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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tetrachlorobenzene
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Accession:CHEBI:26888 term browser browse the term
Definition:Any member of the class of chlorobenzenes carrying four chloro groups at unspecified positions.
Synonyms:related_synonym: Formula=C6H2Cl4;   Tetrachlorbenzol
 xref: CAS:12408-10-5


show annotations for term's descendants           Sort by:
1,2,3,5-tetrachlorobenzene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing
increases oxidation		 ISO CYP2E1 protein results in increased metabolism of 1,2,3,5-tetrachlorobenzene
CYP2E1 protein results in increased oxidation of 1,2,3,5-tetrachlorobenzene		 CTD PMID:7747284 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases oxidation ISO CYP3A4 protein results in increased oxidation of 1,2,3,5-tetrachlorobenzene CTD PMID:7747284 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
1,2,4,5-tetrachlorobenzene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP 1,2,4,5-tetrachlorobenzene results in increased expression of CYP1A2 protein CTD PMID:10696772 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP 1,2,4,5-tetrachlorobenzene results in increased expression of CYP2B1 protein CTD PMID:10696772 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression EXP 1,2,4,5-tetrachlorobenzene results in increased expression of CYP2E1 protein CTD PMID:10696772 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP 1,2,4,5-tetrachlorobenzene results in increased expression of FOS protein CTD PMID:10696772 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
2,3,3',4,4',5,5'-Heptachlorobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn1 actinin, alpha 1 decreases expression ISO 2,2',3,3',4,4',5-heptachlorobiphenyl results in decreased expression of ACTN1 mRNA CTD PMID:26238599 NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251 		JBrowse link
G Ar androgen receptor multiple interactions ISO 2,2',3,3',4,4',5-heptachlorobiphenyl inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein] CTD PMID:21357386 PMID:26022396 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member decreases expression ISO 2,2',3,3',4,4',5-heptachlorobiphenyl results in decreased expression of BCAR1 mRNA CTD PMID:26238599 NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP 2,3,4,5,3',4',5'-heptachlorobiphenyl results in increased expression of CYP1A1 mRNA CTD PMID:25654323 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity ISO 2,2',3,3',4,4',5-heptachlorobiphenyl results in increased activity of CYP1A2 protein CTD PMID:15743714 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression EXP 2,3,4,5,3',4',5'-heptachlorobiphenyl results in increased expression of CYP1B1 mRNA CTD PMID:25654323 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO 2,2',3,3',4,4',5-heptachlorobiphenyl results in increased phosphorylation of MAPK1 protein CTD PMID:19751709 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO 2,2',3,3',4,4',5-heptachlorobiphenyl results in increased phosphorylation of MAPK3 protein CTD PMID:19751709 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases phosphorylation ISO 2,2',3,3',4,4',5-heptachlorobiphenyl results in increased phosphorylation of MDM2 protein CTD PMID:19751709 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression ISO 2,2',3,3',4,4',5-heptachlorobiphenyl results in decreased expression of MET mRNA CTD PMID:26238599 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO 2,2',3,3',4,4',5-heptachlorobiphenyl results in decreased expression of MMP9 mRNA CTD PMID:26238599 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO 2,2',3,3',4,4',5-heptachlorobiphenyl results in increased activity of NR1I2 protein CTD PMID:25680588 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO 2,2',3,3',4,4',5-heptachlorobiphenyl inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein] CTD PMID:26022396 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Rhoc ras homolog family member C decreases expression ISO 2,2',3,3',4,4',5-heptachlorobiphenyl results in decreased expression of RHOC mRNA CTD PMID:26238599 NCBI chr 2:192,287,065...192,293,292
Ensembl chr 2:192,287,130...192,295,306 		JBrowse link
G Ttr transthyretin affects binding
multiple interactions		 ISO 2,2',3,3',4,4',5-heptachlorobiphenyl binds to TTR protein
2,2',3,3',4,4',5-heptachlorobiphenyl inhibits the reaction [Thyroxine binds to TTR protein]		 CTD PMID:21357386 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008 		JBrowse link
2,3,3',4,4',5-Hexachlorobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases activity
multiple interactions
affects binding		 ISO
EXP		 2,3,3',4,4',5-hexachlorobiphenyl results in increased activity of AHR protein
