sphingolipid - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	sphingolipid	go back to main search page
Accession:	CHEBI:26739	browse the term
Definition:	Sphingolipids are a complex family of compounds that share a common structural feature, a sphingoid base backbone.
Synonyms:	related_synonym:	sphingolipids

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Rat (217) Mouse (219) Human (225) Chinchilla (0) Bonobo (0) Dog (2) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (219)

1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine

term browser

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Object Name

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PubMed Reference(s)

RGD Reference(s)

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G

C-X-C motif chemokine ligand 10

increases expression

KRN 7000 results in increased expression of CXCL10 protein

NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748

G

interleukin 12b

increases expression

KRN 7000 results in increased expression of IL12B protein

NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860

alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide

term browser

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Object Name

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Evidence

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PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family B member 1A

increases chemical synthesis
multiple interactions

ABCB1 protein results in increased chemical synthesis of globotriaosylceramide
Cyclosporine inhibits the reaction [ABCB1 protein results in increased chemical synthesis of globotriaosylceramide]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased chemical synthesis of globotriaosylceramide]

NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575

G

interleukin 1 beta

multiple interactions

Curcumin inhibits the reaction [IL1B protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]]; IL1B protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]; TNF protein promotes the reaction [IL1B protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]]

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

tumor necrosis factor

multiple interactions

Curcumin inhibits the reaction [TNF protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]]; TNF protein promotes the reaction [IL1B protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]]; TNF protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

alpha-galactosylceramide

term browser

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Object Name

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Evidence

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PubMed Reference(s)

RGD Reference(s)

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G

GATA binding protein 3

multiple interactions

[Ovalbumin co-treated with alpha-galactosylceramide] results in decreased expression of GATA3 mRNA

NCBI chr 2:9,861,889...9,894,845
Ensembl chr 2:9,861,889...9,894,845

G

glutamic pyruvic transaminase, soluble

multiple interactions

[Floxacillin co-treated with alpha-galactosylceramide] results in increased expression of GPT protein

NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886

G

interferon gamma

multiple interactions
increases secretion

[Alcohols co-treated with alpha-galactosylceramide] results in increased expression of IFNG protein; [Ovalbumin co-treated with alpha-galactosylceramide] results in increased secretion of IFNG protein
alpha-galactosylceramide results in increased secretion of IFNG protein

PMID:12482940 PMID:25499027 PMID:30803854

NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797

G

interleukin 10

multiple interactions

[Ovalbumin co-treated with alpha-galactosylceramide] results in decreased secretion of IL10 protein

NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711

G

interleukin 13

multiple interactions

[Ovalbumin co-treated with alpha-galactosylceramide] results in decreased secretion of IL13 protein

NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529

G

interleukin 17A

multiple interactions

[Ovalbumin co-treated with alpha-galactosylceramide] results in decreased secretion of IL17A protein

NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720

G

interleukin 4

increases secretion
multiple interactions

alpha-galactosylceramide results in increased secretion of IL4 protein
[Ovalbumin co-treated with alpha-galactosylceramide] results in decreased secretion of IL4 protein

PMID:12482940 PMID:30803854

NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496

G

interleukin 5

multiple interactions

[Ovalbumin co-treated with alpha-galactosylceramide] results in decreased secretion of IL5 protein

NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933

G

killer cell lectin-like receptor subfamily B member 1C

decreases expression

alpha-galactosylceramide results in decreased expression of KLRB1C protein

NCBI chr 6:128,755,448...128,765,514
Ensembl chr 6:128,755,448...128,766,178

G

RAR-related orphan receptor gamma

multiple interactions

[Ovalbumin co-treated with alpha-galactosylceramide] results in decreased expression of RORC mRNA alternative form

NCBI chr 3:94,280,106...94,305,583
Ensembl chr 3:94,280,101...94,305,583

G

T-box 21

multiple interactions

[Ovalbumin co-treated with alpha-galactosylceramide] results in increased expression of TBX21 mRNA

NCBI chr11:96,988,833...97,006,157
Ensembl chr11:96,988,897...97,006,157

beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer

term browser

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Object Name

Qualifiers

Evidence

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Source

PubMed Reference(s)

RGD Reference(s)

Position

G

nitric oxide synthase 2, inducible

multiple interactions

ganglioside, GD1b analog inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; ganglioside, GD1b inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

ceramide 1-phosphate

term browser

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Object Name

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G

ceramide kinase

affects abundance

CERK protein affects the abundance of ceramide 1-phosphate

NCBI chr15:86,023,302...86,070,537
Ensembl chr15:86,023,329...86,070,342

ganglioside GM1

term browser

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Object Name

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G

CD14 antigen

multiple interactions

CD14 protein affects the reaction [G(M1) Ganglioside results in increased secretion of Nitric Oxide]

NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851

G

cyclin dependent kinase inhibitor 1A

increases expression

G(M1) Ganglioside results in increased expression of CDKN1A protein

NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701

G

cyclin dependent kinase inhibitor 1B

decreases expression

G(M1) Ganglioside results in decreased expression of CDKN1B protein

NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476

G

NPC intracellular cholesterol transporter 1

affects localization

NPC1 affects the localization of G(M1) Ganglioside

NCBI chr18:12,322,751...12,369,851
Ensembl chr18:12,322,749...12,369,457

G

neurotrophic tyrosine kinase, receptor, type 1

multiple interactions

G(M1) Ganglioside inhibits the reaction [Methylmercury Compounds results in decreased phosphorylation of NTRK1 protein]; G(M1) Ganglioside inhibits the reaction [staurosporine aglycone results in decreased phosphorylation of NTRK1 protein]

NCBI chr 3:87,685,551...87,702,549
Ensembl chr 3:87,685,551...87,702,469

G

phospholipase D1

multiple interactions

PLD1 protein affects the reaction [dinitrophenyl-bovine serum albumin affects the localization of G(M1) Ganglioside]

NCBI chr 3:27,992,636...28,187,388
Ensembl chr 3:27,992,844...28,187,511

G

phospholipase D2

multiple interactions

PLD2 protein affects the reaction [dinitrophenyl-bovine serum albumin affects the localization of G(M1) Ganglioside]

NCBI chr11:70,430,318...70,448,936
Ensembl chr11:70,430,890...70,448,936

G

solute carrier family 18 (vesicular monoamine), member 2

increases expression

G(M1) Ganglioside results in increased expression of SLC18A2 mRNA

NCBI chr19:59,249,310...59,284,444
Ensembl chr19:59,249,328...59,284,444

G

solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

increases expression

G(M1) Ganglioside results in increased expression of SLC6A3 mRNA

NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791

G

tyrosine hydroxylase

increases activity

G(M1) Ganglioside results in increased activity of TH protein

NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865

G

toll-like receptor 4

decreases expression

G(M1) Ganglioside results in decreased expression of TLR4 protein

NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521

myriocin

term browser

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G

acetyl-Coenzyme A carboxylase alpha

multiple interactions

thermozymocidin inhibits the reaction [Dexamethasone results in increased expression of ACACA mRNA]

NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477

G

angiopoietin-like 4

increases expression

thermozymocidin results in increased expression of ANGPTL4 mRNA

NCBI chr17:33,993,874...34,000,549
Ensembl chr17:33,992,724...34,000,804

G

caspase 3

multiple interactions

thermozymocidin inhibits the reaction [Dronabinol results in increased activity of CASP3 protein]; thermozymocidin inhibits the reaction [gamma-Tocopherol results in increased activity of CASP3 protein]

PMID:15596715 PMID:16818650

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

DNA-damage inducible transcript 3

multiple interactions

thermozymocidin inhibits the reaction [fumonisin B1 results in increased expression of DDIT3 protein]; thermozymocidin inhibits the reaction [Resveratrol results in increased expression of DDIT3 protein]

PMID:24264887 PMID:31891755

NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157

G

Fas cell surface death receptor

multiple interactions

thermozymocidin inhibits the reaction [[sorafenib co-treated with vorinostat] affects the localization of and results in increased activity of FAS protein]

NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172

G

fatty acid synthase

multiple interactions

[thermozymocidin results in increased susceptibility to Dexamethasone] which results in decreased expression of FASN mRNA

NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373

G

heat shock protein 5

multiple interactions

thermozymocidin inhibits the reaction [fumonisin B1 results in increased expression of HSPA5 protein]

NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions

thermozymocidin inhibits the reaction [Dronabinol results in increased expression of and affects the localization of and affects the lipidation of MAP1LC3B protein]

NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499

G

nuclear protein transcription regulator 1

multiple interactions

thermozymocidin inhibits the reaction [Dronabinol results in increased expression of NUPR1 mRNA]

