CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: sulfur atom
Accession: CHEBI:26833
browse the term
Definition: A chalcogen that has formula S.
Synonyms: related_synonym: 16S; Elemental sulfur; Formula=S; InChI=1S/S; InChIKey=NINIDFKCEFEMDL-UHFFFAOYSA-N; S; SMILES=[S]; Schwefel; azufre; soufre; sulfur; sulphur; theion
xref: CAS:7704-34-9; KEGG:C00087; KEGG:D06527
xref_mesh: MESH:D013455
xref: PPDB:605; WebElements:S
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NFE2L2
NFE2 like bZIP transcription factor 2
multiple interactions
EXP
Thioctic Acid inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]
CTD
PMID:24512358
NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183
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TPO
thyroid peroxidase
decreases activity
EXP
captax results in decreased activity of TPO protein
CTD
PMID:23959146 PMID:25953703
NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,409,208
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IL6
interleukin 6
multiple interactions
EXP
2,4-thiazolidinedione inhibits the reaction [Linoleic Acid results in increased expression of IL6 protein]; [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]]
CTD
PMID:14519784 PMID:15226458
NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
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PPARG
peroxisome proliferator activated receptor gamma
multiple interactions
EXP
2,4-thiazolidinedione binds to and results in increased activity of PPARG protein
CTD
PMID:14519784
NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944
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RELA
RELA proto-oncogene, NF-kB subunit
multiple interactions
EXP
2,4-thiazolidinedione inhibits the reaction [Linoleic Acid results in increased activity of RELA protein]
CTD
PMID:14519784
NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469
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TNF
tumor necrosis factor
multiple interactions
EXP
[2,4-thiazolidinedione co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]]; [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA]]
CTD
PMID:15226458
NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
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VCAM1
vascular cell adhesion molecule 1
multiple interactions
EXP
[Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA]]
CTD
PMID:15226458
NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,920...117,511,222
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ALDH7A1
aldehyde dehydrogenase 7 family member A1
multiple interactions
EXP
Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of ALDH7A1 protein]
CTD
PMID:21296058
NCBI chr 2:129,663,226...129,709,728
Ensembl chr 2:129,662,969...129,709,705
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HSPA5
heat shock protein family A (Hsp70) member 5
increases expression
EXP
Dithiothreitol metabolite results in increased expression of HSPA5 protein
CTD
PMID:17416481
NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
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IDH2
isocitrate dehydrogenase (NADP(+)) 2
multiple interactions
EXP
Dithiothreitol inhibits the reaction [Cadmium Chloride results in decreased activity of IDH2 protein]; Dithiothreitol inhibits the reaction [Cadmium results in decreased activity of IDH2 protein]
CTD
PMID:16785314
NCBI chr 7:55,654,298...55,675,571
Ensembl chr 7:55,651,609...55,675,554
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FOS
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
EXP
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA]
CTD
PMID:7564105
NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
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ALOX5AP
arachidonate 5-lipoxygenase activating protein
multiple interactions
EXP
MK-886 inhibits the reaction [aristolochic acid I results in increased expression of ALOX5AP protein]
CTD
PMID:21658425
NCBI chr11:7,371,328...7,438,111
Ensembl chr11:7,411,644...7,438,108
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CASP3
caspase 3
multiple interactions
EXP
MK-886 inhibits the reaction [aristolochic acid I results in increased cleavage of and results in increased activity of CASP3 protein]
CTD
PMID:21658425
NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
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SLC4A2
solute carrier family 4 member 2
multiple interactions
EXP
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid promotes the reaction [SLC4A2 protein binds to SLC4A2 protein]
CTD
PMID:10387099
NCBI chr18:6,149,459...6,166,622
Ensembl chr18:6,149,459...6,165,212
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CYP19A3
cytochrome P450 19A3
affects expression decreases expression
EXP
bisphenol S affects the expression of CYP19A1 protein bisphenol S results in decreased expression of CYP19A1 mRNA
CTD
PMID:28352085
NCBI chr 1:120,476,890...120,556,103
Ensembl chr 1:120,367,667...120,695,899
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ESR1
estrogen receptor 1
decreases expression increases expression
EXP
bisphenol S results in decreased expression of ESR1 mRNA bisphenol S results in increased expression of ESR1 protein
CTD
PMID:28352085
NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363
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ESR2
estrogen receptor 2
increases expression decreases expression
EXP
bisphenol S results in increased expression of ESR2 protein bisphenol S results in decreased expression of ESR2 mRNA
CTD
PMID:28352085
NCBI chr 1:193,823,666...193,907,330
Ensembl chr 1:193,829,560...193,906,565
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FSHB
follicle stimulating hormone subunit beta
multiple interactions
EXP
bisphenol S inhibits the reaction [[FSHB protein co-treated with Androstenedione] results in increased chemical synthesis of and results in increased secretion of Estradiol]; bisphenol S inhibits the reaction [FSHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone]
CTD
PMID:34019995
NCBI chr 2:30,395,769...30,399,282
Ensembl chr 2:30,395,018...30,399,274
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FOS
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
EXP
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA]
CTD
PMID:7564105
NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
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TPO
thyroid peroxidase
decreases activity
EXP
Propylthiouracil results in decreased activity of TPO protein
CTD
PMID:23959146
NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,409,208
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SLCO1A2
solute carrier organic anion transporter family member 1A2
multiple interactions increases uptake
EXP
Amoxicillin inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Amoxicillin inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid] SLCO1A2 protein results in increased uptake of Amoxicillin
CTD
PMID:31287969
NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,049,443...52,129,730
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NOS3
nitric oxide synthase 3
decreases expression
EXP
amprenavir results in decreased expression of NOS3 mRNA
CTD
PMID:16123675
NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
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TPO
thyroid peroxidase
decreases activity
EXP
benzothiazole results in decreased activity of TPO protein
CTD
PMID:25953703
NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,409,208
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ADM
adrenomedullin
increases expression
EXP
Mustard Gas results in increased expression of ADM mRNA
CTD
PMID:18988085
NCBI chr 2:49,229,223...49,231,521
Ensembl chr 2:49,229,223...49,231,866
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AIF1
allograft inflammatory factor 1
increases expression
EXP
Mustard Gas results in increased expression of AIF1 mRNA
CTD
PMID:18988085
NCBI chr 7:23,711,752...23,731,191
Ensembl chr 7:23,726,787...23,731,671
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AMCF-II
alveolar macrophage-derived chemotactic factor-II
increases expression
EXP
Mustard Gas results in increased expression of CXCL5 mRNA
CTD
PMID:18988085
NCBI chr 8:70,008,225...70,010,360
Ensembl chr 8:70,008,162...70,010,358
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ANPEP
alanyl aminopeptidase, membrane
increases expression
EXP
Mustard Gas results in increased expression of ANPEP mRNA
CTD
PMID:18988085
NCBI chr 7:55,351,081...55,373,856
Ensembl chr 7:55,351,087...55,373,881
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ANXA1
annexin A1
increases expression
EXP
Mustard Gas results in increased expression of ANXA1 mRNA
CTD
PMID:18988085
NCBI chr 1:226,414,200...226,431,963
Ensembl chr 1:226,414,306...226,432,279
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ARG1
arginase 1
increases expression
EXP
Mustard Gas results in increased expression of ARG1 mRNA
CTD
PMID:18988085
NCBI chr 1:32,006,035...32,028,983
Ensembl chr 1:32,006,046...32,028,988
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ATF2
activating transcription factor 2
affects expression
EXP
Mustard Gas affects the expression of ATF2 mRNA
CTD
PMID:18988085
NCBI chr15:80,984,969...81,076,573
Ensembl chr15:80,985,126...81,081,014
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BCL2
BCL2 apoptosis regulator
decreases expression
EXP
Mustard Gas results in decreased expression of BCL2 protein
CTD
PMID:9302645
NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879
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BIRC6
baculoviral IAP repeat containing 6
increases expression
EXP
Mustard Gas results in increased expression of BIRC6 mRNA
CTD
PMID:18988085
NCBI chr 3:107,012,967...107,269,370
Ensembl chr 3:107,012,986...107,269,477
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BMP5
bone morphogenetic protein 5
decreases expression
EXP
Mustard Gas results in decreased expression of BMP5 mRNA
CTD
PMID:18988085
NCBI chr 7:25,344,924...25,468,430
Ensembl chr 7:25,344,822...25,470,470
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C2
complement C2
increases expression
EXP
Mustard Gas results in increased expression of C2 mRNA
CTD
PMID:18988085
NCBI chr 7:24,020,590...24,034,042
Ensembl chr 7:23,995,982...24,033,930
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C3
complement C3
increases expression
EXP
Mustard Gas results in increased expression of C3 mRNA
CTD
PMID:18988085
NCBI chr 2:72,431,470...72,471,622
Ensembl chr 2:72,431,212...72,472,228
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C7
complement C7
increases expression
EXP
Mustard Gas results in increased expression of C7 mRNA
CTD
PMID:18988085
NCBI chr16:25,846,860...25,902,707
Ensembl chr16:25,846,860...25,903,980
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CAPNS1
calpain small subunit 1
increases expression
EXP
Mustard Gas results in increased expression of CAPNS1 mRNA
CTD
PMID:18988085
NCBI chr 6:45,511,410...45,518,610
Ensembl chr 6:45,511,295...45,518,610
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CASP3
caspase 3
increases expression
EXP
Mustard Gas results in increased expression of CASP3 mRNA
CTD
PMID:18988085
NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
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CCL19
C-C motif chemokine ligand 19
increases expression
EXP
Mustard Gas results in increased expression of CCL19 mRNA
CTD
PMID:18988085
NCBI chr10:32,110,366...32,112,529
Ensembl chr10:32,110,065...32,112,734
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CCL2
chemokine (C-C motif) ligand 2
increases expression
EXP
Mustard Gas results in increased expression of CCL2 mRNA
CTD
PMID:18988085 PMID:27617619
NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026
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CCL5
C-C motif chemokine ligand 5
increases expression
EXP
Mustard Gas results in increased expression of CCL5 mRNA
CTD
PMID:18988085
NCBI chr12:39,652,731...39,659,121
Ensembl chr12:39,648,598...39,659,118
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CCN1
cellular communication network factor 1
increases expression
EXP
Mustard Gas results in increased expression of CCN1 mRNA
CTD
PMID:27617619
NCBI chr 4:130,392,404...130,395,179
Ensembl chr 4:130,392,407...130,395,150
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CCN2
cellular communication network factor 2
increases expression
EXP
Mustard Gas results in increased expression of CCN2 mRNA
CTD
PMID:27617619
NCBI chr 1:31,674,398...31,677,697
Ensembl chr 1:31,674,394...31,677,691
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CCR1
C-C motif chemokine receptor 1
increases expression
EXP
Mustard Gas results in increased expression of CCR1 mRNA
CTD
PMID:18988085
NCBI chr13:29,227,218...29,233,862
Ensembl chr13:29,227,222...29,233,960
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CCR5
C-C motif chemokine receptor 5
decreases expression
EXP
Mustard Gas results in decreased expression of CCR5 mRNA
CTD
PMID:27617619
NCBI chr13:29,382,383...29,387,902
Ensembl chr13:29,383,303...29,387,895
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CDKN1A
cyclin dependent kinase inhibitor 1A
increases expression
EXP
Mustard Gas results in increased expression of CDKN1A mRNA
CTD
PMID:27617619
NCBI chr 7:32,354,776...32,363,771
Ensembl chr 7:32,359,455...32,363,761
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CFB
complement factor B
increases expression
EXP
Mustard Gas results in increased expression of BF mRNA
CTD
PMID:18988085
NCBI chr 7:24,034,077...24,040,523
Ensembl chr 7:24,033,740...24,041,179
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CLDN1
claudin 1
decreases expression
EXP
Mustard Gas results in decreased expression of CLDN1 mRNA
CTD
PMID:18988085
NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657
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CLU
