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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sphingolipid
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Accession:CHEBI:26739 term browser browse the term
Definition:Sphingolipids are a complex family of compounds that share a common structural feature, a sphingoid base backbone.
Synonyms:related_synonym: sphingolipids


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1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO KRN 7000 results in increased expression of CXCL10 protein CTD PMID:15867097 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Il12b interleukin 12B increases expression ISO KRN 7000 results in increased expression of IL12B protein CTD PMID:15867097 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases chemical synthesis
ISO Cyclosporine inhibits the reaction [ABCB1 protein results in increased chemical synthesis of globotriaosylceramide]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased chemical synthesis of globotriaosylceramide] CTD PMID:14662772 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Curcumin inhibits the reaction [IL1B protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]]; IL1B protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]; TNF protein promotes the reaction [IL1B protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]] CTD PMID:16819191 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Curcumin inhibits the reaction [TNF protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]]; TNF protein promotes the reaction [IL1B protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]]; TNF protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide] CTD PMID:16819191 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
alpha-galactosylceramide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata3 GATA binding protein 3 multiple interactions ISO [Ovalbumin co-treated with alpha-galactosylceramide] results in decreased expression of GATA3 mRNA CTD PMID:30803854 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [Floxacillin co-treated with alpha-galactosylceramide] results in increased expression of GPT protein CTD PMID:30993380 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Ifng interferon gamma multiple interactions
increases secretion
ISO [Alcohols co-treated with alpha-galactosylceramide] results in increased expression of IFNG protein; [Ovalbumin co-treated with alpha-galactosylceramide] results in increased secretion of IFNG protein
alpha-galactosylceramide results in increased secretion of IFNG protein
CTD PMID:12482940, PMID:25499027, PMID:30803854 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Ovalbumin co-treated with alpha-galactosylceramide] results in decreased secretion of IL10 protein CTD PMID:30803854 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il13 interleukin 13 multiple interactions ISO [Ovalbumin co-treated with alpha-galactosylceramide] results in decreased secretion of IL13 protein CTD PMID:30803854 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il17a interleukin 17A multiple interactions ISO [Ovalbumin co-treated with alpha-galactosylceramide] results in decreased secretion of IL17A protein CTD PMID:30803854 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il4 interleukin 4 increases secretion
multiple interactions
ISO alpha-galactosylceramide results in increased secretion of IL4 protein
[Ovalbumin co-treated with alpha-galactosylceramide] results in decreased secretion of IL4 protein
CTD PMID:12482940, PMID:30803854 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 multiple interactions ISO [Ovalbumin co-treated with alpha-galactosylceramide] results in decreased secretion of IL5 protein CTD PMID:30803854 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Rorc RAR-related orphan receptor C multiple interactions ISO [Ovalbumin co-treated with alpha-galactosylceramide] results in decreased expression of RORC mRNA alternative form CTD PMID:30803854 NCBI chr 2:195,612,471...195,636,797
Ensembl chr 2:195,617,021...195,637,630
JBrowse link
G Tbx21 T-box transcription factor 21 multiple interactions ISO [Ovalbumin co-treated with alpha-galactosylceramide] results in increased expression of TBX21 mRNA CTD PMID:30803854 NCBI chr10:85,032,799...85,049,331
Ensembl chr10:85,032,799...85,049,331
JBrowse link
beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nos2 nitric oxide synthase 2 multiple interactions ISO ganglioside, GD1b analog inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; ganglioside, GD1b inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites] CTD PMID:31202640 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
ceramide 1-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cerk ceramide kinase affects abundance ISO CERK protein affects the abundance of ceramide 1-phosphate CTD PMID:15899891 NCBI chr 7:127,015,162...127,058,056
Ensembl chr 7:127,015,162...127,058,056
JBrowse link
ganglioside GM1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd14 CD14 molecule multiple interactions EXP CD14 protein affects the reaction [G(M1) Ganglioside results in increased secretion of Nitric Oxide] CTD PMID:16651628 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP G(M1) Ganglioside results in increased expression of CDKN1A protein CTD PMID:15654767 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression EXP G(M1) Ganglioside results in decreased expression of CDKN1B protein CTD PMID:15654767 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 affects localization ISO NPC1 affects the localization of G(M1) Ganglioside CTD PMID:12183525 NCBI chr18:3,616,878...3,662,656
Ensembl chr18:3,616,878...3,662,683
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 multiple interactions EXP G(M1) Ganglioside inhibits the reaction [Methylmercury Compounds results in decreased phosphorylation of NTRK1 protein]; G(M1) Ganglioside inhibits the reaction [staurosporine aglycone results in decreased phosphorylation of NTRK1 protein] CTD PMID:25545984 NCBI chr 2:187,143,568...187,160,373
Ensembl chr 2:187,143,568...187,160,373
JBrowse link
G Pld1 phospholipase D1 multiple interactions EXP PLD1 protein affects the reaction [dinitrophenyl-bovine serum albumin affects the localization of G(M1) Ganglioside] CTD PMID:19794068 NCBI chr 2:113,651,967...113,849,403
Ensembl chr 2:113,652,348...113,849,403
JBrowse link
G Pld2 phospholipase D2 multiple interactions EXP PLD2 protein affects the reaction [dinitrophenyl-bovine serum albumin affects the localization of G(M1) Ganglioside] CTD PMID:19794068 NCBI chr10:57,161,921...57,181,148
Ensembl chr10:57,163,174...57,179,730
JBrowse link
G Slc18a2 solute carrier family 18 member A2 increases expression EXP G(M1) Ganglioside results in increased expression of SLC18A2 mRNA CTD PMID:14552908 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148
JBrowse link
G Slc6a3 solute carrier family 6 member 3 increases expression EXP G(M1) Ganglioside results in increased expression of SLC6A3 mRNA CTD PMID:14552908 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Th tyrosine hydroxylase increases activity EXP G(M1) Ganglioside results in increased activity of TH protein CTD PMID:14552908 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tlr4 toll-like receptor 4 decreases expression EXP G(M1) Ganglioside results in decreased expression of TLR4 protein CTD PMID:16651628 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
myriocin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO thermozymocidin inhibits the reaction [Dexamethasone results in increased expression of ACACA mRNA] CTD PMID:31053639 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Angptl4 angiopoietin-like 4 increases expression ISO thermozymocidin results in increased expression of ANGPTL4 mRNA CTD PMID:31053639 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079
JBrowse link
