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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sodium chloride
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Accession:CHEBI:26710 term browser browse the term
Definition:An inorganic chloride salt having sodium(1+) as the counterion.
Synonyms:related_synonym: Formula=ClNa;   InChI=1S/ClH.Na/h1H;/q;+1/p-1;   InChIKey=FAPWRFPIFSIZLT-UHFFFAOYSA-M;   Kochsalz;   NaCl;   Natriumchlorid;   SMILES=[Na+].[Cl-];   chlorure de sodium;   cloruro sodico;   common salt;   halite;   natrii chloridum;   rock salt;   salt;   table salt
 xref: Beilstein:3534976;   CAS:7647-14-5;   Gmelin:13673;   KEGG:C13563;   KEGG:D02056
 xref_mesh: MESH:D012965
 xref: MetaCyc:NACL;   PPDB:595;   Reaxys:3534976;   Wikipedia:Sodium_Chloride



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sodium chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO [Acetaminophen co-treated with Sodium Chloride] results in decreased expression of ABCB11 mRNA CTD PMID:17934960 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO [Acetaminophen co-treated with Sodium Chloride] results in increased expression of ABCB1A mRNA CTD PMID:17934960 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B multiple interactions ISO [Acetaminophen co-treated with Sodium Chloride] results in increased expression of ABCB1B mRNA CTD PMID:17934960 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO [Acetaminophen co-treated with Sodium Chloride] results in increased expression of ABCC1 mRNA CTD PMID:17934960 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [Acetaminophen co-treated with Sodium Chloride] results in increased expression of ABCC2 mRNA CTD PMID:17934960 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO [Acetaminophen co-treated with Sodium Chloride] results in increased expression of ABCC3 mRNA CTD PMID:17934960 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO [Acetaminophen co-treated with Sodium Chloride] results in increased expression of ABCC4 mRNA CTD PMID:17934960 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Ace angiotensin I converting enzyme multiple interactions ISO ACE gene polymorphism affects the susceptibility to [Enalapril co-treated with Sodium Chloride]; ACE gene polymorphism inhibits the reaction [[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form] CTD PMID:20829712 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Agt angiotensinogen multiple interactions
increases expression
ISO
EXP
[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form; ACE gene polymorphism inhibits the reaction [[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form]
Sodium Chloride results in increased expression of AGT protein
[AGT protein co-treated with Sodium Chloride] affects the expression of ALOX5 mRNA; [AGT protein co-treated with Sodium Chloride] affects the expression of HPGDS mRNA; [AGT protein co-treated with Sodium Chloride] affects the expression of PLA2G4A mRNA; [AGT protein co-treated with Sodium Chloride] affects the expression of PLA2G4A protein; [AGT protein co-treated with Sodium Chloride] affects the expression of PTGDR mRNA; [AGT protein co-treated with Sodium Chloride] affects the expression of PTGDS mRNA; [AGT protein co-treated with Sodium Chloride] affects the expression of PTGES3 mRNA; [AGT protein co-treated with Sodium Chloride] affects the expression of PTGIS mRNA; [AGT protein co-treated with Sodium Chloride] affects the expression of PTGS1 mRNA; AGTR2 protein inhibits the reaction [Sodium Chloride results in increased activity of AGT protein]; Losartan inhibits the reaction [Sodium Chloride results in increased expression of AGT protein]
CTD PMID:15809360 PMID:20232302 PMID:20829712 PMID:27225954 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr2 angiotensin II receptor, type 2 decreases expression
multiple interactions
EXP Sodium Chloride results in decreased expression of AGTR2 mRNA; Sodium Chloride results in decreased expression of AGTR2 protein
AGTR2 protein inhibits the reaction [Sodium Chloride results in increased activity of AGT protein]
CTD PMID:15809360 NCBI chr  X:112,119,673...112,124,060
Ensembl chr  X:112,120,228...112,124,057
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 increases expression
multiple interactions
ISO Sodium Chloride results in increased expression of AKR1B3 mRNA
Lipopolysaccharides inhibits the reaction [Sodium Chloride results in increased expression of AKR1B3 mRNA]
CTD PMID:23867654 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions EXP [AGT protein co-treated with Sodium Chloride] affects the expression of ALOX5 mRNA CTD PMID:27225954 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO [[MPO protein co-treated with Hydrogen Peroxide co-treated with Sodium Chloride] results in increased oxidation of APOA1 protein] which results in decreased activity of LCAT protein; [MPO protein co-treated with Hydrogen Peroxide co-treated with Sodium Chloride] results in increased oxidation of APOA1 protein CTD PMID:33861588 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Arrb2 arrestin, beta 2 multiple interactions ISO Sodium Chloride affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- affects the localization of ARRB2 protein] CTD PMID:27030709 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions
decreases expression
EXP simendan inhibits the reaction [Sodium Chloride results in decreased expression of ATP2A2 mRNA] CTD PMID:17325658 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Avp arginine vasopressin increases expression ISO
EXP
Sodium Chloride results in increased expression of AVP protein
Sodium Chloride results in increased expression of AVP mRNA
