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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
multiple interactions |
ISO |
[Acetaminophen co-treated with Sodium Chloride] results in decreased expression of ABCB11 mRNA |
CTD |
PMID:17934960 |
|
NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
[Acetaminophen co-treated with Sodium Chloride] results in increased expression of ABCB1A mRNA |
CTD |
PMID:17934960 |
|
NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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G |
Abcb1b |
ATP-binding cassette, subfamily B (MDR/TAP), member 1B |
multiple interactions |
ISO |
[Acetaminophen co-treated with Sodium Chloride] results in increased expression of ABCB1B mRNA |
CTD |
PMID:17934960 |
|
NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
multiple interactions |
ISO |
[Acetaminophen co-treated with Sodium Chloride] results in increased expression of ABCC1 mRNA |
CTD |
PMID:17934960 |
|
NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions |
ISO |
[Acetaminophen co-treated with Sodium Chloride] results in increased expression of ABCC2 mRNA |
CTD |
PMID:17934960 |
|
NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
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G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
multiple interactions |
ISO |
[Acetaminophen co-treated with Sodium Chloride] results in increased expression of ABCC3 mRNA |
CTD |
PMID:17934960 |
|
NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
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G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
multiple interactions |
ISO |
[Acetaminophen co-treated with Sodium Chloride] results in increased expression of ABCC4 mRNA |
CTD |
PMID:17934960 |
|
NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
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G |
Ace |
angiotensin I converting enzyme |
multiple interactions |
ISO |
ACE gene polymorphism affects the susceptibility to [Enalapril co-treated with Sodium Chloride]; ACE gene polymorphism inhibits the reaction [[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form] |
CTD |
PMID:20829712 |
|
NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
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G |
Agt |
angiotensinogen |
multiple interactions increases expression |
ISO EXP |
[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form; ACE gene polymorphism inhibits the reaction [[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form] Sodium Chloride results in increased expression of AGT protein [AGT protein co-treated with Sodium Chloride] affects the expression of ALOX5 mRNA; [AGT protein co-treated with Sodium Chloride] affects the expression of HPGDS mRNA; [AGT protein co-treated with Sodium Chloride] affects the expression of PLA2G4A mRNA; [AGT protein co-treated with Sodium Chloride] affects the expression of PLA2G4A protein; [AGT protein co-treated with Sodium Chloride] affects the expression of PTGDR mRNA; [AGT protein co-treated with Sodium Chloride] affects the expression of PTGDS mRNA; [AGT protein co-treated with Sodium Chloride] affects the expression of PTGES3 mRNA; [AGT protein co-treated with Sodium Chloride] affects the expression of PTGIS mRNA; [AGT protein co-treated with Sodium Chloride] affects the expression of PTGS1 mRNA; AGTR2 protein inhibits the reaction [Sodium Chloride results in increased activity of AGT protein]; Losartan inhibits the reaction [Sodium Chloride results in increased expression of AGT protein] |
CTD |
PMID:15809360 PMID:20232302 PMID:20829712 PMID:27225954 |
|
NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
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G |
Agtr2 |
angiotensin II receptor, type 2 |
decreases expression multiple interactions |
EXP |
Sodium Chloride results in decreased expression of AGTR2 mRNA; Sodium Chloride results in decreased expression of AGTR2 protein AGTR2 protein inhibits the reaction [Sodium Chloride results in increased activity of AGT protein] |
CTD |
PMID:15809360 |
|
NCBI chr X:119,389,480...119,393,845
Ensembl chr X:119,390,013...119,393,842
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G |
Akr1b1 |
aldo-keto reductase family 1 member B |
increases expression multiple interactions |
ISO |
Sodium Chloride results in increased expression of AKR1B3 mRNA Lipopolysaccharides inhibits the reaction [Sodium Chloride results in increased expression of AKR1B3 mRNA] |
CTD |
PMID:23867654 |
|
NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
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G |
Alox5 |
arachidonate 5-lipoxygenase |
multiple interactions |
EXP |
[AGT protein co-treated with Sodium Chloride] affects the expression of ALOX5 mRNA |
CTD |
PMID:27225954 |
|
NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
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G |
Arrb2 |
arrestin, beta 2 |
multiple interactions |
ISO |
Sodium Chloride affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- affects the localization of ARRB2 protein] |
CTD |
PMID:27030709 |
|
NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
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G |
Atp2a2 |
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 |
multiple interactions decreases expression |
EXP |
simendan inhibits the reaction [Sodium Chloride results in decreased expression of ATP2A2 mRNA] |
CTD |
PMID:17325658 |
|
NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
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G |
Avp |
arginine vasopressin |
increases expression |
ISO EXP |
Sodium Chloride results in increased expression of AVP protein Sodium Chloride results in increased expression of AVP mRNA |
CTD |
PMID:7923825 PMID:19463813 |
|
NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP |
[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of BAX protein; [Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of BAX protein; acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of BAX protein]; atrasentan inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of BAX protein] |
CTD |
PMID:16030430 PMID:22431579 |
|
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
EXP |
[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of BCL2 protein; [Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein; [S-allylcysteine co-treated with lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein]; acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of BCL2 protein]; atrasentan inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of BCL2 protein]; lycopene inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein]; S-allylcysteine inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein] |
CTD |
PMID:16030430 PMID:22431579 |
|
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Bcl2l11 |
BCL2 like 11 |
multiple interactions |
EXP |