G Casp3 caspase 3 multiple interactions ISO thermozymocidin inhibits the reaction [Dronabinol results in increased activity of CASP3 protein]; thermozymocidin inhibits the reaction [gamma-Tocopherol results in increased activity of CASP3 protein] CTD PMID:15596715, PMID:16818650 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO thermozymocidin inhibits the reaction [resveratrol results in increased expression of DDIT3 protein] CTD PMID:24264887 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO thermozymocidin inhibits the reaction [[sorafenib co-treated with vorinostat] affects the localization of and results in increased activity of FAS protein] CTD PMID:18787411 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [thermozymocidin results in increased susceptibility to Dexamethasone] which results in decreased expression of FASN mRNA CTD PMID:31053639 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator multiple interactions ISO
EXP
thermozymocidin inhibits the reaction [Dronabinol results in increased expression of NUPR1 mRNA] CTD PMID:16616335, PMID:16818650 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions ISO thermozymocidin inhibits the reaction [resveratrol results in decreased activity of ODC1 protein] CTD PMID:17521618 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO thermozymocidin inhibits the reaction [resveratrol results in increased cleavage of PARP1 protein] CTD PMID:24264887 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Prkcz protein kinase C, zeta decreases activity ISO thermozymocidin results in decreased activity of PRKCZ protein CTD PMID:31053639 NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421
JBrowse link
N,N-dimethylsphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions ISO [Bortezomib co-treated with N,N-dimethylsphingosine] results in decreased expression of ABL1 protein CTD PMID:21195056 NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388
JBrowse link
G Asah2 N-acylsphingosine amidohydrolase 2 multiple interactions ISO N,N-dimethylsphingosine inhibits the reaction [ASAH2 protein results in increased expression of BCL2 protein] CTD PMID:15498114 NCBI chr 1:250,557,042...250,665,083
Ensembl chr 1:250,557,044...250,630,677
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO N,N-dimethylsphingosine inhibits the reaction [ASAH2 protein results in increased expression of BCL2 protein] CTD PMID:15498114 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G C5 complement C5 multiple interactions ISO N,N-dimethylsphingosine inhibits the reaction [C5 protein results in increased activity of RELA protein] CTD PMID:19284563 NCBI chr 3:14,049,993...14,113,931
NCBI chr 3:14,206,466...14,229,141
Ensembl chr 3:14,049,995...14,229,080
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Bortezomib co-treated with N,N-dimethylsphingosine] results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:21195056 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP N,N-dimethylsphingosine inhibits the reaction [Glucose results in increased expression of FN1 protein] CTD PMID:21998146 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions ISO [Bortezomib co-treated with N,N-dimethylsphingosine] results in decreased expression of MCL1 protein CTD PMID:21195056 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [Bortezomib co-treated with N,N-dimethylsphingosine] results in increased cleavage of PARP1 protein CTD PMID:21195056 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO N,N-dimethylsphingosine inhibits the reaction [C5 protein results in increased activity of RELA protein] CTD PMID:19284563 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sphk1 sphingosine kinase 1 decreases activity
decreases expression
multiple interactions
ISO
EXP
N,N-dimethylsphingosine results in decreased activity of SPHK1 protein
N,N-dimethylsphingosine results in decreased expression of SPHK1 protein
N,N-dimethylsphingosine inhibits the reaction [Glucose results in increased activity of SPHK1 protein]
CTD PMID:17065523, PMID:19284563, PMID:21195056, PMID:21998146 NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393
JBrowse link
N-\{6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl\}sphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport ISO ABCB1 protein results in increased transport of N-(7-(4-nitrobenzo-2-oxa-1,3-diazole))-6-aminocaproyl sphingosine CTD PMID:21436125 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
N-acetylsphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO N-acetylsphingosine results in increased expression of ABCB1 CTD PMID:11573427 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO BCL2 protein inhibits the reaction [N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; N-acetylsphingosine inhibits the reaction [CAV1 protein results in increased phosphorylation of AKT1 protein]; N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of AKT1 protein
N-acetylsphingosine results in decreased phosphorylation of AKT1 protein
CTD PMID:12640124, PMID:16215670, PMID:21821001 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bad BCL2-associated agonist of cell death decreases phosphorylation
multiple interactions
ISO N-acetylsphingosine results in decreased phosphorylation of BAD protein
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in decreased phosphorylation of BAD protein]
CTD PMID:24420784 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO N-acetylsphingosine results in increased expression of BAX mRNA CTD PMID:24420784 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO BCL2 protein inhibits the reaction [N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased cleavage of and results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased degradation of PLCG1 protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 mRNA]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 protein]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 protein]
N-acetylsphingosine results in decreased expression of BCL2 mRNA; N-acetylsphingosine results in decreased expression of BCL2 protein
CTD PMID:9295281, PMID:16215670, PMID:24420784 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases degradation
ISO LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of BCL2L1 protein] CTD PMID:21821001 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased cleavage of and results in increased activity of CASP3 protein]; N-acetylsphingosine results in increased cleavage of and results in increased activity of CASP3 protein
N-acetylsphingosine results in increased activity of CASP3 protein
CTD PMID:10919278, PMID:16215670, PMID:21259059 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cav1 caveolin 1 multiple interactions ISO N-acetylsphingosine inhibits the reaction [CAV1 protein results in increased phosphorylation of AKT1 protein] CTD PMID:12640124 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions
decreases localization
EXP benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [N-acetylsphingosine results in decreased localization of CEBPB protein]; N-acetylsphingosine inhibits the reaction [oltipraz results in increased localization of CEBPB protein] CTD PMID:15319326 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cftr CF transmembrane conductance regulator increases activity ISO N-acetylsphingosine results in increased activity of CFTR protein CTD PMID:15474513 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Clk1 CDC-like kinase 1 increases expression ISO N-acetylsphingosine results in increased expression of CLK1 mRNA CTD PMID:18270325 NCBI chr 9:65,296,777...65,308,017
Ensembl chr 9:65,296,778...65,307,995
JBrowse link
G Ctsd cathepsin D increases secretion EXP N-acetylsphingosine results in increased secretion of CTSD protein CTD PMID:15040013 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Dapk1 death associated protein kinase 1 increases activity ISO
EXP
N-acetylsphingosine results in increased activity of DAPK1 protein CTD PMID:17087515 NCBI chr17:4,297,038...4,454,941
Ensembl chr17:4,297,224...4,454,778
JBrowse link
G Dffb DNA fragmentation factor subunit beta increases activity EXP N-acetylsphingosine results in increased activity of DFFB protein CTD PMID:15040013 NCBI chr 5:171,250,559...171,261,875
Ensembl chr 5:171,249,633...171,262,119
JBrowse link
