expression
ISO
Tetracycline results in decreased expression of FAS mRNA
CTD
PMID:24489787
NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104
G
Fasn
fatty acid synthase
decreases expression
EXP
Tetracycline results in decreased expression of FASN mRNA
CTD
PMID:17522070 PMID:19224547
NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583
G
Fdft1
farnesyl diphosphate farnesyl transferase 1
decreases expression
ISO
Tetracycline results in decreased expression of FDFT1 mRNA
CTD
PMID:24489787
NCBI chr15:41,588,114...41,616,168
Ensembl chr15:41,588,117...41,616,168
G
Fdx1
ferredoxin 1
decreases expression
ISO
Tetracycline results in decreased expression of FDX1 mRNA
CTD
PMID:16917069
NCBI chr 8:61,164,839...61,183,645
Ensembl chr 8:61,164,839...61,183,583
G
Fezf2
Fez family zinc finger 2
increases expression
ISO
Tetracycline results in increased expression of FEZF2 mRNA
CTD
PMID:16917069
NCBI chr15:15,199,045...15,207,982
Ensembl chr15:15,204,193...15,207,982
G
Fga
fibrinogen alpha chain
increases expression
EXP
Tetracycline results in increased expression of FGA mRNA
CTD
PMID:17522070
NCBI chr 2:170,672,169...170,679,572
Ensembl chr 2:170,672,012...170,679,577
G
Fgb
fibrinogen beta chain
increases expression
EXP
Tetracycline results in increased expression of FGB mRNA
CTD
PMID:17522070
NCBI chr 2:170,693,966...170,700,875
Ensembl chr 2:170,692,965...170,705,434
G
Fmo1
flavin containing dimethylaniline monoxygenase 1
decreases expression
EXP
Tetracycline results in decreased expression of FMO1 mRNA
CTD
PMID:17522070
NCBI chr13:77,715,405...77,747,666
Ensembl chr13:77,715,402...77,747,874
G
Fndc4
fibronectin type III domain containing 4
increases expression
ISO
Tetracycline results in increased expression of FNDC4 mRNA
CTD
PMID:17175557
NCBI chr 6:30,797,102...30,800,782
Ensembl chr 6:30,796,871...30,800,769
G
Foxa1
forkhead box A1
decreases expression
EXP
Tetracycline results in decreased expression of FOXA1 mRNA
CTD
PMID:24469900
NCBI chr 6:80,838,380...80,871,195
Ensembl chr 6:80,800,960...80,871,191
G
Fxyd7
FXYD domain-containing ion transport regulator 7
increases expression
ISO
Tetracycline results in increased expression of FXYD7 mRNA
CTD
PMID:16917069
NCBI chr 1:95,405,071...95,414,407
Ensembl chr 1:95,405,225...95,414,345
G
G6pc1
glucose-6-phosphatase catalytic subunit 1
decreases expression
ISO
Tetracycline results in decreased expression of G6PC1 mRNA
CTD
PMID:24489787
NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033
G
Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases expression
EXP
Tetracycline results in increased expression of GADD45A mRNA
CTD
PMID:17522070 PMID:19224547
NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807
G
Gata2
GATA binding protein 2
increases expression
ISO
Tetracycline results in increased expression of GATA2 mRNA
CTD
PMID:16917069
NCBI chr 4:122,211,501...122,225,058
Ensembl chr 4:122,211,829...122,225,055
G
Gba2
glucosylceramidase beta 2
increases expression
ISO
Tetracycline results in increased expression of GBA2 mRNA
CTD
PMID:16917069
NCBI chr 5:62,618,176...62,630,160
Ensembl chr 5:62,618,177...62,630,308
G
Gde1
glycerophosphodiester phosphodiesterase 1
decreases expression
ISO
Tetracycline results in decreased expression of GDE1 mRNA
CTD
PMID:16917069
NCBI chr 1:182,451,182...182,466,569
Ensembl chr 1:182,451,184...182,466,772
G
Gdpd1
glycerophosphodiester phosphodiesterase domain containing 1
decreases expression
ISO
Tetracycline results in decreased expression of GDPD1 mRNA
CTD
PMID:16917069
NCBI chr10:72,318,716...72,381,143
Ensembl chr10:72,337,778...72,381,120
G
Gga1
golgi associated, gamma adaptin ear containing, ARF binding protein 1
increases expression
ISO
Tetracycline results in increased expression of GGA1 mRNA
CTD
PMID:16917069
NCBI chr 7:112,316,530...112,332,249
Ensembl chr 7:112,315,449...112,332,249
G
Gja8
gap junction protein, alpha 8
decreases expression
ISO
Tetracycline results in decreased expression of GJA8 mRNA
CTD
PMID:28882639
NCBI chr 2:187,179,668...187,181,284
Ensembl chr 2:187,175,507...187,186,167
G
Gjd2
gap junction protein, delta 2
decreases expression
ISO
Tetracycline results in decreased expression of GJD2 mRNA
CTD
PMID:28882639
NCBI chr 3:121,226,372...121,229,367
Ensembl chr 3:121,226,368...121,230,603
G
Glud1
glutamate dehydrogenase 1
increases expression
EXP
Tetracycline results in increased expression of GLUD1 protein
CTD
PMID:16538043
NCBI chr16:9,646,569...9,680,215
Ensembl chr16:9,646,509...9,680,210
G
Glyat
glycine-N-acyltransferase
decreases expression
ISO
Tetracycline results in decreased expression of GLYAT mRNA
CTD
PMID:24489787
NCBI chr 1:219,128,798...219,149,615
Ensembl chr 1:219,128,811...219,150,774
G
Gmpr2
guanosine monophosphate reductase 2
increases expression
ISO
Tetracycline results in increased expression of GMPR2 mRNA
CTD
PMID:16917069
NCBI chr15:33,135,455...33,144,923
Ensembl chr15:33,135,682...33,144,899
G
Gpd1
glycerol-3-phosphate dehydrogenase 1
decreases expression
ISO
Tetracycline results in decreased expression of GPD1 mRNA
CTD
PMID:24489787
NCBI chr 7:132,722,982...132,730,373
Ensembl chr 7:132,721,915...132,730,368
G
Gpd2
glycerol-3-phosphate dehydrogenase 2
increases expression
ISO
Tetracycline results in increased expression of GPD2 mRNA
CTD
PMID:16917069
NCBI chr 3:62,209,432...62,346,590
Ensembl chr 3:62,210,814...62,346,593
G
Gpr151
G protein-coupled receptor 151
increases expression
ISO
Tetracycline results in increased expression of GPR151 mRNA
CTD
PMID:16917069
NCBI chr18:34,819,878...34,821,272
Ensembl chr18:34,819,878...34,821,272
G
Gpt2
glutamic--pyruvic transaminase 2
decreases expression
ISO
Tetracycline results in decreased expression of GPT2 mRNA
CTD
PMID:24489787
NCBI chr19:37,700,023...37,734,551
Ensembl chr19:37,691,901...37,733,917
G
Gpx1
glutathione peroxidase 1
decreases expression
EXP
Tetracycline results in decreased expression of GPX1 mRNA
CTD
PMID:17522070
NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581
G
Gpx3
glutathione peroxidase 3
decreases expression
ISO
Tetracycline results in decreased expression of GPX3 mRNA
CTD
PMID:16917069
NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,529,448...39,537,405
G
Gpx4
glutathione peroxidase 4
decreases expression
ISO
Tetracycline results in decreased expression of GPX4 mRNA
CTD
PMID:16917069
NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629
G
Gsta2
glutathione S-transferase alpha 2
decreases expression
EXP
Tetracycline results in decreased expression of GSTA2 mRNA
CTD
PMID:19224547
NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:88,064,616...88,077,092
G
Gstm5
glutathione S-transferase, mu 5
decreases activity decreases expression
ISO EXP
Tetracycline results in decreased activity of GSTM3 protein Tetracycline results in decreased expression of GSTM3 mRNA
CTD
PMID:11807801 PMID:17522070
NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:198,219,647...198,222,731
G
Gstp1
glutathione S-transferase pi 1
multiple interactions increases expression decreases activity
ISO EXP
Tetracycline inhibits the reaction [GSTP1 protein affects the metabolism of and results in decreased activity of Ethacrynic Acid] Tetracycline results in increased expression of GSTP2 mRNA Tetracycline results in decreased activity of GSTP1 protein
CTD
PMID:11807801 PMID:19224547
NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705
G
Gys2
glycogen synthase 2
decreases expression
EXP
Tetracycline results in decreased expression of GYS2 mRNA
CTD
PMID:19224547
NCBI chr 4:177,096,063...177,137,236
Ensembl chr 4:177,096,063...177,137,236
G
Hadh
hydroxyacyl-CoA dehydrogenase
decreases expression
ISO
Tetracycline results in decreased expression of HADH mRNA
CTD
PMID:24489787
NCBI chr 2:222,462,049...222,504,446
Ensembl chr 2:222,462,049...222,504,446
G
Hadha
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
increases expression decreases expression
ISO
Tetracycline results in increased expression of HADHA mRNA Tetracycline results in decreased expression of HADHA mRNA
CTD
PMID:16917069 PMID:24489787
NCBI chr 6:31,907,801...31,947,434
Ensembl chr 6:31,907,291...31,947,698
G
Hexb
hexosaminidase subunit beta
increases expression
ISO
Tetracycline results in increased expression of HEXB mRNA
CTD
PMID:16917069
NCBI chr 2:30,218,608...30,238,771
Ensembl chr 2:30,218,608...30,238,771
G
Hhex
hematopoietically expressed homeobox
decreases expression
EXP
Tetracycline results in decreased expression of HHEX mRNA
CTD
PMID:24469900
NCBI chr 1:244,602,945...244,608,532
Ensembl chr 1:244,602,825...244,608,604
