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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:semiochemical
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Accession:CHEBI:26645 term browser browse the term
Definition:A molecular messenger released by an organism that affects the behaviour within or between species.
Synonyms:related_synonym: semiochemicals
 xref: Wikipedia:Semiochemical


show annotations for term's descendants           Sort by:
(+)-pinoresinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACACA acetyl-CoA carboxylase alpha decreases expression
multiple interactions		 EXP pinoresinol results in decreased expression of ACACA protein
[loliolide co-treated with pinoresinol] results in decreased expression of ACACA protein		 CTD PMID:31610126 NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836 		JBrowse link
G FASN fatty acid synthase decreases expression
multiple interactions		 EXP pinoresinol results in decreased expression of FASN protein
[loliolide co-treated with pinoresinol] results in decreased expression of FASN protein		 CTD PMID:31610126 NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294 		JBrowse link
G NR1H2 nuclear receptor subfamily 1 group H member 2 multiple interactions EXP pinoresinol results in increased ubiquitination of and results in increased degradation of and results in decreased expression of NR1H2 protein CTD PMID:31610126 NCBI chr19:50,376,457...50,383,388
Ensembl chr19:50,329,653...50,383,388 		JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 multiple interactions EXP pinoresinol results in increased ubiquitination of and results in increased degradation of and results in decreased expression of NR1H3 protein CTD PMID:31610126 NCBI chr11:47,248,300...47,269,033
Ensembl chr11:47,248,300...47,269,033 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO pinoresinol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:21191767 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions
decreases expression		 EXP [loliolide co-treated with pinoresinol] results in decreased expression of SREBF1 protein
pinoresinol results in decreased expression of SREBF1 protein		 CTD PMID:31610126 NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002 		JBrowse link
G TNF tumor necrosis factor decreases secretion EXP pinoresinol results in decreased secretion of TNF protein CTD PMID:29740324 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNA1 cyclin A1 decreases expression EXP fluorotelomer alcohols results in decreased expression of CCNA1 mRNA CTD PMID:30794351 NCBI chr13:36,431,517...36,442,870
Ensembl chr13:36,431,520...36,442,870 		JBrowse link
G CCNA2 cyclin A2 decreases expression EXP fluorotelomer alcohols results in decreased expression of CCNA2 mRNA CTD PMID:30794351 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883 		JBrowse link
G CCND1 cyclin D1 decreases expression EXP fluorotelomer alcohols results in decreased expression of CCND1 mRNA CTD PMID:30794351 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CCNE2 cyclin E2 decreases expression EXP fluorotelomer alcohols results in decreased expression of CCNE2 mRNA CTD PMID:30794351 NCBI chr 8:94,880,224...94,896,693
Ensembl chr 8:94,879,770...94,896,678 		JBrowse link
G CEBPE CCAAT enhancer binding protein epsilon decreases expression EXP fluorotelomer alcohols results in decreased expression of CEBPE mRNA CTD PMID:30794351 NCBI chr14:23,117,306...23,119,255
Ensembl chr14:23,117,036...23,120,256 		JBrowse link
G CSF3R colony stimulating factor 3 receptor decreases expression EXP fluorotelomer alcohols results in decreased expression of CSF3R mRNA CTD PMID:30794351 NCBI chr 1:36,466,043...36,483,314
Ensembl chr 1:36,466,043...36,483,278 		JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 decreases expression ISO fluorotelomer alcohols results in decreased expression of CXCL1 mRNA CTD PMID:30536526 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308 		JBrowse link
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 decreases expression EXP fluorotelomer alcohols results in decreased expression of CYP11A1 mRNA; fluorotelomer alcohols results in decreased expression of CYP11A1 protein CTD PMID:20615422 NCBI chr15:74,337,762...74,367,646
Ensembl chr15:74,337,759...74,367,646 		JBrowse link
G CYP11B1 cytochrome P450 family 11 subfamily B member 1 decreases expression EXP fluorotelomer alcohols results in decreased expression of CYP11B1 mRNA; fluorotelomer alcohols results in decreased expression of CYP11B1 protein CTD PMID:20615422 NCBI chr 8:142,872,357...142,879,825