PMID:16616335 PMID:16818650

NCBI chr 7:126,222,418...126,224,642
Ensembl chr 7:126,222,421...126,230,033

G

ornithine decarboxylase, structural 1

multiple interactions

thermozymocidin inhibits the reaction [resveratrol results in decreased activity of ODC1 protein]

NCBI chr12:17,594,906...17,601,503
Ensembl chr12:17,594,795...17,601,506

G

poly (ADP-ribose) polymerase family, member 1

multiple interactions

thermozymocidin inhibits the reaction [resveratrol results in increased cleavage of PARP1 protein]

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

protein kinase C, zeta

decreases activity

thermozymocidin results in decreased activity of PRKCZ protein

NCBI chr 4:155,344,579...155,445,856
Ensembl chr 4:155,344,586...155,445,818

N,N-dimethylsphingosine

term browser

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Object Name

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Evidence

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PubMed Reference(s)

RGD Reference(s)

Position

G

c-abl oncogene 1, non-receptor tyrosine kinase

multiple interactions

[Bortezomib co-treated with N,N-dimethylsphingosine] results in decreased expression of ABL1 protein

NCBI chr 2:31,578,256...31,697,105
Ensembl chr 2:31,578,388...31,694,239

G

N-acylsphingosine amidohydrolase 2

multiple interactions

N,N-dimethylsphingosine inhibits the reaction [ASAH2 protein results in increased expression of BCL2 protein]

NCBI chr19:31,962,046...32,080,540
Ensembl chr19:31,959,997...32,085,611

G

B cell leukemia/lymphoma 2

multiple interactions

N,N-dimethylsphingosine inhibits the reaction [ASAH2 protein results in increased expression of BCL2 protein]

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

caspase 3

multiple interactions

[Bortezomib co-treated with N,N-dimethylsphingosine] results in increased cleavage of and results in increased activity of CASP3 protein

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

fibronectin 1

multiple interactions

N,N-dimethylsphingosine inhibits the reaction [Glucose results in increased expression of FN1 protein]

NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359

G

hemolytic complement

multiple interactions

N,N-dimethylsphingosine inhibits the reaction [C5 protein results in increased activity of RELA protein]

NCBI chr 2:34,873,341...34,958,518
Ensembl chr 2:34,873,343...34,951,450

G

myeloid cell leukemia sequence 1

multiple interactions

[Bortezomib co-treated with N,N-dimethylsphingosine] results in decreased expression of MCL1 protein

NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487

G

poly (ADP-ribose) polymerase family, member 1

multiple interactions

[Bortezomib co-treated with N,N-dimethylsphingosine] results in increased cleavage of PARP1 protein

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions

N,N-dimethylsphingosine inhibits the reaction [C5 protein results in increased activity of RELA protein]

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

sphingosine kinase 1

decreases activity
multiple interactions
decreases expression

N,N-dimethylsphingosine results in decreased activity of SPHK1 protein
N,N-dimethylsphingosine inhibits the reaction [Glucose results in increased activity of SPHK1 protein]
N,N-dimethylsphingosine results in decreased expression of SPHK1 protein

PMID:17065523 PMID:19284563 PMID:21195056 PMID:21998146

NCBI chr11:116,421,662...116,427,502
Ensembl chr11:116,421,751...116,427,501

N-\{6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl\}sphingosine

term browser

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PubMed Reference(s)

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Position

G

ATP-binding cassette, sub-family B member 1A

increases transport

ABCB1 protein results in increased transport of N-(7-(4-nitrobenzo-2-oxa-1,3-diazole))-6-aminocaproyl sphingosine

NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575

N-acetylsphingosine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family B member 1A

increases expression

N-acetylsphingosine results in increased expression of ABCB1

NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575

G

thymoma viral proto-oncogene 1

multiple interactions
decreases phosphorylation

BCL2 protein inhibits the reaction [N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; N-acetylsphingosine inhibits the reaction [CAV1 protein results in increased phosphorylation of AKT1 protein]; N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of AKT1 protein
N-acetylsphingosine results in decreased phosphorylation of AKT1 protein

PMID:12640124 PMID:16215670 PMID:21821001

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

BCL2-associated agonist of cell death

multiple interactions
decreases phosphorylation

N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in decreased phosphorylation of BAD protein]

NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267

G

BCL2-associated X protein

increases expression
multiple interactions

N-acetylsphingosine results in increased expression of BAX mRNA
N-acetylsphingosine promotes the reaction [Acetaminophen results in increased expression of BAX protein]

PMID:24420784 PMID:33959992

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

B cell leukemia/lymphoma 2

multiple interactions
decreases expression

BCL2 protein inhibits the reaction [N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased cleavage of and results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased degradation of PLCG1 protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 mRNA]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 protein]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 protein]
N-acetylsphingosine results in decreased expression of BCL2 mRNA; N-acetylsphingosine results in decreased expression of BCL2 protein

PMID:9295281 PMID:16215670 PMID:24420784

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

BCL2-like 1

multiple interactions
increases degradation

LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of BCL2L1 protein]

NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648

G

baculoviral IAP repeat-containing 2

decreases expression

[C2-ceramide cotreated with paclitaxel] decreases expression of BIRC2 mRNA in non-small cell lung cancer cells

RGD

NCBI chr 9:7,818,227...7,837,123
Ensembl chr 9:7,818,228...7,837,065

G

baculoviral IAP repeat-containing 3

decreases expression

[C2-ceramide cotreated with paclitaxel] decreases expression of BIRC3 mRNA in non-small cell lung cancer cells

RGD

NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187

G

caspase 3

multiple interactions
increases activity

BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased cleavage of and results in increased activity of CASP3 protein]; N-acetylsphingosine promotes the reaction [Acetaminophen results in increased expression of CASP3 protein]; N-acetylsphingosine results in increased cleavage of and results in increased activity of CASP3 protein
N-acetylsphingosine results in increased activity of CASP3 protein

PMID:10919278 PMID:16215670 PMID:21259059 PMID:28052715 PMID:33959992

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caveolin 1, caveolae protein

multiple interactions

N-acetylsphingosine inhibits the reaction [CAV1 protein results in increased phosphorylation of AKT1 protein]

NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451

G

CCAAT/enhancer binding protein beta

multiple interactions
decreases localization

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [N-acetylsphingosine results in decreased localization of CEBPB protein]; N-acetylsphingosine inhibits the reaction [oltipraz results in increased localization of CEBPB protein]

NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338

G

cystic fibrosis transmembrane conductance regulator

increases activity

N-acetylsphingosine results in increased activity of CFTR protein

NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767

G

claudin 4

decreases expression

N-acetylsphingosine results in decreased expression of CLDN4 mRNA; N-acetylsphingosine results in decreased expression of CLDN4 protein

NCBI chr 5:134,973,977...134,975,788
Ensembl chr 5:134,973,973...134,975,788

G

CDC-like kinase 1

increases expression

N-acetylsphingosine results in increased expression of CLK1 mRNA

NCBI chr 1:58,451,147...58,463,247
Ensembl chr 1:58,449,348...58,463,225

G

cathepsin D

increases secretion

N-acetylsphingosine results in increased secretion of CTSD protein

NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775

G

death associated protein kinase 1

increases activity

N-acetylsphingosine results in increased activity of DAPK1 protein

NCBI chr13:60,749,506...60,911,005
Ensembl chr13:60,749,761...60,911,005

G

DNA fragmentation factor, beta subunit

increases activity

N-acetylsphingosine results in increased activity of DFFB protein

NCBI chr 4:154,048,904...154,059,578
Ensembl chr 4:154,048,906...154,059,583

G

dynamin 1-like

increases expression

N-acetylsphingosine results in increased expression of DNM1L protein

NCBI chr16:16,130,092...16,176,863
Ensembl chr16:16,130,094...16,176,823

G

epidermal growth factor

multiple interactions

N-acetylsphingosine inhibits the reaction [EGF protein results in increased abundance of Diglycerides]

NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965

G

coagulation factor III

increases expression
multiple interactions

N-acetylsphingosine results in increased expression of F3 protein
N-acetylsphingosine promotes the reaction [IL1B protein results in increased expression of F3 protein]

NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697

G

fission, mitochondrial 1

increases expression

N-acetylsphingosine results in increased expression of FIS1 protein

NCBI chr 5:136,982,129...136,995,088
Ensembl chr 5:136,982,129...136,995,088

G

glutamic-oxaloacetic transaminase 1, soluble

multiple interactions

N-acetylsphingosine promotes the reaction [Acetaminophen results in increased activity of GOT1 protein]