G
Hibadh
3-hydroxyisobutyrate dehydrogenase
decreases expression
EXP
Tetracycline results in decreased expression of HIBADH mRNA
CTD
PMID:17522070
NCBI chr 4:82,979,759...83,077,819
Ensembl chr 4:82,979,765...83,111,242
G
Hjv
hemojuvelin BMP co-receptor
decreases expression
ISO
Tetracycline results in decreased expression of HJV mRNA
CTD
PMID:24489787
NCBI chr 2:186,754,801...186,758,708
Ensembl chr 2:186,754,811...186,758,867
G
Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
decreases expression
EXP
Tetracycline results in decreased expression of HMGCR mRNA
CTD
PMID:19224547
NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533
G
Hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1
increases expression
ISO
Tetracycline results in increased expression of HMGCS1 mRNA
CTD
PMID:16917069
NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802
G
Hmgcs2
3-hydroxy-3-methylglutaryl-CoA synthase 2
decreases expression
ISO
Tetracycline results in decreased expression of HMGCS2 mRNA
CTD
PMID:24489787
NCBI chr 2:188,564,348...188,590,872
Ensembl chr 2:188,547,767...188,592,242
G
Hmox1
heme oxygenase 1
increases expression
EXP
Tetracycline results in increased expression of HMOX1 mRNA
CTD
PMID:19224547
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
G
Hnf4a
hepatocyte nuclear factor 4, alpha
decreases expression
EXP ISO
Tetracycline results in decreased expression of HNF4A mRNA
CTD
PMID:24469900 PMID:24489787
NCBI chr 3:172,606,220...172,667,758
Ensembl chr 3:172,606,220...172,667,758
G
Hpgd
15-hydroxyprostaglandin dehydrogenase
decreases expression
ISO
Tetracycline results in decreased expression of HPGD mRNA
CTD
PMID:24489787
NCBI chr16:38,996,876...39,034,831
Ensembl chr16:38,996,876...39,034,831
G
Hpn
hepsin
decreases expression
EXP
Tetracycline results in decreased expression of HPN mRNA
CTD
PMID:19224547
NCBI chr 1:95,464,468...95,480,169
Ensembl chr 1:95,464,470...95,480,199
G
Hsd17b1
hydroxysteroid (17-beta) dehydrogenase 1
increases expression
ISO
Tetracycline results in increased expression of HSD17B1 mRNA
CTD
PMID:16917069
NCBI chr10:86,510,011...86,512,211
Ensembl chr10:86,510,011...86,512,210
G
Hsd17b2
hydroxysteroid (17-beta) dehydrogenase 2
increases expression
ISO
Tetracycline results in increased expression of HSD17B2 mRNA
CTD
PMID:16917069
NCBI chr19:62,662,320...62,733,944
Ensembl chr19:62,662,098...62,733,943
G
Hsd17b4
hydroxysteroid (17-beta) dehydrogenase 4
decreases expression
ISO
Tetracycline results in decreased expression of HSD17B4 mRNA
CTD
PMID:24489787
NCBI chr18:45,515,427...45,604,467
Ensembl chr18:45,515,373...45,604,467
G
Hsd3b7
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
increases expression
ISO
Tetracycline results in increased expression of HSD3B7 mRNA
CTD
PMID:16917069
NCBI chr 1:191,842,688...191,845,919
Ensembl chr 1:191,842,636...191,845,921
G
Hsf2
heat shock transcription factor 2
decreases expression
ISO
Tetracycline results in decreased expression of HSF2 mRNA
CTD
PMID:24489787
NCBI chr20:37,366,301...37,393,922
Ensembl chr20:37,366,279...37,401,022
G
Hsp90b1
heat shock protein 90 beta family member 1
increases expression
ISO
Tetracycline results in increased expression of HSP90B1 mRNA
CTD
PMID:16917069
NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:22,997,962...23,012,293
G
Hspa1a
heat shock protein family A (Hsp70) member 1A
increases expression
EXP
Tetracycline results in increased expression of HSPA1A mRNA
CTD
PMID:17522070
NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979
G
Hspd1
heat shock protein family D (Hsp60) member 1
increases expression
EXP
Tetracycline results in increased expression of HSPD1 protein
CTD
PMID:16538043
NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037
G
Icam1
intercellular adhesion molecule 1
increases expression
EXP
Tetracycline results in increased expression of ICAM1 mRNA
CTD
PMID:17522070
NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617
G
Idh1
isocitrate dehydrogenase (NADP(+)) 1
decreases expression
ISO
Tetracycline results in decreased expression of IDH1 mRNA
CTD
PMID:24489787
NCBI chr 9:74,027,887...74,057,442
Ensembl chr 9:74,027,892...74,049,555
G
Igfbp1
insulin-like growth factor binding protein 1
increases expression
EXP ISO
Tetracycline results in increased expression of IGFBP1 mRNA
CTD
PMID:17522070 PMID:27089845
NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344
G
Igfbp2
insulin-like growth factor binding protein 2
decreases expression
ISO
Tetracycline results in decreased expression of IGFBP2 mRNA
CTD
PMID:24489787
NCBI chr 9:81,864,811...81,892,179
Ensembl chr 9:81,864,783...81,892,171
G
Igfbp3
insulin-like growth factor binding protein 3
decreases expression
ISO
Tetracycline results in decreased expression of IGFBP3 mRNA
CTD
PMID:24489787
NCBI chr14:86,270,208...86,277,944
Ensembl chr14:86,270,208...86,277,944
G
Il1b
interleukin 1 beta
multiple interactions decreases expression
ISO
Tetracycline analog inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Tetracycline inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Tetracycline inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA] Tetracycline results in decreased expression of IL1B mRNA
CTD
PMID:17267227 PMID:24489787
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
G
Il6
interleukin 6
decreases expression
ISO
Tetracycline results in decreased expression of IL6 mRNA
CTD
PMID:24489787
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
G
Inhbe
inhibin subunit beta E
increases expression
ISO
Tetracycline results in increased expression of INHBE mRNA
CTD
PMID:17175557
NCBI chr 7:65,061,531...65,064,519
Ensembl chr 7:65,061,531...65,064,519
G
Inpp5f
inositol polyphosphate-5-phosphatase F
increases expression
ISO
Tetracycline results in increased expression of INPP5F mRNA
CTD
PMID:16917069
NCBI chr 1:192,620,891...192,700,681
Ensembl chr 1:192,620,891...192,700,681
G
Insig2
insulin induced gene 2
increases expression
ISO
Tetracycline results in increased expression of INSIG2 mRNA
CTD
PMID:16917069
NCBI chr13:35,025,160...35,052,937
Ensembl chr13:35,025,164...35,047,658
G
Isyna1
inositol-3-phosphate synthase 1
decreases expression
ISO
Tetracycline results in decreased expression of ISYNA1 mRNA
CTD
PMID:24489787
NCBI chr16:18,873,119...18,876,116
Ensembl chr16:18,873,121...18,875,955
G
Itga3
integrin subunit alpha 3
decreases expression
ISO
Tetracycline results in decreased expression of ITGA3 mRNA
CTD
PMID:28882639
NCBI chr10:80,486,998...80,522,548
Ensembl chr10:80,486,999...80,518,901
G
Itga5
integrin subunit alpha 5
increases expression
ISO
Tetracycline results in increased expression of ITGA5 mRNA
CTD
PMID:28882639
NCBI chr 7:136,358,097...136,381,305
Ensembl chr 7:136,358,097...136,381,305
G
Itgae
integrin subunit alpha E
increases expression
ISO
Tetracycline results in increased expression of ITGAE mRNA
CTD
PMID:16917069
NCBI chr10:58,203,331...58,262,606
Ensembl chr10:58,203,364...58,262,606
G
Itgal
integrin subunit alpha L
decreases expression
ISO
Tetracycline results in decreased expression of ITGAL mRNA
CTD
PMID:28882639
NCBI chr 1:191,348,424...191,386,228
Ensembl chr 1:191,348,542...191,386,225
G
Itgam
integrin subunit alpha M
decreases expression
ISO
Tetracycline results in decreased expression of ITGAM mRNA
CTD
PMID:28882639
NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943
G
Jag1
jagged canonical Notch ligand 1
increases expression
ISO
Tetracycline results in increased expression of JAG1 mRNA
CTD
PMID:16917069
NCBI chr 3:144,859,453...144,894,883
Ensembl chr 3:144,859,453...144,894,872
G
Jak1
Janus kinase 1
increases expression
ISO
Tetracycline results in increased expression of JAK1 mRNA
CTD
PMID:16917069
NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:120,896,046...120,996,758
G
Kera
keratocan
increases expression
ISO
Tetracycline results in increased expression of KERA mRNA
CTD
PMID:16917069
NCBI chr 7:34,284,100...34,291,555
Ensembl chr 7:34,284,100...34,291,555
G
Krt18
keratin 18
increases expression
EXP
Tetracycline results in increased expression of KRT18 mRNA
CTD
PMID:17522070
NCBI chr 7:135,036,168...135,039,844
Ensembl chr 7:135,035,982...135,039,848 Ensembl chr10:135,035,982...135,039,848
G
Krt8
keratin 8
increases expression
EXP
Tetracycline results in increased expression of KRT8 mRNA
CTD
PMID:17522070
NCBI chr 7:135,002,886...135,010,339
Ensembl chr 7:135,002,894...135,010,403
G
Lbp
lipopolysaccharide binding protein
increases expression
EXP
Tetracycline results in increased expression of LBP mRNA
CTD
PMID:17522070
NCBI chr 3:167,373,786...167,400,941