Ensembl chr 8:142,872,356...142,879,846 		JBrowse link
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 decreases expression EXP fluorotelomer alcohols results in decreased expression of CYP11B2 mRNA; fluorotelomer alcohols results in decreased expression of CYP11B2 protein CTD PMID:20615422 NCBI chr 8:142,910,559...142,917,843
Ensembl chr 8:142,910,559...142,917,843 		JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 decreases expression EXP fluorotelomer alcohols results in decreased expression of CYP17A1 mRNA; fluorotelomer alcohols results in decreased expression of CYP17A1 protein CTD PMID:20615422 NCBI chr10:102,830,531...102,837,413
Ensembl chr10:102,830,531...102,837,472 		JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 increases expression EXP fluorotelomer alcohols results in increased expression of CYP19A1 mRNA CTD PMID:23142464 NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases activity EXP fluorotelomer alcohols results in decreased activity of CYP2E1 protein CTD PMID:35121066 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 decreases expression EXP fluorotelomer alcohols results in decreased expression of ERBB2 mRNA CTD PMID:16393665 NCBI chr17:39,688,094...39,728,658
Ensembl chr17:39,687,914...39,730,426 		JBrowse link
G ESR1 estrogen receptor 1 increases activity
multiple interactions
increases expression		 EXP fluorotelomer alcohols results in increased activity of ESR1 protein
fluorotelomer alcohols promotes the reaction [ESR1 protein binds to NCOA2 protein]
fluorotelomer alcohols results in increased expression of ESR1 mRNA		 CTD PMID:16393665 PMID:17603182 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G ESR2 estrogen receptor 2 multiple interactions
increases activity		 EXP fluorotelomer alcohols promotes the reaction [ESR2 protein binds to NCOA2 protein]
fluorotelomer alcohols results in increased activity of ESR2 protein		 CTD PMID:17603182 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
G IFNG interferon gamma multiple interactions ISO fluorotelomer alcohols inhibits the reaction [Mitogens results in increased secretion of IFNG protein] CTD PMID:30536526 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL1B interleukin 1 beta affects expression
multiple interactions		 ISO fluorotelomer alcohols affects the expression of IL1B mRNA
fluorotelomer alcohols results in decreased expression of and results in decreased secretion of IL1B protein		 CTD PMID:30536526 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 decreases expression ISO fluorotelomer alcohols results in decreased expression of IL6 mRNA CTD PMID:30536526 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G ITGAM integrin subunit alpha M decreases expression EXP fluorotelomer alcohols results in decreased expression of ITGAM mRNA CTD PMID:30794351 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892 		JBrowse link
G NCOA2 nuclear receptor coactivator 2 multiple interactions EXP fluorotelomer alcohols promotes the reaction [ESR1 protein binds to NCOA2 protein]; fluorotelomer alcohols promotes the reaction [ESR2 protein binds to NCOA2 protein] CTD PMID:17603182 NCBI chr 8:70,109,782...70,456,446
Ensembl chr 8:70,109,782...70,403,808 		JBrowse link
G PDZK1 PDZ domain containing 1 increases expression EXP fluorotelomer alcohols results in increased expression of PDZK1 mRNA CTD PMID:16393665 NCBI chr 1:145,670,852...145,707,400
Ensembl chr 1:145,670,852...145,708,148 		JBrowse link
G PGR progesterone receptor increases expression EXP fluorotelomer alcohols results in increased expression of PGR mRNA CTD PMID:16393665 NCBI chr11:101,029,624...101,129,813
Ensembl chr11:101,029,624...101,129,813 		JBrowse link
G SLC22A7 solute carrier family 22 member 7 increases expression ISO fluorotelomer alcohols results in increased expression of SLC22A7 mRNA CTD PMID:21530637 NCBI chr 6:43,295,714...43,305,538
Ensembl chr 6:43,295,694...43,305,538 		JBrowse link
G SPI1 Spi-1 proto-oncogene decreases expression EXP fluorotelomer alcohols results in decreased expression of SPI1 mRNA CTD PMID:30794351 NCBI chr11:47,354,860...47,378,547
Ensembl chr11:47,354,860...47,409,369 		JBrowse link
G STAR steroidogenic acute regulatory protein decreases expression EXP fluorotelomer alcohols results in decreased expression of STAR mRNA; fluorotelomer alcohols results in decreased expression of STAR protein CTD PMID:20615422 NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992 		JBrowse link
