Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sulfur atom
go back to main search page
Accession:CHEBI:26833 term browser browse the term
Definition:A chalcogen that has formula S.
Synonyms:related_synonym: 16S;   Elemental sulfur;   Formula=S;   InChI=1S/S;   InChIKey=NINIDFKCEFEMDL-UHFFFAOYSA-N;   S;   SMILES=[S];   Schwefel;   azufre;   soufre;   sulfur;   sulphur;   theion
 xref: CAS:7704-34-9;   KEGG:C00087;   KEGG:D06527
 xref_mesh: MESH:D013455
 xref: PPDB:605;   WebElements:S


show annotations for term's descendants           Sort by:
 
(R)-lipoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions EXP Thioctic Acid inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein] CTD PMID:24512358 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
1,3-benzothiazole-2-thiol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TPO thyroid peroxidase decreases activity EXP captax results in decreased activity of TPO protein CTD PMID:23959146, PMID:25953703 NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,408,943
JBrowse link
1,3-thiazolidine-2,4-dione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL6 interleukin 6 multiple interactions EXP 2,4-thiazolidinedione inhibits the reaction [Linoleic Acid results in increased expression of IL6 protein]; [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]] CTD PMID:14519784, PMID:15226458 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions EXP 2,4-thiazolidinedione binds to and results in increased activity of PPARG protein CTD PMID:14519784 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,655...68,433,947
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP 2,4-thiazolidinedione inhibits the reaction [Linoleic Acid results in increased activity of RELA protein] CTD PMID:14519784 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,471
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP [2,4-thiazolidinedione co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]]; [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA]] CTD PMID:15226458 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions EXP [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA]] CTD PMID:15226458 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,908...117,511,226
JBrowse link
1,4-dithiothreitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH7A1 aldehyde dehydrogenase 7 family member A1 multiple interactions EXP Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of ALDH7A1 protein] CTD PMID:21296058 NCBI chr 2:129,663,226...129,709,728
Ensembl chr 2:129,662,296...129,713,729
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Dithiothreitol metabolite results in increased expression of HSPA5 protein CTD PMID:17416481 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions EXP Dithiothreitol inhibits the reaction [Cadmium Chloride results in decreased activity of IDH2 protein]; Dithiothreitol inhibits the reaction [Cadmium results in decreased activity of IDH2 protein] CTD PMID:16785314 NCBI chr 7:55,654,298...55,675,571
Ensembl chr 7:55,651,606...55,681,426
JBrowse link
1-(5-isoquinolinesulfonyl)-2-methylpiperazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA] CTD PMID:7564105 NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
JBrowse link
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5AP arachidonate 5-lipoxygenase activating protein multiple interactions EXP MK-886 inhibits the reaction [aristolochic acid I results in increased expression of ALOX5AP protein] CTD PMID:21658425 NCBI chr11:7,371,328...7,438,111
Ensembl chr11:7,411,644...7,438,108
JBrowse link
G CASP3 caspase 3 multiple interactions EXP MK-886 inhibits the reaction [aristolochic acid I results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:21658425 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC4A2 solute carrier family 4 member 2 multiple interactions EXP 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid promotes the reaction [SLC4A2 protein binds to SLC4A2 protein] CTD PMID:10387099 NCBI chr18:6,149,459...6,166,622
Ensembl chr18:6,149,458...6,165,212
JBrowse link
4,4'-sulfonyldiphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP19A2 cytochrome P450 19A2 decreases expression
affects expression
EXP bis(4-hydroxyphenyl)sulfone results in decreased expression of CYP19A1 mRNA
bis(4-hydroxyphenyl)sulfone affects the expression of CYP19A1 protein
CTD PMID:28352085 NCBI chr 1:120,652,172...120,695,899
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
G ESR1 estrogen receptor 1 decreases expression
increases expression
EXP bis(4-hydroxyphenyl)sulfone results in decreased expression of ESR1 mRNA
bis(4-hydroxyphenyl)sulfone results in increased expression of ESR1 protein
CTD PMID:28352085 NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363
JBrowse link
G ESR2 estrogen receptor 2 increases expression
decreases expression
EXP bis(4-hydroxyphenyl)sulfone results in increased expression of ESR2 protein
bis(4-hydroxyphenyl)sulfone results in decreased expression of ESR2 mRNA
CTD PMID:28352085 NCBI chr 1:193,823,666...193,907,330
Ensembl chr 1:193,722,164...193,906,565
JBrowse link
5-(2-methylpiperazine-1-sulfonyl)isoquinoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA] CTD PMID:7564105 NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
JBrowse link
6-propyl-2-thiouracil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TPO thyroid peroxidase decreases activity EXP Propylthiouracil results in decreased activity of TPO protein CTD PMID:23959146 NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,408,943
JBrowse link
amoxicillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1A2 solute carrier organic anion transporter family member 1A2 multiple interactions
increases uptake
EXP Amoxicillin inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Amoxicillin inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]
SLCO1A2 protein results in increased uptake of Amoxicillin
CTD PMID:31287969 NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,037,218...52,131,789
JBrowse link
amprenavir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 decreases expression EXP amprenavir results in decreased expression of NOS3 mRNA CTD PMID:16123675 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,156...6,228,938
JBrowse link
benzothiazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TPO thyroid peroxidase decreases activity EXP benzothiazole results in decreased activity of TPO protein CTD PMID:25953703 NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,408,943
JBrowse link
bis(2-chloroethyl) sulfide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADM adrenomedullin increases expression EXP Mustard Gas results in increased expression of ADM mRNA CTD PMID:18988085 NCBI chr 2:49,229,223...49,231,521
Ensembl chr 2:49,229,223...49,231,866
JBrowse link
G AIF1 allograft inflammatory factor 1 increases expression EXP Mustard Gas results in increased expression of AIF1 mRNA CTD PMID:18988085 NCBI chr 7:23,711,752...23,731,191
Ensembl chr 7:23,711,722...23,731,671
JBrowse link
G ANPEP alanyl aminopeptidase, membrane increases expression EXP Mustard Gas results in increased expression of ANPEP mRNA CTD PMID:18988085 NCBI chr 7:55,351,081...55,373,856
Ensembl chr 7:55,351,083...55,373,881
JBrowse link
G ANXA1 annexin A1 increases expression EXP Mustard Gas results in increased expression of ANXA1 mRNA CTD PMID:18988085 NCBI chr 1:226,414,200...226,431,963
Ensembl chr 1:226,414,307...226,432,287
JBrowse link
G ARG1 arginase 1 increases expression EXP Mustard Gas results in increased expression of ARG1 mRNA CTD PMID:18988085 NCBI chr 1:32,006,035...32,028,983
Ensembl chr 1:32,006,038...32,028,986
JBrowse link
G ATF2 activating transcription factor 2 affects expression EXP Mustard Gas affects the expression of ATF2 mRNA CTD PMID:18988085 NCBI chr15:80,984,969...81,076,573
Ensembl chr15:80,984,977...81,091,532
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP Mustard Gas results in decreased expression of BCL2 protein CTD PMID:9302645 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879
JBrowse link
G BIRC6 baculoviral IAP repeat containing 6 increases expression EXP Mustard Gas results in increased expression of BIRC6 mRNA CTD PMID:18988085 NCBI chr 3:107,012,967...107,269,370
Ensembl chr 3:107,013,424...107,269,409
JBrowse link
G BMP5 bone morphogenetic protein 5 decreases expression EXP Mustard Gas results in decreased expression of BMP5 mRNA CTD PMID:18988085 NCBI chr 7:25,344,924...25,468,430
Ensembl chr 7:25,344,822...25,470,470
JBrowse link
G C2 complement C2 increases expression EXP Mustard Gas results in increased expression of C2 mRNA CTD PMID:18988085 NCBI chr 7:24,020,590...24,034,042
Ensembl chr 7:23,995,982...24,034,040
JBrowse link
G C3 complement C3 increases expression EXP Mustard Gas results in increased expression of C3 mRNA CTD PMID:18988085 NCBI chr 2:72,431,470...72,471,622
Ensembl chr 2:72,431,499...72,528,112
JBrowse link
G C7 complement C7 increases expression EXP Mustard Gas results in increased expression of C7 mRNA CTD PMID:18988085 NCBI chr16:25,846,860...25,902,707
Ensembl chr16:25,843,101...25,953,574
JBrowse link
G CAPNS1 calpain small subunit 1 increases expression EXP Mustard Gas results in increased expression of CAPNS1 mRNA CTD PMID:18988085 NCBI chr 6:45,511,410...45,518,610
Ensembl chr 6:45,511,339...45,520,859
JBrowse link
G CASP3 caspase 3 increases expression EXP Mustard Gas results in increased expression of CASP3 mRNA CTD PMID:18988085 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CCL19 C-C motif chemokine ligand 19 increases expression EXP Mustard Gas results in increased expression of CCL19 mRNA CTD PMID:18988085 NCBI chr10:32,110,366...32,112,529
Ensembl chr10:32,110,064...32,112,739
JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 increases expression EXP Mustard Gas results in increased expression of CCL2 mRNA CTD PMID:18988085, PMID:27617619 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,028
JBrowse link
G CCL5 C-C motif chemokine ligand 5 increases expression EXP Mustard Gas results in increased expression of CCL5 mRNA CTD PMID:18988085 NCBI chr12:39,652,731...39,659,121
Ensembl chr12:39,648,598...39,659,118
JBrowse link
G CCN1 cellular communication network factor 1 increases expression EXP Mustard Gas results in increased expression of CCN1 mRNA CTD PMID:27617619 NCBI chr 4:130,392,404...130,395,179
Ensembl chr 4:130,392,404...130,395,150
JBrowse link
G CCN2 cellular communication network factor 2 increases expression EXP Mustard Gas results in increased expression of CCN2 mRNA CTD PMID:27617619 NCBI chr 1:31,674,398...31,677,697
Ensembl chr 1:31,673,798...31,677,696
JBrowse link
G CCR1 C-C motif chemokine receptor 1 increases expression EXP Mustard Gas results in increased expression of CCR1 mRNA CTD PMID:18988085 NCBI chr13:29,227,218...29,233,862
Ensembl chr13:29,227,220...29,233,960
JBrowse link
G CCR5 chemokine (C-C motif) receptor 5 decreases expression EXP Mustard Gas results in decreased expression of CCR5 mRNA CTD PMID:27617619 NCBI chr13:29,382,383...29,387,902
Ensembl chr13:29,383,303...29,387,902
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression EXP Mustard Gas results in increased expression of CDKN1A mRNA CTD PMID:27617619 NCBI chr 7:32,354,776...32,363,771
Ensembl chr 7:32,359,455...32,363,761
JBrowse link
G CFB complement factor B increases expression EXP Mustard Gas results in increased expression of BF mRNA CTD PMID:18988085 NCBI chr 7:24,034,077...24,040,523 JBrowse link
G CLDN1 claudin 1 decreases expression EXP Mustard Gas results in decreased expression of CLDN1 mRNA CTD PMID:18988085 NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,767...127,730,657
JBrowse link
G CLU clusterin increases expression EXP Mustard Gas results in increased expression of CLU mRNA CTD PMID:18988085 NCBI chr14:11,336,585...11,352,569
Ensembl chr14:11,336,590...11,352,475
JBrowse link
G CTNNA3 catenin alpha 3 decreases expression EXP Mustard Gas results in decreased expression of CTNNA3 mRNA CTD PMID:18988085 NCBI chr14:69,195,231...70,974,543
Ensembl chr14:69,200,215...70,938,204
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression EXP Mustard Gas results in increased expression of CXCL8 mRNA CTD PMID:12481301, PMID:18988085, PMID:27617619 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 increases expression EXP Mustard Gas results in increased expression of CXCR4 mRNA CTD PMID:18988085 NCBI chr15:15,663,652...15,666,706
Ensembl chr15:15,663,494...15,667,233
JBrowse link
G EGR1 early growth response 1 increases expression EXP Mustard Gas results in increased expression of EGR1 mRNA CTD PMID:18988085, PMID:27617619 NCBI chr 2:140,440,829...140,445,302
Ensembl chr 2:140,441,421...140,445,296
JBrowse link
G EPHA4 EPH receptor A4 decreases expression EXP Mustard Gas results in decreased expression of EPHA4 mRNA CTD PMID:18988085 NCBI chr15:123,350,867...123,501,872
Ensembl chr15:123,352,813...123,503,126
JBrowse link
G FBXO32 F-box protein 32 decreases expression EXP Mustard Gas results in decreased expression of FBXO32 mRNA CTD PMID:27617619 NCBI chr 4:15,895,875...15,925,929
Ensembl chr 4:15,895,351...15,930,940
JBrowse link
G FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) increases expression EXP Mustard Gas results in increased expression of FCNB mRNA CTD PMID:18988085 NCBI chr 1:274,106,276...274,111,970
Ensembl chr 1:274,103,877...274,111,970
JBrowse link
G FGF2 fibroblast growth factor 2 increases expression EXP Mustard Gas results in increased expression of FGF2 mRNA CTD PMID:27617619 NCBI chr 8:101,278,877...101,344,084
Ensembl chr 8:101,278,878...101,343,916
JBrowse link
G FGFR2 fibroblast growth factor receptor 2 decreases expression EXP Mustard Gas results in decreased expression of FGFR2 mRNA CTD PMID:18988085 NCBI chr14:131,183,095...131,285,001
Ensembl chr14:131,181,710...131,579,703
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Mustard Gas results in increased expression of FOS mRNA CTD PMID:18988085, PMID:27617619 NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
JBrowse link
G FXYD3 FXYD domain containing ion transport regulator 3 decreases expression EXP Mustard Gas results in decreased expression of FXYD3 mRNA CTD PMID:18988085 NCBI chr 6:44,647,771...44,654,377 JBrowse link
G GADD45A growth arrest and DNA damage inducible alpha increases expression EXP Mustard Gas results in increased expression of GADD45A mRNA CTD PMID:18988085 NCBI chr 6:144,940,702...144,944,089
Ensembl chr 6:144,940,702...144,944,249
JBrowse link
G GAPDH glyceraldehyde-3-phosphate dehydrogenase increases expression EXP Mustard Gas results in increased expression of GAPDH mRNA CTD PMID:18988085 NCBI chr 5:64,129,678...64,135,194
Ensembl chr 5:64,129,680...64,133,991
JBrowse link
G GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 increases expression EXP Mustard Gas results in increased expression of GUCY1B1 mRNA CTD PMID:18988085 NCBI chr 8:44,544,364...44,604,690
Ensembl chr 8:44,544,179...44,604,704
JBrowse link
G HBEGF heparin binding EGF like growth factor increases expression EXP Mustard Gas results in increased expression of HBEGF mRNA CTD PMID:27617619 NCBI chr 2:142,102,455...142,115,192
Ensembl chr 2:142,102,456...142,115,344
JBrowse link
G HMOX1 heme oxygenase 1 increases expression EXP Mustard Gas results in increased expression of HMOX1 mRNA CTD PMID:18988085
G HSPA1L heat shock protein family A (Hsp70) member 1 like increases expression EXP Mustard Gas results in increased expression of HSPA1L mRNA CTD PMID:18988085 NCBI chr 7:23,909,960...23,938,678
Ensembl chr 7:23,909,960...23,921,723
JBrowse link
G ICAM1 intercellular adhesion molecule 1 increases expression EXP Mustard Gas results in increased expression of ICAM1 mRNA CTD PMID:18988085 NCBI chr 2:69,097,136...69,107,722
Ensembl chr 2:69,097,122...69,108,205
JBrowse link
G IGF1 insulin like growth factor 1 increases expression EXP Mustard Gas results in increased expression of IGF1 mRNA CTD PMID:18988085 NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,037
JBrowse link
G IGFBP5 insulin like growth factor binding protein 5 decreases expression EXP Mustard Gas results in decreased expression of IGFBP5 mRNA CTD PMID:18988085 NCBI chr15:118,861,816...118,877,787
Ensembl chr15:118,857,479...118,878,522
JBrowse link
G IL1R1 interleukin 1 receptor type 1 increases expression EXP Mustard Gas results in increased expression of IL1R1 mRNA CTD PMID:18988085 NCBI chr 3:52,192,912...52,334,734
Ensembl chr 3:52,192,914...52,288,515
JBrowse link
G IL23A interleukin 23 subunit alpha decreases expression EXP Mustard Gas results in decreased expression of IL23A mRNA CTD PMID:27617619 NCBI chr 5:21,732,416...21,733,981
Ensembl chr 5:21,732,165...21,734,267
JBrowse link
G IL4R interleukin 4 receptor decreases expression EXP Mustard Gas results in decreased expression of IL4R mRNA CTD PMID:18988085 NCBI chr 3:19,526,343...19,576,792
Ensembl chr 3:19,523,564...19,576,544
JBrowse link
G IL6 interleukin 6 increases expression EXP Mustard Gas results in increased expression of IL6 mRNA CTD PMID:12481301 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G ITGA6 integrin subunit alpha 6 affects expression EXP Mustard Gas affects the expression of ITGA6 protein CTD PMID:9285538 NCBI chr15:78,504,108...78,591,779
Ensembl chr15:78,504,078...78,591,779
JBrowse link
G ITGB2 integrin subunit beta 2 increases expression EXP Mustard Gas results in increased expression of ITGB2 mRNA CTD PMID:18988085 NCBI chr13:207,514,281...207,544,108
Ensembl chr13:207,512,954...207,544,108
JBrowse link
G ITGB4 integrin subunit beta 4 affects expression EXP Mustard Gas affects the expression of ITGB4 protein CTD PMID:9285538 NCBI chr12:5,651,292...5,685,601
Ensembl chr12:5,651,292...5,685,611
JBrowse link
G LAMC2 laminin subunit gamma 2 decreases expression EXP Mustard Gas results in decreased expression of LAMC2 protein CTD PMID:9302645 NCBI chr 9:124,427,545...124,499,672
Ensembl chr 9:124,435,807...124,495,354
JBrowse link
G LDHA lactate dehydrogenase A increases expression EXP Mustard Gas results in increased expression of LDHA mRNA CTD PMID:18988085 NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,812,453...40,826,715
JBrowse link
G LOC100524373 platelet factor 4 increases expression EXP Mustard Gas results in increased expression of PF4 mRNA CTD PMID:18988085
G LOC110258578 interleukin-1 beta-like increases expression EXP Mustard Gas results in increased expression of IL1B mRNA CTD PMID:12481301
G LTF lactotransferrin increases expression EXP Mustard Gas results in increased expression of PLF mRNA CTD PMID:18988085 NCBI chr13:29,413,886...29,445,751
Ensembl chr13:29,413,886...29,445,737
JBrowse link
G MMP9 matrix metallopeptidase 9 increases expression EXP Mustard Gas results in increased expression of MMP9 mRNA CTD PMID:12481301 NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,175,056...48,188,264
JBrowse link
G MT3 metallothionein 3 decreases expression EXP Mustard Gas results in decreased expression of MT3 mRNA CTD PMID:18988085 NCBI chr 6:18,634,735...18,636,134
Ensembl chr 6:18,634,721...18,789,137
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor increases expression EXP Mustard Gas results in increased expression of MYC mRNA CTD PMID:27617619 NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,119...12,461,078
JBrowse link
G NPPB natriuretic peptide B increases expression EXP Mustard Gas results in increased expression of NPPB mRNA CTD PMID:27617619 NCBI chr 6:71,930,374...71,931,843
Ensembl chr 6:71,919,495...71,932,254
JBrowse link
G NR2F2 nuclear receptor subfamily 2 group F member 2 increases expression EXP Mustard Gas results in increased expression of NR2F2 mRNA CTD PMID:18988085 NCBI chr 7:83,076,119...83,090,250