[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of BCL2L11 protein; S-allylcysteine inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of BCL2L11 protein] |
CTD |
PMID:16030430 |
|
NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
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G |
Calca |
calcitonin-related polypeptide alpha |
multiple interactions increases expression |
ISO EXP |
[Sodium Chloride co-treated with Ethanol] results in increased expression of CALCA protein Sodium Chloride promotes the reaction [arachidonyl dopamine results in increased expression of CALCA protein]; Sodium Chloride promotes the reaction [arachidonyl dopamine results in increased secretion of CALCA protein] Sodium Chloride results in increased expression of CALCA protein |
CTD |
PMID:17984664 PMID:18054007 |
|
NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
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G |
Casp2 |
caspase 2 |
increases expression |
ISO |
Sodium Chloride results in increased expression of CASP2 mRNA |
CTD |
PMID:23634900 |
|
NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
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G |
Casp3 |
caspase 3 |
multiple interactions increases activity |
EXP ISO |
[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP3 protein; [S-allylcysteine co-treated with Lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP3 protein] Sodium Chloride results in increased activity of CASP3 protein |
CTD |
PMID:15975986 PMID:16030430 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Casp8 |
caspase 8 |
increases expression multiple interactions |
ISO EXP |
Sodium Chloride results in increased expression of CASP8 mRNA [Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein; [S-allylcysteine co-treated with lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]; lycopene inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]; S-allylcysteine inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein] |
CTD |
PMID:16030430 PMID:23634900 |
|
NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
increases expression |
ISO |
Sodium Chloride results in increased expression of CCL2 mRNA |
CTD |
PMID:23634900 |
|
NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
increases expression |
EXP |
Sodium Chloride results in increased expression of CCL5 protein |
CTD |
PMID:20232302 |
|
NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
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G |
Cd38 |
CD38 molecule |
multiple interactions |
ISO |
CD38 gene mutant form promotes the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] affects the localization of [NPHS2 protein co-treated with CDH3 protein]]; CD38 gene mutant form promotes the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] affects the localization of [NPHS2 protein co-treated with TJP1 protein]] |
CTD |
PMID:21992601 |
|
NCBI chr14:71,714,768...71,754,990
Ensembl chr14:71,715,269...71,754,672
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G |
Cd68 |
Cd68 molecule |
multiple interactions |
ISO |
[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CD68 mRNA; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CD68 mRNA] |
CTD |
PMID:27678262 |
|
NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640
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G |
Cdh3 |
cadherin 3 |
multiple interactions |
ISO |
[Desoxycorticosterone Acetate co-treated with Sodium Chloride] affects the localization of [NPHS2 protein co-treated with CDH3 protein]; CD38 gene mutant form promotes the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] affects the localization of [NPHS2 protein co-treated with CDH3 protein]] |
CTD |
PMID:21992601 |
|
NCBI chr19:38,668,957...38,719,801
Ensembl chr19:38,669,230...38,719,677
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
decreases expression |
ISO |
Sodium Chloride results in decreased expression of CDKN1A mRNA |
CTD |
PMID:24211769 |
|
NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
increases expression |
ISO |
Sodium Chloride results in increased expression of CEBPA mRNA |
CTD |
PMID:23634900 |
|
NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
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G |
Cldn4 |
claudin 4 |
multiple interactions increases expression |
EXP |
[[SP1 protein co-treated with JUN protein] binds to CLDN4 promoter] promotes the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; diphenyleneiodonium inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]; diphenyleneiodonium inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]; Glutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; U 0126 inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]; U 0126 inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] Sodium Chloride results in increased expression of CLDN4 mRNA; Sodium Chloride results in increased expression of CLDN4 protein |
CTD |
PMID:23816505 |
|
NCBI chr12:24,761,210...24,763,008
Ensembl chr12:24,761,210...24,763,005
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G |
Col1a1 |
collagen type I alpha 1 chain |
increases expression |
ISO |
Sodium Chloride results in increased expression of COL1A1 mRNA |
CTD |
PMID:23634900 |
|
NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
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G |
Cs |
citrate synthase |
multiple interactions |
EXP |
[Desoxycorticosterone Acetate co-treated with Sodium Chloride co-treated with cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester] results in increased expression of CS protein |
CTD |
PMID:29621749 |
|
NCBI chr 7:2,752,680...2,778,963
Ensembl chr 7:2,752,680...2,778,963
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G |
Cxcr2 |
C-X-C motif chemokine receptor 2 |
multiple interactions |
ISO |
CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CD68 mRNA]; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CYBA mRNA]; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CYBB mRNA]; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of IL1B mRNA]; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of IL6 mRNA]; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of NOX1 mRNA]; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of NOX4 mRNA]; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of TNF mRNA]; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of VCAM1 mRNA] |
CTD |
PMID:27678262 |
|
NCBI chr 9:81,427,275...81,435,065
Ensembl chr 9:81,427,730...81,434,102
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G |
Cyba |
cytochrome b-245 alpha chain |
multiple interactions |
EXP ISO |
[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of CYBA protein [Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CYBA mRNA; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CYBA mRNA] |
CTD |
PMID:22431579 PMID:27678262 |
|
NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
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G |
Cybb |
