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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:saturated fatty acid
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Accession:CHEBI:26607 term browser browse the term
Definition:Any fatty acid containing no carbon to carbon multiple bonds. Known to produce adverse biological effects when ingested to excess.
Synonyms:related_synonym: SFA;   SFAs;   saturated fatty acids
 xref: PMID:16492686;   PMID:19763019;   PMID:20237329


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(R)-lipoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Thioctic Acid inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein] CTD PMID:24512358 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183 		JBrowse link
4-phenylbutyric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF4 activating transcription factor 4 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Benzo(a)pyrene results in increased expression of ATF4 protein] CTD PMID:36754226 NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368 		JBrowse link
G ATF6 activating transcription factor 6 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Benzo(a)pyrene results in increased expression of ATF6 protein] CTD PMID:36754226 NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304 		JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions EXP 4-phenylbutyric acid promotes the reaction [Benzo(a)pyrene results in decreased expression of BCL2L1 protein] CTD PMID:36754226 NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,143...35,414,694 		JBrowse link
G CASP3 caspase 3 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [T-2 Toxin results in increased expression of CASP3 protein modified form] CTD PMID:34637808 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
G CLDN1 claudin 1 multiple interactions EXP 4-phenylbutyric acid promotes the reaction [Benzo(a)pyrene results in decreased expression of CLDN1 protein] CTD PMID:36754226 NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657 		JBrowse link
G CLDN3 claudin 3 multiple interactions EXP 4-phenylbutyric acid promotes the reaction [Benzo(a)pyrene results in decreased expression of CLDN3 protein] CTD PMID:36754226 NCBI chr 3:11,019,073...11,020,102
Ensembl chr 3:11,019,073...11,020,102 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Benzo(a)pyrene results in increased expression of DDIT3 protein] CTD PMID:36754226 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829 		JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of ERN1 protein] CTD PMID:36754226 NCBI chr12:14,881,913...14,963,290
Ensembl chr12:14,881,923...14,963,284 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Benzo(a)pyrene results in increased expression of HSPA5 protein] CTD PMID:36754226 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
G OCLN occludin multiple interactions EXP 4-phenylbutyric acid promotes the reaction [Benzo(a)pyrene results in decreased expression of OCLN protein] CTD PMID:36754226 NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033 		JBrowse link
G TJP1 tight junction protein 1 multiple interactions EXP 4-phenylbutyric acid promotes the reaction [Benzo(a)pyrene results in decreased expression of TJP1 protein] CTD PMID:36754226 NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836 		JBrowse link
6-oxoprostaglandin F1alpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 multiple interactions EXP [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid co-treated with EDN1 protein] results in decreased chemical synthesis of 6-Ketoprostaglandin F1 alpha CTD PMID:16325014 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348 		JBrowse link
all-trans-retinyl palmitate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDIA3 protein disulfide isomerase family A member 3 increases hydrolysis EXP PDIA3 protein results in increased hydrolysis of retinol palmitate CTD PMID:16798117 NCBI chr 1:127,786,174...127,814,096
Ensembl chr 1:127,785,772...127,814,196 		JBrowse link
alpha-(methylamino)isobutyric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin increases uptake
multiple interactions		 EXP INS protein results in increased uptake of 2-(methylamino)isobutyric acid
Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS protein results in increased uptake of 2-(methylamino)isobutyric acid]]; oxophenylarsine inhibits the reaction [INS protein results in increased uptake of 2-(methylamino)isobutyric acid]		 CTD PMID:1928324 NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841 		JBrowse link
bezafibrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOA1 apolipoprotein A1 increases expression
increases secretion		 EXP Bezafibrate results in increased expression of APOA1 mRNA