Ensembl chr 7:83,076,144...83,090,536
JBrowse link
G NR4A3 nuclear receptor subfamily 4 group A member 3 increases expression EXP Mustard Gas results in increased expression of NR4A3 mRNA CTD PMID:18988085 NCBI chr 1:241,569,867...241,611,735
Ensembl chr 1:241,569,905...241,611,734
JBrowse link
G OSGIN1 oxidative stress induced growth inhibitor 1 increases expression EXP Mustard Gas results in increased expression of OSGIN1 mRNA CTD PMID:27617619 NCBI chr 6:4,642,762...4,656,113
Ensembl chr 6:4,642,762...4,675,813
JBrowse link
G PCNA proliferating cell nuclear antigen increases expression EXP Mustard Gas results in increased expression of PCNA protein CTD PMID:9302645 NCBI chr17:14,137,746...14,142,584
Ensembl chr17:14,125,814...14,185,276
JBrowse link
G PDGFRA platelet derived growth factor receptor alpha increases expression EXP Mustard Gas results in increased expression of PDGFRA mRNA CTD PMID:18988085 NCBI chr 8:40,966,568...41,021,440
Ensembl chr 8:40,967,493...41,021,442
JBrowse link
G PLAU plasminogen activator, urokinase increases expression EXP Mustard Gas results in increased expression of PLAU mRNA CTD PMID:18988085 NCBI chr14:76,629,313...76,635,173
Ensembl chr14:76,629,299...76,635,172
JBrowse link
G PLAUR plasminogen activator, urokinase receptor increases expression EXP Mustard Gas results in increased expression of PLAUR mRNA CTD PMID:18988085 NCBI chr 6:50,489,773...50,505,453
Ensembl chr 6:50,489,777...50,505,418
JBrowse link
G POU2F3 POU class 2 homeobox 3 decreases expression EXP Mustard Gas results in decreased expression of POU2F3 mRNA CTD PMID:18988085 NCBI chr 9:47,376,852...47,458,265
Ensembl chr 9:47,376,853...47,460,166
JBrowse link
G PPRC1 PPARG related coactivator 1 increases expression EXP Mustard Gas results in increased expression of PPRC1 mRNA CTD PMID:27617619 NCBI chr14:113,137,012...113,152,828
Ensembl chr14:113,137,037...113,152,834
JBrowse link
G RAPGEF4 Rap guanine nucleotide exchange factor 4 decreases expression EXP Mustard Gas results in decreased expression of RAPGEF4 mRNA CTD PMID:18988085 NCBI chr15:78,773,270...79,094,490
Ensembl chr15:78,773,285...79,095,041
JBrowse link
G RHBG Rh family B glycoprotein decreases expression EXP Mustard Gas results in decreased expression of RHBG mRNA CTD PMID:18988085 NCBI chr 4:93,694,259...93,708,055
Ensembl chr 4:93,694,264...93,707,822
JBrowse link
G SCARB2 scavenger receptor class B member 2 increases expression EXP Mustard Gas results in increased expression of SCARB2 mRNA CTD PMID:18988085 NCBI chr 8:71,838,395...71,910,461
Ensembl chr 8:71,838,788...71,940,607
JBrowse link
G SELE selectin E increases expression EXP Mustard Gas results in increased expression of SELE mRNA CTD PMID:18988085 NCBI chr 4:81,289,061...81,299,657 JBrowse link
G SERPINE1 serpin family E member 1 increases expression EXP Mustard Gas results in increased expression of SERPINE1 mRNA CTD PMID:27617619 NCBI chr 3:8,863,738...8,871,572
Ensembl chr 3:8,863,695...8,871,564
JBrowse link
G SHAS2 hyaluronan synthase 2 increases expression EXP Mustard Gas results in increased expression of SHAS2 mRNA CTD PMID:18988085 NCBI chr 4:17,583,154...17,613,524
Ensembl chr 4:17,596,472...17,675,586
JBrowse link
G SLC5A1 solute carrier family 5 member 1 decreases expression EXP Mustard Gas results in decreased expression of SLC5A1 mRNA CTD PMID:18988085 NCBI chr14:48,566,400...48,704,145
Ensembl chr14:48,566,343...48,705,841
JBrowse link
G SOD2 superoxide dismutase 2 increases expression EXP Mustard Gas results in increased expression of SOD2 mRNA CTD PMID:18988085 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,651,280...7,691,723
JBrowse link
G SPP1 secreted phosphoprotein 1 increases expression EXP Mustard Gas results in increased expression of SPP1 mRNA CTD PMID:18988085 NCBI chr 8:131,077,786...131,085,334
Ensembl chr 8:131,077,786...131,085,340
JBrowse link
G TBXAS1 thromboxane A synthase 1 increases expression EXP Mustard Gas results in increased expression of TBXAS1 mRNA CTD PMID:18988085 NCBI chr18:9,717,291...9,886,699
Ensembl chr18:9,717,292...9,886,682
JBrowse link
G TF transferrin decreases expression EXP Mustard Gas results in decreased expression of PICA mRNA CTD PMID:18988085 NCBI chr13:74,862,502...74,907,059 JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 increases expression EXP Mustard Gas results in increased expression of TIMP1 mRNA CTD PMID:18988085 NCBI chr  X:42,103,251...42,106,289
Ensembl chr  X:42,102,172...42,106,297
JBrowse link
G TLR2 toll like receptor 2 increases expression EXP Mustard Gas results in increased expression of TLR2 mRNA CTD PMID:18988085 NCBI chr 8:75,416,257...75,428,370
Ensembl chr 8:75,411,991...75,446,850
JBrowse link
G TLR4 toll like receptor 4 increases expression EXP Mustard Gas results in increased expression of TLR4 mRNA CTD PMID:18988085 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,059,004
JBrowse link
G TNC tenascin C increases expression EXP Mustard Gas results in increased expression of TNC mRNA CTD PMID:18988085 NCBI chr 1:255,533,235...255,630,381
Ensembl chr 1:255,532,449...255,630,377
JBrowse link
G TNF tumor necrosis factor increases expression EXP Mustard Gas results in increased expression of TNF mRNA CTD PMID:12481301 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
G TNXB tenascin XB decreases expression EXP Mustard Gas results in decreased expression of TNXB mRNA CTD PMID:18988085 NCBI chr 7:24,088,873...24,155,815 JBrowse link
G TP53 tumor protein p53 increases expression EXP Mustard Gas results in increased expression of TP53 protein CTD PMID:9302645 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,643...52,953,819
JBrowse link
G TXN thioredoxin increases expression EXP Mustard Gas results in increased expression of TXN mRNA CTD PMID:18988085 NCBI chr 1:251,264,180...251,278,000
Ensembl chr 1:251,263,175...251,277,988
JBrowse link
G TYRO3 TYRO3 protein tyrosine kinase decreases expression EXP Mustard Gas results in decreased expression of TYRO3 mRNA CTD PMID:18988085 NCBI chr 1:129,811,540...129,829,395
Ensembl chr 1:129,811,539...129,828,991
JBrowse link
G UGP2 UDP-glucose pyrophosphorylase 2 increases expression EXP Mustard Gas results in increased expression of UGP2 mRNA CTD PMID:18988085 NCBI chr 3:77,975,450...78,032,471
Ensembl chr 3:77,975,440...78,031,731
JBrowse link
G VAV3 vav guanine nucleotide exchange factor 3 decreases expression EXP Mustard Gas results in decreased expression of VAV3 mRNA CTD PMID:18988085 NCBI chr 4:111,825,071...112,202,833
Ensembl chr 4:111,824,896...112,202,825
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 increases expression EXP Mustard Gas results in increased expression of VCAM1 mRNA CTD PMID:18988085 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,908...117,511,226
JBrowse link
G YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon increases expression EXP Mustard Gas results in increased expression of YWHAE mRNA CTD PMID:18988085 NCBI chr12:47,601,133...47,645,327
Ensembl chr12:47,600,502...47,690,398
JBrowse link
capsazepine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TRPV1 transient receptor potential cation channel subfamily V member 1 multiple interactions EXP capsazepine inhibits the reaction [Sodium affects the reaction [TRPV1 protein results in increased abundance of Calcium]] CTD PMID:18230619 NCBI chr12:49,676,536...49,709,634
Ensembl chr12:49,677,291...49,701,325
JBrowse link
cefaloridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase decreases activity EXP Cephaloridine results in decreased activity of CAT protein CTD PMID:11039594 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
chlorpyrifos-methyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APEH acylaminoacyl-peptide hydrolase decreases activity EXP chlorpyrifos-methyl results in decreased activity of APEH protein CTD PMID:10953051 NCBI chr13:32,205,863...32,214,517
Ensembl chr13:32,205,609...32,214,523
JBrowse link
chondroitin sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FGF10 fibroblast growth factor 10 affects binding EXP [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF10 protein CTD PMID:14699094 NCBI chr16:28,695,465...28,779,953
Ensembl chr16:28,695,469...28,777,541
JBrowse link
G FGF18 fibroblast growth factor 18 affects binding EXP [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF18 protein CTD PMID:14699094 NCBI chr16:52,724,867...52,760,246
Ensembl chr16:52,725,356...52,760,236
JBrowse link
G FGF2 fibroblast growth factor 2 affects binding EXP [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF2 protein CTD PMID:14699094 NCBI chr 8:101,278,877...101,344,084
Ensembl chr 8:101,278,878...101,343,916
JBrowse link
G MDK midkine affects binding EXP [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to MDK protein CTD PMID:14699094 NCBI chr 2:16,130,787...16,133,791
Ensembl chr 2:16,130,782...16,133,510
JBrowse link
G PTN pleiotrophin affects binding EXP [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to PTN protein CTD PMID:14699094 NCBI chr18:12,219,708...12,309,045
Ensembl chr18:12,219,790...12,311,922
JBrowse link
cilastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 multiple interactions EXP Cilastatin inhibits the reaction [Cisplatin results in increased activity of CASP3 protein] CTD PMID:20435919 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CASP8 caspase 8 multiple interactions EXP Cilastatin inhibits the reaction [Cisplatin results in increased activity of CASP8 protein] CTD PMID:20435919 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,470
JBrowse link
G FASLG Fas ligand (TNF superfamily, member 6) multiple interactions EXP Cilastatin inhibits the reaction [Cisplatin affects the localization of FASLG protein] CTD PMID:20435919 NCBI chr 9:115,068,314...115,075,147
Ensembl chr 9:115,068,090...115,076,475
JBrowse link
