Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:terpene alkaloid
go back to main search page
Accession:CHEBI:26871 term browser browse the term
Synonyms:related_synonym: terpene alkaloids


show annotations for term's descendants           Sort by:
 
aconitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases response to substance
multiple interactions
affects response to substance
affects transport
ISO ABCB1 results in decreased susceptibility to Aconitine
ABCB1A gene mutant form promotes the reaction [Aconitine results in increased expression of S100B protein]; ABCB1A gene mutant form results in decreased metabolism of and results in increased abundance of Aconitine
ABCB1A gene mutant form affects the susceptibility to Aconitine
ABCB1 affects the transport of Aconitine
CTD PMID:23562926, PMID:28193520 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Aconitine results in increased expression of BAX protein CTD PMID:24840785 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP Aconitine results in decreased expression of BCL2 protein CTD PMID:24840785 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases expression EXP Aconitine results in increased expression of CASP3 protein CTD PMID:24840785 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases expression EXP Aconitine results in increased expression of CASP9 protein CTD PMID:24840785 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 increases expression ISO Aconitine results in increased expression of CSNK2A1 protein CTD PMID:32234357 NCBI chr 3:147,713,808...147,760,375
Ensembl chr 3:147,713,821...147,757,862
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression EXP Aconitine results in decreased expression of CYP17A1 mRNA CTD PMID:31499053 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [Fluvoxamine results in decreased activity of CYP1A2 protein] which results in increased chemical synthesis of Aconitine metabolite CTD PMID:21277363 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions ISO [Omeprazole results in decreased activity of CYP2C19 protein] which results in decreased chemical synthesis of Aconitine metabolite CTD PMID:21277363 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases metabolic processing
multiple interactions
ISO CYP2C8 protein results in increased metabolism of Aconitine
[Gemfibrozil results in decreased activity of CYP2C8 protein] which affects the chemical synthesis of Aconitine metabolite
CTD PMID:21277363 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
multiple interactions
ISO CYP2D6 protein results in increased metabolism of Aconitine
[CYP2D6 protein results in increased metabolism of Aconitine] which results in increased chemical synthesis of 16-O-demethylaconitine; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of Aconitine metabolite
CTD PMID:21277363 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases metabolic processing
multiple interactions
ISO CYP3A5 protein results in increased metabolism of Aconitine
[CYP3A5 protein results in increased metabolism of Aconitine] which results in increased chemical synthesis of 16-O-demethylaconitine
CTD PMID:21277363 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Ep300 E1A binding protein p300 affects expression
multiple interactions
ISO Aconitine affects the expression of EP300 protein
crenigacestat affects the reaction [Aconitine affects the expression of EP300 protein]
CTD PMID:32234357 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G Hcn4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 multiple interactions
increases expression
affects expression
ISO
EXP
Aconitine promotes the reaction [NOTCH1 protein modified form binds to HCN4 promoter]
Aconitine results in increased expression of HCN4 mRNA
Aconitine affects the reaction [NOTCH1 protein modified form binds to HCN4 promoter]; crenigacestat affects the reaction [Aconitine affects the expression of HCN4 protein]
Aconitine affects the expression of HCN4 mRNA; Aconitine affects the expression of HCN4 protein
CTD PMID:32234357 NCBI chr 8:63,599,907...63,637,327
Ensembl chr 8:63,600,663...63,639,654
JBrowse link
G Hes1 hes family bHLH transcription factor 1 increases expression
multiple interactions
ISO
EXP
Aconitine results in increased expression of HES1 protein
crenigacestat inhibits the reaction [Aconitine results in increased expression of HES1 protein]
CTD PMID:32234357 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 decreases expression EXP Aconitine results in decreased expression of HSD17B3 mRNA CTD PMID:31499053 NCBI chr17:1,579,319...1,610,745
Ensembl chr17:1,579,319...1,610,745
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression EXP Aconitine results in decreased expression of HSD3B1 mRNA CTD PMID:31499053
G Kdm5a lysine demethylase 5A increases expression
multiple interactions
ISO Aconitine results in increased expression of KDM5A protein
Aconitine promotes the reaction [NOTCH1 protein modified form binds to KDM5A protein]; crenigacestat inhibits the reaction [Aconitine results in increased expression of KDM5A protein]
CTD PMID:32234357 NCBI chr 4:152,892,388...152,972,196
Ensembl chr 4:152,892,388...152,972,201
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Aconitine results in increased expression of and results in increased phosphorylation of MAPK1 protein CTD PMID:24840785 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Aconitine results in increased expression of and results in increased phosphorylation of MAPK3 protein CTD PMID:24840785 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO
EXP