Bezafibrate results in increased secretion of APOA1 protein		 CTD PMID:16530456 NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,392...44,218,713 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP Bezafibrate inhibits the reaction [Cisplatin affects the localization of BAX protein] CTD PMID:16316343 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,147 		JBrowse link
G BCL2 BCL2 apoptosis regulator increases expression EXP Bezafibrate results in increased expression of BCL2 CTD PMID:16316343 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879 		JBrowse link
G CASP3 caspase 3 multiple interactions EXP Bezafibrate inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:16316343 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
G CYCS cytochrome c, somatic multiple interactions EXP Bezafibrate inhibits the reaction [Cisplatin affects the localization of CYCS protein] CTD PMID:16316343 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866 		JBrowse link
G LIPG lipase G, endothelial type decreases expression EXP Bezafibrate results in decreased expression of LIPG mRNA; Bezafibrate results in decreased expression of LIPG protein CTD PMID:15953354 NCBI chr 1:99,081,940...99,110,671
Ensembl chr 1:99,081,938...99,110,874 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions EXP Bezafibrate inhibits the reaction [[Cisplatin results in decreased activity of PPARA protein] which results in increased abundance of Fatty Acids, Nonesterified]; Bezafibrate inhibits the reaction [Cisplatin results in decreased activity of PPARA protein] CTD PMID:16316343 NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,741...3,364,239 		JBrowse link
G SCARB1 scavenger receptor class B member 1 affects localization
increases expression		 EXP Bezafibrate affects the localization of SCARB1 protein
Bezafibrate results in increased expression of SCARB1 mRNA		 CTD PMID:16530456 NCBI chr14:28,301,421...28,393,568
Ensembl chr14:28,301,294...28,393,568 		JBrowse link
bucladesine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 increases expression EXP Bucladesine results in increased expression of ATP1A1 protein CTD PMID:28438630 NCBI chr 4:104,353,506...104,384,321
Ensembl chr 4:104,353,506...104,384,680 		JBrowse link
clofibrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACO1 aconitase 1 increases expression EXP Clofibrate results in increased expression of ACO1 mRNA CTD PMID:17363680 NCBI chr10:33,937,833...34,001,895
Ensembl chr10:33,937,833...34,001,900 		JBrowse link
G ACOX1 acyl-CoA oxidase 1 increases expression EXP Clofibrate results in increased expression of ACOX1 mRNA CTD PMID:16896063 PMID:17437637 NCBI chr12:5,450,913...5,479,550
Ensembl chr12:5,439,361...5,479,546 		JBrowse link
G AGT angiotensinogen multiple interactions EXP Clofibrate inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein] CTD PMID:17105827 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833 		JBrowse link
G ALB albumin decreases expression EXP Clofibrate results in decreased expression of ALB mRNA CTD PMID:16896063 NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,721,696 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression EXP Clofibrate results in increased expression of BAX mRNA CTD PMID:17437637 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,147 		JBrowse link
G BCL2L1 BCL2 like 1 decreases expression EXP Clofibrate results in decreased expression of BCL2L1 mRNA CTD PMID:17437637 NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,143...35,414,694 		JBrowse link
G CAT catalase increases expression EXP Clofibrate results in increased expression of CAT mRNA CTD PMID:17437637 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452 		JBrowse link
G CPT1A carnitine palmitoyltransferase 1A increases expression EXP Clofibrate results in increased expression of CPT1A mRNA CTD PMID:16896063 PMID:17363680 NCBI chr 2:4,250,642...4,293,914
Ensembl chr 2:4,233,099...4,293,911 		JBrowse link
G CTSB cathepsin B increases expression EXP Clofibrate results in increased expression of CTSB mRNA CTD PMID:16896063 NCBI chr14:15,014,139...15,035,081
Ensembl chr14:15,011,711...15,033,877 		JBrowse link
G DIO2 iodothyronine deiodinase 2 decreases expression EXP Clofibrate results in decreased expression of DIO2 mRNA CTD PMID:16896063 NCBI chr 7:103,096,414...103,110,749
Ensembl chr 7:103,096,433...103,323,258 		JBrowse link
G EDN1 endothelin 1 decreases expression
multiple interactions		 EXP Clofibrate results in decreased expression of EDN1 protein
Clofibrate inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein]; Clofibrate inhibits the reaction [KNG1 protein modified form results in increased expression of EDN1 protein]; Clofibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EDN1 protein]; Nitric Oxide deficiency inhibits the reaction [Clofibrate results in decreased expression of EDN1 protein]		 CTD PMID:17105827 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348 		JBrowse link