cytochrome b-245 beta chain |
multiple interactions |
ISO |
[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CYBB mRNA; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CYBB mRNA] |
CTD |
PMID:27678262 |
|
NCBI chr X:14,578,330...14,610,049
Ensembl chr X:14,578,264...14,612,547
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G |
Cyp11b3 |
cytochrome P450, family 11, subfamily b, polypeptide 3 |
increases expression increases activity |
EXP |
Sodium Chloride results in increased expression of CYP11B2 mRNA Sodium Chloride results in increased activity of CYP11B2 protein |
CTD |
PMID:15134804 |
|
NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
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G |
Des |
desmin |
multiple interactions |
ISO |
[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of DES protein |
CTD |
PMID:21992601 |
|
NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294
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G |
Edn1 |
endothelin 1 |
multiple interactions |
EXP |
[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in increased expression of EDN1 mRNA |
CTD |
PMID:18823320 |
|
NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
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G |
Ednra |
endothelin receptor type A |
multiple interactions |
ISO EXP |
[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] affects the activity of EDNRA protein [Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of EDNRA protein |
CTD |
PMID:18516094 PMID:22431579 |
|
NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703
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G |
Ednrb |
endothelin receptor type B |
multiple interactions |
EXP |
[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in decreased expression of EDNRB mRNA; atrasentan inhibits the reaction [[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in decreased expression of EDNRB mRNA] |
CTD |
PMID:18823320 |
|
NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354
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G |
Egfr |
epidermal growth factor receptor |
multiple interactions increases phosphorylation |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Sodium Chloride results in increased phosphorylation of EGFR protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Sodium Chloride results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [Sodium Chloride results in increased phosphorylation of EGFR protein]; Wortmannin inhibits the reaction [Sodium Chloride results in increased phosphorylation of EGFR protein] |
CTD |
PMID:21568938 |
|
NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
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G |
Egr1 |
early growth response 1 |
increases expression |
EXP |
Sodium Chloride results in increased expression of EGR1 |
CTD |
PMID:16280599 |
|
NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
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G |
Fgf2 |
fibroblast growth factor 2 |
multiple interactions increases secretion increases expression |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Sodium Chloride results in increased expression of FGF2 mRNA]; 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Sodium Chloride results in increased secretion of FGF2 protein]; Apigenin inhibits the reaction [Sodium Chloride results in increased expression of FGF2 mRNA]; Dactinomycin inhibits the reaction [Sodium Chloride results in increased expression of FGF2 mRNA]; Luteolin inhibits the reaction [Sodium Chloride results in increased expression of FGF2 mRNA]; NFAT5 protein affects the reaction [Sodium Chloride results in increased expression of FGF2 mRNA]; NFAT5 protein affects the reaction [Sodium Chloride results in increased secretion of FGF2 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of FGF2 mRNA]; Quercetin inhibits the reaction [Sodium Chloride results in increased expression of FGF2 mRNA]; SB 203580 inhibits the reaction [Sodium Chloride results in increased expression of FGF2 mRNA] |
CTD |
PMID:26800359 |
|
NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
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G |
Fmo1 |
flavin containing dimethylaniline monoxygenase 1 |
increases expression |
EXP |
Sodium Chloride results in increased expression of FMO1 mRNA; Sodium Chloride results in increased expression of FMO1 protein |
CTD |
PMID:19429252 |
|
NCBI chr13:80,712,885...80,745,095
Ensembl chr13:80,712,882...80,745,347
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression |
EXP ISO |
Sodium Chloride results in increased expression of FOS mRNA |
CTD |
PMID:19463813 PMID:23634900 |
|
NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
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G |
Fosl1 |
FOS like 1, AP-1 transcription factor subunit |
increases expression |
ISO |
Sodium Chloride results in increased expression of FOSL1 protein |
CTD |
PMID:20025956 |
|
NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
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G |
Foxo1 |
forkhead box O1 |
decreases expression |
ISO |
Sodium Chloride results in decreased expression of FOXO1 mRNA |
CTD |
PMID:23634900 |
|
NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
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G |
Gfap |
glial fibrillary acidic protein |
decreases expression increases expression |
EXP |
Sodium Chloride results in decreased expression of GFAP protein Sodium Chloride results in increased expression of GFAP mRNA |
CTD |
PMID:16280599 PMID:22954530 |
|
NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
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G |
Gja5 |
gap junction protein, alpha 5 |
multiple interactions |
ISO |
GJA5 affects the reaction [Sodium Chloride deficiency results in increased expression of REN mRNA] |
CTD |
PMID:19474190 |
|
NCBI chr 2:199,162,745...199,184,942
Ensembl chr 2:199,162,745...199,184,939
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G |
Gpx1 |
glutathione peroxidase 1 |
multiple interactions |
EXP |
[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of GPX1 protein; acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of GPX1 protein]; atrasentan inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of GPX1 protein] |
CTD |
PMID:22431579 |
|
NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
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G |
Hbegf |
heparin-binding EGF-like growth factor |
multiple interactions increases expression |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA]; Apigenin inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA]; cyanidin inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA]; Dactinomycin inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA]; epigallocatechin gallate affects the reaction [Sodium Chloride results in increased expression of HBEGF mRNA]; Luteolin inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA]; myricetin affects the reaction [Sodium Chloride results in increased expression of HBEGF mRNA]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA]; Quercetin inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA]; SB 203580 inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA] |
