Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:amlodipine
go back to main search page
Accession:CHEBI:2668 term browser browse the term
Definition:A fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.
Synonyms:exact_synonym: 3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
 related_synonym: 3-Ethyl-5-methyl (+-)-2-(2-aminoethoxymethyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate;   Amlodipine Free Base;   Formula=C20H25ClN2O5;   InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3;   InChIKey=HTIQEAQVCYTUBX-UHFFFAOYSA-N;   SMILES=CCOC(=O)C1=C(COCCN)NC(C)=C(C1c1ccccc1Cl)C(=O)OC;   amlodipino;   amlodipinum
 xref: CAS:88150-42-9;   DrugBank:DB00381;   Drug_Central:183;   KEGG:C06825;   KEGG:D07450;   LINCS:LSM-1388
 xref_mesh: MESH:D017311
 xref: PMID:1532771;   PMID:16422032;   PMID:1834846;   PMID:19450066;   PMID:21591999;   PMID:7522286;   PMID:8310972;   PMID:8310973;   PMID:9156957;   Patent:EP89167;   Patent:US4572909;   Reaxys:3570229;   VSDB:2963;   Wikipedia:Amlodipine


show annotations for term's descendants           Sort by:
amlodipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases expression EXP Amlodipine results in decreased expression of ACE mRNA CTD PMID:16392774 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO Amlodipine results in increased expression of ADIPOQ; Amlodipine results in increased expression of ADIPOQ protein CTD PMID:18199500 PMID:19059660 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169 		JBrowse link
G Agt angiotensinogen multiple interactions ISO Amlodipine inhibits the reaction [AGT results in decreased expression of BCL2 mRNA]; Amlodipine inhibits the reaction [AGT results in decreased expression of BCL2 protein]; Amlodipine inhibits the reaction [AGT results in increased expression of BAX mRNA]; Amlodipine inhibits the reaction [AGT results in increased expression of BAX protein]; Amlodipine inhibits the reaction [AGT results in increased expression of OLR1 mRNA]; Amlodipine inhibits the reaction [AGT results in increased expression of OLR1 protein] CTD PMID:21376258 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression EXP Amlodipine results in decreased expression of AGTR1A mRNA CTD PMID:18403896 NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 decreases expression EXP Amlodipine results in decreased expression of AGTR2 mRNA CTD PMID:18403896 NCBI chr  X:116,914,320...116,918,504
Ensembl chr  X:116,913,656...116,918,745 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP 		Amlodipine inhibits the reaction [AGT results in increased expression of BAX mRNA]; Amlodipine inhibits the reaction [AGT results in increased expression of BAX protein]; Amlodipine inhibits the reaction [Iohexol results in increased expression of BAX protein]
Amlodipine inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; Amlodipine inhibits the reaction [Gentamicins results in increased expression of BAX protein]; Amlodipine inhibits the reaction [Iohexol results in increased expression of BAX protein] 		CTD PMID:17234320 PMID:19698708 PMID:21376258 PMID:36207783 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP 		Amlodipine inhibits the reaction [AGT results in decreased expression of BCL2 mRNA]; Amlodipine inhibits the reaction [AGT results in decreased expression of BCL2 protein]; Amlodipine inhibits the reaction [Iohexol results in decreased expression of BCL2 protein]
Amlodipine inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Amlodipine inhibits the reaction [Gentamicins results in decreased expression of BCL2 protein]; Amlodipine inhibits the reaction [Iohexol results in decreased expression of BCL2 protein] 		CTD PMID:17234320 PMID:19698708 PMID:21376258 PMID:36207783 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bdkrb2 bradykinin receptor B2 increases response to substance ISO BDKRB2 results in increased susceptibility to Amlodipine CTD PMID:10523327 NCBI chr 6:130,237,055...130,267,205
Ensembl chr 6:130,237,255...130,267,209 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases cleavage
increases cleavage 		ISO
EXP 		[Amlodipine co-treated with Topotecan] results in increased activity of CASP3 protein; Amlodipine inhibits the reaction [Iohexol results in increased cleavage of CASP3 protein]
Amlodipine results in decreased cleavage of CASP3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [soybean oil, phospholipid emulsion inhibits the reaction [Amlodipine results in increased cleavage of CASP3 protein]]; Amlodipine inhibits the reaction [Iohexol results in increased cleavage of CASP3 protein]; Glyburide inhibits the reaction [soybean oil, phospholipid emulsion inhibits the reaction [Amlodipine results in increased cleavage of CASP3 protein]]; soybean oil, phospholipid emulsion inhibits the reaction [Amlodipine results in increased cleavage of CASP3 protein] 		CTD PMID:16516327 PMID:17563544 PMID:33030052 PMID:36207783 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO [Amlodipine co-treated with Topotecan] results in increased activity of CASP7 protein CTD PMID:16516327 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage 		ISO