NCBI chr19:43,488,191...43,514,743
Ensembl chr19:43,488,191...43,513,044

G

glutamic pyruvic transaminase, soluble

multiple interactions

N-acetylsphingosine promotes the reaction [Acetaminophen results in increased activity of GPT protein]

NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886

G

glutathione peroxidase 3

multiple interactions

N-acetylsphingosine promotes the reaction [Acetaminophen results in decreased activity of GPX3 protein]

NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203

G

glycogen synthase kinase 3 alpha

decreases phosphorylation

N-acetylsphingosine results in decreased phosphorylation of GSK3A protein

NCBI chr 7:24,927,683...24,937,276
Ensembl chr 7:24,927,683...24,937,276

G

glycogen synthase kinase 3 beta

decreases phosphorylation
decreases expression
multiple interactions

N-acetylsphingosine results in decreased phosphorylation of GSK3B protein
N-acetylsphingosine results in decreased expression of GSK3B protein modified form
GSK3B mutant form inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein]

PMID:21821001 PMID:24420784

NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446

G

glutathione S-transferase, alpha 1 (Ya)

decreases expression

N-acetylsphingosine results in decreased expression of GSTA5 protein

NCBI chr 9:78,137,951...78,149,965
Ensembl chr 9:78,137,938...78,149,966

G

glutathione S-transferase, alpha 2 (Yc2)

multiple interactions
decreases expression

N-acetylsphingosine inhibits the reaction [2-tert-butylhydroquinone results in increased expression of GSTA2 protein]; N-acetylsphingosine inhibits the reaction [oltipraz results in increased expression of GSTA2 protein]
N-acetylsphingosine results in decreased expression of GSTA2 protein

PMID:15155840 PMID:15319326

NCBI chr 9:78,238,300...78,254,474
Ensembl chr 9:78,238,300...78,263,070

G

heme oxygenase 1

decreases expression

N-acetylsphingosine results in decreased expression of HMOX1 mRNA

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

HNF1 homeobox A

multiple interactions
decreases ubiquitination

N-acetylsphingosine results in decreased expression of and results in decreased activity of HNF1A protein
N-acetylsphingosine promotes the reaction [Acetaminophen results in decreased expression of HNF1A mRNA]; N-acetylsphingosine promotes the reaction [Acetaminophen results in decreased expression of HNF1A protein]
N-acetylsphingosine results in decreased ubiquitination of HNF1A protein

PMID:15155840 PMID:31385618 PMID:33959992

NCBI chr 5:115,087,039...115,109,121
Ensembl chr 5:115,087,039...115,109,153

G

harakiri, BCL2 interacting protein (contains only BH3 domain)

increases expression
multiple interactions

N-acetylsphingosine results in increased expression of HRK mRNA
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in increased expression of HRK mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in increased expression of HRK mRNA]

NCBI chr 5:118,307,829...118,327,543
Ensembl chr 5:118,302,713...118,327,543

G

inhibitor of DNA binding 2

decreases expression

N-acetylsphingosine results in decreased expression of ID2 mRNA

NCBI chr12:25,143,798...25,146,091
Ensembl chr12:25,143,798...25,147,139

G

interleukin 16

increases expression

N-acetylsphingosine results in increased expression of IL16 mRNA

NCBI chr 7:83,292,027...83,395,479
Ensembl chr 7:83,292,033...83,394,934

G

interleukin 1 beta

multiple interactions

N-acetylsphingosine promotes the reaction [IL1B protein results in increased expression of F3 protein]

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

jun proto-oncogene

multiple interactions

N-acetylsphingosine promotes the reaction [Acetaminophen results in increased phosphorylation of JUN protein]

NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459

G

kinase insert domain protein receptor

multiple interactions

N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of KDR protein
sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of KDR mRNA]

PMID:15313899 PMID:15741222

NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118

G

Kruppel-like transcription factor 6

increases expression

N-acetylsphingosine results in increased expression of KLF6 mRNA

NCBI chr13:5,911,488...5,920,392
Ensembl chr13:5,911,481...5,920,393

G

lectin, galactose binding, soluble 3

multiple interactions
increases expression
decreases response to substance

4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein]; GSK3B mutant form inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein]; LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of BCL2L1 protein]; LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of MCL1 protein]
LGALS3 results in decreased susceptibility to N-acetylsphingosine

NCBI chr14:47,611,317...47,623,624
Ensembl chr14:47,605,208...47,623,617

G

mitogen-activated protein kinase kinase kinase 5

multiple interactions

N-acetylsphingosine affects the phosphorylation of and results in increased activity of MAP3K5 protein; TXNIP affects the reaction [N-acetylsphingosine affects the phosphorylation of and results in increased activity of MAP3K5 protein]

NCBI chr10:19,809,847...20,018,496
Ensembl chr10:19,810,218...20,018,499

G

mitogen-activated protein kinase 1

increases activity

N-acetylsphingosine results in increased activity of MAPK1 protein

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

increases activity

N-acetylsphingosine results in increased activity of MAPK3 protein

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

mitogen-activated protein kinase 8

multiple interactions

N-acetylsphingosine promotes the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein]

NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115

G

mitogen-activated protein kinase 9

multiple interactions

N-acetylsphingosine results in increased phosphorylation of and results in increased activity of MAPK9 protein; TXNIP affects the reaction [N-acetylsphingosine results in increased phosphorylation of and results in increased activity of MAPK9 protein]

NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248

G

myeloid cell leukemia sequence 1

multiple interactions
increases degradation

LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of MCL1 protein]

NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487

G

transformed mouse 3T3 cell double minute 2

decreases expression

N-acetylsphingosine results in decreased expression of MDM2 mRNA; N-acetylsphingosine results in decreased expression of MDM2 protein

NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663

G

mitofusin 2

decreases response to substance

MFN2 protein results in decreased susceptibility to N-acetylsphingosine

NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161

G

microRNA 15b

decreases expression

N-acetylsphingosine results in decreased expression of MIR15B mRNA

NCBI chr 3:68,917,105...68,917,168
Ensembl chr 3:68,917,105...68,917,168

G

microRNA 20a

decreases expression

N-acetylsphingosine results in decreased expression of MIR20A mRNA

NCBI chr14:115,281,589...115,281,695
Ensembl chr14:115,281,589...115,281,695

G

microRNA 25

decreases expression

N-acetylsphingosine results in decreased expression of MIR25 mRNA

NCBI chr 5:138,163,583...138,163,666
Ensembl chr 5:138,163,583...138,163,666

G

microRNA 93

decreases expression

N-acetylsphingosine results in decreased expression of MIR93 mRNA

NCBI chr 5:138,163,785...138,163,872
Ensembl chr 5:138,163,785...138,163,872

G

microRNA let7b

decreases expression

N-acetylsphingosine results in decreased expression of MIRLET7B mRNA

NCBI chr15:85,591,520...85,591,604
Ensembl chr15:85,591,520...85,591,604

G

microRNA let7d

decreases expression

N-acetylsphingosine results in decreased expression of MIRLET7D mRNA

NCBI chr13:48,689,488...48,689,590
Ensembl chr13:48,689,488...48,689,590

G

microRNA let7e

decreases expression

N-acetylsphingosine results in decreased expression of MIRLET7E mRNA

NCBI chr17:18,050,614...18,050,706
Ensembl chr17:18,050,614...18,050,706

G

microRNA let7i

decreases expression

N-acetylsphingosine results in decreased expression of MIRLET7I mRNA

NCBI chr10:122,821,545...122,821,629
Ensembl chr10:122,821,545...122,821,629

G

nuclear factor, erythroid derived 2, like 2

multiple interactions
decreases localization

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [N-acetylsphingosine results in decreased localization of NFE2L2 protein]; N-acetylsphingosine inhibits the reaction [2-tert-butylhydroquinone results in increased localization of NFE2L2 protein]

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

nerve growth factor

multiple interactions

N-acetylsphingosine affects the reaction [Glutathione affects the activity of NGF protein]

NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329

G

neuropilin 1

multiple interactions

sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP1 mRNA]

NCBI chr 8:129,085,553...129,231,957
Ensembl chr 8:129,085,085...129,229,844

G

neuropilin 2

multiple interactions

sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP2 mRNA]

NCBI chr 1:62,742,476...62,857,851
Ensembl chr 1:62,742,444...62,857,854

G

occludin

decreases expression

N-acetylsphingosine results in decreased expression of OCLN mRNA; N-acetylsphingosine results in decreased expression of OCLN protein