copper(II) sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATOX1 antioxidant 1 copper chaperone increases expression EXP Copper Sulfate results in increased expression of ATOX1 mRNA CTD PMID:22585802 NCBI chr16:71,299,321...71,314,598 JBrowse link
G CCNB1 cyclin B1 increases secretion EXP Copper Sulfate results in increased secretion of CCNB1 protein CTD PMID:24521407 NCBI chr16:47,338,239...47,348,385
Ensembl chr16:47,338,110...47,348,381
JBrowse link
G COX17 cytochrome c oxidase copper chaperone COX17 decreases expression EXP Copper Sulfate results in decreased expression of COX17 mRNA CTD PMID:22585802 NCBI chr13:140,584,286...140,594,636
Ensembl chr13:140,584,363...140,614,159
JBrowse link
G GHRH growth hormone releasing hormone increases expression EXP Copper Sulfate results in increased expression of GHRH mRNA CTD PMID:21110139 NCBI chr17:40,386,725...40,398,312
Ensembl chr17:40,387,344...40,397,857
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 increases expression EXP Copper Sulfate results in increased expression of HSP90B1 mRNA CTD PMID:17464326 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,507...80,531,005
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Copper Sulfate results in increased expression of HSPA5 mRNA CTD PMID:17464326 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
G IGF1 insulin like growth factor 1 increases secretion EXP Copper Sulfate results in increased secretion of IGF1 protein CTD PMID:24521407 NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,037
JBrowse link
G SST somatostatin decreases expression EXP Copper Sulfate results in decreased expression of SST mRNA; Copper Sulfate results in decreased expression of SST protein CTD PMID:21110139 NCBI chr13:125,337,560...125,338,742
Ensembl chr13:125,337,417...125,338,850
JBrowse link
cysteamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FMO1 flavin containing dimethylaniline monoxygenase 1 increases metabolic processing EXP FMO1 protein results in increased metabolism of Cysteamine CTD PMID:6439199 NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,812,103...63,895,077
JBrowse link
dermatan sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FGF10 fibroblast growth factor 10 affects binding EXP [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF10 protein CTD PMID:14699094 NCBI chr16:28,695,465...28,779,953
Ensembl chr16:28,695,469...28,777,541
JBrowse link
G FGF18 fibroblast growth factor 18 affects binding EXP [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF18 protein CTD PMID:14699094 NCBI chr16:52,724,867...52,760,246
Ensembl chr16:52,725,356...52,760,236
JBrowse link
G FGF2 fibroblast growth factor 2 affects binding EXP [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF2 protein CTD PMID:14699094 NCBI chr 8:101,278,877...101,344,084
Ensembl chr 8:101,278,878...101,343,916
JBrowse link
G MDK midkine affects binding EXP [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to MDK protein CTD PMID:14699094 NCBI chr 2:16,130,787...16,133,791
Ensembl chr 2:16,130,782...16,133,510
JBrowse link
G PTN pleiotrophin affects binding EXP [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to PTN protein CTD PMID:14699094 NCBI chr18:12,219,708...12,309,045
Ensembl chr18:12,219,790...12,311,922
JBrowse link
dextran sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP1 caspase 1, apoptosis-related cysteine peptidase multiple interactions
increases expression
EXP [Dextran Sulfate co-treated with Zearalenone] results in increased expression of CASP1 mRNA; [Dextran Sulfate co-treated with Zearalenone] results in increased expression of CASP1 protein; Zearalenone inhibits the reaction [Dextran Sulfate results in increased expression of CASP1 mRNA]
Dextran Sulfate results in increased expression of CASP1 mRNA; Dextran Sulfate results in increased expression of CASP1 protein
CTD PMID:30270565 NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328
JBrowse link
G IL18 interleukin 18 increases expression
multiple interactions
EXP Dextran Sulfate results in increased expression of IL18 mRNA
[Dextran Sulfate co-treated with Zearalenone] results in increased expression of IL18 mRNA; Dextran Sulfate inhibits the reaction [Zearalenone results in increased expression of IL18 mRNA]; Zearalenone inhibits the reaction [Dextran Sulfate results in increased expression of IL18 mRNA]
CTD PMID:30270565 NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,966...39,873,300
JBrowse link
G LOC100522011 apoptosis-associated speck-like protein containing a CARD multiple interactions
increases expression
EXP [Dextran Sulfate co-treated with Zearalenone] results in increased expression of PYCARD mRNA; [Dextran Sulfate co-treated with Zearalenone] results in increased expression of PYCARD protein
Dextran Sulfate results in increased expression of PYCARD mRNA; Dextran Sulfate results in increased expression of PYCARD protein
CTD PMID:30270565 NCBI chr 3:17,305,921...17,307,521
Ensembl chr 3:17,306,179...17,307,512
JBrowse link
G LOC110258578 interleukin-1 beta-like multiple interactions
increases expression
EXP [Dextran Sulfate co-treated with Zearalenone] results in increased expression of IL1B mRNA; Dextran Sulfate inhibits the reaction [Zearalenone results in increased expression of IL1B mRNA]; Zearalenone inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA] CTD PMID:30270565
G NLRP3 NLR family pyrin domain containing 3 multiple interactions
increases expression
EXP [Dextran Sulfate co-treated with Zearalenone] results in increased expression of NLRP3 mRNA; [Dextran Sulfate co-treated with Zearalenone] results in increased expression of NLRP3 protein; Dextran Sulfate inhibits the reaction [Zearalenone results in increased expression of NLRP3 mRNA]; Zearalenone inhibits the reaction [Dextran Sulfate results in increased expression of NLRP3 mRNA]; Zearalenone inhibits the reaction [Dextran Sulfate results in increased expression of NLRP3 protein]
Dextran Sulfate results in increased expression of NLRP3 mRNA; Dextran Sulfate results in increased expression of NLRP3 protein
CTD PMID:30270565 NCBI chr 2:56,892,241...56,977,412
Ensembl chr 2:56,892,242...56,977,234
JBrowse link
diazinon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase decreases activity EXP Diazinon results in decreased activity of ACHE protein CTD PMID:21467751 NCBI chr 3:8,732,451...8,738,274
Ensembl chr 3:8,732,324...8,739,149
JBrowse link
diethyldithiocarbamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G POMC proopiomelanocortin multiple interactions EXP Ditiocarb promotes the reaction [Sodium Selenite inhibits the reaction [POMC protein results in increased secretion of Hydrocortisone]] CTD PMID:21466817 NCBI chr 3:113,661,712...113,668,558 JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions
decreases activity
EXP SOD1 protein affects the susceptibility to [Ditiocarb co-treated with 6-anilino-5,8-quinolinedione]
Ditiocarb results in decreased activity of SOD1 protein
CTD PMID:11861319 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
dimercaprol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin multiple interactions EXP Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS protein results in increased uptake of 2-(methylamino)isobutyric acid]] CTD PMID:1928324 NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841
JBrowse link
disulfiram term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 multiple interactions EXP Disulfiram inhibits the reaction [4-xylene results in increased activity of CYP2E1 protein]; Disulfiram inhibits the reaction [Toluene results in increased activity of CYP2E1 protein] CTD PMID:12781212 NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,818
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP Disulfiram inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species] CTD PMID:10975995 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
estrone 3-sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1A2 solute carrier organic anion transporter family member 1A2 increases uptake
multiple interactions
EXP SLCO1A2 protein results in increased uptake of estrone sulfate
Amoxicillin inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; cefquinome inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Chlortetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Clarithromycin inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; daidzein inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Doxycycline inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Erythromycin inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Genistein inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; naringin inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Oxytetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Penicillins inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Tetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; tilmicosin inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Tylosin inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]
CTD PMID:31287969 NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,037,218...52,131,789
JBrowse link
fenbendazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 affects expression EXP Fenbendazole affects the expression of ABCB1 mRNA CTD PMID:26366864 NCBI chr 9:93,049,955...93,146,469 JBrowse link
G CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 affects expression EXP Fenbendazole affects the expression of CYP1A2 mRNA CTD PMID:26366864 NCBI chr 7:58,779,529...58,786,155
Ensembl chr 7:58,779,475...58,786,100
JBrowse link
G CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 affects expression EXP Fenbendazole affects the expression of CYP2E1 mRNA CTD PMID:26366864 NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,818
JBrowse link
G CYP3A22 cytochrome P450, subfamily IIIA, polypeptide 22 affects expression EXP Fenbendazole affects the expression of CYP3A22 mRNA CTD PMID:26366864 NCBI chr 3:6,617,256...6,665,179