Ensembl chr 3:167,373,924...167,401,518
G
Lcat
lecithin cholesterol acyltransferase
decreases expression
ISO
Tetracycline results in decreased expression of LCAT mRNA
CTD
PMID:24489787
NCBI chr19:50,744,598...50,748,064
Ensembl chr19:50,744,601...50,748,081
G
Lgals3
galectin 3
increases expression
EXP
Tetracycline results in increased expression of LGALS3 mRNA
CTD
PMID:17522070
NCBI chr15:23,099,795...23,111,731
Ensembl chr15:23,086,841...23,111,737
G
Lipc
lipase C, hepatic type
decreases expression
EXP
Tetracycline results in decreased expression of LIPC mRNA
CTD
PMID:17522070
NCBI chr 8:80,390,470...80,516,463
Ensembl chr 8:80,390,471...80,516,285
G
Lpl
lipoprotein lipase
increases expression
EXP
Tetracycline results in increased expression of LPL mRNA
CTD
PMID:17522070
NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107
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Lrig3
leucine-rich repeats and immunoglobulin-like domains 3
increases expression
ISO
Tetracycline results in increased expression of LRIG3 mRNA
CTD
PMID:16917069
NCBI chr 7:63,701,724...63,751,898
Ensembl chr 7:63,701,778...63,752,261
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Lrp4
LDL receptor related protein 4
decreases expression
ISO
Tetracycline results in decreased expression of LRP4 mRNA
CTD
PMID:16917069
NCBI chr 3:97,885,373...97,939,366
Ensembl chr 3:97,885,400...97,939,370
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Lrrc4b
leucine rich repeat containing 4B
increases expression
ISO
Tetracycline results in increased expression of LRRC4B mRNA
CTD
PMID:16917069
NCBI chr 1:104,058,558...104,092,831
Ensembl chr 1:104,072,128...104,093,298
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Mal
mal, T-cell differentiation protein
increases expression
ISO
Tetracycline results in increased expression of MAL mRNA
CTD
PMID:16917069
NCBI chr 3:135,317,664...135,341,423
Ensembl chr 3:135,317,664...135,341,423
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Maob
monoamine oxidase B
decreases expression
EXP ISO
Tetracycline results in decreased expression of MAOB mRNA
CTD
PMID:17522070 PMID:24489787
NCBI chr X:8,490,405...8,594,065
Ensembl chr X:8,490,344...8,594,375
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Mapk1
mitogen activated protein kinase 1
decreases phosphorylation
ISO
Tetracycline results in decreased phosphorylation of MAPK1 protein
CTD
PMID:25745068
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
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Mapk3
mitogen activated protein kinase 3
decreases phosphorylation
ISO
Tetracycline results in decreased phosphorylation of MAPK3 protein
CTD
PMID:25745068
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
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Mat1a
methionine adenosyltransferase 1A
decreases expression
ISO
Tetracycline results in decreased expression of MAT1A mRNA
CTD
PMID:24489787
NCBI chr16:17,017,168...17,035,368
Ensembl chr16:17,016,030...17,035,367
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Mcph1
microcephalin 1
increases expression
ISO
Tetracycline results in increased expression of MCPH1 mRNA
CTD
PMID:16917069
NCBI chr16:77,724,251...77,926,773
Ensembl chr16:77,724,251...77,926,462
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Me1
malic enzyme 1
increases expression
EXP
Tetracycline results in increased expression of ME1 protein
CTD
PMID:16538043
NCBI chr 8:96,429,057...96,540,244
Ensembl chr 8:96,429,057...96,540,275
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Mgat2
alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
increases expression
ISO
Tetracycline results in increased expression of MGAT2 mRNA
CTD
PMID:16917069
NCBI chr 6:93,392,416...93,394,905
Ensembl chr 6:93,390,555...93,395,176
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Mipep
mitochondrial intermediate peptidase
decreases expression
ISO
Tetracycline results in decreased expression of MIPEP mRNA
CTD
PMID:24489787
NCBI chr15:39,102,301...39,227,915
Ensembl chr15:39,102,115...39,227,914
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Mir16-2
microRNA 16-2
increases expression
EXP
Tetracycline results in increased expression of MIR16-2 mRNA
CTD
PMID:17522070
NCBI chr 2:155,555,327...155,555,421
Ensembl chr 2:155,555,327...155,555,421
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Mmp13
matrix metallopeptidase 13
multiple interactions decreases activity
ISO
Tetracycline analog inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Tetracycline inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA] Tetracycline analog results in decreased activity of MMP13 protein
CTD
PMID:17267227
NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105
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Mmp2
matrix metallopeptidase 2
decreases activity
ISO
Tetracycline analog results in decreased activity of MMP2 protein
CTD
PMID:17267227
NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856
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Mmp3
matrix metallopeptidase 3
multiple interactions decreases expression decreases activity
ISO
Tetracycline inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA] Tetracycline results in decreased expression of MMP3 mRNA Tetracycline results in decreased activity of MMP3 protein
CTD
PMID:17267227 PMID:24489787
NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826
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Mmp8
matrix metallopeptidase 8
decreases activity
ISO
Tetracycline analog results in decreased activity of MMP8 protein
CTD
PMID:17267227
NCBI chr 8:13,008,873...13,018,729
Ensembl chr 8:13,008,890...13,018,729
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Mrps12
mitochondrial ribosomal protein S12
increases expression
ISO
Tetracycline results in increased expression of MRPS12 mRNA
CTD
PMID:16917069
NCBI chr 1:93,153,424...93,156,422
Ensembl chr 1:93,153,425...93,159,629
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Mtmr11
myotubularin related protein 11
increases expression
ISO
Tetracycline results in increased expression of MTMR11 mRNA
CTD
PMID:16917069
NCBI chr 2:186,410,851...186,421,024
Ensembl chr 2:186,412,291...186,421,026
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Mttp
microsomal triglyceride transfer protein
decreases expression
ISO
Tetracycline results in decreased expression of MTTP mRNA
CTD
PMID:24489787 PMID:27089845
NCBI chr 2:229,286,501...229,327,650
Ensembl chr 2:229,286,501...229,327,650
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Mug1
murinoglobulin 1
decreases expression
EXP
Tetracycline results in decreased expression of MUG1 mRNA
CTD
PMID:17522070
NCBI chr 4:156,748,351...156,802,132
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Myc
MYC proto-oncogene, bHLH transcription factor
decreases expression increases expression
EXP
Tetracycline results in decreased expression of MYC mRNA Tetracycline results in increased expression of MYC mRNA
CTD
PMID:17202758 PMID:17522070
NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028
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Ndrg2
NDRG family member 2
decreases expression
EXP
Tetracycline results in decreased expression of NDRG2 protein
CTD
PMID:16538043
NCBI chr15:27,074,481...27,087,376
Ensembl chr15:27,074,481...27,083,125
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Nefh
neurofilament heavy chain
affects expression
EXP
Tetracycline affects the expression of NEFH mRNA
CTD
PMID:22954530
NCBI chr14:84,044,428...84,054,413
Ensembl chr14:84,044,023...84,054,417
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Neu3
neuraminidase 3
increases expression
ISO
Tetracycline results in increased expression of NEU3 mRNA
CTD
PMID:16917069
NCBI chr 1:163,549,834...163,560,997
Ensembl chr 1:163,549,738...163,561,049
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Nfkbib
NFKB inhibitor beta
increases expression
EXP
Tetracycline results in increased expression of NFKBIB mRNA
CTD
PMID:17522070
NCBI chr 1:93,173,817...93,181,387
Ensembl chr 1:93,173,820...93,326,366
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Notch3
notch receptor 3
decreases expression
ISO
Tetracycline results in decreased expression of NOTCH3 mRNA
CTD
PMID:28882639
NCBI chr 7:11,783,550...11,834,585
Ensembl chr 7:11,784,272...11,834,778
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Notch4
notch receptor 4
decreases expression
ISO
Tetracycline results in decreased expression of NOTCH4 mRNA
CTD
PMID:28882639