clusterin
increases expression
EXP
Mustard Gas results in increased expression of CLU mRNA
CTD
PMID:18988085
NCBI chr14:11,336,585...11,352,569
Ensembl chr14:11,336,595...11,349,764
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CTNNA3
catenin alpha 3
decreases expression
EXP
Mustard Gas results in decreased expression of CTNNA3 mRNA
CTD
PMID:18988085
NCBI chr14:69,195,231...70,974,543
Ensembl chr14:69,195,961...70,938,204
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CXCL2
chemokine (C-X-C motif) ligand 2
increases expression
EXP
Mustard Gas results in increased expression of CXCL2 mRNA
CTD
PMID:18988085
NCBI chr 8:70,157,253...70,159,145
Ensembl chr 8:70,157,214...70,159,138
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CXCL8
C-X-C motif chemokine ligand 8
increases expression
EXP
Mustard Gas results in increased expression of CXCL8 mRNA
CTD
PMID:12481301 PMID:18988085 PMID:27617619
NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
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CXCR4
C-X-C motif chemokine receptor 4
increases expression
EXP
Mustard Gas results in increased expression of CXCR4 mRNA
CTD
PMID:18988085
NCBI chr15:15,663,652...15,666,706
Ensembl chr15:15,663,494...15,667,232
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EGR1
early growth response 1
increases expression
EXP
Mustard Gas results in increased expression of EGR1 mRNA
CTD
PMID:18988085 PMID:27617619
NCBI chr 2:140,440,829...140,445,302
Ensembl chr 2:140,441,421...140,445,296
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EPHA4
EPH receptor A4
decreases expression
EXP
Mustard Gas results in decreased expression of EPHA4 mRNA
CTD
PMID:18988085
NCBI chr15:123,350,867...123,501,872
Ensembl chr15:123,352,816...123,503,126
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FBXO32
F-box protein 32
decreases expression
EXP
Mustard Gas results in decreased expression of FBXO32 mRNA
CTD
PMID:27617619
NCBI chr 4:15,895,875...15,925,929
Ensembl chr 4:15,895,689...15,930,931
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FCN2
ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)
increases expression
EXP
Mustard Gas results in increased expression of FCNB mRNA
CTD
PMID:18988085
NCBI chr 1:274,106,276...274,111,970
Ensembl chr 1:274,103,877...274,111,970
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FGF2
fibroblast growth factor 2
increases expression
EXP
Mustard Gas results in increased expression of FGF2 mRNA
CTD
PMID:27617619
NCBI chr 8:101,278,877...101,344,084
Ensembl chr 8:101,278,885...101,343,916
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FGFR2
fibroblast growth factor receptor 2
decreases expression
EXP
Mustard Gas results in decreased expression of FGFR2 mRNA
CTD
PMID:18988085
NCBI chr14:131,183,095...131,285,001
Ensembl chr14:131,181,713...131,289,425
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FOS
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression
EXP
Mustard Gas results in increased expression of FOS mRNA
CTD
PMID:18988085 PMID:27617619
NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
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FXYD3
FXYD domain containing ion transport regulator 3
decreases expression
EXP
Mustard Gas results in decreased expression of FXYD3 mRNA
CTD
PMID:18988085
NCBI chr 6:44,647,771...44,654,377
Ensembl chr 6:44,647,466...44,654,374
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GADD45A
growth arrest and DNA damage inducible alpha
increases expression
EXP
Mustard Gas results in increased expression of GADD45A mRNA
CTD
PMID:18988085
NCBI chr 6:144,940,702...144,944,089
Ensembl chr 6:144,940,697...144,944,089
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GAPDH
glyceraldehyde-3-phosphate dehydrogenase
increases expression
EXP
Mustard Gas results in increased expression of GAPDH mRNA
CTD
PMID:18988085
NCBI chr 5:64,129,678...64,135,194
Ensembl chr 5:64,129,679...64,133,991
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GUCY1B1
guanylate cyclase 1 soluble subunit beta 1
increases expression
EXP
Mustard Gas results in increased expression of GUCY1B1 mRNA
CTD
PMID:18988085
NCBI chr 8:44,544,364...44,604,690
Ensembl chr 8:44,544,179...44,604,687
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HBEGF
heparin binding EGF like growth factor
increases expression
EXP
Mustard Gas results in increased expression of HBEGF mRNA
CTD
PMID:27617619
NCBI chr 2:142,102,455...142,115,192
Ensembl chr 2:142,102,458...142,115,174
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HMOX1
heme oxygenase 1
increases expression
EXP
Mustard Gas results in increased expression of HMOX1 mRNA
CTD
PMID:18988085
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HSPA1L
heat shock protein family A (Hsp70) member 1 like
increases expression
EXP
Mustard Gas results in increased expression of HSPA1L mRNA
CTD
PMID:18988085
NCBI chr 7:23,909,960...23,938,678
Ensembl chr 7:23,909,960...23,914,629
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ICAM1
intercellular adhesion molecule 1
increases expression
EXP
Mustard Gas results in increased expression of ICAM1 mRNA
CTD
PMID:18988085
NCBI chr 2:69,097,136...69,107,722
Ensembl chr 2:69,097,122...69,108,205
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IGF1
insulin like growth factor 1
increases expression
EXP
Mustard Gas results in increased expression of IGF1 mRNA
CTD
PMID:18988085
NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,033
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IGFBP5
insulin like growth factor binding protein 5
decreases expression
EXP
Mustard Gas results in decreased expression of IGFBP5 mRNA
CTD
PMID:18988085
NCBI chr15:118,861,816...118,877,787
Ensembl chr15:118,857,625...118,878,120
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IL1R1
interleukin 1 receptor type 1
increases expression
EXP
Mustard Gas results in increased expression of IL1R1 mRNA
CTD
PMID:18988085
NCBI chr 3:52,192,912...52,334,734
Ensembl chr 3:52,192,915...52,288,485
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IL23A
interleukin 23 subunit alpha
decreases expression
EXP
Mustard Gas results in decreased expression of IL23A mRNA
CTD
PMID:27617619
NCBI chr 5:21,732,416...21,733,981
Ensembl chr 5:21,732,165...21,734,267
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IL4R
interleukin 4 receptor
decreases expression
EXP
Mustard Gas results in decreased expression of IL4R mRNA
CTD
PMID:18988085
NCBI chr 3:19,526,343...19,576,792
Ensembl chr 3:19,523,564...19,576,544
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IL6
interleukin 6
increases expression
EXP
Mustard Gas results in increased expression of IL6 mRNA
CTD
PMID:12481301
NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
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INHCA
inhibitor of carbonic anhydrase
decreases expression
EXP
Mustard Gas results in decreased expression of PICA mRNA
CTD
PMID:18988085
NCBI chr13:74,862,502...74,907,059
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ITGA6
integrin subunit alpha 6
affects expression
EXP
Mustard Gas affects the expression of ITGA6 protein
CTD
PMID:9285538
NCBI chr15:78,504,108...78,591,779
Ensembl chr15:78,504,078...78,591,777
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ITGB2
integrin subunit beta 2
increases expression
EXP
Mustard Gas results in increased expression of ITGB2 mRNA
CTD
PMID:18988085
NCBI chr13:207,514,281...207,544,108
Ensembl chr13:207,512,950...207,544,107
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ITGB4
integrin subunit beta 4
affects expression
EXP
Mustard Gas affects the expression of ITGB4 protein
CTD
PMID:9285538
NCBI chr12:5,651,292...5,685,601
Ensembl chr12:5,651,292...5,685,611
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LAMC2
laminin subunit gamma 2
decreases expression
EXP
Mustard Gas results in decreased expression of LAMC2 protein
CTD
PMID:9302645
NCBI chr 9:124,427,545...124,499,672
Ensembl chr 9:124,435,807...124,495,351
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LDHA
lactate dehydrogenase A
increases expression
EXP
Mustard Gas results in increased expression of LDHA mRNA
CTD
PMID:18988085
NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,814,169...40,826,715
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LOC100524373
platelet factor 4
increases expression
EXP
Mustard Gas results in increased expression of PF4 mRNA
CTD
PMID:18988085
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LOC110258578
interleukin-1 beta-like
increases expression
EXP
Mustard Gas results in increased expression of IL1B mRNA
CTD
PMID:12481301
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LTF
lactotransferrin
increases expression
EXP
Mustard Gas results in increased expression of PLF mRNA
CTD
PMID:18988085
NCBI chr13:29,413,886...29,445,751
Ensembl chr13:29,413,886...29,445,739
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MMP9
matrix metallopeptidase 9
increases expression
EXP
Mustard Gas results in increased expression of MMP9 mRNA
CTD
PMID:12481301
NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,179,671...48,186,788
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MT3
metallothionein 3
decreases expression
EXP
Mustard Gas results in decreased expression of MT3 mRNA
CTD
PMID:18988085
NCBI chr 6:18,634,735...18,636,134
Ensembl chr 6:18,634,261...18,636,131
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MYC
MYC proto-oncogene, bHLH transcription factor
increases expression
EXP
Mustard Gas results in increased expression of MYC mRNA
CTD
PMID:27617619
NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,122...12,461,078
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NPPB
natriuretic peptide B
increases expression
EXP
Mustard Gas results in increased expression of NPPB mRNA
CTD
PMID:27617619
NCBI chr 6:71,930,374...71,931,843
Ensembl chr 6:71,930,382...71,932,254
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NR2F2
nuclear receptor subfamily 2 group F member 2
increases expression
EXP
Mustard Gas results in increased expression of NR2F2 mRNA
CTD
PMID:18988085
NCBI chr 7:83,076,119...83,090,250
Ensembl chr 7:83,076,124...83,090,535
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NR4A3
nuclear receptor subfamily 4 group A member 3
increases expression
EXP
Mustard Gas results in increased expression of NR4A3 mRNA
CTD
PMID:18988085
NCBI chr 1:241,569,867...241,611,735
Ensembl chr 1:241,570,010...241,611,727
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OSGIN1
oxidative stress induced growth inhibitor 1
increases expression
EXP
Mustard Gas results in increased expression of OSGIN1 mRNA
CTD
PMID:27617619
NCBI chr 6:4,642,762...4,656,113
Ensembl chr 6:4,642,764...4,653,487
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PCNA
proliferating cell nuclear antigen
increases expression
EXP
Mustard Gas results in increased expression of PCNA protein
CTD
PMID:9302645
NCBI chr17:14,137,746...14,142,584
Ensembl chr17:14,136,886...14,142,744
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PDGFRA
platelet derived growth factor receptor alpha
increases expression
EXP
Mustard Gas results in increased expression of PDGFRA mRNA
CTD
PMID:18988085
NCBI chr 8:40,966,568...41,021,440
Ensembl chr 8:40,967,493...41,021,441
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PLAU
plasminogen activator, urokinase
increases expression
EXP
Mustard Gas results in increased expression of PLAU mRNA
CTD
PMID:18988085
NCBI chr14:76,629,313...76,635,173
Ensembl chr14:76,629,299...76,635,172
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PLAUR
plasminogen activator, urokinase receptor
increases expression
EXP
Mustard Gas results in increased expression of PLAUR mRNA
CTD
PMID:18988085
NCBI chr 6:50,489,773...50,505,453
Ensembl chr 6:50,489,777...50,505,418
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POU2F3
POU class 2 homeobox 3
decreases expression
EXP
Mustard Gas results in decreased expression of POU2F3 mRNA
CTD
PMID:18988085
NCBI chr 9:47,376,852...47,458,265
Ensembl chr 9:47,376,750...47,460,165
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PPRC1
PPARG related coactivator 1
increases expression
EXP
Mustard Gas results in increased expression of PPRC1 mRNA
CTD
PMID:27617619
NCBI chr14:113,137,012...113,152,828
Ensembl chr14:113,137,037...113,152,831
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RAPGEF4
Rap guanine nucleotide exchange factor 4
decreases expression
EXP
Mustard Gas results in decreased expression of RAPGEF4 mRNA
CTD
PMID:18988085
NCBI chr15:78,773,270...79,094,490
Ensembl chr15:78,773,266...79,095,040
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RHBG
Rh family B glycoprotein
decreases expression
EXP
Mustard Gas results in decreased expression of RHBG mRNA
CTD
PMID:18988085
NCBI chr 4:93,694,259...93,708,055
Ensembl chr 4:93,694,266...93,707,865
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SCARB2
scavenger receptor class B member 2
increases expression
EXP
Mustard Gas results in increased expression of SCARB2 mRNA
CTD
PMID:18988085
NCBI chr 8:71,838,395...71,910,461
Ensembl chr 8:71,838,397...71,940,607
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SELE
selectin E
increases expression
EXP
Mustard Gas results in increased expression of SELE mRNA
CTD
PMID:18988085
NCBI chr 4:81,289,061...81,299,657
G
SERPINE1
serpin family E member 1
increases expression
EXP
Mustard Gas results in increased expression of SERPINE1 mRNA
CTD
PMID:27617619
NCBI chr 3:8,863,738...8,871,572
Ensembl chr 3:8,863,695...8,871,547
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SHAS2
hyaluronan synthase 2
increases expression
EXP
Mustard Gas results in increased expression of SHAS2 mRNA
CTD
PMID:18988085
NCBI chr 4:17,583,154...17,613,524
Ensembl chr 4:17,596,492...17,615,480
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SLC5A1
solute carrier family 5 member 1
decreases expression
EXP
