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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:amsacrine
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Accession:CHEBI:2687 term browser browse the term
Definition:A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
Synonyms:exact_synonym: N-[4-(acridin-9-ylamino)-3-methoxyphenyl]methanesulfonamide
 related_synonym: 4'-(9-Acridinylamino)-3'-methoxymethanesulfonanilide;   4'-(9-Acridinylamino)methanesulfon-m-anisidide;   4'-(9-Acridinylamino)methanesulfon-meta-anisidide;   4'-(9-Acridinylamino)methanesulphon-m-anisidide;   Formula=C21H19N3O3S;   InChI=1S/C21H19N3O3S/c1-27-20-13-14(24-28(2,25)26)11-12-19(20)23-21-15-7-3-5-9-17(15)22-18-10-6-4-8-16(18)21/h3-13,24H,1-2H3,(H,22,23);   InChIKey=XCPGHVQEEXUHNC-UHFFFAOYSA-N;   SMILES=COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12;   amsacrina;   amsacrinum;   mAMSA
 xref: Beilstein:500176;   CAS:51264-14-3;   DrugBank:DB00276;   Drug_Central:203;   HMDB:HMDB0014421;   KEGG:C01553;   KEGG:D02321
 xref_mesh: MESH:D000677
 xref: PMID:17675230;   PMID:9625435;   Reaxys:500176;   Wikipedia:Amsacrine



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amsacrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO Amsacrine analog binds to ALB protein; Amsacrine binds to ALB protein CTD PMID:10803926 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Ar androgen receptor multiple interactions ISO Amsacrine binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Atg7 autophagy related 7 decreases expression ISO Amsacrine results in decreased expression of ATG7 protein CTD PMID:37451322 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO ATM protein promotes the reaction [Amsacrine results in increased phosphorylation of H2AX protein] CTD PMID:37451322 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases response to substance ISO BAX protein results in increased susceptibility to Amsacrine CTD PMID:16177561 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases response to substance ISO BCL2 protein results in decreased susceptibility to Amsacrine CTD PMID:10920913 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions
ISO Amsacrine results in decreased expression of BCL2L1 protein
[[Amsacrine results in decreased phosphorylation of MAPK1 protein] which results in decreased expression of ELAVL1 mRNA] which results in increased degradation of BCL2L1 mRNA; [[Amsacrine results in decreased phosphorylation of MAPK3 protein] which results in decreased expression of ELAVL1 mRNA] which results in increased degradation of BCL2L1 mRNA; ELAVL1 protein inhibits the reaction [Amsacrine results in decreased expression of BCL2L1 mRNA]; ELAVL1 protein inhibits the reaction [Amsacrine results in increased degradation of BCL2L1 mRNA]
CTD PMID:37451322 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Becn1 beclin 1 increases expression ISO Amsacrine results in increased expression of BECN1 protein CTD PMID:37451322 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Casp2 caspase 2 increases splicing
increases expression
ISO Amsacrine results in increased splicing of CASP2 mRNA
Amsacrine results in increased expression of CASP2 mRNA alternative form
CTD PMID:14757846 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Ccna2 cyclin A2 multiple interactions ISO Amsacrine results in increased degradation of and results in decreased expression of CCNA2 protein CTD PMID:11774253 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO Amsacrine results in increased degradation of and results in decreased expression of CCNB1 protein CTD PMID:11774253 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccne1 cyclin E1 increases expression ISO Amsacrine results in increased expression of CCNE1 protein CTD PMID:11774253 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Egf epidermal growth factor multiple interactions ISO [EGF protein results in decreased expression of TOP2A protein] which results in decreased susceptibility to Amsacrine CTD PMID:16969495 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Elavl1 ELAV like RNA binding protein 1 decreases expression
multiple interactions
ISO Amsacrine results in decreased expression of ELAVL1 protein