NCBI chr20:4,164,969...4,189,072
Ensembl chr20:4,161,730...4,189,072
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Nox4
NADPH oxidase 4
decreases expression
ISO
Tetracycline results in decreased expression of NOX4 mRNA
CTD
PMID:24489787
NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483
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Npm2
nucleophosmin/nucleoplasmin 2
increases expression
ISO
Tetracycline results in increased expression of NPM2 mRNA
CTD
PMID:16917069
NCBI chr15:52,131,973...52,145,710
Ensembl chr15:52,132,058...52,139,027
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Nqo1
NAD(P)H quinone dehydrogenase 1
decreases expression
EXP ISO
Tetracycline results in decreased expression of NQO1 mRNA
CTD
PMID:19224547 PMID:24489787
NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
decreases expression
ISO
Tetracycline results in decreased expression of NR1H4 mRNA
CTD
PMID:24489787
NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389
G
Nr1i3
nuclear receptor subfamily 1, group I, member 3
decreases expression
ISO
Tetracycline results in decreased expression of NR1I3 mRNA
CTD
PMID:24489787
NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370
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Nr2e3
nuclear receptor subfamily 2, group E, member 3
increases expression
ISO
Tetracycline results in increased expression of NR2E3 mRNA
CTD
PMID:16917069
NCBI chr 8:69,261,343...69,269,081
Ensembl chr 8:69,261,343...69,269,081
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Nsdhl
NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL
increases expression
ISO
Tetracycline results in increased expression of NSDHL mRNA
CTD
PMID:16917069
NCBI chr X:155,817,301...155,848,224
Ensembl chr X:155,817,340...155,848,220
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Nupr1
nuclear protein 1, transcriptional regulator
increases expression
ISO
Tetracycline results in increased expression of NUPR1 mRNA
CTD
PMID:17175557
NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:190,643,867...190,645,901
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Odc1
ornithine decarboxylase 1
increases expression
EXP
Tetracycline results in increased expression of ODC1 mRNA
CTD
PMID:17522070
NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:46,058,463...46,065,146
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Onecut1
one cut homeobox 1
decreases expression
ISO
Tetracycline results in decreased expression of ONECUT1 mRNA
CTD
PMID:24489787
NCBI chr 8:84,480,066...84,507,848
Ensembl chr 8:84,480,305...84,508,124
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Osbpl3
oxysterol binding protein-like 3
decreases expression
ISO
Tetracycline results in decreased expression of OSBPL3 mRNA
CTD
PMID:16917069
NCBI chr 4:80,677,383...80,854,169
Ensembl chr 4:80,677,390...80,854,169
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Osbpl8
oxysterol binding protein-like 8
decreases expression
ISO
Tetracycline results in decreased expression of OSBPL8 mRNA
CTD
PMID:16917069
NCBI chr 7:48,483,259...48,636,151
Ensembl chr 7:48,483,022...48,636,151
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Otc
ornithine transcarbamylase
decreases expression
EXP ISO
Tetracycline results in decreased expression of OTC mRNA
CTD
PMID:17522070 PMID:24489787
NCBI chr X:15,126,358...15,202,473
Ensembl chr X:15,126,358...15,239,555
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Pah
phenylalanine hydroxylase
decreases expression
ISO
Tetracycline results in decreased expression of PAH mRNA
CTD
PMID:24489787
NCBI chr 7:23,793,096...23,885,631
Ensembl chr 7:23,792,781...23,885,627
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Pak2
p21 (RAC1) activated kinase 2
increases expression
ISO
Tetracycline results in increased expression of PAK2 mRNA
CTD
PMID:16917069
NCBI chr11:82,212,896...82,273,803
Ensembl chr11:82,212,951...82,273,803
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Paqr7
progestin and adipoQ receptor family member 7
decreases expression
ISO
Tetracycline results in decreased expression of PAQR7 mRNA
CTD
PMID:16917069
NCBI chr 5:151,992,849...152,004,267
Ensembl chr 5:151,992,801...152,006,167
G
Paqr9
progestin and adipoQ receptor family member 9
increases expression
ISO
Tetracycline results in increased expression of PAQR9 mRNA
CTD
PMID:16917069
NCBI chr 8:104,993,884...104,996,180
Ensembl chr 8:104,993,827...104,998,285
G
Pc
pyruvate carboxylase
increases expression
ISO
Tetracycline results in increased expression of PCX mRNA
CTD
PMID:16917069
NCBI chr 1:211,228,708...211,327,792
Ensembl chr 1:211,228,731...211,329,940
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Pcdh18
protocadherin 18
increases expression
ISO
Tetracycline results in increased expression of PCDH18 mRNA
CTD
PMID:16917069
NCBI chr 2:135,982,929...135,996,917
Ensembl chr 2:135,983,144...135,996,826
G
Pck1
phosphoenolpyruvate carboxykinase 1
decreases expression
ISO
Tetracycline results in decreased expression of PCK1 mRNA
CTD
PMID:24489787
NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561
G
Pctp
phosphatidylcholine transfer protein
decreases expression
ISO
Tetracycline results in decreased expression of PCTP mRNA
CTD
PMID:16917069
NCBI chr10:75,305,999...75,351,919
Ensembl chr10:75,305,999...75,326,432
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Pde4b
phosphodiesterase 4B
increases expression
ISO
Tetracycline results in increased expression of PDE4B mRNA
CTD
PMID:16917069
NCBI chr 5:122,028,956...122,598,267
Ensembl chr 5:122,135,174...122,598,267
G
Pecr
peroxisomal trans-2-enoyl-CoA reductase
increases expression
ISO
Tetracycline results in increased expression of PECR mRNA
CTD
PMID:16917069
NCBI chr 9:81,347,170...81,375,809
Ensembl chr 9:81,347,173...81,375,806
G
Pi4kb
phosphatidylinositol 4-kinase beta
increases expression
ISO
Tetracycline results in increased expression of PI4KB mRNA
CTD
PMID:16917069
NCBI chr 2:185,229,392...185,261,697
Ensembl chr 2:185,228,799...185,261,693
G
Pik3c2a
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
increases expression
ISO
Tetracycline results in increased expression of PIK3C2A mRNA
CTD
PMID:16917069
NCBI chr 1:180,012,248...180,117,786
Ensembl chr 1:180,012,248...180,117,773
G
Pik3c2g
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
increases expression
ISO
Tetracycline results in increased expression of PIK3C2G mRNA
CTD
PMID:16917069
NCBI chr 4:174,215,527...174,583,378
Ensembl chr 4:174,215,527...174,581,705
G
Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
increases expression
ISO
Tetracycline results in increased expression of PIK3CA mRNA
CTD
PMID:16917069
NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411
G
Pik3cb
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
increases expression
ISO
Tetracycline results in increased expression of PIK3CB mRNA
CTD
PMID:16917069
NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:108,474,019...108,579,331
G
Pik3cd
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
decreases expression
ISO
Tetracycline results in decreased expression of PIK3CD mRNA
CTD
PMID:16917069
NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:165,377,994...165,403,968
G
Pip4k2b
phosphatidylinositol-5-phosphate 4-kinase type 2 beta
decreases expression
ISO
Tetracycline results in decreased expression of PIP4K2B mRNA
CTD
PMID:16917069
NCBI chr10:83,202,379...83,231,292
Ensembl chr10:83,197,287...83,231,292
G
Pip5k1a
phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha
increases expression
ISO
Tetracycline results in increased expression of PIP5K1A mRNA
CTD
PMID:16917069
NCBI chr 2:185,317,319...185,361,859
Ensembl chr 2:185,317,319...185,360,476
G
Pip5k1b
phosphatidylinositol-4-phosphate 5-kinase type 1 beta
increases expression
ISO
Tetracycline results in increased expression of PIP5K1B mRNA
CTD
PMID:16917069
NCBI chr 1:231,331,836...231,610,092
Ensembl chr 1:231,340,606...231,496,812
G
Pitpna
phosphatidylinositol transfer protein, alpha
increases expression
ISO
Tetracycline results in increased expression of PITPNA mRNA
CTD
PMID:16917069
NCBI chr10:60,929,050...60,969,614
Ensembl chr10:60,929,007...60,971,830
G
Pkd1l3
polycystin 1 like 3, transient receptor potential channel interacting
increases expression
ISO
Tetracycline results in increased expression of PKD1L3 mRNA
CTD
PMID:16917069
NCBI chr19:54,494,529...54,559,596
Ensembl chr19:54,495,243...54,559,546
G
Pklr
pyruvate kinase L/R
decreases expression
EXP
Tetracycline results in decreased expression of PKLR mRNA
CTD
PMID:17522070 PMID:19224547