G Dnm1l dynamin 1-like increases expression EXP N-acetylsphingosine results in increased expression of DNM1L protein CTD PMID:18006463 NCBI chr11:88,830,968...88,882,271
Ensembl chr11:88,830,957...88,880,198
JBrowse link
G Egf epidermal growth factor multiple interactions ISO N-acetylsphingosine inhibits the reaction [EGF protein results in increased abundance of Diglycerides] CTD PMID:11082532 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions
increases expression
ISO N-acetylsphingosine promotes the reaction [IL1B protein results in increased expression of F3 protein]
N-acetylsphingosine results in increased expression of F3 protein
CTD PMID:27556861 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fis1 fission, mitochondrial 1 increases expression EXP N-acetylsphingosine results in increased expression of FIS1 protein CTD PMID:18006463 NCBI chr12:22,750,485...22,765,324
Ensembl chr12:22,750,485...22,765,308
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha decreases phosphorylation ISO N-acetylsphingosine results in decreased phosphorylation of GSK3A protein CTD PMID:21821001 NCBI chr 1:82,097,244...82,108,238
Ensembl chr 1:82,097,247...82,108,203
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation
decreases expression
multiple interactions
ISO N-acetylsphingosine results in decreased phosphorylation of GSK3B protein
N-acetylsphingosine results in decreased expression of GSK3B protein modified form
GSK3B mutant form inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein]
CTD PMID:21821001, PMID:24420784 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions
decreases expression
EXP N-acetylsphingosine inhibits the reaction [2-tert-butylhydroquinone results in increased expression of GSTA2 protein]; N-acetylsphingosine inhibits the reaction [oltipraz results in increased expression of GSTA2 protein]
N-acetylsphingosine results in decreased expression of GSTA2 protein
CTD PMID:15155840, PMID:15319326 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta3 glutathione S-transferase alpha 3 decreases expression EXP N-acetylsphingosine results in decreased expression of GSTA3 protein CTD PMID:15155840 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 decreases expression EXP N-acetylsphingosine results in decreased expression of GSTA5 protein CTD PMID:15155840 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression ISO N-acetylsphingosine results in decreased expression of HMOX1 mRNA CTD PMID:18270325 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnf1a HNF1 homeobox A multiple interactions
decreases ubiquitination
EXP N-acetylsphingosine results in decreased expression of and results in decreased activity of HNF1A protein
N-acetylsphingosine results in decreased ubiquitination of HNF1A protein
CTD PMID:15155840 NCBI chr12:47,407,811...47,433,342
Ensembl chr12:47,407,811...47,433,342
JBrowse link
G Hrk harakiri, BCL2 interacting protein increases expression
multiple interactions
ISO N-acetylsphingosine results in increased expression of HRK mRNA
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in increased expression of HRK mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in increased expression of HRK mRNA]
CTD PMID:24420784 NCBI chr12:44,008,879...44,029,211 JBrowse link
G Id2 inhibitor of DNA binding 2 decreases expression ISO N-acetylsphingosine results in decreased expression of ID2 mRNA CTD PMID:18270325 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
JBrowse link
G Il16 interleukin 16 increases expression ISO N-acetylsphingosine results in increased expression of IL16 mRNA CTD PMID:18270325 NCBI chr 1:145,781,923...145,881,538
Ensembl chr 1:145,781,928...145,870,912
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO N-acetylsphingosine promotes the reaction [IL1B protein results in increased expression of F3 protein] CTD PMID:27556861 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of KDR protein
sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of KDR mRNA]
CTD PMID:15313899, PMID:15741222 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Klf6 Kruppel-like factor 6 increases expression ISO N-acetylsphingosine results in increased expression of KLF6 mRNA CTD PMID:18270325 NCBI chr17:67,887,939...67,945,052
Ensembl chr17:67,887,939...67,945,037
JBrowse link
G Lgals3 galectin 3 multiple interactions
increases expression
decreases response to substance
ISO 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein]; GSK3B mutant form inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein]; LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of BCL2L1 protein]; LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of MCL1 protein]
LGALS3 results in decreased susceptibility to N-acetylsphingosine
CTD PMID:21821001 NCBI chr15:24,153,602...24,165,537
Ensembl chr15:24,141,651...24,165,537
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO N-acetylsphingosine affects the phosphorylation of and results in increased activity of MAP3K5 protein; TXNIP affects the reaction [N-acetylsphingosine affects the phosphorylation of and results in increased activity of MAP3K5 protein] CTD PMID:18270325 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity EXP N-acetylsphingosine results in increased activity of MAPK1 protein CTD PMID:10700234 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases activity EXP N-acetylsphingosine results in increased activity of MAPK3 protein CTD PMID:10700234 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO N-acetylsphingosine results in increased phosphorylation of and results in increased activity of MAPK9 protein; TXNIP affects the reaction [N-acetylsphingosine results in increased phosphorylation of and results in increased activity of MAPK9 protein] CTD PMID:18270325 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
increases degradation
ISO LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of MCL1 protein] CTD PMID:21821001 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression ISO N-acetylsphingosine results in decreased expression of MDM2 mRNA; N-acetylsphingosine results in decreased expression of MDM2 protein CTD PMID:18206046 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mfn2 mitofusin 2 decreases response to substance EXP MFN2 protein results in decreased susceptibility to N-acetylsphingosine CTD PMID:18006463 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Mir15b microRNA 15b decreases expression ISO N-acetylsphingosine results in decreased expression of MIR15B mRNA CTD PMID:20145152 NCBI chr 2:165,605,923...165,606,020
Ensembl chr 2:165,605,923...165,606,020
JBrowse link
G Mir20a microRNA 20a decreases expression ISO N-acetylsphingosine results in decreased expression of MIR20A mRNA CTD PMID:20145152 NCBI chr15:100,180,334...100,180,418
Ensembl chr15:100,180,334...100,180,418
JBrowse link
G Mir25 microRNA 25 decreases expression ISO N-acetylsphingosine results in decreased expression of MIR25 mRNA CTD PMID:20145152 NCBI chr12:19,307,340...19,307,423
Ensembl chr12:19,307,340...19,307,423
JBrowse link
G Mir93 microRNA 93 decreases expression ISO N-acetylsphingosine results in decreased expression of MIR93 mRNA CTD PMID:20145152 NCBI chr12:19,307,543...19,307,629
Ensembl chr12:19,307,543...19,307,629
JBrowse link
G Mirlet7b microRNA let-7b decreases expression ISO N-acetylsphingosine results in decreased expression of MIRLET7B mRNA CTD PMID:20145152 NCBI chr 7:126,590,627...126,590,711
Ensembl chr 7:126,590,627...126,590,711
JBrowse link
G Mirlet7d microRNA let-7d decreases expression ISO N-acetylsphingosine results in decreased expression of MIRLET7D mRNA CTD PMID:20145152 NCBI chr17:16,419,980...16,420,077
Ensembl chr17:16,419,980...16,420,077
JBrowse link
G Mirlet7i microRNA let-7i decreases expression ISO N-acetylsphingosine results in decreased expression of MIRLET7I mRNA CTD PMID:20145152 NCBI chr 7:66,802,731...66,802,815
Ensembl chr 7:66,802,732...66,802,821
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
decreases localization