EXP 		[Amlodipine co-treated with Topotecan] results in increased activity of CASP8 protein
Amlodipine results in increased cleavage of CASP8 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [soybean oil, phospholipid emulsion inhibits the reaction [Amlodipine results in increased cleavage of CASP8 protein]]; soybean oil, phospholipid emulsion inhibits the reaction [Amlodipine results in increased cleavage of CASP8 protein] 		CTD PMID:16516327 PMID:33030052 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP Glyburide inhibits the reaction [soybean oil, phospholipid emulsion inhibits the reaction [Amlodipine results in increased cleavage of CASP9 protein]] CTD PMID:33030052 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression EXP Amlodipine results in decreased expression of CCL2 mRNA CTD PMID:16392774 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Amlodipine results in decreased activity of and results in decreased expression of CCND1 protein CTD PMID:17217918 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Ccne1 cyclin E1 decreases activity ISO Amlodipine results in decreased activity of CCNE1 protein CTD PMID:17217918 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity ISO Amlodipine results in decreased activity of CDK2 protein CTD PMID:17217918 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO Amlodipine results in decreased activity of and results in decreased expression of CDK4 protein CTD PMID:17217918 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Amlodipine results in increased expression of CDKN1A protein CTD PMID:17217918 PMID:18298949 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression EXP Amlodipine results in decreased expression of COL1A1 mRNA CTD PMID:9449387 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions EXP Amlodipine inhibits the reaction [Nitric Oxide deficiency results in increased expression of COL1A2 mRNA] CTD PMID:10445667 NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:33,518,420...33,553,995 		JBrowse link
G Crp C-reactive protein multiple interactions ISO [Atorvastatin co-treated with Amlodipine] results in decreased expression of CRP protein CTD PMID:18389332 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514 		JBrowse link
G Ctsd cathepsin D multiple interactions EXP [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]; [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:11829124 PMID:14499179 NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821 		JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions EXP Amlodipine promotes the reaction [candesartan results in decreased expression of CYBA] CTD PMID:21107329 NCBI chr19:67,396,143...67,404,214
Ensembl chr19:67,396,143...67,404,214 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP Amlodipine promotes the reaction [candesartan results in decreased expression of CYBB] CTD PMID:21107329 NCBI chr  X:16,030,596...16,065,065
Ensembl chr  X:16,030,596...16,065,065 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression EXP Amlodipine results in decreased expression of CYP11A1 mRNA CTD PMID:11086231 NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:67,270,556...67,330,196 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Amlodipine results in decreased activity of CYP19A1 protein CTD PMID:26141389 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Amlodipine results in decreased activity of CYP1A1 protein CTD PMID:10805063 PMID:33814510 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Amlodipine results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity ISO Amlodipine results in decreased activity of CYP2B6 protein CTD PMID:10805063 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO Amlodipine results in decreased activity of CYP2J2 protein CTD PMID:30965050 NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:116,295,694...116,323,042 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO Amlodipine results in decreased activity of CYP3A4 protein CTD PMID:39023798 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects response to substance ISO CYP3A5 gene affects the susceptibility to Amlodipine CTD PMID:22149319 NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154 		JBrowse link
G Drd1 dopamine receptor D1 multiple interactions ISO Amlodipine inhibits the reaction [SCH 23390 binds to DRD1 protein] CTD PMID:9533112 NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,545,111...10,567,166 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO Amlodipine inhibits the reaction [Raclopride binds to DRD2 protein] CTD PMID:9533112 NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339 		JBrowse link