Aconitine results in increased expression of MYC protein CTD PMID:32234357 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Notch1 notch receptor 1 increases expression
multiple interactions
affects expression
EXP
ISO
Aconitine results in increased expression of NOTCH1 protein; Aconitine results in increased expression of NOTCH1 protein modified form
Aconitine promotes the reaction [NOTCH1 protein modified form binds to HCN4 promoter]; Aconitine promotes the reaction [NOTCH1 protein modified form binds to KDM5A protein]; crenigacestat affects the reaction [Aconitine affects the expression of NOTCH1 protein]; crenigacestat inhibits the reaction [Aconitine results in increased expression of NOTCH1 protein modified form]
Aconitine affects the reaction [NOTCH1 protein modified form binds to HCN4 promoter]; crenigacestat inhibits the reaction [Aconitine results in increased expression of NOTCH1 protein modified form]
CTD PMID:32234357 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO Aconitine analog inhibits the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]] CTD PMID:16862215 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO Aconitine analog inhibits the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]] CTD PMID:16862215 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 increases expression EXP Aconitine results in increased expression of RPS6KB1 mRNA CTD PMID:28099878 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G S100b S100 calcium binding protein B increases expression
multiple interactions
ISO Aconitine results in increased expression of S100B protein
ABCB1A gene mutant form promotes the reaction [Aconitine results in increased expression of S100B protein]
CTD PMID:28193520 NCBI chr20:13,130,633...13,142,856
Ensembl chr20:13,130,636...13,142,856
JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression EXP Aconitine results in decreased expression of SCARB1 mRNA CTD PMID:31499053 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Aconitine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium] CTD PMID:23770354 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Tp53 tumor protein p53 increases expression EXP Aconitine results in increased expression of TP53 protein CTD PMID:24840785 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions EXP TRPA1 results in increased susceptibility to [Vehicle Emissions co-treated with Aconitine] CTD PMID:21377951 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
benzoylaconine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
multiple interactions
ISO ABCB1 protein results in increased transport of benzoylaconine
[Cyclosporine results in decreased activity of ABCB1 protein] which results in decreased transport of benzoylaconine; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of benzoylaconine
CTD PMID:23200901 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of benzoylaconine CTD PMID:23200901 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
benzoylhypaconine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases transport
ISO [Cyclosporine results in decreased activity of ABCB1 protein] which results in decreased transport of benzoylhypaconine; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of benzoylhypaconine
ABCB1 protein results in increased transport of benzoylhypaconine
CTD PMID:23200901 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of benzoylhypaconine CTD PMID:23200901 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] which results in decreased transport of benzoylhypaconine CTD PMID:23200901 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
benzoylmesaconine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
multiple interactions
ISO ABCB1 protein results in increased transport of benzoylmesaconine
[Cyclosporine results in decreased activity of ABCB1 protein] which results in decreased transport of benzoylmesaconine; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of benzoylmesaconine
CTD PMID:23200901 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of benzoylmesaconine CTD PMID:23200901 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
huperzine A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases transport
ISO ABCB1A gene mutant form affects the transport of and results in increased abundance of huperzine A
ABCB1 protein results in increased transport of huperzine A
Elacridar inhibits the reaction [ABCB1 protein results in increased transport of huperzine A]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of huperzine A]
CTD PMID:28587984 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ache acetylcholinesterase decreases activity
multiple interactions
ISO
EXP
huperzine A results in decreased activity of ACHE protein
huperzine A binds to and results in decreased activity of ACHE protein
ALB protein affects the reaction [huperzine A results in decreased activity of ACHE protein]; huperzine A inhibits the reaction [ACHE protein results in increased hydrolysis of Butyrylthiocholine]
[huperzine A co-treated with tetramethylpyrazine] results in decreased activity of ACHE protein