CTD PMID:7923825 PMID:19463813 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP [Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of BAX protein; [Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of BAX protein; acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of BAX protein]; atrasentan inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of BAX protein] CTD PMID:16030430 PMID:22431579 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP [Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of BCL2 protein; [Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein; [S-allylcysteine co-treated with lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein]; acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of BCL2 protein]; atrasentan inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of BCL2 protein]; lycopene inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein]; S-allylcysteine inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein] CTD PMID:16030430 PMID:22431579 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l11 Bcl2-like 11 multiple interactions EXP [Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of BCL2L11 protein; S-allylcysteine inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of BCL2L11 protein] CTD PMID:16030430 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions
increases expression
ISO
EXP
[Sodium Chloride co-treated with Ethanol] results in increased expression of CALCA protein
Sodium Chloride promotes the reaction [arachidonyl dopamine results in increased expression of CALCA protein]; Sodium Chloride promotes the reaction [arachidonyl dopamine results in increased secretion of CALCA protein]
Sodium Chloride results in increased expression of CALCA protein
CTD PMID:17984664 PMID:18054007 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Capn1 calpain 1 multiple interactions ISO Sodium Chloride inhibits the reaction [Ethanol results in increased expression of CAPN1 protein] CTD PMID:33516933 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
JBrowse link
G Casp2 caspase 2 increases expression ISO Sodium Chloride results in increased expression of CASP2 mRNA CTD PMID:23634900 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
EXP
ISO
[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP3 protein; [S-allylcysteine co-treated with Lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP3 protein]
Sodium Chloride inhibits the reaction [Ethanol results in increased cleavage of CASP3 protein]
Sodium Chloride results in increased activity of CASP3 protein
CTD PMID:15975986 PMID:16030430 PMID:33516933 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases expression
multiple interactions
ISO
EXP
Sodium Chloride results in increased expression of CASP8 mRNA
[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein; [S-allylcysteine co-treated with lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]; lycopene inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]; S-allylcysteine inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]
CTD PMID:16030430 PMID:23634900 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Sodium Chloride results in increased expression of CCL2 mRNA CTD PMID:23634900 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression EXP Sodium Chloride results in increased expression of CCL5 protein CTD PMID:20232302 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Cd38 CD38 molecule multiple interactions ISO CD38 gene mutant form promotes the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] affects the localization of [NPHS2 protein co-treated with CDH3 protein]]; CD38 gene mutant form promotes the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] affects the localization of [NPHS2 protein co-treated with TJP1 protein]] CTD PMID:21992601 NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986
JBrowse link
G Cd68 Cd68 molecule multiple interactions ISO [Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CD68 mRNA; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CD68 mRNA] CTD PMID:27678262 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697
JBrowse link
G Cdh3 cadherin 3 multiple interactions ISO [Desoxycorticosterone Acetate co-treated with Sodium Chloride] affects the localization of [NPHS2 protein co-treated with CDH3 protein]; CD38 gene mutant form promotes the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] affects the localization of [NPHS2 protein co-treated with CDH3 protein]] CTD PMID:21992601 NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO Sodium Chloride results in decreased expression of CDKN1A mRNA CTD PMID:24211769 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression ISO Sodium Chloride results in increased expression of CEBPA mRNA CTD PMID:23634900 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cldn4 claudin 4 multiple interactions
increases expression
EXP [[SP1 protein co-treated with JUN protein] binds to CLDN4 promoter] promotes the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; diphenyleneiodonium inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]; diphenyleneiodonium inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]; Glutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; U 0126 inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]; U 0126 inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]
Sodium Chloride results in increased expression of CLDN4 mRNA; Sodium Chloride results in increased expression of CLDN4 protein