Mustard Gas results in decreased expression of SLC5A1 mRNA
CTD
PMID:18988085
NCBI chr14:48,566,400...48,704,145
Ensembl chr14:48,628,224...48,705,841
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SOD2
superoxide dismutase 2
increases expression
EXP
Mustard Gas results in increased expression of SOD2 mRNA
CTD
PMID:18988085
NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560
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SPP1
secreted phosphoprotein 1
increases expression
EXP
Mustard Gas results in increased expression of SPP1 mRNA
CTD
PMID:18988085
NCBI chr 8:131,077,786...131,085,334
Ensembl chr 8:131,077,786...131,085,340
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TBXAS1
thromboxane A synthase 1
increases expression
EXP
Mustard Gas results in increased expression of TBXAS1 mRNA
CTD
PMID:18988085
NCBI chr18:9,717,291...9,886,699
Ensembl chr18:9,717,294...9,886,681
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TIMP1
TIMP metallopeptidase inhibitor 1
increases expression
EXP
Mustard Gas results in increased expression of TIMP1 mRNA
CTD
PMID:18988085
NCBI chr X:42,103,251...42,106,289
Ensembl chr X:42,102,172...42,106,296
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TLR2
toll like receptor 2
increases expression
EXP
Mustard Gas results in increased expression of TLR2 mRNA
CTD
PMID:18988085
NCBI chr 8:75,416,257...75,428,370
Ensembl chr 8:75,411,993...75,428,330
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TLR4
toll like receptor 4
increases expression
EXP
Mustard Gas results in increased expression of TLR4 mRNA
CTD
PMID:18988085
NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970
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TNC
tenascin C
increases expression
EXP
Mustard Gas results in increased expression of TNC mRNA
CTD
PMID:18988085
NCBI chr 1:255,533,235...255,630,381
Ensembl chr 1:255,533,238...255,630,376
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TNF
tumor necrosis factor
increases expression
EXP
Mustard Gas results in increased expression of TNF mRNA
CTD
PMID:12481301
NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
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TNXB
tenascin XB
decreases expression
EXP
Mustard Gas results in decreased expression of TNXB mRNA
CTD
PMID:18988085
NCBI chr 7:24,088,873...24,155,815
Ensembl chr 7:24,088,873...24,150,596
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TP53
tumor protein p53
increases expression
EXP
Mustard Gas results in increased expression of TP53 protein
CTD
PMID:9302645
NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818
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TXN
thioredoxin
increases expression
EXP
Mustard Gas results in increased expression of TXN mRNA
CTD
PMID:18988085
NCBI chr 1:251,264,180...251,278,000
Ensembl chr 1:251,263,175...251,277,988
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TYRO3
TYRO3 protein tyrosine kinase
decreases expression
EXP
Mustard Gas results in decreased expression of TYRO3 mRNA
CTD
PMID:18988085
NCBI chr 1:129,811,540...129,829,395
Ensembl chr 1:129,811,544...129,829,014
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UGP2
UDP-glucose pyrophosphorylase 2
increases expression
EXP
Mustard Gas results in increased expression of UGP2 mRNA
CTD
PMID:18988085
NCBI chr 3:77,975,450...78,032,471
Ensembl chr 3:77,975,441...78,031,703
G
VAV3
vav guanine nucleotide exchange factor 3
decreases expression
EXP
Mustard Gas results in decreased expression of VAV3 mRNA
CTD
PMID:18988085
NCBI chr 4:111,825,071...112,202,833
Ensembl chr 4:111,824,896...112,202,825
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VCAM1
vascular cell adhesion molecule 1
increases expression
EXP
Mustard Gas results in increased expression of VCAM1 mRNA
CTD
PMID:18988085
NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,920...117,511,222
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YWHAE
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
increases expression
EXP
Mustard Gas results in increased expression of YWHAE mRNA
CTD
PMID:18988085
NCBI chr12:47,601,133...47,645,327
Ensembl chr12:47,600,745...47,645,301
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TRPV1
transient receptor potential cation channel subfamily V member 1
multiple interactions
EXP
capsazepine inhibits the reaction [Sodium affects the reaction [TRPV1 protein results in increased abundance of Calcium]]
CTD
PMID:18230619
NCBI chr12:49,676,536...49,709,634
Ensembl chr12:49,677,291...49,713,977
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CAT
catalase
decreases activity
EXP
Cephaloridine results in decreased activity of CAT protein
CTD
PMID:11039594
NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
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BAX
BCL2 associated X, apoptosis regulator
increases expression
EXP
Chlorpyrifos results in increased expression of BAX mRNA
CTD
PMID:34399389
NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140
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BCL2
BCL2 apoptosis regulator
decreases expression
EXP
Chlorpyrifos results in decreased expression of BCL2 mRNA
CTD
PMID:34399389
NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879
G
CASP3
caspase 3
increases expression
EXP
Chlorpyrifos results in increased expression of CASP3 mRNA
CTD
PMID:34399389
NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
G
CAT
catalase
decreases expression
EXP
Chlorpyrifos results in decreased expression of CAT mRNA
CTD
PMID:34399389
NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
G
GPX2
glutathione peroxidase 2
decreases expression
EXP
Chlorpyrifos results in decreased expression of GPX2 mRNA
CTD
PMID:34399389
NCBI chr 7:89,007,636...89,011,620
Ensembl chr 7:89,007,375...89,011,620
G
SOD1
superoxide dismutase 1
decreases expression
EXP
Chlorpyrifos results in decreased expression of SOD1 mRNA
CTD
PMID:34399389
NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729
G
SOD2
superoxide dismutase 2
decreases expression
EXP
Chlorpyrifos results in decreased expression of SOD2 mRNA
CTD
PMID:34399389
NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560
G
APEH
acylaminoacyl-peptide hydrolase
decreases activity
EXP
chlorpyrifos-methyl results in decreased activity of APEH protein
CTD
PMID:10953051
NCBI chr13:32,205,863...32,214,517
Ensembl chr13:32,205,609...32,214,518
G
FGF10
fibroblast growth factor 10
affects binding
EXP
[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF10 protein
CTD
PMID:14699094
NCBI chr16:28,695,465...28,779,953
Ensembl chr16:28,695,470...28,777,509
G
FGF18
fibroblast growth factor 18
affects binding
EXP
[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF18 protein
CTD
PMID:14699094
NCBI chr16:52,724,867...52,760,246
Ensembl chr16:52,725,356...52,759,791
G
FGF2
fibroblast growth factor 2
affects binding
EXP
[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF2 protein
CTD
PMID:14699094
NCBI chr 8:101,278,877...101,344,084
Ensembl chr 8:101,278,885...101,343,916
G
MDK
midkine
affects binding
EXP
[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to MDK protein
CTD
PMID:14699094
NCBI chr 2:16,130,787...16,133,791
Ensembl chr 2:16,130,788...16,133,510
G
PTN
pleiotrophin
affects binding
EXP
[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to PTN protein
CTD
PMID:14699094
NCBI chr18:12,219,708...12,309,045
Ensembl chr18:12,219,787...12,309,044
G
CASP3
caspase 3
multiple interactions
EXP
Cilastatin inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]
CTD
PMID:20435919
NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
G
CASP8
caspase 8
multiple interactions
EXP
Cilastatin inhibits the reaction [Cisplatin results in increased activity of CASP8 protein]
CTD
PMID:20435919
NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468
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FASLG
Fas ligand
multiple interactions
EXP
Cilastatin inhibits the reaction [Cisplatin affects the localization of FASLG protein]
CTD
PMID:20435919
NCBI chr 9:115,068,314...115,075,147
Ensembl chr 9:115,068,090...115,076,464
G
ATOX1
antioxidant 1 copper chaperone
increases expression
EXP
Copper Sulfate results in increased expression of ATOX1 mRNA
CTD
PMID:22585802
NCBI chr16:71,299,321...71,314,598
Ensembl chr16:71,299,321...71,314,597
G
CCNB1
cyclin B1
increases secretion
EXP
Copper Sulfate results in increased secretion of CCNB1 protein
CTD
PMID:24521407
NCBI chr16:47,338,239...47,348,385
Ensembl chr16:47,338,110...47,348,377
G
COX17
cytochrome c oxidase copper chaperone COX17
decreases expression
EXP
Copper Sulfate results in decreased expression of COX17 mRNA
CTD
PMID:22585802
NCBI chr13:140,584,286...140,594,636
Ensembl chr13:140,584,363...140,587,621
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GHRH
growth hormone releasing hormone
increases expression
EXP
Copper Sulfate results in increased expression of GHRH mRNA
CTD
PMID:21110139
NCBI chr17:40,386,725...40,398,312
Ensembl chr17:40,387,344...40,397,857
G
HSP90B1
heat shock protein 90 beta family member 1
increases expression
EXP
Copper Sulfate results in increased expression of HSP90B1 mRNA
CTD
PMID:17464326
NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991
G
HSPA5
heat shock protein family A (Hsp70) member 5
increases expression
EXP
Copper Sulfate results in increased expression of HSPA5 mRNA
CTD
PMID:17464326
NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
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IGF1
insulin like growth factor 1
increases secretion
EXP
Copper Sulfate results in increased secretion of IGF1 protein
CTD
PMID:24521407
NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,033
G
SST
somatostatin
decreases expression
EXP
Copper Sulfate results in decreased expression of SST mRNA; Copper Sulfate results in decreased expression of SST protein
CTD
PMID:21110139
NCBI chr13:125,337,560...125,338,742
Ensembl chr13:125,337,418...125,338,850
G
ALB
albumin
decreases uptake
EXP
cylindrospermopsin results in decreased uptake of ALB protein
CTD
PMID:33689780
NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,721,696
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ATP1A1
ATPase Na+/K+ transporting subunit alpha 1
increases expression
EXP
cylindrospermopsin results in increased expression of ATP1A1 mRNA
CTD
PMID:33689780
NCBI chr 4:104,353,506...104,384,321
Ensembl chr 4:104,353,508...104,384,547
G
DAB2
DAB adaptor protein 2
decreases expression
EXP
cylindrospermopsin results in decreased expression of DAB2 mRNA
CTD
PMID:33689780
NCBI chr16:24,590,638...24,776,937
Ensembl chr16:24,590,645...24,646,122
G
LRP2
LDL receptor related protein 2
decreases expression
EXP
cylindrospermopsin results in decreased expression of LRP2 mRNA
CTD
PMID:33689780
NCBI chr15:75,565,299...75,754,604
Ensembl chr15:75,565,303...75,716,694
G
FMO1
flavin containing dimethylaniline monoxygenase 1
increases metabolic processing
EXP
FMO1 protein results in increased metabolism of Cysteamine
CTD
PMID:6439199
NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,868,064...63,895,076
G
FGF10
fibroblast growth factor 10
affects binding
EXP
[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF10 protein
CTD
PMID:14699094
NCBI chr16:28,695,465...28,779,953
Ensembl chr16:28,695,470...28,777,509
G
FGF18
fibroblast growth factor 18
affects binding
EXP
[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF18 protein
CTD
PMID:14699094
NCBI chr16:52,724,867...52,760,246
Ensembl chr16:52,725,356...52,759,791
G
FGF2
fibroblast growth factor 2
affects binding
EXP
[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF2 protein
CTD
PMID:14699094
NCBI chr 8:101,278,877...101,344,084
Ensembl chr 8:101,278,885...101,343,916
G
MDK
midkine
affects binding
EXP
[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to MDK protein
CTD
PMID:14699094
NCBI chr 2:16,130,787...16,133,791
Ensembl chr 2:16,130,788...16,133,510
G
PTN
pleiotrophin
affects binding
EXP
[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to PTN protein
CTD
PMID:14699094
NCBI chr18:12,219,708...12,309,045
Ensembl chr18:12,219,787...12,309,044
G
CASP1
caspase 1, apoptosis-related cysteine peptidase
multiple interactions increases expression
EXP
[Dextran Sulfate co-treated with Zearalenone] results in increased expression of CASP1 mRNA; [Dextran Sulfate co-treated with Zearalenone] results in increased expression of CASP1 protein; Zearalenone inhibits the reaction [Dextran Sulfate results in increased expression of CASP1 mRNA] Dextran Sulfate results in increased expression of CASP1 mRNA; Dextran Sulfate results in increased expression of CASP1 protein
CTD
PMID:30270565
NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328
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IL18
interleukin 18
increases expression multiple interactions
EXP
Dextran Sulfate results in increased expression of IL18 mRNA [Dextran Sulfate co-treated with Zearalenone] results in increased expression of IL18 mRNA; Dextran Sulfate inhibits the reaction [Zearalenone results in increased expression of IL18 mRNA]; Zearalenone inhibits the reaction [Dextran Sulfate results in increased expression of IL18 mRNA]
CTD
PMID:30270565
NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219
G
LOC110258578
interleukin-1 beta-like
multiple interactions increases expression
EXP
[Dextran Sulfate co-treated with Zearalenone] results in increased expression of IL1B mRNA; Dextran Sulfate inhibits the reaction [Zearalenone results in increased expression of IL1B mRNA]; Zearalenone inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]
CTD
PMID:30270565
G
NLRP3
NLR family pyrin domain containing 3
multiple interactions increases expression
EXP
