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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:amitraz
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Accession:CHEBI:2665 term browser browse the term
Definition:A tertiary amino compound that is 1,3,5-triazapenta-1,4-diene substituted by a methyl group at position 3 and 2,4-dimethylphenyl groups at positions 1 and 5.
Synonyms:exact_synonym: N'-(2,4-dimethylphenyl)-N-{[(2,4-dimethylphenyl)imino]methyl}-N-methylmethanimidamide
 related_synonym: 1,5-di(2,4-dimethylphenyl)-3-methyl-1,3,5-triazapenta-1,4-diene;   Formula=C19H23N3;   InChI=1S/C19H23N3/c1-14-6-8-18(16(3)10-14)20-12-22(5)13-21-19-9-7-15(2)11-17(19)4/h6-13H,1-5H3;   InChIKey=QXAITBQSYVNQDR-UHFFFAOYSA-N;   Mitac;   N,N'-(methyliminodimethylidyne)bis-2,4-xylidine;   SMILES=CN(C=Nc1ccc(C)cc1C)C=Nc1ccc(C)cc1C
 xref: Beilstein:2946590;   CAS:33089-61-1;   KEGG:C10995;   KEGG:D02380
 xref_mesh: MESH:C014983
 xref: PMID:10885999;   PMID:15822764;   PMID:24288053;   PMID:25053051;   PPDB:30;   Pesticides:amitraz;   Reaxys:2946590;   VSDB:30;   Wikipedia:Amitraz


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amitraz term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A multiple interactions
decreases activity
EXP
ISO
[Idazoxan binds to and results in decreased activity of ADRA2A protein] which results in decreased susceptibility to amitraz; amitraz binds to and results in increased activity of ADRA2A protein
amitraz results in decreased activity of ADRA2A protein
CTD PMID:10582558 PMID:21251949 NCBI chr 1:253,061,480...253,064,280 JBrowse link
G Cat catalase decreases expression
multiple interactions
EXP amitraz results in decreased expression of CAT protein
KEAP1 protein affects the reaction [amitraz results in decreased expression of CAT protein]
CTD PMID:31029719 NCBI chr 3:89,842,393...89,874,577 JBrowse link
G Comt catechol-O-methyltransferase multiple interactions
affects expression
EXP Tamoxifen inhibits the reaction [amitraz affects the expression of COMT mRNA]; Tamoxifen inhibits the reaction [amitraz affects the expression of COMT protein]
amitraz affects the expression of COMT mRNA; amitraz affects the expression of COMT protein
CTD PMID:28463726 NCBI chr11:82,568,052...82,587,642 JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression EXP amitraz results in increased expression of CYP19A1 mRNA; amitraz results in increased expression of CYP19A1 protein CTD PMID:28463726 NCBI chr 8:54,553,165...54,580,758 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP amitraz results in increased expression of CYP1A1 protein CTD PMID:15350676 PMID:31029719 NCBI chr 8:58,096,021...58,102,130 JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP amitraz results in increased expression of CYP1A2 protein CTD PMID:15350676 PMID:31029719 NCBI chr 8:58,075,367...58,082,255 JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP amitraz results in increased expression of CYP2B1 protein CTD PMID:15350676 PMID:31029719 NCBI chr 1:81,518,387...81,544,999 JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP amitraz results in increased expression of CYP2B2 protein CTD PMID:15350676 PMID:31029719 NCBI chr 1:81,594,534...81,608,567 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression EXP amitraz results in increased expression of CYP2E1 protein CTD PMID:31029719 NCBI chr 1:195,840,330...195,850,728 JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP amitraz results in increased expression of CYP3A23-3A1 protein CTD PMID:31029719 NCBI chr12:9,256,159...9,285,020 JBrowse link
G Dbh dopamine beta-hydroxylase multiple interactions
increases expression
EXP Tamoxifen inhibits the reaction [amitraz results in increased expression of DBH mRNA]; Tamoxifen inhibits the reaction [amitraz results in increased expression of DBH protein]
amitraz results in increased expression of DBH mRNA; amitraz results in increased expression of DBH protein
CTD PMID:28463726 NCBI chr 3:10,488,260...10,505,245 JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO amitraz inhibits the reaction [Spiperone binds to DRD2 protein] CTD PMID:2833825 NCBI chr 8:49,708,903...49,772,888 JBrowse link
G Gad2 glutamate decarboxylase 2 affects expression
multiple interactions
EXP amitraz affects the expression of GAD2 mRNA
[methylhistaprodifen co-treated with Idazoxan] inhibits the reaction [amitraz affects the expression of GAD2 mRNA]; Idazoxan inhibits the reaction [amitraz affects the expression of GAD2 mRNA]; methylhistaprodifen inhibits the reaction [amitraz affects the expression of GAD2 mRNA]
CTD PMID:26141220 NCBI chr17:84,763,630...84,826,155 JBrowse link
G Gcg glucagon increases secretion EXP amitraz results in increased secretion of GCG protein CTD PMID:10582558 NCBI chr 3:47,113,914...47,122,929 JBrowse link
