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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:2659 term browser browse the term
Definition:A mixture comprising of theophylline and ethylenediamine in a 2:1 ratio.
Synonyms:exact_synonym: 1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione - ethane-1,2-diamine (2:1)
 related_synonym: 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione, compd with 1,2-ethanediamine (2:1);   Aminocardol;   Aminodur;   Aminodur dura-tabs;   Aminofillina;   Aminophyllin;   BY 108;   Cardiofilina;   Cardiomin;   Cardophylin;   Cardophyllin;   Carena;   Cariomin;   Diaphilline;   Diaphylline;   Diophllin;   Diophyllin;   Diuxanthine;   Dobo;   Ethophylline;   Etilen-Xantisan;   Eufilina;   Euphyllin;   Euphylline;   Euphyllinum;   Eurphyllin;   Euufilin;   Euufillin;   Formula=C7H8N4O2.C7H8N4O2.C2H8N2;   Genophyllin;   Grifomin;   InChI=1S/2C7H8N4O2.C2H8N2/c2*1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h2*3H,1-2H3,(H,8,9);1-4H2;   InChIKey=FQPFAHBPWDRTLU-UHFFFAOYSA-N;   Inophylline;   Lasodex;   Linampheta;   Lixaminol;   Metaphyllin;   Metaphylline;   Methophylline;   Minaphil;   Miofilin;   Neophyiline;   Neophylline;   Norofilina;   Peterphyllin;   Phylcardin;   Phyllindon;   Phyllocontin;   Rectalad aminophylline;   SMILES=C(CN)N.C12=C(N(C(=O)N(C1=O)C)C)N=CN2.C12=C(N(C(N(C1=O)C)=O)C)N=CN2;   Somophyllin;   Stenovasan;   Syntophyllin;   TAD;   TH/100;   Tefamin;   Theodrox;   Theolamine;   Theolone;   Theomin;   Theophyldine;   Theophyllamine;   Theophyllaminium;   Theophyllaminum;   Theophyllin aethylendiamin;   Theophylline ethylenediamine;   Thephyldine;   Truphylline;   Variaphylline;   Vasofilina;   aminofilina;   aminophyllinum;   theophyline ethylenediamine;   theophylline, compd with ethylenediamine (2:1)
 xref: CAS:317-34-0;   DrugBank:DB01223;   KEGG:D00227
 xref_mesh: MESH:D000628
 xref: PMID:10654755;   PMID:12615581;   PMID:14608279;   PMID:17391155;   PMID:18568240;   PMID:20206069;   PMID:21223510;   PMID:2636295;   PMID:30797981;   PMID:31122698;   Wikipedia:Aminophylline

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aminophylline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 increases expression ISO Aminophylline results in increased expression of ALDH18A1 mRNA CTD PMID:29901742 NCBI chr 1:239,375,657...239,407,967
Ensembl chr 1:239,375,669...239,407,890
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [Aminophylline co-treated with gemcitabine] results in decreased expression of BCL2 protein CTD PMID:15645133 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Cat catalase multiple interactions ISO [Aminophylline co-treated with Photosensitizing Agents] promotes the reaction [Benzo(a)pyrene results in increased expression of CAT protein] CTD PMID:30776357 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Gcg glucagon increases secretion EXP Aminophylline results in increased secretion of GCG protein CTD PMID:1248788 NCBI chr 3:47,113,914...47,122,929
Ensembl chr 3:47,113,914...47,122,929
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions ISO [Astemizole binds to and results in decreased activity of HRH1 protein] which affects the susceptibility to Aminophylline CTD PMID:16129921 NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    chemical entity 20058
      chemical substance 13263
        mixture 12462
          aminophylline 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19873
                          organic molecular entity 19873
                            organic molecule 19819
                              organic cyclic compound 19581
                                organic heterocyclic compound 18804
                                  organic heteropolycyclic compound 18274
                                    organic heterobicyclic compound 17165
                                      imidazopyrimidine 5624
                                        purines 5622
                                          aminopurine 4446
                                            2-aminopurines 4042
                                              guanine 4006
                                                xanthine 3916
                                                  methylxanthine 1150
                                                    dimethylxanthine 541
                                                      theophylline 529
                                                        aminophylline 5
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