CTD |
PMID:26800359 |
|
NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions increases expression |
EXP |
tempol inhibits the reaction [Sodium Chloride results in increased expression of HIF1A protein] |
CTD |
PMID:20232302 |
|
NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
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G |
Hmox1 |
heme oxygenase 1 |
increases expression |
ISO |
Sodium Chloride results in increased expression of HMOX1 mRNA; Sodium Chloride results in increased expression of HMOX1 protein |
CTD |
PMID:11592956 |
|
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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G |
Hpgds |
hematopoietic prostaglandin D synthase |
multiple interactions |
EXP |
[AGT protein co-treated with Sodium Chloride] affects the expression of HPGDS mRNA |
CTD |
PMID:27225954 |
|
NCBI chr 4:95,945,356...95,970,666
Ensembl chr 4:95,946,025...95,970,666
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G |
Hsd11b2 |
hydroxysteroid 11-beta dehydrogenase 2 |
decreases expression decreases activity |
EXP |
Sodium Chloride results in decreased expression of HSD11B2 mRNA Sodium Chloride results in decreased activity of HSD11B2 protein |
CTD |
PMID:12943734 |
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NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
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G |
Hspa1b |
heat shock protein family A (Hsp70) member 1B |
increases expression |
ISO |
Sodium Chloride results in increased expression of HSPA1B mRNA; Sodium Chloride results in increased expression of HSPA1B protein |
CTD |
PMID:12085988 |
|
NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
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G |
Icam1 |
intercellular adhesion molecule 1 |
increases expression |
ISO |
Sodium Chloride results in increased expression of ICAM1 mRNA; Sodium Chloride results in increased expression of ICAM1 protein |
CTD |
PMID:11378323 PMID:23629852 |
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NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
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G |
Il1a |
interleukin 1 alpha |
increases expression |
ISO |
Sodium Chloride results in increased expression of IL1A mRNA |
CTD |
PMID:11378323 |
|
NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
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G |
Il1b |
interleukin 1 beta |
increases expression multiple interactions |
ISO |
Sodium Chloride results in increased expression of IL1B mRNA [Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of IL1B mRNA; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of IL1B mRNA] |
CTD |
PMID:11378323 PMID:26800359 PMID:27678262 |
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NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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G |
Il6 |
interleukin 6 |
increases expression multiple interactions |
ISO |
Sodium Chloride results in increased expression of IL6 mRNA [Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of IL6 mRNA; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of IL6 mRNA]; myxothiazol inhibits the reaction [Sodium Chloride inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; Rotenone inhibits the reaction [Sodium Chloride inhibits the reaction [Lipopolysaccharides promotes the reaction [NFAT5 protein binds to IL6 promoter]]]; Rotenone inhibits the reaction [Sodium Chloride inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; Rotenone inhibits the reaction [Sodium Chloride inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; Sodium Chloride inhibits the reaction [Lipopolysaccharides promotes the reaction [NFAT5 protein binds to IL6 promoter]]; Sodium Chloride inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Sodium Chloride inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] |
CTD |
PMID:11378323 PMID:23634900 PMID:23867654 PMID:27678262 |
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NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP |
[[SP1 protein co-treated with JUN protein] binds to CLDN4 promoter] promotes the reaction [Sodium Chloride results in increased expression of CLDN4 protein] |
CTD |
PMID:23816505 |
|
NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
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G |
Kcnj1 |
potassium inwardly-rectifying channel, subfamily J, member 1 |
decreases expression |
ISO |
Sodium Chloride results in decreased expression of KCNJ1 mRNA |
CTD |
PMID:19782052 |
|
NCBI chr 8:33,490,280...33,519,127
Ensembl chr 8:33,514,042...33,518,165
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases phosphorylation |
ISO EXP |
Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]; Reactive Oxygen Species affects the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]; Sodium Chloride results in decreased phosphorylation of and results in decreased activity of MAPK1 protein [19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in increased phosphorylation of MAPK1 protein; atrasentan inhibits the reaction [[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:15975986 PMID:16024921 PMID:18823320 |
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NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions |
ISO |
Sodium Chloride results in increased phosphorylation of and results in increased activity of MAPK14 protein |
CTD |
PMID:15975986 |
|
NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions increases phosphorylation |
ISO EXP |
Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein]; Reactive Oxygen Species affects the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein]; Sodium Chloride results in decreased phosphorylation of and results in decreased activity of MAPK3 protein [19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in increased phosphorylation of MAPK3 protein; atrasentan inhibits the reaction [[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:15975986 PMID:16024921 PMID:18823320 |
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NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Mmp2 |
matrix metallopeptidase 2 |
increases expression |
ISO |
Sodium Chloride results in increased expression of MMP2 mRNA |
CTD |
PMID:23634900 |
|
NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
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G |
Mt1 |
metallothionein 1 |
multiple interactions |
EXP |
[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased expression of MT1A protein; Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased expression of MT1A protein] |
CTD |