EXP benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [N-acetylsphingosine results in decreased localization of NFE2L2 protein]; N-acetylsphingosine inhibits the reaction [2-tert-butylhydroquinone results in increased localization of NFE2L2 protein] CTD PMID:15319326 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Ngf nerve growth factor multiple interactions EXP N-acetylsphingosine affects the reaction [Glutathione affects the activity of NGF protein] CTD PMID:12381813 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nrp1 neuropilin 1 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP1 mRNA] CTD PMID:15741222 NCBI chr19:61,332,351...61,486,166
Ensembl chr19:61,332,351...61,485,858
JBrowse link
G Nrp2 neuropilin 2 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP2 mRNA] CTD PMID:15741222 NCBI chr 9:69,496,875...69,609,802
Ensembl chr 9:69,497,121...69,612,087
JBrowse link
G Odc1 ornithine decarboxylase 1 decreases activity ISO N-acetylsphingosine results in decreased activity of ODC1 protein CTD PMID:17521618 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases activity ISO N-acetylsphingosine results in increased activity of PARP1 protein CTD PMID:24420784 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pink1 PTEN induced kinase 1 decreases response to substance ISO PINK1 protein results in decreased susceptibility to N-acetylsphingosine CTD PMID:24792327 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415
JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO [N-acetylsphingosine results in increased abundance of Ceramides] which results in increased secretion of PLAT protein CTD PMID:11107162 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions
increases degradation
ISO BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased degradation of PLCG1 protein] CTD PMID:16215670 NCBI chr 3:156,727,642...156,758,307
Ensembl chr 3:156,727,642...156,758,307
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase increases activity EXP N-acetylsphingosine results in increased activity of RAF1 protein CTD PMID:10700234 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects activity ISO N-acetylsphingosine affects the activity of RELA protein CTD PMID:12853972 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rhob ras homolog family member B increases expression ISO N-acetylsphingosine results in increased expression of RHOB mRNA CTD PMID:18270325 NCBI chr 6:33,689,127...33,691,301
Ensembl chr 6:33,689,127...33,691,301
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [N-acetylsphingosine results in increased abundance of Ceramides] which results in decreased secretion of SERPINE1 protein CTD PMID:11107162 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions
ISO
EXP
N-acetylsphingosine results in increased expression of SOD2 mRNA; N-acetylsphingosine results in increased expression of SOD2 protein
Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of SOD2 protein]
CTD PMID:9535218, PMID:10428046 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sts steroid sulfatase multiple interactions ISO N-acetylsphingosine inhibits the reaction [Tretinoin results in increased activity of STS protein] CTD PMID:16178010 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750
JBrowse link
G Tfe3 transcription factor binding to IGHM enhancer 3 multiple interactions ISO N-acetylsphingosine results in decreased phosphorylation of and affects the localization of TFE3 protein CTD PMID:29945972 NCBI chr  X:15,574,579...15,587,826
Ensembl chr  X:15,575,934...15,587,419
JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 increases expression ISO N-acetylsphingosine results in increased expression of TGIF1 mRNA CTD PMID:18270325 NCBI chr 9:119,181,079...119,190,698
Ensembl chr 9:119,181,083...119,190,698
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of TP53 mRNA]; Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of TP53 protein]
N-acetylsphingosine results in increased expression of TP53 mRNA; N-acetylsphingosine results in increased expression of TP53 protein
CTD PMID:9535218 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Txn1 thioredoxin 1 decreases activity
multiple interactions
ISO N-acetylsphingosine results in decreased activity of TXN protein
TXNIP affects the reaction [N-acetylsphingosine results in decreased activity of TXN protein]
CTD PMID:18270325 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Txnip thioredoxin interacting protein increases expression
multiple interactions
ISO N-acetylsphingosine results in increased expression of TXNIP protein
N-acetylsphingosine results in increased expression of TXNIP mRNA; N-acetylsphingosine results in increased expression of TXNIP protein
TXNIP affects the reaction [N-acetylsphingosine affects the phosphorylation of and results in increased activity of MAP3K5 protein]; TXNIP affects the reaction [N-acetylsphingosine results in decreased activity of TXN protein]; TXNIP affects the reaction [N-acetylsphingosine results in increased phosphorylation of and results in increased activity of MAPK9 protein]
CTD PMID:18270325 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO N-acetylsphingosine results in decreased expression of and results in decreased secretion of VEGFA protein CTD PMID:15313899 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
N-acylsphinganine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases cleavage ISO dihydroceramide metabolite results in increased cleavage of CASP3 protein CTD PMID:17586710 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp6 caspase 6 increases cleavage ISO dihydroceramide metabolite results in increased cleavage of CASP6 protein CTD PMID:17586710 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp9 caspase 9 increases cleavage ISO dihydroceramide metabolite results in increased cleavage of CASP9 protein CTD PMID:17586710 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
N-hexadecanoylsphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asah2 N-acylsphingosine amidohydrolase 2 multiple interactions ISO ASAH2 protein inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine] CTD PMID:15946935 NCBI chr 1:250,557,042...250,665,083
Ensembl chr 1:250,557,044...250,630,677
JBrowse link
G Atf4 activating transcription factor 4 increases expression
multiple interactions
ISO N-palmitoylsphingosine results in increased expression of ATF4 mRNA
tauroursodeoxycholic acid inhibits the reaction [N-palmitoylsphingosine results in increased expression of ATF4 mRNA]
CTD PMID:28223344 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atf6 activating transcription factor 6 increases expression
multiple interactions
ISO N-palmitoylsphingosine results in increased expression of ATF6 mRNA
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ATF6 mRNA; tauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ATF6 mRNA]; tauroursodeoxycholic acid inhibits the reaction [N-palmitoylsphingosine results in increased expression of ATF6 mRNA]
CTD PMID:28223344 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Cs citrate synthase decreases expression
multiple interactions
ISO N-palmitoylsphingosine results in decreased expression of CS mRNA
[N-palmitoylsphingosine co-treated with Dietary Fats] results in decreased activity of CS protein; tauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in decreased activity of CS protein]; tauroursodeoxycholic acid inhibits the reaction [N-palmitoylsphingosine results in decreased expression of CS mRNA]
CTD PMID:28223344 NCBI chr 7:2,752,680...2,778,963
Ensembl chr 7:2,752,680...2,778,963
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of DDIT3 mRNA; tauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of DDIT3 mRNA]; tauroursodeoxycholic acid inhibits the reaction [N-palmitoylsphingosine results in increased expression of DDIT3 mRNA] CTD PMID:28223344 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
ISO [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of HSPA5 mRNA; tauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of HSPA5 mRNA]; tauroursodeoxycholic acid inhibits the reaction [N-palmitoylsphingosine results in increased expression of HSPA5 mRNA] CTD PMID:28223344 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases abundance
ISO Win 55212-2 inhibits the reaction [IL1B protein results in increased abundance of N-palmitoylsphingosine] CTD PMID:27556861 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 multiple interactions