G TFF1 trefoil factor 1 increases expression EXP fluorotelomer alcohols results in increased expression of TFF1 mRNA CTD PMID:16393665 NCBI chr21:42,362,282...42,366,535
Ensembl chr21:42,362,282...42,366,535 		JBrowse link
G TNF tumor necrosis factor decreases expression ISO fluorotelomer alcohols results in decreased expression of TNF mRNA CTD PMID:30536526 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TSPO translocator protein decreases expression EXP fluorotelomer alcohols results in decreased expression of TSPO mRNA CTD PMID:23142464 NCBI chr22:43,151,559...43,163,242
Ensembl chr22:43,151,547...43,163,242 		JBrowse link
5alpha-androst-16-en-3alpha-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 multiple interactions ISO [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [androst-16-en-3-ol results in decreased activity of NR1I3 protein]] which results in increased expression of CYP2B6 mRNA; [Endosulfan inhibits the reaction [androst-16-en-3-ol results in decreased activity of NR1I3 protein]] which results in increased expression of CYP2B6 mRNA CTD PMID:20361990 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398 		JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 decreases activity
multiple interactions		 ISO androst-16-en-3-ol results in decreased activity of NR1I3 protein
1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [androst-16-en-3-ol results in decreased activity of NR1I3 protein]; [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [androst-16-en-3-ol results in decreased activity of NR1I3 protein]] which results in increased expression of CYP2B6 mRNA; [Endosulfan inhibits the reaction [androst-16-en-3-ol results in decreased activity of NR1I3 protein]] which results in increased expression of CYP2B6 mRNA		 CTD PMID:20361990 NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,244 		JBrowse link
actinidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G OCLN occludin increases cleavage EXP actinidine results in increased cleavage of OCLN protein CTD PMID:25042511 NCBI chr 5:69,492,547...69,558,104
Ensembl chr 5:69,492,292...69,558,104 		JBrowse link
androsterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AR androgen receptor affects binding ISO Androsterone binds to AR protein CTD PMID:14565775 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619 		JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 affects chemical synthesis EXP CYP17A1 protein affects the chemical synthesis of Androsterone CTD PMID:14522586 NCBI chr10:102,830,531...102,837,413
Ensembl chr10:102,830,531...102,837,472 		JBrowse link
G DHRS11 dehydrogenase/reductase 11 increases reduction EXP DHRS11 protein results in increased reduction of Androsterone CTD PMID:30926317 NCBI chr17:36,591,879...36,600,804
Ensembl chr17:36,591,879...36,600,804 		JBrowse link
G G6PD glucose-6-phosphate dehydrogenase decreases activity ISO Androsterone results in decreased activity of G6PD protein CTD PMID:7752092 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,517,825...154,547,572 		JBrowse link
G HSD17B12 hydroxysteroid 17-beta dehydrogenase 12 increases metabolic processing ISO HSD17B12 protein results in increased metabolism of Androsterone CTD PMID:17641292 NCBI chr11:43,556,721...43,856,615
Ensembl chr11:43,680,680...43,856,617 		JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Androsterone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638 		JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 multiple interactions EXP Androsterone inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Diethylstilbestrol] CTD PMID:23126256 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300 		JBrowse link
G UGT1A3 UDP glucuronosyltransferase family 1 member A3 multiple interactions EXP Androsterone inhibits the reaction [[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Androsterone inhibits the reaction [UGT1A3 protein results in increased glucuronidation of Hymecromone] CTD PMID:33290829 NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,042...233,773,300 		JBrowse link
G UGT1A4 UDP glucuronosyltransferase family 1 member A4 increases glucuronidation EXP UGT1A4 protein SNP results in increased glucuronidation of Androsterone analog CTD PMID:15708967 NCBI chr 2:233,718,736...233,773,300
Ensembl chr 2:233,718,736...233,773,300 		JBrowse link
G UGT2B15 UDP glucuronosyltransferase family 2 member B15 multiple interactions EXP Androsterone inhibits the reaction [[UGT2B15 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Androsterone inhibits the reaction [UGT2B15 protein results in increased glucuronidation of Hymecromone] CTD PMID:33290829 NCBI chr 4:68,646,597...68,670,652