[Dextran Sulfate co-treated with Zearalenone] results in increased expression of NLRP3 mRNA; [Dextran Sulfate co-treated with Zearalenone] results in increased expression of NLRP3 protein; Dextran Sulfate inhibits the reaction [Zearalenone results in increased expression of NLRP3 mRNA]; Zearalenone inhibits the reaction [Dextran Sulfate results in increased expression of NLRP3 mRNA]; Zearalenone inhibits the reaction [Dextran Sulfate results in increased expression of NLRP3 protein] Dextran Sulfate results in increased expression of NLRP3 mRNA; Dextran Sulfate results in increased expression of NLRP3 protein
CTD
PMID:30270565
NCBI chr 2:56,892,241...56,977,412
Ensembl chr 2:56,892,243...56,977,228
G
PYCARD
PYD and CARD domain containing
multiple interactions increases expression
EXP
[Dextran Sulfate co-treated with Zearalenone] results in increased expression of PYCARD mRNA; [Dextran Sulfate co-treated with Zearalenone] results in increased expression of PYCARD protein Dextran Sulfate results in increased expression of PYCARD mRNA; Dextran Sulfate results in increased expression of PYCARD protein
CTD
PMID:30270565
NCBI chr 3:17,305,921...17,307,521
Ensembl chr 3:17,306,099...17,307,786
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ACHE
acetylcholinesterase
decreases activity
EXP
Diazinon results in decreased activity of ACHE protein
CTD
PMID:21467751
NCBI chr 3:8,732,451...8,738,274
Ensembl chr 3:8,732,441...8,738,605
G
POMC
proopiomelanocortin
multiple interactions
EXP
Ditiocarb promotes the reaction [Sodium Selenite inhibits the reaction [POMC protein results in increased secretion of Hydrocortisone]]
CTD
PMID:21466817
NCBI chr 3:113,661,712...113,668,558
Ensembl chr 3:113,661,004...113,670,418
G
SOD1
superoxide dismutase 1
multiple interactions decreases activity
EXP
SOD1 protein affects the susceptibility to [Ditiocarb co-treated with 6-anilino-5,8-quinolinedione] Ditiocarb results in decreased activity of SOD1 protein
CTD
PMID:11861319
NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729
G
INS
insulin
multiple interactions
EXP
Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS protein results in increased uptake of 2-(methylamino)isobutyric acid]]
CTD
PMID:1928324
NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841
G
CYP2E1
cytochrome P450 family 2 subfamily E member 1
multiple interactions
EXP
Disulfiram inhibits the reaction [4-xylene results in increased activity of CYP2E1 protein]; Disulfiram inhibits the reaction [Toluene results in increased activity of CYP2E1 protein]
CTD
PMID:12781212
NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,817
G
TNF
tumor necrosis factor
multiple interactions
EXP
Disulfiram inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]
CTD
PMID:10975995
NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
G
SLCO1A2
solute carrier organic anion transporter family member 1A2
increases uptake multiple interactions
EXP
SLCO1A2 protein results in increased uptake of estrone sulfate Amoxicillin inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; cefquinome inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Chlortetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Clarithromycin inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; daidzein inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Doxycycline inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Erythromycin inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Genistein inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; naringin inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Oxytetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Penicillins inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Tetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; tilmicosin inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Tylosin inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]
CTD
PMID:31287969
NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,049,443...52,129,730
G
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
affects expression
EXP
Fenbendazole affects the expression of ABCB1 mRNA
CTD
PMID:26366864
NCBI chr 9:93,049,955...93,146,469
G
CYP1A2
cytochrome P450 family 1 subfamily A member 2
affects expression
EXP
Fenbendazole affects the expression of CYP1A2 mRNA
CTD
PMID:26366864
NCBI chr 7:58,779,529...58,786,155
Ensembl chr 7:58,779,475...58,786,100
G
CYP2E1
cytochrome P450 family 2 subfamily E member 1
affects expression
EXP
Fenbendazole affects the expression of CYP2E1 mRNA
CTD
PMID:26366864
NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,817
G
CYP3A22
cytochrome P450 family 3 subfamily A member 22
affects expression
EXP
Fenbendazole affects the expression of CYP3A22 mRNA
CTD
PMID:26366864
NCBI chr 3:6,617,256...6,665,179
Ensembl chr 3:6,615,343...6,822,817
G
CYP3A29
cytochrome P450 family 3 subfamily A member 29
affects expression
EXP
Fenbendazole affects the expression of CYP3A29 mRNA
CTD
PMID:26366864
NCBI chr 3:6,738,502...6,778,121
Ensembl chr 3:6,738,486...6,778,944
G
SULT1A3
sulfotransferase family 1A member 3
affects expression
EXP
Fenbendazole affects the expression of SULT1A1 mRNA
CTD
PMID:26366864
NCBI chr 3:18,351,205...18,354,653
Ensembl chr 3:18,351,194...18,354,649
G
TNF
tumor necrosis factor
multiple interactions
EXP
[laminaran co-treated with fucoidan co-treated with Minerals] promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
CTD
PMID:21948611
NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
G
HOXA10
homeobox A10
decreases expression multiple interactions
EXP
Fulvestrant results in decreased expression of HOXA10 mRNA Fulvestrant inhibits the reaction [Estradiol results in increased expression of HOXA10 mRNA]
CTD
PMID:21705055
NCBI chr18:45,393,525...45,403,259
Ensembl chr18:45,393,885...45,403,257
G
NOS3
nitric oxide synthase 3
multiple interactions
EXP
Fulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of NOS3 protein]; Fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in increased phosphorylation of NOS3 protein]
CTD
PMID:17618301
NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
G
PTGS2
prostaglandin-endoperoxide synthase 2
multiple interactions
EXP
Fulvestrant inhibits the reaction [Estradiol results in increased expression of PTGS2 mRNA]
CTD
PMID:21705055
NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884
G
AOC1
amine oxidase copper containing 1
multiple interactions
EXP
Glutathione inhibits the reaction [Paraquat results in increased expression of AOC1 protein]
CTD
PMID:36615853
NCBI chr18:6,309,583...6,321,016
Ensembl chr18:6,309,594...6,320,974
G
CYP2B6B
cytochrome P450 family 2 subfamily B member 6B
multiple interactions
EXP
[Glutathione co-treated with Paraquat] results in decreased expression of CYP2B6B mRNA
CTD
PMID:36615853
NCBI chr 6:49,158,175...49,173,872
Ensembl chr 6:49,110,812...49,178,334
G
CYP3A39
cytochrome P450 3A39
multiple interactions
EXP
Glutathione inhibits the reaction [Paraquat results in increased expression of CYP3A39 mRNA]
CTD
PMID:36615853
G
DNAJC7
DnaJ heat shock protein family (Hsp40) member C7
multiple interactions
EXP
[Glutathione co-treated with Paraquat] results in increased expression of DNAJC7 mRNA
CTD
PMID:36615853
NCBI chr12:20,725,937...20,756,295
Ensembl chr12:20,725,975...20,759,000
G
FABP2
fatty acid binding protein 2
multiple interactions
EXP
Glutathione inhibits the reaction [Paraquat results in increased activity of FABP2 protein]
CTD
PMID:36615853
NCBI chr 8:104,464,342...104,468,059
Ensembl chr 8:104,464,342...104,470,480
G
GCLM
glutamate-cysteine ligase modifier subunit
multiple interactions
EXP
[Glutathione co-treated with Paraquat] results in increased expression of GCLM mRNA
CTD
PMID:36615853
NCBI chr 4:123,371,198...123,390,130
Ensembl chr 4:123,371,193...123,390,131
G
GPX4
glutathione peroxidase 4
multiple interactions
EXP
[Glutathione co-treated with Paraquat] results in increased expression of GPX4 mRNA
CTD
PMID:36615853
NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,931
G
HSP90AA1
heat shock protein 90 alpha family class A member 1
multiple interactions
EXP
[Glutathione co-treated with Paraquat] results in decreased expression of HSP90AA1 mRNA
CTD
PMID:36615853
G
IDH2
isocitrate dehydrogenase (NADP(+)) 2
multiple interactions
EXP
Glutathione inhibits the reaction [Cadmium Chloride results in decreased activity of IDH2 protein]; Glutathione inhibits the reaction [Cadmium results in decreased activity of IDH2 protein]
CTD
PMID:16785314
NCBI chr 7:55,654,298...55,675,571
Ensembl chr 7:55,651,609...55,675,554
G
IFNG
interferon gamma
multiple interactions
EXP
Glutathione inhibits the reaction [Paraquat results in increased expression of IFNG mRNA]
CTD
PMID:36615853
NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670
G
IL10
interleukin 10
multiple interactions
EXP
[Glutathione co-treated with Paraquat] results in increased expression of IL10 mRNA
CTD
PMID:36615853
NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378
G
LOC100739508
glutathione S-transferase P-like
multiple interactions
EXP
GSTP1 protein affects the metabolism of [monobromobimane co-treated with Glutathione]
CTD
PMID:14573868
NCBI chr 2:5,005,498...5,009,247
G
LOC106504562
glutathione S-transferase alpha M14
multiple interactions
EXP
[Glutathione co-treated with Paraquat] results in increased expression of GSTA2 mRNA; Glutathione inhibits the reaction [Paraquat results in decreased expression of GSTA1 mRNA]
CTD
PMID:36615853
NCBI chr 7:46,553,813...46,567,596
G
NR1I3
nuclear receptor subfamily 1 group I member 3
multiple interactions
EXP
Glutathione inhibits the reaction [Paraquat results in increased expression of NR1I3 mRNA]
CTD
PMID:36615853
NCBI chr 4:89,226,314...89,231,781
Ensembl chr 4:89,226,690...89,236,431
G
OCLN
occludin
multiple interactions
EXP
Glutathione inhibits the reaction [Paraquat results in decreased expression of OCLN protein]
CTD
PMID:36615853
NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033
G
SOD2
superoxide dismutase 2
multiple interactions
EXP
[Glutathione co-treated with Paraquat] affects the expression of SOD2 mRNA
CTD
PMID:36615853
NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560
G
TJP1
tight junction protein 1
multiple interactions
EXP
Glutathione inhibits the reaction [Paraquat results in decreased expression of TJP1 protein]
CTD
PMID:36615853
NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836
G
EDN1
endothelin 1
multiple interactions
EXP
Glyburide inhibits the reaction [Carvedilol results in decreased expression of EDN1 protein]
CTD
PMID:18840580
NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
G
PSP-I
porcine seminal protein I
multiple interactions
EXP
zinc chloride promotes the reaction [PSP-I protein binds to Heparin]; Zinc promotes the reaction [PSP-I protein binds to Heparin]
CTD
PMID:16819821
NCBI chr14:132,302,376...132,309,388
Ensembl chr14:132,302,352...132,308,106
G
ALDH7A1
aldehyde dehydrogenase 7 family member A1
multiple interactions
EXP
Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of ALDH7A1 protein]
CTD
PMID:21296058
NCBI chr 2:129,663,226...129,709,728
Ensembl chr 2:129,662,969...129,709,705
G
HSPA5
heat shock protein family A (Hsp70) member 5
increases expression
EXP
Dithiothreitol metabolite results in increased expression of HSPA5 protein
CTD
PMID:17416481
NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
G
IDH2
isocitrate dehydrogenase (NADP(+)) 2
multiple interactions
EXP
Dithiothreitol inhibits the reaction [Cadmium Chloride results in decreased activity of IDH2 protein]; Dithiothreitol inhibits the reaction [Cadmium results in decreased activity of IDH2 protein]
CTD
PMID:16785314
NCBI chr 7:55,654,298...55,675,571
Ensembl chr 7:55,651,609...55,675,554
G
ALB
albumin
multiple interactions
EXP
Cysteine inhibits the reaction [bisphenol A results in decreased expression of ALB protein]
CTD
PMID:37999554
NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,721,696
G
CLDN1
claudin 1
multiple interactions
EXP
Cysteine inhibits the reaction [bisphenol A results in decreased expression of CLDN1 mRNA]
CTD
PMID:37999554
NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657
G
GCLC
glutamate-cysteine ligase catalytic subunit
multiple interactions
EXP
Cysteine inhibits the reaction [bisphenol A results in increased expression of GCLC mRNA]
CTD
PMID:37999554
NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,565...27,253,530
G
GCLM
glutamate-cysteine ligase modifier subunit
multiple interactions
EXP
Cysteine inhibits the reaction [bisphenol A results in increased expression of GCLM mRNA]
CTD
PMID:37999554
NCBI chr 4:123,371,198...123,390,130
Ensembl chr 4:123,371,193...123,390,131
G
HMOX1
heme oxygenase 1
multiple interactions
EXP
Cysteine inhibits the reaction [bisphenol A results in decreased expression of HMOX1 mRNA]
CTD
PMID:37999554
G
KEAP1
kelch like ECH associated protein 1
multiple interactions
EXP
Cysteine inhibits the reaction [bisphenol A results in increased expression of KEAP1 mRNA]
CTD
PMID:37999554
NCBI chr 2:69,280,940...69,290,267
Ensembl chr 2:69,276,336...69,294,382
G
NOX1
NADPH oxidase 1
multiple interactions
EXP
Cysteine inhibits the reaction [bisphenol A results in decreased expression of NOX1 mRNA]
CTD
PMID:37999554
NCBI chr X:82,540,664...82,575,811
Ensembl chr X:82,540,667...82,586,532
G
PPP1R16A
protein phosphatase 1 regulatory subunit 16A
multiple interactions
EXP
Cysteine inhibits the reaction [bisphenol A results in increased activity of GPT protein]
CTD
PMID:37999554
NCBI chr 4:302,621...320,048
Ensembl chr 4:297,748...320,056
G
SDHA
succinate dehydrogenase complex flavoprotein subunit A
multiple interactions
EXP
Cysteine inhibits the reaction [bisphenol A results in decreased expression of SDHA mRNA]
CTD
PMID:37999554
NCBI chr16:79,838,442...79,862,956
Ensembl chr16:79,834,044...79,862,524
G
SOD2
superoxide dismutase 2
multiple interactions
EXP
Cysteine inhibits the reaction [bisphenol A results in decreased expression of SOD2 mRNA]
CTD
PMID:37999554
NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560
G
TJP2
tight junction protein 2
multiple interactions
EXP
Cysteine inhibits the reaction [bisphenol A results in decreased expression of TJP2 mRNA]