NCBI chr13:100,633,012...100,689,226
Ensembl chr13:100,633,015...100,689,226

G

ornithine decarboxylase, structural 1

decreases activity

N-acetylsphingosine results in decreased activity of ODC1 protein

NCBI chr12:17,594,906...17,601,503
Ensembl chr12:17,594,795...17,601,506

G

poly (ADP-ribose) polymerase family, member 1

increases activity

N-acetylsphingosine results in increased activity of PARP1 protein

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

PTEN induced putative kinase 1

decreases response to substance

PINK1 protein results in decreased susceptibility to N-acetylsphingosine

NCBI chr 4:138,040,718...138,053,631
Ensembl chr 4:138,040,720...138,053,618

G

plasminogen activator, tissue

multiple interactions

[N-acetylsphingosine results in increased abundance of Ceramides] which results in increased secretion of PLAT protein

NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860

G

phospholipase C, gamma 1

multiple interactions
increases degradation

BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased degradation of PLCG1 protein]

NCBI chr 2:160,573,230...160,617,680
Ensembl chr 2:160,573,220...160,617,680

G

v-raf-leukemia viral oncogene 1

increases activity

N-acetylsphingosine results in increased activity of RAF1 protein

NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

affects activity

N-acetylsphingosine affects the activity of RELA protein

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

ras homolog family member B

increases expression

N-acetylsphingosine results in increased expression of RHOB mRNA

NCBI chr12:8,547,661...8,550,009
Ensembl chr12:8,547,661...8,550,009

G

serine (or cysteine) peptidase inhibitor, clade E, member 1

multiple interactions

[N-acetylsphingosine results in increased abundance of Ceramides] which results in decreased secretion of SERPINE1 protein

NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122

G

superoxide dismutase 1, soluble

multiple interactions

N-acetylsphingosine promotes the reaction [Acetaminophen results in decreased activity of SOD1 protein]

NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217

G

superoxide dismutase 2, mitochondrial

increases expression
multiple interactions

N-acetylsphingosine results in increased expression of SOD2 mRNA; N-acetylsphingosine results in increased expression of SOD2 protein
Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of SOD2 protein]

PMID:9535218 PMID:10428046

NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950

G

steroid sulfatase

multiple interactions

N-acetylsphingosine inhibits the reaction [Tretinoin results in increased activity of STS protein]

NCBI chr X:168,856,332...169,015,037
Ensembl chr X:168,909,030...169,014,924

G

transcription factor E3

multiple interactions

N-acetylsphingosine results in decreased phosphorylation of and affects the localization of TFE3 protein

NCBI chr X:7,628,769...7,641,441
Ensembl chr X:7,628,799...7,641,441

G

TGFB-induced factor homeobox 1

increases expression

N-acetylsphingosine results in increased expression of TGIF1 mRNA

NCBI chr17:71,151,200...71,160,527
Ensembl chr17:71,151,200...71,160,541

G

tight junction protein 1

decreases expression

N-acetylsphingosine results in decreased expression of TJP1 mRNA; N-acetylsphingosine results in decreased expression of TJP1 protein

NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529

G

transformation related protein 53

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of TP53 mRNA]; Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of TP53 protein]
N-acetylsphingosine results in increased expression of TP53 mRNA; N-acetylsphingosine results in increased expression of TP53 protein

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

G

thioredoxin 1

decreases activity
multiple interactions

N-acetylsphingosine results in decreased activity of TXN protein
TXNIP affects the reaction [N-acetylsphingosine results in decreased activity of TXN protein]

NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411

G

thioredoxin interacting protein

increases expression
multiple interactions

N-acetylsphingosine results in increased expression of TXNIP protein
N-acetylsphingosine results in increased expression of TXNIP mRNA; N-acetylsphingosine results in increased expression of TXNIP protein
TXNIP affects the reaction [N-acetylsphingosine affects the phosphorylation of and results in increased activity of MAP3K5 protein]; TXNIP affects the reaction [N-acetylsphingosine results in decreased activity of TXN protein]; TXNIP affects the reaction [N-acetylsphingosine results in increased phosphorylation of and results in increased activity of MAPK9 protein]

NCBI chr 3:96,465,273...96,469,173
Ensembl chr 3:96,465,273...96,469,199

G

vascular endothelial growth factor A

multiple interactions

N-acetylsphingosine results in decreased expression of and results in decreased secretion of VEGFA protein

NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295

N-acylsphinganine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

activating transcription factor 4

increases expression

dihydroceramide analog results in increased expression of ATF4 protein

NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742

G

caspase 3

increases cleavage

dihydroceramide metabolite results in increased cleavage of CASP3 protein

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 6

increases cleavage

dihydroceramide metabolite results in increased cleavage of CASP6 protein

NCBI chr 3:129,695,064...129,707,761
Ensembl chr 3:129,695,074...129,707,752

G

caspase 9

increases cleavage

dihydroceramide metabolite results in increased cleavage of CASP9 protein

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

delta 4-desaturase, sphingolipid 1

multiple interactions

[N-((1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl)octanamide results in decreased activity of DEGS1 protein] which results in decreased reduction of dihydroceramide

NCBI chr 1:182,103,529...182,110,366
Ensembl chr 1:182,103,337...182,110,369

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions

dihydroceramide analog results in increased expression of and results in increased lipidation of MAP1LC3B protein

NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499

G

tribbles pseudokinase 3

increases expression

dihydroceramide analog results in increased expression of TRIB3 protein

NCBI chr 2:152,179,345...152,185,980
Ensembl chr 2:152,179,342...152,185,952

N-hexadecanoylsphingosine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

N-acylsphingosine amidohydrolase 2

multiple interactions

ASAH2 protein inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine]

NCBI chr19:31,962,046...32,080,540
Ensembl chr19:31,959,997...32,085,611

G

activating transcription factor 4

multiple interactions
increases expression

ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ATF4 mRNA]

NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742

G

activating transcription factor 6

increases expression
multiple interactions

N-palmitoylsphingosine results in increased expression of ATF6 mRNA
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ATF6 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ATF6 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ATF6 mRNA]

NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340

G

citrate synthase

multiple interactions
decreases expression

[N-palmitoylsphingosine co-treated with Dietary Fats] results in decreased activity of CS protein; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in decreased activity of CS protein]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in decreased expression of CS mRNA]

NCBI chr10:128,173,596...128,198,351
Ensembl chr10:128,173,603...128,198,348

G

DNA-damage inducible transcript 3

increases expression
multiple interactions

N-palmitoylsphingosine results in increased expression of DDIT3 mRNA
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of DDIT3 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of DDIT3 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of DDIT3 mRNA]

NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157

G

heat shock protein 5

increases expression
multiple interactions

N-palmitoylsphingosine results in increased expression of HSPA5 mRNA
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of HSPA5 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of HSPA5 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of HSPA5 mRNA]

NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559

G

interleukin 1 beta

increases abundance
multiple interactions

IL1B protein results in increased abundance of N-palmitoylsphingosine
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [IL1B protein results in increased abundance of N-palmitoylsphingosine]

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

inositol 1,4,5-trisphosphate receptor 1

multiple interactions
increases expression

[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR1 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR1 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ITPR1 mRNA]

NCBI chr 6:108,190,044...108,528,077
Ensembl chr 6:108,190,057...108,528,070

G

inositol 1,4,5-triphosphate receptor 2

increases expression
multiple interactions

N-palmitoylsphingosine results in increased expression of ITPR2 mRNA
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR2 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR2 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ITPR2 mRNA]

NCBI chr 6:146,009,797...146,403,757
Ensembl chr 6:146,009,797...146,403,721

G

lipase, hepatic

multiple interactions

[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of N-palmitoylsphingosine

NCBI chr 9:70,705,410...70,859,503
Ensembl chr 9:70,705,410...70,859,508

G

lipase, endothelial

multiple interactions

[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of N-palmitoylsphingosine

NCBI chr18:75,072,393...75,095,380
Ensembl chr18:75,072,393...75,094,334

G

mitofusin 2

increases expression
multiple interactions

N-palmitoylsphingosine results in increased expression of MFN2 mRNA
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of MFN2 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of MFN2 mRNA]

NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161

G

phosphofurin acidic cluster sorting protein 2

increases expression
multiple interactions

N-palmitoylsphingosine results in increased expression of PACS2 mRNA
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of PACS2 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of PACS2 mRNA]

NCBI chr12:112,977,998...113,038,021
Ensembl chr12:112,978,128...113,038,021

G

pyruvate carboxylase

multiple interactions

[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased activity of PC protein; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased activity of PC protein]

NCBI chr19:4,560,500...4,671,780
Ensembl chr19:4,560,500...4,671,780

G

tumor necrosis factor

increases abundance
multiple interactions

TNF protein results in increased abundance of N-palmitoylsphingosine
ASAH2 protein inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine]
Imipramine inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine]

