|
G |
Adgre4 |
adhesion G protein-coupled receptor E4 |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of ADGRE4 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr 9:8,056,034...8,200,262
Ensembl chr 9:8,052,210...8,198,800
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|
G |
Adgre5 |
adhesion G protein-coupled receptor E5 |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of ADGRE5 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr19:24,854,981...24,875,712
Ensembl chr19:24,855,299...24,875,137
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|
G |
Afp |
alpha-fetoprotein |
multiple interactions decreases expression |
ISO |
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of AFP mRNA] S-Adenosylmethionine results in decreased expression of AFP mRNA |
CTD |
PMID:18098314 |
|
NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
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|
G |
Ahr |
aryl hydrocarbon receptor |
decreases abundance multiple interactions |
ISO |
AHR protein results in decreased abundance of S-Adenosylmethionine PEMT protein promotes the reaction [AHR protein results in decreased abundance of S-Adenosylmethionine] |
CTD |
PMID:29416063 |
|
NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
|
|
G |
Alad |
aminolevulinate dehydratase |
increases activity |
ISO |
S-Adenosylmethionine results in increased activity of ALAD protein |
CTD |
PMID:9559101 |
|
NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
|
|
G |
Alas2 |
5'-aminolevulinate synthase 2 |
multiple interactions |
ISO |
[S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA] |
CTD |
PMID:24141029 |
|
NCBI chr X:23,167,576...23,187,356
Ensembl chr X:23,167,696...23,187,341
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|
G |
App |
amyloid beta precursor protein |
increases secretion |
ISO |
S-Adenosylmethionine results in increased secretion of APP protein modified form |
CTD |
PMID:22906069 |
|
NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
|
|
G |
As3mt |
arsenite methyltransferase |
multiple interactions affects binding |
ISO |
Cysteine promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]; Glutathione promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]; S-Adenosylmethionine promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]; tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein binds to S-Adenosylmethionine] |
CTD |
PMID:22955273 PMID:25349987 |
|
NCBI chr 1:266,482,787...266,514,570
Ensembl chr 1:266,482,858...266,514,569
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|
G |
Atf3 |
activating transcription factor 3 |
increases expression |
ISO |
S-Adenosylmethionine results in increased expression of ATF3 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
|
|
G |
Atp7b |
ATPase copper transporting beta |
multiple interactions |
ISO |
ATP7B protein mutant form promotes the reaction [Betaine results in increased abundance of S-Adenosylmethionine] |
CTD |
PMID:22945834 |
|
NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
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|
G |
Bhmt2 |
betaine-homocysteine S-methyltransferase 2 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [BHMT2 protein results in increased metabolism of Vitamin U] |
CTD |
PMID:18230605 |
|
NCBI chr 2:23,272,320...23,289,266
Ensembl chr 2:23,272,328...23,289,266
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|
G |
Casp12 |
caspase 12 |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of CASP12 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
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|
G |
Casp3 |
caspase 3 |
multiple interactions decreases activity |
ISO EXP |
S-Adenosylmethionine inhibits the reaction [Ethanol results in increased activity of CASP3 protein] S-Adenosylmethionine results in decreased activity of CASP3 protein |
CTD |
PMID:17869084 PMID:18571630 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Cat |
catalase |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of CAT protein] |
CTD |
PMID:22683606 |
|
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
|
|
G |
Col1a1 |
collagen type I alpha 1 chain |
decreases expression multiple interactions |
ISO |
S-Adenosylmethionine results in decreased expression of COL1A1 mRNA S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA] |
CTD |
PMID:15983038 PMID:16996477 |
|
NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
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|
G |
Col1a2 |
collagen type I alpha 2 chain |
multiple interactions decreases expression |
ISO EXP |
S-Adenosylmethionine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA]; S-Adenosylmethionine inhibits the reaction [SP1 protein binds to COL1A2 promoter]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein binds to COL1A2 promoter] S-Adenosylmethionine results in decreased expression of COL1A2 mRNA |
CTD |
PMID:8878782 PMID:15983038 |
|
NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
|
|
G |
Comt |
catechol-O-methyltransferase |
multiple interactions |
ISO |
[tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of S-Adenosylmethionine] |
CTD |
PMID:16758261 |
|
NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
|
|
G |
Cycs |
cytochrome c, somatic |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Acetaminophen affects the localization of CYCS protein] |
CTD |
PMID:22683606 |
|
NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
|
|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
decreases activity multiple interactions |
ISO EXP |
S-Adenosylmethionine results in decreased activity of CYP2E1 protein S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of 4-nitrophenol]; S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of Dimethylnitrosamine]; S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of Ethanol] S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased expression of CYP2E1 protein]; S-Adenosylmethionine promotes the reaction [Carbon Tetrachloride results in decreased expression of and results in decreased activity of CYP2E1 protein] |
CTD |
PMID:15763544 PMID:15983038 PMID:22683606 |
|
NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
|
|
G |
Ddc |
dopa decarboxylase |
multiple interactions |
ISO |
[Levodopa co-treated with DDC] results in increased abundance of S-Adenosylmethionine |
CTD |
PMID:11445284 |
|
NCBI chr14:91,905,919...91,996,816
Ensembl chr14:91,905,919...91,996,774
|
|
G |
Dlg4 |
discs large MAGUK scaffold protein 4 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of DLG4 protein] |
