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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:steroid alkaloid
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Accession:CHEBI:26767 term browser browse the term
Synonyms:related_synonym: steroidal alkaloids


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solasodine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO solasodine results in decreased phosphorylation of AKT1 protein CTD PMID:28283413 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bche butyrylcholinesterase decreases activity ISO solasodine results in decreased activity of BCHE protein CTD PMID:31152736 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Bsg basigin decreases expression ISO solasodine results in decreased expression of BSG mRNA CTD PMID:28283413 NCBI chr 7:9,993,170...10,000,387
Ensembl chr 7:9,993,170...10,000,387 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO solasodine results in increased cleavage of and results in decreased expression of CASP3 protein CTD PMID:37121296 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO solasodine results in increased cleavage of and results in decreased expression of CASP7 protein CTD PMID:37121296 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO solasodine results in increased cleavage of and results in decreased expression of CASP9 protein CTD PMID:37121296 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cdh1 cadherin 1 increases expression
multiple interactions		 ISO solasodine results in increased expression of CDH1 protein
CLDN2 protein inhibits the reaction [solasodine results in increased expression of CDH1 protein]		 CTD PMID:37121296 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 decreases expression
multiple interactions		 ISO solasodine results in decreased expression of CDH2 mRNA; solasodine results in decreased expression of CDH2 protein
CLDN2 protein inhibits the reaction [solasodine results in decreased expression of CDH2 protein]		 CTD PMID:37121296 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cldn2 claudin 2 multiple interactions
decreases expression		 ISO acadesine promotes the reaction [solasodine results in decreased expression of CLDN2 protein]; CLDN2 protein inhibits the reaction [solasodine results in decreased expression of CDH2 protein]; CLDN2 protein inhibits the reaction [solasodine results in decreased expression of VIM protein]; CLDN2 protein inhibits the reaction [solasodine results in increased expression of CDH1 protein]
solasodine results in decreased expression of CLDN2 mRNA; solasodine results in decreased expression of CLDN2 protein		 CTD PMID:37121296 NCBI chr  X:103,459,870...103,473,794
Ensembl chr  X:103,459,780...103,474,838 		JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression ISO solasodine results in decreased expression of GPX4 protein CTD PMID:37121296 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP solasodine inhibits the reaction [Ovalbumin results in increased secretion of IL1B protein] CTD PMID:36084726 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 multiple interactions EXP solasodine inhibits the reaction [Ovalbumin results in increased secretion of IL4 protein] CTD PMID:36084726 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 multiple interactions EXP solasodine inhibits the reaction [Ovalbumin results in increased secretion of IL5 protein] CTD PMID:36084726 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Mir21 microRNA 21 decreases expression ISO solasodine results in decreased expression of MIR21; solasodine results in decreased expression of MIR21 mRNA CTD PMID:28283413 PMID:37121296 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO solasodine results in decreased expression of MMP2 mRNA CTD PMID:28283413 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO solasodine results in decreased expression of MMP9 mRNA CTD PMID:28283413 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO solasodine results in increased cleavage of and results in decreased expression of PARP1 protein CTD PMID:37121296 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases phosphorylation ISO solasodine results in increased phosphorylation of PRKAA1 protein CTD PMID:37121296 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Reck reversion-inducing-cysteine-rich protein with kazal motifs increases expression ISO solasodine results in increased expression of RECK mRNA CTD PMID:28283413 NCBI chr 5:58,102,961...58,169,516
Ensembl chr 5:58,102,981...58,169,502 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases localization ISO solasodine results in decreased localization of RELA protein CTD PMID:37121296 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rhoa ras homolog family member A decreases expression ISO solasodine results in decreased expression of RHOA protein CTD PMID:37121296 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO solasodine results in decreased expression of SLC7A11 protein CTD PMID:37121296 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO solasodine results in decreased phosphorylation of STAT3 protein CTD PMID:37121296 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO solasodine results in increased expression of TIMP1 mRNA CTD PMID:28283413 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO solasodine results in increased expression of TIMP2 mRNA CTD PMID:28283413 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP solasodine inhibits the reaction [Ovalbumin results in increased secretion of TNF protein] CTD PMID:36084726 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vim vimentin decreases expression
multiple interactions		 ISO solasodine results in decreased expression of VIM mRNA; solasodine results in decreased expression of VIM protein
CLDN2 protein inhibits the reaction [solasodine results in decreased expression of VIM protein]		 CTD PMID:37121296 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        biochemical role 19556
          metabolite 19544
            alkaloid 8017
              steroid alkaloid 27
                (+)-buxaminol C 0
                (3S,10R,13S,17R)-3-Hydroxy-10,13-dimethyl-17-[1-(3-methyl-2,3,4,5-tetrahydropyridin-6-yl)ethyl]-1,2,3,4,5,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-6-one 0
                22-iso-teinemine 0
                25-iso-etioline 0
                31-demethylbuxaminol 0
                5,6-dehydrotomatine 0
                Buxalongifolamidine 0
                Buxamine A 0
                Buxamine E 0
                Conessine dihydrobromide 0
                Cyclobuxine D 0
                Cyclobuxophylline K 0
                Cycloprotobuxine C 0
                Cyclovirobuxine C 0
                Etioline 0
                Hapepunine 0
                LSM-6454 0
                PETILINE 0
                Samandenone 0
                Solacapine 0
                Solacongestidine 0
                Solanocapsine 0
                Teinemine 0
                buxaminol A 0
                conessine 0
                cortistatins + 0
                cyclonataminol 0
                esculeoside A 0
                hookerianamide H 0
                hookerianamide I 0
                hookerianamide J 0
                hookerianamide K 0
                isosarcodine 0
                pachyaximine A 0
                sarcocine 0
                sarcodine 0
                sarcorine 0
                solasodine + 27
                tomatine + 0
                wrightiamine A 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                organic polycyclic compound 17291
                                  steroid 14716
                                    steroid alkaloid 27
                                      (+)-buxaminol C 0
                                      (3S,10R,13S,17R)-3-Hydroxy-10,13-dimethyl-17-[1-(3-methyl-2,3,4,5-tetrahydropyridin-6-yl)ethyl]-1,2,3,4,5,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-6-one 0
                                      22-iso-teinemine 0
                                      25-iso-etioline 0
                                      31-demethylbuxaminol 0
                                      5,6-dehydrotomatine 0
                                      Buxalongifolamidine 0
                                      Buxamine A 0
                                      Buxamine E 0
                                      Conessine dihydrobromide 0
                                      Cyclobuxine D 0
                                      Cyclobuxophylline K 0
                                      Cycloprotobuxine C 0
                                      Cyclovirobuxine C 0
                                      Etioline 0
                                      Hapepunine 0
                                      LSM-6454 0
                                      PETILINE 0
                                      Samandenone 0
                                      Solacapine 0
                                      Solacongestidine 0
                                      Solanocapsine 0
                                      Teinemine 0
                                      buxaminol A 0
                                      conessine 0
                                      cortistatins + 0
                                      cyclonataminol 0
                                      esculeoside A 0
                                      hookerianamide H 0
                                      hookerianamide I 0
                                      hookerianamide J 0
                                      hookerianamide K 0
                                      isosarcodine 0
                                      pachyaximine A 0
                                      sarcocine 0
                                      sarcodine 0
                                      sarcorine 0
                                      solasodine + 27
                                      tomatine + 0
                                      wrightiamine A 0
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