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

voltage-dependent anion channel 1

multiple interactions

[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of VDAC1 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of VDAC1 mRNA]

NCBI chr11:52,251,905...52,280,224
Ensembl chr11:52,251,687...52,280,224

phytosphingosine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apoptosis-inducing factor, mitochondrion-associated 1

affects localization
multiple interactions

phytosphingosine affects the localization of AIFM1 protein
3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [phytosphingosine affects the localization of AIFM1 protein]

NCBI chr X:47,563,821...47,602,440
Ensembl chr X:47,563,821...47,602,440

G

BCL2-associated X protein

multiple interactions
increases expression
affects localization

3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein]; [arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein; Acetylcysteine inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein]; SB 203580 inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein]
phytosphingosine results in increased expression of BAX protein
phytosphingosine affects the localization of BAX protein

PMID:15486061 PMID:17237268 PMID:36334778 PMID:37956922

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

B cell leukemia/lymphoma 2

increases expression

phytosphingosine results in increased expression of BCL2 protein

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

caspase 3

multiple interactions
increases expression

3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of CASP3 protein]; [Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of CASP3 protein; phytosphingosine results in increased expression of and results in increased cleavage of CASP3 protein; SB 203580 inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of CASP3 protein]
phytosphingosine results in increased expression of CASP3 protein

PMID:17237268 PMID:36334778 PMID:37956922

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 9

multiple interactions
increases expression

3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP9 protein]; [arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP9 protein; SB 203580 inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP9 protein]
phytosphingosine results in increased expression of CASP9 protein

PMID:17237268 PMID:37956922

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

cyclin B1

decreases expression

phytosphingosine results in decreased expression of CCNB1 protein

NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078

G

cyclin dependent kinase 1

decreases expression

phytosphingosine results in decreased expression of CDK1 protein

NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768

G

cytochrome c, somatic

increases expression

phytosphingosine results in increased expression of CYCS protein

NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518

G

mitogen-activated protein kinase 1

multiple interactions

[arsenic trioxide co-treated with phytosphingosine] results in decreased phosphorylation of MAPK1 protein

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 14

multiple interactions

3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased phosphorylation of MAPK14 protein]; [arsenic trioxide co-treated with phytosphingosine] results in increased phosphorylation of MAPK14 protein; Acetylcysteine inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased phosphorylation of MAPK14 protein]

NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380

G

mitogen-activated protein kinase 3

multiple interactions

[arsenic trioxide co-treated with phytosphingosine] results in decreased phosphorylation of MAPK3 protein

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

poly (ADP-ribose) polymerase family, member 1

multiple interactions
increases cleavage
increases activity

3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased activity of PARP1 protein]; [arsenic trioxide co-treated with phytosphingosine] results in increased activity of PARP1 protein; [arsenic trioxide co-treated with phytosphingosine] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased activity of PARP1 protein]
phytosphingosine results in increased cleavage of PARP1 protein
phytosphingosine results in increased activity of PARP1 protein

PMID:15486061 PMID:17237268 PMID:37956922

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

PTEN induced putative kinase 1

decreases expression

phytosphingosine results in decreased expression of PINK1 protein

NCBI chr 4:138,040,718...138,053,631
Ensembl chr 4:138,040,720...138,053,618

rosuvastatin calcium

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family A member 1

decreases expression
multiple interactions

Rosuvastatin Calcium results in decreased expression of ABCA1 mRNA
Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of ABCA1 mRNA]

NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895

G

ATP-binding cassette, sub-family B member 11

multiple interactions

Rosuvastatin Calcium inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]
[Cyclosporine results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium; [Glyburide results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium; [troglitazone results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium

PMID:15901796 PMID:19853032

NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958

G

ATP-binding cassette, sub-family member 2

multiple interactions
increases expression
affects secretion

ABCC2 protein binds to and results in increased uptake of Rosuvastatin Calcium analog; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]
Rosuvastatin Calcium results in increased expression of ABCC2 protein
[Benzbromarone results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; [Probenecid results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; [Sulfasalazine results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; ABCC2 protein binds to and results in increased uptake of Rosuvastatin Calcium analog; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Rosuvastatin Calcium promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]
ABCC2 protein affects the secretion of Rosuvastatin Calcium

PMID:19853032 PMID:23562342 PMID:24909372

NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179

G

ATP-binding cassette, sub-family C member 3

increases expression

Rosuvastatin Calcium results in increased expression of ABCC3 protein

NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823

G

ATP binding cassette subfamily G member 1

decreases expression

Rosuvastatin Calcium results in decreased expression of ABCG1 mRNA

NCBI chr17:31,276,668...31,336,958
Ensembl chr17:31,276,649...31,336,962

G

ATP binding cassette subfamily G member 2 (Junior blood group)

multiple interactions
increases activity

[Novobiocin results in decreased activity of ABCG2 protein] which results in decreased secretion of Rosuvastatin Calcium
Rosuvastatin Calcium results in increased activity of ABCG2 protein

PMID:19853032 PMID:30083819

NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661

G

acetylcholinesterase

multiple interactions

[Piracetam co-treated with Rosuvastatin Calcium] inhibits the reaction [[Sodium Chloride, Dietary co-treated with Cholesterol, Dietary co-treated with Coconut Oil] results in increased activity of ACHE protein]; Rosuvastatin Calcium inhibits the reaction [[Sodium Chloride, Dietary co-treated with Cholesterol, Dietary co-treated with Coconut Oil] results in increased activity of ACHE protein]

NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728

G

thymoma viral proto-oncogene 1

affects phosphorylation

Rosuvastatin Calcium affects the phosphorylation of AKT1 protein

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

apolipoprotein A-I

multiple interactions
increases expression

Niacin promotes the reaction [Rosuvastatin Calcium results in increased expression of APOA1 protein]

PMID:12767421 PMID:15539964

NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764

G

apolipoprotein B

decreases expression

Rosuvastatin Calcium results in decreased expression of APOB protein

PMID:15539964 PMID:18702965

NCBI chr12:8,027,629...8,066,839
Ensembl chr12:8,027,648...8,066,835

G

BCL2-associated X protein

multiple interactions

Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of BAX mRNA]

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

B cell leukemia/lymphoma 2

decreases expression

Rosuvastatin Calcium results in decreased expression of BCL2 protein

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

complement component 3

decreases expression

Rosuvastatin Calcium results in decreased expression of C3 mRNA

NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136

G

caspase 3

increases activity
increases expression

Rosuvastatin Calcium results in increased activity of CASP3 protein
Rosuvastatin Calcium results in increased expression of CASP3 protein

PMID:21478229 PMID:32771489

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

catalase

increases activity
multiple interactions

Rosuvastatin Calcium results in increased activity of CAT protein
[Rosuvastatin Calcium co-treated with Isoproterenol] inhibits the reaction [Interleukin-6 results in increased expression of CAT protein]; Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]

PMID:20146376 PMID:32007421 PMID:35130744

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

C-C motif chemokine ligand 2

decreases expression

Rosuvastatin Calcium results in decreased expression of CCL2 mRNA

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

cAMP responsive element binding protein 5

decreases expression

Rosuvastatin Calcium results in decreased expression of CREB5 mRNA

NCBI chr 6:53,264,154...53,677,349
Ensembl chr 6:53,264,255...53,677,361

G

C-reactive protein, pentraxin-related

multiple interactions

Rosuvastatin Calcium inhibits the reaction [CRP protein results in decreased expression of NOS3]

NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598

G

cytochrome b-245, alpha polypeptide

multiple interactions
decreases expression

[[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species

NCBI chr 8:123,151,510...123,159,679
Ensembl chr 8:123,151,515...123,159,669

G

cytochrome b-245, beta polypeptide

multiple interactions
decreases expression

Rosuvastatin Calcium inhibits the reaction [Nitroglycerin results in increased expression of CYBB mRNA]
[[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species

PMID:16633368 PMID:21562509

NCBI chr X:9,301,493...9,354,005
Ensembl chr X:9,301,491...9,354,010

G

estrogen receptor 1 (alpha)

decreases expression

Rosuvastatin Calcium results in decreased expression of ESR1 protein

NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614

G

glutamate-cysteine ligase, catalytic subunit

increases expression
multiple interactions

Rosuvastatin Calcium results in increased expression of GCLC mRNA
[Tetradecanoylphorbol Acetate co-treated with Rosuvastatin Calcium] results in increased expression of GCLC mRNA

NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767

G

G protein-coupled receptor 183

increases expression
multiple interactions

Rosuvastatin Calcium results in increased expression of GPR183 mRNA
Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in increased expression of GPR183 mRNA]