NCBI chr 2:176,840,779...176,849,637
Ensembl chr 2:176,840,764...176,849,644
G
Pla2g2a
phospholipase A2 group IIA
decreases expression
ISO
Tetracycline results in decreased expression of PLA2G2A mRNA
CTD
PMID:16917069
NCBI chr 5:156,359,725...156,362,302
Ensembl chr 5:156,359,725...156,362,297
G
Pla2g2d
phospholipase A2, group IID
decreases expression
ISO
Tetracycline results in decreased expression of PLA2G2D mRNA
CTD
PMID:16917069
NCBI chr 5:156,299,374...156,305,816
Ensembl chr 5:156,297,777...156,305,812
G
Plcg1
phospholipase C, gamma 1
increases expression
ISO
Tetracycline results in increased expression of PLCG1 mRNA
CTD
PMID:16917069
NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:169,804,846...169,836,050
G
Plcz1
phospholipase C, zeta 1
increases expression
ISO
Tetracycline results in increased expression of PLCZ1 mRNA
CTD
PMID:16917069
NCBI chr 4:174,604,281...174,660,368
Ensembl chr 4:174,604,281...174,660,290
G
Pld1
phospholipase D1
increases expression
ISO
Tetracycline results in increased expression of PLD1 mRNA
CTD
PMID:16917069
NCBI chr 2:112,777,820...112,975,857
Ensembl chr 2:112,777,951...112,976,245
G
Plg
plasminogen
increases expression
ISO
Tetracycline results in increased expression of PLG mRNA
CTD
PMID:16917069
NCBI chr 1:50,872,927...50,915,406
Ensembl chr 1:50,872,926...50,917,320
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Plscr4
phospholipid scramblase 4
increases expression
ISO
Tetracycline results in increased expression of PLSCR4 mRNA
CTD
PMID:16917069
NCBI chr 8:101,867,057...101,905,827
Ensembl chr 8:101,866,888...101,905,831
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Polr2a
RNA polymerase II subunit A
increases expression
ISO
Tetracycline results in increased expression of POLR2A mRNA
CTD
PMID:16917069
NCBI chr10:54,951,162...54,977,179
Ensembl chr10:54,951,162...54,977,179
G
Pomc
proopiomelanocortin
increases expression
ISO
Tetracycline results in increased expression of POMC mRNA
CTD
PMID:16917069
NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173
G
Ppara
peroxisome proliferator activated receptor alpha
multiple interactions decreases expression
ISO EXP
bicyclol inhibits the reaction [Tetracycline results in decreased expression of PPARA mRNA]
CTD
PMID:19224547 PMID:19427351 PMID:24489787
NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714
G
Ppp1r3c
protein phosphatase 1, regulatory subunit 3C
increases expression
ISO
Tetracycline results in increased expression of PPP1R3C mRNA
CTD
PMID:16917069
NCBI chr 1:243,873,524...243,878,527
Ensembl chr 1:243,871,704...243,878,835
G
Prkab2
protein kinase AMP-activated non-catalytic subunit beta 2
increases expression
ISO
Tetracycline results in increased expression of PRKAB2 mRNA
CTD
PMID:16917069
NCBI chr 2:187,946,008...187,961,615
Ensembl chr 2:187,945,982...187,961,608
G
Prkag2
protein kinase AMP-activated non-catalytic subunit gamma 2
increases expression
ISO
Tetracycline results in increased expression of PRKAG2 mRNA
CTD
PMID:16917069
NCBI chr 4:10,744,695...10,985,939
Ensembl chr 4:10,744,588...10,985,939
G
Prnp
prion protein
affects binding multiple interactions
ISO
Tetracycline binds to PRNP protein Tetracycline inhibits the reaction [PRNP protein binds to PRNP protein]
CTD
PMID:10903871
NCBI chr 3:139,639,076...139,654,420
Ensembl chr 3:139,630,144...139,658,436
G
Pten
phosphatase and tensin homolog
increases expression
ISO
Tetracycline results in increased expression of PTEN mRNA
CTD
PMID:16917069
NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330
G
Ptgds
prostaglandin D2 synthase
increases expression
ISO
Tetracycline results in increased expression of PTGDS mRNA
CTD
PMID:16917069
NCBI chr 3:28,680,044...28,682,978
Ensembl chr 3:28,680,044...28,682,978
G
Ptgs2
prostaglandin-endoperoxide synthase 2
decreases expression
ISO
Tetracycline results in decreased expression of PTGS2 mRNA
CTD
PMID:24489787
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
G
Ptma
prothymosin alpha
increases expression
EXP
Tetracycline results in increased expression of PTMA mRNA
CTD
PMID:17522070
NCBI chr 9:94,624,194...94,628,276
Ensembl chr 9:94,624,196...94,628,276
G
Ptpmt1
protein tyrosine phosphatase, mitochondrial 1
decreases expression
ISO
Tetracycline results in decreased expression of PTPMT1 mRNA
CTD
PMID:16917069
NCBI chr 3:97,345,752...97,355,396
Ensembl chr 3:97,345,752...97,355,254
G
Ptpn7
protein tyrosine phosphatase, non-receptor type 7
increases expression
ISO
Tetracycline results in increased expression of PTPN7 mRNA
CTD
PMID:16917069
NCBI chr13:49,122,679...49,136,096
Ensembl chr13:49,122,609...49,136,094
G
Pvr
PVR cell adhesion molecule
increases expression
EXP
Tetracycline results in increased expression of PVR mRNA
CTD
PMID:17522070
NCBI chr 1:88,689,235...88,704,641
Ensembl chr 1:88,688,981...88,704,630
G
Pygl
glycogen phosphorylase L
decreases expression
EXP
Tetracycline results in decreased expression of PYGL mRNA
CTD
PMID:17522070
NCBI chr 6:94,433,558...94,476,219
Ensembl chr 6:94,426,346...94,476,269
G
Rab35
RAB35, member RAS oncogene family
increases expression
ISO
Tetracycline results in increased expression of RAB35 mRNA
CTD
PMID:16917069
NCBI chr12:46,627,302...46,642,815
Ensembl chr12:46,627,864...46,645,426
G
Rapgef5
Rap guanine nucleotide exchange factor 5
increases expression
ISO
Tetracycline results in increased expression of RAPGEF5 mRNA
CTD
PMID:16917069
NCBI chr 6:144,588,162...144,822,908
Ensembl chr 6:144,580,976...144,822,908
G
Rgn
regucalcin
decreases expression
EXP
Tetracycline results in decreased expression of RGN mRNA
CTD
PMID:12883083
NCBI chr X:4,172,537...4,190,112
Ensembl chr X:4,172,537...4,190,251
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Rnpep
arginyl aminopeptidase
increases expression
ISO
Tetracycline results in increased expression of RNPEP mRNA
CTD
PMID:16917069
NCBI chr13:49,251,259...49,271,440
Ensembl chr13:49,251,264...49,269,799
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Rpl23
ribosomal protein L23
increases expression
ISO
Tetracycline results in increased expression of RPL23 mRNA
CTD
PMID:16917069
NCBI chr10:83,268,223...83,272,184
Ensembl chr10:83,262,592...83,272,214
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Rps6ka2
ribosomal protein S6 kinase A2
increases expression
ISO
Tetracycline results in increased expression of RPS6KA2 mRNA
CTD
PMID:16917069
NCBI chr 1:55,178,988...55,454,271
Ensembl chr 1:55,179,319...55,454,338
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Rxrg
retinoid X receptor gamma
increases expression
ISO
Tetracycline results in increased expression of RXRG mRNA
CTD
PMID:16917069
NCBI chr13:82,276,330...82,318,097
Ensembl chr13:82,276,291...82,318,095
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S100a8
S100 calcium binding protein A8
increases expression
EXP
Tetracycline results in increased expression of S100A8 mRNA
CTD
PMID:17522070
NCBI chr 2:178,464,095...178,465,223
Ensembl chr 2:178,464,702...178,465,221
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S100a9
S100 calcium binding protein A9
increases expression
EXP
Tetracycline results in increased expression of S100A9 mRNA
CTD
PMID:17522070
NCBI chr 2:178,487,941...178,490,622
Ensembl chr 2:178,487,941...178,490,870
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Sacm1l
SAC1 like phosphatidylinositide phosphatase
increases expression
ISO
Tetracycline results in increased expression of SACM1L mRNA
CTD
PMID:16917069
NCBI chr 8:132,053,465...132,109,857
Ensembl chr 8:132,053,049...132,109,857
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Sardh
sarcosine dehydrogenase
decreases expression
ISO
Tetracycline results in decreased expression of SARDH mRNA
CTD
PMID:24489787
NCBI chr 3:30,908,621...30,973,409
Ensembl chr 3:30,908,621...30,972,137
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Scd
stearoyl-CoA desaturase
decreases expression
EXP
Tetracycline results in decreased expression of SCD mRNA
CTD
PMID:17202758
NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785
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Sdr9c7
short chain dehydrogenase/reductase family 9C, member 7
increases expression
ISO
Tetracycline results in increased expression of SDR9C7 mRNA
CTD
PMID:16917069
NCBI chr 7:65,588,726...65,607,534
Ensembl chr 7:65,593,000...65,605,630
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Sec14l4
SEC14-like lipid binding 4
increases expression
ISO
Tetracycline results in increased expression of SEC14L4 mRNA
CTD
PMID:16917069
NCBI chr14:83,136,335...83,152,382
