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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sodium hydrogensulfite
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Accession:CHEBI:26709 term browser browse the term
Definition:An inorganic sodium salt having hydrogensulfite as the counterion.
Synonyms:related_synonym: E 222;   E222;   Formula=HNaO3S;   InChI=1S/Na.H2O3S/c;1-4(2)3/h;(H2,1,2,3)/q+1;/p-1;   InChIKey=DWAQJAXMDSEUJJ-UHFFFAOYSA-M;   NaHSO3;   Natriumbisulfit;   Natriumhydrogensulfit;   SMILES=[Na+].OS([O-])=O;   primaeres Natriumsulfit;   saures Natriumsulfit;   sodium bisulfite;   sodium bisulphite;   sodium hydrogen sulfite;   sulfurous acid monosodium salt;   sulfurous acid sodium salt;   sulfurous acid, sodium salt (1:1)
 xref: AGR:IND605265115;   CAS:7631-90-5;   DrugBank:DB14015;   FooDB:FDB015420;   Gmelin:22395;   KEGG:D02059
 xref_mesh: MESH:C009279
 xref: PMID:27905861;   PMID:30429859;   PMID:32714086;   PMID:32785935;   PMID:35114314;   PMID:36440381;   Wikipedia:Sodium_bisulfite


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sodium hydrogensulfite term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 multiple interactions ISO 6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]; [sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein; Ascorbic Acid inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]; Dizocilpine Maleate inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]; KT 5720 inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]; PTGS2 protein affects the susceptibility to [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]; Vitamin E inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein] CTD PMID:21873648 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G COX4I1 cytochrome c oxidase subunit 4I1 decreases expression ISO sodium bisulfite results in decreased expression of COX4 mRNA CTD PMID:26980303 NCBI chr16:85,799,695...85,807,068
Ensembl chr16:85,798,633...85,807,068 		JBrowse link
G MT-ATP6 mitochondrially encoded ATP synthase membrane subunit 6 decreases expression ISO sodium bisulfite results in decreased expression of ATP6 mRNA CTD PMID:26980303 NCBI chr MT:8,527...9,207
Ensembl chr MT:8,527...9,207 		JBrowse link
G MT-ATP8 mitochondrially encoded ATP synthase membrane subunit 8 multiple interactions
decreases expression		 ISO Acetylcysteine inhibits the reaction [sodium bisulfite results in decreased expression of ATP8 mRNA] CTD PMID:26980303 NCBI chr MT:8,366...8,572
Ensembl chr MT:8,366...8,572 		JBrowse link
G MT-CO1 mitochondrially encoded cytochrome c oxidase I multiple interactions
decreases expression		 ISO Acetylcysteine inhibits the reaction [sodium bisulfite results in decreased expression of COX1 mRNA] CTD PMID:26980303 NCBI chr MT:5,904...7,445
Ensembl chr MT:5,904...7,445 		JBrowse link
G MT-CO2 mitochondrially encoded cytochrome c oxidase II decreases expression ISO sodium bisulfite results in decreased expression of COX2 mRNA CTD PMID:26980303 NCBI chr MT:7,586...8,269
Ensembl chr MT:7,586...8,269 		JBrowse link
G MT-CO3 mitochondrially encoded cytochrome c oxidase III multiple interactions
decreases expression		 ISO TFAM protein inhibits the reaction [sodium bisulfite results in decreased expression of COX3 mRNA] CTD PMID:26980303 NCBI chr MT:9,207...9,990
Ensembl chr MT:9,207...9,990 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO sodium bisulfite inhibits the reaction [Rotenone results in increased expression of NOS2 mRNA] CTD PMID:25086357 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NRF1 nuclear respiratory factor 1 multiple interactions
decreases expression		 ISO Acetylcysteine inhibits the reaction [sodium bisulfite results in decreased expression of NRF1 mRNA]
sodium bisulfite results in decreased expression of NRF1 mRNA; sodium bisulfite results in decreased expression of NRF1 protein		 CTD PMID:26980303 NCBI chr 7:129,611,720...129,757,076
Ensembl chr 7:129,611,720...129,757,082 		JBrowse link
G PPARGC1A PPARG coactivator 1 alpha multiple interactions
decreases expression		 ISO Acetylcysteine inhibits the reaction [sodium bisulfite results in decreased expression of PPARGC1A mRNA]