CTD |
PMID:27624276 |
|
NCBI chr10:56,625,845...56,655,543
Ensembl chr10:56,627,411...56,653,599
|
|
G |
Dnmt1 |
DNA methyltransferase 1 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [arsenic trioxide inhibits the reaction [DNMT1 protein binds to ESR1 promoter]]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased expression of DNMT1 protein] |
CTD |
PMID:22558281 |
|
NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
|
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G |
Dnmt3a |
DNA methyltransferase 3 alpha |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased expression of DNMT3A protein] S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of DNMT3A mRNA] |
CTD |
PMID:18098314 PMID:22558281 |
|
NCBI chr 6:28,205,375...28,346,052
Ensembl chr 6:28,235,695...28,340,577
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]; S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide inhibits the reaction [DNMT1 protein binds to ESR1 promoter]]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased methylation of ESR1 promoter]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of ESR1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of ESR1 protein] |
CTD |
PMID:22558281 |
|
NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
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G |
Fcgr1a |
Fc fragment of IgG receptor Ia |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of FCGR1 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr 2:198,430,536...198,439,453
Ensembl chr 2:198,430,530...198,458,041
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|
G |
Fgf19 |
fibroblast growth factor 19 |
increases abundance |
ISO |
FGF19 protein results in increased abundance of S-Adenosylmethionine |
CTD |
PMID:29416063 |
|
NCBI chr 1:218,058,405...218,061,693
Ensembl chr 1:218,058,405...218,061,693
|
|
G |
Fgl2 |
fibrinogen-like 2 |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of FGL2 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr 4:10,323,598...10,329,241
Ensembl chr 4:10,323,607...10,329,241
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|
G |
Gbp2 |
guanylate binding protein 2 |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of GBP2 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr 2:248,276,795...248,293,784
Ensembl chr 2:248,276,709...248,293,784
|
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]] |
CTD |
PMID:20146260 |
|
NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
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G |
Greb1 |
growth regulating estrogen receptor binding 1 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of GREB1 mRNA] |
CTD |
PMID:22558281 |
|
NCBI chr 6:41,932,941...42,002,770
Ensembl chr 6:41,932,244...42,002,819
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of GSR protein] |
CTD |
PMID:22683606 |
|
NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
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G |
Gss |
glutathione synthetase |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]] |
CTD |
PMID:20146260 |
|
NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557
|
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G |
Gstm2 |
glutathione S-transferase mu 2 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of GSTM2 mRNA] |
CTD |
PMID:18098314 |
|
NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
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|
G |
Hand2 |
heart and neural crest derivatives expressed 2 |
multiple interactions |
ISO |
[Progesterone co-treated with S-Adenosylmethionine] results in increased methylation of HAND2 promoter; S-Adenosylmethionine inhibits the reaction [Progesterone results in increased expression of HAND2 mRNA] |
CTD |
PMID:30892605 |
|
NCBI chr16:36,371,489...36,373,551
Ensembl chr16:36,371,489...36,373,546
|
|
G |
Hbb |
hemoglobin subunit beta |
multiple interactions |
ISO |
[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA] |
CTD |
PMID:24141029 |
|
NCBI chr 1:168,971,269...168,972,680
Ensembl chr 1:168,971,274...168,972,725
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G |
Hdac9 |
histone deacetylase 9 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of HDAC9 mRNA] |
CTD |
PMID:18098314 |
|
NCBI chr 6:53,487,367...54,358,694
Ensembl chr 6:53,488,883...54,059,119
|
|
G |
Hmbs |
hydroxymethylbilane synthase |
multiple interactions |
ISO |
[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA] |
CTD |
PMID:24141029 |
|
NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
|
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G |
Ifi44l |
interferon-induced protein 44-like |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of IFI44L mRNA |
CTD |
PMID:18098314 |
|
NCBI chr 2:256,948,722...256,979,573
Ensembl chr 2:256,964,860...256,978,668
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|
G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IFNG mRNA] |
CTD |
PMID:17080400 |
|
NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP ISO |
S-Adenosylmethionine inhibits the reaction [Thioacetamide results in increased expression of IL1B protein] S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IL1B mRNA] |
CTD |
PMID:17080400 PMID:19822164 |
|
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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G |
Il2 |
interleukin 2 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IL2 mRNA] |
CTD |
PMID:17080400 |
|
NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
|
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G |
Il2rg |
interleukin 2 receptor subunit gamma |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of IL2RG mRNA |
CTD |
PMID:18098314 |
|
NCBI chr X:71,165,378...71,169,078
Ensembl chr X:71,162,585...71,169,865
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G |
Il6 |
interleukin 6 |
multiple interactions |
EXP ISO |
S-Adenosylmethionine inhibits the reaction [Thioacetamide results in increased expression of IL6 protein] S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IL6 mRNA] |
CTD |
PMID:17080400 PMID:19822164 |
|
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
|
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G |
Klf6 |
Kruppel-like factor 6 |
decreases expression multiple interactions |
ISO |
S-Adenosylmethionine results in decreased expression of KLF6 mRNA S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of KLF6 mRNA] |
CTD |
PMID:18098314 |
|
NCBI chr17:67,887,939...67,945,052