CTD
PMID:37999554
NCBI chr 1:222,474,518...222,612,989
Ensembl chr 1:222,474,639...222,612,983
G
NFE2L2
NFE2 like bZIP transcription factor 2
multiple interactions
EXP
Thioctic Acid inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]
CTD
PMID:24512358
NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183
G
AKT2
AKT serine/threonine kinase 2
increases expression
EXP
Malathion results in increased expression of AKT2 mRNA
CTD
PMID:31535366
NCBI chr 6:48,555,785...48,620,472
Ensembl chr 6:48,555,795...48,587,919
G
BAX
BCL2 associated X, apoptosis regulator
increases expression
EXP
Malathion results in increased expression of BAX mRNA
CTD
PMID:31535366
NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140
G
BCL2
BCL2 apoptosis regulator
decreases expression multiple interactions
EXP
Malathion results in decreased expression of BCL2 mRNA Melatonin inhibits the reaction [Malathion results in decreased expression of BCL2 mRNA]
CTD
PMID:31535366
NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879
G
CAT
catalase
decreases expression multiple interactions
EXP
Malathion results in decreased expression of CAT mRNA Melatonin inhibits the reaction [Malathion results in decreased expression of CAT mRNA]
CTD
PMID:31535366
NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
G
CYP1A1
cytochrome P450 family 1 subfamily A member 1
decreases expression
EXP
Malathion results in decreased expression of CYP1A1 mRNA
CTD
PMID:31535366
NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,802,887...58,809,775
G
CYP1B1
cytochrome P450 family 1 subfamily B member 1
decreases expression
EXP
Malathion results in decreased expression of CYP1B1 mRNA
CTD
PMID:31535366
NCBI chr 3:102,195,743...102,205,687
Ensembl chr 3:102,195,741...102,205,683
G
DUOX2
dual oxidase 2
decreases expression
EXP
Malathion results in decreased expression of DUOX2 mRNA
CTD
PMID:31535366
NCBI chr 1:126,620,468...126,641,406
Ensembl chr 1:126,620,510...126,641,406
G
GPX4
glutathione peroxidase 4
increases expression
EXP
Malathion results in increased expression of GPX4 mRNA
CTD
PMID:31535366
NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,931
G
GPX6
glutathione peroxidase 6
increases expression
EXP
Malathion results in increased expression of GPX6 mRNA
CTD
PMID:31535366
NCBI chr 7:22,256,013...22,267,992
Ensembl chr 7:22,256,038...22,267,992
G
LOC106504562
glutathione S-transferase alpha M14
decreases expression
EXP
Malathion results in decreased expression of GSTA1 mRNA
CTD
PMID:31535366
NCBI chr 7:46,553,813...46,567,596
G
MT-CO1
mitochondrially encoded cytochrome c oxidase I
affects expression
EXP
Malathion affects the expression of COX1 mRNA
CTD
PMID:17454254
NCBI chr MT:6,511...8,055
Ensembl chr MT:6,511...8,055
G
MT-CO3
mitochondrially encoded cytochrome c oxidase III
affects expression
EXP
Malathion affects the expression of COX3 mRNA
CTD
PMID:17454254
NCBI chr MT:9,800...10,583
Ensembl chr MT:9,800...10,583
G
PLIN2
perilipin 2
multiple interactions decreases expression
EXP
Melatonin inhibits the reaction [Malathion results in decreased expression of PLIN2 mRNA]; Melatonin inhibits the reaction [Malathion results in decreased expression of PLIN2 protein] Malathion results in decreased expression of PLIN2 mRNA; Malathion results in decreased expression of PLIN2 protein
CTD
PMID:31535366
NCBI chr 1:203,683,867...203,709,277
Ensembl chr 1:203,683,862...203,709,273
G
PPARG
peroxisome proliferator activated receptor gamma
multiple interactions decreases expression
EXP
Melatonin inhibits the reaction [Malathion results in decreased expression of PPARG mRNA]; Melatonin inhibits the reaction [Malathion results in decreased expression of PPARG protein] Malathion results in decreased expression of PPARG mRNA; Malathion results in decreased expression of PPARG protein
CTD
PMID:31535366
NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944
G
SLC34A2
solute carrier family 34 member 2
increases expression
EXP
Malathion results in increased expression of SLC34A2 mRNA
CTD
PMID:31535366
NCBI chr 8:19,481,127...19,507,903
Ensembl chr 8:19,481,198...19,509,666
G
SOD2
superoxide dismutase 2
increases expression
EXP
Malathion results in increased expression of SOD2 mRNA
CTD
PMID:31535366
NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560
G
SORD
sorbitol dehydrogenase
increases expression
EXP
Malathion results in increased expression of SORD mRNA
CTD
PMID:31535366
NCBI chr 1:126,659,198...126,701,084
Ensembl chr 1:126,655,156...126,701,138
G
TP53
tumor protein p53
increases expression multiple interactions
EXP
Malathion results in increased expression of TP53 mRNA Melatonin inhibits the reaction [Malathion results in increased expression of TP53 mRNA]
CTD
PMID:31535366
NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818
G
ALDH7A1
aldehyde dehydrogenase 7 family member A1
multiple interactions
EXP
Mercaptoethanol inhibits the reaction [Hydrogen Peroxide results in decreased activity of ALDH7A1 protein]
CTD
PMID:21296058
NCBI chr 2:129,663,226...129,709,728
Ensembl chr 2:129,662,969...129,709,705
G
HTR2C
5-hydroxytryptamine receptor 2C
affects binding multiple interactions
EXP
mesulergine binds to HTR2C protein 8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine inhibits the reaction [mesulergine binds to HTR2C protein]
CTD
PMID:11927170
NCBI chr X:94,053,415...94,313,352
Ensembl chr X:94,053,456...94,313,355
G
FMO1
flavin containing dimethylaniline monoxygenase 1
increases metabolic processing
EXP
FMO1 protein results in increased metabolism of Methimazole
CTD
PMID:6439199
NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,868,064...63,895,076
G
TPO
thyroid peroxidase
decreases activity
EXP
Methimazole results in decreased activity of TPO protein
CTD
PMID:23959146
NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,409,208
G
MYL9
myosin light chain 9
decreases phosphorylation
EXP
ML 7 results in decreased phosphorylation of MYL9 protein
CTD
PMID:10942722
NCBI chr17:39,788,165...39,795,240
Ensembl chr17:39,788,199...39,795,293
G
MYLK
myosin light chain kinase
multiple interactions
EXP
[ML 7 results in decreased activity of MYLK protein] which results in decreased uptake of Calcium
CTD
PMID:9506478
NCBI chr13:136,509,878...136,809,674
Ensembl chr13:136,509,755...136,809,668
G
CREB1
cAMP responsive element binding protein 1
multiple interactions
EXP
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Brimonidine Tartrate results in increased phosphorylation of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]
CTD
PMID:17680988
NCBI chr15:110,705,548...110,773,037
Ensembl chr15:110,705,496...110,771,728
G
IL6
interleukin 6
decreases expression multiple interactions
EXP
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased expression of IL6 protein N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of IL6 protein]
CTD
PMID:24105867
NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
G
PRKACA
protein kinase cAMP-activated catalytic subunit alpha
multiple interactions
EXP
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of PRKACG protein]
CTD
PMID:24105867
NCBI chr 2:65,074,876...65,095,564
Ensembl chr 2:65,074,870...65,095,551
G
BAX
BCL2 associated X, apoptosis regulator
multiple interactions
EXP
Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of BAX protein]
CTD
PMID:19135140 PMID:33905761
NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140
G
BCL2
BCL2 apoptosis regulator
multiple interactions
EXP
[Acetylcysteine co-treated with fumonisin B1 co-treated with deoxynivalenol] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with fumonisin B1] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with Zearalenone co-treated with deoxynivalenol] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with Zearalenone] results in increased expression of BCL2 protein; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [Cadmium results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone results in decreased expression of BCL2 mRNA]]
CTD
PMID:19135140 PMID:29109043 PMID:33905761
NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879
G
BMP15
bone morphogenetic protein 15
multiple interactions
EXP
Acetylcysteine inhibits the reaction [Zearalenone results in decreased expression of BMP15 mRNA]
CTD
PMID:26386189
NCBI chr X:44,613,122...44,620,575
Ensembl chr X:44,613,122...44,620,575
G
CASP1
caspase 1, apoptosis-related cysteine peptidase
multiple interactions
EXP
Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of and results in increased cleavage of CASP1 protein]
CTD
PMID:36281498
NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328
G
CASP3
caspase 3
multiple interactions
EXP
[Acetylcysteine co-treated with Zearalenone] results in decreased expression of CASP3 protein; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein modified form]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] promotes the reaction [deoxynivalenol results in increased expression of CASP3 protein]]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [[fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [deoxynivalenol results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [deoxynivalenol results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [deoxynivalenol results in increased expression of CASP3 protein]]
CTD
PMID:17383151 PMID:19135140 PMID:29109043 PMID:33905761
NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
G
CASP9
caspase 9
multiple interactions
EXP
Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein modified form]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased activity of CASP9 protein]
CTD
PMID:19135140 PMID:33905761
NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007
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CAT
catalase
multiple interactions
EXP
Acetylcysteine inhibits the reaction [ochratoxin A results in decreased expression of CAT mRNA]
CTD
PMID:36281498
NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
G
CCL2
chemokine (C-C motif) ligand 2
multiple interactions
EXP
Acetylcysteine inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]
CTD
PMID:19265715
NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026
G
CYCS
cytochrome c, somatic
multiple interactions
EXP
Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [[Zearalenone co-treated with fumonisin B1] results in increased expression of CYCS mRNA]]; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CYCS mRNA]]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CYCS mRNA]]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [[deoxynivalenol co-treated with fumonisin B1] results in increased expression of CYCS mRNA]]
CTD
PMID:29109043
NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
G
DDIT3
DNA damage inducible transcript 3
multiple interactions
EXP
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA]
CTD
PMID:18086661
NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829
G
FOS
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
EXP
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA]
CTD
PMID:18086661
NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
G
GPX1
glutathione peroxidase 1
multiple interactions
EXP
Acetylcysteine inhibits the reaction [ochratoxin A results in decreased expression of GPX1 mRNA]
CTD
PMID:36281498
NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433
G
GPX4
glutathione peroxidase 4
multiple interactions
EXP
Acetylcysteine inhibits the reaction [ochratoxin A results in decreased expression of GPX4 mRNA]
CTD
PMID:36281498
NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,931
G
GSDMD
gasdermin D
multiple interactions
EXP
Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of GSDMD protein]
CTD
PMID:36281498
NCBI chr 4:995,753...1,001,964
Ensembl chr 4:995,763...1,000,271
G
GSR
glutathione-disulfide reductase
multiple interactions
EXP
Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]]
CTD
PMID:29109043
NCBI chr15:54,382,564...54,433,989
Ensembl chr15:54,382,567...54,433,984
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HSP90B1
heat shock protein 90 beta family member 1
multiple interactions
EXP
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HSP90B1 mRNA]
CTD
PMID:18086661
NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991
G
HSPA5
heat shock protein family A (Hsp70) member 5
multiple interactions
EXP
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 mRNA]
CTD
PMID:18086661
NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
G
LOC110258578
interleukin-1 beta-like
multiple interactions
EXP
Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of IL1B protein]
CTD
PMID:36281498
G
MAPK8
mitogen-activated protein kinase 8
multiple interactions
EXP
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]
CTD
PMID:17383151
NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874
G
MAPK9
mitogen-activated protein kinase 9
multiple interactions
EXP
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK9 protein]
CTD
PMID:17383151
NCBI chr 2:78,338,466...78,399,108
Ensembl chr 2:78,338,376...78,399,100
G
MYC
MYC proto-oncogene, bHLH transcription factor
multiple interactions
EXP
Acetylcysteine inhibits the reaction [Cisplatin results in increased expression of MYC]
CTD
PMID:12712633
NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,122...12,461,078
G
NFE2L2
NFE2 like bZIP transcription factor 2
multiple interactions
EXP
Acetylcysteine inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]
CTD
PMID:24512358
NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183
G
NLRP3
NLR family pyrin domain containing 3
multiple interactions
EXP
Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of NLRP3 protein]
CTD
PMID:36281498
NCBI chr 2:56,892,241...56,977,412
Ensembl chr 2:56,892,243...56,977,228
G
NOS2
nitric oxide synthase 2
multiple interactions
EXP
Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of INOS mRNA]
CTD
PMID:36281498
NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146
G
PTGS2