Ensembl chr 3:6,615,343...6,822,817
JBrowse link
G CYP3A29 cytochrome P450 3A29 affects expression EXP Fenbendazole affects the expression of CYP3A29 mRNA CTD PMID:26366864 NCBI chr 3:6,738,502...6,778,121 JBrowse link
G SULT1A3 sulfotransferase family 1A member 3 affects expression EXP Fenbendazole affects the expression of SULT1A1 mRNA CTD PMID:26366864 NCBI chr 3:18,351,205...18,354,653
Ensembl chr 3:18,351,621...18,354,651
JBrowse link
fucoidan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNF tumor necrosis factor multiple interactions EXP [laminaran co-treated with fucoidan co-treated with Minerals] promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:21948611 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
fulvestrant term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HOXA10 homeobox A10 decreases expression
multiple interactions
EXP Fulvestrant results in decreased expression of HOXA10 mRNA
Fulvestrant inhibits the reaction [Estradiol results in increased expression of HOXA10 mRNA]
CTD PMID:21705055 NCBI chr18:45,393,525...45,403,259
Ensembl chr18:45,393,712...45,403,257
JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions EXP Fulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of NOS3 protein]; Fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in increased phosphorylation of NOS3 protein] CTD PMID:17618301 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,156...6,228,938
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Fulvestrant inhibits the reaction [Estradiol results in increased expression of PTGS2 mRNA] CTD PMID:21705055 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,013...127,858,884
JBrowse link
glutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions EXP Glutathione inhibits the reaction [Cadmium Chloride results in decreased activity of IDH2 protein]; Glutathione inhibits the reaction [Cadmium results in decreased activity of IDH2 protein] CTD PMID:16785314 NCBI chr 7:55,654,298...55,675,571
Ensembl chr 7:55,651,606...55,681,426
JBrowse link
G LOC100739163 glutathione S-transferase P-like multiple interactions EXP GSTP1 protein affects the metabolism of [monobromobimane co-treated with Glutathione] CTD PMID:14573868 NCBI chr 2:4,978,761...4,982,233 JBrowse link
glyburide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 multiple interactions EXP Glyburide inhibits the reaction [Carvedilol results in decreased expression of EDN1 protein] CTD PMID:18840580 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
heparin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PSP-I porcine seminal protein I multiple interactions EXP zinc chloride promotes the reaction [PSP-I protein binds to Heparin]; Zinc promotes the reaction [PSP-I protein binds to Heparin] CTD PMID:16819821 NCBI chr14:132,302,376...132,309,388
Ensembl chr14:132,274,241...132,320,855
JBrowse link
L-1,4-dithiothreitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH7A1 aldehyde dehydrogenase 7 family member A1 multiple interactions EXP Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of ALDH7A1 protein] CTD PMID:21296058 NCBI chr 2:129,663,226...129,709,728
Ensembl chr 2:129,662,296...129,713,729
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Dithiothreitol metabolite results in increased expression of HSPA5 protein CTD PMID:17416481 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions EXP Dithiothreitol inhibits the reaction [Cadmium Chloride results in decreased activity of IDH2 protein]; Dithiothreitol inhibits the reaction [Cadmium results in decreased activity of IDH2 protein] CTD PMID:16785314 NCBI chr 7:55,654,298...55,675,571
Ensembl chr 7:55,651,606...55,681,426
JBrowse link
lipoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions EXP Thioctic Acid inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein] CTD PMID:24512358 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
malathion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MT-CO1 mitochondrially encoded cytochrome c oxidase I affects expression EXP Malathion affects the expression of COX1 mRNA CTD PMID:17454254 NCBI chr MT:6,511...8,055
Ensembl chr MT:6,511...8,055
JBrowse link
G MT-CO3 mitochondrially encoded cytochrome c oxidase III affects expression EXP Malathion affects the expression of COX3 mRNA CTD PMID:17454254 NCBI chr MT:9,800...10,583
Ensembl chr MT:9,800...10,583
JBrowse link
mercaptoethanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH7A1 aldehyde dehydrogenase 7 family member A1 multiple interactions EXP Mercaptoethanol inhibits the reaction [Hydrogen Peroxide results in decreased activity of ALDH7A1 protein] CTD PMID:21296058 NCBI chr 2:129,663,226...129,709,728
Ensembl chr 2:129,662,296...129,713,729
JBrowse link
mesulergine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HTR2C 5-hydroxytryptamine receptor 2C affects binding
multiple interactions
EXP mesulergine binds to HTR2C protein
8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine inhibits the reaction [mesulergine binds to HTR2C protein]
CTD PMID:11927170 NCBI chr  X:94,053,415...94,313,352
Ensembl chr  X:94,053,456...94,313,356
JBrowse link
methimazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FMO1 flavin containing dimethylaniline monoxygenase 1 increases metabolic processing EXP FMO1 protein results in increased metabolism of Methimazole CTD PMID:6439199 NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,812,103...63,895,077
JBrowse link
G TPO thyroid peroxidase decreases activity EXP Methimazole results in decreased activity of TPO protein CTD PMID:23959146 NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,408,943
JBrowse link
ML-7 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MYL9 myosin light chain 9 decreases phosphorylation EXP ML 7 results in decreased phosphorylation of MYL9 protein CTD PMID:10942722 NCBI chr17:39,788,165...39,795,240
Ensembl chr17:39,788,199...39,795,296
JBrowse link
G MYLK myosin light chain kinase multiple interactions EXP [ML 7 results in decreased activity of MYLK protein] which results in decreased uptake of Calcium CTD PMID:9506478 NCBI chr13:136,509,878...136,809,674
Ensembl chr13:136,508,808...136,809,674
JBrowse link
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CREB1 cAMP responsive element binding protein 1 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Brimonidine Tartrate results in increased phosphorylation of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein] CTD PMID:17680988 NCBI chr15:110,705,548...110,773,037
Ensembl chr15:110,697,408...110,771,755
JBrowse link
G IL6 interleukin 6 decreases expression
multiple interactions
EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased expression of IL6 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of IL6 protein]
CTD PMID:24105867 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G PRKACB protein kinase cAMP-activated catalytic subunit beta multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of PRKACG protein] CTD PMID:24105867 NCBI chr 6:129,520,397...129,636,207
Ensembl chr 6:129,519,962...129,635,517
JBrowse link
N-acetyl-L-cysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium results in increased expression of BAX protein] CTD PMID:19135140 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions EXP [Acetylcysteine co-treated with fumonisin B1 co-treated with deoxynivalenol] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with fumonisin B1] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with Zearalenone co-treated with deoxynivalenol] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with Zearalenone] results in increased expression of BCL2 protein; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [Cadmium results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone results in decreased expression of BCL2 mRNA]] CTD PMID:19135140, PMID:29109043 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879
JBrowse link
G BMP15 bone morphogenetic protein 15 multiple interactions EXP Acetylcysteine inhibits the reaction [Zearalenone results in decreased expression of BMP15 mRNA] CTD PMID:26386189 NCBI chr  X:44,613,122...44,620,575
Ensembl chr  X:44,613,122...44,620,575
JBrowse link
G CASP3 caspase 3 multiple interactions EXP [Acetylcysteine co-treated with Zearalenone] results in decreased expression of CASP3 protein; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] promotes the reaction [deoxynivalenol results in increased expression of CASP3 protein]]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [[fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [deoxynivalenol results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [deoxynivalenol results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [deoxynivalenol results in increased expression of CASP3 protein]] CTD PMID:17383151, PMID:19135140, PMID:29109043 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CASP9 caspase 9 multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium results in increased activity of CASP9 protein] CTD PMID:19135140 NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,515...74,730,092
JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 multiple interactions EXP Acetylcysteine inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA] CTD PMID:19265715 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,028
JBrowse link
G CYCS cytochrome c, somatic multiple interactions EXP Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [[Zearalenone co-treated with fumonisin B1] results in increased expression of CYCS mRNA]]; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CYCS mRNA]]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CYCS mRNA]]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [[deoxynivalenol co-treated with fumonisin B1] results in increased expression of CYCS mRNA]] CTD PMID:29109043 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA] CTD PMID:18086661 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,441...22,791,134