Ensembl chr17:67,887,939...67,945,037
|
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G |
Lep |
leptin |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA]; S-Adenosylmethionine inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA] |
CTD |
PMID:16996477 |
|
NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
|
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G |
LOC103694381 |
lymphotoxin-beta |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of LTB mRNA] |
CTD |
PMID:17080400 |
|
NCBI chr20:4,861,343...4,863,513
Ensembl chr20:4,861,335...4,863,198
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|
G |
Maf |
MAF bZIP transcription factor |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]] |
CTD |
PMID:20146260 |
|
NCBI chr19:48,179,826...48,200,995
Ensembl chr19:48,194,804...48,196,748
|
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G |
Mafg |
MAF bZIP transcription factor G |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]] |
CTD |
PMID:20146260 |
|
NCBI chr10:109,802,877...109,811,476
Ensembl chr10:109,806,159...109,811,323
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein] [1,2-linoleoylphosphatidylcholine co-treated with S-Adenosylmethionine] inhibits the reaction [Vitamin K 3 results in increased phosphorylation of MAPK1 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]] |
CTD |
PMID:15983038 PMID:16996477 |
|
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
|
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein] [1,2-linoleoylphosphatidylcholine co-treated with S-Adenosylmethionine] inhibits the reaction [Vitamin K 3 results in increased phosphorylation of MAPK3 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]] |
CTD |
PMID:15983038 PMID:16996477 |
|
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
|
|
G |
Mat1a |
methionine adenosyltransferase 1A |
affects abundance increases chemical synthesis |
ISO |
MAT1A affects the abundance of S-Adenosylmethionine MAT1A protein results in increased chemical synthesis of S-Adenosylmethionine |
CTD |
PMID:8373829 PMID:12060674 |
|
NCBI chr16:18,690,649...18,709,135
Ensembl chr16:18,690,246...18,709,133
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G |
Mat2a |
methionine adenosyltransferase 2A |
increases chemical synthesis |
ISO |
MAT2A protein results in increased chemical synthesis of S-Adenosylmethionine |
CTD |
PMID:8373829 |
|
NCBI chr 4:100,297,478...100,303,047
Ensembl chr 4:100,296,075...100,303,080
|
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G |
Mbd2 |
methyl-CpG binding domain protein 2 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of MBD2 protein] |
CTD |
PMID:22558281 |
|
NCBI chr18:65,814,026...65,885,115
Ensembl chr18:65,814,026...65,885,114
|
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G |
Mthfd1 |
methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 |
increases abundance |
ISO |
MTHFD1 protein results in increased abundance of S-Adenosylmethionine |
CTD |
PMID:19033438 |
|
NCBI chr 6:99,282,850...99,350,367
Ensembl chr 6:99,282,850...99,350,340
|
|
G |
Mtr |
5-methyltetrahydrofolate-homocysteine methyltransferase |
affects binding multiple interactions |
ISO |
S-Adenosylmethionine binds to MTR protein [glutathionylcobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form; [Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form; Aluminum inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Arsenic inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Glutathione inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione inhibits the reaction [Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione promotes the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Lead inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; mecobalamin inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Mercury inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form] |
CTD |
PMID:17477549 PMID:26989453 |
|
NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014
|
|
G |
Ndrg1 |
N-myc downstream regulated 1 |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of NDRG1 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr 7:107,734,326...107,775,701
Ensembl chr 7:107,734,323...107,775,714
|
|
G |
Nfe2l2 |
nuclear factor, erythroid 2-like 2 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]] |
CTD |
PMID:20146260 |
|
NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
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|
G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
EXP |
S-Adenosylmethionine inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:18404532 |
|
NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
|
|
G |
Nlgn3 |
neuroligin 3 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NLGN3 mRNA]; S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in increased methylation of NLGN3 promoter]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NLGN3 mRNA]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NLGN3 protein]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in increased methylation of NLGN3 promoter] |
CTD |
PMID:27624276 |
|
NCBI chr X:71,199,390...71,227,460
Ensembl chr X:71,199,491...71,222,732
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G |
Nr0b2 |
nuclear receptor subfamily 0, group B, member 2 |
increases abundance |
ISO |
NR0B2 protein results in increased abundance of S-Adenosylmethionine |
CTD |
PMID:29416063 |
|
NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
|
|
G |
Nrxn1 |
neurexin 1 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NRXN1 mRNA]; S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in increased methylation of NRXN1 promoter]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NRXN1 mRNA]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NRXN1 protein]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in increased methylation of NRXN1 promoter] |
CTD |
PMID:27624276 |
|
NCBI chr 6:13,886,757...15,191,660
Ensembl chr 6:13,886,740...15,191,660
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|
G |
Pde4b |
phosphodiesterase 4B |
multiple interactions |
ISO |
[[S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; [S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP; S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA] |
CTD |
PMID:21266552 |
|
NCBI chr 5:121,759,236...122,136,814
Ensembl chr 5:121,952,977...122,136,814
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|
G |
Pemt |
phosphatidylethanolamine N-methyltransferase |
multiple interactions |
ISO |
