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ONTOLOGY REPORT - ANNOTATIONS


Term:amphotericin B
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Accession:CHEBI:2682 term browser browse the term
Definition:A macrolide antibiotic used to treat potentially life-threatening fungal infections.
Synonyms:exact_synonym: (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-amino-3,6-dideoxy-beta-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
 related_synonym: AMPH-B;   Amphotericine B;   Formula=C47H73NO17;   InChI=1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1;   InChIKey=APKFDSVGJQXUKY-INPOYWNPSA-N;   Liposomal Amphotericin B;   SMILES=[H][C@]12C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\\C=C\\C=C\\C=C\\C=C\\C=C\\C=C\\C=C\\[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]1C(O)=O)O2;   amfotericina B;   amphotericinum B
 alt_id: CHEBI:106303;   CHEBI:566395
 xref: Beilstein:4645978 "Beilstein";   CAS:1397-89-3 "ChemIDplus";   CAS:1397-89-3 "DrugBank";   CAS:1397-89-3 "KEGG COMPOUND";   CAS:1397-89-3 "KEGG DRUG";   DrugBank:DB00681;   Drug_Central:197 "DrugCentral";   KEGG:C06573;   KEGG:D00203;   LIPID_MAPS_instance:LMPK06000002 "LIPID MAPS"
 xref_mesh: MESH:D000666
 xref: PMID:11429202 "Europe PMC";   PMID:16120633 "Europe PMC";   PMID:16793999 "Europe PMC";   PMID:1732516 "ChEMBL";   PMID:17507115 "ChEMBL";   Patent:US2908611;   Reaxys:4645978 "Reaxys";   Wikipedia:Amphotericin_B


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amphotericin B term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arhgef26 Rho guanine nucleotide exchange factor 26 JBrowse link 2 27,107,263 27,236,336 RGD:6480464
G Arnt aryl hydrocarbon receptor nuclear translocator JBrowse link 2 196,594,178 196,651,486 RGD:6480464
G Atg3 autophagy related 3 JBrowse link 11 60,585,192 60,613,706 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Ccr2 C-C motif chemokine receptor 2 RGD:6480464
G Clu clusterin JBrowse link 15 42,626,612 42,665,858 RGD:6480464
G Ednrb endothelin receptor type B JBrowse link 15 88,004,775 88,036,354 RGD:6480464
G Eno1 enolase 1 JBrowse link 5 167,288,223 167,299,610 RGD:6480464
G Ep300 E1A binding protein p300 JBrowse link 7 122,818,194 122,889,055 RGD:6480464
G Epo erythropoietin JBrowse link 12 22,274,828 22,278,268 RGD:6480464
G Glod4 glyoxalase domain containing 4 JBrowse link 10 64,379,922 64,398,263 RGD:6480464
G Gpr20 G protein-coupled receptor 20 JBrowse link 7 114,943,675 114,953,977 RGD:6480464
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:6480464
G Gstt1 glutathione S-transferase theta 1 JBrowse link 20 13,799,102 13,816,527 RGD:6480464
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:6480464
G Hif1an hypoxia inducible factor 1 subunit alpha inhibitor JBrowse link 1 264,309,214 264,319,269 RGD:6480464
G Hspa8 heat shock protein family A (Hsp70) member 8 JBrowse link 8 44,989,401 44,993,261 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Ifngr1 interferon gamma receptor 1 JBrowse link 1 15,062,380 15,080,815 RGD:6480464
G Igfbp5 insulin-like growth factor binding protein 5 JBrowse link 9 80,154,230 80,166,813 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6480464
G Kcnq4 potassium voltage-gated channel subfamily Q member 4 JBrowse link 5 139,625,783 139,677,300 RGD:6480464
G Lsg1 large 60S subunit nuclear export GTPase 1 JBrowse link 11 73,693,862 73,723,457 RGD:6480464
G Map1lc3b microtubule-associated protein 1 light chain 3 beta JBrowse link 19 53,635,449 53,643,970 RGD:6480464
G Nprl2 NPR2-like, GATOR1 complex subunit JBrowse link 8 116,297,950 116,301,123 RGD:6480464
G Nt5c2 5'-nucleotidase, cytosolic II JBrowse link 1 266,652,966 266,782,935 RGD:6480464
G Paip1 poly(A) binding protein interacting protein 1 JBrowse link 2 52,300,921 52,328,212 RGD:6480464
G Pard3 par-3 family cell polarity regulator JBrowse link 19 60,017,746 60,580,628 RGD:6480464
G Pgk1 phosphoglycerate kinase 1 JBrowse link X 77,263,399 77,279,373 RGD:6480464
G Polm DNA polymerase mu JBrowse link 14 86,069,378 86,079,327 RGD:6480464
G RT1-CE5 RT1 class I, locus CE5 JBrowse link 20 4,892,702 4,896,993 RGD:6480464
G Runx3 RUNX family transcription factor 3 JBrowse link 5 153,507,093 153,531,137 RGD:6480464
G Slit1 slit guidance ligand 1 JBrowse link 1 260,843,481 260,992,366 RGD:6480464
G Spp1 secreted phosphoprotein 1 JBrowse link 14 6,673,686 6,679,965 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 JBrowse link 9 95,161,157 95,302,822 RGD:6480464
G Usp36 ubiquitin specific peptidase 36 JBrowse link 10 107,292,828 107,324,355 RGD:6480464
amphotericin B methyl ester term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Havcr1 hepatitis A virus cellular receptor 1 JBrowse link 10 31,813,819 31,860,934 RGD:6480464
G Lcn2 lipocalin 2 JBrowse link 3 11,414,189 11,417,534 RGD:6480464
G Spp1 secreted phosphoprotein 1 JBrowse link 14 6,673,686 6,679,965 RGD:6480464
G Timp1 TIMP metallopeptidase inhibitor 1 JBrowse link X 1,364,771 1,369,451 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        antimicrobial agent 17151
          macrolide antibiotic 323
            amphotericin B 44
              amphotericin B methyl ester 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic ester 13934
                                        lactone 5859
                                          macrocyclic lactone 1515
                                            macrolide 1454
                                              macrolide antibiotic 323
                                                amphotericin B 44
                                                  amphotericin B methyl ester 4
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.