Ensembl chr14:83,136,339...83,153,215
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Sema6d
semaphorin 6D
increases expression
ISO
Tetracycline results in increased expression of SEMA6D mRNA
CTD
PMID:16917069
NCBI chr 3:131,801,680...132,394,578
Ensembl chr 3:132,337,343...132,394,584
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Serpina3n
serpin family A member 3N
increases expression
ISO
Tetracycline results in increased expression of SERPINA3 mRNA
CTD
PMID:17175557
NCBI chr 6:129,088,392...129,095,950
Ensembl chr 6:129,088,398...129,097,415
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Sgms1
sphingomyelin synthase 1
increases expression
ISO
Tetracycline results in increased expression of SGMS1 mRNA
CTD
PMID:16917069
NCBI chr 1:239,409,991...239,681,195
Ensembl chr 1:239,409,991...239,505,774
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Slc10a1
solute carrier family 10 member 1
decreases expression
ISO EXP
Tetracycline results in decreased expression of SLC10A1 mRNA
CTD
PMID:24489787 PMID:27765674
NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944
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Slc10a2
solute carrier family 10 member 2
decreases expression
ISO
Tetracycline results in decreased expression of SLC10A2 mRNA
CTD
PMID:24489787
NCBI chr16:91,088,089...91,111,025
Ensembl chr16:91,076,423...91,111,025
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Slc16a7
solute carrier family 16 member 7
decreases expression
ISO
Tetracycline results in decreased expression of SLC16A7 mRNA
CTD
PMID:24489787
NCBI chr 7:62,929,067...63,096,995
Ensembl chr 7:62,936,567...63,040,386
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Slc1a4
solute carrier family 1 member 4
increases expression
ISO
Tetracycline results in increased expression of SLC1A4 mRNA
CTD
PMID:16917069
NCBI chr14:98,718,646...98,761,672
Ensembl chr14:98,730,450...98,761,790
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Slc22a25
solute carrier family 22, member 25
increases uptake increases export multiple interactions
ISO
SLC22A9 protein results in increased uptake of Tetracycline SLC22A9 protein results in increased export of Tetracycline Tetracycline inhibits the reaction [SLC22A9 protein results in increased uptake of Anions]
CTD
PMID:11855680
NCBI chr 1:214,767,837...214,956,535
Ensembl chr 1:214,767,837...214,862,340
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Slc22a6
solute carrier family 22 member 6
increases export multiple interactions increases uptake
ISO
SLC22A6 protein results in increased export of Tetracycline Tetracycline inhibits the reaction [SLC22A6 protein results in increased uptake of Anions] SLC22A6 protein results in increased uptake of Tetracycline
CTD
PMID:11855680
NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311
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Slc22a7
solute carrier family 22 member 7
multiple interactions increases uptake increases transport
ISO
Acetaminophen inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]; Bumetanide inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]; Chloramphenicol inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]; Diclofenac inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]; Erythromycin inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]; Furosemide inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]; Ibuprofen inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]; Indomethacin inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]; Tetracycline inhibits the reaction [SLC22A7 protein results in increased uptake of Anions] SLC22A7 protein results in increased uptake of Tetracycline
CTD
PMID:11855680 PMID:15901346
NCBI chr 9:22,044,672...22,052,051
Ensembl chr 9:22,045,435...22,051,681
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Slc22a8
solute carrier family 22 member 8
increases uptake
ISO
SLC22A8 protein results in increased uptake of Tetracycline
CTD
PMID:11855680
NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588
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Slc25a15
solute carrier family 25 member 15
decreases expression
ISO
Tetracycline results in decreased expression of SLC25A15 mRNA
CTD
PMID:24489787
NCBI chr16:76,334,037...76,357,325
Ensembl chr16:76,324,288...76,357,321
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Slc25a17
solute carrier family 25 member 17
decreases expression
ISO
Tetracycline results in decreased expression of SLC25A17 mRNA
CTD
PMID:24489787
NCBI chr 7:114,724,533...114,767,163
Ensembl chr 7:114,724,533...114,767,345
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Slc25a20
solute carrier family 25 member 20
decreases expression
ISO
Tetracycline results in decreased expression of SLC25A20 mRNA
CTD
PMID:24489787
NCBI chr 8:118,243,573...118,265,027
Ensembl chr 8:118,243,519...118,265,027
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Slc25a30
solute carrier family 25, member 30
increases expression
ISO
Tetracycline results in increased expression of SLC25A30 mRNA
CTD
PMID:16917069
NCBI chr15:57,486,346...57,508,981
Ensembl chr15:57,486,350...57,502,690
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Slc27a2
solute carrier family 27 member 2
decreases expression
ISO
Tetracycline results in decreased expression of SLC27A2 mRNA
CTD
PMID:24489787
NCBI chr 3:134,258,101...134,295,581
Ensembl chr 3:134,258,101...134,295,581
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Slc27a5
solute carrier family 27 member 5
increases expression decreases expression
ISO
Tetracycline results in increased expression of SLC27A5 mRNA Tetracycline results in decreased expression of SLC27A5 protein
CTD
PMID:25745068
NCBI chr 1:82,688,742...82,699,335
Ensembl chr 1:82,688,750...82,699,358
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Slc2a1
solute carrier family 2 member 1
increases expression
EXP
Tetracycline results in increased expression of SLC2A1 mRNA
CTD
PMID:17522070
NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742
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Slc2a2
solute carrier family 2 member 2
decreases expression
ISO
Tetracycline results in decreased expression of SLC2A2 mRNA
CTD
PMID:24489787
NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:113,537,972...113,568,467
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Slc2a3
solute carrier family 2 member 3
increases expression
EXP
Tetracycline results in increased expression of SLC2A3 mRNA
CTD
PMID:19224547
NCBI chr 4:157,632,887...157,698,034
Ensembl chr 4:157,632,887...157,646,186
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Slc2a5
solute carrier family 2 member 5
decreases expression
EXP
Tetracycline results in decreased expression of SLC2A5 mRNA
CTD
PMID:19224547
NCBI chr 5:165,857,412...165,892,928
Ensembl chr 5:165,866,172...165,894,038
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Slco1a1
solute carrier organic anion transporter family, member 1a1
decreases expression
EXP
Tetracycline results in decreased expression of SLCO1A1 mRNA
CTD
PMID:27765674
NCBI chr 4:176,606,924...176,682,027
Ensembl chr 4:176,607,687...176,681,992
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Slco1b2
solute carrier organic anion transporter family member 1B2
decreases expression
EXP
Tetracycline results in decreased expression of SLCO1B2 mRNA
CTD
PMID:17522070
NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083
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Sorl1
sortilin related receptor 1
decreases expression
ISO
Tetracycline results in decreased expression of SORL1 mRNA
CTD
PMID:16917069
NCBI chr 8:51,238,713...51,401,458
Ensembl chr 8:51,238,722...51,401,446
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Spin2b
spindlin family member 2B
decreases expression
EXP
Tetracycline results in decreased expression of SPIN2B mRNA
CTD
PMID:17522070
NCBI chr X:19,923,341...19,925,119
Ensembl chr X:19,842,295...19,925,734
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Spp1
secreted phosphoprotein 1
increases expression
ISO
Tetracycline results in increased expression of SPP1 mRNA
CTD
PMID:16917069
NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820
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Sptlc1
serine palmitoyltransferase, long chain base subunit 1
increases expression
ISO
Tetracycline results in increased expression of SPTLC1 mRNA
CTD
PMID:16917069
NCBI chr17:12,029,189...12,068,234
Ensembl chr17:12,029,189...12,068,234
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Sptlc3