PEMT protein promotes the reaction [AHR protein results in decreased abundance of S-Adenosylmethionine] |
CTD |
PMID:29416063 |
|
NCBI chr10:46,339,821...46,404,640
Ensembl chr10:46,339,821...46,404,642
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G |
Pfn2 |
profilin 2 |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of PFN2 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr 2:147,953,858...147,959,692
Ensembl chr 2:147,955,196...148,050,438
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|
G |
Psmb8 |
proteasome 20S subunit beta 8 |
increases expression |
ISO |
S-Adenosylmethionine results in increased expression of PSMB8 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr20:3,990,809...3,993,772
Ensembl chr20:3,990,613...3,993,769
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G |
Ptgs1 |
prostaglandin-endoperoxide synthase 1 |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of PTGS1 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein] |
CTD |
PMID:21266552 |
|
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Rnasel |
ribonuclease L |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of RNASEL mRNA |
CTD |
PMID:18098314 |
|
NCBI chr13:71,188,712...71,202,636
Ensembl chr13:71,192,142...71,202,625
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G |
RT1-Db1 |
RT1 class II, locus Db1 |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of H2-EB1 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190
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G |
Slc19a1 |
solute carrier family 19 member 1 |
affects abundance |
ISO |
SLC19A1 protein affects the abundance of S-Adenosylmethionine |
CTD |
PMID:15705887 |
|
NCBI chr20:12,334,675...12,354,517
Ensembl chr20:12,334,676...12,352,377
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G |
Smyd2 |
SET and MYND domain containing 2 |
affects binding |
ISO |
S-Adenosylmethionine binds to SMYD2 protein |
CTD |
PMID:21782458 |
|
NCBI chr13:108,642,156...108,686,293
Ensembl chr13:108,642,156...108,686,290
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|
G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of SOD1 protein] |
CTD |
PMID:22683606 |
|
NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of SOD2 protein] |
CTD |
PMID:22683606 |
|
NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
|
|
G |
Sp1 |
Sp1 transcription factor |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]] S-Adenosylmethionine inhibits the reaction [SP1 protein binds to COL1A2 promoter] |
CTD |
PMID:15983038 |
|
NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
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G |
Syn1 |
synapsin I |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of SYN1 protein] |
CTD |
PMID:27624276 |
|
NCBI chr X:1,321,315...1,379,202
Ensembl chr X:1,321,315...1,379,198
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G |
Tf |
transferrin |
multiple interactions increases expression |
EXP |
[S-Adenosylmethionine results in increased expression of TF protein] which affects the abundance of Iron |
CTD |
PMID:18571630 |
|
NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
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G |
Tff1 |
trefoil factor 1 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of TFF1 mRNA] |
CTD |
PMID:22558281 |
|
NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
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G |
Tfrc |
transferrin receptor |
decreases expression |
EXP |
S-Adenosylmethionine results in decreased expression of TFRC mRNA |
CTD |
PMID:18571630 |
|
NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]] S-Adenosylmethionine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein binds to COL1A2 promoter]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:15983038 |
|
NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO EXP |
[[S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] S-Adenosylmethionine inhibits the reaction [Thioacetamide results in increased expression of TNF protein] |
CTD |
PMID:19822164 PMID:21266552 |
|
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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G |
Tpmt |
thiopurine S-methyltransferase |
multiple interactions |
ISO |
[S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-methylbenzenethiol; [S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol; [S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-methylbenzenethiol; [S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol; S-Adenosylmethionine analog inhibits the reaction [[S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol]; S-Adenosylmethionine inhibits the reaction [[S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol] |
CTD |
PMID:20196537 |
|
NCBI chr17:18,029,090...18,047,716
Ensembl chr17:18,029,124...18,047,714
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G |
Ubd |
ubiquitin D |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of UBD mRNA] |
CTD |
PMID:18098314 |
|
NCBI chr20:1,876,175...1,878,126
Ensembl chr20:1,876,173...1,897,814
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G |
Vim |
vimentin |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [monobutyl phthalate results in increased expression of VIM mRNA]; S-Adenosylmethionine inhibits the reaction [monobutyl phthalate results in increased expression of VIM protein] |
CTD |
PMID:26745512 |
|
NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
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|
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G |
Adgre4 |
adhesion G protein-coupled receptor E4 |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of ADGRE4 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr 9:8,056,034...8,200,262
Ensembl chr 9:8,052,210...8,198,800
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G |
Adgre5 |
adhesion G protein-coupled receptor E5 |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of ADGRE5 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr19:24,854,981...24,875,712
Ensembl chr19:24,855,299...24,875,137
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G |
Afp |
alpha-fetoprotein |
multiple interactions decreases expression |
ISO |
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of AFP mRNA] S-Adenosylmethionine results in decreased expression of AFP mRNA |
CTD |
PMID:18098314 |
|
NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions decreases abundance |
ISO |
PEMT protein promotes the reaction [AHR protein results in decreased abundance of S-Adenosylmethionine] |