CTD PMID:15135892, PMID:15652380, PMID:17309523, PMID:18572153, PMID:18573242, PMID:19345205, PMID:20624417, PMID:22407886, PMID:26902639, PMID:27238725 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Alb albumin multiple interactions ISO ALB protein affects the reaction [huperzine A results in decreased activity of ACHE protein] CTD PMID:26902639 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing EXP CYP1A2 protein results in increased metabolism of huperzine A CTD PMID:12586202 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing EXP CYP3A2 protein results in increased metabolism of huperzine A CTD PMID:12586202 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases metabolic processing EXP CYP3A23-3A1 protein results in increased metabolism of huperzine A CTD PMID:12586202 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP huperzine A inhibits the reaction [Acetic Acid results in increased expression of IL1B protein] CTD PMID:23810507 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP huperzine A inhibits the reaction [Acetic Acid results in increased expression of RELA protein] CTD PMID:23810507 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP huperzine A inhibits the reaction [Acetic Acid results in increased expression of TNF protein] CTD PMID:23810507 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
methyllycaconitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO AKT1 mutant form inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]; methyllycaconitine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of and results in increased activity of AKT1 protein]
methyllycaconitine results in increased phosphorylation of AKT1 protein
CTD PMID:12511591, PMID:24012499 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G App amyloid beta precursor protein multiple interactions
decreases secretion
ISO
EXP
methyllycaconitine inhibits the reaction [Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]]; methyllycaconitine inhibits the reaction [N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]]
[APP protein co-treated with methyllycaconitine] results in decreased secretion of APP protein
methyllycaconitine results in decreased secretion of APP protein
CTD PMID:25881725, PMID:29341888 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO methyllycaconitine inhibits the reaction [Nicotine results in increased secretion of BDNF protein] CTD PMID:16790237 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO methyllycaconitine inhibits the reaction [Varenicline results in increased expression of CD36 mRNA]; methyllycaconitine inhibits the reaction [Varenicline results in increased expression of CD36 protein] CTD PMID:28202387 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cdh5 cadherin 5 multiple interactions ISO methyllycaconitine inhibits the reaction [Varenicline results in decreased expression of CDH5] CTD PMID:28842382 NCBI chr19:1,025,122...1,074,333
Ensembl chr19:1,023,683...1,074,365
JBrowse link
G Chat choline O-acetyltransferase multiple interactions ISO methyllycaconitine inhibits the reaction [SLURP1 protein results in increased expression of CHAT] CTD PMID:24365495 NCBI chr16:8,576,858...8,686,131
Ensembl chr16:8,577,840...8,686,131
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit affects response to substance ISO CHRNA3 protein affects the susceptibility to methyllycaconitine CTD PMID:19098233 NCBI chr 8:59,594,007...59,607,122
Ensembl chr 8:59,592,403...59,607,275
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions
affects activity
ISO
EXP
Carbachol inhibits the reaction [methyllycaconitine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; methyllycaconitine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; methyllycaconitine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; methyllycaconitine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
methyllycaconitine affects the activity of CHRNA4 protein
CTD PMID:14645658, PMID:19047205 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit affects response to substance ISO CHRNA5 protein affects the susceptibility to methyllycaconitine CTD PMID:19098233 NCBI chr 8:59,561,817...59,590,172
Ensembl chr 8:59,561,721...59,590,172
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions
affects response to substance
affects binding
ISO
EXP
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased abundance of Epinephrine]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of DBH mRNA]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of TH mRNA]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased expression of ITGA2B mRNA; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased expression of ITGA2B protein; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased expression of ITGB3 mRNA; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased expression of ITGB3 protein; [methyllycaconitine binds to and results in increased activity of CHRNA7 protein] which results in increased transport of Calcium; methyllycaconitine binds to and results in decreased activity of CHRNA7 protein; methyllycaconitine binds to and results in increased activity of CHRNA7 protein; methyllycaconitine inhibits the reaction [[[1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea affects the activity of CHRNA7 protein] co-treated with [PNU-282987 binds to and results in increased activity of CHRNA7 protein]] results in increased uptake of Calcium]; methyllycaconitine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]; methyllycaconitine inhibits the reaction [Choline results in increased activity of CHRNA7 protein]; methyllycaconitine inhibits the reaction [epibatidine binds to CHRNA7 protein]; methyllycaconitine inhibits the reaction [Nicotine binds to and results in increased activity of CHRNA7 protein]; methyllycaconitine inhibits the reaction [PNU-282987 binds to and results in increased activity of CHRNA7 protein]; methyllycaconitine inhibits the reaction [pozanicline binds to and results in increased activity of CHRNA7 protein]; methyllycaconitine promotes the reaction [[Nicotine results in increased activity of CHRNA7 protein] which results in increased transport of Calcium]