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA] CTD PMID:18086661 NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions EXP Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]] CTD PMID:29109043 NCBI chr15:54,382,564...54,433,989
Ensembl chr15:54,382,567...54,433,989
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HSP90B1 mRNA] CTD PMID:18086661 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,507...80,531,005
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 mRNA] CTD PMID:18086661 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:17383151 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,172,200
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK9 protein] CTD PMID:17383151 NCBI chr 2:78,338,466...78,399,108
Ensembl chr 2:78,338,369...78,399,105
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor multiple interactions EXP Acetylcysteine inhibits the reaction [Cisplatin results in increased expression of MYC] CTD PMID:12712633 NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,119...12,461,078
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions EXP Acetylcysteine inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein] CTD PMID:24512358 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
G PTX3 pentraxin 3 multiple interactions EXP Acetylcysteine inhibits the reaction [Zearalenone results in decreased expression of PTX3 mRNA] CTD PMID:26386189 NCBI chr13:97,273,594...97,279,570
Ensembl chr13:97,273,594...97,279,569
JBrowse link
G TNFAIP6 TNF alpha induced protein 6 multiple interactions EXP Acetylcysteine inhibits the reaction [Zearalenone results in decreased expression of TNFAIP6 mRNA] CTD PMID:26386189 NCBI chr15:862,013...881,352
Ensembl chr15:862,013...881,461
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone results in increased expression of TP53 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [fumonisin B1 results in increased expression of TP53 mRNA]]; Acetylcysteine promotes the reaction [deoxynivalenol inhibits the reaction [Zearalenone results in increased expression of TP53 mRNA]] CTD PMID:29109043 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,643...52,953,819
JBrowse link
G ZP3 zona pellucida glycoprotein 3 multiple interactions EXP Acetylcysteine inhibits the reaction [Zearalenone results in decreased expression of ZP3 mRNA] CTD PMID:26386189 NCBI chr 3:9,934,760...9,944,924
Ensembl chr 3:9,934,761...9,944,941
JBrowse link
nimesulide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP nimesulide inhibits the reaction [Hydrogen Peroxide results in increased expression of HSPA5 protein] CTD PMID:20665602 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
omega-conotoxin GVIA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCYAP1 adenylate cyclase activating polypeptide 1 multiple interactions EXP omega-Conotoxin GVIA inhibits the reaction [ADCYAP1 protein alternative form results in decreased susceptibility to 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] CTD PMID:14662737 NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,630...105,422,295
JBrowse link
G OPRM1 opioid receptor mu 1 multiple interactions EXP omega-Conotoxin GVIA inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein results in increased transport of Barium]] CTD PMID:12031848 NCBI chr 1:12,634,125...12,702,295
Ensembl chr 1:12,528,672...12,702,443
JBrowse link
G VIP vasoactive intestinal peptide multiple interactions EXP omega-Conotoxin GVIA inhibits the reaction [VIP protein results in decreased susceptibility to 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] CTD PMID:14662737 NCBI chr 1:13,611,786...13,620,250
Ensembl chr 1:13,611,311...13,620,269
JBrowse link
pioglitazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 increases expression
affects localization
EXP Pioglitazone results in increased expression of ABCA1 mRNA
Pioglitazone affects the localization of ABCA1 protein
CTD PMID:16530456 NCBI chr 1:246,144,277...246,278,492
Ensembl chr 1:246,144,277...246,278,492
JBrowse link
G APOA1 apolipoprotein A1 multiple interactions
increases secretion
EXP Pioglitazone promotes the reaction [APOA1 protein results in increased transport of Cholesterol]
Pioglitazone results in increased secretion of APOA1 protein
CTD PMID:16530456 NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,393...44,218,978
JBrowse link
G LIPG lipase G, endothelial type decreases expression EXP Pioglitazone results in decreased expression of LIPG mRNA; Pioglitazone results in decreased expression of LIPG protein CTD PMID:15953354 NCBI chr 1:99,081,940...99,110,671
Ensembl chr 1:99,081,938...99,110,876
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP Pioglitazone promotes the reaction [Troglitazone results in increased phosphorylation of MAPK1 protein] CTD PMID:17065204 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP Pioglitazone promotes the reaction [Troglitazone results in increased phosphorylation of MAPK3 protein] CTD PMID:17065204 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions
increases activity
EXP Troglitazone inhibits the reaction [Pioglitazone results in increased activity of PPARG protein] CTD PMID:17065204 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,655...68,433,947
JBrowse link
G SCARB1 scavenger receptor class B member 1 increases expression
affects localization
EXP Pioglitazone results in increased expression of SCARB1 mRNA
Pioglitazone affects the localization of SCARB1 protein
CTD PMID:16530456 NCBI chr14:28,301,421...28,393,568
Ensembl chr14:28,301,294...28,393,565
JBrowse link
raloxifene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 decreases phosphorylation EXP Raloxifene Hydrochloride results in decreased phosphorylation of AKT1 protein CTD PMID:17348974
G CAV1 caveolin 1 increases expression EXP Raloxifene Hydrochloride results in increased expression of CAV1 protein CTD PMID:16680078 NCBI chr18:29,648,120...29,682,451
Ensembl chr18:29,649,992...29,682,465
JBrowse link
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation EXP Raloxifene Hydrochloride results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:17348974 NCBI chr15:48,423,001...48,443,373
Ensembl chr15:48,422,816...48,443,399
JBrowse link
G ESR1 estrogen receptor 1 decreases expression
affects expression
affects binding
EXP Raloxifene Hydrochloride results in decreased expression of ESR1 protein alternative form
Raloxifene Hydrochloride affects the expression of ESR1 protein
Raloxifene Hydrochloride metabolite binds to ESR1 protein
CTD PMID:15653758, PMID:16680078, PMID:16790557, PMID:17348974 NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363
JBrowse link
G ESR2 estrogen receptor 2 affects expression EXP Raloxifene Hydrochloride affects the expression of ESR2 protein CTD PMID:15653758, PMID:16680078 NCBI chr 1:193,823,666...193,907,330
Ensembl chr 1:193,722,164...193,906,565
JBrowse link
G F3 coagulation factor III, tissue factor affects expression EXP Raloxifene Hydrochloride affects the expression of F3 protein CTD PMID:15964915 NCBI chr 4:122,827,018...122,837,673
Ensembl chr 4:122,826,992...122,837,672
JBrowse link
G MMP2 matrix metallopeptidase 2 affects secretion EXP Raloxifene Hydrochloride affects the secretion of MMP2 protein CTD PMID:15653758 NCBI chr 6:30,059,247...30,087,031
Ensembl chr 6:30,058,594...30,086,982
JBrowse link
G NOS3 nitric oxide synthase 3 increases phosphorylation
affects expression
multiple interactions
decreases expression
EXP Raloxifene Hydrochloride results in increased phosphorylation of NOS3 protein
Raloxifene Hydrochloride affects the expression of NOS3 mRNA
Fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in increased phosphorylation of NOS3 protein]
Raloxifene Hydrochloride results in decreased expression of NOS3 protein
CTD PMID:15653758, PMID:16680078, PMID:17618301 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,156...6,228,938
JBrowse link
G PDGFB platelet derived growth factor subunit B multiple interactions EXP Raloxifene Hydrochloride affects the secretion of [PDGFB protein binds to PDGFB protein] CTD PMID:15653758 Ensembl chr 5:8,986,461...9,007,446 JBrowse link
G SELP selectin P affects expression EXP Raloxifene Hydrochloride affects the expression of SELP protein CTD PMID:15964915 NCBI chr 4:81,376,804...81,401,240
Ensembl chr 4:81,365,740...81,406,203
JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b increases expression EXP Raloxifene Hydrochloride results in increased expression of TNFRSF11B protein CTD PMID:15713688 NCBI chr 4:19,850,212...19,879,132 JBrowse link
ritonavir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 multiple interactions
decreases expression
EXP Masoprocol inhibits the reaction [Ritonavir results in decreased expression of NOS3 mRNA]; Masoprocol inhibits the reaction [Ritonavir results in decreased expression of NOS3 protein]; Ritonavir results in decreased expression of and results in decreased activity of NOS3 protein
Ritonavir results in decreased expression of NOS3 mRNA; Ritonavir results in decreased expression of NOS3 protein
CTD PMID:15681703, PMID:16123675, PMID:22037733 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,156...6,228,938
JBrowse link
S-adenosyl-L-methioninate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMT catechol-O-methyltransferase multiple interactions EXP [S-Adenosylmethionine analog co-treated with COMT protein] results in increased methylation of catechol CTD PMID:20196537 NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,133...51,403,998
JBrowse link
S-adenosyl-L-methionine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMT catechol-O-methyltransferase multiple interactions EXP [S-Adenosylmethionine analog co-treated with COMT protein] results in increased methylation of catechol CTD PMID:20196537 NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,133...51,403,998