CTD |
PMID:29416063 |
|
NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
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G |
Alad |
aminolevulinate dehydratase |
increases activity |
ISO |
S-Adenosylmethionine results in increased activity of ALAD protein |
CTD |
PMID:9559101 |
|
NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
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G |
Alas2 |
5'-aminolevulinate synthase 2 |
multiple interactions |
ISO |
[S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA] |
CTD |
PMID:24141029 |
|
NCBI chr X:23,167,576...23,187,356
Ensembl chr X:23,167,696...23,187,341
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G |
App |
amyloid beta precursor protein |
increases secretion |
ISO |
S-Adenosylmethionine results in increased secretion of APP protein modified form |
CTD |
PMID:22906069 |
|
NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
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G |
As3mt |
arsenite methyltransferase |
multiple interactions affects binding |
ISO |
Cysteine promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]; Glutathione promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]; S-Adenosylmethionine promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]; tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein binds to S-Adenosylmethionine] |
CTD |
PMID:22955273 PMID:25349987 |
|
NCBI chr 1:266,482,787...266,514,570
Ensembl chr 1:266,482,858...266,514,569
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G |
Atf3 |
activating transcription factor 3 |
increases expression |
ISO |
S-Adenosylmethionine results in increased expression of ATF3 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
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G |
Atp7b |
ATPase copper transporting beta |
multiple interactions |
ISO |
ATP7B protein mutant form promotes the reaction [Betaine results in increased abundance of S-Adenosylmethionine] |
CTD |
PMID:22945834 |
|
NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
|
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G |
Bhmt2 |
betaine-homocysteine S-methyltransferase 2 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [BHMT2 protein results in increased metabolism of Vitamin U] |
CTD |
PMID:18230605 |
|
NCBI chr 2:23,272,320...23,289,266
Ensembl chr 2:23,272,328...23,289,266
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G |
Casp12 |
caspase 12 |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of CASP12 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
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G |
Casp3 |
caspase 3 |
multiple interactions decreases activity |
ISO EXP |
S-Adenosylmethionine inhibits the reaction [Ethanol results in increased activity of CASP3 protein] S-Adenosylmethionine results in decreased activity of CASP3 protein |
CTD |
PMID:17869084 PMID:18571630 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Cat |
catalase |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of CAT protein] |
CTD |
PMID:22683606 |
|
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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G |
Col1a1 |
collagen type I alpha 1 chain |
decreases expression multiple interactions |
ISO |
S-Adenosylmethionine results in decreased expression of COL1A1 mRNA S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA] |
CTD |
PMID:15983038 PMID:16996477 |
|
NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
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G |
Col1a2 |
collagen type I alpha 2 chain |
decreases expression multiple interactions |
ISO EXP |
S-Adenosylmethionine results in decreased expression of COL1A2 mRNA S-Adenosylmethionine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA] S-Adenosylmethionine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA]; S-Adenosylmethionine inhibits the reaction [SP1 protein binds to COL1A2 promoter]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein binds to COL1A2 promoter] |
CTD |
PMID:8878782 PMID:15983038 |
|
NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
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G |
Comt |
catechol-O-methyltransferase |
multiple interactions |
ISO |
[tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of S-Adenosylmethionine] |
CTD |
PMID:16758261 |
|
NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
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G |
Cycs |
cytochrome c, somatic |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Acetaminophen affects the localization of CYCS protein] |
CTD |
PMID:22683606 |
|
NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
|
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
decreases activity multiple interactions |
ISO EXP |
S-Adenosylmethionine results in decreased activity of CYP2E1 protein S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of 4-nitrophenol]; S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of Dimethylnitrosamine]; S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of Ethanol] S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased expression of CYP2E1 protein]; S-Adenosylmethionine promotes the reaction [Carbon Tetrachloride results in decreased expression of and results in decreased activity of CYP2E1 protein] |
CTD |
PMID:15763544 PMID:15983038 PMID:22683606 |
|
NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
|
|
G |
Ddc |
dopa decarboxylase |
multiple interactions |
ISO |
[Levodopa co-treated with DDC] results in increased abundance of S-Adenosylmethionine |
CTD |
PMID:11445284 |
|
NCBI chr14:91,905,919...91,996,816
Ensembl chr14:91,905,919...91,996,774
|
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G |
Dlg4 |
discs large MAGUK scaffold protein 4 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of DLG4 protein] |
CTD |
PMID:27624276 |
|
NCBI chr10:56,625,845...56,655,543
Ensembl chr10:56,627,411...56,653,599
|
|
G |
Dnmt1 |
DNA methyltransferase 1 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [arsenic trioxide inhibits the reaction [DNMT1 protein binds to ESR1 promoter]]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased expression of DNMT1 protein] |
CTD |
PMID:22558281 |
|
NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
|
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G |
Dnmt3a |
DNA methyltransferase 3 alpha |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of DNMT3A mRNA] S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased expression of DNMT3A protein] |