PMID:17616752 |
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NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
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G |
Nfat5 |
nuclear factor of activated T-cells 5 |
multiple interactions increases activity affects localization increases expression |
ISO |
[Sodium Chloride results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFAT5 protein; Apigenin inhibits the reaction [Sodium Chloride results in increased expression of NFAT5 mRNA]; Luteolin inhibits the reaction [Sodium Chloride results in increased expression of NFAT5 mRNA]; myxothiazol inhibits the reaction [Sodium Chloride results in increased activity of NFAT5 protein]; NFAT5 protein affects the reaction [Sodium Chloride results in increased expression of FGF2 mRNA]; NFAT5 protein affects the reaction [Sodium Chloride results in increased secretion of FGF2 protein]; Quercetin inhibits the reaction [Sodium Chloride results in increased expression of NFAT5 mRNA]; Rotenone inhibits the reaction [Sodium Chloride results in increased activity of NFAT5 protein] 2-bromoethylamine inhibits the reaction [Sodium Chloride affects the localization of NFAT5 protein]; 2-bromoethylamine inhibits the reaction [Sodium Chloride results in increased expression of NFAT5 mRNA]; 2-bromoethylamine inhibits the reaction [Sodium Chloride results in increased expression of NFAT5 protein]; Lipopolysaccharides promotes the reaction [Sodium Chloride affects the localization of NFAT5 protein]; Lipopolysaccharides promotes the reaction [Sodium Chloride results in increased expression of NFAT5 mRNA]; Rotenone inhibits the reaction [Sodium Chloride inhibits the reaction [Lipopolysaccharides promotes the reaction [NFAT5 protein binds to IL6 promoter]]]; Sodium Chloride inhibits the reaction [Lipopolysaccharides promotes the reaction [NFAT5 protein binds to IL6 promoter]]; Sodium Chloride promotes the reaction [Lipopolysaccharides affects the localization of NFAT5 protein]; Sodium Chloride promotes the reaction [Lipopolysaccharides results in increased expression of NFAT5 mRNA] Sodium Chloride results in increased expression of NFAT5 mRNA; Sodium Chloride results in increased expression of NFAT5 protein |
CTD |
PMID:16303854 PMID:20823374 PMID:23867654 PMID:26800359 |
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NCBI chr19:38,446,059...38,533,735
Ensembl chr19:38,446,059...38,533,735
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G |
Nos1 |
nitric oxide synthase 1 |
multiple interactions increases expression |
EXP |
[Ramipril co-treated with Sodium Chloride deficiency] results in increased expression of NOS1 protein; Metoprolol inhibits the reaction [[Ramipril co-treated with Sodium Chloride deficiency] results in increased expression of NOS1 protein]; Metoprolol inhibits the reaction [Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of NOS1 mRNA]]; Metoprolol inhibits the reaction [Sodium Chloride deficiency results in increased expression of NOS1 mRNA]; Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of NOS1 mRNA] |
CTD |
PMID:11832429 |
|
NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions decreases expression |
EXP |
[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in decreased expression of NOS3 protein; atrasentan inhibits the reaction [[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in decreased expression of NOS3 protein]; Losartan inhibits the reaction [Sodium Chloride results in decreased expression of NOS3 protein]; tempol inhibits the reaction [Sodium Chloride results in decreased expression of NOS3 protein] |
CTD |
PMID:18823320 PMID:20232302 |
|
NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
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G |
Nox1 |
NADPH oxidase 1 |
multiple interactions |
EXP ISO |
[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of NOX1 protein [Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of NOX1 mRNA; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of NOX1 mRNA] |
CTD |
PMID:22431579 PMID:27678262 |
|
NCBI chr X:104,909,328...104,932,508
Ensembl chr X:104,909,326...104,932,508
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G |
Nox4 |
NADPH oxidase 4 |
multiple interactions |
ISO |
[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of NOX4 mRNA; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of NOX4 mRNA] |
CTD |
PMID:27678262 |
|
NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
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G |
Nphs1 |
NPHS1 adhesion molecule, nephrin |
decreases expression |
ISO |
Sodium chloride decreases expression of Nphs1 mRNA in hyperaldosteronic kidney |
RGD |
PMID:24108235 |
RGD:38599161 |
NCBI chr 1:88,922,346...88,950,560
Ensembl chr 1:88,922,433...88,950,559
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G |
Nphs2 |
NPHS2 stomatin family member, podocin |
multiple interactions |
ISO |
[Desoxycorticosterone Acetate co-treated with Sodium Chloride] affects the localization of [NPHS2 protein co-treated with CDH3 protein]; [Desoxycorticosterone Acetate co-treated with Sodium Chloride] affects the localization of [NPHS2 protein co-treated with TJP1 protein]; [Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of NPHS2 protein; CD38 gene mutant form promotes the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] affects the localization of [NPHS2 protein co-treated with CDH3 protein]]; CD38 gene mutant form promotes the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] affects the localization of [NPHS2 protein co-treated with TJP1 protein]] |
CTD |
PMID:21992601 |
|
NCBI chr13:73,929,136...73,941,522
Ensembl chr13:73,929,136...73,941,522
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G |
Nppa |
natriuretic peptide A |
increases expression multiple interactions |
EXP |
Sodium Chloride results in increased expression of NPPA mRNA simendan inhibits the reaction [Sodium Chloride results in increased expression of NPPA mRNA] |
CTD |
PMID:17325658 |
|
NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
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G |
Nup88 |
nucleoporin 88 |
increases expression |
ISO |
Sodium Chloride results in increased expression of NUP88 protein |
CTD |
PMID:20823374 |
|
NCBI chr10:57,581,828...57,606,171
Ensembl chr10:57,581,828...57,606,171
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G |
Pdgfra |
platelet derived growth factor receptor alpha |
increases expression |
ISO |
Sodium Chloride results in increased expression of PDGFRA mRNA |
CTD |
PMID:23634900 |
|
NCBI chr14:35,527,926...35,581,130
Ensembl chr14:35,527,927...35,581,031
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G |
Pdgfrb |
platelet derived growth factor receptor beta |
increases expression |
ISO |
Sodium Chloride results in increased expression of PDGFRB mRNA |
CTD |
PMID:23634900 |
|
NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
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G |