CTD PMID:23816505 NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Sodium Chloride results in increased expression of COL1A1 mRNA CTD PMID:23634900 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Cs citrate synthase multiple interactions EXP [Desoxycorticosterone Acetate co-treated with Sodium Chloride co-treated with cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester] results in increased expression of CS protein CTD PMID:29621749 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 multiple interactions ISO CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CD68 mRNA]; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CYBA mRNA]; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CYBB mRNA]; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of IL1B mRNA]; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of IL6 mRNA]; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of NOX1 mRNA]; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of NOX4 mRNA]; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of TNF mRNA]; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of VCAM1 mRNA] CTD PMID:27678262 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions EXP
ISO
[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of CYBA protein
[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CYBA mRNA; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CYBA mRNA]
CTD PMID:22431579 PMID:27678262 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO [Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CYBB mRNA; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CYBB mRNA] CTD PMID:27678262 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases expression
increases activity
EXP Sodium Chloride results in increased expression of CYP11B2 mRNA
Sodium Chloride results in increased activity of CYP11B2 protein
CTD PMID:15134804 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
JBrowse link
G Des desmin multiple interactions ISO [Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of DES protein CTD PMID:21992601 NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
JBrowse link
G Drd4 dopamine receptor D4 multiple interactions EXP NaCl inhibits the reaction [Quinpirole binds to Drd4 protein] RGD PMID:8078498 RGD:7248459 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP [19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in increased expression of EDN1 mRNA CTD PMID:18823320 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Ednra endothelin receptor type A multiple interactions ISO
EXP
[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] affects the activity of EDNRA protein
[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of EDNRA protein
CTD PMID:18516094 PMID:22431579 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP [19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in decreased expression of EDNRB mRNA; atrasentan inhibits the reaction [[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in decreased expression of EDNRB mRNA] CTD PMID:18823320 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases phosphorylation
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Sodium Chloride results in increased phosphorylation of EGFR protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Sodium Chloride results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [Sodium Chloride results in increased phosphorylation of EGFR protein]; Wortmannin inhibits the reaction [Sodium Chloride results in increased phosphorylation of EGFR protein] CTD PMID:21568938 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Egr1 early growth response 1 increases expression EXP Sodium Chloride results in increased expression of EGR1 CTD PMID:16280599 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
increases secretion
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Sodium Chloride results in increased expression of FGF2 mRNA]; 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Sodium Chloride results in increased secretion of FGF2 protein]; Apigenin inhibits the reaction [Sodium Chloride results in increased expression of FGF2 mRNA]; Dactinomycin inhibits the reaction [Sodium Chloride results in increased expression of FGF2 mRNA]; Luteolin inhibits the reaction [Sodium Chloride results in increased expression of FGF2 mRNA]; NFAT5 protein affects the reaction [Sodium Chloride results in increased expression of FGF2 mRNA]; NFAT5 protein affects the reaction [Sodium Chloride results in increased secretion of FGF2 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of FGF2 mRNA]; Quercetin inhibits the reaction [Sodium Chloride results in increased expression of FGF2 mRNA]; SB 203580 inhibits the reaction [Sodium Chloride results in increased expression of FGF2 mRNA] CTD PMID:26800359 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 increases expression EXP Sodium Chloride results in increased expression of FMO1 mRNA; Sodium Chloride results in increased expression of FMO1 protein CTD PMID:19429252 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP
ISO
Sodium Chloride results in increased expression of FOS mRNA CTD PMID:19463813 PMID:23634900 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Sodium Chloride results in increased expression of FOSL1 protein CTD PMID:20025956 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
JBrowse link
G Foxo1 forkhead box O1 decreases expression ISO Sodium Chloride results in decreased expression of FOXO1 mRNA CTD PMID:23634900 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
increases expression
EXP Sodium Chloride results in decreased expression of GFAP protein
Sodium Chloride results in increased expression of GFAP mRNA