[[Amsacrine results in decreased phosphorylation of MAPK1 protein] which results in decreased expression of ELAVL1 mRNA] which results in increased degradation of BCL2L1 mRNA; [[Amsacrine results in decreased phosphorylation of MAPK3 protein] which results in decreased expression of ELAVL1 mRNA] which results in increased degradation of BCL2L1 mRNA; [Amsacrine results in increased expression of MIR22] which results in decreased expression of ELAVL1 mRNA; Amsacrine results in decreased expression of and results in decreased stability of ELAVL1 mRNA; ELAVL1 protein inhibits the reaction [Amsacrine results in decreased expression of BCL2L1 mRNA]; ELAVL1 protein inhibits the reaction [Amsacrine results in increased degradation of BCL2L1 mRNA]; GLX351322 inhibits the reaction [Amsacrine results in decreased expression of ELAVL1 protein]
CTD PMID:37451322 NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Amsacrine binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G H2ax H2A.X variant histone increases phosphorylation
multiple interactions
ISO Amsacrine results in increased phosphorylation of H2AX protein
ATM protein promotes the reaction [Amsacrine results in increased phosphorylation of H2AX protein]
CTD PMID:37451322 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO Amsacrine binds to and results in decreased activity of KCNH2 protein CTD PMID:15148258 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression ISO Amsacrine results in increased expression of MAP1LC3B protein CTD PMID:37451322 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO MAP2K1 protein inhibits the reaction [Amsacrine results in decreased phosphorylation of MAPK1 protein]; MAP2K1 protein inhibits the reaction [Amsacrine results in decreased phosphorylation of MAPK3 protein]; MAP2K1 protein inhibits the reaction [Amsacrine results in increased expression of MIR22 protein] CTD PMID:37451322 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO [[Amsacrine results in decreased phosphorylation of MAPK1 protein] which results in decreased expression of ELAVL1 mRNA] which results in increased degradation of BCL2L1 mRNA; GLX351322 inhibits the reaction [Amsacrine results in decreased phosphorylation of MAPK1 protein]; MAP2K1 protein inhibits the reaction [Amsacrine results in decreased phosphorylation of MAPK1 protein]; MitoTEMPO inhibits the reaction [Amsacrine results in decreased phosphorylation of MAPK1 protein] CTD PMID:37451322 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk12 mitogen-activated protein kinase 12 increases activity
multiple interactions
affects response to substance
ISO Amsacrine results in increased activity of MAPK12 protein
[MAPK12 protein results in increased phosphorylation of TOP2A protein] which results in increased susceptibility to Amsacrine; [MAPK12 protein results in increased stability of TOP2A protein] which results in increased susceptibility to Amsacrine
MAPK12 protein affects the susceptibility to Amsacrine
CTD PMID:21878638 NCBI chr 7:120,206,005...120,216,711
Ensembl chr 7:120,206,271...120,216,664
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
ISO Amsacrine results in decreased phosphorylation of MAPK3 protein
[[Amsacrine results in decreased phosphorylation of MAPK3 protein] which results in decreased expression of ELAVL1 mRNA] which results in increased degradation of BCL2L1 mRNA; GLX351322 inhibits the reaction [Amsacrine results in decreased phosphorylation of MAPK3 protein]; MAP2K1 protein inhibits the reaction [Amsacrine results in decreased phosphorylation of MAPK3 protein]; MitoTEMPO inhibits the reaction [Amsacrine results in decreased phosphorylation of MAPK3 protein]
CTD PMID:37451322 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mdm2 MDM2 proto-oncogene decreases response to substance ISO MDM2 promoter SNP results in decreased susceptibility to Amsacrine CTD PMID:17575151 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Mir22 microRNA 22 increases expression
multiple interactions
ISO Amsacrine results in increased expression of MIR22
[Amsacrine results in increased expression of MIR22] which results in decreased expression of ELAVL1 mRNA; MAP2K1 protein inhibits the reaction [Amsacrine results in increased expression of MIR22 protein]
CTD PMID:37451322 NCBI chr10:60,307,039...60,307,133
Ensembl chr10:60,307,039...60,307,133
JBrowse link
G Mir25 microRNA 25 decreases expression
multiple interactions
ISO Amsacrine results in decreased expression of MIR25
SIDT2 protein promotes the reaction [Amsacrine results in decreased expression of MIR25 protein]
CTD PMID:37451322 NCBI chr12:17,042,932...17,043,015
Ensembl chr12:17,042,932...17,043,015