prostaglandin-endoperoxide synthase 2
multiple interactions
EXP
Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of PTGS2 mRNA]
CTD
PMID:36281498
NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884
G
PTX3
pentraxin 3
multiple interactions
EXP
Acetylcysteine inhibits the reaction [Zearalenone results in decreased expression of PTX3 mRNA]
CTD
PMID:26386189
NCBI chr13:97,273,594...97,279,570
Ensembl chr13:97,273,594...97,279,569
G
PYCARD
PYD and CARD domain containing
multiple interactions
EXP
Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of PYCARD protein]
CTD
PMID:36281498
NCBI chr 3:17,305,921...17,307,521
Ensembl chr 3:17,306,099...17,307,786
G
SQSTM1
sequestosome 1
multiple interactions
EXP
Acetylcysteine inhibits the reaction [Glyphosate results in decreased expression of SQSTM1 protein]
CTD
PMID:35388968
NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938
G
TNFAIP6
TNF alpha induced protein 6
multiple interactions
EXP
Acetylcysteine inhibits the reaction [Zearalenone results in decreased expression of TNFAIP6 mRNA]
CTD
PMID:26386189
NCBI chr15:862,013...881,352
Ensembl chr15:862,015...881,461
G
TP53
tumor protein p53
multiple interactions
EXP
Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone results in increased expression of TP53 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [fumonisin B1 results in increased expression of TP53 mRNA]]; Acetylcysteine promotes the reaction [deoxynivalenol inhibits the reaction [Zearalenone results in increased expression of TP53 mRNA]]
CTD
PMID:29109043
NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818
G
ZP3
zona pellucida glycoprotein 3
multiple interactions
EXP
Acetylcysteine inhibits the reaction [Zearalenone results in decreased expression of ZP3 mRNA]
CTD
PMID:26386189
NCBI chr 3:9,934,760...9,944,924
Ensembl chr 3:9,934,761...9,944,941
G
HSPA5
heat shock protein family A (Hsp70) member 5
multiple interactions
EXP
nimesulide inhibits the reaction [Hydrogen Peroxide results in increased expression of HSPA5 protein]
CTD
PMID:20665602
NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
G
ADCYAP1
adenylate cyclase activating polypeptide 1
multiple interactions
EXP
omega-Conotoxin GVIA inhibits the reaction [ADCYAP1 protein alternative form results in decreased susceptibility to 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid]
CTD
PMID:14662737
NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,631...105,422,294
G
OPRM1
opioid receptor mu 1
multiple interactions
EXP
omega-Conotoxin GVIA inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein results in increased transport of Barium]]
CTD
PMID:12031848
NCBI chr 1:12,634,125...12,702,295
Ensembl chr 1:12,528,672...12,702,443
G
VIP
vasoactive intestinal peptide
multiple interactions
EXP
omega-Conotoxin GVIA inhibits the reaction [VIP protein results in decreased susceptibility to 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid]
CTD
PMID:14662737
NCBI chr 1:13,611,786...13,620,250
Ensembl chr 1:13,611,311...13,620,269
G
ABCA1
ATP binding cassette subfamily A member 1
increases expression affects localization
EXP
Pioglitazone results in increased expression of ABCA1 mRNA Pioglitazone affects the localization of ABCA1 protein
CTD
PMID:16530456
NCBI chr 1:246,144,277...246,278,492
Ensembl chr 1:246,144,277...246,278,492
G
APOA1
apolipoprotein A1
multiple interactions increases secretion
EXP
Pioglitazone promotes the reaction [APOA1 protein results in increased transport of Cholesterol] Pioglitazone results in increased secretion of APOA1 protein
CTD
PMID:16530456
NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,392...44,218,713
G
CLDN3
claudin 3
multiple interactions
EXP
Pioglitazone inhibits the reaction [deoxynivalenol results in decreased expression of CLDN3 protein]
CTD
PMID:36596350
NCBI chr 3:11,019,073...11,020,102
Ensembl chr 3:11,019,073...11,020,102
G
CLDN4
claudin 4
multiple interactions
EXP
Pioglitazone inhibits the reaction [deoxynivalenol results in decreased expression of CLDN4 protein]
CTD
PMID:36596350
NCBI chr 3:11,039,711...11,053,930
Ensembl chr 3:11,039,706...11,053,925
G
LIPG
lipase G, endothelial type
decreases expression
EXP
Pioglitazone results in decreased expression of LIPG mRNA; Pioglitazone results in decreased expression of LIPG protein
CTD
PMID:15953354
NCBI chr 1:99,081,940...99,110,671
Ensembl chr 1:99,081,938...99,110,874
G
MAPK1
mitogen-activated protein kinase 1
multiple interactions
EXP
Pioglitazone promotes the reaction [Troglitazone results in increased phosphorylation of MAPK1 protein]
CTD
PMID:17065204
NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513
G
MAPK3
mitogen-activated protein kinase 3
multiple interactions
EXP
Pioglitazone promotes the reaction [Troglitazone results in increased phosphorylation of MAPK3 protein]
CTD
PMID:17065204
NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
G
PPARG
peroxisome proliferator activated receptor gamma
multiple interactions increases activity
EXP
Troglitazone inhibits the reaction [Pioglitazone results in increased activity of PPARG protein]
CTD
PMID:17065204
NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944
G
SCARB1
scavenger receptor class B member 1
increases expression affects localization
EXP
Pioglitazone results in increased expression of SCARB1 mRNA Pioglitazone affects the localization of SCARB1 protein
CTD
PMID:16530456
NCBI chr14:28,301,421...28,393,568
Ensembl chr14:28,301,294...28,393,568
G
CXCL8
C-X-C motif chemokine ligand 8
multiple interactions
EXP
pyrrolidine dithiocarbamic acid inhibits the reaction [Glyphosate results in increased expression of CXCL8 mRNA]
CTD
PMID:35388968
NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
G
IL6
interleukin 6
multiple interactions
EXP
pyrrolidine dithiocarbamic acid inhibits the reaction [Glyphosate results in increased expression of IL6 mRNA]
CTD
PMID:35388968
NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
G
LOC110258578
interleukin-1 beta-like
multiple interactions
EXP
pyrrolidine dithiocarbamic acid inhibits the reaction [Glyphosate results in increased expression of IL1B mRNA]
CTD
PMID:35388968
G
AKT1
AKT serine/threonine kinase 1
decreases phosphorylation
EXP
Raloxifene Hydrochloride results in decreased phosphorylation of AKT1 protein
CTD
PMID:17348974
G
CAV1
caveolin 1
increases expression
EXP
Raloxifene Hydrochloride results in increased expression of CAV1 protein
CTD
PMID:16680078
NCBI chr18:29,648,120...29,682,451
Ensembl chr18:29,649,992...29,682,465
G
EIF4EBP1
eukaryotic translation initiation factor 4E binding protein 1
decreases phosphorylation
EXP
Raloxifene Hydrochloride results in decreased phosphorylation of EIF4EBP1 protein
CTD
PMID:17348974
NCBI chr15:48,423,001...48,443,373
Ensembl chr15:48,422,816...48,443,399
G
ESR1
estrogen receptor 1
decreases expression affects expression affects binding
EXP
Raloxifene Hydrochloride results in decreased expression of ESR1 protein alternative form Raloxifene Hydrochloride affects the expression of ESR1 protein Raloxifene Hydrochloride metabolite binds to ESR1 protein
CTD
PMID:15653758 PMID:16680078 PMID:16790557 PMID:17348974
NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363
G
ESR2
estrogen receptor 2
affects expression
EXP
Raloxifene Hydrochloride affects the expression of ESR2 protein
CTD
PMID:15653758 PMID:16680078
NCBI chr 1:193,823,666...193,907,330
Ensembl chr 1:193,829,560...193,906,565
G
F3
coagulation factor III, tissue factor
affects expression
EXP
Raloxifene Hydrochloride affects the expression of F3 protein
CTD
PMID:15964915
NCBI chr 4:122,827,018...122,837,673
Ensembl chr 4:122,826,644...122,837,666
G
MMP2
matrix metallopeptidase 2
affects secretion
EXP
Raloxifene Hydrochloride affects the secretion of MMP2 protein
CTD
PMID:15653758
NCBI chr 6:30,059,247...30,087,031
Ensembl chr 6:30,058,595...30,086,982
G
NOS3
nitric oxide synthase 3
increases phosphorylation affects expression multiple interactions decreases expression
EXP
Raloxifene Hydrochloride results in increased phosphorylation of NOS3 protein Raloxifene Hydrochloride affects the expression of NOS3 mRNA Fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in increased phosphorylation of NOS3 protein] Raloxifene Hydrochloride results in decreased expression of NOS3 protein
CTD
PMID:15653758 PMID:16680078 PMID:17618301
NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
G
PDGFB
platelet derived growth factor subunit B
multiple interactions
EXP
Raloxifene Hydrochloride affects the secretion of [PDGFB protein binds to PDGFB protein]
CTD
PMID:15653758
Ensembl chr 5:8,986,462...9,007,435
G
SELP
selectin P
affects expression
EXP
Raloxifene Hydrochloride affects the expression of SELP protein
CTD
PMID:15964915
NCBI chr 4:81,376,804...81,401,240
Ensembl chr 4:81,365,740...81,399,955
G
TNFRSF11B
TNF receptor superfamily member 11b
increases expression
EXP
Raloxifene Hydrochloride results in increased expression of TNFRSF11B protein
CTD
PMID:15713688
NCBI chr 4:19,850,212...19,879,132
Ensembl chr 4:19,850,350...19,879,125
G
CS
citrate synthase
decreases activity
EXP
Riluzole analog results in decreased activity of CS protein
CTD
PMID:33359020
NCBI chr 5:21,669,778...21,700,737
Ensembl chr 5:21,666,585...21,700,711
G
MAOA
monoamine oxidase A
decreases activity
EXP
Riluzole analog results in decreased activity of MAOA protein; Riluzole results in decreased activity of MAOA protein
CTD
PMID:33359020
NCBI chr X:38,930,452...39,006,220
G
MAOB
monoamine oxidase B
decreases activity
EXP
Riluzole analog results in decreased activity of MAOB protein
CTD
PMID:33359020
NCBI chr X:39,025,973...39,144,389
Ensembl chr X:39,025,970...39,144,345
G
NOS3
nitric oxide synthase 3
multiple interactions decreases expression
EXP
Masoprocol inhibits the reaction [Ritonavir results in decreased expression of NOS3 mRNA]; Masoprocol inhibits the reaction [Ritonavir results in decreased expression of NOS3 protein]; Ritonavir results in decreased expression of and results in decreased activity of NOS3 protein Ritonavir results in decreased expression of NOS3 mRNA; Ritonavir results in decreased expression of NOS3 protein
CTD
PMID:15681703 PMID:16123675 PMID:22037733
NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
G
COMT
catechol-O-methyltransferase
multiple interactions
EXP
[S-Adenosylmethionine analog co-treated with COMT protein] results in increased methylation of catechol
CTD
PMID:20196537
NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,738...51,403,998
G
COMT
catechol-O-methyltransferase
multiple interactions
EXP
[S-Adenosylmethionine analog co-treated with COMT protein] results in increased methylation of catechol
CTD
PMID:20196537
NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,738...51,403,998
G
GCLC
glutamate-cysteine ligase catalytic subunit
multiple interactions decreases activity
EXP
Buthionine Sulfoximine inhibits the reaction [sulforaphane inhibits the reaction [Cisplatin results in decreased activity of GCLC protein]] Buthionine Sulfoximine results in decreased activity of GCLC protein
CTD
PMID:20732396
NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,565...27,253,530
G
AKT1
AKT serine/threonine kinase 1
multiple interactions
EXP
AKT1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]
CTD
PMID:11514583
G
HIF1A
hypoxia inducible factor 1 subunit alpha
multiple interactions increases expression
EXP
2,3-dimethoxy-1,4-naphthoquinone inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; AKT1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; Genistein inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; PIK3R1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; Wortmannin inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]
CTD
PMID:11514583
NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845
G
PIK3R1
phosphoinositide-3-kinase regulatory subunit 1
multiple interactions
EXP
PIK3R1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]
CTD
PMID:11514583
NCBI chr16:46,434,757...46,523,626
Ensembl chr16:46,511,521...46,523,609
G
EIF2A
eukaryotic translation initiation factor 2A
increases phosphorylation
EXP
salubrinal results in increased phosphorylation of EIF2A protein
CTD
PMID:17464326
NCBI chr13:90,761,453...90,804,274
Ensembl chr13:90,761,465...90,804,274
G
AKT1
AKT serine/threonine kinase 1
multiple interactions
EXP
SB 203580 affects the reaction [etoxazole affects the phosphorylation of AKT1 protein]
CTD
PMID:31744678
G
CCL2
chemokine (C-C motif) ligand 2
multiple interactions
EXP
SB 203580 inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]; SB 203580 inhibits the reaction [titanium dioxide results in increased expression of CCL2 mRNA]
CTD
PMID:19265715 PMID:23380242
NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026
G
CLDN1
claudin 1
multiple interactions
EXP
[SB 203580 co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in decreased expression of CLDN1 mRNA]; SB 203580 inhibits the reaction [Lipopolysaccharides results in decreased expression of CLDN1 mRNA]
CTD
PMID:37271275
NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657
G
LOC110258578
interleukin-1 beta-like
multiple interactions
EXP
[SB 203580 co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
CTD
PMID:37271275
G
MAPK1
mitogen-activated protein kinase 1
multiple interactions
EXP
SB 203580 inhibits the reaction [etoxazole results in increased phosphorylation of MAPK1 protein]
CTD
PMID:31744678
NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513
G
MAPK14
mitogen-activated protein kinase 14
multiple interactions
EXP
[SB 203580 co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK14 mRNA]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK14 mRNA]
CTD
PMID:37271275
NCBI chr 7:31,791,398...31,861,544
Ensembl chr 7:31,790,877...31,862,031
G
MAPK3
mitogen-activated protein kinase 3
multiple interactions
EXP
SB 203580 inhibits the reaction [etoxazole results in increased phosphorylation of MAPK3 protein]
CTD
PMID:31744678
NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
G
MAPK8
mitogen-activated protein kinase 8
multiple interactions
EXP
[SB 203580 co-treated with etoxazole] results in increased phosphorylation of MAPK8 protein
CTD
PMID:31744678
NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874
G
NLRP3
NLR family pyrin domain containing 3
multiple interactions
EXP
[SB 203580 co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 mRNA]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 mRNA]
CTD
PMID:37271275
NCBI chr 2:56,892,241...56,977,412
Ensembl chr 2:56,892,243...56,977,228
G
OCLN
occludin
multiple interactions
EXP
[SB 203580 co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in decreased expression of OCLN mRNA]; SB 203580 inhibits the reaction [Lipopolysaccharides results in decreased expression of OCLN mRNA]
CTD
PMID:37271275
NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033
G
RPS6
ribosomal protein S6
multiple interactions
EXP
SB 203580 affects the reaction [etoxazole affects the phosphorylation of RPS6 protein]
CTD
PMID:31744678
NCBI chr 1:203,444,360...203,447,643
Ensembl chr 1:203,444,450...203,451,468
G
RPS6KB1
ribosomal protein S6 kinase B1
multiple interactions
EXP
SB 203580 affects the reaction [etoxazole affects the phosphorylation of RPS6KB1 protein]
CTD
PMID:31744678
NCBI chr12:36,111,584...36,159,287
Ensembl chr12:36,111,653...36,160,376
G
STAT1
signal transducer and activator of transcription 1
multiple interactions
EXP
SB 203580 inhibits the reaction [Cadmium results in increased phosphorylation of STAT1 protein]
CTD
PMID:21783819
NCBI chr15:95,593,201...95,646,324
Ensembl chr15:95,593,211...95,646,260
G
STAT3
signal transducer and activator of transcription 3
multiple interactions
EXP
SB 203580 inhibits the reaction [Cadmium results in increased phosphorylation of STAT3 protein]
CTD
PMID:21783819
NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,992
G
VCAM1
vascular cell adhesion molecule 1
multiple interactions
EXP
SB 203580 inhibits the reaction [titanium dioxide results in increased expression of VCAM1 mRNA]
CTD
PMID:23380242
NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,920...117,511,222
G
CXCL8
C-X-C motif chemokine ligand 8
multiple interactions
EXP
sodium metabisulfite inhibits the reaction [deoxynivalenol results in increased expression of CXCL8 mRNA]
CTD
PMID:33817499
NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
G
IL6
interleukin 6
multiple interactions
EXP
sodium metabisulfite inhibits the reaction [deoxynivalenol results in increased expression of IL6 mRNA]
CTD
PMID:33817499
NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
G
CALR
calreticulin
increases expression
EXP
sulfamethoxazole hydroxylamine results in increased expression of CALR protein
CTD
PMID:16005169
NCBI chr 2:66,098,263...66,102,074
Ensembl chr 2:66,098,229...66,102,132
G
HSP90B1
heat shock protein 90 beta family member 1
decreases expression
EXP
sulfamethoxazole hydroxylamine results in decreased expression of HSP90B1 protein
CTD
PMID:16005169
NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991
G
HSPA5
heat shock protein family A (Hsp70) member 5
increases expression
EXP
sulfamethoxazole hydroxylamine results in increased expression of HSPA5 protein
CTD
PMID:16005169
NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
G
CCL2
chemokine (C-C motif) ligand 2
multiple interactions
EXP
sulforaphane inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]
CTD
PMID:21130106
NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026
G
FIS1
fission, mitochondrial 1
decreases expression
EXP
sulforaphane results in decreased expression of FIS1 protein
CTD
PMID:27993529
NCBI chr 3:8,938,250...8,942,102
Ensembl chr 3:8,937,453...8,946,955
G
GCLC
glutamate-cysteine ligase catalytic subunit
increases expression increases activity multiple interactions
EXP
sulforaphane results in increased expression of GCLC mRNA sulforaphane results in increased activity of GCLC protein Buthionine Sulfoximine inhibits the reaction [sulforaphane inhibits the reaction [Cisplatin results in decreased activity of GCLC protein]]; ochratoxin A inhibits the reaction [sulforaphane results in increased expression of GCLC mRNA]; sulforaphane inhibits the reaction [Cisplatin results in decreased activity of GCLC protein]
CTD
PMID:18547363 PMID:20732396
NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,565...27,253,530
G
HMOX1
heme oxygenase 1
multiple interactions increases expression
EXP
NFE2L2 protein affects the reaction [sulforaphane results in increased expression of HMOX1 protein]
CTD
PMID:28710020
G
LOC106504562
glutathione S-transferase alpha M14
increases expression multiple interactions
EXP
sulforaphane results in increased expression of GSTA1 mRNA ochratoxin A inhibits the reaction [sulforaphane results in increased expression of GSTA1 mRNA]
CTD
PMID:18547363
NCBI chr 7:46,553,813...46,567,596
G
MT-ND1
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1
increases expression
EXP
sulforaphane results in increased expression of ND1 protein
CTD
PMID:27993529
NCBI chr MT:3,922...4,876
Ensembl chr MT:3,922...4,876
G
NFE2L2
NFE2 like bZIP transcription factor 2
multiple interactions increases activity affects localization increases expression
EXP
NFE2L2 protein affects the reaction [sulforaphane results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [sulforaphane results in increased expression of NQO1 protein]; ochratoxin A inhibits the reaction [sulforaphane affects the localization of NFE2L2 protein]; ochratoxin A inhibits the reaction [sulforaphane results in increased activity of NFE2L2 protein]; ochratoxin A inhibits the reaction [sulforaphane results in increased expression of NFE2L2 mRNA]; sulforaphane results in increased expression of and results in increased activity of NFE2L2 protein
CTD
PMID:18547363 PMID:19913604 PMID:21130106 PMID:28710020
NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183
G
NQO1
NAD(P)H quinone dehydrogenase 1
multiple interactions increases expression increases activity
EXP
Dicumarol inhibits the reaction [sulforaphane inhibits the reaction [Cisplatin results in decreased activity of NQO1 protein]]; NFE2L2 protein affects the reaction [sulforaphane results in increased expression of NQO1 protein]; sulforaphane inhibits the reaction [Cisplatin results in decreased activity of NQO1 protein] sulforaphane results in increased activity of NQO1 protein
CTD
PMID:20732396 PMID:28710020
NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,770...17,302,590
G
NRF1
nuclear respiratory factor 1
increases expression
EXP
sulforaphane results in increased expression of NRF1 protein
CTD
PMID:27993529
NCBI chr18:19,008,408...19,142,678
Ensembl chr18:18,998,930...19,142,628
G
TFAM
transcription factor A, mitochondrial
increases expression
EXP
sulforaphane results in increased expression of TFAM protein
CTD
PMID:27993529
NCBI chr14:92,261,713...92,279,731
Ensembl chr14:92,259,403...92,279,731
G
TGFB1
transforming growth factor beta 1
multiple interactions
EXP
sulforaphane inhibits the reaction [ochratoxin A results in increased expression of TGFB1 mRNA]
CTD
PMID:28710020
NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,173...49,349,046
G
PLA2G1B
phospholipase A2 group IB
multiple interactions
EXP
Sulindac promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA]
CTD
PMID:10706128
NCBI chr14:40,314,520...40,322,315
Ensembl chr14:40,314,520...40,322,315
G
PTGS2
prostaglandin-endoperoxide synthase 2
multiple interactions
EXP
Sulindac promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA]
CTD
PMID:10706128
NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884
G
CASP1
caspase 1, apoptosis-related cysteine peptidase
multiple interactions
EXP
Taurine inhibits the reaction [ochratoxin A results in increased expression of and results in increased cleavage of CASP1 protein]
CTD
PMID:36281498
NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328
G
CAT
catalase
multiple interactions
EXP
Taurine inhibits the reaction [ochratoxin A results in decreased expression of CAT mRNA]
CTD
PMID:36281498
NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
G
GPX1
glutathione peroxidase 1
multiple interactions
EXP
Taurine inhibits the reaction [ochratoxin A results in decreased expression of GPX1 mRNA]
CTD
PMID:36281498
NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433
G
GPX4
glutathione peroxidase 4
multiple interactions
EXP
Taurine inhibits the reaction [ochratoxin A results in decreased expression of GPX4 mRNA]
CTD
PMID:36281498
NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,931
G
GSDMD
gasdermin D
multiple interactions
EXP
Taurine inhibits the reaction [ochratoxin A results in increased expression of GSDMD protein]
CTD
PMID:36281498
NCBI chr 4:995,753...1,001,964
Ensembl chr 4:995,763...1,000,271
G
LOC110258578
interleukin-1 beta-like
multiple interactions
EXP
Taurine inhibits the reaction [ochratoxin A results in increased expression of IL1B protein]
CTD
PMID:36281498
G
NLRP3
NLR family pyrin domain containing 3
multiple interactions
EXP
Taurine inhibits the reaction [ochratoxin A results in increased expression of NLRP3 protein]
CTD
PMID:36281498
NCBI chr 2:56,892,241...56,977,412
Ensembl chr 2:56,892,243...56,977,228
G
NOS2
nitric oxide synthase 2
multiple interactions
EXP
Taurine inhibits the reaction [ochratoxin A results in decreased expression of INOS mRNA]
CTD
PMID:36281498
NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146
G
PTGS2
prostaglandin-endoperoxide synthase 2
multiple interactions
EXP
Taurine inhibits the reaction [ochratoxin A results in decreased expression of PTGS2 mRNA]
CTD
PMID:36281498
NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884
G
PYCARD
PYD and CARD domain containing
multiple interactions
EXP
Taurine inhibits the reaction [ochratoxin A results in increased expression of PYCARD protein]
CTD
PMID:36281498
NCBI chr 3:17,305,921...17,307,521
Ensembl chr 3:17,306,099...17,307,786
G
ABCB11
ATP binding cassette subfamily B member 11
increases transport
EXP
ABCB11 protein results in increased transport of Taurocholic Acid
CTD
PMID:21056966
NCBI chr15:75,402,296...75,487,092
Ensembl chr15:75,402,396...75,486,403
G
SLCO1A2
solute carrier organic anion transporter family member 1A2
increases uptake multiple interactions
EXP
SLCO1A2 protein results in increased uptake of Taurocholic Acid Amoxicillin inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; cefquinome inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; Clarithromycin inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; daidzein inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; Doxycycline inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; Erythromycin inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; Genistein inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; naringin inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; Oxytetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; Penicillins inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; Tetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; tilmicosin inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; Tylosin inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]
CTD
PMID:31287969
NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,049,443...52,129,730
G
ATF4
activating transcription factor 4
multiple interactions
EXP
ursodoxicoltaurine inhibits the reaction [Cadmium results in increased expression of ATF4 mRNA]
CTD
PMID:37207789
NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368
G
ATF6
activating transcription factor 6
multiple interactions
EXP
ursodoxicoltaurine inhibits the reaction [Cadmium results in increased expression of ATF6 mRNA]
CTD
PMID:37207789
NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304
G
CAT
catalase
multiple interactions
EXP
ursodoxicoltaurine inhibits the reaction [Cadmium results in increased expression of CAT mRNA]
CTD
PMID:37207789
NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
G
DDIT3
DNA damage inducible transcript 3
multiple interactions
EXP
ursodoxicoltaurine inhibits the reaction [Cadmium results in increased expression of DDIT3 mRNA]
CTD
PMID:37207789
NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829
G
HSPA5
heat shock protein family A (Hsp70) member 5
multiple interactions
EXP
ursodoxicoltaurine inhibits the reaction [Cadmium results in increased expression of HSPA5 mRNA]
CTD
PMID:37207789
NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
G
PTGS1
prostaglandin-endoperoxide synthase 1
multiple interactions
EXP
ursodoxicoltaurine inhibits the reaction [Cadmium results in decreased expression of PTGS1 mRNA]
CTD
PMID:37207789
NCBI chr 1:262,456,106...262,482,159
Ensembl chr 1:262,456,155...262,483,035
G
PTGS2
prostaglandin-endoperoxide synthase 2
multiple interactions
EXP
ursodoxicoltaurine inhibits the reaction [Cadmium results in decreased expression of PTGS2 mRNA]
CTD
PMID:37207789
NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884
G
PTX3
pentraxin 3
multiple interactions
EXP
ursodoxicoltaurine inhibits the reaction [Cadmium results in decreased expression of PTX3 mRNA]
CTD
PMID:37207789
NCBI chr13:97,273,594...97,279,570
Ensembl chr13:97,273,594...97,279,569
G
SOD1
superoxide dismutase 1
multiple interactions
EXP
ursodoxicoltaurine inhibits the reaction [Cadmium results in increased expression of SOD1 mRNA]
CTD
PMID:37207789
NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729
G
SOD2
superoxide dismutase 2
multiple interactions
EXP
ursodoxicoltaurine affects the reaction [Cadmium results in increased expression of SOD2 mRNA]
CTD
PMID:37207789
NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560
G
TNFAIP6
TNF alpha induced protein 6
multiple interactions
EXP
[ursodoxicoltaurine co-treated with Cadmium] results in increased expression of TNFAIP6 mRNA; ursodoxicoltaurine inhibits the reaction [Cadmium results in decreased expression of TNFAIP6 mRNA]
CTD