CTD PMID:16280599 PMID:22954530 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Gja5 gap junction protein, alpha 5 multiple interactions ISO GJA5 affects the reaction [Sodium Chloride deficiency results in increased expression of REN mRNA] CTD PMID:19474190 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP [Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of GPX1 protein; acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of GPX1 protein]; atrasentan inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of GPX1 protein] CTD PMID:22431579 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Hbegf heparin-binding EGF-like growth factor multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA]; Apigenin inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA]; cyanidin inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA]; Dactinomycin inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA]; epigallocatechin gallate affects the reaction [Sodium Chloride results in increased expression of HBEGF mRNA]; Luteolin inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA]; myricetin affects the reaction [Sodium Chloride results in increased expression of HBEGF mRNA]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA]; Quercetin inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA]; SB 203580 inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA] CTD PMID:26800359 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression
EXP tempol inhibits the reaction [Sodium Chloride results in increased expression of HIF1A protein] CTD PMID:20232302 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Sodium Chloride results in increased expression of HMOX1 mRNA; Sodium Chloride results in increased expression of HMOX1 protein CTD PMID:11592956 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hpgds hematopoietic prostaglandin D synthase multiple interactions EXP [AGT protein co-treated with Sodium Chloride] affects the expression of HPGDS mRNA CTD PMID:27225954 NCBI chr 4:94,368,426...94,397,931
Ensembl chr 4:94,373,342...94,397,883
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases expression
decreases activity
EXP Sodium Chloride results in decreased expression of HSD11B2 mRNA
Sodium Chloride results in decreased activity of HSD11B2 protein
CTD PMID:12943734 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO Sodium Chloride results in increased expression of HSPA1B mRNA; Sodium Chloride results in increased expression of HSPA1B protein CTD PMID:12085988 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO Sodium Chloride results in increased expression of ICAM1 mRNA; Sodium Chloride results in increased expression of ICAM1 protein CTD PMID:11378323 PMID:23629852 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Sodium Chloride results in increased expression of IL1A mRNA CTD PMID:11378323 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
ISO Sodium Chloride results in increased expression of IL1B mRNA
[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of IL1B mRNA; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of IL1B mRNA]
CTD PMID:11378323 PMID:26800359 PMID:27678262 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO Sodium Chloride results in increased expression of IL6 mRNA
[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of IL6 mRNA; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of IL6 mRNA]; myxothiazol inhibits the reaction [Sodium Chloride inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; Rotenone inhibits the reaction [Sodium Chloride inhibits the reaction [Lipopolysaccharides promotes the reaction [NFAT5 protein binds to IL6 promoter]]]; Rotenone inhibits the reaction [Sodium Chloride inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; Rotenone inhibits the reaction [Sodium Chloride inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; Sodium Chloride inhibits the reaction [Lipopolysaccharides promotes the reaction [NFAT5 protein binds to IL6 promoter]]; Sodium Chloride inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Sodium Chloride inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD PMID:11378323 PMID:23634900 PMID:23867654 PMID:27678262 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [[SP1 protein co-treated with JUN protein] binds to CLDN4 promoter] promotes the reaction [Sodium Chloride results in increased expression of CLDN4 protein] CTD PMID:23816505 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kcnj1 potassium inwardly-rectifying channel, subfamily J, member 1 decreases expression ISO Sodium Chloride results in decreased expression of KCNJ1 mRNA CTD PMID:19782052 NCBI chr 8:30,779,883...30,808,607
Ensembl chr 8:30,753,617...30,813,796
JBrowse link
G Lcat lecithin cholesterol acyltransferase multiple interactions ISO [[MPO protein co-treated with Hydrogen Peroxide co-treated with Sodium Chloride] results in increased oxidation of APOA1 protein] which results in decreased activity of LCAT protein CTD PMID:33861588 NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]; Reactive Oxygen Species affects the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]; Sodium Chloride results in decreased phosphorylation of and results in decreased activity of MAPK1 protein
[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in increased phosphorylation of MAPK1 protein; atrasentan inhibits the reaction [[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in increased phosphorylation of MAPK1 protein]
CTD PMID:15975986 PMID:16024921 PMID:18823320 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Sodium Chloride results in increased phosphorylation of and results in increased activity of MAPK14 protein CTD PMID:15975986 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO
EXP
Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein]; Reactive Oxygen Species affects the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein]; Sodium Chloride results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in increased phosphorylation of MAPK3 protein; atrasentan inhibits the reaction [[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in increased phosphorylation of MAPK3 protein]