Pdhx |
pyruvate dehydrogenase complex, component X |
multiple interactions |
EXP |
[Desoxycorticosterone Acetate co-treated with Sodium Chloride co-treated with cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester] results in increased expression of PDHX protein; [Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of PDHX protein |
CTD |
PMID:29621749 |
|
NCBI chr 3:92,910,300...92,933,725
Ensembl chr 3:92,909,725...92,969,050
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G |
Pgr |
progesterone receptor |
increases activity |
ISO |
Sodium Chloride results in increased activity of PGR protein |
CTD |
PMID:9879984 |
|
NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
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G |
Pla2g4a |
phospholipase A2 group IVA |
increases expression multiple interactions |
ISO EXP |
Sodium Chloride results in increased expression of PLA2G4A mRNA [AGT protein co-treated with Sodium Chloride] affects the expression of PLA2G4A mRNA; [AGT protein co-treated with Sodium Chloride] affects the expression of PLA2G4A protein |
CTD |
PMID:23634900 PMID:27225954 |
|
NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
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G |
Pomc |
proopiomelanocortin |
multiple interactions |
ISO |
[Guanosine Triphosphate co-treated with Sodium Chloride] results in decreased activity of POMC protein modified form; [Guanylyl Imidodiphosphate co-treated with Sodium Chloride] results in decreased activity of POMC protein modified form |
CTD |
PMID:2550106 |
|
NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
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G |
Ppp1r12a |
protein phosphatase 1, regulatory subunit 12A |
multiple interactions |
EXP |
[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in increased phosphorylation of PPP1R12A protein; atrasentan inhibits the reaction [[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in increased phosphorylation of PPP1R12A protein] |
CTD |
PMID:18823320 |
|
NCBI chr 7:51,404,971...51,515,382
Ensembl chr 7:51,404,919...51,515,373
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G |
Prkca |
protein kinase C, alpha |
increases expression |
ISO |
Sodium Chloride results in increased expression of PRKCA mRNA |
CTD |
PMID:23634900 |
|
NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
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G |
Ptgdr |
prostaglandin D2 receptor |
multiple interactions |
EXP |
[AGT protein co-treated with Sodium Chloride] affects the expression of PTGDR mRNA |
CTD |
PMID:27225954 |
|
NCBI chr15:19,195,606...19,196,508
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G |
Ptgds |
prostaglandin D2 synthase |
multiple interactions |
EXP |
[AGT protein co-treated with Sodium Chloride] affects the expression of PTGDS mRNA |
CTD |
PMID:27225954 |
|
NCBI chr 3:2,686,125...2,689,059
Ensembl chr 3:2,686,123...2,689,084
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G |
Ptges3 |
prostaglandin E synthase 3 |
multiple interactions |
EXP |
[AGT protein co-treated with Sodium Chloride] affects the expression of PTGES3 mRNA |
CTD |
PMID:27225954 |
|
NCBI chr 7:2,479,267...2,497,024
Ensembl chr 7:2,479,311...2,497,013
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G |
Ptgis |
prostaglandin I2 synthase |
multiple interactions |
EXP |
[AGT protein co-treated with Sodium Chloride] affects the expression of PTGIS mRNA |
CTD |
PMID:27225954 |
|
NCBI chr 3:163,950,746...163,986,129
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G |
Ptgs1 |
prostaglandin-endoperoxide synthase 1 |
multiple interactions |
EXP |
[AGT protein co-treated with Sodium Chloride] affects the expression of PTGS1 mRNA |
CTD |
PMID:27225954 |
|
NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions increases expression |
ISO EXP |
Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of PTGS2 protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [Sodium Chloride results in increased expression of PTGS2 protein]; diphenyleneiodonium inhibits the reaction [Sodium Chloride results in increased expression of PTGS2 protein]; Reactive Oxygen Species affects the reaction [Sodium Chloride results in increased expression of PTGS2 protein]; Rotenone inhibits the reaction [Sodium Chloride results in increased expression of PTGS2 protein]; TEMPO inhibits the reaction [Sodium Chloride results in increased expression of PTGS2 protein]; Thenoyltrifluoroacetone inhibits the reaction [Sodium Chloride results in increased expression of PTGS2 protein] Sodium Chloride deficiency results in increased expression of PTGS2 mRNA [Ramipril co-treated with Sodium Chloride deficiency] results in increased expression of PTGS2 protein; Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of PTGS2 mRNA] Sodium Chloride results in increased expression of PTGS2 mRNA; Sodium Chloride results in increased expression of PTGS2 protein |
CTD |
PMID:11832429 PMID:16024921 PMID:19782052 |
|
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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G |
Ptk2 |
protein tyrosine kinase 2 |
increases expression |
ISO |
Sodium Chloride results in increased expression of PTK2 mRNA |
CTD |
PMID:23634900 |
|
NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
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G |
Ptpn6 |
protein tyrosine phosphatase, non-receptor type 6 |
decreases expression |
ISO |
Sodium Chloride results in decreased expression of PTPN6 mRNA |
CTD |
PMID:23634900 |
|
NCBI chr 4:157,239,141...157,263,890
Ensembl chr 4:157,239,142...157,263,890
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G |
Rac1 |
Rac family small GTPase 1 |
increases activity multiple interactions |
ISO EXP |
Sodium Chloride results in increased activity of RAC1 protein [Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of RAC1 protein |
CTD |
PMID:15975986 PMID:22431579 |
|
NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
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|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
increases expression |
ISO |
Sodium Chloride results in increased expression of RELA mRNA |
CTD |
PMID:23634900 |
|
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Ren |
renin |
multiple interactions increases expression increases activity |
ISO EXP |
[Sodium Chloride deficiency co-treated with Enalapril] results in increased expression of REN mRNA; GJA5 affects the reaction [Sodium Chloride deficiency results in increased expression of REN mRNA]; REN enhancer mutant form results in decreased susceptibility to [Sodium Chloride deficiency co-treated with Enalapril] Sodium Chloride deficiency results in increased expression of REN mRNA; Sodium Chloride results in increased expression of REN1 protein Sodium Chloride deficiency results in increased activity of REN protein [Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of REN protein; Ramipril promotes the reaction [Sodium Chloride deficiency results in increased activity of REN protein]; Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of REN mRNA]; Sodium Chloride inhibits the reaction [Methylprednisolone results in increased activity of REN protein] |