2,3,3',4,4',5-hexachlorobiphenyl binds to and results in increased activity of AHR protein; 2,3,3',4,4',5-hexachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; 2,3,3',4,4',5-hexachlorobiphenyl promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
2,3,3',4,4',5-hexachlorobiphenyl binds to AHR protein		 CTD PMID:10448124 PMID:11339718 PMID:12850102 PMID:15352264 PMID:20728228 More... NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor increases expression EXP 2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of AHRR mRNA CTD PMID:29738842 NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 increases expression EXP 2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of ALDH3A1 mRNA CTD PMID:29738842 NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681 		JBrowse link
G Ar androgen receptor multiple interactions ISO 2,3,3',4,4',5-hexachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 increases expression ISO 2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of CYP11B1 mRNA CTD PMID:16396990 NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases expression ISO 2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of CYP11B2 mRNA CTD PMID:16396990 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
increases activity		 ISO
EXP		 2,3,3',4,4',5-hexachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of CYP1A1 mRNA; 2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of CYP1A1 protein
2,3,3',4,4',5-hexachlorobiphenyl results in increased activity of CYP1A1 protein
2,3,3',4,4',5-hexachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; [Tetrachlorodibenzodioxin co-treated with 2,3,3',4,4',5-hexachlorobiphenyl] results in increased expression of CYP1A1 protein		 CTD PMID:10986007 PMID:11339718 PMID:15352264 PMID:16750337 PMID:18493746 More... NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
multiple interactions
increases expression
decreases activity		 ISO
EXP		 2,3,3',4,4',5-hexachlorobiphenyl results in increased activity of CYP1A2 protein
2,3,3',4,4',5-hexachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of CYP1A2 mRNA
2,3,3',4,4',5-hexachlorobiphenyl results in decreased activity of CYP1A2 protein		 CTD PMID:10986007 PMID:15659567 PMID:18493746 PMID:23674508 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO
EXP		 2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of CYP1B1 mRNA CTD PMID:23674508 PMID:25654323 PMID:29738842 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Esr1 estrogen receptor 1 affects binding ISO 2,3,3',4,4',5-hexachlorobiphenyl binds to ESR1 protein CTD PMID:16293362 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2,3,3',4,4',5-hexachlorobiphenyl binds to and results in increased activity of MAPK1 protein CTD PMID:16293362 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2,3,3',4,4',5-hexachlorobiphenyl binds to and results in increased activity of MAPK3 protein CTD PMID:16293362 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity
multiple interactions		 ISO 2,3,3',4,4',5-hexachlorobiphenyl results in increased activity of NR1I3 protein
2,3,3',4,4',5-hexachlorobiphenyl inhibits the reaction [Androstenols results in decreased activity of NR1I3 protein]		 CTD PMID:19746742 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase increases expression EXP 2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of TIPARP mRNA CTD PMID:29738842 NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327 		JBrowse link
2,3,4,5-Tetrachloro-4'-biphenylol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein affects binding EXP 4-hydroxy-2',3',4'-5'-tetrachlorobiphenyl binds to AFP protein CTD PMID:23013281 PMID:25349334 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Ar androgen receptor affects binding EXP 2',3',4',5'-tetrachloro-4-biphenylol binds to AR protein CTD PMID:14565775 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV multiple interactions ISO 2',3',4',5'-tetrachloro-4-biphenylol inhibits the reaction [Diethylstilbestrol results in increased activity of CAMK4 protein]; 2',3',4',5'-tetrachloro-4-biphenylol inhibits the reaction [Estradiol results in increased activity of CAMK4 protein] CTD PMID:16413991 NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
affects binding		 ISO 2',3',4',5'-tetrachloro-4-biphenylol binds to and results in increased activity of ESR1 protein; 2',3',4',5'-tetrachloro-4-biphenylol inhibits the reaction [Estradiol binds to ESR1 protein]
2',3',4',5'-tetrachloro-4-biphenylol binds to ESR1 protein		 CTD PMID:10964929 PMID:11530281 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 affects binding
multiple interactions		 ISO 2',3',4',5'-tetrachloro-4-biphenylol binds to ESR2 protein