CTD PMID:15975986 PMID:16024921 PMID:18823320 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression ISO Sodium Chloride results in increased expression of MMP2 mRNA CTD PMID:23634900 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [[MPO protein co-treated with Hydrogen Peroxide co-treated with Sodium Chloride] results in increased oxidation of APOA1 protein] which results in decreased activity of LCAT protein; [MPO protein co-treated with Hydrogen Peroxide co-treated with Sodium Chloride] results in increased oxidation of APOA1 protein CTD PMID:33861588 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mt1 metallothionein 1 multiple interactions EXP [Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased expression of MT1A protein; Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased expression of MT1A protein] CTD PMID:17616752 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 multiple interactions
increases activity
affects localization
increases expression
ISO [Sodium Chloride results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFAT5 protein; Apigenin inhibits the reaction [Sodium Chloride results in increased expression of NFAT5 mRNA]; Luteolin inhibits the reaction [Sodium Chloride results in increased expression of NFAT5 mRNA]; myxothiazol inhibits the reaction [Sodium Chloride results in increased activity of NFAT5 protein]; NFAT5 protein affects the reaction [Sodium Chloride results in increased expression of FGF2 mRNA]; NFAT5 protein affects the reaction [Sodium Chloride results in increased secretion of FGF2 protein]; Quercetin inhibits the reaction [Sodium Chloride results in increased expression of NFAT5 mRNA]; Rotenone inhibits the reaction [Sodium Chloride results in increased activity of NFAT5 protein]
2-bromoethylamine inhibits the reaction [Sodium Chloride affects the localization of NFAT5 protein]; 2-bromoethylamine inhibits the reaction [Sodium Chloride results in increased expression of NFAT5 mRNA]; 2-bromoethylamine inhibits the reaction [Sodium Chloride results in increased expression of NFAT5 protein]; Lipopolysaccharides promotes the reaction [Sodium Chloride affects the localization of NFAT5 protein]; Lipopolysaccharides promotes the reaction [Sodium Chloride results in increased expression of NFAT5 mRNA]; Rotenone inhibits the reaction [Sodium Chloride inhibits the reaction [Lipopolysaccharides promotes the reaction [NFAT5 protein binds to IL6 promoter]]]; Sodium Chloride inhibits the reaction [Lipopolysaccharides promotes the reaction [NFAT5 protein binds to IL6 promoter]]; Sodium Chloride promotes the reaction [Lipopolysaccharides affects the localization of NFAT5 protein]; Sodium Chloride promotes the reaction [Lipopolysaccharides results in increased expression of NFAT5 mRNA]
Sodium Chloride results in increased expression of NFAT5 mRNA; Sodium Chloride results in increased expression of NFAT5 protein
CTD PMID:16303854 PMID:20823374 PMID:23867654 PMID:26800359 NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
increases expression
EXP [Ramipril co-treated with Sodium Chloride deficiency] results in increased expression of NOS1 protein; Metoprolol inhibits the reaction [[Ramipril co-treated with Sodium Chloride deficiency] results in increased expression of NOS1 protein]; Metoprolol inhibits the reaction [Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of NOS1 mRNA]]; Metoprolol inhibits the reaction [Sodium Chloride deficiency results in increased expression of NOS1 mRNA]; Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of NOS1 mRNA] CTD PMID:11832429 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases expression
EXP [19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in decreased expression of NOS3 protein; atrasentan inhibits the reaction [[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in decreased expression of NOS3 protein]; Losartan inhibits the reaction [Sodium Chloride results in decreased expression of NOS3 protein]; tempol inhibits the reaction [Sodium Chloride results in decreased expression of NOS3 protein] CTD PMID:18823320 PMID:20232302 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP
ISO
[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of NOX1 protein
[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of NOX1 mRNA; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of NOX1 mRNA]
CTD PMID:22431579 PMID:27678262 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO [Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of NOX4 mRNA; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of NOX4 mRNA] CTD PMID:27678262 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin decreases expression ISO Sodium chloride decreases expression of Nphs1 mRNA in hyperaldosteronic kidney RGD PMID:24108235 RGD:38599161 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078
JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions ISO [Desoxycorticosterone Acetate co-treated with Sodium Chloride] affects the localization of [NPHS2 protein co-treated with CDH3 protein]; [Desoxycorticosterone Acetate co-treated with Sodium Chloride] affects the localization of [NPHS2 protein co-treated with TJP1 protein]; [Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of NPHS2 protein; CD38 gene mutant form promotes the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] affects the localization of [NPHS2 protein co-treated with CDH3 protein]]; CD38 gene mutant form promotes the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] affects the localization of [NPHS2 protein co-treated with TJP1 protein]] CTD PMID:21992601 NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313
JBrowse link
G Nppa natriuretic peptide A increases expression
multiple interactions
EXP Sodium Chloride results in increased expression of NPPA mRNA
simendan inhibits the reaction [Sodium Chloride results in increased expression of NPPA mRNA]
