CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: amlodipine
Accession: CHEBI:2668
browse the term
Definition: A fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.
Synonyms: exact_synonym: 3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
related_synonym: 3-Ethyl-5-methyl (+-)-2-(2-aminoethoxymethyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate; Amlodipine Free Base; Formula=C20H25ClN2O5; InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3; InChIKey=HTIQEAQVCYTUBX-UHFFFAOYSA-N; SMILES=CCOC(=O)C1=C(COCCN)NC(C)=C(C1c1ccccc1Cl)C(=O)OC; amlodipino; amlodipinum
xref: Beilstein:3570229; CAS:88150-42-9; DrugBank:DB00381; Drug_Central:183; KEGG:C06825; KEGG:D07450; LINCS:LSM-1388
xref_mesh: MESH:D017311
xref: PMID:1532771; PMID:16422032; PMID:1834846; PMID:19450066; PMID:21591999; PMID:7522286; PMID:8310972; PMID:8310973; PMID:9156957; Patent:EP89167; Patent:US4572909; Reaxys:3570229; VSDB:2963; Wikipedia:Amlodipine
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Ace
angiotensin I converting enzyme
decreases expression
EXP
Amlodipine results in decreased expression of ACE mRNA
CTD
PMID:16392774
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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Adipoq
adiponectin, C1Q and collagen domain containing
increases expression
ISO
Amlodipine results in increased expression of ADIPOQ; Amlodipine results in increased expression of ADIPOQ protein
CTD
PMID:18199500 PMID:19059660
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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Agt
angiotensinogen
multiple interactions
ISO
Amlodipine inhibits the reaction [AGT results in decreased expression of BCL2 mRNA]; Amlodipine inhibits the reaction [AGT results in decreased expression of BCL2 protein]; Amlodipine inhibits the reaction [AGT results in increased expression of BAX mRNA]; Amlodipine inhibits the reaction [AGT results in increased expression of BAX protein]; Amlodipine inhibits the reaction [AGT results in increased expression of OLR1 mRNA]; Amlodipine inhibits the reaction [AGT results in increased expression of OLR1 protein]
CTD
PMID:21376258
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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Agtr1a
angiotensin II receptor, type 1a
decreases expression
EXP
Amlodipine results in decreased expression of AGTR1A mRNA
CTD
PMID:18403896
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
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Agtr2
angiotensin II receptor, type 2
decreases expression
EXP
Amlodipine results in decreased expression of AGTR2 mRNA
CTD
PMID:18403896
NCBI chr X:112,119,673...112,124,060
Ensembl chr X:112,120,228...112,124,057
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO EXP
Amlodipine inhibits the reaction [AGT results in increased expression of BAX mRNA]; Amlodipine inhibits the reaction [AGT results in increased expression of BAX protein] Amlodipine inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; Amlodipine inhibits the reaction [Gentamicins results in increased expression of BAX protein]
CTD
PMID:17234320 PMID:19698708 PMID:21376258
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO EXP
Amlodipine inhibits the reaction [AGT results in decreased expression of BCL2 mRNA]; Amlodipine inhibits the reaction [AGT results in decreased expression of BCL2 protein] Amlodipine inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Amlodipine inhibits the reaction [Gentamicins results in decreased expression of BCL2 protein]
CTD
PMID:17234320 PMID:19698708 PMID:21376258
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bdkrb2
bradykinin receptor B2
increases response to substance
ISO
BDKRB2 results in increased susceptibility to Amlodipine
CTD
PMID:10523327
NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
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Casp3
caspase 3
multiple interactions decreases cleavage
ISO EXP
[Amlodipine co-treated with Topotecan] results in increased activity of CASP3 protein Amlodipine results in decreased cleavage of CASP3 protein
CTD
PMID:16516327 PMID:17563544
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp7
caspase 7
multiple interactions
ISO
[Amlodipine co-treated with Topotecan] results in increased activity of CASP7 protein
CTD
PMID:16516327
NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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Casp8
caspase 8
multiple interactions
ISO
[Amlodipine co-treated with Topotecan] results in increased activity of CASP8 protein
CTD
PMID:16516327
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Ccl2
C-C motif chemokine ligand 2
decreases expression
EXP
Amlodipine results in decreased expression of CCL2 mRNA
CTD
PMID:16392774
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccnd1
cyclin D1
multiple interactions
ISO
Amlodipine results in decreased activity of and results in decreased expression of CCND1 protein
CTD
PMID:17217918
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Ccne1
cyclin E1
decreases activity
ISO
Amlodipine results in decreased activity of CCNE1 protein
CTD
PMID:17217918
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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Cdk2
cyclin dependent kinase 2
decreases activity
ISO
Amlodipine results in decreased activity of CDK2 protein
CTD
PMID:17217918
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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Cdk4
cyclin-dependent kinase 4
multiple interactions
ISO
Amlodipine results in decreased activity of and results in decreased expression of CDK4 protein
CTD
PMID:17217918
NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
Amlodipine results in increased expression of CDKN1A protein
CTD
PMID:17217918 PMID:18298949
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Col1a1
collagen type I alpha 1 chain
decreases expression
EXP
Amlodipine results in decreased expression of COL1A1 mRNA
CTD
PMID:9449387
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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Col1a2
collagen type I alpha 2 chain
multiple interactions
EXP