increases expression
ISO [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR1 mRNA; tauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR1 mRNA]; tauroursodeoxycholic acid inhibits the reaction [N-palmitoylsphingosine results in increased expression of ITPR1 mRNA] CTD PMID:28223344 NCBI chr 4:140,247,297...140,580,749
Ensembl chr 4:140,247,313...140,580,748
JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 increases expression
multiple interactions
ISO N-palmitoylsphingosine results in increased expression of ITPR2 mRNA
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR2 mRNA; tauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR2 mRNA]; tauroursodeoxycholic acid inhibits the reaction [N-palmitoylsphingosine results in increased expression of ITPR2 mRNA]
CTD PMID:28223344 NCBI chr 4:180,423,452...180,800,088
Ensembl chr 4:180,538,389...180,722,358
JBrowse link
G Lipc lipase C, hepatic type multiple interactions ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of N-palmitoylsphingosine CTD PMID:24777581 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248
JBrowse link
G Lipg lipase G, endothelial type multiple interactions ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of N-palmitoylsphingosine CTD PMID:24777581 NCBI chr18:70,903,528...70,924,434
Ensembl chr18:70,901,710...70,924,708
JBrowse link
G Mfn2 mitofusin 2 increases expression
multiple interactions
ISO N-palmitoylsphingosine results in increased expression of MFN2 mRNA
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of MFN2 mRNA; tauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of MFN2 mRNA]
CTD PMID:28223344 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Pacs2 phosphofurin acidic cluster sorting protein 2 increases expression
multiple interactions
ISO N-palmitoylsphingosine results in increased expression of PACS2 mRNA
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of PACS2 mRNA; tauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of PACS2 mRNA]
CTD PMID:28223344 NCBI chr 6:137,824,136...137,889,144
Ensembl chr 6:137,824,213...137,887,418
JBrowse link
G Pc pyruvate carboxylase multiple interactions ISO [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased activity of PC protein; tauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased activity of PC protein] CTD PMID:28223344 NCBI chr 1:219,759,157...219,859,854
Ensembl chr 1:219,759,183...219,859,848
JBrowse link
G Tnf tumor necrosis factor increases abundance
multiple interactions
ISO TNF protein results in increased abundance of N-palmitoylsphingosine
ASAH2 protein inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine]
Imipramine inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine]
CTD PMID:15946935 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vdac1 voltage-dependent anion channel 1 multiple interactions ISO [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of VDAC1 mRNA; tauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of VDAC1 mRNA] CTD PMID:28223344 NCBI chr10:37,724,915...37,752,827
Ensembl chr10:37,724,915...37,752,826
JBrowse link
phytosphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization
multiple interactions
ISO phytosphingosine affects the localization of AIFM1 protein
3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [phytosphingosine affects the localization of AIFM1 protein]
CTD PMID:15486061 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
affects localization
ISO 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein]; [arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein; Acetylcysteine inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein]; SB 203580 inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein]
phytosphingosine affects the localization of BAX protein
CTD PMID:15486061, PMID:17237268 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Casp3 caspase 3 multiple interactions ISO 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP3 protein]; [arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP3 protein; SB 203580 inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP3 protein] CTD PMID:17237268 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions ISO 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP9 protein]; [arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP9 protein; SB 203580 inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP9 protein] CTD PMID:17237268 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [arsenic trioxide co-treated with phytosphingosine] results in decreased phosphorylation of MAPK1 protein CTD PMID:17237268 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased phosphorylation of MAPK14 protein]; [arsenic trioxide co-treated with phytosphingosine] results in increased phosphorylation of MAPK14 protein; Acetylcysteine inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased phosphorylation of MAPK14 protein] CTD PMID:17237268 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [arsenic trioxide co-treated with phytosphingosine] results in decreased phosphorylation of MAPK3 protein CTD PMID:17237268 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases activity
ISO 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of PARP1 protein]; [Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of PARP1 protein; [Arsenic Trioxide co-treated with phytosphingosine] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of PARP1 protein]
phytosphingosine results in increased activity of PARP1 protein
CTD PMID:15486061, PMID:17237268 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
rosuvastatin calcium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 decreases expression
multiple interactions
ISO Rosuvastatin Calcium results in decreased expression of ABCA1 mRNA
Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of ABCA1 mRNA]
CTD PMID:18192897 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO
EXP
Rosuvastatin Calcium inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]
[Cyclosporine results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium; [Glyburide results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium; [troglitazone results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium
CTD PMID:15901796, PMID:19853032 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression
affects secretion
ISO
EXP
ABCC2 protein binds to and results in increased uptake of Rosuvastatin Calcium analog; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]
Rosuvastatin Calcium results in increased expression of ABCC2 protein
[Benzbromarone results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; [Probenecid results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; [Sulfasalazine results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; ABCC2 protein binds to and results in increased uptake of Rosuvastatin Calcium analog; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Rosuvastatin Calcium promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]
ABCC2 protein affects the secretion of Rosuvastatin Calcium
CTD PMID:19853032, PMID:23562342, PMID:24909372 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Rosuvastatin Calcium results in increased expression of ABCC3 protein CTD PMID:24909372 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 decreases expression ISO Rosuvastatin Calcium results in decreased expression of ABCG1 mRNA CTD PMID:18192897 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases activity
EXP
ISO
[Novobiocin results in decreased activity of ABCG2 protein] which results in decreased secretion of Rosuvastatin Calcium
Rosuvastatin Calcium results in increased activity of ABCG2 protein
CTD PMID:19853032, PMID:30083819 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects phosphorylation EXP Rosuvastatin Calcium affects the phosphorylation of AKT1 protein CTD PMID:27815113 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions
increases expression