2',3',4',5'-tetrachloro-4-biphenylol inhibits the reaction [Estradiol binds to ESR2 protein]; 2',3',4',5'-tetrachloro-4-biphenylol promotes the reaction [ESR2 protein binds to NCOA1 protein]; 2',3',4',5'-tetrachloro-4-biphenylol promotes the reaction [ESR2 protein binds to NCOA2 protein]		 CTD PMID:10964929 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO 2',3',4',5'-tetrachloro-4-biphenylol promotes the reaction [ESR2 protein binds to NCOA1 protein] CTD PMID:10964929 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO 2',3',4',5'-tetrachloro-4-biphenylol promotes the reaction [ESR2 protein binds to NCOA2 protein] CTD PMID:10964929 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO 4-hydroxy-2',3',4'-5'-tetrachlorobiphenyl analog results in increased activity of NR1I3 protein; 4-hydroxy-2',3',4'-5'-tetrachlorobiphenyl results in increased activity of NR1I3 protein CTD PMID:26231822 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO 4-hydroxy-2',3',4'-5'-tetrachlorobiphenyl inhibits the reaction [Progesterone binds to PGR protein]; [Progesterone co-treated with 4-hydroxy-2',3',4'-5'-tetrachlorobiphenyl] results in decreased expression of PGR mRNA CTD PMID:9144411 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Shbg sex hormone binding globulin affects binding ISO 4-hydroxy-2',3',4'-5'-tetrachlorobiphenyl binds to SHBG protein CTD PMID:25349334 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
2,3,4,5-tetrachlorobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO 2,3,4,5-tetrachlorobiphenyl results in increased activity of NR1I3 protein CTD PMID:26231822 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
2,3,4,5-tetrachlorophenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grip1 glutamate receptor interacting protein 1 affects response to substance ISO GRIP1 gene SNP affects the susceptibility to 2,3,4,5-tetrachlorophenate CTD PMID:25622337 NCBI chr 7:54,934,856...55,592,274
Ensembl chr 7:54,934,250...55,592,273 		JBrowse link
G Hlcs holocarboxylase synthetase affects response to substance ISO HLCS gene SNP affects the susceptibility to 2,3,4,5-tetrachlorophenate CTD PMID:25622337 NCBI chr11:33,455,806...33,635,197
Ensembl chr11:33,455,809...33,624,222 		JBrowse link
G Lyzl1 lysozyme-like 1 affects response to substance ISO LYZL1 gene SNP affects the susceptibility to 2,3,4,5-tetrachlorophenate CTD PMID:25622337 NCBI chr17:53,530,437...53,543,877
Ensembl chr17:53,530,442...53,543,866 		JBrowse link
G Slc6a19 solute carrier family 6 member 19 affects response to substance ISO SLC6A19 gene SNP affects the susceptibility to 2,3,4,5-tetrachlorophenate CTD PMID:25622337 NCBI chr 1:29,586,191...29,604,964
Ensembl chr 1:29,586,195...29,604,962 		JBrowse link
G Tspan15 tetraspanin 15 affects response to substance ISO TSPAN15 gene SNP affects the susceptibility to 2,3,4,5-tetrachlorophenate CTD PMID:25622337 NCBI chr20:30,130,528...30,174,912
Ensembl chr20:30,130,530...30,174,930 		JBrowse link
G Zfp804b zinc finger protein 804B affects response to substance ISO ZNF804B gene SNP affects the susceptibility to 2,3,4,5-tetrachlorophenate CTD PMID:25622337 NCBI chr 4:26,608,510...27,144,717
Ensembl chr 4:26,609,744...27,141,673 		JBrowse link
2,3,4,6-tetrachlorophenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tp53 tumor protein p53 affects activity ISO 2,3,4,6-tetrachlorophenol affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
2,3,5,6-tetrachlorobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO 2,3,5,6-tetrachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO 2,3,5,6-tetrachlorobiphenyl analog results in increased activity of NR1I3 protein; 2,3,5,6-tetrachlorobiphenyl results in increased activity of NR1I3 protein CTD PMID:26231822 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
2,3,5,6-tetrachlorophenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases oxidation ISO CYP2E1 protein results in increased oxidation of 2,3,5,6-tetrachlorophenate CTD PMID:7747284 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO 2,3,5,6-tetrachlorophenate affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
2-Hydroxy-2',3',4',5,5'-pentachlorobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO 2',3',4',5,5'-pentachloro-2-biphenylol results in increased activity of NR1I3 protein CTD PMID:26231822 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
chlorothalonil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acly ATP citrate lyase decreases expression
multiple interactions		 ISO tetrachloroisophthalonitrile results in decreased expression of ACLY mRNA
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of ACLY mRNA		 CTD PMID:33246813 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320 		JBrowse link
G Acot1 acyl-CoA thioesterase 1 decreases expression