CTD |
PMID:18098314 PMID:22558281 |
|
NCBI chr 6:28,205,375...28,346,052
Ensembl chr 6:28,235,695...28,340,577
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]; S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide inhibits the reaction [DNMT1 protein binds to ESR1 promoter]]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased methylation of ESR1 promoter]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of ESR1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of ESR1 protein] |
CTD |
PMID:22558281 |
|
NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
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G |
Fcgr1a |
Fc fragment of IgG receptor Ia |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of FCGR1 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr 2:198,430,536...198,439,453
Ensembl chr 2:198,430,530...198,458,041
|
|
G |
Fgf19 |
fibroblast growth factor 19 |
increases abundance |
ISO |
FGF19 protein results in increased abundance of S-Adenosylmethionine |
CTD |
PMID:29416063 |
|
NCBI chr 1:218,058,405...218,061,693
Ensembl chr 1:218,058,405...218,061,693
|
|
G |
Fgl2 |
fibrinogen-like 2 |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of FGL2 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr 4:10,323,598...10,329,241
Ensembl chr 4:10,323,607...10,329,241
|
|
G |
Gbp2 |
guanylate binding protein 2 |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of GBP2 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr 2:248,276,795...248,293,784
Ensembl chr 2:248,276,709...248,293,784
|
|
G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]] |
CTD |
PMID:20146260 |
|
NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
|
|
G |
Greb1 |
growth regulating estrogen receptor binding 1 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of GREB1 mRNA] |
CTD |
PMID:22558281 |
|
NCBI chr 6:41,932,941...42,002,770
Ensembl chr 6:41,932,244...42,002,819
|
|
G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of GSR protein] |
CTD |
PMID:22683606 |
|
NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
|
|
G |
Gss |
glutathione synthetase |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]] |
CTD |
PMID:20146260 |
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NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557
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G |
Gstm2 |
glutathione S-transferase mu 2 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of GSTM2 mRNA] |
CTD |
PMID:18098314 |
|
NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
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G |
Hand2 |
heart and neural crest derivatives expressed 2 |
multiple interactions |
ISO |
[Progesterone co-treated with S-Adenosylmethionine] results in increased methylation of HAND2 promoter; S-Adenosylmethionine inhibits the reaction [Progesterone results in increased expression of HAND2 mRNA] |
CTD |
PMID:30892605 |
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NCBI chr16:36,371,489...36,373,551
Ensembl chr16:36,371,489...36,373,546
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G |
Hbb |
hemoglobin subunit beta |
multiple interactions |
ISO |
[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA] |
CTD |
PMID:24141029 |
|
NCBI chr 1:168,971,269...168,972,680
Ensembl chr 1:168,971,274...168,972,725
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G |
Hdac9 |
histone deacetylase 9 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of HDAC9 mRNA] |
CTD |
PMID:18098314 |
|
NCBI chr 6:53,487,367...54,358,694
Ensembl chr 6:53,488,883...54,059,119
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G |
Hmbs |
hydroxymethylbilane synthase |
multiple interactions |
ISO |
[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA] |
CTD |
PMID:24141029 |
|
NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
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G |
Ifi44l |
interferon-induced protein 44-like |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of IFI44L mRNA |
CTD |
PMID:18098314 |
|
NCBI chr 2:256,948,722...256,979,573
Ensembl chr 2:256,964,860...256,978,668
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IFNG mRNA] |
CTD |
PMID:17080400 |
|
NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP ISO |
S-Adenosylmethionine inhibits the reaction [Thioacetamide results in increased expression of IL1B protein] S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IL1B mRNA] |
CTD |
PMID:17080400 PMID:19822164 |
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NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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G |
Il2 |
interleukin 2 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IL2 mRNA] |
CTD |
PMID:17080400 |
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NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
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G |
Il2rg |
interleukin 2 receptor subunit gamma |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of IL2RG mRNA |
CTD |
PMID:18098314 |
|
NCBI chr X:71,165,378...71,169,078
Ensembl chr X:71,162,585...71,169,865
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G |
Il6 |
interleukin 6 |
multiple interactions |
EXP ISO |
S-Adenosylmethionine inhibits the reaction [Thioacetamide results in increased expression of IL6 protein] S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IL6 mRNA] |
CTD |
PMID:17080400 PMID:19822164 |
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NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Klf6 |
Kruppel-like factor 6 |
multiple interactions decreases expression |
ISO |
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of KLF6 mRNA] S-Adenosylmethionine results in decreased expression of KLF6 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr17:67,887,939...67,945,052
Ensembl chr17:67,887,939...67,945,037
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G |
Lep |
leptin |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA]; S-Adenosylmethionine inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA] |
CTD |
PMID:16996477 |
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NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
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G |
LOC103694381 |
lymphotoxin-beta |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of LTB mRNA] |
CTD |
PMID:17080400 |
|
NCBI chr20:4,861,343...4,863,513
Ensembl chr20:4,861,335...4,863,198
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G |