Amlodipine inhibits the reaction [Nitric Oxide deficiency results in increased expression of COL1A2 mRNA]
CTD
PMID:10445667
NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
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Crp
C-reactive protein
multiple interactions
ISO
[Atorvastatin co-treated with Amlodipine] results in decreased expression of CRP protein
CTD
PMID:18389332
NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
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Ctsd
cathepsin D
multiple interactions
EXP
[Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]; [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]
CTD
PMID:11829124 PMID:14499179
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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Cyba
cytochrome b-245 alpha chain
multiple interactions
EXP
Amlodipine promotes the reaction [candesartan results in decreased expression of CYBA]
CTD
PMID:21107329
NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
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Cybb
cytochrome b-245 beta chain
multiple interactions
EXP
Amlodipine promotes the reaction [candesartan results in decreased expression of CYBB]
CTD
PMID:21107329
NCBI chr X:13,360,583...13,392,517
Ensembl chr X:13,359,430...13,392,586
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Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
decreases expression
EXP
Amlodipine results in decreased expression of CYP11A1 mRNA
CTD
PMID:11086231
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
decreases activity
ISO
Amlodipine results in decreased activity of CYP19A1 protein
CTD
PMID:26141389
NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases activity
ISO
Amlodipine results in decreased activity of CYP1A1 protein
CTD
PMID:10805063 PMID:33814510
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases activity
ISO
Amlodipine results in decreased activity of CYP1B1 protein
CTD
PMID:33814510
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
decreases activity
ISO
Amlodipine results in decreased activity of CYP2B6 protein
CTD
PMID:10805063
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2j4
cytochrome P450, family 2, subfamily j, polypeptide 4
decreases activity
ISO
Amlodipine results in decreased activity of CYP2J2 protein
CTD
PMID:30965050
NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
affects response to substance
ISO
CYP3A5 gene affects the susceptibility to Amlodipine
CTD
PMID:22149319
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Drd1
dopamine receptor D1
multiple interactions
ISO
Amlodipine inhibits the reaction [SCH 23390 binds to DRD1 protein]
CTD
PMID:9533112
NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
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Drd2
dopamine receptor D2
multiple interactions
ISO
Amlodipine inhibits the reaction [Raclopride binds to DRD2 protein]
CTD
PMID:9533112
NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
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Edn1
endothelin 1
affects expression
ISO
Amlodipine affects the expression of EDN1 protein
CTD
PMID:11369837
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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Gal
galanin and GMAP prepropeptide
multiple interactions
EXP
[Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of GAL protein]; [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of GAL protein]
CTD
PMID:11829124 PMID:14499179
NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959
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Gpt
glutamic--pyruvic transaminase
multiple interactions
EXP
Amlodipine inhibits the reaction [Acetaminophen results in increased activity of GPT protein]
CTD
PMID:29441826
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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Gsr
glutathione-disulfide reductase
decreases activity
EXP
Amlodipine results in decreased activity of GSR protein
CTD
PMID:17710547
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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Gusb
glucuronidase, beta
multiple interactions
EXP
[Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]
CTD
PMID:11829124 PMID:14499179
NCBI chr12:26,701,191...26,714,718
Ensembl chr12:26,697,951...26,726,905
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Hspd1
heat shock protein family D (Hsp60) member 1
multiple interactions
EXP
Amlodipine inhibits the reaction [Fructose results in increased expression of HSPD1 protein]
CTD
PMID:18948349
NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
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Icam1
intercellular adhesion molecule 1
multiple interactions decreases expression
EXP
Amlodipine inhibits the reaction [Diclofenac results in decreased expression of ICAM1 protein] Amlodipine results in decreased expression of ICAM1 protein
CTD
PMID:18460984
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Ins2
insulin 2
decreases expression
ISO
Amlodipine results in decreased expression of INS protein
CTD
PMID:19651449
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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Jak2
Janus kinase 2
increases expression
ISO
Amlodipine results in increased expression of JAK2 protein modified form
CTD
PMID:18298949
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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Lep
leptin
decreases expression
ISO
Amlodipine results in decreased expression of LEP; Amlodipine results in decreased expression of LEP protein
CTD
PMID:18199500 PMID:19059660
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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Mfn2
mitofusin 2
increases expression
EXP
Amlodipine results in increased expression of MFN2 mRNA; Amlodipine results in increased expression of MFN2 protein
CTD
PMID:25464244
NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
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Mt1
metallothionein 1
multiple interactions
EXP
Amlodipine inhibits the reaction [Aldosterone results in increased expression of MT1A mRNA]
CTD
PMID:19333130