G Gls glutaminase multiple interactions
increases expression
EXP [methylhistaprodifen co-treated with Idazoxan] inhibits the reaction [amitraz results in increased expression of GLS mRNA]; methylhistaprodifen inhibits the reaction [amitraz results in increased expression of GLS mRNA] CTD PMID:26141220 NCBI chr 9:49,344,616...49,416,900 JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression
multiple interactions
EXP amitraz results in increased expression of KEAP1 protein
KEAP1 protein affects the reaction [amitraz results in decreased expression of CAT protein]; KEAP1 protein affects the reaction [amitraz results in decreased expression of NFE2L2 protein]; KEAP1 protein affects the reaction [amitraz results in decreased expression of NQO1 protein]; KEAP1 protein affects the reaction [amitraz results in decreased expression of SOD1 protein]
CTD PMID:31029719 NCBI chr 8:19,768,375...19,777,862 JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP amitraz results in increased expression of LHB protein CTD PMID:16085667 NCBI chr 1:95,898,269...95,901,973 JBrowse link
G Maoa monoamine oxidase A multiple interactions
decreases expression
EXP Tamoxifen inhibits the reaction [amitraz results in decreased expression of MAOA mRNA]; Tamoxifen inhibits the reaction [amitraz results in decreased expression of MAOA protein]
amitraz results in decreased expression of MAOA mRNA; amitraz results in decreased expression of MAOA protein
CTD PMID:28463726 NCBI chr  X:6,032,172...6,098,308 JBrowse link
G Maob monoamine oxidase B decreases expression
multiple interactions
EXP amitraz results in decreased expression of MAOB mRNA; amitraz results in decreased expression of MAOB protein
Tamoxifen inhibits the reaction [amitraz results in decreased expression of MAOB mRNA]; Tamoxifen inhibits the reaction [amitraz results in decreased expression of MAOB protein]
CTD PMID:28463726 NCBI chr  X:5,907,327...6,010,996 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases expression
multiple interactions
EXP amitraz results in decreased expression of NFE2L2 protein
KEAP1 protein affects the reaction [amitraz results in decreased expression of NFE2L2 protein]
CTD PMID:31029719 NCBI chr 3:60,594,239...60,621,785 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression
multiple interactions
EXP amitraz results in decreased expression of NQO1 protein
KEAP1 protein affects the reaction [amitraz results in decreased expression of NQO1 protein]
CTD PMID:31029719 NCBI chr19:35,295,633...35,310,528 JBrowse link
G Por cytochrome p450 oxidoreductase increases activity EXP amitraz results in increased activity of POR protein CTD PMID:15350676 NCBI chr12:20,951,058...20,999,198 JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO amitraz inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268 JBrowse link
G Sod1 superoxide dismutase 1 decreases expression
multiple interactions
EXP amitraz results in decreased expression of SOD1 protein
KEAP1 protein affects the reaction [amitraz results in decreased expression of SOD1 protein]
CTD PMID:31029719 NCBI chr11:29,456,673...29,462,249 JBrowse link
G Th tyrosine hydroxylase multiple interactions
increases expression
EXP Tamoxifen inhibits the reaction [amitraz results in increased expression of TH mRNA]; Tamoxifen inhibits the reaction [amitraz results in increased expression of TH protein]
amitraz results in increased expression of TH mRNA; amitraz results in increased expression of TH protein
CTD PMID:28463726 NCBI chr 1:198,071,500...198,078,832 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19762
    role 19708
      biological role 19708
        xenobiotic 18395
          amitraz 25
Path 2
Term Annotations click to browse term
  CHEBI ontology 19762
    subatomic particle 19760
      composite particle 19760
        hadron 19760
          baryon 19760
            nucleon 19760
              atomic nucleus 19760
                atom 19760
                  main group element atom 19651
                    main group molecular entity 19651
                      s-block molecular entity 19418
                        hydrogen molecular entity 19413
                          hydrides 18746
                            inorganic hydride 17471
                              pnictogen hydride 17448
                                nitrogen hydride 17302
                                  azane 17009
                                    ammonia 17008
                                      organic amino compound 17007
                                        tertiary amino compound 8668
                                          amitraz 25
paths to the root