CTD |
PMID:11039 PMID:235222 PMID:11832429 PMID:15134804 PMID:17846348 PMID:19474190 |
|
NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
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G |
Scnn1a |
sodium channel epithelial 1 subunit alpha |
multiple interactions increases expression |
EXP |
Quercetin inhibits the reaction [Sodium Chloride results in increased expression of SCNN1A mRNA] |
CTD |
PMID:14985096 |
|
NCBI chr 4:157,834,339...157,860,472
Ensembl chr 4:157,836,912...157,860,049
|
|
G |
Slc10a1 |
solute carrier family 10 member 1 |
multiple interactions |
ISO |
[Acetaminophen co-treated with Sodium Chloride] results in decreased expression of SLC10A1 mRNA |
CTD |
PMID:17934960 |
|
NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
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G |
Slc12a1 |
solute carrier family 12 member 1 |
affects transport decreases expression |
ISO |
SLC12A1 protein affects the transport of Sodium Chloride Sodium Chloride results in decreased expression of SLC12A1 mRNA |
CTD |
PMID:8617496 PMID:19782052 |
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NCBI chr 3:117,421,531...117,498,372
Ensembl chr 3:117,421,604...117,498,367
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G |
Slc26a5 |
solute carrier family 26 member 5 |
decreases expression |
EXP |
Sodium Chloride results in decreased expression of SLC26A5 mRNA |
CTD |
PMID:21624428 |
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NCBI chr 4:9,795,811...9,860,904
Ensembl chr 4:9,821,541...9,860,571
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G |
Slc2a1 |
solute carrier family 2 member 1 |
increases expression multiple interactions |
ISO EXP |
Sodium Chloride results in increased expression of SLC2A1 protein [Desoxycorticosterone Acetate co-treated with Sodium Chloride co-treated with cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester] results in increased expression of SLC2A1 protein |
CTD |
PMID:20025956 PMID:29621749 |
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NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
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G |
Slc2a4 |
solute carrier family 2 member 4 |
multiple interactions |
EXP |
[Desoxycorticosterone Acetate co-treated with Sodium Chloride co-treated with cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester] results in increased expression of SLC2A4 protein |
CTD |
PMID:29621749 |
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NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
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G |
Slc5a3 |
solute carrier family 5 member 3 |
multiple interactions increases expression |
ISO |
Allopurinol inhibits the reaction [Lipopolysaccharides inhibits the reaction [Sodium Chloride results in increased expression of SLC5A3 mRNA]]; Lipopolysaccharides inhibits the reaction [Sodium Chloride results in increased expression of SLC5A3 mRNA]; myxothiazol inhibits the reaction [Sodium Chloride results in increased expression of SLC5A3 mRNA] |
CTD |
PMID:23867654 |
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NCBI chr11:32,229,366...32,231,812
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G |
Slc6a12 |
solute carrier family 6 member 12 |
multiple interactions increases expression |
ISO |
myxothiazol inhibits the reaction [Sodium Chloride results in increased expression of SLC6A12 mRNA]; Rotenone inhibits the reaction [Sodium Chloride results in increased expression of SLC6A12 mRNA] Lipopolysaccharides inhibits the reaction [Sodium Chloride results in increased expression of SLC6A12 mRNA] |
CTD |
PMID:16303854 PMID:23867654 |
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NCBI chr 4:153,921,199...153,941,333
Ensembl chr 4:153,921,115...153,941,391
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G |
Slc9a1 |
solute carrier family 9 member A1 |
multiple interactions |
ISO |
[resveratrol results in increased expression of SLC9A1 protein] which results in increased uptake of Sodium Chloride |
CTD |
PMID:21191669 |
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NCBI chr 5:151,573,122...151,626,360
Ensembl chr 5:151,573,092...151,627,316
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G |
Slc9a3 |
solute carrier family 9 member A3 |
multiple interactions |
ISO |
[resveratrol results in increased expression of SLC9A3 protein] which results in increased uptake of Sodium Chloride |
CTD |
PMID:21191669 |
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NCBI chr 1:31,731,652...31,777,144
Ensembl chr 1:31,734,327...31,777,070
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G |
Slc9b2 |
solute carrier family 9 member B2 |
affects abundance |
ISO |
SLC9B2 protein affects the abundance of Sodium Chloride |
CTD |
PMID:18000046 |
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NCBI chr 2:240,485,254...240,519,166
Ensembl chr 2:240,495,371...240,519,141
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G |
Slco1b2 |
solute carrier organic anion transporter family member 1B2 |
multiple interactions |
ISO |
[Acetaminophen co-treated with Sodium Chloride] results in decreased expression of SLCO1B2 mRNA |
CTD |
PMID:17934960 |
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NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
EXP |
[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in decreased activity of SOD1 protein; [Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased activity of SOD1 protein; [Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of SOD1 protein; acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of SOD1 protein]; atrasentan inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of SOD1 protein]; Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in decreased activity of SOD1 protein]; Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased activity of SOD1 protein] |
CTD |
PMID:17616752 PMID:22431579 |
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NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions increases expression |
ISO EXP |
Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of SOD2 protein] [Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of SOD2 protein; acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of SOD2 protein]; atrasentan inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of SOD2 protein] |
CTD |
PMID:22431579 PMID:22718889 |
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NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
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G |
Sp1 |
Sp1 transcription factor |
multiple interactions |
EXP |
