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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:amoxapine
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Accession:CHEBI:2675 term browser browse the term
Definition:A dibenzooxazepine compound having a chloro substituent at the 2-position and a piperazin-1-yl group at the 11-position.
Synonyms:exact_synonym: 2-chloro-11-(piperazin-1-yl)dibenzo[b,f][1,4]oxazepine
 related_synonym: 2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine;   Desmethylloxapin;   Formula=C17H16ClN3O;   InChI=1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2;   InChIKey=QWGDMFLQWFTERH-UHFFFAOYSA-N;   SMILES=Clc1ccc2Oc3ccccc3N=C(N3CCNCC3)c2c1;   amoxapina;   amoxapinum
 xref: Beilstein:832057;   CAS:14028-44-5;   DrugBank:DB00543;   Drug_Central:191;   KEGG:D00228;   LINCS:LSM-2021
 xref_mesh: MESH:D000657
 xref: PMID:24134630;   Patent:FR1508536;   Patent:US3663696;   Wikipedia:Amoxapine


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amoxapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases chemical synthesis ISO CYP3A4 results in increased chemical synthesis of Amoxapine CTD PMID:21826677 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Drd1 dopamine receptor D1 affects binding ISO Amoxapine binds to DRD1 protein CTD PMID:11180191 NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,545,111...10,567,166 		JBrowse link
G Drd2 dopamine receptor D2 affects binding ISO Amoxapine binds to DRD2 protein CTD PMID:11180191 NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339 		JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO Amoxapine results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA]; Amoxapine results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr 3:60,353,990...60,518,110
Ensembl chr 3:60,354,146...60,518,104 		JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 multiple interactions ISO Amoxapine results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA] CTD PMID:22164246 NCBI chr 8:38,981,598...39,011,197
Ensembl chr 8:38,983,034...39,011,101 		JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 multiple interactions ISO Amoxapine results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr11:47,531,312...47,778,348
Ensembl chr11:47,531,312...47,778,348 		JBrowse link
G Prl prolactin increases expression ISO Amoxapine results in increased expression of PRL protein CTD PMID:6363397 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217 		JBrowse link
G Tac1 tachykinin, precursor 1 decreases expression EXP Amoxapine results in decreased expression of TAC1 protein CTD PMID:8955926 NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:36,645,571...36,653,546 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20841
    role 20801
      biological role 20799
        pharmacological role 19912
          antagonist 17589
            dopaminergic antagonist 1648
              amoxapine 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 20841
    subatomic particle 20839
      composite particle 20839
        hadron 20839
          baryon 20839
            nucleon 20839
              atomic nucleus 20839
                atom 20839
                  main group element atom 20762
                    p-block element atom 20786
                      carbon group element atom 20695
                        carbon group molecular entity 20718
                          organic molecular entity 20690
                            organic molecule 20634
                              organic cyclic compound 20385
                                organic polycyclic compound 17557
                                  organic tricyclic compound 16068
                                    organic heterotricyclic compound 16022
                                      dibenzooxazepine 22
                                        amoxapine 8
paths to the root