CTD PMID:17325658 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nup88 nucleoporin 88 increases expression ISO Sodium Chloride results in increased expression of NUP88 protein CTD PMID:20823374 NCBI chr10:55,667,903...55,692,249
Ensembl chr10:55,667,906...55,692,257
JBrowse link
G Pdgfra platelet derived growth factor receptor alpha increases expression ISO Sodium Chloride results in increased expression of PDGFRA mRNA CTD PMID:23634900 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta increases expression ISO Sodium Chloride results in increased expression of PDGFRB mRNA CTD PMID:23634900 NCBI chr18:54,500,002...54,538,843
Ensembl chr18:54,499,964...54,538,843
JBrowse link
G Pdhx pyruvate dehydrogenase complex, component X multiple interactions EXP [Desoxycorticosterone Acetate co-treated with Sodium Chloride co-treated with cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester] results in increased expression of PDHX protein; [Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of PDHX protein CTD PMID:29621749 NCBI chr 3:89,372,472...89,396,759
Ensembl chr 3:89,371,497...89,431,773
JBrowse link
G Pgr progesterone receptor increases activity ISO Sodium Chloride results in increased activity of PGR protein CTD PMID:9879984 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Pla2g4a phospholipase A2 group IVA increases expression
multiple interactions
ISO
EXP
Sodium Chloride results in increased expression of PLA2G4A mRNA
[AGT protein co-treated with Sodium Chloride] affects the expression of PLA2G4A mRNA; [AGT protein co-treated with Sodium Chloride] affects the expression of PLA2G4A protein
CTD PMID:23634900 PMID:27225954 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Pomc proopiomelanocortin multiple interactions ISO [Guanosine Triphosphate co-treated with Sodium Chloride] results in decreased activity of POMC protein modified form; [Guanylyl Imidodiphosphate co-treated with Sodium Chloride] results in decreased activity of POMC protein modified form CTD PMID:2550106 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A multiple interactions EXP [19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in increased phosphorylation of PPP1R12A protein; atrasentan inhibits the reaction [[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in increased phosphorylation of PPP1R12A protein] CTD PMID:18823320 NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425
JBrowse link
G Prkca protein kinase C, alpha increases expression ISO Sodium Chloride results in increased expression of PRKCA mRNA CTD PMID:23634900 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Ptgdr prostaglandin D2 receptor multiple interactions EXP [AGT protein co-treated with Sodium Chloride] affects the expression of PTGDR mRNA CTD PMID:27225954 NCBI chr15:17,360,304...17,367,679
Ensembl chr15:17,360,304...17,367,679
JBrowse link
G Ptgds prostaglandin D2 synthase multiple interactions EXP [AGT protein co-treated with Sodium Chloride] affects the expression of PTGDS mRNA CTD PMID:27225954 NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833
JBrowse link
G Ptges3 prostaglandin E synthase 3 multiple interactions EXP [AGT protein co-treated with Sodium Chloride] affects the expression of PTGES3 mRNA CTD PMID:27225954 NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084
JBrowse link
G Ptgis prostaglandin I2 synthase multiple interactions EXP [AGT protein co-treated with Sodium Chloride] affects the expression of PTGIS mRNA CTD PMID:27225954 NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions EXP [AGT protein co-treated with Sodium Chloride] affects the expression of PTGS1 mRNA CTD PMID:27225954 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO
EXP
Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of PTGS2 protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [Sodium Chloride results in increased expression of PTGS2 protein]; diphenyleneiodonium inhibits the reaction [Sodium Chloride results in increased expression of PTGS2 protein]; Reactive Oxygen Species affects the reaction [Sodium Chloride results in increased expression of PTGS2 protein]; Rotenone inhibits the reaction [Sodium Chloride results in increased expression of PTGS2 protein]; TEMPO inhibits the reaction [Sodium Chloride results in increased expression of PTGS2 protein]; Thenoyltrifluoroacetone inhibits the reaction [Sodium Chloride results in increased expression of PTGS2 protein]
Sodium Chloride deficiency results in increased expression of PTGS2 mRNA
[Ramipril co-treated with Sodium Chloride deficiency] results in increased expression of PTGS2 protein; Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of PTGS2 mRNA]
Sodium Chloride results in increased expression of PTGS2 mRNA; Sodium Chloride results in increased expression of PTGS2 protein
CTD PMID:11832429 PMID:16024921 PMID:19782052 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptk2 protein tyrosine kinase 2 increases expression ISO Sodium Chloride results in increased expression of PTK2 mRNA CTD PMID:23634900 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 decreases expression ISO Sodium Chloride results in decreased expression of PTPN6 mRNA CTD PMID:23634900 NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984
JBrowse link
G Rac1 Rac family small GTPase 1 increases activity
multiple interactions
ISO
EXP
Sodium Chloride results in increased activity of RAC1 protein
[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of RAC1 protein
CTD PMID:15975986 PMID:22431579 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression ISO Sodium Chloride results in increased expression of RELA mRNA CTD PMID:23634900 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Ren renin multiple interactions
increases expression
increases activity
ISO
EXP
