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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:selenium molecular entity
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Accession:CHEBI:26628 term browser browse the term
Synonyms:related_synonym: selenium molecular entities


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disodium selenite term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAK1 BCL2 antagonist/killer 1 multiple interactions EXP Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAK1 protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in increased expression of BAK1 protein]; Sodium Selenite inhibits the reaction [MIR125A mRNA mutant form results in increased expression of BAK1 protein] CTD PMID:26607349 NCBI chr 7:29,808,849...29,815,345 JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
affects expression		 EXP Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAX protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]; Sodium Selenite inhibits the reaction [MIR125A mRNA mutant form results in increased expression of BAX protein]
Sodium Selenite affects the expression of BAX mRNA		 CTD PMID:17342738 PMID:26607349 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140 		JBrowse link
G BCL2L1 BCL2 like 1 affects expression EXP Sodium Selenite affects the expression of BCL2L1 mRNA CTD PMID:17342738 NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,143...35,414,694 		JBrowse link
G CASP3 caspase 3 multiple interactions
decreases expression		 EXP Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP3 protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in increased expression of CASP3 protein]; Sodium Selenite inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Sodium Selenite inhibits the reaction [MIR125A mRNA mutant form results in increased expression of CASP3 protein]
Sodium Selenite results in decreased expression of CASP3 protein		 CTD PMID:15191356 PMID:17342738 PMID:26607349 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
G CASP9 caspase 9 multiple interactions EXP Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP9 protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in increased expression of CASP9 protein]; Sodium Selenite inhibits the reaction [MIR125A mRNA mutant form results in increased expression of CASP9 protein] CTD PMID:26607349 NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007 		JBrowse link
G GPX4 glutathione peroxidase 4 increases activity EXP Sodium Selenite results in increased activity of GPX4 protein CTD PMID:10998458 NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,931 		JBrowse link
G KDSR 3-ketodihydrosphingosine reductase multiple interactions EXP Sodium Selenite inhibits the reaction [Cadmium Chloride promotes the reaction [MIR125A mRNA mutant form results in decreased expression of BCL2 protein]]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein]; Sodium Selenite inhibits the reaction [MIR125A mRNA mutant form results in decreased expression of BCL2 protein] CTD PMID:26607349 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases expression EXP Sodium Selenite results in increased expression of MAPK1 protein CTD PMID:17342738 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases expression EXP Sodium Selenite results in increased expression of MAPK3 protein CTD PMID:17342738 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567 		JBrowse link
G MIR125A microRNA mir-125a multiple interactions EXP Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAK1 protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAX protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP3 protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP9 protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride promotes the reaction [MIR125A mRNA mutant form results in decreased expression of BCL2 protein]]; Sodium Selenite inhibits the reaction [Cadmium results in decreased expression of MIR125A mRNA]; Sodium Selenite inhibits the reaction [MIR125A mRNA mutant form results in decreased expression of BCL2 protein]; Sodium Selenite inhibits the reaction [MIR125A mRNA mutant form results in increased expression of BAK1 protein]; Sodium Selenite inhibits the reaction [MIR125A mRNA mutant form results in increased expression of BAX protein]; Sodium Selenite inhibits the reaction [MIR125A mRNA mutant form results in increased expression of CASP3 protein]; Sodium Selenite inhibits the reaction [MIR125A mRNA mutant form results in increased expression of CASP9 protein] CTD PMID:26607349 NCBI chr 6:58,331,566...58,331,645
Ensembl chr 6:58,331,566...58,331,645 		JBrowse link
G POMC proopiomelanocortin multiple interactions EXP Ditiocarb promotes the reaction [Sodium Selenite inhibits the reaction [POMC protein results in increased secretion of Hydrocortisone]]; Sodium Selenite inhibits the reaction [POMC protein results in increased secretion of Hydrocortisone] CTD PMID:21466817 NCBI chr 3:113,661,712...113,668,558
Ensembl chr 3:113,661,004...113,670,418 		JBrowse link
ebselen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP4A ATPase H+/K+ transporting subunit alpha multiple interactions EXP ebselen results in decreased activity of [ATP4A protein binds to ATP4B protein] CTD PMID:7590103 NCBI chr 6:44,984,014...45,057,796
Ensembl chr 6:44,984,233...44,997,552 		JBrowse link
G ATP4B ATPase H+/K+ transporting subunit beta multiple interactions EXP ebselen results in decreased activity of [ATP4A protein binds to ATP4B protein] CTD PMID:7590103 NCBI chr11:78,780,013...78,785,143
Ensembl chr11:78,780,013...78,785,116 		JBrowse link
elemental selenium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP Selenium inhibits the reaction [Cadmium results in increased expression of BAX protein] CTD PMID:19135140 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140 		JBrowse link
G CASP3 caspase 3 multiple interactions EXP Selenium inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; Selenium inhibits the reaction [Cadmium results in increased activity of CASP3 protein] CTD PMID:17383151 PMID:19135140 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
G CASP9 caspase 9 multiple interactions EXP Selenium inhibits the reaction [Cadmium results in increased activity of CASP9 protein] CTD PMID:19135140 NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007 		JBrowse link
G GAPDH glyceraldehyde-3-phosphate dehydrogenase multiple interactions EXP Selenium inhibits the reaction [Paraquat results in decreased activity of GAPDH protein] CTD PMID:17055214 NCBI chr 5:64,129,678...64,135,194
Ensembl chr 5:64,129,679...64,133,991 		JBrowse link
G KDSR 3-ketodihydrosphingosine reductase multiple interactions EXP Selenium inhibits the reaction [Cadmium results in decreased expression of BCL2 protein] CTD PMID:19135140 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP Selenium inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:17383151 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions EXP Selenium inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK9 protein] CTD PMID:17383151 NCBI chr 2:78,338,466...78,399,108
Ensembl chr 2:78,338,376...78,399,100 		JBrowse link
G TXNRD1 thioredoxin reductase 1 increases expression
increases activity
multiple interactions		 EXP Selenium results in increased expression of TXNRD1 mRNA
Selenium results in increased activity of TXNRD1 protein
Selenium inhibits the reaction [Paraquat results in decreased activity of TXNRD1 protein]		 CTD PMID:16908641 PMID:17055214 NCBI chr 5:80,170,334...80,213,889
Ensembl chr 5:80,172,260...80,236,219 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5022
    chemical entity 5022
      atom 5013
        nonmetal atom 4973
          selenium atom 17
            selenium molecular entity 17
              Se-oxide + 0
              diselenide + 0
              elemental selenium + 8
              organoselenium compound + 2
              selenides + 0
              selenites + 11
              selenium coordination entity + 0
              selenium hydride + 0
              selenium oxoacid + 11
              selenium oxoanion + 0
              selenoglutathione 0
              selenomethionines + 0
              thioselenide + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 5022
    subatomic particle 5013
      composite particle 5013
        hadron 5013
          baryon 5013
            nucleon 5013
              atomic nucleus 5013
                atom 5013
                  main group element atom 4979
                    p-block element atom 4976
                      p-block molecular entity 4976
                        chalcogen molecular entity 4882
                          selenium molecular entity 17
                            Se-oxide + 0
                            diselenide + 0
                            elemental selenium + 8
                            organoselenium compound + 2
                            selenides + 0
                            selenites + 11
                            selenium coordination entity + 0
                            selenium hydride + 0
                            selenium oxoacid + 11
                            selenium oxoanion + 0
                            selenoglutathione 0
                            selenomethionines + 0
                            thioselenide + 0
paths to the root