CHRNA7 protein affects the susceptibility to methyllycaconitine
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to Nicotine; methyllycaconitine binds to and results in decreased activity of CHRNA7 protein; methyllycaconitine inhibits the reaction [Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]]; methyllycaconitine inhibits the reaction [N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]]
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which affects the susceptibility to Nicotine; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to bis(12)-hupyridone; methyllycaconitine binds to and results in decreased activity of CHRNA7 protein; methyllycaconitine inhibits the reaction [[3-(4-hydroxy-2-methoxybenzylidene)anabaseine co-treated with 5-hydroxyindole] results in increased activity of CHRNA7 protein]; methyllycaconitine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; methyllycaconitine inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]; methyllycaconitine inhibits the reaction [Melitten results in increased activity of CHRNA7 protein]; Nicotine inhibits the reaction [methyllycaconitine binds to CHRNA7 protein]
methyllycaconitine analog binds to CHRNA7 protein; methyllycaconitine binds to CHRNA7 protein
CTD PMID:9336329, PMID:10082212, PMID:10216184, PMID:11893908, PMID:12626641, PMID:15523001, PMID:15542623, PMID:17098430, PMID:17218065, PMID:17498763, PMID:17709503, PMID:18321476, PMID:18385335, PMID:18448488, PMID:19098233, PMID:19448648, PMID:19498423, PMID:19910175, PMID:21051662, PMID:21385097, PMID:21703337, PMID:21715663, PMID:23085120, PMID:25881725, PMID:28395994 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Chrna9 cholinergic receptor nicotinic alpha 9 subunit multiple interactions ISO methyllycaconitine binds to and results in decreased activity of CHRNA9 protein CTD PMID:25282151 NCBI chr14:43,883,450...43,890,171
Ensembl chr14:43,883,458...43,890,171
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO Carbachol inhibits the reaction [methyllycaconitine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; methyllycaconitine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; methyllycaconitine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; methyllycaconitine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14645658 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Dbh dopamine beta-hydroxylase multiple interactions ISO [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of DBH mRNA] CTD PMID:17498763 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO methyllycaconitine inhibits the reaction [N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide inhibits the reaction [Estradiol affects the expression of IL1B mRNA]] CTD PMID:27766701 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1r1 interleukin 1 receptor type 1 multiple interactions EXP methyllycaconitine affects the reaction [Nicotine results in increased expression of IL1R1 mRNA]; methyllycaconitine affects the reaction [Nicotine results in increased expression of IL1R1 protein] CTD PMID:27180639 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
JBrowse link
G Il6 interleukin 6 increases expression ISO methyllycaconitine results in increased expression of IL6 protein CTD PMID:25396421 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itga2b integrin subunit alpha 2b multiple interactions ISO [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased expression of ITGA2B mRNA; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased expression of ITGA2B protein CTD PMID:21385097 NCBI chr10:90,397,960...90,416,550
Ensembl chr10:90,398,132...90,415,070
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO methyllycaconitine inhibits the reaction [4-naphthalene-1-yl-3a,4,5,9b-tetrahydro-3-H-cyclopenta(c)quinoline-8-sulfonic acid amide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of ITGAM mRNA]] CTD PMID:28867753 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased expression of ITGB3 mRNA; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased expression of ITGB3 protein CTD PMID:21385097 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; MAPK1 mutant form inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]; methyllycaconitine inhibits the reaction [Varenicline results in increased phosphorylation of MAPK1 protein]
methyllycaconitine results in increased phosphorylation of MAPK1 protein
CTD PMID:18448488, PMID:24012499, PMID:28202387, PMID:28842382 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; MAPK3 mutant form inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]; methyllycaconitine inhibits the reaction [Varenicline results in increased phosphorylation of MAPK3 protein]
methyllycaconitine results in increased phosphorylation of MAPK3 protein
CTD PMID:18448488, PMID:24012499, PMID:28202387, PMID:28842382 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate increases phosphorylation ISO methyllycaconitine results in increased phosphorylation of MARCKS protein CTD PMID:24012499 NCBI chr20:42,966,140...42,971,838
Ensembl chr20:42,966,140...42,971,838
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions EXP methyllycaconitine inhibits the reaction [[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of MKI67 protein] CTD PMID:29501575 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mtor mechanistic target of rapamycin kinase increases phosphorylation
multiple interactions
ISO methyllycaconitine results in increased phosphorylation of MTOR protein
MTOR mutant form inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]