JBrowse link
S-butyl-DL-homocysteine (S,R)-sulfoximine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions
decreases activity
EXP Buthionine Sulfoximine inhibits the reaction [sulforafan inhibits the reaction [Cisplatin results in decreased activity of GCLC protein]]
Buthionine Sulfoximine results in decreased activity of GCLC protein
CTD PMID:20732396 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,564...27,253,535
JBrowse link
S-nitrosoglutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP AKT1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein] CTD PMID:11514583
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression
EXP 2,3-dimethoxy-1,4-naphthoquinone inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; AKT1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; Genistein inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; PIK3R1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; Wortmannin inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein] CTD PMID:11514583 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,181...190,674,850
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions EXP PIK3R1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein] CTD PMID:11514583 NCBI chr16:46,434,757...46,523,626
Ensembl chr16:46,434,873...46,523,609
JBrowse link
salubrinal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EIF2A eukaryotic translation initiation factor 2A increases phosphorylation EXP salubrinal results in increased phosphorylation of EIF2A protein CTD PMID:17464326 NCBI chr13:90,761,453...90,804,274
Ensembl chr13:90,761,465...90,804,276
JBrowse link
SB 203580 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 chemokine (C-C motif) ligand 2 multiple interactions EXP SB 203580 inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]; SB 203580 inhibits the reaction [titanium dioxide results in increased expression of CCL2 mRNA] CTD PMID:19265715, PMID:23380242 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,028
JBrowse link
G STAT1 signal transducer and activator of transcription 1 multiple interactions EXP SB 203580 inhibits the reaction [Cadmium results in increased phosphorylation of STAT1 protein] CTD PMID:21783819 NCBI chr15:95,593,201...95,646,324
Ensembl chr15:95,593,211...95,646,260
JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions EXP SB 203580 inhibits the reaction [Cadmium results in increased phosphorylation of STAT3 protein] CTD PMID:21783819 NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,993
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions EXP SB 203580 inhibits the reaction [titanium dioxide results in increased expression of VCAM1 mRNA] CTD PMID:23380242 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,908...117,511,226
JBrowse link
sulfamethoxazole hydroxylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALR calreticulin increases expression EXP sulfamethoxazole hydroxylamine results in increased expression of CALR protein CTD PMID:16005169 NCBI chr 2:66,098,263...66,102,074
Ensembl chr 2:66,098,225...66,102,340
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 decreases expression EXP sulfamethoxazole hydroxylamine results in decreased expression of HSP90B1 protein CTD PMID:16005169 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,507...80,531,005
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP sulfamethoxazole hydroxylamine results in increased expression of HSPA5 protein CTD PMID:16005169 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
sulforaphane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 chemokine (C-C motif) ligand 2 multiple interactions EXP sulforafan inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA] CTD PMID:21130106 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,028
JBrowse link
G FIS1 fission, mitochondrial 1 decreases expression EXP sulforafan results in decreased expression of FIS1 protein CTD PMID:27993529 NCBI chr 3:8,938,250...8,942,102
Ensembl chr 3:8,931,104...8,941,865
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression
increases activity
multiple interactions
EXP sulforafan results in increased expression of GCLC mRNA
sulforafan results in increased activity of GCLC protein
Buthionine Sulfoximine inhibits the reaction [sulforafan inhibits the reaction [Cisplatin results in decreased activity of GCLC protein]]; ochratoxin A inhibits the reaction [sulforafan results in increased expression of GCLC mRNA]; sulforafan inhibits the reaction [Cisplatin results in decreased activity of GCLC protein]
CTD PMID:18547363, PMID:20732396 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,564...27,253,535
JBrowse link
G GSTA1 glutathione S-transferase alpha 1 multiple interactions
increases expression
EXP ochratoxin A inhibits the reaction [sulforafan results in increased expression of GSTA1 mRNA] CTD PMID:18547363 NCBI chr 7:46,538,743...46,550,781
Ensembl chr 7:46,538,032...46,567,728
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression
EXP NFE2L2 protein affects the reaction [sulforafan results in increased expression of HMOX1 protein] CTD PMID:28710020
G MT-ND1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 increases expression EXP sulforafan results in increased expression of ND1 protein CTD PMID:27993529 NCBI chr MT:3,922...4,876
Ensembl chr MT:3,922...4,876
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions
increases activity
affects localization
increases expression
EXP NFE2L2 protein affects the reaction [sulforafan results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [sulforafan results in increased expression of NQO1 protein]; ochratoxin A inhibits the reaction [sulforafan affects the localization of NFE2L2 protein]; ochratoxin A inhibits the reaction [sulforafan results in increased activity of NFE2L2 protein]; ochratoxin A inhibits the reaction [sulforafan results in increased expression of NFE2L2 mRNA]; sulforafan results in increased expression of and results in increased activity of NFE2L2 protein CTD PMID:18547363, PMID:19913604, PMID:21130106, PMID:28710020 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
increases activity
EXP Dicumarol inhibits the reaction [sulforafan inhibits the reaction [Cisplatin results in decreased activity of NQO1 protein]]; NFE2L2 protein affects the reaction [sulforafan results in increased expression of NQO1 protein]; sulforafan inhibits the reaction [Cisplatin results in decreased activity of NQO1 protein]
sulforafan results in increased activity of NQO1 protein
CTD PMID:20732396, PMID:28710020 NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,769...17,302,590
JBrowse link
G NRF1 nuclear respiratory factor 1 increases expression EXP sulforafan results in increased expression of NRF1 protein CTD PMID:27993529 NCBI chr18:19,008,408...19,142,678
Ensembl chr18:18,998,905...19,142,628
JBrowse link
G TFAM transcription factor A, mitochondrial increases expression EXP sulforafan results in increased expression of TFAM protein CTD PMID:27993529 NCBI chr14:92,261,713...92,279,731
Ensembl chr14:92,259,403...92,279,550
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions EXP sulforafan inhibits the reaction [ochratoxin A results in increased expression of TGFB1 mRNA] CTD PMID:28710020 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,169...49,349,048
JBrowse link
sulindac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLA2G1B phospholipase A2 group IB multiple interactions EXP Sulindac promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA] CTD PMID:10706128 NCBI chr14:40,314,520...40,322,315
Ensembl chr14:40,314,444...40,322,319
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Sulindac promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA] CTD PMID:10706128 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,013...127,858,884
JBrowse link
taurocholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 increases transport EXP ABCB11 protein results in increased transport of Taurocholic Acid CTD PMID:21056966 NCBI chr15:75,402,296...75,487,092
Ensembl chr15:75,400,766...75,486,403
JBrowse link
G SLCO1A2 solute carrier organic anion transporter family member 1A2 increases uptake
multiple interactions
EXP SLCO1A2 protein results in increased uptake of Taurocholic Acid
Amoxicillin inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; cefquinome inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; Clarithromycin inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; daidzein inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; Doxycycline inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; Erythromycin inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; Genistein inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; naringin inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; Oxytetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; Penicillins inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; Tetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; tilmicosin inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; Tylosin inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]
CTD PMID:31287969 NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,037,218...52,131,789
JBrowse link
thymol sulfate(1-) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RYR1 ryanodine receptor 1 increases activity EXP Thymol results in increased activity of RYR1 protein CTD PMID:17641978 NCBI chr 6:47,339,759...47,458,457 JBrowse link
troglitazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 decreases expression
affects localization
EXP Troglitazone results in decreased expression of ABCA1 mRNA
Troglitazone affects the localization of ABCA1 protein
