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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-methoxyphenylethylamine
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Accession:CHEBI:266039 term browser browse the term
Definition:A primary amino compound consisting of ethylamine having a 4-methoxyphenyl substituent at the 2-position.
Synonyms:related_synonym: 2-(4-Methoxyphenyl)ethanamine;   2-(4-Methoxyphenyl)ethylamine;   2-(p-Methoxyphenyl)ethylamine;   4-Methoxy-2-phenethylamine;   4-Methoxy-beta-phenylethylamine;   4-Methoxybenzeneethanamine;   4-Methoxyphenethylamine;   Formula=C9H13NO;   Homoanisylamine;   InChI=1S/C9H13NO/c1-11-9-4-2-8(3-5-9)6-7-10/h2-5H,6-7,10H2,1H3;   InChIKey=LTPVSOCPYWDIFU-UHFFFAOYSA-N;   O-Methyltyramine;   SMILES=COc1ccc(CCN)cc1;   p-Methoxyphenethylamine;   p-Methoxyphenylethylamine
 xref: Beilstein:508967;   CAS:55-81-2;   Gmelin:2093996
 xref_mesh: MESH:C008510
 xref: PMID:21394332;   PMID:3377143;   Reaxys:508967


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4-methoxyphenylethylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Taar1 trace-amine-associated receptor 1 increases activity
multiple interactions		 ISO O-methyltyramine results in increased activity of TAAR1 protein
[O-methyltyramine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP		 CTD PMID:19725810 NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084 		JBrowse link
compound 48/80 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO p-Methoxy-N-methylphenethylamine results in increased secretion of CCL2 protein CTD PMID:34826398 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Gusb glucuronidase, beta increases secretion EXP p-Methoxy-N-methylphenethylamine results in increased secretion of GUSB protein CTD PMID:9545557 NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905 		JBrowse link
G Hexa hexosaminidase subunit alpha increases secretion
multiple interactions		 ISO p-Methoxy-N-methylphenethylamine results in increased secretion of HEXA protein
Apigenin inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased secretion of HEXA protein]		 CTD PMID:36350155 NCBI chr 8:59,936,526...59,961,654
Ensembl chr 8:59,936,660...59,962,013 		JBrowse link
G Hexb hexosaminidase subunit beta increases secretion ISO p-Methoxy-N-methylphenethylamine results in increased secretion of HEXB protein CTD PMID:34774977 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A increases activity EXP p-Methoxy-N-methylphenethylamine results in increased activity of HTR1A protein CTD PMID:16415902 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase affects response to substance ISO KIT protein affects the susceptibility to p-Methoxy-N-methylphenethylamine CTD PMID:32871113 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G Kng1 kininogen 1 decreases activity ISO p-Methoxy-N-methylphenethylamine results in decreased activity of KNG1 protein CTD PMID:1371395 NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase multiple interactions
increases activity		 EXP atractylon inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein]; damnacanthal inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein]; pyeongwee-san extract inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein] CTD PMID:27553716 NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO epigallocatechin gallate inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK1 protein] CTD PMID:29402411 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO epigallocatechin gallate inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK3 protein] CTD PMID:29402411 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mrgprx2 MAS related GPR family member X2 affects response to substance ISO MRGPRX2 protein affects the susceptibility to p-Methoxy-N-methylphenethylamine CTD PMID:32871113 NCBI chr 1:98,116,192...98,135,534 JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases activity ISO p-Methoxy-N-methylphenethylamine results in decreased activity of NR3C1 protein CTD PMID:7887964 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Tnf tumor necrosis factor increases secretion ISO p-Methoxy-N-methylphenethylamine results in increased secretion of TNF protein CTD PMID:34826398 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tpsb2 tryptase beta 2 increases secretion ISO p-Methoxy-N-methylphenethylamine results in increased secretion of TPSB2 protein CTD PMID:34826398 NCBI chr10:14,381,779...14,383,571
Ensembl chr10:14,382,013...14,383,569 		JBrowse link
N,O-dimethyltyramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO p-Methoxy-N-methylphenethylamine results in increased secretion of CCL2 protein CTD PMID:34826398 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Gusb glucuronidase, beta increases secretion EXP p-Methoxy-N-methylphenethylamine results in increased secretion of GUSB protein CTD PMID:9545557 NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905 		JBrowse link
G Hexa hexosaminidase subunit alpha multiple interactions
increases secretion		 ISO Apigenin inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased secretion of HEXA protein] CTD PMID:36350155 NCBI chr 8:59,936,526...59,961,654
Ensembl chr 8:59,936,660...59,962,013 		JBrowse link
G Hexb hexosaminidase subunit beta increases secretion ISO p-Methoxy-N-methylphenethylamine results in increased secretion of HEXB protein CTD PMID:34774977 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A increases activity EXP p-Methoxy-N-methylphenethylamine results in increased activity of HTR1A protein CTD PMID:16415902 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase affects response to substance ISO KIT protein affects the susceptibility to p-Methoxy-N-methylphenethylamine CTD PMID:32871113 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G Kng1 kininogen 1 decreases activity ISO p-Methoxy-N-methylphenethylamine results in decreased activity of KNG1 protein CTD PMID:1371395 NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase multiple interactions
increases activity		 EXP atractylon inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein]; damnacanthal inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein]; pyeongwee-san extract inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein] CTD PMID:27553716 NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK1 protein
epigallocatechin gallate inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK1 protein]		 CTD PMID:29402411 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO epigallocatechin gallate inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK3 protein] CTD PMID:29402411 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mrgprx2 MAS related GPR family member X2 affects response to substance ISO MRGPRX2 protein affects the susceptibility to p-Methoxy-N-methylphenethylamine CTD PMID:32871113 NCBI chr 1:98,116,192...98,135,534 JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases activity ISO p-Methoxy-N-methylphenethylamine results in decreased activity of NR3C1 protein CTD PMID:7887964 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Tnf tumor necrosis factor increases secretion ISO p-Methoxy-N-methylphenethylamine results in increased secretion of TNF protein CTD PMID:34826398 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tpsb2 tryptase beta 2 increases secretion ISO p-Methoxy-N-methylphenethylamine results in increased secretion of TPSB2 protein CTD PMID:34826398 NCBI chr10:14,381,779...14,383,571
Ensembl chr10:14,382,013...14,383,569 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      biological role 19805
        biochemical role 19515
          metabolite 19502
            alkaloid 7816
              2-phenylethylamine 25
                4-methoxyphenylethylamine 15
                  Cuscuta propenamide 1 0
                  N,O-dimethyltyramine + 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    main group molecular entity 19779
                      s-block molecular entity 19617
                        hydrogen molecular entity 19604
                          hydrides 19102
                            inorganic hydride 18114
                              pnictogen hydride 18103
                                nitrogen hydride 18010
                                  azane 17819
                                    ammonia 17818
                                      organic amino compound 17818
                                        amine 8280
                                          alkylamines 190
                                            aralkylamine 171
                                              2-phenylethylamine 25
                                                4-methoxyphenylethylamine 15
                                                  Cuscuta propenamide 1 0
                                                  N,O-dimethyltyramine + 14
paths to the root