[Sodium Chloride deficiency co-treated with Enalapril] results in increased expression of REN mRNA; GJA5 affects the reaction [Sodium Chloride deficiency results in increased expression of REN mRNA]; REN enhancer mutant form results in decreased susceptibility to [Sodium Chloride deficiency co-treated with Enalapril]
Sodium Chloride deficiency results in increased expression of REN mRNA; Sodium Chloride results in increased expression of REN1 protein
Sodium Chloride deficiency results in increased activity of REN protein
[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of REN protein; Ramipril promotes the reaction [Sodium Chloride deficiency results in increased activity of REN protein]; Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of REN mRNA]; Sodium Chloride inhibits the reaction [Methylprednisolone results in increased activity of REN protein]
CTD PMID:11039 PMID:235222 PMID:11832429 PMID:15134804 PMID:17846348 More... NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha multiple interactions
increases expression
EXP Quercetin inhibits the reaction [Sodium Chloride results in increased expression of SCNN1A mRNA] CTD PMID:14985096 NCBI chr 4:158,122,962...158,146,184
Ensembl chr 4:158,122,962...158,146,181
JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions ISO [Acetaminophen co-treated with Sodium Chloride] results in decreased expression of SLC10A1 mRNA CTD PMID:17934960 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slc12a1 solute carrier family 12 member 1 affects transport
decreases expression
ISO SLC12A1 protein affects the transport of Sodium Chloride
Sodium Chloride results in decreased expression of SLC12A1 mRNA
CTD PMID:8617496 PMID:19782052 NCBI chr 3:112,406,140...112,482,913
Ensembl chr 3:112,406,140...112,482,899
JBrowse link
G Slc26a5 solute carrier family 26 member 5 decreases expression EXP Sodium Chloride results in decreased expression of SLC26A5 mRNA CTD PMID:21624428 NCBI chr 4:13,210,260...13,249,289
Ensembl chr 4:13,210,260...13,249,289
JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression
multiple interactions
ISO
EXP
Sodium Chloride results in increased expression of SLC2A1 protein
[Desoxycorticosterone Acetate co-treated with Sodium Chloride co-treated with cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester] results in increased expression of SLC2A1 protein
CTD PMID:20025956 PMID:29621749 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP [Desoxycorticosterone Acetate co-treated with Sodium Chloride co-treated with cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester] results in increased expression of SLC2A4 protein CTD PMID:29621749 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Slc5a3 solute carrier family 5 member 3 multiple interactions
increases expression
ISO Allopurinol inhibits the reaction [Lipopolysaccharides inhibits the reaction [Sodium Chloride results in increased expression of SLC5A3 mRNA]]; Lipopolysaccharides inhibits the reaction [Sodium Chloride results in increased expression of SLC5A3 mRNA]; myxothiazol inhibits the reaction [Sodium Chloride results in increased expression of SLC5A3 mRNA] CTD PMID:23867654 NCBI chr11:31,313,847...31,316,293
Ensembl chr11:31,295,476...31,318,883
JBrowse link
G Slc6a12 solute carrier family 6 member 12 multiple interactions
increases expression
ISO myxothiazol inhibits the reaction [Sodium Chloride results in increased expression of SLC6A12 mRNA]; Rotenone inhibits the reaction [Sodium Chloride results in increased expression of SLC6A12 mRNA]
Lipopolysaccharides inhibits the reaction [Sodium Chloride results in increased expression of SLC6A12 mRNA]
CTD PMID:16303854 PMID:23867654 NCBI chr 4:154,585,386...154,603,750
Ensembl chr 4:154,585,500...154,603,750
JBrowse link
G Slc8a3 solute carrier family 8 member A3 multiple interactions ISO Sodium Chloride promotes the reaction [Ethanol results in increased expression of SLC8A3 protein] CTD PMID:33516933 NCBI chr 6:100,874,359...101,007,989
Ensembl chr 6:100,874,369...101,007,508
JBrowse link
G Slc9a1 solute carrier family 9 member A1 multiple interactions ISO [resveratrol results in increased expression of SLC9A1 protein] which results in increased uptake of Sodium Chloride CTD PMID:21191669 NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624
JBrowse link
G Slc9a3 solute carrier family 9 member A3 multiple interactions ISO [resveratrol results in increased expression of SLC9A3 protein] which results in increased uptake of Sodium Chloride CTD PMID:21191669 NCBI chr 1:29,124,633...29,167,912
Ensembl chr 1:29,124,674...29,167,417
JBrowse link
G Slc9b2 solute carrier family 9 member B2 affects abundance ISO SLC9B2 protein affects the abundance of Sodium Chloride CTD PMID:18000046 NCBI chr 2:223,726,982...223,761,234
Ensembl chr 2:223,736,354...223,761,225
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO [Acetaminophen co-treated with Sodium Chloride] results in decreased expression of SLCO1B2 mRNA CTD PMID:17934960 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP [Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in decreased activity of SOD1 protein; [Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased activity of SOD1 protein; [Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of SOD1 protein; acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of SOD1 protein]; atrasentan inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of SOD1 protein]; Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in decreased activity of SOD1 protein]; Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased activity of SOD1 protein] CTD PMID:17616752 PMID:22431579 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO
EXP
Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of SOD2 protein]
[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of SOD2 protein; acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of SOD2 protein]; atrasentan inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of SOD2 protein]