G FABP1 fatty acid binding protein 1 increases expression EXP Clofibrate results in increased expression of FABP1 mRNA CTD PMID:17363680 NCBI chr 3:57,850,511...57,854,966
Ensembl chr 3:57,850,499...57,854,956 		JBrowse link
G GPX1 glutathione peroxidase 1 decreases expression EXP Clofibrate results in decreased expression of GPX1 mRNA CTD PMID:17437637 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433 		JBrowse link
G HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 increases expression EXP Clofibrate results in increased expression of HMGCS2 mRNA CTD PMID:17363680 NCBI chr 4:101,420,941...101,440,302
Ensembl chr 4:101,420,872...101,438,126 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP Clofibrate results in increased expression of JUN mRNA CTD PMID:17437637 NCBI chr 6:153,686,425...153,687,635
Ensembl chr 6:153,685,682...153,687,636 		JBrowse link
G KNG1 kininogen 1 multiple interactions EXP Clofibrate inhibits the reaction [KNG1 protein modified form results in increased expression of EDN1 protein] CTD PMID:17105827 NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,340...124,557,958 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor increases expression EXP Clofibrate results in increased expression of MYC mRNA CTD PMID:17437637 NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,122...12,461,078 		JBrowse link
G NOS3 nitric oxide synthase 3 increases expression
multiple interactions		 EXP Clofibrate results in increased expression of NOS3 protein
calphostin C inhibits the reaction [Clofibrate results in increased expression of NOS3 protein]		 CTD PMID:17105827 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha increases expression
multiple interactions		 EXP Clofibrate results in increased expression of PPARA; Clofibrate results in increased expression of PPARA protein
calphostin C inhibits the reaction [Clofibrate results in increased expression of PPARA protein]; calphostin C inhibits the reaction [Clofibrate results in increased expression of PPARA]; Tetradecanoylphorbol Acetate inhibits the reaction [Clofibrate results in increased expression of PPARA]		 CTD PMID:17105827 PMID:20568414 NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,741...3,364,239 		JBrowse link
G SCD stearoyl-CoA desaturase increases expression EXP Clofibrate results in increased expression of SCD mRNA CTD PMID:17363680 NCBI chr14:111,461,560...111,478,033
Ensembl chr14:111,461,569...111,478,020 		JBrowse link
G SLC5A5 solute carrier family 5 member 5 increases expression EXP Clofibrate results in increased expression of SLC5A5 mRNA CTD PMID:16896063 NCBI chr 2:59,869,157...59,885,086
Ensembl chr 2:59,869,155...59,885,266 		JBrowse link
G SOD1 superoxide dismutase 1 increases expression EXP Clofibrate results in increased expression of SOD1 mRNA CTD PMID:17437637 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729 		JBrowse link
G THRA thyroid hormone receptor alpha decreases expression EXP Clofibrate results in decreased expression of THRA mRNA CTD PMID:16896063 NCBI chr12:22,270,506...22,296,684
Ensembl chr12:22,270,062...22,296,618 		JBrowse link
G TNF tumor necrosis factor decreases expression EXP Clofibrate results in decreased expression of TNF mRNA CTD PMID:17437637 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415 		JBrowse link
G TPO thyroid peroxidase increases expression EXP Clofibrate results in increased expression of TPO mRNA CTD PMID:16896063 NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,409,208 		JBrowse link
G TSHR thyroid stimulating hormone receptor increases expression EXP Clofibrate results in increased expression of TSHR mRNA CTD PMID:16896063 NCBI chr 7:103,768,260...103,925,777
Ensembl chr 7:103,768,296...103,925,922 		JBrowse link
G TTR transthyretin decreases expression EXP Clofibrate results in decreased expression of TTR mRNA CTD PMID:16896063 NCBI chr 6:115,496,338...115,503,974
Ensembl chr 6:115,496,326...115,503,977 		JBrowse link
gabapentin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 affects binding EXP Gabapentin binds to CACNA2D1 protein CTD PMID:11687876 NCBI chr 9:97,781,057...98,265,925
Ensembl chr 9:97,781,090...98,266,969 		JBrowse link
ibuprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 decreases expression
multiple interactions		 EXP Ibuprofen results in decreased expression of NOS3 mRNA
11-deoxy-16-phenoxy-17,18,19,20-tetranorprostaglandin E1 inhibits the reaction [Ibuprofen results in decreased expression of NOS3 mRNA]; 11-deoxyprostaglandin E1 inhibits the reaction [Ibuprofen results in decreased expression of NOS3 mRNA]; 16,16-Dimethylprostaglandin E2 inhibits the reaction [Ibuprofen results in decreased expression of NOS3 mRNA]; sulprostone inhibits the reaction [Ibuprofen results in decreased expression of NOS3 mRNA]		 CTD PMID:10525081 PMID:10644584 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943 		JBrowse link