ISO Niacin promotes the reaction [Rosuvastatin Calcium results in increased expression of APOA1 protein] CTD PMID:12767421, PMID:15539964 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apob apolipoprotein B decreases expression ISO Rosuvastatin Calcium results in decreased expression of APOB protein CTD PMID:15539964, PMID:18702965 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of BAX mRNA] CTD PMID:32007421 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Rosuvastatin Calcium results in decreased expression of BCL2 protein CTD PMID:20852871 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases activity ISO Rosuvastatin Calcium results in increased activity of CASP3 protein CTD PMID:21478229 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase increases activity
multiple interactions
EXP Rosuvastatin Calcium results in increased activity of CAT protein
[Rosuvastatin Calcium co-treated with Isoproterenol] inhibits the reaction [Interleukin-6 results in increased expression of CAT protein]; Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]
CTD PMID:20146376, PMID:32007421 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression EXP Rosuvastatin Calcium results in decreased expression of CCL2 mRNA CTD PMID:15681303 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Creb5 cAMP responsive element binding protein 5 decreases expression ISO Rosuvastatin Calcium results in decreased expression of CREB5 mRNA CTD PMID:18192897 NCBI chr 4:83,390,782...83,840,356
Ensembl chr 4:83,391,283...83,836,351
JBrowse link
G Crp C-reactive protein multiple interactions ISO Rosuvastatin Calcium inhibits the reaction [CRP protein results in decreased expression of NOS3] CTD PMID:21562509 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
decreases expression
EXP [[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species CTD PMID:21562509 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions
decreases expression
ISO
EXP
Rosuvastatin Calcium inhibits the reaction [Nitroglycerin results in increased expression of CYBB mRNA]
[[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species
CTD PMID:16633368, PMID:21562509 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO Rosuvastatin Calcium results in increased expression of GCLC mRNA
[Tetradecanoylphorbol Acetate co-treated with Rosuvastatin Calcium] results in increased expression of GCLC mRNA
CTD PMID:18154958 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gpr183 G protein-coupled receptor 183 multiple interactions
increases expression
ISO Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in increased expression of GPR183 mRNA] CTD PMID:18192897 NCBI chr15:108,364,701...108,376,221
Ensembl chr15:108,364,701...108,376,221
JBrowse link
G Gzmk granzyme K multiple interactions
increases expression
ISO Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in increased expression of GZMK mRNA] CTD PMID:18192897 NCBI chr 2:45,069,136...45,077,154
Ensembl chr 2:45,068,967...45,077,219
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha increases secretion ISO HNF4A protein results in increased secretion of Rosuvastatin Calcium CTD PMID:27160211 NCBI chr 3:159,902,441...159,965,003
Ensembl chr 3:159,902,441...159,965,003
JBrowse link
G Il18rap interleukin 18 receptor accessory protein decreases expression
multiple interactions
ISO Rosuvastatin Calcium results in decreased expression of IL18RAP mRNA
Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of IL18RAP mRNA]
CTD PMID:18192897 NCBI chr 9:47,225,543...47,255,805
Ensembl chr 9:47,225,585...47,258,503
JBrowse link
G Il1b interleukin 1 beta decreases expression EXP Rosuvastatin Calcium results in decreased expression of IL1B mRNA CTD PMID:15681303 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Rosuvastatin Calcium results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kcnj15 potassium inwardly-rectifying channel, subfamily J, member 15 decreases expression ISO Rosuvastatin Calcium results in decreased expression of KCNJ15 mRNA CTD PMID:18192897 NCBI chr11:35,545,185...35,588,517
Ensembl chr11:35,568,182...35,585,390
JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein] CTD PMID:27097221 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Mb myoglobin affects expression EXP Rosuvastatin Calcium affects the expression of MB protein CTD PMID:27815113 NCBI chr 7:118,101,633...118,108,864
Ensembl chr 7:118,101,634...118,108,864
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in decreased expression of NFE2L2 mRNA] CTD PMID:32007421 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
EXP Rosuvastatin Calcium results in increased expression of NOS2 mRNA
Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of NOS2 mRNA]
CTD PMID:21443142, PMID:32007421 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases expression
affects response to substance
ISO
EXP
Rosuvastatin Calcium inhibits the reaction [CRP protein results in decreased expression of NOS3]; Rosuvastatin Calcium results in increased phosphorylation of and results in increased activity of NOS3 protein
Rosuvastatin Calcium results in increased expression of NOS3 mRNA
NOS3 protein affects the susceptibility to Rosuvastatin Calcium
CTD PMID:12354446, PMID:15681303, PMID:18162361, PMID:21562509 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Orm1 orosomucoid 1 multiple interactions
decreases expression
ISO Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of ORM1 mRNA] CTD PMID:18192897 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions ISO Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PECAM1 protein] CTD PMID:27097221 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Selp selectin P decreases expression EXP Rosuvastatin Calcium results in decreased expression of SELP mRNA CTD PMID:15681303 NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628
JBrowse link
G Serpine2 serpin family E member 2 multiple interactions ISO Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SERPINE2 protein]; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein] CTD PMID:27097221 NCBI chr 9:85,560,852...85,629,410
Ensembl chr 9:85,560,863...85,626,094
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions
increases uptake
decreases expression
affects transport
EXP
ISO
Fusidic Acid inhibits the reaction [SLCO1A4 protein results in increased uptake of Rosuvastatin Calcium]
diosmetin inhibits the reaction [SLCO1A2 protein results in increased uptake of Rosuvastatin Calcium]
Rosuvastatin Calcium results in decreased expression of SLCO1A4 protein
SLCO1A4 protein affects the transport of Rosuvastatin Calcium
CTD PMID:19833843, PMID:24909372, PMID:26888941, PMID:28867436 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions
increases uptake
EXP
ISO
Fusidic Acid inhibits the reaction [SLCO1B2 protein results in increased uptake of Rosuvastatin Calcium]
Fusidic Acid inhibits the reaction [SLCO1B3 protein results in increased uptake of Rosuvastatin Calcium]
CTD PMID:26888941, PMID:31299240 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions
increases uptake
ISO Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of Rosuvastatin Calcium] CTD PMID:24285294 NCBI chr 1:164,623,313...164,671,612
Ensembl chr 1:164,623,599...164,671,577
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression
EXP [[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species CTD PMID:21562509 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression
ISO
EXP
Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TGFB1 protein]; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]
Rosuvastatin Calcium results in decreased expression of TGFB1 mRNA
CTD PMID:15681303, PMID:27097221 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
EXP Rosuvastatin Calcium results in decreased expression of TNF mRNA
Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of TNF protein]
CTD PMID:15681303, PMID:32007421 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions EXP Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of TNNI3 protein] CTD PMID:32007421 NCBI chr 1:72,882,806...72,886,490
Ensembl chr 1:72,882,806...72,886,488
JBrowse link
G Vnn3 vanin 3 decreases expression ISO Rosuvastatin Calcium results in decreased expression of VNN3 mRNA CTD PMID:18192897 NCBI chr 1:22,649,114...22,661,376