serine palmitoyltransferase, long chain base subunit 3
increases expression
ISO
Tetracycline results in increased expression of SPTLC3 mRNA
CTD
PMID:16917069
NCBI chr 3:147,301,570...147,431,696
Ensembl chr 3:147,301,801...147,434,044
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Srebf1
sterol regulatory element binding transcription factor 1
increases expression decreases expression
ISO EXP
Tetracycline results in increased expression of SREBF1 mRNA Tetracycline results in decreased expression of SREBF1 mRNA
CTD
PMID:16917069 PMID:17202758 PMID:17522070 PMID:24469900 PMID:27089845
NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164
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St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
increases expression
ISO
Tetracycline results in increased expression of ST3GAL1 mRNA
CTD
PMID:16917069
NCBI chr 7:100,734,300...100,802,443
Ensembl chr 7:100,734,300...100,745,242
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St3gal4
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
increases expression
ISO
Tetracycline results in increased expression of ST3GAL4 mRNA
CTD
PMID:16917069
NCBI chr 8:41,673,510...41,723,158
Ensembl chr 8:41,673,510...41,712,551
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Stam
signal transducing adaptor molecule
increases expression
ISO
Tetracycline results in increased expression of STAM mRNA
CTD
PMID:16917069
NCBI chr17:82,028,779...82,074,717
Ensembl chr17:82,028,703...82,075,013
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Stat3
signal transducer and activator of transcription 3
increases expression
EXP
Tetracycline results in increased expression of STAT3 mRNA
CTD
PMID:17522070
NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359
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Sult2b1
sulfotransferase family 2B member 1
increases expression
ISO
Tetracycline results in increased expression of SULT2B1 mRNA
CTD
PMID:16917069
NCBI chr 1:105,336,614...105,397,744
Ensembl chr 1:105,336,614...105,397,744
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Tagln
transgelin
decreases expression
ISO
Tetracycline results in decreased expression of TAGLN mRNA
CTD
PMID:17175557
NCBI chr 8:55,121,647...55,127,121
Ensembl chr 8:55,121,301...55,127,563
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Tat
tyrosine aminotransferase
decreases expression
ISO
Tetracycline results in decreased expression of TAT mRNA
CTD
PMID:24489787
NCBI chr19:54,856,604...54,867,168
Ensembl chr19:54,856,563...54,867,482
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Tf
transferrin
decreases expression
EXP
Tetracycline results in decreased expression of TF protein
CTD
PMID:16538043
NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:112,647,642...112,695,400
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Thrsp
thyroid hormone responsive
decreases expression
ISO EXP
Tetracycline results in decreased expression of THRSP mRNA
CTD
PMID:16917069 PMID:17522070
NCBI chr 1:161,134,640...161,138,964
Ensembl chr 1:161,133,453...161,139,827
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Timp1
TIMP metallopeptidase inhibitor 1
increases expression
EXP
Tetracycline results in increased expression of TIMP1 mRNA
CTD
PMID:17522070
NCBI chr X:3,766,509...3,772,578
Ensembl chr X:3,766,510...3,771,135
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Tnfrsf1a
TNF receptor superfamily member 1A
increases expression
EXP
Tetracycline results in increased expression of TNFRSF1A mRNA
CTD
PMID:17522070
NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816
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Top2a
DNA topoisomerase II alpha
decreases expression
EXP ISO
Tetracycline results in decreased expression of TOP2A mRNA Tetracycline results in decreased expression of TOP2A protein
CTD
PMID:19224547 PMID:23293027
NCBI chr10:84,441,954...84,473,093
Ensembl chr10:84,441,954...84,473,366
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Tp53
tumor protein p53
increases expression
EXP
Tetracycline results in increased expression of TP53 mRNA
CTD
PMID:17522070
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
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Tspo
translocator protein
decreases expression
ISO
Tetracycline results in decreased expression of TSPO mRNA
CTD
PMID:16917069
NCBI chr 7:116,600,214...116,610,461
Ensembl chr 7:116,600,210...116,610,460
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Ttc1
tetratricopeptide repeat domain 1
increases expression
ISO
Tetracycline results in increased expression of TTC1 mRNA
CTD
PMID:16917069
NCBI chr10:28,703,763...28,728,910
Ensembl chr10:28,703,769...28,728,882
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Ttr
transthyretin
decreases expression
EXP
Tetracycline results in decreased expression of TTR mRNA
CTD
PMID:17522070
NCBI chr18:12,216,684...12,225,972
Ensembl chr18:12,216,732...12,225,969
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Tut1
terminal uridylyl transferase 1, U6 snRNA-specific
increases expression
ISO
Tetracycline results in increased expression of TUT1 mRNA
CTD
PMID:16917069
NCBI chr 1:215,277,802...215,288,869
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Txn1
thioredoxin 1
increases expression
EXP
Tetracycline results in increased expression of TXN mRNA
CTD
PMID:17522070
NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307
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Txnrd1
thioredoxin reductase 1
increases expression decreases expression
EXP
Tetracycline results in increased expression of TXNRD1 mRNA Tetracycline results in decreased expression of TXNRD1 mRNA
CTD
PMID:17522070 PMID:19224547
NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817
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Ugcg
UDP-glucose ceramide glucosyltransferase
increases expression
ISO
Tetracycline results in increased expression of UGCG mRNA
CTD
PMID:16917069
NCBI chr 5:78,828,006...78,860,725
Ensembl chr 5:78,828,006...78,860,417
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Ugt1a6
UDP glucuronosyltransferase family 1 member A6
decreases expression
EXP
Tetracycline results in decreased expression of UGT1A6 mRNA
CTD
PMID:19224547
NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:96,144,786...96,256,264
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Ugt2a3
UDP glucuronosyltransferase family 2 member A3
increases expression
ISO
Tetracycline results in increased expression of UGT2A3 mRNA
CTD
PMID:16917069
NCBI chr14:20,851,970...20,869,974
Ensembl chr14:20,851,969...20,869,973
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Ugt3a1
UDP glycosyltransferase family 3 member A1
increases expression
ISO
Tetracycline results in increased expression of UGT3A1 mRNA
CTD
PMID:16917069
NCBI chr 2:60,062,257...60,077,354
Ensembl chr 2:60,061,775...60,077,354
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Wipi1
WD repeat domain, phosphoinositide interacting 1
increases expression
ISO
Tetracycline results in increased expression of WIPI1 mRNA
CTD
PMID:17175557
NCBI chr10:95,042,451...95,079,679
Ensembl chr10:95,042,441...95,079,293
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Zic5
Zic family member 5
increases expression
ISO
Tetracycline results in increased expression of ZIC5 mRNA
CTD
PMID:16917069
NCBI chr15:105,964,932...105,973,669
Ensembl chr15:105,964,932...105,973,669
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Bad
BCL2-associated agonist of cell death
multiple interactions
EXP
tigecycline inhibits the reaction [Lipopolysaccharides results in increased expression of BAD protein]
CTD
PMID:23200736
NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034
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Bcl2
BCL2, apoptosis regulator
multiple interactions
EXP
tigecycline inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]
CTD
PMID:23200736
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
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Casp3
caspase 3
multiple interactions
EXP
tigecycline inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]
CTD
PMID:23200736
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
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Ccl3
C-C motif chemokine ligand 3
multiple interactions
ISO
tigecycline inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of CCL3 protein]; tigecycline inhibits the reaction [enterotoxin F, Staphylococcal results in increased expression of CCL3 protein]