leptomycin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP2 bone morphogenetic protein 2 multiple interactions EXP leptomycin B inhibits the reaction [Warfarin results in increased expression of BMP2 mRNA] CTD PMID:34520801 NCBI chr17:15,750,487...15,762,982
Ensembl chr17:15,749,835...15,761,195 		JBrowse link
lipoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Thioctic Acid inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein] CTD PMID:24512358 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183 		JBrowse link
perfluorobutyric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALB albumin affects binding EXP perfluorobutyric acid binds to ALB protein CTD PMID:38518100 NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,721,696 		JBrowse link
perfluorohexanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALB albumin affects binding EXP perfluorohexanoic acid binds to ALB protein CTD PMID:38518100 NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,721,696 		JBrowse link
perfluorooctanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 decreases phosphorylation EXP perfluorooctanoic acid results in decreased phosphorylation of AKT1 protein CTD PMID:38145882
G ALB albumin affects binding EXP perfluorooctanoic acid binds to ALB protein CTD PMID:38518100 NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,721,696 		JBrowse link
phorbol 13-acetate 12-myristate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of CXCL8 protein CTD PMID:15912099 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861 		JBrowse link
G EDN1 endothelin 1 multiple interactions
increases expression		 EXP Clofibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EDN1 protein] CTD PMID:17105827 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation EXP Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein CTD PMID:11325585 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation EXP Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein CTD PMID:11325585 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 increases phosphorylation EXP Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK9 protein CTD PMID:11325585 NCBI chr 2:78,338,466...78,399,108
Ensembl chr 2:78,338,376...78,399,100 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha decreases expression
multiple interactions		 EXP Tetradecanoylphorbol Acetate results in decreased expression of PPARA; Tetradecanoylphorbol Acetate results in decreased expression of PPARA protein
calphostin C promotes the reaction [Tetradecanoylphorbol Acetate results in decreased expression of PPARA]; Tetradecanoylphorbol Acetate inhibits the reaction [Clofibrate results in increased expression of PPARA]		 CTD PMID:17105827 PMID:20568414 NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,741...3,364,239 		JBrowse link
G PRKCB protein kinase C beta decreases phosphorylation EXP Tetradecanoylphorbol Acetate results in decreased phosphorylation of PRKCB protein CTD PMID:15089098 NCBI chr 3:21,995,227...22,383,628
Ensembl chr 3:21,995,231...22,383,264 		JBrowse link
G PRKCD protein kinase C delta increases phosphorylation EXP Tetradecanoylphorbol Acetate results in increased phosphorylation of PRKCD protein CTD PMID:15089098 NCBI chr13:35,290,835...35,323,245
Ensembl chr13:35,290,610...35,323,356 		JBrowse link
G SELE selectin E increases expression EXP Tetradecanoylphorbol Acetate results in increased expression of SELE protein CTD PMID:16797888 NCBI chr 4:81,289,061...81,299,657 JBrowse link
G SELP selectin P increases expression EXP Tetradecanoylphorbol Acetate results in increased expression of SELP protein CTD PMID:16797888 NCBI chr 4:81,376,804...81,401,240
Ensembl chr 4:81,365,740...81,399,955 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 increases expression EXP Tetradecanoylphorbol Acetate results in increased expression of VCAM1 protein CTD PMID:16797888 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,920...117,511,222 		JBrowse link
prostaglandin D2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 multiple interactions
increases expression		 EXP BW A868C inhibits the reaction [Prostaglandin D2 results in increased expression of NOS3 mRNA]; Prostaglandin D2 inhibits the reaction [BW A868C results in decreased expression of NOS3 mRNA] CTD PMID:10644584 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943 		JBrowse link
prostaglandin E2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 multiple interactions EXP [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid co-treated with EDN1 protein] results in decreased chemical synthesis of Dinoprostone CTD PMID:16325014 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348 		JBrowse link