CTD PMID:24012499 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP methyllycaconitine analog inhibits the reaction [Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]] CTD PMID:27984197 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO methyllycaconitine inhibits the reaction [4-naphthalene-1-yl-3a,4,5,9b-tetrahydro-3-H-cyclopenta(c)quinoline-8-sulfonic acid amide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NFKBIA mRNA]] CTD PMID:28867753 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions ISO methyllycaconitine inhibits the reaction [Nicotine results in increased expression of NTRK2 protein] CTD PMID:16790237 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 multiple interactions ISO methyllycaconitine inhibits the reaction [Varenicline results in increased expression of OLR1 mRNA]; methyllycaconitine inhibits the reaction [Varenicline results in increased expression of OLR1 protein] CTD PMID:28202387 NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
methyllycaconitine inhibits the reaction [Varenicline results in increased phosphorylation of RELA protein]
methyllycaconitine analog inhibits the reaction [Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]]
CTD PMID:27984197, PMID:28202387 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Slurp1 secreted Ly6/Plaur domain containing 1 multiple interactions ISO methyllycaconitine inhibits the reaction [SLURP1 protein results in increased abundance of Acetylcholine]; methyllycaconitine inhibits the reaction [SLURP1 protein results in increased expression of CHAT] CTD PMID:24365495 NCBI chr 7:115,961,655...115,963,071
Ensembl chr 7:115,961,731...115,963,046
JBrowse link
G Srr serine racemase multiple interactions
increases expression
ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]; [methyllycaconitine co-treated with Egtazic Acid] results in increased expression of SRR protein; AKT1 mutant form inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]; Cycloheximide inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]; MAPK1 mutant form inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]; MAPK3 mutant form inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]; MTOR mutant form inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]; Sirolimus inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]; U 0126 inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]
[methyllycaconitine co-treated with Egtazic Acid] results in increased expression of SRR protein; Cycloheximide inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]
CTD PMID:24012499 NCBI chr10:61,756,138...61,772,327
Ensembl chr10:61,756,138...61,772,293
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases phosphorylation
ISO
EXP
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]
methyllycaconitine inhibits the reaction [[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of STAT3 protein modified form]
methyllycaconitine results in decreased phosphorylation of STAT3 protein
CTD PMID:18448488, PMID:25396421, PMID:29501575 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tacr1 tachykinin receptor 1 multiple interactions EXP methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TACR1 mRNA]; methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TACR1 protein] CTD PMID:26524655 NCBI chr 4:113,247,236...113,416,139
Ensembl chr 4:113,247,795...113,414,504
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of TH mRNA] CTD PMID:17498763 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO methyllycaconitine inhibits the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF mRNA]]
methyllycaconitine results in increased expression of TNF protein
CTD PMID:21606497, PMID:25396421 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TRPV1 mRNA]; methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TRPV1 protein] CTD PMID:26524655 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Txn1 thioredoxin 1 multiple interactions EXP methyllycaconitine inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TXN1 protein]]; methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TXN1 protein] CTD PMID:28082123 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Zfp36 zinc finger protein 36 multiple interactions ISO methyllycaconitine inhibits the reaction [[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA] CTD PMID:21606497 NCBI chr 1:85,380,088...85,382,565
Ensembl chr 1:85,380,088...85,382,569
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        biochemical role 19304
          metabolite 19285
            alkaloid 5354
              terpene alkaloid 72
                diterpene alkaloid + 68
                laxiracemosin H 0
                monoterpene alkaloid + 0
                sesquiterpene alkaloid + 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    main group molecular entity 19696
                      s-block molecular entity 19456
                        hydrogen molecular entity 19447
                          hydrides 18703
                            organic hydride 18265
                              organic fundamental parent 18265
                                hydrocarbon 17986
                                  terpene 9609
                                    terpenoid 9593
                                      terpene alkaloid 72
                                        diterpene alkaloid + 68
                                        laxiracemosin H 0
                                        monoterpene alkaloid + 0
                                        sesquiterpene alkaloid + 9
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.