[[SP1 protein co-treated with JUN protein] binds to CLDN4 promoter] promotes the reaction [Sodium Chloride results in increased expression of CLDN4 protein] |
CTD |
PMID:23816505 |
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NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
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G |
Sult1a1 |
sulfotransferase family 1A member 1 |
multiple interactions |
ISO |
Sodium Chloride inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol] |
CTD |
PMID:11425650 PMID:15531517 |
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NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
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G |
Sv2c |
synaptic vesicle glycoprotein 2c |
multiple interactions |
ISO |
Sodium Chloride inhibits the reaction [Botulinum Toxins, Type A binds to [SV2C protein co-treated with trisialoganglioside GT1]] |
CTD |
PMID:30016653 |
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NCBI chr 2:26,495,757...26,707,691
Ensembl chr 2:26,501,833...26,699,333
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G |
Tgfb1 |
transforming growth factor, beta 1 |
increases expression multiple interactions |
ISO EXP |
Sodium Chloride results in increased expression of TGFB1 mRNA tempol inhibits the reaction [Sodium Chloride results in increased expression of TGFB1 protein] |
CTD |
PMID:20232302 PMID:26800359 |
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NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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G |
Tgfb2 |
transforming growth factor, beta 2 |
increases expression |
ISO |
Sodium Chloride results in increased expression of TGFB2 mRNA |
CTD |
PMID:26800359 |
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NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
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G |
Th |
tyrosine hydroxylase |
increases expression |
EXP |
Sodium Chloride results in increased expression of TH mRNA |
CTD |
PMID:10613505 |
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NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
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G |
Tjp1 |
tight junction protein 1 |
multiple interactions |
ISO |
[Desoxycorticosterone Acetate co-treated with Sodium Chloride] affects the localization of [NPHS2 protein co-treated with TJP1 protein]; CD38 gene mutant form promotes the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] affects the localization of [NPHS2 protein co-treated with TJP1 protein]] |
CTD |
PMID:21992601 |
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NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP ISO |
Sodium Chloride inhibits the reaction [Zymosan results in increased expression of TNF protein] [Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of TNF mRNA; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of TNF mRNA] |
CTD |
PMID:15834313 PMID:27678262 |
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NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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G |
Tp53 |
tumor protein p53 |
increases expression multiple interactions |
ISO EXP |
Sodium Chloride results in increased expression of TP53 mRNA Sodium Chloride results in increased phosphorylation of and affects the localization of TRP53 protein [Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of TP53 protein; acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of TP53 protein]; atrasentan inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of TP53 protein] |
CTD |
PMID:15975986 PMID:22431579 PMID:23634900 |
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NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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G |
Trpv1 |
transient receptor potential cation channel, subfamily V, member 1 |
multiple interactions affects response to substance increases expression |
ISO EXP |
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [resiniferatoxin inhibits the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester promotes the reaction [resiniferatoxin promotes the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; [Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein; Calcium Chloride inhibits the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; Ionomycin promotes the reaction [Calcium Chloride inhibits the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]]; resiniferatoxin inhibits the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]; resiniferatoxin promotes the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein] TRPV1 protein alternative form affects the susceptibility to Sodium Chloride Sodium Chloride results in increased expression of TRPV1 protein [Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein; Cyclosporine affects the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; Ionomycin inhibits the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; N-(3-methoxyphenyl)-4-chlorocinnamanilide inhibits the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]; Tacrolimus affects the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; Tetradecanoylphorbol Acetate affects the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]] |
CTD |
PMID:15146042 PMID:17984664 PMID:19553475 |
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NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
ISO |
[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of VCAM1 mRNA; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of VCAM1 mRNA] |
CTD |
PMID:27678262 |
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NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
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G |
Vegfa |
vascular endothelial growth factor A |
increases expression multiple interactions |
ISO |
Sodium Chloride results in increased expression of VEGFA mRNA 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [PD 173074 inhibits the reaction [Sodium Chloride results in increased expression of VEGFA mRNA]]; PD 173074 inhibits the reaction [Sodium Chloride results in increased expression of VEGFA mRNA] |
CTD |
PMID:23634900 PMID:26800359 |
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NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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G |
Vhl |
von Hippel-Lindau tumor suppressor |
increases expression |
ISO |
Sodium Chloride results in increased expression of VHL mRNA |
CTD |
PMID:23634900 |
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NCBI chr 4:145,580,869...145,587,835
Ensembl chr 4:145,580,799...145,587,845
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G |
Vim |
vimentin |
increases expression |
ISO |
Sodium Chloride results in increased expression of VIM mRNA |
CTD |
PMID:23634900 |
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NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
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