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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:amoxapine
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Accession:CHEBI:2675 term browser browse the term
Definition:A dibenzooxazepine compound having a chloro substituent at the 2-position and a piperazin-1-yl group at the 11-position.
Synonyms:exact_synonym: 2-chloro-11-(piperazin-1-yl)dibenzo[b,f][1,4]oxazepine
 related_synonym: 2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine;   Desmethylloxapin;   Formula=C17H16ClN3O;   InChI=1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2;   InChIKey=QWGDMFLQWFTERH-UHFFFAOYSA-N;   SMILES=Clc1ccc2Oc3ccccc3N=C(N3CCNCC3)c2c1;   amoxapina;   amoxapinum
 xref: Beilstein:832057;   CAS:14028-44-5;   DrugBank:DB00543;   Drug_Central:191;   KEGG:D00228;   LINCS:LSM-2021
 xref_mesh: MESH:D000657
 xref: PMID:24134630;   Patent:FR1508536;   Patent:US3663696;   Wikipedia:Amoxapine



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amoxapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases chemical synthesis ISO CYP3A4 results in increased chemical synthesis of Amoxapine CTD PMID:21826677 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Drd1 dopamine receptor D1 affects binding ISO Amoxapine binds to DRD1 protein CTD PMID:11180191 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Drd2 dopamine receptor D2 affects binding ISO Amoxapine binds to DRD2 protein CTD PMID:11180191 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO Amoxapine results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA]; Amoxapine results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr 3:39,944,896...40,106,646
Ensembl chr 3:39,945,351...40,109,124
JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 multiple interactions ISO Amoxapine results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA] CTD PMID:22164246 NCBI chr 8:30,724,923...30,753,083
Ensembl chr 8:30,724,925...30,753,518
JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 multiple interactions ISO Amoxapine results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr11:34,061,705...34,309,128
Ensembl chr11:34,061,708...34,308,758
JBrowse link
G Prl prolactin increases expression ISO Amoxapine results in increased expression of PRL protein CTD PMID:6363397 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Tac1 tachykinin, precursor 1 decreases expression EXP Amoxapine results in decreased expression of TAC1 protein CTD PMID:8955926 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link

Term paths to the root
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  CHEBI ontology 19715
    role 19690
      application 19522
        pharmaceutical 19409
          drug 19409
            protective agent 18014
              geroprotector 17161
                amoxapine 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19715
    subatomic particle 19713
      composite particle 19713
        hadron 19713
          baryon 19713
            nucleon 19713
              atomic nucleus 19713
                atom 19713
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19606
                        carbon group molecular entity 19606
                          organic molecular entity 19603
                            organic molecule 19562
                              organic cyclic compound 19378
                                organic polycyclic compound 17154
                                  organic tricyclic compound 15633
                                    organic heterotricyclic compound 15591
                                      dibenzooxazepine 22
                                        amoxapine 8
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