multiple interactions		 ISO tetrachloroisophthalonitrile results in decreased expression of ACOT1 mRNA
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of ACOT1 mRNA		 CTD PMID:33246813 NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions
decreases expression		 ISO [procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of ACOX1 mRNA
tetrachloroisophthalonitrile results in decreased expression of ACOX1 mRNA		 CTD PMID:33246813 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of ACTA2 mRNA CTD PMID:32289622 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions EXP tetrachloroisophthalonitrile binds to and results in increased activity of AHR protein CTD PMID:14636698 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Angpt4 angiopoietin 4 multiple interactions ISO [tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of ANGPT4 mRNA CTD PMID:33246813 NCBI chr 3:140,420,389...140,454,213
Ensembl chr 3:140,420,389...140,453,583 		JBrowse link
G Ano1 anoctamin 1 increases expression ISO tetrachloroisophthalonitrile results in increased expression of ANO1 mRNA CTD PMID:33246813 NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO tetrachloroisophthalonitrile results in increased expression of BAD mRNA CTD PMID:34549778 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO tetrachloroisophthalonitrile results in increased expression of BAX protein
tetrachloroisophthalonitrile results in increased expression of BAX mRNA		 CTD PMID:30586609 PMID:34549778 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of BCL2 protein CTD PMID:30586609 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bmp15 bone morphogenetic protein 15 decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of BMP15 protein CTD PMID:30586609 NCBI chr  X:16,169,123...16,174,187
Ensembl chr  X:16,169,123...16,174,187 		JBrowse link
G Casp3 caspase 3 increases activity
increases expression		 ISO tetrachloroisophthalonitrile results in increased activity of CASP3 protein
tetrachloroisophthalonitrile results in increased expression of CASP3 mRNA		 CTD PMID:34549778 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases expression ISO tetrachloroisophthalonitrile results in increased expression of CASP8 mRNA CTD PMID:34549778 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of CCL2 mRNA CTD PMID:32289622 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of CCL4 mRNA CTD PMID:32289622 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Cftr CF transmembrane conductance regulator decreases expression
multiple interactions		 ISO tetrachloroisophthalonitrile results in decreased expression of CFTR protein
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of CFTR protein; [tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of CFTR mRNA		 CTD PMID:33246813 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Cldn1 claudin 1 decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of CLDN1 mRNA; tetrachloroisophthalonitrile results in decreased expression of CLDN1 protein CTD PMID:34549778 NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724 		JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of COL1A1 mRNA; tetrachloroisophthalonitrile metabolite results in increased expression of COL1A1 protein CTD PMID:32289622 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression
multiple interactions		 ISO tetrachloroisophthalonitrile results in decreased expression of CPT1A mRNA
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of CPT1A mRNA		 CTD PMID:33246813 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of CXCL2 mRNA CTD PMID:32289622 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of CYP11A1 protein CTD PMID:30586609 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Defa3 defensin alpha 3 multiple interactions ISO [tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of DEFA3 mRNA CTD PMID:33246813 NCBI chr16:70,533,436...70,535,592
Ensembl chr16:70,533,436...70,535,604 		JBrowse link
G Defa5 defensin alpha 5 multiple interactions ISO [tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of DEFA5 mRNA CTD PMID:33246813 NCBI chr16:70,342,530...70,344,854
Ensembl chr16:70,342,530...70,344,836 		JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 multiple interactions
decreases expression		 ISO [procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of DGAT1 mRNA
tetrachloroisophthalonitrile results in decreased expression of DGAT1 mRNA		 CTD PMID:33246813 NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 decreases expression
multiple interactions		 ISO tetrachloroisophthalonitrile results in decreased expression of DGAT2 mRNA