Ensembl chr 4:68,646,597...68,670,652 		JBrowse link
G UGT2B17 UDP glucuronosyltransferase family 2 member B17 increases metabolic processing EXP UGT2B17 protein results in increased metabolism of Androsterone CTD PMID:8798464 NCBI chr 4:68,537,173...68,576,322
Ensembl chr 4:68,537,173...68,576,413 		JBrowse link
G UGT2B7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation
decreases activity
multiple interactions		 EXP UGT2B7 protein results in increased glucuronidation of Androsterone
Androsterone results in decreased activity of UGT2B7 protein
Androsterone inhibits the reaction [[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Androsterone inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Diethylstilbestrol]; Androsterone inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Hymecromone]		 CTD PMID:11186130 PMID:23126256 PMID:26875642 PMID:33290829 NCBI chr 4:69,051,375...69,112,987
Ensembl chr 4:69,051,363...69,112,987 		JBrowse link
androsterone 3-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KL klotho multiple interactions ISO androsterone glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] CTD PMID:14701853 NCBI chr13:33,016,243...33,066,143
Ensembl chr13:33,016,423...33,066,143 		JBrowse link
decan-1-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator increases activity EXP n-decyl alcohol results in increased activity of CFTR protein CTD PMID:14967738 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971 		JBrowse link
dodecan-1-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF3 activating transcription factor 3 increases expression EXP Dodecanol analog results in increased expression of ATF3 mRNA CTD PMID:27965148 NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression EXP Dodecanol analog results in increased expression of CXCL8 mRNA CTD PMID:27965148 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G DNAJB4 DnaJ heat shock protein family (Hsp40) member B4 increases expression EXP Dodecanol analog results in increased expression of DNAJB4 mRNA CTD PMID:27965148 NCBI chr 1:77,979,175...78,017,964
Ensembl chr 1:77,979,175...78,017,964 		JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit increases expression EXP Dodecanol analog results in increased expression of GCLM mRNA CTD PMID:27965148 NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456 		JBrowse link
geranic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TYR tyrosinase decreases expression ISO decaprenoic acid results in decreased expression of TYR protein CTD PMID:23286867 NCBI chr11:89,177,875...89,295,759
Ensembl chr11:89,177,875...89,295,759 		JBrowse link
heptan-2-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GNA15 G protein subunit alpha 15 increases response to substance
multiple interactions		 EXP GNA15 protein results in increased susceptibility to 2-heptanone
[GNA15 protein results in increased susceptibility to 2-heptanone] which results in decreased activity of OR5G26 protein		 CTD PMID:15598656 NCBI chr19:3,136,033...3,163,749
Ensembl chr19:3,136,033...3,163,749 		JBrowse link
G GNAL G protein subunit alpha L multiple interactions
increases response to substance		 EXP [GNAL protein results in increased susceptibility to 2-heptanone] which results in increased activity of OR5G26 protein CTD PMID:15598656 NCBI chr18:11,689,264...11,885,685
Ensembl chr18:11,689,264...11,885,685 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 decreases activity EXP 2-heptanone results in decreased activity of GSTP1 protein CTD PMID:18409811 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656 		JBrowse link
G OR5G3 olfactory receptor family 5 subfamily G member 3 (gene/pseudogene) multiple interactions EXP [GNA15 protein results in increased susceptibility to 2-heptanone] which results in decreased activity of OR5G26 protein; [GNAL protein results in increased susceptibility to 2-heptanone] which results in increased activity of OR5G26 protein CTD PMID:15598656 NCBI chr11:56,819,479...56,820,646
Ensembl chr11:56,819,573...56,820,516 		JBrowse link
monohexyl phthalate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSF1 heat shock transcription factor 1 increases activity EXP mono-n-hexyl phthalate results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 8:144,291,604...144,314,720
Ensembl chr 8:144,291,591...144,314,720 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha affects binding EXP mono-n-hexyl phthalate binds to PPARA protein CTD PMID:23843199 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755 		JBrowse link