G OXT oxytocin/neurophysin I prepropeptide increases abundance
multiple interactions
increases secretion		 EXP OXT protein results in increased abundance of Dinoprostone
Progesterone inhibits the reaction [OXT protein results in increased secretion of Dinoprostone]		 CTD PMID:16997130 PMID:21370738 NCBI chr17:32,605,586...32,606,449
Ensembl chr17:32,605,586...32,606,546 		JBrowse link
G PLA2G1B phospholipase A2 group IB increases chemical synthesis EXP PLA2G1B protein results in increased chemical synthesis of Dinoprostone CTD PMID:10706128 NCBI chr14:40,314,520...40,322,315
Ensembl chr14:40,314,520...40,322,315 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [Polychlorinated Biphenyls results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; alpha-Linolenic Acid inhibits the reaction [[Polychlorinated Biphenyls results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Linoleic Acid promotes the reaction [[Polychlorinated Biphenyls results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Polychlorinated Biphenyls promotes the reaction [[Linoleic Acid results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Resveratrol inhibits the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone] CTD PMID:18155686 PMID:20825639 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884 		JBrowse link
prostaglandin F2alpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 increases activity
multiple interactions
increases expression		 EXP Dinoprost results in increased activity of CASP3 protein
[epostane co-treated with Dinoprost] results in increased activity of CASP3 protein; Dinoprost promotes the reaction [epostane results in increased expression of CASP3 mRNA]; epostane promotes the reaction [Dinoprost results in increased expression of CASP3 mRNA]		 CTD PMID:20739670 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 increases expression
multiple interactions		 EXP Dinoprost results in increased expression of CCL2 mRNA
[Dinoprost co-treated with epostane] results in increased expression of CCL2 mRNA		 CTD PMID:21505051 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026 		JBrowse link
G CCL4 C-C motif chemokine ligand 4 increases expression
multiple interactions		 EXP Dinoprost results in increased expression of CCL4 mRNA
[Dinoprost co-treated with epostane] results in increased expression of CCL4 mRNA		 CTD PMID:21505051 NCBI chr12:39,479,190...39,480,511
Ensembl chr12:39,478,882...39,481,082 		JBrowse link
G CCL8 chemokine (C-C motif) ligand 8 increases expression
multiple interactions		 EXP Dinoprost results in increased expression of CCL8 mRNA
[Dinoprost co-treated with epostane] results in increased expression of CCL8 mRNA		 CTD PMID:21505051 NCBI chr12:40,740,468...40,741,970
Ensembl chr12:40,740,023...40,742,022 		JBrowse link
G CCR1 C-C motif chemokine receptor 1 multiple interactions
increases expression		 EXP epostane promotes the reaction [Dinoprost results in increased expression of CCR1 mRNA] CTD PMID:21505051 NCBI chr13:29,227,218...29,233,862
Ensembl chr13:29,227,222...29,233,960 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 increases expression
multiple interactions		 EXP Dinoprost results in increased expression of CCR2 mRNA
epostane promotes the reaction [Dinoprost results in increased expression of CCR2 mRNA]		 CTD PMID:21505051 NCBI chr13:29,368,735...29,374,564
Ensembl chr13:29,369,122...29,376,343 		JBrowse link
G CCR5 C-C motif chemokine receptor 5 increases expression
multiple interactions		 EXP Dinoprost results in increased expression of CCR5 mRNA
epostane promotes the reaction [Dinoprost results in increased expression of CCR5 mRNA]		 CTD PMID:21505051 NCBI chr13:29,382,383...29,387,902
Ensembl chr13:29,383,303...29,387,895 		JBrowse link
G CXCL2 chemokine (C-X-C motif) ligand 2 multiple interactions
increases expression		 EXP [Dinoprost co-treated with epostane] results in increased expression of CXCL2 mRNA
Dinoprost results in increased expression of CXCL2 mRNA		 CTD PMID:21505051 NCBI chr 8:70,157,253...70,159,145
Ensembl chr 8:70,157,214...70,159,138 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression
multiple interactions		 EXP Dinoprost results in increased expression of CXCL8 mRNA
[Dinoprost co-treated with epostane] results in increased expression of CXCL8 mRNA		 CTD PMID:21505051 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861 		JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 multiple interactions
increases expression		 EXP epostane promotes the reaction [Dinoprost results in increased expression of CXCR2 mRNA] CTD PMID:21505051 NCBI chr15:120,219,657...120,230,203 JBrowse link
G CYP19A3 cytochrome P450 19A3 multiple interactions EXP [epostane co-treated with Dinoprost] results in increased expression of CYP19A1 mRNA CTD PMID:20739670 NCBI chr 1:120,476,890...120,556,103