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of DGAT2 mRNA		 CTD PMID:33246813 NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428 		JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO tetrachloroisophthalonitrile results in decreased activity of DIO1 protein CTD PMID:29228274 PMID:30561685 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970 		JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases activity ISO tetrachloroisophthalonitrile results in decreased activity of DIO2 protein CTD PMID:30561685 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809 		JBrowse link
G Dio3 iodothyronine deiodinase 3 decreases activity ISO tetrachloroisophthalonitrile results in decreased activity of DIO3 protein CTD PMID:30561685 NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660 		JBrowse link
G Egfr epidermal growth factor receptor decreases phosphorylation ISO tetrachloroisophthalonitrile results in decreased phosphorylation of EGFR protein CTD PMID:28426875 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 increases activity ISO tetrachloroisophthalonitrile results in increased activity of ERBB2 protein CTD PMID:11222871 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression
multiple interactions		 ISO tetrachloroisophthalonitrile results in decreased expression of FABP1 mRNA
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of FABP1 mRNA		 CTD PMID:33246813 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Fasn fatty acid synthase decreases expression
multiple interactions		 ISO tetrachloroisophthalonitrile results in decreased expression of FASN mRNA
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of FASN mRNA		 CTD PMID:33246813 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fshr follicle stimulating hormone receptor decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of FSHR protein CTD PMID:30586609 NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785 		JBrowse link
G Gck glucokinase multiple interactions
decreases expression		 ISO [procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of GCK mRNA
tetrachloroisophthalonitrile results in decreased expression of GCK mRNA		 CTD PMID:33246813 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995 		JBrowse link
G Gdf9 growth differentiation factor 9 decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of GDF9 protein CTD PMID:30586609 NCBI chr10:37,589,200...37,599,970
Ensembl chr10:37,595,679...37,599,672 		JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of GJA1 protein CTD PMID:30586609 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial multiple interactions
decreases expression		 ISO [procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of GPAM mRNA
tetrachloroisophthalonitrile results in decreased expression of GPAM mRNA		 CTD PMID:33246813 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of HSD17B4 protein CTD PMID:30586609 NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of HSD3B1 protein CTD PMID:30586609 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of IL1A mRNA CTD PMID:32289622 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of IL1B mRNA CTD PMID:32289622 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of IL6 mRNA CTD PMID:32289622 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 decreases expression
multiple interactions		 ISO tetrachloroisophthalonitrile results in decreased expression of INS1 protein
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of INS1 protein		 CTD PMID:33246813 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Klf4 KLF transcription factor 4 multiple interactions
increases expression		 ISO [tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of KLF4 mRNA
tetrachloroisophthalonitrile results in increased expression of KLF4 mRNA		 CTD PMID:33246813 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO tetrachloroisophthalonitrile results in decreased phosphorylation of MAPK1 protein CTD PMID:28426875 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO tetrachloroisophthalonitrile results in decreased phosphorylation of MAPK3 protein CTD PMID:28426875 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO tetrachloroisophthalonitrile results in increased phosphorylation of MAPK8 protein CTD PMID:34549778 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mep1b meprin A subunit beta multiple interactions
increases expression		 ISO [tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of MEP1B mRNA
tetrachloroisophthalonitrile results in increased expression of MEP1B mRNA		 CTD PMID:33246813 NCBI chr18:12,366,126...12,392,840
Ensembl chr18:12,365,289...12,392,840 		JBrowse link
G Mif macrophage migration inhibitory factor decreases expression ISO tetrachloroisophthalonitrile metabolite results in decreased expression of MIF mRNA CTD PMID:32289622 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504 		JBrowse link