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
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Mtf1
metal-regulatory transcription factor 1
multiple interactions
EXP
Amlodipine inhibits the reaction [Aldosterone results in increased expression of MTF1 mRNA]; Amlodipine inhibits the reaction [Aldosterone results in increased expression of MTF1 protein]
CTD
PMID:19333130
NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136
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Myh7
myosin heavy chain 7
decreases expression
EXP
Amlodipine results in decreased expression of MYH7 mRNA
CTD
PMID:9449387
NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
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Nos3
nitric oxide synthase 3
increases expression
EXP
Amlodipine results in increased expression of NOS3 mRNA; Amlodipine results in increased expression of NOS3 protein
CTD
PMID:10445667 PMID:16392774
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Nox1
NADPH oxidase 1
multiple interactions
EXP
Amlodipine promotes the reaction [candesartan results in decreased expression of NOX1]
CTD
PMID:21107329
NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236
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Nox4
NADPH oxidase 4
multiple interactions decreases expression
EXP
Amlodipine promotes the reaction [candesartan results in decreased expression of NOX4] Amlodipine results in decreased expression of NOX4 mRNA
CTD
PMID:16392774 PMID:21107329
NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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Nppa
natriuretic peptide A
decreases expression
EXP
Amlodipine results in decreased expression of NPPA mRNA
CTD
PMID:17563544
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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Olr1
oxidized low density lipoprotein receptor 1
multiple interactions
ISO
Amlodipine inhibits the reaction [AGT results in increased expression of OLR1 mRNA]; Amlodipine inhibits the reaction [AGT results in increased expression of OLR1 protein]
CTD
PMID:21376258
NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
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Pgr
progesterone receptor
multiple interactions
ISO
Amlodipine binds to and results in increased activity of PGR protein
CTD
PMID:25752796
NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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Ppbp
pro-platelet basic protein
decreases expression
ISO
Amlodipine results in decreased expression of PPBP protein
CTD
PMID:15513305
NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130
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Rb1
RB transcriptional corepressor 1
decreases phosphorylation
ISO
Amlodipine results in decreased phosphorylation of RB1 protein
CTD
PMID:17217918
NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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Ren
renin
multiple interactions
ISO
[Indomethacin co-treated with Amlodipine] results in decreased expression of REN protein
CTD
PMID:11078175
NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
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Retn
resistin
decreases expression
ISO
Amlodipine results in decreased expression of RETN protein
CTD
PMID:18199500
NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620
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Selp
selectin P
decreases expression
ISO
Amlodipine results in decreased expression of SELP protein
CTD
PMID:15513305
NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
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Smad2
SMAD family member 2
multiple interactions
ISO
Amlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased phosphorylation of SMAD2 protein]
CTD
PMID:21337027
NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
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Smad4
SMAD family member 4
multiple interactions
ISO
Amlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased expression of SMAD4 mRNA]; Amlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased expression of SMAD4 protein]
CTD
PMID:21337027
NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
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Sod1
superoxide dismutase 1
multiple interactions
EXP
Amlodipine inhibits the reaction [Aldosterone results in increased activity of SOD1 protein]
CTD
PMID:19333130
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Tgfb1
transforming growth factor, beta 1
increases expression multiple interactions decreases response to substance
ISO EXP
Amlodipine results in increased expression of TGFB1 protein Amlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased expression of SMAD4 mRNA]; Amlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased expression of SMAD4 protein]; Amlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased phosphorylation of SMAD2 protein]; Amlodipine results in decreased susceptibility to [TGFB1 protein co-treated with Doxorubicin] Amlodipine results in decreased susceptibility to TGFB1 protein Amlodipine inhibits the reaction [Acetaminophen results in increased expression of TGFB1 mRNA]
CTD
PMID:12937228 PMID:21337027 PMID:29441826
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Thrb
thyroid hormone receptor beta
multiple interactions
ISO
Amlodipine binds to and results in increased activity of THRB protein
CTD
PMID:25752796
NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
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Tnf
tumor necrosis factor
multiple interactions decreases expression
EXP
[benazepril co-treated with Amlodipine] results in decreased expression of TNF protein; Amlodipine inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA] Amlodipine results in decreased expression of TNF protein
CTD
PMID:16775501 PMID:29441826
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Vcam1
vascular cell adhesion molecule 1
decreases expression
EXP
Amlodipine results in decreased expression of VCAM1 mRNA
CTD
PMID:16392774
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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