Maf |
MAF bZIP transcription factor |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]] |
CTD |
PMID:20146260 |
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NCBI chr19:48,179,826...48,200,995
Ensembl chr19:48,194,804...48,196,748
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G |
Mafg |
MAF bZIP transcription factor G |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]] |
CTD |
PMID:20146260 |
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NCBI chr10:109,802,877...109,811,476
Ensembl chr10:109,806,159...109,811,323
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein] [1,2-linoleoylphosphatidylcholine co-treated with S-Adenosylmethionine] inhibits the reaction [Vitamin K 3 results in increased phosphorylation of MAPK1 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]] |
CTD |
PMID:15983038 PMID:16996477 |
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NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
[1,2-linoleoylphosphatidylcholine co-treated with S-Adenosylmethionine] inhibits the reaction [Vitamin K 3 results in increased phosphorylation of MAPK3 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]] S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:15983038 PMID:16996477 |
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NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Mat1a |
methionine adenosyltransferase 1A |
affects abundance increases chemical synthesis |
ISO |
MAT1A affects the abundance of S-Adenosylmethionine MAT1A protein results in increased chemical synthesis of S-Adenosylmethionine |
CTD |
PMID:8373829 PMID:12060674 |
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NCBI chr16:18,690,649...18,709,135
Ensembl chr16:18,690,246...18,709,133
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G |
Mat2a |
methionine adenosyltransferase 2A |
increases chemical synthesis |
ISO |
MAT2A protein results in increased chemical synthesis of S-Adenosylmethionine |
CTD |
PMID:8373829 |
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NCBI chr 4:100,297,478...100,303,047
Ensembl chr 4:100,296,075...100,303,080
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G |
Mbd2 |
methyl-CpG binding domain protein 2 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of MBD2 protein] |
CTD |
PMID:22558281 |
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NCBI chr18:65,814,026...65,885,115
Ensembl chr18:65,814,026...65,885,114
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G |
Mthfd1 |
methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 |
increases abundance |
ISO |
MTHFD1 protein results in increased abundance of S-Adenosylmethionine |
CTD |
PMID:19033438 |
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NCBI chr 6:99,282,850...99,350,367
Ensembl chr 6:99,282,850...99,350,340
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G |
Mtr |
5-methyltetrahydrofolate-homocysteine methyltransferase |
affects binding multiple interactions |
ISO |
S-Adenosylmethionine binds to MTR protein [glutathionylcobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form; [Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form; Aluminum inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Arsenic inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Glutathione inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione inhibits the reaction [Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione promotes the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Lead inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; mecobalamin inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Mercury inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form] |
CTD |
PMID:17477549 PMID:26989453 |
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NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014
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G |
Ndrg1 |
N-myc downstream regulated 1 |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of NDRG1 mRNA |
CTD |
PMID:18098314 |
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NCBI chr 7:107,734,326...107,775,701
Ensembl chr 7:107,734,323...107,775,714
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G |
Nfe2l2 |
nuclear factor, erythroid 2-like 2 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]] |
CTD |
PMID:20146260 |
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NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
EXP |
S-Adenosylmethionine inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:18404532 |
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NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
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G |
Nlgn3 |
neuroligin 3 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NLGN3 mRNA]; S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in increased methylation of NLGN3 promoter]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NLGN3 mRNA]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NLGN3 protein]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in increased methylation of NLGN3 promoter] |
CTD |
PMID:27624276 |
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NCBI chr X:71,199,390...71,227,460
Ensembl chr X:71,199,491...71,222,732
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G |
Nr0b2 |
nuclear receptor subfamily 0, group B, member 2 |
increases abundance |
ISO |
NR0B2 protein results in increased abundance of S-Adenosylmethionine |
CTD |
PMID:29416063 |
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NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
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G |
Nrxn1 |
neurexin 1 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NRXN1 mRNA]; S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in increased methylation of NRXN1 promoter]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NRXN1 mRNA]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NRXN1 protein]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in increased methylation of NRXN1 promoter] |
CTD |
PMID:27624276 |
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NCBI chr 6:13,886,757...15,191,660
Ensembl chr 6:13,886,740...15,191,660
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G |
Pde4b |
phosphodiesterase 4B |
multiple interactions |
ISO |
[[S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; [S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP; S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA] |