G Mlxip MLX interacting protein multiple interactions ISO [procymidone co-treated with tetrachloroisophthalonitrile] results in increased expression of MLXIP mRNA CTD PMID:33246813 NCBI chr12:33,128,524...33,192,300
Ensembl chr12:33,128,520...33,192,374 		JBrowse link
G Mmp1 matrix metallopeptidase 1 decreases expression ISO tetrachloroisophthalonitrile metabolite results in decreased expression of MMP1 mRNA CTD PMID:32289622 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp3 matrix metallopeptidase 3 decreases expression ISO tetrachloroisophthalonitrile metabolite results in decreased expression of MMP3 mRNA CTD PMID:32289622 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of MMP9 mRNA CTD PMID:32289622 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions ISO [procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of MTTP mRNA CTD PMID:33246813 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239 		JBrowse link
G Muc1 mucin 1, cell surface associated increases expression ISO tetrachloroisophthalonitrile results in increased expression of MUC1 mRNA CTD PMID:33246813 NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733 		JBrowse link
G Muc17 mucin 17, cell surface associated multiple interactions ISO [tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of MUC17 mRNA CTD PMID:33246813 NCBI chr12:19,527,251...19,536,924
Ensembl chr12:19,527,321...19,538,522 		JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming increases expression
decreases expression
multiple interactions		 ISO tetrachloroisophthalonitrile results in increased expression of MUC2 mRNA
tetrachloroisophthalonitrile results in decreased expression of MUC2 protein
[tetrachloroisophthalonitrile co-treated with procymidone] results in decreased expression of MUC2 protein		 CTD PMID:33246813 NCBI chr 1:196,799,494...196,831,740
Ensembl chr 1:196,799,517...196,831,756 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO tetrachloroisophthalonitrile results in increased activity of NR1I2 protein CTD PMID:20143881 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Ocln occludin decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of OCLN mRNA CTD PMID:34549778 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Pklr pyruvate kinase L/R decreases expression
multiple interactions		 ISO tetrachloroisophthalonitrile results in decreased expression of PKLR mRNA
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of PKLR mRNA		 CTD PMID:33246813 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870 		JBrowse link
G Pla2g4a phospholipase A2 group 4A multiple interactions ISO [tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of PLA2G4A mRNA CTD PMID:33246813 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression
multiple interactions		 ISO tetrachloroisophthalonitrile results in decreased expression of PPARA mRNA
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of PPARA mRNA		 CTD PMID:33246813 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression
multiple interactions		 ISO tetrachloroisophthalonitrile results in decreased expression of PPARG mRNA
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of PPARG mRNA		 CTD PMID:33246813 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of PTGS2 mRNA CTD PMID:32289622 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rad51 RAD51 recombinase increases expression ISO tetrachloroisophthalonitrile results in increased expression of RAD51 protein CTD PMID:30586609 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of S100A8 mRNA CTD PMID:32289622 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643 		JBrowse link
G S100a9 S100 calcium binding protein A9 decreases expression ISO tetrachloroisophthalonitrile metabolite results in decreased expression of S100A9 mRNA CTD PMID:32289622 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions
decreases expression		 ISO [procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of SCD1 mRNA
tetrachloroisophthalonitrile results in decreased expression of SCD1 mRNA		 CTD PMID:33246813 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Slc12a2 solute carrier family 12 member 2 multiple interactions ISO [tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of SLC12A2 mRNA CTD PMID:33246813 NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440 		JBrowse link
G Slc26a3 solute carrier family 26 member 3 multiple interactions
increases expression		 ISO [tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of SLC26A3 mRNA
tetrachloroisophthalonitrile results in increased expression of SLC26A3 mRNA		 CTD PMID:33246813 NCBI chr 6:48,023,892...48,064,829
Ensembl chr 6:48,023,892...48,064,772 		JBrowse link