CTD
PMID:19874226
NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439
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Ccl4
C-C motif chemokine ligand 4
multiple interactions
ISO
tigecycline inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of CCL4 protein]; tigecycline inhibits the reaction [enterotoxin F, Staphylococcal results in increased expression of CCL4 protein]
CTD
PMID:19874226
NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722
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Cycs
cytochrome c, somatic
multiple interactions
EXP
tigecycline inhibits the reaction [Lipopolysaccharides affects the localization of CYCS protein]
CTD
PMID:23200736
NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816 Ensembl chr18:80,982,668...80,984,816
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Il1b
interleukin 1 beta
multiple interactions
ISO EXP
tigecycline inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of IL1B protein]; tigecycline inhibits the reaction [enterotoxin F, Staphylococcal results in increased expression of IL1B protein] Tigecycline inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Tigecycline inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
CTD
PMID:19874226 PMID:23200736
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
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Il6
interleukin 6
multiple interactions
ISO
Tigecycline inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of IL6 protein]; Tigecycline inhibits the reaction [enterotoxin F, Staphylococcal results in increased expression of IL6 protein]
CTD
PMID:19874226
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
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Tnf
tumor necrosis factor
multiple interactions
ISO EXP
tigecycline inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of TNF protein]; tigecycline inhibits the reaction [enterotoxin F, Staphylococcal results in increased expression of TNF protein] tigecycline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; tigecycline inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD
PMID:19874226 PMID:23200736
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
20862
role
20820
biological role
20818
biochemical role
20264
metabolite
20245
tetracyclines
527
(+)-viridicatumtoxin B
0
(4R,12aR)-4,7-bis(dimethylamino)-10,12a-dihydroxy-1,3,11,12-tetraoxo-4,4a,5,5a,6,11a-hexahydrotetracene-2-carboxamide
0
(4S,4aR,5S,12aS)-7-chloro-4-(dimethylamino)-5,10,12a-trihydroxy-6-methylene-1,3,11,12-tetraoxo-4a,5,5a,11a-tetrahydro-4H-tetracene-2-carboxamide
0
(4S,4aS,5aR,12aS)-9-[[2-(tert-butylamino)-1-oxoethyl]amino]-4,7-bis(dimethylamino)-10,12a-dihydroxy-1,3,11,12-tetraoxo-4,4a,5,5a,6,11a-hexahydrotetracene-2-carboxamide
0
(4S,4aS,5aR,6S,12aS)-7-chloro-4-(dimethylamino)-6,10,12a-trihydroxy-6-methyl-1,3,11,12-tetraoxo-4a,5,5a,11a-tetrahydro-4H-tetracene-2-carboxamide
0
(4S,4aS,6S,12aS)-7-chloro-4-(dimethylamino)-6,10,12a-trihydroxy-6-methyl-1,3,11,12-tetraoxo-4a,5,5a,11a-tetrahydro-4H-tetracene-2-carboxamide
0
(4aS,5aR,12aS)-10,12a-dihydroxy-1,3,11,12-tetraoxo-4,4a,5,5a,6,11a-hexahydrotetracene-2-carboxamide
0
(4aS,5aS,12aS)-7-chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboximidic acid
0
11a-Hydroxy-7-chlortetracycline
0
11a-hydroxy-7-iodotetracycline zwitterion
0
11a-hydroxychlortetracycline zwitterion
0
11a-hydroxytetracycline
0
11a-hydroxytigecycline(1+)
0
12-dehydrotetracycline
0
4-(dimethylamino)-5,10,12a-trihydroxy-6-methyl-1,3,11,12-tetraoxo-4,4a,5,5a,6,11a-hexahydrotetracene-2-carboxamide
0
4-(dimethylamino)-6,10,12a-trihydroxy-6-methyl-1,3,11,12-tetraoxo-4a,5,5a,11a-tetrahydro-4H-tetracene-2-carboxamide
0
4-Amino-anhydrotetracycline
0
4-Aminoanhydrochlortetracycline
0
4-Epianhydrotetracycline hydrochloride
0
4-amino-4-de(dimethylamino)anhydrotetracycline
0
4-de(dimethylamino)-4-oxoanhydrotetracycline
0
4-dedimethylamine-4-oxo-anhydro-7-Cl-tetracycline
0
4-epi-Chlortetracycline Hydrochloride
0
5-Hydroxy-7-chlortetracycline
0
5-hydroxyanthrotainin
0
5a,11a-Dehydrochlortetracycline
0
5a,11a-dehydrooxytetracycline
0
5a,6-anhydrotetracycline
0
6-demethyltetracycline
0
7-chloro-4-(dimethylamino)-6,10,12a-trihydroxy-1,3,11,12-tetraoxo-4,4a,5,5a,6,11a-hexahydrotetracene-2-carboxamide
0
8-O-desmethylanthrotainin
0
Anhydrochlortetracycline
0
Anhydrochlortetracycline hydrochloride
0
Anhydrotetracycline hydrochloride
0
Anthrotainin
0
BMS-192548
0
DMG-MINO
0
Dactylocycline A
0
Dactylocycline B
0
Epianhydrochlortetracycline hydrochloride
0
Epitetracycline hydrochloride
0
Eravacycline
0
Omadacycline
2
Oxytetracycline Impurity A
0
Pretetramid +
0
Previridicatumtoxin
0
SF2575
0
Sancycline hydrochloride
0
Sarecycline hydrochloride
0
Sodium terramycin
0
TAN-1518 A
0
TAN-1518 B
0
TAN-1612
0
Viridicatumtoxin B
0
a tetracycline zwitterion +
0
anhydrotetracycline +
0
chlortetracycline
2
clomocycline
0
demeclocycline +
3
desmethylanhydrotetracycline
0
doxycycline +
79
guamecycline
0
iodtetracycline(1-) +
0
lymecycline
0
meclocycline
6
methacycline
0
minocycline +
113
nitrocycline
0
oxytetracycline
10
pipacycline
0
pretetramide +
0
rolitetracycline
0
sancycline
0
tetracycline +
380
tigecycline +
9
Path 2
CHEBI ontology
20862
subatomic particle
20860
composite particle
20860
hadron
20860
baryon
20860
nucleon
20860
atomic nucleus
20860
atom
20860
main group element atom
20781
main group molecular entity
20781
s-block molecular entity
20574
hydrogen molecular entity
20558
hydrides
19693
organic hydride
19079
organic fundamental parent
19079
hydrocarbon
18731
cyclic hydrocarbon
17330
arene
17311
polycyclic arene
17112
ortho-fused polycyclic arene
9959
acene
7855
tetracene
7852
tetracyclines
527
(+)-viridicatumtoxin B
0
(4R,12aR)-4,7-bis(dimethylamino)-10,12a-dihydroxy-1,3,11,12-tetraoxo-4,4a,5,5a,6,11a-hexahydrotetracene-2-carboxamide
0
(4S,4aR,5S,12aS)-7-chloro-4-(dimethylamino)-5,10,12a-trihydroxy-6-methylene-1,3,11,12-tetraoxo-4a,5,5a,11a-tetrahydro-4H-tetracene-2-carboxamide
0
(4S,4aS,5aR,12aS)-9-[[2-(tert-butylamino)-1-oxoethyl]amino]-4,7-bis(dimethylamino)-10,12a-dihydroxy-1,3,11,12-tetraoxo-4,4a,5,5a,6,11a-hexahydrotetracene-2-carboxamide
0
(4S,4aS,5aR,6S,12aS)-7-chloro-4-(dimethylamino)-6,10,12a-trihydroxy-6-methyl-1,3,11,12-tetraoxo-4a,5,5a,11a-tetrahydro-4H-tetracene-2-carboxamide
0
(4S,4aS,6S,12aS)-7-chloro-4-(dimethylamino)-6,10,12a-trihydroxy-6-methyl-1,3,11,12-tetraoxo-4a,5,5a,11a-tetrahydro-4H-tetracene-2-carboxamide
0
(4aS,5aR,12aS)-10,12a-dihydroxy-1,3,11,12-tetraoxo-4,4a,5,5a,6,11a-hexahydrotetracene-2-carboxamide
0
(4aS,5aS,12aS)-7-chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboximidic acid
0
11a-Hydroxy-7-chlortetracycline
0
11a-hydroxy-7-iodotetracycline zwitterion
0
11a-hydroxychlortetracycline zwitterion
0
11a-hydroxytetracycline
0
11a-hydroxytigecycline(1+)
0
12-dehydrotetracycline
0
4-(dimethylamino)-5,10,12a-trihydroxy-6-methyl-1,3,11,12-tetraoxo-4,4a,5,5a,6,11a-hexahydrotetracene-2-carboxamide
0
4-(dimethylamino)-6,10,12a-trihydroxy-6-methyl-1,3,11,12-tetraoxo-4a,5,5a,11a-tetrahydro-4H-tetracene-2-carboxamide
0
4-Amino-anhydrotetracycline
0
4-Aminoanhydrochlortetracycline
0
4-Epianhydrotetracycline hydrochloride
0
4-amino-4-de(dimethylamino)anhydrotetracycline
0
4-de(dimethylamino)-4-oxoanhydrotetracycline
0
4-dedimethylamine-4-oxo-anhydro-7-Cl-tetracycline
0
4-epi-Chlortetracycline Hydrochloride
0
5-Hydroxy-7-chlortetracycline
0
5-hydroxyanthrotainin
0
5a,11a-Dehydrochlortetracycline
0
5a,11a-dehydrooxytetracycline
0
5a,6-anhydrotetracycline
0
6-demethyltetracycline
0
7-chloro-4-(dimethylamino)-6,10,12a-trihydroxy-1,3,11,12-tetraoxo-4,4a,5,5a,6,11a-hexahydrotetracene-2-carboxamide
0
8-O-desmethylanthrotainin
0
Anhydrochlortetracycline
0
Anhydrochlortetracycline hydrochloride
0
Anhydrotetracycline hydrochloride
0
Anthrotainin
0
BMS-192548
0
DMG-MINO
0
Dactylocycline A
0
Dactylocycline B
0
Epianhydrochlortetracycline hydrochloride
0
Epitetracycline hydrochloride
0
Eravacycline
0
Omadacycline
2
Oxytetracycline Impurity A
0
Pretetramid +
0
Previridicatumtoxin
0
SF2575
0
Sancycline hydrochloride
0
Sarecycline hydrochloride
0
Sodium terramycin
0
TAN-1518 A
0
TAN-1518 B
0
TAN-1612
0
Viridicatumtoxin B
0
a tetracycline zwitterion +
0
anhydrotetracycline +
0
chlortetracycline
2
clomocycline
0
demeclocycline +
3
desmethylanhydrotetracycline
0
doxycycline +
79
guamecycline
0
iodtetracycline(1-) +
0
lymecycline
0
meclocycline
6
methacycline
0
minocycline +
113
nitrocycline
0
oxytetracycline
10
pipacycline
0
pretetramide +
0
rolitetracycline
0
sancycline
0
tetracycline +
380
tigecycline +
9