G PPARD peroxisome proliferator activated receptor delta affects binding EXP mono-n-hexyl phthalate binds to PPARB protein CTD PMID:23843199 NCBI chr 6:35,342,558...35,428,178
Ensembl chr 6:35,342,558...35,428,191 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma affects binding EXP mono-n-hexyl phthalate binds to PPARG protein CTD PMID:23843199 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
monooctyl phthalate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPARA peroxisome proliferator activated receptor alpha affects binding EXP mono-n-octyl phthalate binds to PPARA protein CTD PMID:23843199 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755 		JBrowse link
G PPARD peroxisome proliferator activated receptor delta affects binding EXP mono-n-octyl phthalate binds to PPARB protein CTD PMID:23843199 NCBI chr 6:35,342,558...35,428,178
Ensembl chr 6:35,342,558...35,428,191 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma affects binding EXP mono-n-octyl phthalate binds to PPARG protein CTD PMID:23843199 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
nerolidol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen multiple interactions ISO [nerolidol co-treated with AGT protein] results in increased expression of GPX4 protein; nerolidol inhibits the reaction [AGT protein results in decreased expression of CAT protein]; nerolidol inhibits the reaction [AGT protein results in decreased expression of SOD2 protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of IL6 protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of MMP2 protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of MMP9 protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of NOS2 protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of TLR4 protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of TNF protein]; nerolidol inhibits the reaction [AGT protein results in increased phosphorylation of and affects the localization of RELA protein]; nerolidol inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; nerolidol inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein] CTD PMID:33212213 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576 		JBrowse link
G AGTR1 angiotensin II receptor type 1 multiple interactions ISO nerolidol inhibits the reaction [AGT protein results in increased expression of AGTR1A protein] CTD PMID:33212213 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO nerolidol inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased phosphorylation of AKT1 protein] CTD PMID:36169646 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression EXP nerolidol results in increased expression of BAX mRNA CTD PMID:35357761 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP nerolidol results in decreased expression of BCL2 mRNA CTD PMID:35357761 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G CASP3 caspase 3 increases expression EXP nerolidol results in increased expression of CASP3 mRNA CTD PMID:35357761 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CAT catalase multiple interactions ISO nerolidol inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased activity of CAT protein]; nerolidol inhibits the reaction [AGT protein results in decreased expression of CAT protein] CTD PMID:33212213 PMID:36169646 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CCND1 cyclin D1 decreases expression EXP nerolidol results in decreased expression of CCND1 mRNA CTD PMID:35357761 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G G6PD glucose-6-phosphate dehydrogenase multiple interactions ISO nerolidol inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased activity of G6PD protein] CTD PMID:36169646 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,517,825...154,547,572 		JBrowse link
G GCK glucokinase multiple interactions ISO nerolidol inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased activity of GCK protein] CTD PMID:36169646 NCBI chr 7:44,143,213...44,189,439
Ensembl chr 7:44,143,213...44,198,170 		JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO nerolidol inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased activity of GPT protein] CTD PMID:36169646 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174 		JBrowse link