CTD PMID:22431579 PMID:22718889 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions EXP [[SP1 protein co-treated with JUN protein] binds to CLDN4 promoter] promotes the reaction [Sodium Chloride results in increased expression of CLDN4 protein] CTD PMID:23816505 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions ISO Sodium Chloride inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol] CTD PMID:11425650 PMID:15531517 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Sv2c synaptic vesicle glycoprotein 2c multiple interactions ISO Sodium Chloride inhibits the reaction [Botulinum Toxins, Type A binds to [SV2C protein co-treated with trisialoganglioside GT1]] CTD PMID:30016653 NCBI chr 2:27,232,933...27,428,479
Ensembl chr 2:27,232,933...27,428,477
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions
ISO
EXP
Sodium Chloride results in increased expression of TGFB1 mRNA
tempol inhibits the reaction [Sodium Chloride results in increased expression of TGFB1 protein]
CTD PMID:20232302 PMID:26800359 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression ISO Sodium Chloride results in increased expression of TGFB2 mRNA CTD PMID:26800359 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Th tyrosine hydroxylase increases expression EXP Sodium Chloride results in increased expression of TH mRNA CTD PMID:10613505 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO [Desoxycorticosterone Acetate co-treated with Sodium Chloride] affects the localization of [NPHS2 protein co-treated with TJP1 protein]; CD38 gene mutant form promotes the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] affects the localization of [NPHS2 protein co-treated with TJP1 protein]] CTD PMID:21992601 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
Sodium Chloride inhibits the reaction [Zymosan results in increased expression of TNF protein]
[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of TNF mRNA; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of TNF mRNA]
CTD PMID:15834313 PMID:27678262 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO
EXP
Sodium Chloride results in increased expression of TP53 mRNA
Sodium Chloride results in increased phosphorylation of and affects the localization of TRP53 protein
[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of TP53 protein; acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of TP53 protein]; atrasentan inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of TP53 protein]
CTD PMID:15975986 PMID:22431579 PMID:23634900 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
affects response to substance
increases expression
ISO
EXP
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [resiniferatoxin inhibits the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester promotes the reaction [resiniferatoxin promotes the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; [Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein; Calcium Chloride inhibits the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; Ionomycin promotes the reaction [Calcium Chloride inhibits the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]]; resiniferatoxin inhibits the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]; resiniferatoxin promotes the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]
TRPV1 protein alternative form affects the susceptibility to Sodium Chloride
Sodium Chloride results in increased expression of TRPV1 protein
[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein; Cyclosporine affects the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; Ionomycin inhibits the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; N-(3-methoxyphenyl)-4-chlorocinnamanilide inhibits the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]; Tacrolimus affects the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; Tetradecanoylphorbol Acetate affects the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]
CTD PMID:15146042 PMID:17984664 PMID:19553475 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO [Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of VCAM1 mRNA; CXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of VCAM1 mRNA] CTD PMID:27678262 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions
ISO Sodium Chloride results in increased expression of VEGFA mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [PD 173074 inhibits the reaction [Sodium Chloride results in increased expression of VEGFA mRNA]]; PD 173074 inhibits the reaction [Sodium Chloride results in increased expression of VEGFA mRNA]
CTD PMID:23634900 PMID:26800359 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vhl von Hippel-Lindau tumor suppressor increases expression ISO Sodium Chloride results in increased expression of VHL mRNA CTD PMID:23634900 NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377
JBrowse link
G Vim vimentin increases expression ISO Sodium Chloride results in increased expression of VIM mRNA CTD PMID:23634900 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      application 19781
        flame retardant 4983
          sodium chloride 129
            halite 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      halogen 18546
                        chlorine atom 18335
                          chlorine molecular entity 18309
                            elemental chlorine 8473
                              monoatomic chlorine 8447
                                chloride 8447
                                  chloride salt 8447
                                    inorganic chloride 8284
                                      sodium chloride 129
                                        halite 0
paths to the root