CTD |
PMID:21266552 |
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NCBI chr 5:121,759,236...122,136,814
Ensembl chr 5:121,952,977...122,136,814
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G |
Pemt |
phosphatidylethanolamine N-methyltransferase |
multiple interactions |
ISO |
PEMT protein promotes the reaction [AHR protein results in decreased abundance of S-Adenosylmethionine] |
CTD |
PMID:29416063 |
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NCBI chr10:46,339,821...46,404,640
Ensembl chr10:46,339,821...46,404,642
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G |
Pfn2 |
profilin 2 |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of PFN2 mRNA |
CTD |
PMID:18098314 |
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NCBI chr 2:147,953,858...147,959,692
Ensembl chr 2:147,955,196...148,050,438
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G |
Psmb8 |
proteasome 20S subunit beta 8 |
increases expression |
ISO |
S-Adenosylmethionine results in increased expression of PSMB8 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr20:3,990,809...3,993,772
Ensembl chr20:3,990,613...3,993,769
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G |
Ptgs1 |
prostaglandin-endoperoxide synthase 1 |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of PTGS1 mRNA |
CTD |
PMID:18098314 |
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NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein] |
CTD |
PMID:21266552 |
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NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Rnasel |
ribonuclease L |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of RNASEL mRNA |
CTD |
PMID:18098314 |
|
NCBI chr13:71,188,712...71,202,636
Ensembl chr13:71,192,142...71,202,625
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G |
RT1-Db1 |
RT1 class II, locus Db1 |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of H2-EB1 mRNA |
CTD |
PMID:18098314 |
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NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190
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G |
Slc19a1 |
solute carrier family 19 member 1 |
affects abundance |
ISO |
SLC19A1 protein affects the abundance of S-Adenosylmethionine |
CTD |
PMID:15705887 |
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NCBI chr20:12,334,675...12,354,517
Ensembl chr20:12,334,676...12,352,377
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G |
Smyd2 |
SET and MYND domain containing 2 |
affects binding |
ISO |
S-Adenosylmethionine binds to SMYD2 protein |
CTD |
PMID:21782458 |
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NCBI chr13:108,642,156...108,686,293
Ensembl chr13:108,642,156...108,686,290
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of SOD1 protein] |
CTD |
PMID:22683606 |
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NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of SOD2 protein] |
CTD |
PMID:22683606 |
|
NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
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G |
Sp1 |
Sp1 transcription factor |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]] S-Adenosylmethionine inhibits the reaction [SP1 protein binds to COL1A2 promoter] |
CTD |
PMID:15983038 |
|
NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
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G |
Syn1 |
synapsin I |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of SYN1 protein] |
CTD |
PMID:27624276 |
|
NCBI chr X:1,321,315...1,379,202
Ensembl chr X:1,321,315...1,379,198
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G |
Tf |
transferrin |
multiple interactions increases expression |
EXP |
[S-Adenosylmethionine results in increased expression of TF protein] which affects the abundance of Iron |
CTD |
PMID:18571630 |
|
NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
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G |
Tff1 |
trefoil factor 1 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of TFF1 mRNA] |
CTD |
PMID:22558281 |
|
NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
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G |
Tfrc |
transferrin receptor |
decreases expression |
EXP |
S-Adenosylmethionine results in decreased expression of TFRC mRNA |
CTD |
PMID:18571630 |
|
NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]] S-Adenosylmethionine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein binds to COL1A2 promoter]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:15983038 |
|
NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO EXP |
[[S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] S-Adenosylmethionine inhibits the reaction [Thioacetamide results in increased expression of TNF protein] |
CTD |
PMID:19822164 PMID:21266552 |
|
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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G |
Tpmt |
thiopurine S-methyltransferase |
multiple interactions |
ISO |
[S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-methylbenzenethiol; [S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol; [S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-methylbenzenethiol; [S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol; S-Adenosylmethionine analog inhibits the reaction [[S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol]; S-Adenosylmethionine inhibits the reaction [[S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol] |
CTD |
PMID:20196537 |
|
NCBI chr17:18,029,090...18,047,716
Ensembl chr17:18,029,124...18,047,714
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G |
Ubd |
ubiquitin D |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of UBD mRNA] |
CTD |
PMID:18098314 |
|
NCBI chr20:1,876,175...1,878,126
Ensembl chr20:1,876,173...1,897,814
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G |
Vim |
vimentin |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [monobutyl phthalate results in increased expression of VIM mRNA]; S-Adenosylmethionine inhibits the reaction [monobutyl phthalate results in increased expression of VIM protein] |
CTD |
PMID:26745512 |
|
NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
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G |
Spn |
sialophorin |
decreases response to substance |
ISO |
SPN protein results in decreased susceptibility to Trimethaphan |
CTD |
PMID:18711009 |
|
NCBI chr 1:198,572,999...198,585,664
Ensembl chr 1:198,572,999...198,577,226
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