sodium bisulfite results in decreased expression of PPARGC1A mRNA; sodium bisulfite results in decreased expression of PPARGC1A protein		 CTD PMID:26980303 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089 		JBrowse link
G PTGER2 prostaglandin E receptor 2 multiple interactions ISO [sodium bisulfite co-treated with sodium sulfite] results in increased expression of PTGER2 protein CTD PMID:21873648 NCBI chr14:52,314,312...52,328,598
Ensembl chr14:52,314,305...52,328,598 		JBrowse link
G PTGER4 prostaglandin E receptor 4 multiple interactions ISO [sodium bisulfite co-treated with sodium sulfite] results in increased expression of PTGER4 protein CTD PMID:21873648 NCBI chr 5:40,679,915...40,746,800
Ensembl chr 5:40,679,915...40,693,735 		JBrowse link
G PTGES prostaglandin E synthase multiple interactions ISO [sodium bisulfite co-treated with sodium sulfite] results in increased expression of PTGES mRNA CTD PMID:21873648 NCBI chr 9:129,738,349...129,753,042
Ensembl chr 9:129,738,331...129,753,042 		JBrowse link
G PTGES2 prostaglandin E synthase 2 multiple interactions ISO [sodium bisulfite co-treated with sodium sulfite] results in increased expression of PTGES2 mRNA CTD PMID:21873648 NCBI chr 9:128,120,693...128,128,440
Ensembl chr 9:128,120,693...128,128,462 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO [SC 560 results in decreased activity of PTGS1 protein] promotes the reaction [[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased abundance of Dinoprostone]] CTD PMID:21873648 NCBI chr 9:122,370,533...122,395,703
Ensembl chr 9:122,370,530...122,395,703 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased abundance of Cyclic AMP]; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased abundance of Dinoprostone]; [SC 560 results in decreased activity of PTGS1 protein] promotes the reaction [[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased abundance of Dinoprostone]]; [sodium bisulfite co-treated with sodium sulfite] results in increased expression of PTGS2 protein; Ascorbic Acid inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased expression of PTGS2 protein]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased expression of PTGS2 protein]; PTGS2 protein affects the susceptibility to [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]; Vitamin E inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased expression of PTGS2 protein]
sodium bisulfite inhibits the reaction [Rotenone results in increased expression of PTGS2 mRNA]; sodium bisulfite inhibits the reaction [Rotenone results in increased expression of PTGS2 protein]		 CTD PMID:21873648 PMID:25086357 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G TFAM transcription factor A, mitochondrial multiple interactions
decreases expression		 ISO Acetylcysteine inhibits the reaction [sodium bisulfite results in decreased expression of TFAM mRNA]; TFAM protein inhibits the reaction [sodium bisulfite results in decreased expression of COX3 mRNA]
sodium bisulfite results in decreased expression of TFAM mRNA; sodium bisulfite results in decreased expression of TFAM protein		 CTD PMID:26980303 NCBI chr10:58,385,410...58,399,220
Ensembl chr10:58,385,345...58,399,220 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO sodium bisulfite inhibits the reaction [Rotenone results in increased expression of TNF mRNA] CTD PMID:25086357 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      chemical role 24242
        reducing agent 224
          sodium hydrogensulfite 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      chalcogen 24917
                        oxygen atom 24817
                          oxygen molecular entity 24806
                            hydroxides 24049
                              oxoacid 22975
                                oxoacid derivative 16736
                                  sulfur oxoacid derivative 14882
                                    sulfurous acid derivative 4387
                                      sulfites 4387
                                        sulfite salt 22
                                          sodium hydrogensulfite 18
paths to the root