G Slc26a6 solute carrier family 26 member 6 increases expression ISO tetrachloroisophthalonitrile results in increased expression of SLC26A6 mRNA CTD PMID:33246813 NCBI chr 8:109,558,968...109,569,778
Ensembl chr 8:109,559,642...109,569,778 		JBrowse link
G Slc27a2 solute carrier family 27 member 2 decreases expression
multiple interactions		 ISO tetrachloroisophthalonitrile results in decreased expression of SLC27A2 mRNA
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of SLC27A2 mRNA		 CTD PMID:33246813 NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208 		JBrowse link
G Slc9a3 solute carrier family 9 member A3 multiple interactions
increases expression		 ISO [tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of SLC9A3 mRNA
tetrachloroisophthalonitrile results in increased expression of SLC9A3 mRNA		 CTD PMID:33246813 NCBI chr 1:29,124,633...29,167,912
Ensembl chr 1:29,124,674...29,167,417 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases activity ISO tetrachloroisophthalonitrile results in decreased activity of TGFB1 protein CTD PMID:31652400 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tjp1 tight junction protein 1 decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of TJP1 mRNA CTD PMID:34549778 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tlr4 toll-like receptor 4 increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of TLR4 mRNA CTD PMID:32289622 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of TNF mRNA CTD PMID:32289622 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
phloxine O term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tslp thymic stromal lymphopoietin multiple interactions ISO Phloxine O inhibits the reaction [calcipotriol increases expression of Tslp mRNA and protein in skin of external ear and phorbol 12-myristate 13-acetate increases expression of Tslp protein in keratinocytes] RGD PMID:29310423 RGD:38549374 NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548 		JBrowse link
tetrachlorocatechol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO 3,4,5,6-tetrachlorocatechol results in increased activity of CASP3 protein CTD PMID:19766705 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Comt catechol-O-methyltransferase increases methylation ISO COMT protein results in increased methylation of 3,4,5,6-tetrachlorocatechol CTD PMID:11160877 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
tetrachlorohydroquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO 2,3,5,6-tetrachlorohydroquinone results in decreased activity of ACHE protein CTD PMID:30905860 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Ar androgen receptor multiple interactions ISO 2,3,5,6-tetrachlorohydroquinone inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO 2,3,5,6-tetrachlorohydroquinone results in decreased expression of BCL2 protein CTD PMID:11064002 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases activity ISO 2,3,5,6-tetrachlorohydroquinone results in increased activity of CASP3 protein CTD PMID:30905860 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cse1l chromosome segregation 1 like decreases expression ISO 2,3,5,6-tetrachlorohydroquinone results in decreased expression of CSE1L protein CTD PMID:11064002 NCBI chr 3:155,641,104...155,678,866
Ensembl chr 3:155,641,166...155,678,865 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO 2,3,5,6-tetrachlorohydroquinone results in increased expression of PCNA protein CTD PMID:12669308 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Tet1 tet methylcytosine dioxygenase 1 multiple interactions ISO TET1 protein affects the reaction [2,3,5,6-tetrachlorohydroquinone results in increased chemical synthesis of 5-hydroxymethylcytosine]; TET1 protein affects the reaction [2,3,5,6-tetrachlorohydroquinone results in increased oxidation of 5-Methylcytosine] CTD PMID:24214992 NCBI chr20:25,761,042...25,840,926
Ensembl chr20:25,768,120...25,833,052 		JBrowse link
G Tet2 tet methylcytosine dioxygenase 2 multiple interactions ISO TET2 protein affects the reaction [2,3,5,6-tetrachlorohydroquinone results in increased chemical synthesis of 5-hydroxymethylcytosine]; TET2 protein affects the reaction [2,3,5,6-tetrachlorohydroquinone results in increased oxidation of 5-Methylcytosine] CTD PMID:24214992 NCBI chr 2:221,988,645...222,072,813
Ensembl chr 2:221,988,645...222,072,534 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO 2,3,5,6-tetrachlorohydroquinone results in increased expression of TNF mRNA CTD PMID:12669308 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Ttr transthyretin affects binding EXP 2,3,5,6-tetrachlorohydroquinone binds to TTR protein CTD PMID:2043046 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008 		JBrowse link
tetrachlorophenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases oxidation ISO CYP2E1 protein results in increased oxidation of tetrachlorophenol CTD PMID:7747284 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    chemical entity 19920
      molecular entity 19920
        polyatomic entity 19877
          heteroatomic molecular entity 19805
            halide 18703
              organohalogen compound 18535
                organochlorine compound 18332
                  chlorobenzenes 15072
                    tetrachlorobenzene 119
                      1,2,3,4-tetrachlorobenzene + 2
                      1,2,3,5-tetrachlorobenzene 2
                      1,2,4,5-tetrachlorobenzene + 14
                      2',3',4',5'-tetrachlorobiphenyl-3-ol 0
                      2',4',5',7'-tetrabromo-2,3,4,5-tetrachlorofluorescein 0
                      2,2',3',4,4',5,5'-Heptachloro-3-biphenylol 0
                      2,2',3,3',4',5,5'-heptachloro-4-biphenylol 0
                      2,3,3',4,4',5,5'-Heptachlorobiphenyl 15
                      2,3,3',4,4',5-Hexachlorobiphenyl 14
                      2,3,3',4,5-pentachlorobiphenyl 0
                      2,3,4,4',5-Pentachlorobiphenyl 0
                      2,3,4,5-Tetrachloro-4'-biphenylol 10
                      2,3,4,5-tetrachlorobiphenyl 1
                      2,3,5,6-tetrachloro-1,1'-biphenyl-4,4'-diol 0
                      2,3,5,6-tetrachlorobiphenyl 2
                      2-Hydroxy-2',3',4',5,5'-pentachlorobiphenyl 1
                      4,5,6,7-tetrachloro-2-benzofuran-1(3H)-one 0
                      4-Hydroxy-2,2',3,4',5,5',6-heptachlorobiphenyl 0
                      4-hydroxy-2,2',3',4',6'-pentachlorobiphenyl 0
                      chlorothalonil 76
                      phloxine O 1
                      rose bengal free acid 0
                      tecloftalam 0
                      tecnazene 0
                      tetrachlorocatechol 2
                      tetrachlorohydroquinone 10
                      tetrachlorophenol + 8
                      tetrachlorophthalic anhydride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19805
                        carbon group molecular entity 19805
                          organic molecular entity 19775
                            organic molecule 19755
                              organic cyclic compound 19545
                                organic aromatic compound 19380
                                  benzenoid aromatic compound 18046
                                    benzenes 17911
                                      chlorobenzenes 15072
                                        tetrachlorobenzene 119
                                          1,2,3,4-tetrachlorobenzene + 2
                                          1,2,3,5-tetrachlorobenzene 2
                                          1,2,4,5-tetrachlorobenzene + 14
                                          2',3',4',5'-tetrachlorobiphenyl-3-ol 0
                                          2',4',5',7'-tetrabromo-2,3,4,5-tetrachlorofluorescein 0
                                          2,2',3',4,4',5,5'-Heptachloro-3-biphenylol 0
                                          2,2',3,3',4',5,5'-heptachloro-4-biphenylol 0
                                          2,3,3',4,4',5,5'-Heptachlorobiphenyl 15
                                          2,3,3',4,4',5-Hexachlorobiphenyl 14
                                          2,3,3',4,5-pentachlorobiphenyl 0
                                          2,3,4,4',5-Pentachlorobiphenyl 0
                                          2,3,4,5-Tetrachloro-4'-biphenylol 10
                                          2,3,4,5-tetrachlorobiphenyl 1
                                          2,3,5,6-tetrachloro-1,1'-biphenyl-4,4'-diol 0
                                          2,3,5,6-tetrachlorobiphenyl 2
                                          2-Hydroxy-2',3',4',5,5'-pentachlorobiphenyl 1
                                          4,5,6,7-tetrachloro-2-benzofuran-1(3H)-one 0
                                          4-Hydroxy-2,2',3,4',5,5',6-heptachlorobiphenyl 0
                                          4-hydroxy-2,2',3',4',6'-pentachlorobiphenyl 0
                                          chlorothalonil 76
                                          phloxine O 1
                                          rose bengal free acid 0
                                          tecloftalam 0
                                          tecnazene 0
                                          tetrachlorocatechol 2
                                          tetrachlorohydroquinone 10
                                          tetrachlorophenol + 8
                                          tetrachlorophthalic anhydride 0
paths to the root