G GPX4 glutathione peroxidase 4 multiple interactions ISO [nerolidol co-treated with AGT protein] results in increased expression of GPX4 protein CTD PMID:33212213 NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,982...1,106,791 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO nerolidol inhibits the reaction [AGT protein results in increased expression of IL6 protein] CTD PMID:33212213 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G INS-IGF2 INS-IGF2 readthrough multiple interactions ISO nerolidol inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of INS1 protein] CTD PMID:36169646 NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209 		JBrowse link
G IRS1 insulin receptor substrate 1 multiple interactions ISO nerolidol inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of IRS1 protein] CTD PMID:36169646 NCBI chr 2:226,731,312...226,799,820
Ensembl chr 2:226,731,312...226,799,820 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO nerolidol inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein] CTD PMID:33212213 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO nerolidol inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein] CTD PMID:33212213 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP nerolidol results in increased expression of and results in increased phosphorylation of MAPK8 mRNA CTD PMID:35357761 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions ISO nerolidol inhibits the reaction [AGT protein results in increased expression of MMP2 protein] CTD PMID:33212213 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions ISO nerolidol inhibits the reaction [AGT protein results in increased expression of MMP9 protein] CTD PMID:33212213 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO nerolidol inhibits the reaction [AGT protein results in increased expression of NOS2 protein] CTD PMID:33212213 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO nerolidol inhibits the reaction [AGT protein results in increased expression of PTGS2 protein] CTD PMID:33212213 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO nerolidol inhibits the reaction [AGT protein results in increased phosphorylation of and affects the localization of RELA protein] CTD PMID:33212213 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G SLC2A4 solute carrier family 2 member 4 multiple interactions ISO nerolidol inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of SLC2A4 protein] CTD PMID:36169646 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257 		JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions ISO nerolidol inhibits the reaction [AGT protein results in decreased expression of SOD2 protein] CTD PMID:33212213 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO nerolidol inhibits the reaction [AGT protein results in increased expression of TGFB1 protein] CTD PMID:33212213 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TLR4 toll like receptor 4 multiple interactions ISO nerolidol inhibits the reaction [AGT protein results in increased expression of TLR4 protein] CTD PMID:33212213 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO nerolidol inhibits the reaction [AGT protein results in increased expression of TNF protein] CTD PMID:33212213 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
octan-1-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide increases metabolic processing
multiple interactions		 EXP ADH5 protein results in increased metabolism of 1-Octanol
Pentachlorophenol inhibits the reaction [ADH5 protein results in increased metabolism of 1-Octanol]		 CTD PMID:19822198 NCBI chr 4:99,070,978...99,088,788
Ensembl chr 4:99,070,978...99,088,801 		JBrowse link
G CFTR CF transmembrane conductance regulator increases activity
multiple interactions		 EXP 1-Octanol results in increased activity of CFTR protein; 1-Octanol results in increased activity of CFTR protein mutant form
Glyburide inhibits the reaction [1-Octanol results in increased activity of CFTR protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [1-Octanol results in increased activity of CFTR protein]		 CTD PMID:14967738 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971 		JBrowse link
G TNF tumor necrosis factor increases expression EXP 1-Octanol results in increased expression of TNF protein CTD PMID:29953848 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 26439
    role 26271
      biological role 26250
        molecular messenger 20277
          semiochemical 88
            (4E,6E)-2,6-dimethylocta-2,4,6-triene 0
            7-epi-zingiberene 0
            divarinol 0
            hexan-2-ol 0
            hydroxy fatty acid ascaroside + 0
            hydroxy fatty amide ascaroside + 0
            kairomone + 6
            pentacosane + 0
            perillene 0
            pheromone + 87
paths to the root