NCBI chr14:122,189,743...122,202,605
Ensembl chr14:122,189,963...122,202,607

G

granzyme K

multiple interactions
increases expression

Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in increased expression of GZMK mRNA]

NCBI chr13:113,308,164...113,317,499
Ensembl chr13:113,308,142...113,362,442

G

hepatic nuclear factor 4, alpha

increases secretion

HNF4A protein results in increased secretion of Rosuvastatin Calcium

NCBI chr 2:163,348,731...163,414,827
Ensembl chr 2:163,348,728...163,414,830

G

interleukin 18 receptor accessory protein

decreases expression
multiple interactions

Rosuvastatin Calcium results in decreased expression of IL18RAP mRNA
Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of IL18RAP mRNA]

NCBI chr 1:40,554,548...40,590,867
Ensembl chr 1:40,554,522...40,590,865

G

interleukin 1 beta

decreases expression

Rosuvastatin Calcium results in decreased expression of IL1B mRNA

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

potassium voltage-gated channel, subfamily H (eag-related), member 2

decreases activity

Rosuvastatin Calcium results in decreased activity of KCNH2 protein

NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602

G

potassium inwardly-rectifying channel, subfamily J, member 15

decreases expression

Rosuvastatin Calcium results in decreased expression of KCNJ15 mRNA

NCBI chr16:95,058,417...95,101,119
Ensembl chr16:95,058,417...95,101,119

G

kinase insert domain protein receptor

multiple interactions

Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein]

NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118

G

myoglobin

affects expression

Rosuvastatin Calcium affects the expression of MB protein

NCBI chr15:76,899,687...76,934,868
Ensembl chr15:76,899,687...76,934,870

G

myostatin

increases expression

Rosuvastatin Calcium results in increased expression of MSTN protein

NCBI chr 1:53,100,799...53,107,238
Ensembl chr 1:53,100,799...53,107,238

G

nuclear factor, erythroid derived 2, like 2

multiple interactions

Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in decreased expression of NFE2L2 mRNA]

PMID:32007421 PMID:35130744

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

nitric oxide synthase 2, inducible

increases expression
multiple interactions

Rosuvastatin Calcium results in increased expression of NOS2 mRNA
Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of NOS2 mRNA]

PMID:21443142 PMID:32007421 PMID:35130744

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

nitric oxide synthase 3, endothelial cell

multiple interactions
increases expression
affects response to substance

Rosuvastatin Calcium inhibits the reaction [CRP protein results in decreased expression of NOS3]; Rosuvastatin Calcium results in increased phosphorylation of and results in increased activity of NOS3 protein
Rosuvastatin Calcium results in increased expression of NOS3 mRNA
NOS3 protein affects the susceptibility to Rosuvastatin Calcium

PMID:12354446 PMID:15681303 PMID:18162361 PMID:21562509

NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472

G

orosomucoid 1

multiple interactions
decreases expression

Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of ORM1 mRNA]

NCBI chr 4:63,262,793...63,266,400
Ensembl chr 4:63,262,797...63,266,400

G

platelet/endothelial cell adhesion molecule 1

multiple interactions

Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PECAM1 protein]

NCBI chr11:106,545,039...106,606,107
Ensembl chr11:106,545,043...106,641,454

G

selectin, platelet

decreases expression

Rosuvastatin Calcium results in decreased expression of SELP mRNA

NCBI chr 1:163,942,833...163,977,595
Ensembl chr 1:163,942,833...163,977,595

G

serine (or cysteine) peptidase inhibitor, clade E, member 2

multiple interactions

Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SERPINE2 protein]; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]

NCBI chr 1:79,772,038...79,836,382
Ensembl chr 1:79,771,914...79,838,897

G

solute carrier organic anion transporter family, member 1a4

multiple interactions
increases uptake
decreases expression
affects transport

Fusidic Acid inhibits the reaction [SLCO1A4 protein results in increased uptake of Rosuvastatin Calcium]
Rosuvastatin Calcium results in decreased expression of SLCO1A4 protein
SLCO1A4 protein affects the transport of Rosuvastatin Calcium

PMID:19833843 PMID:24909372 PMID:26888941

NCBI chr 6:141,751,164...141,802,011
Ensembl chr 6:141,751,166...141,801,925

G

solute carrier organic anion transporter family, member 1a5

multiple interactions
increases uptake

diosmetin inhibits the reaction [SLCO1A2 protein results in increased uptake of Rosuvastatin Calcium]

NCBI chr 6:142,179,953...142,268,707
Ensembl chr 6:142,179,953...142,268,707

G

solute carrier organic anion transporter family, member 1b2

multiple interactions
increases uptake

Fusidic Acid inhibits the reaction [SLCO1B2 protein results in increased uptake of Rosuvastatin Calcium]
SLCO1B3 protein results in increased uptake of Rosuvastatin Calcium
Fusidic Acid inhibits the reaction [SLCO1B3 protein results in increased uptake of Rosuvastatin Calcium]

PMID:26888941 PMID:31299240

NCBI chr 6:141,575,178...141,632,372
Ensembl chr 6:141,575,244...141,632,372

G

solute carrier organic anion transporter family, member 2b1

multiple interactions
increases uptake

Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of Rosuvastatin Calcium]

NCBI chr 7:99,307,011...99,360,547
Ensembl chr 7:99,307,011...99,360,547

G

superoxide dismutase 1, soluble

multiple interactions
increases expression

[[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species

NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217

G

trefoil factor 1

decreases expression

Rosuvastatin Calcium results in decreased expression of TFF1 mRNA

NCBI chr17:31,380,369...31,384,034
Ensembl chr17:31,380,369...31,384,251

G

transforming growth factor, beta 1

multiple interactions
decreases expression

Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TGFB1 protein]; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]
Rosuvastatin Calcium results in decreased expression of TGFB1 mRNA

PMID:15681303 PMID:27097221

NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502

G

tumor necrosis factor

decreases expression
multiple interactions

Rosuvastatin Calcium results in decreased expression of TNF mRNA
Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of TNF protein]

PMID:15681303 PMID:32007421 PMID:35130744

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

troponin I, cardiac 3

multiple interactions

Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of TNNI3 protein]

PMID:32007421 PMID:35130744

NCBI chr 7:4,521,304...4,526,228
Ensembl chr 7:4,521,304...4,527,228

G

vanin 3

decreases expression

Rosuvastatin Calcium results in decreased expression of VNN3P mRNA

NCBI chr10:23,727,360...23,745,741
Ensembl chr10:23,727,360...23,745,741

G

WT1 transcription factor

increases expression

Rosuvastatin Calcium results in increased expression of WT1 mRNA

NCBI chr 2:104,956,874...105,003,959
Ensembl chr 2:104,956,874...105,003,961

sphinganine 1-phosphate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

dihydrosphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; dihydrosphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 protein]; dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 protein]
dihydrosphingosine 1-phosphate results in increased expression of PTGS2 mRNA; dihydrosphingosine 1-phosphate results in increased expression of PTGS2 protein

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

SPNS lysolipid transporter 2, sphingosine-1-phosphate

decreases abundance

SPNS2 protein results in decreased abundance of dihydrosphingosine 1-phosphate

NCBI chr11:72,342,464...72,380,797
Ensembl chr11:72,342,464...72,380,730

sphingosine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

corticotropin releasing hormone

multiple interactions

Sphingosine inhibits the reaction [CRH protein inhibits the reaction [CGB3 protein results in increased chemical synthesis of Cyclic AMP]]

NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560

G

cytochrome P450, family 17, subfamily a, polypeptide 1

increases expression

Sphingosine results in increased expression of CYP17A1 mRNA

NCBI chr19:46,655,604...46,661,439
Ensembl chr19:46,655,604...46,661,611

G

luteinizing hormone beta

multiple interactions

Sphingosine inhibits the reaction [CRH protein inhibits the reaction [CGB3 protein results in increased chemical synthesis of Cyclic AMP]]; Sphingosine inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [CGB3 protein results in increased chemical synthesis of Cyclic AMP]]

NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321

G

tyrosine aminotransferase

multiple interactions

Sphingosine inhibits the reaction [Calcimycin promotes the reaction [Dexamethasone results in increased activity of TAT protein]]; Sphingosine inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Dexamethasone results in increased activity of TAT protein]]; Sphingosine inhibits the reaction [Ursodeoxycholic Acid promotes the reaction [Dexamethasone results in increased activity of TAT protein]]