PMID:37207789
NCBI chr15:862,013...881,352
Ensembl chr15:862,015...881,461
G
XBP1
X-box binding protein 1
multiple interactions
EXP
ursodoxicoltaurine inhibits the reaction [Cadmium results in increased splicing of XBP1 mRNA]
CTD
PMID:37207789
NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,016,526
G
RYR1
ryanodine receptor 1
increases activity
EXP
Thymol results in increased activity of RYR1 protein
CTD
PMID:17641978
NCBI chr 6:47,339,759...47,458,457
Ensembl chr 6:47,343,768...47,458,458
G
ABCA1
ATP binding cassette subfamily A member 1
decreases expression affects localization
EXP
Troglitazone results in decreased expression of ABCA1 mRNA Troglitazone affects the localization of ABCA1 protein
CTD
PMID:16530456
NCBI chr 1:246,144,277...246,278,492
Ensembl chr 1:246,144,277...246,278,492
G
APOA1
apolipoprotein A1
increases secretion multiple interactions decreases expression
EXP
Troglitazone results in increased secretion of APOA1 protein Troglitazone promotes the reaction [APOA1 protein results in increased transport of Cholesterol] Troglitazone results in decreased expression of APOA1 mRNA
CTD
PMID:16530456
NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,392...44,218,713
G
CASP3
caspase 3
multiple interactions
EXP
[Troglitazone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of CASP3 mRNA
CTD
PMID:30481989
NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
G
CD36
CD36 molecule
multiple interactions increases expression
EXP
T 0070907 inhibits the reaction [Troglitazone inhibits the reaction [deoxynivalenol results in decreased expression of CD36 mRNA]]; Troglitazone inhibits the reaction [deoxynivalenol results in decreased expression of CD36 mRNA] Troglitazone results in increased expression of CD36 mRNA
CTD
PMID:36596350
NCBI chr 9:99,685,748...99,782,296
Ensembl chr 9:99,605,181...99,782,105
G
CEBPA
CCAAT enhancer binding protein alpha
increases expression multiple interactions
EXP
Troglitazone results in increased expression of CEBPA mRNA Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of CEBPA mRNA]
CTD
PMID:11225715 PMID:30481989
NCBI chr 6:43,083,200...43,085,884
Ensembl chr 6:43,083,207...43,085,836
G
CLDN1
claudin 1
decreases expression
EXP
Troglitazone results in decreased expression of CLDN1 mRNA; Troglitazone results in decreased expression of CLDN1 protein
CTD
PMID:36596350
NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657
G
CLDN3
claudin 3
multiple interactions increases expression
EXP
PPARG protein affects the reaction [Troglitazone inhibits the reaction [deoxynivalenol results in decreased expression of CLDN3 protein]]; T 0070907 inhibits the reaction [Troglitazone inhibits the reaction [deoxynivalenol results in decreased expression of CLDN3 protein]]; Troglitazone inhibits the reaction [deoxynivalenol results in decreased expression of CLDN3 protein] Troglitazone results in increased expression of CLDN3 protein
CTD
PMID:36596350
NCBI chr 3:11,019,073...11,020,102
Ensembl chr 3:11,019,073...11,020,102
G
CLDN4
claudin 4
increases expression multiple interactions
EXP
Troglitazone results in increased expression of CLDN4 mRNA; Troglitazone results in increased expression of CLDN4 protein PPARG protein affects the reaction [Troglitazone inhibits the reaction [deoxynivalenol results in decreased expression of CLDN4 protein]]; T 0070907 inhibits the reaction [Troglitazone inhibits the reaction [deoxynivalenol results in decreased expression of CLDN4 protein]]; Troglitazone inhibits the reaction [deoxynivalenol results in decreased expression of CLDN4 protein]
CTD
PMID:36596350
NCBI chr 3:11,039,711...11,053,930
Ensembl chr 3:11,039,706...11,053,925
G
CTNNB1
catenin beta 1
multiple interactions
EXP
Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of CTNNB1 mRNA]
CTD
PMID:30481989
NCBI chr13:25,163,550...25,208,314
Ensembl chr13:25,164,277...25,208,311
G
CYP17A1
cytochrome P450 family 17 subfamily A member 1
multiple interactions
EXP
Troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased expression of CYP17A1 mRNA]; Troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased expression of CYP17A1 protein modified form]
CTD
PMID:11889176
NCBI chr14:113,805,616...113,820,445
Ensembl chr14:113,805,611...113,812,041
G
FABP4
fatty acid binding protein 4
multiple interactions
EXP
Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of FABP4 mRNA]
CTD
PMID:30481989
NCBI chr 4:55,096,400...55,101,209
Ensembl chr 4:55,096,404...55,101,896
G
IGF1
insulin like growth factor 1
multiple interactions
EXP
Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of IGF1 mRNA]
CTD
PMID:30481989
NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,033
G
IGF1R
insulin like growth factor 1 receptor
multiple interactions
EXP
Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of IGF1R mRNA]
CTD
PMID:30481989
NCBI chr 1:137,383,623...137,691,038
Ensembl chr 1:137,387,825...137,691,058
G
INS
insulin
multiple interactions
EXP
Troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased abundance of Androstenedione]; Troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased abundance of Testosterone]; Troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased expression of CYP17A1 mRNA]; Troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased expression of CYP17A1 protein modified form]
CTD
PMID:11889176
NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841
G
LHB
luteinizing hormone subunit beta
multiple interactions
EXP
Troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased abundance of Androstenedione]; Troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased abundance of Testosterone]; Troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased expression of CYP17A1 mRNA]; Troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased expression of CYP17A1 protein modified form]
CTD
PMID:11889176
NCBI chr 6:54,263,574...54,269,286
Ensembl chr 6:54,263,576...54,271,086
G
MAPK1
mitogen-activated protein kinase 1
increases phosphorylation multiple interactions
EXP
Troglitazone results in increased phosphorylation of MAPK1 protein Pioglitazone promotes the reaction [Troglitazone results in increased phosphorylation of MAPK1 protein]
CTD
PMID:17065204
NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513
G
MAPK3
mitogen-activated protein kinase 3
multiple interactions increases phosphorylation
EXP
Pioglitazone promotes the reaction [Troglitazone results in increased phosphorylation of MAPK3 protein]
CTD
PMID:17065204
NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
G
OCLN
occludin
increases expression
EXP
Troglitazone results in increased expression of OCLN mRNA
CTD
PMID:36596350
NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033
G
PPARG
peroxisome proliferator activated receptor gamma
multiple interactions increases activity decreases expression
EXP
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Troglitazone results in increased activity of PPARG protein]; [Troglitazone co-treated with deoxynivalenol] results in decreased expression of PPARG protein; PPARG protein affects the reaction [Troglitazone inhibits the reaction [deoxynivalenol results in decreased expression of CLDN3 protein]]; PPARG protein affects the reaction [Troglitazone inhibits the reaction [deoxynivalenol results in decreased expression of CLDN4 protein]]; T 0070907 inhibits the reaction [[Troglitazone co-treated with deoxynivalenol] results in decreased expression of PPARG protein]; Troglitazone inhibits the reaction [Pioglitazone results in increased activity of PPARG protein]; Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of PPARG mRNA] Troglitazone results in decreased expression of PPARG mRNA; Troglitazone results in decreased expression of PPARG protein
CTD
PMID:14506076 PMID:17065204 PMID:30481989 PMID:36596350
NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944
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SCARB1
scavenger receptor class B member 1
affects localization
EXP
Troglitazone affects the localization of SCARB1 protein
CTD
PMID:16530456
NCBI chr14:28,301,421...28,393,568
Ensembl chr14:28,301,294...28,393,568
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SPP1
secreted phosphoprotein 1
multiple interactions
EXP
Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of SPP1 mRNA]
CTD
PMID:30481989
NCBI chr 8:131,077,786...131,085,334
Ensembl chr 8:131,077,786...131,085,340
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TNF
tumor necrosis factor
multiple interactions
EXP
[Troglitazone co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]
CTD
PMID:15226458
NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
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ACHE
acetylcholinesterase
multiple interactions decreases activity
EXP
N,N'-monomethylenebis(pyridiniumaldoxime) inhibits the reaction [VX results in decreased activity of ACHE protein]
CTD
PMID:20888357
NCBI chr 3:8,732,451...8,738,274
Ensembl chr 3:8,732,441...8,738,605
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ALOX5
arachidonate 5-lipoxygenase
decreases activity
EXP
zileuton results in decreased activity of ALOX5 protein
CTD
PMID:11509739
NCBI chr14:90,859,209...90,907,084
Ensembl chr14:90,859,016...90,907,094
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BAX
BCL2 associated X, apoptosis regulator
increases expression multiple interactions
EXP
Zinc Sulfate results in increased expression of BAX mRNA 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of BAX mRNA]
CTD
PMID:28803810
NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140
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BECN1
beclin 1
increases expression multiple interactions
EXP
Zinc Sulfate results in increased expression of BECN1 protein 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of BECN1 protein]
CTD
PMID:28803810
NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373
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CASP3
caspase 3
multiple interactions increases expression increases cleavage
EXP
3-methyladenine inhibits the reaction [Zinc Sulfate results in increased cleavage of CASP3 protein] Zinc Sulfate results in increased expression of CASP3 mRNA
CTD
PMID:28803810
NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
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CASP6
caspase 6
increases expression
EXP
Zinc Sulfate results in increased expression of CASP6 mRNA
CTD
PMID:28803810
NCBI chr 8:112,519,450...112,534,315
Ensembl chr 8:112,520,629...112,537,045
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CASP8
caspase 8
multiple interactions increases cleavage
EXP
3-methyladenine inhibits the reaction [Zinc Sulfate results in increased cleavage of CASP8 protein]
CTD
PMID:28803810
NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468
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CYCS
cytochrome c, somatic
increases expression multiple interactions
EXP
Zinc Sulfate results in increased expression of CYCS mRNA 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of CYCS mRNA]
CTD
PMID:28803810
NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
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GPX1
glutathione peroxidase 1
multiple interactions
EXP
Zinc Sulfate inhibits the reaction [Diquat results in decreased expression of GPX1 mRNA]
CTD
PMID:32280687
NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433
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LOC110258578
interleukin-1 beta-like
multiple interactions
EXP
Zinc Sulfate inhibits the reaction [Diquat results in increased expression of IL1B mRNA]
CTD
PMID:32280687
G
MAP1LC3A
microtubule associated protein 1 light chain 3 alpha
increases expression
EXP
Zinc Sulfate results in increased expression of MAP1LC3A mRNA
CTD
PMID:28803810
NCBI chr17:37,957,830...37,959,505
Ensembl chr17:37,957,507...37,959,505
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MT1A
metallothionein 1A
increases expression
EXP
Zinc Sulfate results in increased expression of MT1A mRNA
CTD
PMID:25895165
NCBI chr 6:18,672,016...18,673,673
Ensembl chr 6:18,672,001...18,673,672
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NFE2L2
NFE2 like bZIP transcription factor 2
multiple interactions
EXP
Zinc Sulfate inhibits the reaction [Diquat results in decreased expression of NFE2L2 mRNA]
CTD
PMID:32280687
NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183
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SLC30A1
solute carrier family 30 member 1
increases expression
EXP
Zinc Sulfate results in increased expression of SLC30A1 mRNA
CTD
PMID:25895165
NCBI chr 9:131,633,586...131,636,934
Ensembl chr 9:131,633,585...131,640,672
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SLC39A10
solute carrier family 39 member 10
decreases expression increases expression
EXP
Zinc Sulfate results in decreased expression of SLC39A10 mRNA Zinc Sulfate results in increased expression of SLC39A10 mRNA
CTD
PMID:16804107
NCBI chr15:99,584,830...99,724,621
Ensembl chr15:99,584,872...99,724,611
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SOD1
superoxide dismutase 1
multiple interactions
EXP
Zinc Sulfate inhibits the reaction [Diquat results in decreased expression of SOD1 mRNA]
CTD
PMID:32280687
NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729
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SQSTM1
sequestosome 1
increases expression multiple interactions decreases expression
EXP
Zinc Sulfate results in increased expression of SQSTM1 mRNA 3-methyladenine inhibits the reaction [Zinc Sulfate results in decreased expression of SQSTM1 protein]
CTD
PMID:28803810
NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938
G
TNF
tumor necrosis factor
multiple interactions
EXP
Zinc Sulfate inhibits the reaction [Diquat results in increased expression of TNF mRNA]
CTD
PMID:32280687
NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
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