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO Amsacrine results in decreased expression of MYC mRNA CTD PMID:11585056 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Ncl nucleolin affects response to substance ISO NCL protein affects the susceptibility to Amsacrine CTD PMID:16600179 NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136
JBrowse link
G Nox4 NADPH oxidase 4 increases expression
multiple interactions
ISO Amsacrine results in increased expression of NOX4 protein
Amsacrine results in increased expression of and results in decreased degradation of NOX4 mRNA; SIDT2 protein promotes the reaction [Amsacrine results in increased expression of NOX4 mRNA]; SIDT2 protein promotes the reaction [Amsacrine results in increased expression of NOX4 protein]
CTD PMID:37451322 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Amsacrine binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Prc1 protein regulator of cytokinesis 1 decreases expression ISO Amsacrine results in decreased expression of PRC1 mRNA CTD PMID:17374387 NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765
JBrowse link
G Rad51 RAD51 recombinase affects response to substance ISO RAD51 protein affects the susceptibility to Amsacrine CTD PMID:16600179 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
JBrowse link
G Rarb retinoic acid receptor, beta increases expression ISO Amsacrine results in increased expression of RARB mRNA alternative form CTD PMID:17608728 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
JBrowse link
G Sidt2 SID1 transmembrane family, member 2 multiple interactions
increases expression
ISO SIDT2 protein promotes the reaction [Amsacrine results in decreased expression of MIR25 protein]; SIDT2 protein promotes the reaction [Amsacrine results in increased expression of NOX4 mRNA]; SIDT2 protein promotes the reaction [Amsacrine results in increased expression of NOX4 protein]
Amsacrine results in increased expression of SIDT2 protein
CTD PMID:37451322 NCBI chr 8:46,232,379...46,248,913
Ensembl chr 8:46,232,383...46,248,700
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Amsacrine binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression ISO Amsacrine results in increased expression of TNFRSF11B mRNA CTD PMID:11459812 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression ISO Amsacrine results in decreased expression of TNFSF11 mRNA CTD PMID:11459812 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions
decreases response to substance
affects response to substance
ISO [EGF protein results in decreased expression of TOP2A protein] which results in decreased susceptibility to Amsacrine; [MAPK12 protein results in increased phosphorylation of TOP2A protein] which results in increased susceptibility to Amsacrine; [MAPK12 protein results in increased stability of TOP2A protein] which results in increased susceptibility to Amsacrine
TOP2A gene mutant form results in decreased susceptibility to Amsacrine; TOP2A protein mutant form results in decreased susceptibility to Amsacrine
TOP2A protein modified form affects the susceptibility to Amsacrine
CTD PMID:1651812 PMID:10727526 PMID:11470519 PMID:11676865 PMID:12569090 More... NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Top2b DNA topoisomerase II beta decreases response to substance ISO TOP2B protein mutant form results in decreased susceptibility to Amsacrine CTD PMID:15322234 PMID:16239602 PMID:16549872 NCBI chr15:9,051,340...9,111,721
Ensembl chr15:9,051,341...9,112,085
JBrowse link
G Tp53 tumor protein p53 increases activity
increases expression
multiple interactions
increases glutathionylation
ISO Amsacrine analog results in increased activity of TP53 protein
Amsacrine results in increased expression of TP53 protein
Amsacrine results in increased stability of and results in increased activity of TP53 protein
Amsacrine results in increased glutathionylation of TP53 protein
CTD PMID:11774253 PMID:12082016 PMID:16177561 PMID:17555331 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 increases expression ISO Amsacrine results in increased expression of TP53I3 mRNA CTD PMID:17374387 NCBI chr 6:27,818,327...27,825,753 JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C decreases expression ISO Amsacrine results in decreased expression of UBE2C mRNA CTD PMID:17374387 NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
JBrowse link
G Wrn WRN RecQ like helicase increases response to substance ISO WRN gene mutant form results in increased susceptibility to Amsacrine CTD PMID:10725663 NCBI chr16:58,763,517...58,898,604
Ensembl chr16:58,763,504...58,895,450
JBrowse link

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