NCBI chr 8:110,712,710...110,726,436
Ensembl chr 8:110,717,069...110,726,435

G

telomerase reverse transcriptase

affects activity

Sphingosine affects the activity of TERT protein

NCBI chr13:73,775,030...73,797,962
Ensembl chr13:73,775,030...73,797,962

sphingosine 1-phosphate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actin alpha 2, smooth muscle, aorta

multiple interactions
increases expression

sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of ACTA2 mRNA]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of ACTA2 protein]
sphingosine 1-phosphate results in increased expression of ACTA2 mRNA; sphingosine 1-phosphate results in increased expression of ACTA2 protein

NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990

G

thymoma viral proto-oncogene 1

multiple interactions
increases phosphorylation

sphingosine 1-phosphate results in increased phosphorylation of and results in increased activity of AKT1 protein
sphingosine 1-phosphate results in increased phosphorylation of AKT1 protein

PMID:15946935 PMID:16365044

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

autophagy related 5

increases expression
multiple interactions

sphingosine 1-phosphate results in increased expression of ATG5 mRNA; sphingosine 1-phosphate results in increased expression of ATG5 protein
3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of ATG5 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of ATG5 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of ATG5 mRNA]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of ATG5 protein]

NCBI chr10:44,144,325...44,240,295
Ensembl chr10:44,144,354...44,240,287

G

BCL2-associated X protein

decreases expression
multiple interactions

sphingosine 1-phosphate results in decreased expression of BAX mRNA
sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA]

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

B cell leukemia/lymphoma 2

multiple interactions

sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BCL2 mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 protein]

PMID:24399507 PMID:24420784

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

beclin 1, autophagy related

increases expression
multiple interactions

sphingosine 1-phosphate results in increased expression of BECN1 mRNA; sphingosine 1-phosphate results in increased expression of BECN1 protein
sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of BECN1 mRNA]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of BECN1 protein]

NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112

G

caspase 1

multiple interactions

sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of and results in increased cleavage of CASP1 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of CASP1 mRNA]

NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290

G

cellular communication network factor 2

increases expression

sphingosine 1-phosphate results in increased expression of CCN2 mRNA

NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581

G

collagen, type I, alpha 1

increases expression
multiple interactions

sphingosine 1-phosphate results in increased expression of COL1A1 mRNA; sphingosine 1-phosphate results in increased expression of COL1A1 protein
3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of COL1A1 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of COL1A1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [sphingosine 1-phosphate results in increased expression of COL1A1 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of COL1A1 mRNA]

NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868

G

cAMP responsive element binding protein 1

increases phosphorylation
multiple interactions

sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein]

NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707

G

C-X-C motif chemokine ligand 15

multiple interactions
increases expression

1-Butanol inhibits the reaction [sphingosine 1-phosphate results in increased expression of CXCL8 mRNA]; Dactinomycin inhibits the reaction [sphingosine 1-phosphate results in increased expression of CXCL8 mRNA]; Pertussis Toxin inhibits the reaction [sphingosine 1-phosphate results in increased expression of CXCL8 protein]
sphingosine 1-phosphate results in increased expression of CXCL8 mRNA; sphingosine 1-phosphate results in increased expression of CXCL8 protein

PMID:12039947 PMID:19349368

NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926

G

C-X-C motif chemokine receptor 1

decreases expression

sphingosine 1-phosphate results in decreased expression of CXCR1 mRNA

NCBI chr 1:74,228,862...74,233,867
Ensembl chr 1:74,230,944...74,233,790

G

cytochrome P450, family 17, subfamily a, polypeptide 1

increases expression

sphingosine 1-phosphate results in increased expression of CYP17A1 mRNA

NCBI chr19:46,655,604...46,661,439
Ensembl chr19:46,655,604...46,661,611

G

epidermal growth factor receptor

increases phosphorylation
multiple interactions

sphingosine 1-phosphate results in increased phosphorylation of EGFR protein
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of EGFR protein]

NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158

G

fibronectin 1

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; 3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; 3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of and results in increased lipidation of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein; [sphingosine 1-phosphate results in increased activity of S1PR2 protein] which results in increased expression of FN1; Curcumin inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; SB 203580 inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of FN1 protein]

PMID:21998146 PMID:22406263 PMID:37169277

NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359

G

guanine nucleotide binding protein, alpha q polypeptide

multiple interactions
increases expression

Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of GNAQ protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of GNAQ protein]

NCBI chr19:16,110,048...16,365,884
Ensembl chr19:16,110,195...16,364,827

G

glycogen synthase kinase 3 alpha

multiple interactions

sphingosine 1-phosphate inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3A protein]; Wortmannin inhibits the reaction [sphingosine 1-phosphate inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3A protein]]

NCBI chr 7:24,927,683...24,937,276
Ensembl chr 7:24,927,683...24,937,276

G

glycogen synthase kinase 3 beta

multiple interactions

sphingosine 1-phosphate affects the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3B protein]; Wortmannin affects the reaction [sphingosine 1-phosphate affects the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3B protein]]

NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446

G

hepatocyte growth factor

increases expression

sphingosine 1-phosphate results in increased expression of HGF mRNA

NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150

G

harakiri, BCL2 interacting protein (contains only BH3 domain)

multiple interactions

sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HRK mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in increased expression of HRK mRNA]

PMID:24399507 PMID:24420784

NCBI chr 5:118,307,829...118,327,543
Ensembl chr 5:118,302,713...118,327,543

G

heat shock factor 1

increases activity

sphingosine 1-phosphate results in increased activity of HSF1 protein

NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113

G

insulin-like growth factor 1

increases expression

sphingosine 1-phosphate results in increased expression of IGF1 mRNA

NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904

G

interleukin 18

multiple interactions

3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL18 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL18 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL18 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of IL18 protein]

NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140

G

interleukin 1 beta

increases expression
multiple interactions
increases secretion

sphingosine 1-phosphate results in increased expression of IL1B mRNA
Janus Kinase Inhibitors inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]; Janus Kinase Inhibitors inhibits the reaction [sphingosine 1-phosphate results in increased secretion of IL1B protein]; S1PR1 protein affects the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]; STAT3 protein affects the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]; STAT3 protein affects the reaction [sphingosine 1-phosphate results in increased secretion of IL1B protein]

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 6

multiple interactions
increases expression

JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL6 mRNA]

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

Janus kinase 2

increases phosphorylation

sphingosine 1-phosphate results in increased phosphorylation of JAK2 protein

NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480

G

kinase insert domain protein receptor

multiple interactions

sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of KDR mRNA]; sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of KDR mRNA]

NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118

G

laminin, alpha 3

increases expression

sphingosine 1-phosphate results in increased expression of LAMA3 mRNA

NCBI chr18:12,466,806...12,716,070
Ensembl chr18:12,466,876...12,716,070

G

laminin, beta 3

increases expression

sphingosine 1-phosphate results in increased expression of LAMB3 mRNA

NCBI chr 1:192,976,661...193,026,186
Ensembl chr 1:192,890,007...193,026,186

G

laminin, gamma 2

increases expression

sphingosine 1-phosphate results in increased expression of LAMC2 mRNA

NCBI chr 1:152,998,502...153,062,193
Ensembl chr 1:152,998,502...153,062,193

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions
increases expression

JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of and results in increased lipidation of MAP1LC3B protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of MAP1LC3B mRNA]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased phosphorylation of and results in increased lipidation of MAP1LC3B protein]; sphingosine 1-phosphate results in increased phosphorylation of and results in increased lipidation of MAP1LC3B protein
sphingosine 1-phosphate results in increased expression of MAP1LC3B mRNA

NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499

G

mitogen-activated protein kinase 1

multiple interactions
increases phosphorylation

JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein]; Plant Extracts inhibits the reaction [sphingosine 1-phosphate results in increased activity of and results in increased phosphorylation of MAPK1 protein]; sphingosine 1-phosphate results in increased phosphorylation of and results in increased activity of MAPK1 protein; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK1 protein modified form]; [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK1 protein modified form

PMID:16365044 PMID:18612546 PMID:22251058 PMID:22406263 PMID:26518876

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

multiple interactions
increases phosphorylation

JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]; Plant Extracts inhibits the reaction [sphingosine 1-phosphate results in increased activity of and results in increased phosphorylation of MAPK3 protein]; sphingosine 1-phosphate results in increased phosphorylation of and results in increased activity of MAPK3 protein; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK3 protein modified form]; [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK3 protein modified form

PMID:16365044 PMID:18612546 PMID:22251058 PMID:22406263 PMID:26518876

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

matrix metallopeptidase 2

multiple interactions
increases expression

JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP2 mRNA]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP2 protein]
sphingosine 1-phosphate results in increased expression of MMP2 mRNA; sphingosine 1-phosphate results in increased expression of MMP2 protein

NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048

G

matrix metallopeptidase 9

multiple interactions
increases expression

Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein]
sphingosine 1-phosphate results in increased expression of MMP9 mRNA; sphingosine 1-phosphate results in increased expression of MMP9 protein

PMID:25980589 PMID:26518876

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

G

NLR family, pyrin domain containing 3

multiple interactions

3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of NLRP3 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of NLRP3 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [sphingosine 1-phosphate results in increased expression of NLRP3 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of NLRP3 mRNA]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of NLRP3 protein]

NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782

G

neuropilin 1

multiple interactions

sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP1 mRNA]; sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP1 mRNA]

NCBI chr 8:129,085,553...129,231,957
Ensembl chr 8:129,085,085...129,229,844

G

neuropilin 2

multiple interactions

sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP2 mRNA]; sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP2 mRNA]

NCBI chr 1:62,742,476...62,857,851
Ensembl chr 1:62,742,444...62,857,854

G

platelet/endothelial cell adhesion molecule 1

increases expression

sphingosine 1-phosphate results in increased expression of PECAM1 protein

NCBI chr11:106,545,039...106,606,107
Ensembl chr11:106,545,043...106,641,454

G

phospholipase C, beta 4

increases expression
multiple interactions

sphingosine 1-phosphate results in increased expression of PLCB4 protein
Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of PLCB4 protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of PLCB4 protein]

NCBI chr 2:135,500,523...135,856,522
Ensembl chr 2:135,500,931...135,856,513

G

peroxisome proliferator activated receptor alpha

multiple interactions

[Bezafibrate results in increased activity of PPARA protein] which results in decreased abundance of sphingosine 1-phosphate

NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; JTE 013 inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; JTE 013 promotes the reaction [Suramin inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; MK 2206 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; S1PR2 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; S1PR3 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 protein]; sphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; Suramin inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; Suramin promotes the reaction [JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]
sphingosine 1-phosphate results in increased expression of PTGS2 mRNA; sphingosine 1-phosphate results in increased expression of PTGS2 protein

PMID:18612546 PMID:26518876

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions
affects localization

JTE 013 inhibits the reaction [sphingosine 1-phosphate affects the localization of RELA protein modified form]

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

sphingosine-1-phosphate receptor 1

increases response to substance
affects binding
multiple interactions
increases expression

S1PR1 protein results in increased susceptibility to sphingosine 1-phosphate
S1PR1 protein binds to sphingosine 1-phosphate
S1PR1 protein affects the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]
sphingosine 1-phosphate results in increased expression of S1PR1 mRNA
sphingosine 1-phosphate binds to and results in increased activity of S1PR1 protein

PMID:20844107 PMID:24399507 PMID:32401414 PMID:35412894

NCBI chr 3:115,504,082...115,508,704
Ensembl chr 3:115,504,082...115,508,721

G

sphingosine-1-phosphate receptor 2

multiple interactions
increases expression
increases uptake
increases activity

S1PR2 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]
sphingosine 1-phosphate results in increased expression of S1PR2 protein
sphingosine 1-phosphate results in increased uptake of S1PR2 protein
sphingosine 1-phosphate results in increased activity of S1PR2 protein
[JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] results in decreased susceptibility to [sphingosine 1-phosphate co-treated with Glucose]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] which results in decreased susceptibility to sphingosine 1-phosphate; [sphingosine 1-phosphate results in increased activity of S1PR2 protein] which results in increased expression of FN1; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR2 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of S1PR2 protein]

PMID:18612546 PMID:22406263 PMID:26518876 PMID:37169277

NCBI chr 9:20,877,248...20,888,089
Ensembl chr 9:20,873,657...20,888,077

G

sphingosine-1-phosphate receptor 3

multiple interactions
increases expression

Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR3 protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR3 protein]; S1PR3 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]

PMID:18612546 PMID:25980589

NCBI chr13:51,562,654...51,576,833
Ensembl chr13:51,562,675...51,576,833

G

sphingosine-1-phosphate receptor 5

multiple interactions

Endocannabinoids inhibits the reaction [sphingosine 1-phosphate binds to and results in increased activity of S1PR5 protein]; sphingosine 1-phosphate binds to and results in increased activity of S1PR5 protein

NCBI chr 9:21,154,213...21,159,739
Ensembl chr 9:21,154,208...21,159,739

G

SMAD family member 3

increases phosphorylation

sphingosine 1-phosphate results in increased phosphorylation of SMAD3 protein

NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276

G

sphingomyelin phosphodiesterase 2, neutral

multiple interactions

sphingosine 1-phosphate inhibits the reaction [Thalidomide results in increased activity of SMPD2 protein]

NCBI chr10:41,363,168...41,366,410
Ensembl chr10:41,361,638...41,366,365

G

sphingosine kinase 1

increases chemical synthesis
multiple interactions

SPHK1 protein results in increased chemical synthesis of sphingosine 1-phosphate
[resveratrol affects the localization of and results in decreased activity of SPHK1 protein] which results in decreased abundance of sphingosine 1-phosphate; sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SPHK1 mRNA]; sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SPHK1 protein]

PMID:22251058 PMID:24399507 PMID:26045781

NCBI chr11:116,421,662...116,427,502
Ensembl chr11:116,421,751...116,427,501

G

SPNS lysolipid transporter 2, sphingosine-1-phosphate

increases secretion
multiple interactions

SPNS2 protein results in increased secretion of sphingosine 1-phosphate
TGFB2 protein promotes the reaction [SPNS2 protein results in increased secretion of sphingosine 1-phosphate]

NCBI chr11:72,342,464...72,380,797
Ensembl chr11:72,342,464...72,380,730

G

sequestosome 1

decreases expression

sphingosine 1-phosphate results in decreased expression of SQSTM1 protein

NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654

G

signal transducer and activator of transcription 3

multiple interactions
increases phosphorylation

Janus Kinase Inhibitors inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of STAT3 protein]; STAT3 protein affects the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]; STAT3 protein affects the reaction [sphingosine 1-phosphate results in increased secretion of IL1B protein]

NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366

G

transforming growth factor, beta 2

multiple interactions

TGFB2 protein promotes the reaction [SPNS2 protein results in increased secretion of sphingosine 1-phosphate]

NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186

G

tumor necrosis factor

multiple interactions
increases expression

JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of TNF mRNA]; sphingosine 1-phosphate inhibits the reaction [TNF results in increased expression of VCAM1]

PMID:18981156 PMID:26518876

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

vascular cell adhesion molecule 1

multiple interactions

sphingosine 1-phosphate inhibits the reaction [TNF results in increased expression of VCAM1]

NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	22194
chemical entity	22193
atom	22186
nonmetal atom	22071
nitrogen atom	20022
nitrogen molecular entity	20022
organonitrogen compound	19826
sphingolipid	219
(+)-Prosopinine	0
1-O-(alpha-D-galactopyranosyl)-N-hexacosanoyl-D-xylo-phytosphingosine	0
L-erythro-N-acylsphingosine +	0
L-erythro-N-dodecanoylsphingosine	0
N-acyl-3-ketodihydrosphingosine +	0
Sphingosine 1-phosphate (d19:1-P)	0
ceramide +	127
glycosphingolipid +	41
hexadecasphinganine-based sphingolipid	0
hexadecasphingosine-based sphingolipid	0
phosphonosphingolipid +	0
phosphosphingolipid +	100
sphinganine-based sphingolipid +	7
sphingoid +	197
sphingosine-based sphingolipid +	92
Path 2
Term	Annotations
CHEBI ontology	22194
subatomic particle	22186
composite particle	22186
hadron	22186
baryon	22186
nucleon	22186
atomic nucleus	22186
atom	22186
main group element atom	22120
p-block element atom	22120
carbon group element atom	21920
carbon atom	21846
organic molecular entity	21846
heteroorganic entity	21500
organochalcogen compound	20983
organooxygen compound	20824
sphingolipid	219
(+)-Prosopinine	0
1-O-(alpha-D-galactopyranosyl)-N-hexacosanoyl-D-xylo-phytosphingosine	0
L-erythro-N-acylsphingosine +	0
L-erythro-N-dodecanoylsphingosine	0
N-acyl-3-ketodihydrosphingosine +	0
Sphingosine 1-phosphate (d19:1-P)	0
ceramide +	127
glycosphingolipid +	41
hexadecasphinganine-based sphingolipid	0
hexadecasphingosine-based sphingolipid	0
phosphonosphingolipid +	0
phosphosphingolipid +	100
sphinganine-based sphingolipid +	7
sphingoid +	197
sphingosine-based sphingolipid +	92

paths to the root