Ensembl chr 1:120,367,667...120,695,899 		JBrowse link
G GHRL ghrelin and obestatin prepropeptide increases secretion
multiple interactions		 EXP GHRL protein results in increased secretion of Dinoprost
STAT1 protein inhibits the reaction [GHRL protein results in increased secretion of Dinoprost]		 CTD PMID:19528263 NCBI chr13:66,442,106...66,453,576
Ensembl chr13:66,445,992...66,452,917 		JBrowse link
G NFKBIA NFKB inhibitor alpha increases phosphorylation EXP Dinoprost results in increased phosphorylation of NFKBIA protein CTD PMID:21505051 NCBI chr 7:64,508,119...64,510,754
Ensembl chr 7:64,507,822...64,511,277 		JBrowse link
G OXT oxytocin/neurophysin I prepropeptide multiple interactions
increases abundance
increases secretion		 EXP Progesterone inhibits the reaction [OXT protein results in increased abundance of Dinoprost]; Progesterone inhibits the reaction [OXT protein results in increased secretion of Dinoprost] CTD PMID:16997130 PMID:21370738 NCBI chr17:32,605,586...32,606,449
Ensembl chr17:32,605,586...32,606,546 		JBrowse link
G PLA2G1B phospholipase A2 group IB multiple interactions EXP [epostane co-treated with Dinoprost] results in increased expression of PLA2G1B mRNA CTD PMID:20739670 NCBI chr14:40,314,520...40,322,315
Ensembl chr14:40,314,520...40,322,315 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [epostane co-treated with Dinoprost] results in increased expression of PTGS2 mRNA CTD PMID:20739670 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884 		JBrowse link
G STAT1 signal transducer and activator of transcription 1 multiple interactions
increases secretion		 EXP STAT1 protein inhibits the reaction [GHRL protein results in increased secretion of Dinoprost]
STAT1 protein results in increased secretion of Dinoprost		 CTD PMID:19528263 NCBI chr15:95,593,201...95,646,324
Ensembl chr15:95,593,211...95,646,260 		JBrowse link
prostaglandin J2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 multiple interactions EXP 9-deoxy-delta-9-prostaglandin D2 inhibits the reaction [[LHB protein co-treated with INS protein] results in increased expression of CYP17A1 mRNA] CTD PMID:11889176 NCBI chr14:113,805,616...113,820,445
Ensembl chr14:113,805,611...113,812,041 		JBrowse link
G INS insulin multiple interactions EXP 9-deoxy-delta-9-prostaglandin D2 inhibits the reaction [[LHB protein co-treated with INS protein] results in increased abundance of Androstenedione]; 9-deoxy-delta-9-prostaglandin D2 inhibits the reaction [[LHB protein co-treated with INS protein] results in increased abundance of Testosterone]; 9-deoxy-delta-9-prostaglandin D2 inhibits the reaction [[LHB protein co-treated with INS protein] results in increased expression of CYP17A1 mRNA] CTD PMID:11889176 NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841 		JBrowse link
G LHB luteinizing hormone subunit beta multiple interactions EXP 9-deoxy-delta-9-prostaglandin D2 inhibits the reaction [[LHB protein co-treated with INS protein] results in increased abundance of Androstenedione]; 9-deoxy-delta-9-prostaglandin D2 inhibits the reaction [[LHB protein co-treated with INS protein] results in increased abundance of Testosterone]; 9-deoxy-delta-9-prostaglandin D2 inhibits the reaction [[LHB protein co-treated with INS protein] results in increased expression of CYP17A1 mRNA] CTD PMID:11889176 NCBI chr 6:54,263,574...54,269,286
Ensembl chr 6:54,263,576...54,271,086 		JBrowse link
simvastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
decreases expression		 EXP Simvastatin promotes the reaction [Ezetimibe results in increased expression of HMGCR mRNA]
Simvastatin results in decreased expression of HMGCR mRNA		 CTD PMID:17130282 PMID:19343539 NCBI chr 2:84,380,245...84,401,117
Ensembl chr 2:84,380,224...84,402,957 		JBrowse link
G LDLR low density lipoprotein receptor multiple interactions
increases expression		 EXP Simvastatin promotes the reaction [Ezetimibe results in increased expression of LDLR mRNA]
Simvastatin results in increased expression of LDLR mRNA		 CTD PMID:17130282 NCBI chr 2:69,828,348...69,864,823
Ensembl chr 2:69,828,332...69,864,827 		JBrowse link
G NPC1L1 NPC1 like intracellular cholesterol transporter 1 multiple interactions EXP Simvastatin promotes the reaction [Ezetimibe results in increased expression of NPC1L1 mRNA] CTD PMID:17130282 NCBI chr18:50,726,854...50,757,676
Ensembl chr18:50,726,922...50,757,649 		JBrowse link
G NR4A3 nuclear receptor subfamily 4 group A member 3 decreases expression EXP Simvastatin results in decreased expression of NR4A3 mRNA CTD PMID:16005304 NCBI chr 1:241,569,867...241,611,735
Ensembl chr 1:241,570,010...241,611,727 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions EXP [Ezetimibe co-treated with Simvastatin] results in increased expression of SREBF1 mRNA CTD PMID:17130282 NCBI chr12:60,733,967...60,750,951