G Edn1 endothelin 1 affects expression ISO Amlodipine affects the expression of EDN1 protein CTD PMID:11369837 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687 		JBrowse link
G Gal galanin and GMAP prepropeptide multiple interactions EXP [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of GAL protein]; [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of GAL protein] CTD PMID:11829124 PMID:14499179 NCBI chr 1:210,079,709...210,084,572
Ensembl chr 1:210,079,702...210,084,229 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Amlodipine inhibits the reaction [Acetaminophen results in increased activity of GPT protein] CTD PMID:29441826 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP Amlodipine results in decreased activity of GSR protein CTD PMID:17710547 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Gusb glucuronidase, beta multiple interactions EXP [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] CTD PMID:11829124 PMID:14499179 NCBI chr12:32,337,281...32,350,838
Ensembl chr12:32,334,075...32,363,024 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP Amlodipine inhibits the reaction [Iohexol results in increased expression of HAVCR1 protein] CTD PMID:36207783 NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions EXP Amlodipine inhibits the reaction [Fructose results in increased expression of HSPD1 protein] CTD PMID:18948349 NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression 		EXP Amlodipine inhibits the reaction [Diclofenac results in decreased expression of ICAM1 protein]
Amlodipine results in decreased expression of ICAM1 protein 		CTD PMID:18460984 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Ins2 insulin 2 decreases expression ISO Amlodipine results in decreased expression of INS protein CTD PMID:19651449 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805 		JBrowse link
G Jak2 Janus kinase 2 increases expression ISO Amlodipine results in increased expression of JAK2 protein modified form CTD PMID:18298949 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762 		JBrowse link
G Lcn2 lipocalin 2 multiple interactions EXP Amlodipine inhibits the reaction [Iohexol results in increased expression of LCN2 protein] CTD PMID:36207783 NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842 		JBrowse link
G Lep leptin decreases expression ISO Amlodipine results in decreased expression of LEP; Amlodipine results in decreased expression of LEP protein CTD PMID:18199500 PMID:19059660 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661 		JBrowse link
G Mfn2 mitofusin 2 increases expression EXP Amlodipine results in increased expression of MFN2 mRNA; Amlodipine results in increased expression of MFN2 protein CTD PMID:25464244 NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495 		JBrowse link
G Mt1a metallothionein 1A multiple interactions EXP Amlodipine inhibits the reaction [Aldosterone results in increased expression of MT1A mRNA] CTD PMID:19333130 NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr  X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200 		JBrowse link
G Mtf1 metal-regulatory transcription factor 1 multiple interactions EXP Amlodipine inhibits the reaction [Aldosterone results in increased expression of MTF1 mRNA]; Amlodipine inhibits the reaction [Aldosterone results in increased expression of MTF1 protein] CTD PMID:19333130 NCBI chr 5:142,347,024...142,391,810
Ensembl chr 5:142,347,054...142,391,810 		JBrowse link
G Myh7 myosin heavy chain 7 decreases expression EXP Amlodipine results in decreased expression of MYH7 mRNA CTD PMID:9449387 NCBI chr15:32,416,525...32,439,851
Ensembl chr15:32,416,527...32,438,194 		JBrowse link
G Nos3 nitric oxide synthase 3 increases expression EXP Amlodipine results in increased expression of NOS3 mRNA; Amlodipine results in increased expression of NOS3 protein CTD PMID:10445667 PMID:16392774 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP Amlodipine promotes the reaction [candesartan results in decreased expression of NOX1] CTD PMID:21107329 NCBI chr  X:101,572,338...101,625,571
Ensembl chr  X:101,572,340...101,595,520 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions
decreases expression 		EXP Amlodipine promotes the reaction [candesartan results in decreased expression of NOX4]
Amlodipine results in decreased expression of NOX4 mRNA 		CTD PMID:16392774 PMID:21107329 NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483 		JBrowse link
G Nppa natriuretic peptide A decreases expression EXP Amlodipine results in decreased expression of NPPA mRNA CTD PMID:17563544 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493 		JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 multiple interactions ISO Amlodipine inhibits the reaction [AGT results in increased expression of OLR1 mRNA]; Amlodipine inhibits the reaction [AGT results in increased expression of OLR1 protein] CTD PMID:21376258 NCBI chr 4:164,612,460...164,635,082