CTD PMID:16530456 NCBI chr 1:246,144,277...246,278,492
Ensembl chr 1:246,144,277...246,278,492
JBrowse link
G APOA1 apolipoprotein A1 increases secretion
decreases expression
multiple interactions
EXP Troglitazone results in increased secretion of APOA1 protein
Troglitazone results in decreased expression of APOA1 mRNA
Troglitazone promotes the reaction [APOA1 protein results in increased transport of Cholesterol]
CTD PMID:16530456 NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,393...44,218,978
JBrowse link
G CASP3 caspase 3 multiple interactions EXP [Troglitazone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of CASP3 mRNA CTD PMID:30481989 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CEBPA CCAAT enhancer binding protein alpha increases expression
multiple interactions
EXP Troglitazone results in increased expression of CEBPA mRNA
Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of CEBPA mRNA]
CTD PMID:11225715, PMID:30481989 NCBI chr 6:43,083,200...43,085,884
Ensembl chr 6:43,083,203...43,085,836
JBrowse link
G CTNNB1 catenin beta 1 multiple interactions EXP Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of CTNNB1 mRNA] CTD PMID:30481989 NCBI chr13:25,163,550...25,208,314
Ensembl chr13:25,137,173...25,208,311
JBrowse link
G CYP17A1 cytochrome P450 17A1 multiple interactions EXP Troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased expression of CYP17A1 mRNA]; Troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased expression of CYP17A1 protein modified form] CTD PMID:11889176 NCBI chr14:113,805,616...113,820,445
Ensembl chr14:113,805,611...113,812,041
JBrowse link
G FABP4 fatty acid binding protein 4, adipocyte multiple interactions EXP Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of FABP4 mRNA] CTD PMID:30481989 NCBI chr 4:55,096,400...55,101,209
Ensembl chr 4:55,096,404...55,101,897
JBrowse link
G IGF1 insulin like growth factor 1 multiple interactions EXP Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of IGF1 mRNA] CTD PMID:30481989 NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,037
JBrowse link
G IGF1R insulin like growth factor 1 receptor multiple interactions EXP Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of IGF1R mRNA] CTD PMID:30481989 NCBI chr 1:137,383,623...137,691,038
Ensembl chr 1:137,387,925...137,690,666
JBrowse link
G INS insulin multiple interactions EXP Troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased abundance of Androstenedione]; Troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased abundance of Testosterone]; Troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased expression of CYP17A1 mRNA]; Troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased expression of CYP17A1 protein modified form] CTD PMID:11889176 NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841
JBrowse link
G LHB luteinizing hormone subunit beta multiple interactions EXP Troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased abundance of Androstenedione]; Troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased abundance of Testosterone]; Troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased expression of CYP17A1 mRNA]; Troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased expression of CYP17A1 protein modified form] CTD PMID:11889176 NCBI chr 6:54,263,574...54,269,286 JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions
EXP Troglitazone results in increased phosphorylation of MAPK1 protein
Pioglitazone promotes the reaction [Troglitazone results in increased phosphorylation of MAPK1 protein]
CTD PMID:17065204 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
EXP Pioglitazone promotes the reaction [Troglitazone results in increased phosphorylation of MAPK3 protein] CTD PMID:17065204 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions
increases activity
EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Troglitazone results in increased activity of PPARG protein]; Troglitazone inhibits the reaction [Pioglitazone results in increased activity of PPARG protein]; Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of PPARG mRNA] CTD PMID:14506076, PMID:17065204, PMID:30481989 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,655...68,433,947
JBrowse link
G SCARB1 scavenger receptor class B member 1 affects localization EXP Troglitazone affects the localization of SCARB1 protein CTD PMID:16530456 NCBI chr14:28,301,421...28,393,568
Ensembl chr14:28,301,294...28,393,565
JBrowse link
G SPP1 secreted phosphoprotein 1 multiple interactions EXP Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of SPP1 mRNA] CTD PMID:30481989 NCBI chr 8:131,077,786...131,085,334
Ensembl chr 8:131,077,786...131,085,340
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP [Troglitazone co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein] CTD PMID:15226458 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
VX nerve agent term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase multiple interactions
decreases activity
EXP N,N'-monomethylenebis(pyridiniumaldoxime) inhibits the reaction [VX results in decreased activity of ACHE protein] CTD PMID:20888357 NCBI chr 3:8,732,451...8,738,274
Ensembl chr 3:8,732,324...8,739,149
JBrowse link
zileuton term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5 arachidonate 5-lipoxygenase decreases activity EXP zileuton results in decreased activity of ALOX5 protein CTD PMID:11509739 NCBI chr14:90,859,209...90,907,084
Ensembl chr14:90,858,975...90,907,094
JBrowse link
zinc sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP Zinc Sulfate results in increased expression of BAX mRNA
3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of BAX mRNA]
CTD PMID:28803810 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144
JBrowse link
G BECN1 beclin 1 increases expression
multiple interactions
EXP Zinc Sulfate results in increased expression of BECN1 protein
3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of BECN1 protein]
CTD PMID:28803810 NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373
JBrowse link
G CASP3 caspase 3 multiple interactions
increases expression
increases cleavage
EXP 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased cleavage of CASP3 protein]
Zinc Sulfate results in increased expression of CASP3 mRNA
CTD PMID:28803810 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CASP6 caspase 6 increases expression EXP Zinc Sulfate results in increased expression of CASP6 mRNA CTD PMID:28803810 NCBI chr 8:112,519,450...112,534,315
Ensembl chr 8:112,483,392...112,540,550
JBrowse link
G CASP8 caspase 8 multiple interactions
increases cleavage
EXP 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased cleavage of CASP8 protein] CTD PMID:28803810 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,470
JBrowse link
G CYCS cytochrome c, somatic increases expression
multiple interactions
EXP Zinc Sulfate results in increased expression of CYCS mRNA
3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of CYCS mRNA]
CTD PMID:28803810 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
JBrowse link
G HSPA6 heat shock protein family A (Hsp70) member 6 increases expression EXP Zinc Sulfate results in increased expression of HSP70 mRNA CTD PMID:23274768 NCBI chr 4:88,970,592...88,973,109
Ensembl chr 4:88,970,591...88,985,586
JBrowse link
G MAP1LC3A microtubule associated protein 1 light chain 3 alpha increases expression EXP Zinc Sulfate results in increased expression of MAP1LC3A mRNA CTD PMID:28803810 NCBI chr17:37,957,830...37,959,505
Ensembl chr17:37,957,507...37,959,505
JBrowse link
G MT1A metallothionein 1A increases expression EXP Zinc Sulfate results in increased expression of MT1A mRNA CTD PMID:25895165 NCBI chr 6:18,672,016...18,673,673
Ensembl chr 6:18,660,642...18,673,766
JBrowse link
G SLC30A1 solute carrier family 30 member 1 increases expression EXP Zinc Sulfate results in increased expression of SLC30A1 mRNA CTD PMID:25895165 NCBI chr 9:131,633,586...131,636,934
Ensembl chr 9:131,633,585...131,640,675
JBrowse link
G SLC39A10 solute carrier family 39 member 10 decreases expression
increases expression
EXP Zinc Sulfate results in decreased expression of SLC39A10 mRNA
Zinc Sulfate results in increased expression of SLC39A10 mRNA
CTD PMID:16804107 NCBI chr15:99,584,830...99,724,621
Ensembl chr15:99,584,839...99,726,404
JBrowse link
G SQSTM1 sequestosome 1 increases expression
multiple interactions
decreases expression
EXP Zinc Sulfate results in increased expression of SQSTM1 mRNA
3-methyladenine inhibits the reaction [Zinc Sulfate results in decreased expression of SQSTM1 protein]
CTD PMID:28803810 NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,768...78,784,256
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 860
    chemical entity 860
      atom 845
        nonmetal atom 823
          sulfur atom 210
            sulfur molecular entity + 210
            sulfur-32 atom 0
            sulfur-33 atom 0
            sulfur-34 atom 0
            sulfur-35 atom 0
            sulfur-36 atom 0
            sulfur-37 atom 0
            sulfur-38 atom 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 860
    subatomic particle 845
      composite particle 845
        hadron 845
          baryon 845
            nucleon 845
              atomic nucleus 845
                atom 845
                  main group element atom 834
                    p-block element atom 831
                      chalcogen 797
                        sulfur atom 210
                          sulfur molecular entity + 210
                          sulfur-32 atom 0
                          sulfur-33 atom 0
                          sulfur-34 atom 0
                          sulfur-35 atom 0
                          sulfur-36 atom 0
                          sulfur-37 atom 0
                          sulfur-38 atom 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.