Ensembl chr12:60,733,907...60,751,267 		JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 multiple interactions EXP Simvastatin promotes the reaction [Ezetimibe results in increased expression of SREBF2 mRNA] CTD PMID:17130282 NCBI chr 5:6,719,484...6,784,724
Ensembl chr 5:6,719,490...6,784,671 		JBrowse link
thapsigargin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSP90B1 heat shock protein 90 beta family member 1 increases expression
multiple interactions
decreases expression
increases cleavage		 EXP Thapsigargin results in increased expression of HSP90B1 protein
PD 150606 inhibits the reaction [Thapsigargin results in increased cleavage of HSP90B1 protein]
Thapsigargin results in decreased expression of HSP90B1 protein		 CTD PMID:16759985 PMID:16920763 PMID:17416481 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Thapsigargin results in increased expression of HSPA5 protein CTD PMID:16759985 PMID:16920763 PMID:17416481 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5164
    chemical entity 5164
      atom 5155
        nonmetal atom 5120
          carbon atom 5041
            organic molecular entity 5041
              lipid 4531
                fatty acid 131
                  saturated fatty acid 82
                    (+)-pentacycloanammoxic acid + 0
                    11,12-methyleneoctadecanoic acid + 0
                    13-methylpentadecanoic acid 0
                    C20-C26 saturated fatty acid 0
                    C22-C26 saturated fatty acid 0
                    N-(saturated fatty acyl)ethanolamine + 0
                    branched-chain saturated fatty acid + 34
                    octadecanoic acid + 0
                    propionic acid + 10
                    prostanoic acid + 22
                    saturated fatty aldehyde + 0
                    saturated fatty ester C34H68O2 0
                    saturated fatty ester C36H72O2 0
                    saturated fatty ester C38H76O2 0
                    saturated fatty ester C40H80O2 0
                    saturated fatty ester C42H84O2 0
                    saturated fatty ester C43H86O2 0
                    saturated fatty ester C44H88O2 0
                    saturated fatty ester C46H92O2 0
                    straight-chain saturated fatty acid + 36
Path 2
Term Annotations click to browse term
  CHEBI ontology 5164
    subatomic particle 5155
      composite particle 5155
        hadron 5155
          baryon 5155
            nucleon 5155
              atomic nucleus 5155
                atom 5155
                  main group element atom 5127
                    p-block element atom 5124
                      carbon group element atom 5042
                        carbon atom 5041
                          organic molecular entity 5041
                            heteroorganic entity 4885
                              organochalcogen compound 4839
                                organooxygen compound 4803
                                  carbon oxoacid 393
                                    carboxylic acid 389
                                      monocarboxylic acid 231
                                        fatty acid 131
                                          saturated fatty acid 82
                                            (+)-pentacycloanammoxic acid + 0
                                            11,12-methyleneoctadecanoic acid + 0
                                            13-methylpentadecanoic acid 0
                                            C20-C26 saturated fatty acid 0
                                            C22-C26 saturated fatty acid 0
                                            N-(saturated fatty acyl)ethanolamine + 0
                                            branched-chain saturated fatty acid + 34
                                            octadecanoic acid + 0
                                            propionic acid + 10
                                            prostanoic acid + 22
                                            saturated fatty aldehyde + 0
                                            saturated fatty ester C34H68O2 0
                                            saturated fatty ester C36H72O2 0
                                            saturated fatty ester C38H76O2 0
                                            saturated fatty ester C40H80O2 0
                                            saturated fatty ester C42H84O2 0
                                            saturated fatty ester C43H86O2 0
                                            saturated fatty ester C44H88O2 0
                                            saturated fatty ester C46H92O2 0
                                            straight-chain saturated fatty acid + 36
paths to the root