Ensembl chr 4:164,612,463...164,634,598 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO Amlodipine binds to and results in increased activity of PGR protein CTD PMID:25752796 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271 		JBrowse link
G Ppbp pro-platelet basic protein decreases expression ISO Amlodipine results in decreased expression of PPBP protein CTD PMID:15513305 NCBI chr14:17,586,495...17,587,299
Ensembl chr14:17,586,495...17,587,299 		JBrowse link
G Ppif peptidylprolyl isomerase F multiple interactions ISO
EXP 		Amlodipine inhibits the reaction [Iohexol results in increased expression of PPIF protein] CTD PMID:36207783 NCBI chr16:1,264,001...1,270,722
Ensembl chr16:1,263,541...1,316,954 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO Amlodipine results in decreased phosphorylation of RB1 protein CTD PMID:17217918 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857 		JBrowse link
G Ren renin multiple interactions ISO [Indomethacin co-treated with Amlodipine] results in decreased expression of REN protein CTD PMID:11078175 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543 		JBrowse link
G Retn resistin decreases expression ISO Amlodipine results in decreased expression of RETN protein CTD PMID:18199500 NCBI chr12:6,508,653...6,511,115
Ensembl chr12:6,508,801...6,511,116 		JBrowse link
G Selp selectin P decreases expression ISO Amlodipine results in decreased expression of SELP protein CTD PMID:15513305 NCBI chr13:79,009,379...79,044,994
Ensembl chr13:79,009,475...79,044,987 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO Amlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased phosphorylation of SMAD2 protein] CTD PMID:21337027 NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388 		JBrowse link
G Smad4 SMAD family member 4 multiple interactions ISO Amlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased expression of SMAD4 mRNA]; Amlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased expression of SMAD4 protein] CTD PMID:21337027 NCBI chr18:69,518,988...69,549,684
Ensembl chr18:69,518,988...69,549,684 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP Amlodipine inhibits the reaction [Aldosterone results in increased activity of SOD1 protein] CTD PMID:19333130 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions
decreases response to substance 		ISO
EXP 		Amlodipine results in increased expression of TGFB1 protein
Amlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased expression of SMAD4 mRNA]; Amlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased expression of SMAD4 protein]; Amlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased phosphorylation of SMAD2 protein]; Amlodipine results in decreased susceptibility to [TGFB1 protein co-treated with Doxorubicin]
Amlodipine results in decreased susceptibility to TGFB1 protein
Amlodipine inhibits the reaction [Acetaminophen results in increased expression of TGFB1 mRNA] 		CTD PMID:12937228 PMID:21337027 PMID:29441826 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Amlodipine binds to and results in increased activity of THRB protein CTD PMID:25752796 NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression 		EXP [benazepril co-treated with Amlodipine] results in decreased expression of TNF protein; Amlodipine inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]
Amlodipine results in decreased expression of TNF protein 		CTD PMID:16775501 PMID:29441826 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression EXP Amlodipine results in decreased expression of VCAM1 mRNA CTD PMID:16392774 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20849
    role 20820
      application 20622
        fuel 11502
          methanol 4011
            methyl ester 3961
              amlodipine 69
                (R)-amlodipine 0
                (S)-amlodipine 0
                amlodipine benzenesulfonate + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20849
    subatomic particle 20847
      composite particle 20860
        hadron 20847
          baryon 20860
            nucleon 20847
              atomic nucleus 20847
                atom 20860
                  main group element atom 20781
                    p-block element atom 20768
                      chalcogen 20492
                        oxygen atom 20458
                          oxygen molecular entity 20446
                            hydroxides 20231
                              organic hydroxy compound 19755
                                alcohol 16138
                                  primary alcohol 15244
                                    ethanols 10016
                                      ethanol 10016
                                        ethyl ester 6129
                                          amlodipine 69
                                            (R)-amlodipine 0
                                            (S)-amlodipine 0
                                            amlodipine benzenesulfonate + 0
paths to the root