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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:2659 term browser browse the term
Definition:A mixture comprising of theophylline and ethylenediamine in a 2:1 ratio.
Synonyms:exact_synonym: 1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione - ethane-1,2-diamine (2:1)
 related_synonym: 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione, compd with 1,2-ethanediamine (2:1);   Aminocardol;   Aminodur;   Aminodur dura-tabs;   Aminofillina;   Aminophyllin;   BY 108;   Cardiofilina;   Cardiomin;   Cardophylin;   Cardophyllin;   Carena;   Cariomin;   Diaphilline;   Diaphylline;   Diophllin;   Diophyllin;   Diuxanthine;   Dobo;   Ethophylline;   Etilen-Xantisan;   Eufilina;   Euphyllin;   Euphylline;   Euphyllinum;   Eurphyllin;   Euufilin;   Euufillin;   Formula=C7H8N4O2.C7H8N4O2.C2H8N2;   Genophyllin;   Grifomin;   InChI=1S/2C7H8N4O2.C2H8N2/c2*1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h2*3H,1-2H3,(H,8,9);1-4H2;   InChIKey=FQPFAHBPWDRTLU-UHFFFAOYSA-N;   Inophylline;   Lasodex;   Linampheta;   Lixaminol;   Metaphyllin;   Metaphylline;   Methophylline;   Minaphil;   Miofilin;   Neophyiline;   Neophylline;   Norofilina;   Peterphyllin;   Phylcardin;   Phyllindon;   Phyllocontin;   Rectalad aminophylline;   SMILES=C(CN)N.C12=C(N(C(=O)N(C1=O)C)C)N=CN2.C12=C(N(C(N(C1=O)C)=O)C)N=CN2;   Somophyllin;   Stenovasan;   Syntophyllin;   TAD;   TH/100;   Tefamin;   Theodrox;   Theolamine;   Theolone;   Theomin;   Theophyldine;   Theophyllamine;   Theophyllaminium;   Theophyllaminum;   Theophyllin aethylendiamin;   Theophylline ethylenediamine;   Thephyldine;   Truphylline;   Variaphylline;   Vasofilina;   aminofilina;   aminophyllinum;   theophyline ethylenediamine;   theophylline, compd with ethylenediamine (2:1)
 xref: CAS:317-34-0;   DrugBank:DB01223;   KEGG:D00227
 xref_mesh: MESH:D000628
 xref: PMID:10654755;   PMID:12615581;   PMID:14608279;   PMID:17391155;   PMID:18568240;   PMID:20206069;   PMID:21223510;   PMID:2636295;   PMID:30797981;   PMID:31122698;   Wikipedia:Aminophylline

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aminophylline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 increases expression ISO Aminophylline results in increased expression of ALDH18A1 mRNA CTD PMID:29901742 NCBI chr 1:259,641,673...259,674,521
Ensembl chr 1:259,641,676...259,674,425
Ensembl chr 1:259,641,676...259,674,425
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [Aminophylline co-treated with gemcitabine] results in decreased expression of BCL2 protein CTD PMID:15645133 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Cat catalase multiple interactions ISO [Aminophylline co-treated with Photosensitizing Agents] promotes the reaction [Benzo(a)pyrene results in increased expression of CAT protein] CTD PMID:30776357 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Gcg glucagon increases secretion EXP Aminophylline results in increased secretion of GCG protein CTD PMID:1248788 NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions ISO [Astemizole binds to and results in decreased activity of HRH1 protein] which affects the susceptibility to Aminophylline CTD PMID:16129921 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    chemical entity 19770
      chemical substance 12187
        mixture 11138
          aminophylline 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic molecule 19504
                              organic cyclic compound 19331
                                organic heterocyclic compound 18519
                                  organic heteropolycyclic compound 17978
                                    organic heterobicyclic compound 16778
                                      imidazopyrimidine 5583
                                        purines 5581
                                          aminopurine 4416
                                            2-aminopurines 4027
                                              guanine 3991
                                                xanthine 3901
                                                  methylxanthine 1146
                                                    dimethylxanthine 535
                                                      theophylline 529
                                                        aminophylline 5
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