Ensembl chr 1:22,649,081...22,661,377
JBrowse link
G Wt1 WT1 transcription factor increases expression EXP Rosuvastatin Calcium results in increased expression of WT1 mRNA CTD PMID:21443142 NCBI chr 3:95,133,221...95,180,574
Ensembl chr 3:95,133,713...95,180,564
JBrowse link
sphinganine 1-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO dihydrosphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; dihydrosphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 protein]; dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 protein]
dihydrosphingosine 1-phosphate results in increased expression of PTGS2 mRNA; dihydrosphingosine 1-phosphate results in increased expression of PTGS2 protein
CTD PMID:18612546 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Spns2 sphingolipid transporter 2 decreases abundance ISO SPNS2 protein results in decreased abundance of dihydrosphingosine 1-phosphate CTD PMID:29772789 NCBI chr10:59,010,428...59,049,482
Ensembl chr10:59,010,428...59,049,482
JBrowse link
sphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone multiple interactions EXP Sphingosine inhibits the reaction [CRH protein inhibits the reaction [CGB3 protein results in increased chemical synthesis of Cyclic AMP]] CTD PMID:2153673 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO Sphingosine results in increased expression of CYP17A1 mRNA CTD PMID:15666826 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Sphingosine inhibits the reaction [CRH protein inhibits the reaction [CGB3 protein results in increased chemical synthesis of Cyclic AMP]]; Sphingosine inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [CGB3 protein results in increased chemical synthesis of Cyclic AMP]] CTD PMID:2153673 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Tat tyrosine aminotransferase multiple interactions EXP Sphingosine inhibits the reaction [Calcimycin promotes the reaction [Dexamethasone results in increased activity of TAT protein]]; Sphingosine inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Dexamethasone results in increased activity of TAT protein]]; Sphingosine inhibits the reaction [Ursodeoxycholic Acid promotes the reaction [Dexamethasone results in increased activity of TAT protein]] CTD PMID:9398635 NCBI chr19:41,675,639...41,686,195
Ensembl chr19:41,675,355...41,686,229
JBrowse link
G Tert telomerase reverse transcriptase affects activity ISO Sphingosine affects the activity of TERT protein CTD PMID:9434777 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
sphingosine 1-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO sphingosine 1-phosphate results in increased phosphorylation of and results in increased activity of AKT1 protein
sphingosine 1-phosphate results in increased phosphorylation of AKT1 protein
CTD PMID:15946935, PMID:16365044 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
multiple interactions
ISO sphingosine 1-phosphate results in decreased expression of BAX mRNA
sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA]
CTD PMID:24399507 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BCL2 mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 protein] CTD PMID:24399507, PMID:24420784 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression ISO sphingosine 1-phosphate results in increased expression of CCN2 mRNA CTD PMID:25690654 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation
multiple interactions
ISO sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein]
CTD PMID:18612546 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 decreases expression ISO sphingosine 1-phosphate results in decreased expression of CXCR1 mRNA CTD PMID:16224106 NCBI chr 9:81,466,430...81,469,299
Ensembl chr 9:81,466,332...81,469,274
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO sphingosine 1-phosphate results in increased expression of CYP17A1 mRNA CTD PMID:15666826 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Egfr epidermal growth factor receptor increases phosphorylation
multiple interactions
ISO sphingosine 1-phosphate results in increased phosphorylation of EGFR protein
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of EGFR protein]
CTD PMID:26518876 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Fn1 fibronectin 1 multiple interactions
increases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein; [sphingosine 1-phosphate results in increased activity of S1PR2 protein] which results in increased expression of FN1; Curcumin inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; SB 203580 inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein] CTD PMID:21998146, PMID:22406263 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Gnaq G protein subunit alpha q multiple interactions
increases expression
ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of GNAQ protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of GNAQ protein] CTD PMID:25980589 NCBI chr 1:233,382,778...233,622,584
Ensembl chr 1:233,382,708...233,622,786
JBrowse link
G Hgf hepatocyte growth factor increases expression ISO sphingosine 1-phosphate results in increased expression of HGF mRNA CTD PMID:19349368 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hrk harakiri, BCL2 interacting protein multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HRK mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in increased expression of HRK mRNA] CTD PMID:24399507, PMID:24420784 NCBI chr12:44,008,879...44,029,211 JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO sphingosine 1-phosphate results in increased expression of IGF1 mRNA CTD PMID:19349368 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL6 mRNA] CTD PMID:26518876 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of KDR mRNA]; sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of KDR mRNA] CTD PMID:15741222 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Lama3 laminin subunit alpha 3 increases expression ISO sphingosine 1-phosphate results in increased expression of LAMA3 mRNA CTD PMID:15541073 NCBI chr18:3,704,866...3,941,215
Ensembl chr18:3,705,916...3,940,838
JBrowse link
G Lamb3 laminin subunit beta 3 increases expression ISO sphingosine 1-phosphate results in increased expression of LAMB3 mRNA CTD PMID:15541073 NCBI chr13:112,031,614...112,073,187
Ensembl chr13:112,031,594...112,073,186
JBrowse link
G Lamc2 laminin subunit gamma 2 increases expression ISO sphingosine 1-phosphate results in increased expression of LAMC2 mRNA CTD PMID:15541073 NCBI chr13:70,566,643...70,632,126
Ensembl chr13:70,566,643...70,626,252
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein]; Plant Extracts inhibits the reaction [sphingosine 1-phosphate results in increased activity of and results in increased phosphorylation of MAPK1 protein]; sphingosine 1-phosphate results in increased phosphorylation of and results in increased activity of MAPK1 protein; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK1 protein modified form]; [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK1 protein modified form
CTD PMID:16365044, PMID:18612546, PMID:22251058, PMID:22406263, PMID:26518876 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO
EXP
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]; Plant Extracts inhibits the reaction [sphingosine 1-phosphate results in increased activity of and results in increased phosphorylation of MAPK3 protein]; sphingosine 1-phosphate results in increased phosphorylation of and results in increased activity of MAPK3 protein; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK3 protein modified form]; [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK3 protein modified form
CTD PMID:16365044, PMID:18612546, PMID:22251058, PMID:22406263, PMID:26518876 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
increases expression
ISO JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP2 mRNA]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP2 protein]
sphingosine 1-phosphate results in increased expression of MMP2 mRNA; sphingosine 1-phosphate results in increased expression of MMP2 protein
CTD PMID:26518876 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases expression
ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein]
sphingosine 1-phosphate results in increased expression of MMP9 mRNA; sphingosine 1-phosphate results in increased expression of MMP9 protein
CTD PMID:25980589, PMID:26518876 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nrp1 neuropilin 1 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP1 mRNA]; sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP1 mRNA] CTD PMID:15741222 NCBI chr19:61,332,351...61,486,166
Ensembl chr19:61,332,351...61,485,858
JBrowse link
G Nrp2 neuropilin 2 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP2 mRNA]; sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP2 mRNA] CTD PMID:15741222 NCBI chr 9:69,496,875...69,609,802
Ensembl chr 9:69,497,121...69,612,087
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 increases expression ISO sphingosine 1-phosphate results in increased expression of PECAM1 protein CTD PMID:19349368 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Plcb4 phospholipase C, beta 4 increases expression
multiple interactions
ISO sphingosine 1-phosphate results in increased expression of PLCB4 protein
Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of PLCB4 protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of PLCB4 protein]
CTD PMID:25980589 NCBI chr 3:128,601,163...128,971,720
Ensembl chr 3:128,756,799...128,971,746
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP [Bezafibrate results in increased activity of PPARA protein] which results in decreased abundance of sphingosine 1-phosphate CTD PMID:18024222 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; JTE 013 inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; JTE 013 promotes the reaction [Suramin inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; MK 2206 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; S1PR2 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; S1PR3 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 protein]; sphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; Suramin inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; Suramin promotes the reaction [JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]
sphingosine 1-phosphate results in increased expression of PTGS2 mRNA; sphingosine 1-phosphate results in increased expression of PTGS2 protein
CTD PMID:18612546, PMID:26518876 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization
ISO JTE 013 inhibits the reaction [sphingosine 1-phosphate affects the localization of RELA protein modified form] CTD PMID:26518876 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 increases response to substance
increases expression
multiple interactions
EXP
ISO
S1PR1 protein results in increased susceptibility to sphingosine 1-phosphate
sphingosine 1-phosphate results in increased expression of S1PR1 mRNA
sphingosine 1-phosphate binds to and results in increased activity of S1PR1 protein
CTD PMID:20844107, PMID:24399507 NCBI chr 2:218,654,406...218,658,761
Ensembl chr 2:218,654,554...218,658,761
JBrowse link
G S1pr2 sphingosine-1-phosphate receptor 2 multiple interactions
increases uptake
increases activity
ISO
EXP
S1PR2 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]
sphingosine 1-phosphate results in increased uptake of S1PR2 protein
sphingosine 1-phosphate results in increased activity of S1PR2 protein
[JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] results in decreased susceptibility to [sphingosine 1-phosphate co-treated with Glucose]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] which results in decreased susceptibility to sphingosine 1-phosphate; [sphingosine 1-phosphate results in increased activity of S1PR2 protein] which results in increased expression of FN1
CTD PMID:18612546, PMID:22406263, PMID:26518876 NCBI chr 8:21,984,914...21,995,806
Ensembl chr 8:21,984,914...21,995,806
JBrowse link
G S1pr3 sphingosine-1-phosphate receptor 3 multiple interactions
increases expression
ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR3 protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR3 protein]; S1PR3 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA] CTD PMID:18612546, PMID:25980589 NCBI chr17:13,799,383...13,812,877
Ensembl chr17:13,799,383...13,812,704
JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [Thalidomide results in increased activity of SMPD2 protein] CTD PMID:15741222 NCBI chr20:46,212,070...46,215,183
Ensembl chr20:46,211,892...46,215,120
JBrowse link
G Sphk1 sphingosine kinase 1 increases chemical synthesis
multiple interactions
ISO SPHK1 protein results in increased chemical synthesis of sphingosine 1-phosphate
[resveratrol affects the localization of and results in decreased activity of SPHK1 protein] which results in decreased abundance of sphingosine 1-phosphate; sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SPHK1 mRNA]; sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SPHK1 protein]
CTD PMID:22251058, PMID:24399507, PMID:26045781 NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393
JBrowse link
G Spns2 sphingolipid transporter 2 increases secretion
multiple interactions
ISO SPNS2 protein results in increased secretion of sphingosine 1-phosphate
TGFB2 protein promotes the reaction [SPNS2 protein results in increased secretion of sphingosine 1-phosphate]
CTD PMID:29772789 NCBI chr10:59,010,428...59,049,482
Ensembl chr10:59,010,428...59,049,482
JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions ISO TGFB2 protein promotes the reaction [SPNS2 protein results in increased secretion of sphingosine 1-phosphate] CTD PMID:29772789 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of TNF mRNA]; sphingosine 1-phosphate inhibits the reaction [TNF results in increased expression of VCAM1] CTD PMID:18981156, PMID:26518876 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [TNF results in increased expression of VCAM1] CTD PMID:18981156 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    chemical entity 19810
      atom 19808
        nonmetal atom 19683
          nitrogen atom 18565
            nitrogen molecular entity 18565
              organonitrogen compound 18335
                sphingolipid 183
                  (+)-Prosopinine 0
                  1-O-(alpha-D-galactopyranosyl)-N-hexacosanoyl-D-xylo-phytosphingosine 0
                  L-erythro-N-acylsphingosine 0
                  L-erythro-N-dodecanoylsphingosine 0
                  Sphingosine 1-phosphate (d19:1-P) 0
                  ceramide + 108
                  glycosphingolipid + 25
                  hexadecasphinganine-based sphingolipid 0
                  hexadecasphingosine-based sphingolipid 0
                  phosphonosphingolipid + 0
                  phosphosphingolipid + 77
                  sphinganine-based sphingolipid + 3
                  sphingoid + 161
                  sphingosine-based sphingolipid + 81
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            heteroorganic entity 19175
                              organochalcogen compound 18886
                                organooxygen compound 18809
                                  sphingolipid 183
                                    (+)-Prosopinine 0
                                    1-O-(alpha-D-galactopyranosyl)-N-hexacosanoyl-D-xylo-phytosphingosine 0
                                    L-erythro-N-acylsphingosine 0
                                    L-erythro-N-dodecanoylsphingosine 0
                                    Sphingosine 1-phosphate (d19:1-P) 0
                                    ceramide + 108
                                    glycosphingolipid + 25
                                    hexadecasphinganine-based sphingolipid 0
                                    hexadecasphingosine-based sphingolipid 0
                                    phosphonosphingolipid + 0
                                    phosphosphingolipid + 77
                                    sphinganine-based sphingolipid + 3
                                    sphingoid + 161
                                    sphingosine-based sphingolipid + 81
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.